Ifng

Summary

Gene Symbol: Ifng
Description: interferon gamma
Alias: IFN-g, Ifg, interferon gamma, IFN-gamma, gamma interferon
Species: mouse
Products:     Ifng

Top Publications

  1. Reid Yu S, Small C, Coombes B. CD3⁻NK1.1⁺ cells aid in the early induction of a Th1 response to an attaching and effacing enteric pathogen. Eur J Immunol. 2013;43:2638-49 pubmed publisher
    ..rodentium IgG in NK1.1-depleted mice. These data establish that CD3⁻NK1.1⁺ cells are critical for inducing an early Th1 response involved in clearance of a pathogen that is restricted to the gastrointestinal tract. ..
  2. Gomez J, Wapinski O, Yang Y, Bureau J, Gopinath S, Monack D, et al. The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus. Cell. 2013;152:743-54 pubmed publisher
    ..Thus, this lncRNA regulates epigenetic marking of IFN-γ-encoding chromatin, expression of IFN-γ, and susceptibility to a viral and a bacterial pathogen. ..
  3. Ouyang W, Liao W, Luo C, Yin N, Huse M, Kim M, et al. Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature. 2012;491:554-9 pubmed publisher
    ..analysis of Foxo1 binding sites reveals ~300 Foxo1-bound target genes, including the pro-inflammatory cytokine Ifng, that do not seem to be directly regulated by Foxp3...
  4. Mishra B, Rathinam V, Martens G, Martinot A, Kornfeld H, Fitzgerald K, et al. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β. Nat Immunol. 2013;14:52-60 pubmed publisher
    ..Our data indicate that the NO produced as a result of adaptive immunity is indispensable in modulating the destructive innate inflammatory responses elicited during persistent infections. ..
  5. Lu Y, Hong S, Li H, Park J, Hong B, Wang L, et al. Th9 cells promote antitumor immune responses in vivo. J Clin Invest. 2012;122:4160-71 pubmed publisher
    ..Our data suggest a distinct role for tumor-specific Th9 cells in provoking CD8+ CTL-mediated antitumor immunity and indicate that Th9 cell-based cancer immunotherapy may be a promising therapeutic approach. ..
  6. Hsieh M, Lai S, Chen J, Sung J, Lin Y, Wu Hsieh B, et al. Both CXCR3 and CXCL10/IFN-inducible protein 10 are required for resistance to primary infection by dengue virus. J Immunol. 2006;177:1855-63 pubmed
    ..Our results suggest that both CXCR3 and CXCL10/IP-10 contribute to resistance against primary dengue virus infection and that chemokines that are indistinguishable in in vitro assays differ in their activities in vivo. ..
  7. Hu Y, Hu X, Boumsell L, Ivashkiv L. IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways. J Immunol. 2008;180:8057-65 pubmed
    ..Crosstalk between Jak-STAT and Rac/Cdc42 GTPase-mediated signaling pathways provides a molecular mechanism by which cytokines can regulate cell migration. ..
  8. Sardinha L, Elias R, Mosca T, Bastos K, Marinho C, D Império Lima M, et al. Contribution of NK, NK T, gamma delta T, and alpha beta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi. Infect Immun. 2006;74:2031-42 pubmed
    ..The presence of numerous intrahepatic amastigotes in infected gamma interferon (IFN-gamma)-deficient mice corroborates the notion that the liver is protected by an efficient local immunity...
  9. Wysocka M, Kubin M, Vieira L, Ozmen L, Garotta G, Scott P, et al. Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice. Eur J Immunol. 1995;25:672-6 pubmed
    ..Thus, IL-12 is required for IFN-gamma production and lethality in an endotoxic shock model in mice. ..
  10. Quezada S, Simpson T, Peggs K, Merghoub T, Vider J, Fan X, et al. Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts. J Exp Med. 2010;207:637-50 pubmed publisher
    ....

Detail Information

Publications62

  1. Reid Yu S, Small C, Coombes B. CD3⁻NK1.1⁺ cells aid in the early induction of a Th1 response to an attaching and effacing enteric pathogen. Eur J Immunol. 2013;43:2638-49 pubmed publisher
    ..rodentium IgG in NK1.1-depleted mice. These data establish that CD3⁻NK1.1⁺ cells are critical for inducing an early Th1 response involved in clearance of a pathogen that is restricted to the gastrointestinal tract. ..
  2. Gomez J, Wapinski O, Yang Y, Bureau J, Gopinath S, Monack D, et al. The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus. Cell. 2013;152:743-54 pubmed publisher
    ..Thus, this lncRNA regulates epigenetic marking of IFN-γ-encoding chromatin, expression of IFN-γ, and susceptibility to a viral and a bacterial pathogen. ..
  3. Ouyang W, Liao W, Luo C, Yin N, Huse M, Kim M, et al. Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature. 2012;491:554-9 pubmed publisher
    ..analysis of Foxo1 binding sites reveals ~300 Foxo1-bound target genes, including the pro-inflammatory cytokine Ifng, that do not seem to be directly regulated by Foxp3...
  4. Mishra B, Rathinam V, Martens G, Martinot A, Kornfeld H, Fitzgerald K, et al. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β. Nat Immunol. 2013;14:52-60 pubmed publisher
    ..Our data indicate that the NO produced as a result of adaptive immunity is indispensable in modulating the destructive innate inflammatory responses elicited during persistent infections. ..
  5. Lu Y, Hong S, Li H, Park J, Hong B, Wang L, et al. Th9 cells promote antitumor immune responses in vivo. J Clin Invest. 2012;122:4160-71 pubmed publisher
    ..Our data suggest a distinct role for tumor-specific Th9 cells in provoking CD8+ CTL-mediated antitumor immunity and indicate that Th9 cell-based cancer immunotherapy may be a promising therapeutic approach. ..
  6. Hsieh M, Lai S, Chen J, Sung J, Lin Y, Wu Hsieh B, et al. Both CXCR3 and CXCL10/IFN-inducible protein 10 are required for resistance to primary infection by dengue virus. J Immunol. 2006;177:1855-63 pubmed
    ..Our results suggest that both CXCR3 and CXCL10/IP-10 contribute to resistance against primary dengue virus infection and that chemokines that are indistinguishable in in vitro assays differ in their activities in vivo. ..
  7. Hu Y, Hu X, Boumsell L, Ivashkiv L. IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways. J Immunol. 2008;180:8057-65 pubmed
    ..Crosstalk between Jak-STAT and Rac/Cdc42 GTPase-mediated signaling pathways provides a molecular mechanism by which cytokines can regulate cell migration. ..
  8. Sardinha L, Elias R, Mosca T, Bastos K, Marinho C, D Império Lima M, et al. Contribution of NK, NK T, gamma delta T, and alpha beta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi. Infect Immun. 2006;74:2031-42 pubmed
    ..The presence of numerous intrahepatic amastigotes in infected gamma interferon (IFN-gamma)-deficient mice corroborates the notion that the liver is protected by an efficient local immunity...
  9. Wysocka M, Kubin M, Vieira L, Ozmen L, Garotta G, Scott P, et al. Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice. Eur J Immunol. 1995;25:672-6 pubmed
    ..Thus, IL-12 is required for IFN-gamma production and lethality in an endotoxic shock model in mice. ..
  10. Quezada S, Simpson T, Peggs K, Merghoub T, Vider J, Fan X, et al. Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts. J Exp Med. 2010;207:637-50 pubmed publisher
    ....
  11. Naka T, Tsutsui H, Fujimoto M, Kawazoe Y, Kohzaki H, Morita Y, et al. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity. 2001;14:535-45 pubmed
    ....
  12. Rodriguez F, Harkins S, Slifka M, Whitton J. Immunodominance in virus-induced CD8(+) T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon. J Virol. 2002;76:4251-9 pubmed
    ..demonstrate that subdominant responses are actively suppressed by dominant CD8(+) T-cell responses and that gamma interferon (IFN-gamma) is required for this suppression...
  13. Soutto M, Zhang F, Enerson B, Tong Y, Boothby M, Aune T. A minimal IFN-gamma promoter confers Th1 selective expression. J Immunol. 2002;169:4205-12 pubmed
    ..Together, the results demonstrate that a minimal IFN-gamma promoter contains a T box expressed in T cells responsive unit and is sufficient to confer Th1 selective expression upon a reporter. ..
  14. Feng C, Zheng L, Jankovic D, Bafica A, Cannons J, Watford W, et al. The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol. 2008;9:1279-87 pubmed publisher
    ..Our studies identify a feedback mechanism in the T helper type 1 response that limits the detrimental effects of IFN-gamma on effector T lymphocyte survival while promoting the antimicrobial functions of IFN-gamma. ..
  15. Verri W, Cunha T, Parada C, Wei X, Ferreira S, Liew F, et al. IL-15 mediates immune inflammatory hypernociception by triggering a sequential release of IFN-gamma, endothelin, and prostaglandin. Proc Natl Acad Sci U S A. 2006;103:9721-5 pubmed
    ....
  16. Speyer C, Neff T, Warner R, Guo R, Sarma J, Riedemann N, et al. Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol. 2003;163:2319-28 pubmed
    ..In vitro stimulation of microvascular endothelial cells with LPS and IFN gamma revealed elevated production of CXC and CC chemokines in cells from iNOS(-/-) mice when compared to endothelial ..
  17. Zou J, Yamamoto N, Fujii T, Takenaka H, Kobayashi M, Herrmann S, et al. Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-gamma production by anti-tumor T cells. Int Immunol. 1995;7:1135-45 pubmed
    ....
  18. Jain R, Tartar D, Gregg R, Divekar R, Bell J, Lee H, et al. Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production. J Exp Med. 2008;205:207-18 pubmed publisher
    ..GAD2) represents a late-stage epitope, but GAD2-specific T cell receptor transgenic T cells producing interferon gamma (IFNgamma) protect against passive TID...
  19. Perona Wright G, Mohrs K, Mayer K, Mohrs M. Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo. J Immunol. 2010;184:615-23 pubmed publisher
    ..Together these data reveal a tightly controlled program of changing IL-4 responsiveness that characterizes the initiation, amplification, and restriction of a Th2 response in vivo. ..
  20. Banaiee N, Kincaid E, Buchwald U, Jacobs W, Ernst J. Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2. J Immunol. 2006;176:3019-27 pubmed
    ..These results establish that M. tuberculosis possesses multiple mechanisms of inhibiting responses to IFN-gamma. ..
  21. Doodes P, Cao Y, Hamel K, Wang Y, Rodeghero R, Mikecz K, et al. IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis. J Immunol. 2010;184:1552-9 pubmed publisher
    ..These results demonstrate that both IFN-gamma and IL-17 have the potential to induce PGIA, but it is the strength of the IFN-gamma response that regulates the contribution of each of these Th effector cytokines to disease. ..
  22. Campos R, Szczepanik M, Itakura A, Akahira Azuma M, Sidobre S, Kronenberg M, et al. Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity. J Exp Med. 2003;198:1785-96 pubmed
    ....
  23. Nansen A, Jensen T, Christensen J, Andreasen S, Ropke C, Marker O, et al. Compromised virus control and augmented perforin-mediated immunopathology in IFN-gamma-deficient mice infected with lymphocytic choriomeningitis virus. J Immunol. 1999;163:6114-22 pubmed
    ..Thus, the presence or absence of IFN-gamma determines whether CTLs will clear infection with this noncytopathogenic virus or induce severe immunopathology. ..
  24. Harty J, Bevan M. Specific immunity to Listeria monocytogenes in the absence of IFN gamma. Immunity. 1995;3:109-17 pubmed
    ..We demonstrate that resistance of IFN gamma gene knockout (GKO-/-) mice to the intracellular bacterium Listeria monocytogenes is severely impaired compared ..
  25. Hansen D, Bernard N, Nie C, Schofield L. NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malaria. J Immunol. 2007;178:5779-88 pubmed
    ....
  26. Kronenberg K, Brosch S, Butsch F, Tada Y, Shibagaki N, Udey M, et al. Vaccination with TAT-antigen fusion protein induces protective, CD8(+) T cell-mediated immunity against Leishmania major. J Invest Dermatol. 2010;130:2602-10 pubmed publisher
    ....
  27. Rodriguez M, Zoecklein L, Howe C, Pavelko K, Gamez J, Nakane S, et al. Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection. J Virol. 2003;77:12252-65 pubmed
    We evaluated the role of gamma interferon (IFN-gamma) in protecting neurons from virus-induced injury following central nervous system infection...
  28. Bouley D, Kanangat S, Wire W, Rouse B. Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice. J Immunol. 1995;155:3964-71 pubmed
    ....
  29. Berner V, Liu H, Zhou Q, Alderson K, Sun K, Weiss J, et al. IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nat Med. 2007;13:354-60 pubmed
    ..Thus, although immunotherapeutic regimens inducing strong IFN-gamma responses can lead to successful early antitumor efficacy, they may also impair the development of durable antitumor responses. ..
  30. Ilangumaran S, Ramanathan S, Ning T, La Rose J, Reinhart B, Poussier P, et al. Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes. Blood. 2003;102:4115-22 pubmed
    ..Because many different cell types express IL-15, our results strongly suggest that SOCS1 functions as an indispensable attenuator of IL-15 receptor signaling in developing CD8+ thymocytes. ..
  31. McLoughlin R, Witowski J, Robson R, Wilkinson T, Hurst S, Williams A, et al. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest. 2003;112:598-607 pubmed
    ..These data emphasize a pivotal role for IFN-gamma in regulating innate immunity through control of both the recruitment and clearance phases of PMN trafficking. ..
  32. Burdeinick Kerr R, Wind J, Griffin D. Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system. J Virol. 2007;81:5628-36 pubmed
    ....
  33. Wang Z, Hong J, Sun W, Xu G, Li N, Chen X, et al. Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. J Clin Invest. 2006;116:2434-41 pubmed
    ..These findings have important implications for the understanding of the complex role of IFN-gamma in both induction and self regulation of inflammatory processes. ..
  34. Stange J, Hepworth M, Rausch S, Zajic L, Kuhl A, Uyttenhove C, et al. IL-22 mediates host defense against an intestinal intracellular parasite in the absence of IFN-γ at the cost of Th17-driven immunopathology. J Immunol. 2012;188:2410-8 pubmed publisher
    ....
  35. Serreze D, Chapman H, Post C, Johnson E, Suarez Pinzon W, Rabinovitch A. Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation. J Immunol. 2001;166:1352-9 pubmed
    ....
  36. Aliberti J, Souto J, Marino A, Lannes Vieira J, Teixeira M, Farber J, et al. Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection. Am J Pathol. 2001;158:1433-40 pubmed
    ..cruzi infection and mediate resistance to infection. ..
  37. Awasthi A, Carrier Y, Peron J, Bettelli E, Kamanaka M, Flavell R, et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol. 2007;8:1380-9 pubmed
    ..Thus, IL-27 and transforming growth factor-beta promote the generation of IL-10-producing Tr1 cells. ..
  38. Rijneveld A, Lauw F, Schultz M, Florquin S, te Velde A, Speelman P, et al. The role of interferon-gamma in murine pneumococcal pneumonia. J Infect Dis. 2002;185:91-7 pubmed
    ..These data suggest that endogenous IFN-gamma, despite its protective role in defense against intracellular pathogens, does not serve a protective role during pneumococcal pneumonia. ..
  39. Lovett Racke A, Rocchini A, Choy J, Northrop S, Hussain R, Ratts R, et al. Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes. Immunity. 2004;21:719-31 pubmed
    ..Since T-bet regulates IFNgamma production in CD4(+) T cells, but to a lesser extent in most other IFNgamma-producing cells, T-bet may be a target for therapeutics for Th1-mediated diseases. ..
  40. Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, et al. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol. 2009;10:514-23 pubmed publisher
    ..Our results identify distinct molecular requirements and ports of lymphocyte entry into uninflamed versus inflamed CNS and suggest that the CCR6-CCL20 axis in the choroid plexus controls immune surveillance of the CNS. ..
  41. Wang S, Fan Y, Brunham R, Yang X. IFN-gamma knockout mice show Th2-associated delayed-type hypersensitivity and the inflammatory cells fail to localize and control chlamydial infection. Eur J Immunol. 1999;29:3782-92 pubmed
    ..Moreover, the data suggest that the IFN-gamma KO mouse is a useful model system for studying chlamydial pathogenesis. ..
  42. Tishon A, Lewicki H, Rall G, Von Herrath M, Oldstone M. An essential role for type 1 interferon-gamma in terminating persistent viral infection. Virology. 1995;212:244-50 pubmed
    ..In addition to the requirement for IFN-gamma, CD4+ T cells are essential for maintaining a CD8(+)-mediated cure of persistent viral infection. ..
  43. Alexander W, Starr R, Fenner J, Scott C, Handman E, Sprigg N, et al. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell. 1999;98:597-608 pubmed
    ..In this study, SOCS1-/- mice were shown to exhibit excessive responses typical of those induced by interferon gamma (IFNgamma), were hyperresponsive to viral infection, and yielded macrophages with an enhanced IFNgamma-..
  44. Satoh Takayama N, Vosshenrich C, Lesjean Pottier S, Sawa S, Lochner M, Rattis F, et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity. 2008;29:958-70 pubmed publisher
    ..RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces...
  45. Cheng M, Nguyen M, Fantuzzi G, Koh T. Endogenous interferon-gamma is required for efficient skeletal muscle regeneration. Am J Physiol Cell Physiol. 2008;294:C1183-91 pubmed publisher
    ..In summary, our results indicate that IFN-gamma promotes muscle healing, in part, by stimulating formation of new muscle fibers. ..
  46. Zhang H, Azimullah S, Zheng X, Wang X, Amir N, Mensah Brown E, et al. IFN-γ deficiency exacerbates experimental autoimmune neuritis in mice despite a mitigated systemic Th1 immune response. J Neuroimmunol. 2012;246:18-26 pubmed publisher
    ..In conclusion, IFN-γ deficiency exacerbates EAN via upregulating Th17 cells despite a mitigated systemic Th1 immune response. ..
  47. Hegazy A, Peine M, Helmstetter C, Panse I, Fröhlich A, Bergthaler A, et al. Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity. 2010;32:116-28 pubmed publisher
    ..Stable coexpression of GATA-3 and T-bet provides a molecular concept for the long-term coexistence of Th2 and Th1 cell lineage characteristics in single memory T cells. ..
  48. Yang Y, Ochando J, Bromberg J, Ding Y. Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals. Blood. 2007;110:2494-500 pubmed
    ..Together, we provide a novel mechanism for T-bet regulation, and suggest that IL-12/Stat4/T-bet play an important role in CD8 effector responses. ..
  49. Wozniak T, Saunders B, Ryan A, Britton W. Mycobacterium bovis BCG-specific Th17 cells confer partial protection against Mycobacterium tuberculosis infection in the absence of gamma interferon. Infect Immun. 2010;78:4187-94 pubmed publisher
    ..Both gamma interferon (IFN-γ)- and interleukin 17 (IL-17)-secreting CD4(+) T cells have been identified in subjects with latent TB ..
  50. Taylor A, Murray H. Intracellular antimicrobial activity in the absence of interferon-gamma: effect of interleukin-12 in experimental visceral leishmaniasis in interferon-gamma gene-disrupted mice. J Exp Med. 1997;185:1231-9 pubmed
    ..However, as judged by the effect of exogenous IL-12 this quiescent mechanism can readily be induced to rapidly yield enhanced intracellular antimicrobial activity. ..
  51. Lesinski G, Badgwell B, Zimmerer J, Crespin T, Hu Y, Abood G, et al. IL-12 pretreatments enhance IFN-alpha-induced Janus kinase-STAT signaling and potentiate the antitumor effects of IFN-alpha in a murine model of malignant melanoma. J Immunol. 2004;172:7368-76 pubmed
    ..However, this treatment regimen did not significantly prolong the survival of IFN-gamma-deficient (B6.129S7-Ifng(tm1Ts)) mice compared with mice treated with IFN-alpha alone...
  52. Dalton D, Pitts Meek S, Keshav S, Figari I, Bradley A, Stewart T. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science. 1993;259:1739-42 pubmed
    ..Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system. ..
  53. Molesworth Kenyon S, Yin R, Oakes J, Lausch R. IL-17 receptor signaling influences virus-induced corneal inflammation. J Leukoc Biol. 2008;83:401-8 pubmed
    ..Thus, IL-17 actively influences early virus-induced corneal inflammation. ..
  54. Kalis C, Gumenscheimer M, Freudenberg N, Tchaptchet S, Fejer G, Heit A, et al. Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes. J Immunol. 2005;174:4295-300 pubmed
    ..Because IFN-gamma is a key mediator of these effects, and enhanced IFN-gamma mRNA expression was absent in spleen and liver of P. acnes-primed TLR9(-/-) mice, we conclude that TLR9 is required for the induction of IFN-gamma by P. acnes. ..
  55. Simmons C, Goncalves N, Ghaem Maghami M, Bajaj Elliott M, Clare S, Neves B, et al. Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma. J Immunol. 2002;168:1804-12 pubmed
    ..These studies are among the first to examine mechanisms of host resistance to an attaching-effacing pathogen and show an important role for IL-12 and IFN-gamma in limiting bacterial infection of the colonic epithelium. ..
  56. Andoh A, Masuda A, Yamakawa M, Kumazawa Y, Kasajima T. Absence of interleukin-4 enhances germinal center reaction in secondary immune response. Immunol Lett. 2000;73:35-41 pubmed
    ..In conclusion, the absence of IL-4 enhanced GC reaction and specific antibody response of Th1-type. IL-4 may play an important role in inducing the appropriate magnitude of humoral immune response. ..
  57. Pai R, Pennini M, Tobian A, Canaday D, Boom W, Harding C. Prolonged toll-like receptor signaling by Mycobacterium tuberculosis and its 19-kilodalton lipoprotein inhibits gamma interferon-induced regulation of selected genes in macrophages. Infect Immun. 2004;72:6603-14 pubmed
    ..tuberculosis 19-kDa lipoprotein for >16 h inhibits gamma interferon (IFN-gamma)-induced major histocompatibility complex class II (MHC-II) expression by a mechanism involving ..
  58. Intlekofer A, Banerjee A, Takemoto N, Gordon S, Dejong C, Shin H, et al. Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science. 2008;321:408-11 pubmed publisher
    ..T-bet and Eomes, thus, ensure that CD8+ T cells adopt an appropriate course of intracellular rather than extracellular destruction. ..
  59. Amante F, Haque A, Stanley A, Rivera F, Randall L, Wilson Y, et al. Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria. J Immunol. 2010;185:3632-42 pubmed publisher
    ..These findings provide novel insights into immune-mediated mechanisms of ECM pathogenesis and highlight the potential of T cells to both prevent and promote infectious diseases. ..
  60. Zimmerman M, Yang D, Hu X, Liu F, Singh N, Browning D, et al. IFN-γ upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells. PLoS ONE. 2010;5:e14076 pubmed publisher
    ..Our findings delineate a new role of the IFN-γ signaling pathway in regulating T cell proliferation and apoptosis through upregulating survivin and ifi202 expression. ..
  61. Feng C, Collazo Custodio C, Eckhaus M, Hieny S, Belkaid Y, Elkins K, et al. Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. J Immunol. 2004;172:1163-8 pubmed
    ..These findings establish a role for LRG-47 in host control of mycobacteria and demonstrate that in the context of the IFN-gamma response to persistent infection, LRG-47 can have downstream regulatory effects on lymphocyte survival. ..
  62. Tu S, Quante M, Bhagat G, Takaishi S, Cui G, Yang X, et al. IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis. Cancer Res. 2011;71:4247-59 pubmed publisher
    ....