Ifngr1

Summary

Gene Symbol: Ifngr1
Description: interferon gamma receptor 1
Alias: CD119, IFN-gammaR, Ifgr, Ifngr, Nktar, interferon gamma receptor 1, IFN-gamma receptor 1, IFN-gamma-R-alpha, IFN-gamma-R1, INF-g receptor, interferon gamma receptor alpha-chain
Species: mouse

Top Publications

  1. ncbi IFN-gamma receptor-deficient mice are hypersensitive to the anti-CD3-induced cytokine release syndrome and thymocyte apoptosis. Protective role of endogenous nitric oxide
    P Matthys
    Laboratory of Immunobiology, Rega Institute, University of Leuven, Belgium
    J Immunol 155:3823-9. 1995
  2. ncbi Mice lacking the IFN-gamma receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile
    A J Coyle
    Department of Allergy and Asthma Research, Ciba Geigy Ltd, Basel, Switzerland
    J Immunol 156:2680-5. 1996
  3. ncbi Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice
    Sujan Shresta
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720, USA
    J Immunol 175:3946-54. 2005
  4. ncbi Functional role of type I and type II interferons in antiviral defense
    U Muller
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 264:1918-21. 1994
  5. pmc Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy
    A A Ashkar
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Exp Med 192:259-70. 2000
  6. pmc Tumor-specific Th17-polarized cells eradicate large established melanoma
    Pawel Muranski
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Mark O Hatfield Clinical Research Center, Bethesda, MD 20892, USA
    Blood 112:362-73. 2008
  7. pmc NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses
    Philippe Krebs
    Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 113:6593-602. 2009
  8. pmc Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide
    R Kamijo
    Department of Microbiology, Kaplan Cancer Center, New York University Medical Center, New York 10016
    J Exp Med 178:1435-40. 1993
  9. ncbi A role for the immunological synapse in lineage commitment of CD4 lymphocytes
    Roberto A Maldonado
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115 6017, USA
    Nature 431:527-32. 2004
  10. ncbi Developmentally regulated intestinal expression of IFN-gamma and its target genes and the age-specific response to enteric Salmonella infection
    Sue J Rhee
    Mucosal Immunology Laboratory, Pediatric Gastroenterology and Nutrition Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 175:1127-36. 2005

Research Grants

  1. Regulation of T cell immunity by indol 2,3 dioxygenase
    Andrew Mellor; Fiscal Year: 2006
  2. T CELL IMMUNOREGULATION BY TRYPTOPHAN DEPLETION
    Andrew Mellor; Fiscal Year: 2002
  3. CELLULAR PATHWAYS OF OCULAR IMMUNOREGULATION
    ROBERT CONE; Fiscal Year: 2003
  4. A Genetic Determinant of Resistance to HSV
    Edouard Cantin; Fiscal Year: 2006
  5. Interferon gamma in autoimmune thyroiditis & thyroid function
    Patrizio Caturegli; Fiscal Year: 2007
  6. Recruitment of memory CD8+ T cells to the lung airways
    JACOB KOHLMEIER; Fiscal Year: 2007
  7. IDO dependent T cell suppression
    Andrew Mellor; Fiscal Year: 2009
  8. T CELL CONTROL OF AIRWAY MUCUS PRODUCTION
    Lauren Cohn; Fiscal Year: 2009
  9. Ocular Regulation of Autoimmunity
    ROBERT CONE; Fiscal Year: 2009
  10. Thymic Influence on Ocular Immunoregulation
    Robert E Cone; Fiscal Year: 2010

Detail Information

Publications133 found, 100 shown here

  1. ncbi IFN-gamma receptor-deficient mice are hypersensitive to the anti-CD3-induced cytokine release syndrome and thymocyte apoptosis. Protective role of endogenous nitric oxide
    P Matthys
    Laboratory of Immunobiology, Rega Institute, University of Leuven, Belgium
    J Immunol 155:3823-9. 1995
    ..The data indicate that IFN-gamma R alpha o/o mice produce less NO and are therefore more sensitive than wild-type mice to the deleterious effect of anti-CD3 Ab...
  2. ncbi Mice lacking the IFN-gamma receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile
    A J Coyle
    Department of Allergy and Asthma Research, Ciba Geigy Ltd, Basel, Switzerland
    J Immunol 156:2680-5. 1996
    ....
  3. ncbi Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice
    Sujan Shresta
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720, USA
    J Immunol 175:3946-54. 2005
    ..Collectively, these data begin to define the nature of the STAT1-dependent vs the STAT1-independent pathway in vivo...
  4. ncbi Functional role of type I and type II interferons in antiviral defense
    U Muller
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 264:1918-21. 1994
    ..Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant...
  5. pmc Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy
    A A Ashkar
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Exp Med 192:259-70. 2000
    ....
  6. pmc Tumor-specific Th17-polarized cells eradicate large established melanoma
    Pawel Muranski
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Mark O Hatfield Clinical Research Center, Bethesda, MD 20892, USA
    Blood 112:362-73. 2008
    ..This principle should be considered in designing clinical trials involving adoptive transfer-based immunotherapy of human malignancies...
  7. pmc NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses
    Philippe Krebs
    Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 113:6593-602. 2009
    ..We think that the recognition and killing of target cells by NK cells represents an important pathway for the generation of robust CD8+ T and humoral responses that may be exploited for vaccine development...
  8. pmc Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide
    R Kamijo
    Department of Microbiology, Kaplan Cancer Center, New York University Medical Center, New York 10016
    J Exp Med 178:1435-40. 1993
    ....
  9. ncbi A role for the immunological synapse in lineage commitment of CD4 lymphocytes
    Roberto A Maldonado
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115 6017, USA
    Nature 431:527-32. 2004
    ..The interferon-gamma (IFNGR) and interleukin 4 (IL-4R) cytokine receptors, in particular, direct the earliest stages of T-helper commitment...
  10. ncbi Developmentally regulated intestinal expression of IFN-gamma and its target genes and the age-specific response to enteric Salmonella infection
    Sue J Rhee
    Mucosal Immunology Laboratory, Pediatric Gastroenterology and Nutrition Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 175:1127-36. 2005
    ..typhimurium infection resembled that of the wild-type pups. Our findings thus reveal a novel role for IFN-gamma in the developmental regulation of antimicrobial responses in the intestine...
  11. ncbi Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma(95-133)
    B E Szente
    Department of Microbiology and Cell Science, University of Florida, Gainesville 32611, USA
    J Immunol 155:5617-22. 1995
    ..Furthermore, the data support previous studies that demonstrated that intracellular IFN-gamma plays a role in cell activation...
  12. ncbi Development of antimalaria immunity in mice lacking IFN-gamma receptor
    M Tsuji
    Department of Medical and Molecular Parasitology, New York University School of Medicine, NY 10010, USA
    J Immunol 154:5338-44. 1995
    ..However, the nature of the anti-parasite mechanism(s) changes in the course of immunization, so that multiple immunizing doses elicit additional protective mechanisms, which are independent of IFN-gamma and its receptor...
  13. pmc Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors
    M F van den Broek
    Institute of Experimental Immunology, University of Zurich, Switzerland
    J Virol 69:4792-6. 1995
    ..Even though global antiviral immunoglobulin G (IgG) titers were within normal ranges, the IgG subclass distribution was heavily biased toward IgG1...
  14. pmc Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors
    L Fiette
    Unite des Virus Lents, UA 1157 Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France
    J Exp Med 181:2069-76. 1995
    ..They also lend support to the notion that the Ifg gene is involved in the resistance/susceptibility of inbred strains of mice to persistent infection by this picornavirus...
  15. pmc Interferon gamma signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain
    S A Marsters
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 92:5401-5. 1995
    ....
  16. pmc Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response
    K Swihart
    World Health Organization Immunology Research and Training Center, University of Lausanne, Epalinges, Switzerland
    J Exp Med 181:961-71. 1995
    ..These data show that even in the absence of IFN-gamma receptors, T helper cell (Th) 1-type responses still develop in genetically resistant mice with no evidence for the expansion of Th2 cells...
  17. ncbi IFN-gamma receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses
    V E Schijns
    Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, The Netherlands
    J Immunol 153:2029-37. 1994
    ..However, it profoundly impairs the generation of protective antiviral Ab...
  18. pmc Interferon gamma receptor deficient mice are resistant to endotoxic shock
    B D Car
    Institute of Toxicology of the Swiss Federal Institute of Technology, Zurich
    J Exp Med 179:1437-44. 1994
    ....
  19. pmc Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the interferon gamma receptor
    R Kamijo
    Department of Microbiology, New York University Medical Center, NY 10016
    Proc Natl Acad Sci U S A 90:6626-30. 1993
    ..The inability of other cytokines to substitute fully for IFN-gamma in macrophage activation helps to explain the earlier observed decreased resistance of IFN-gamma R0/0 mice to some infections...
  20. ncbi Immune response in mice that lack the interferon-gamma receptor
    S Huang
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 259:1742-5. 1993
    ..These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor...
  21. ncbi Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location
    J Hess
    Department of Immunology, University of Ulm, Germany
    J Immunol 156:3321-6. 1996
    ..typhimurium SL7207 Hlys and control strains did not differ in beta 2m-/- mutants. This finding argues against direct correlation of cytosolic location of S. typhimurium SL7207 Hlys with CD8+ T cell dependency of protection...
  22. ncbi Exacerbated viral hepatitis in IFN-gamma receptor-deficient mice is not suppressed by IL-12
    V E Schijns
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    J Immunol 157:815-21. 1996
    ..Furthermore, they emphasize the pivotal antiviral role of IFN-gamma in protection against acute coronavirus-induced hepatitis...
  23. ncbi Generation of nitric oxide and clearance of interferon-gamma after BCG infection are impaired in mice that lack the interferon-gamma receptor
    R Kamijo
    Department of Microbiology and Kaplan Cancer Center, New York University Medical Center, USA
    J Inflamm 46:23-31. 1995
    ....
  24. ncbi The IFN gamma receptor: a paradigm for cytokine receptor signaling
    E A Bach
    Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Immunol 15:563-91. 1997
    ..Together these insights have produced a model of IFN gamma signaling that is nearly complete and that serves as a paradigm for signaling by other members of the cytokine receptor superfamily...
  25. ncbi High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors
    B Manoury-Schwartz
    National Institute of Health and Medical Research INSERM, Unit 283, Rene Descartes University, Paris, France
    J Immunol 158:5501-6. 1997
    ....
  26. ncbi Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice
    K Vermeire
    Laboratory of Immunobiology, Rega Institute, University of Leuven, Belgium
    J Immunol 158:5507-13. 1997
    ..The data are in line with the concept of a pathogenic role of Th1-type cellular immunity in CIA in spite of a decreased Ab response to collagen type II...
  27. pmc Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection
    P Grob
    Institute of Virology, University of Zurich, CH 8057 Zurich, Switzerland
    J Virol 73:4748-54. 1999
    ..We present evidence that mice with an intact gamma IFN system but without mature B and T cells were able to prevent systemic dissemination of gE-TK-PRV...
  28. pmc Gamma interferon (IFN-gamma) receptor null-mutant mice are more susceptible to herpes simplex virus type 1 infection than IFN-gamma ligand null-mutant mice
    E Cantin
    Department of Neurology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA
    J Virol 73:5196-200. 1999
    Mouse strains with null mutations in the gamma interferon gene (Ifng) or the gamma interferon receptor gene (Ifngr) have been engineered...
  29. pmc Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytes
    C K Lee
    Department of Pathology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    J Exp Med 190:1451-64. 1999
    ....
  30. ncbi A novel transcription factor, T-bet, directs Th1 lineage commitment
    S J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cell 100:655-69. 2000
    ..Thus, T-bet initiates Th1 lineage development from naive Thp cells both by activating Th1 genetic programs and by repressing the opposing Th2 programs...
  31. ncbi Distinct requirements for IFNs and STAT1 in NK cell function
    C K Lee
    Department of Pathology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, NY 10016, USA
    J Immunol 165:3571-7. 2000
    ..These results demonstrate that both IFN-alpha and IFN-gamma are required to maintain NK cell function and define a STAT1-dependent but partially IFN-independent pathway required for NK-mediated antitumor activity...
  32. ncbi Lethal autoimmune myocarditis in interferon-gamma receptor-deficient mice: enhanced disease severity by impaired inducible nitric oxide synthase induction
    U Eriksson
    Medical Intensive Care Unit, University Hospital, Basel, Switzerland
    Circulation 103:18-21. 2001
    ..Interferon-gamma (IFN-gamma) is an essential cytokine in the regulation of inflammatory responses in autoimmune diseases. Little is known about its role in inflammatory heart disease...
  33. pmc IFN-gamma action in the media of the great elastic arteries, a novel immunoprivileged site
    A J Dal Canto
    Departments of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    J Clin Invest 107:R15-22. 2001
    ..These concepts have significant implications for understanding immune responses contributing to or controlling chronic inflammatory diseases of the great vessels...
  34. ncbi IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    V Shankaran
    Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 410:1107-11. 2001
    ..However, this process also leads to the immunoselection of tumour cells that are more capable of surviving in an immunocompetent host, which explains the apparent paradox of tumour formation in immunologically intact individuals...
  35. pmc Biologic consequences of Stat1-independent IFN signaling
    M P Gil
    Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:6680-5. 2001
    ..Thus, the IFN receptors engage alternative Stat1-independent signaling pathways that have important physiological consequences...
  36. pmc Murine gammaherpesvirus-68 infection causes multi-organ fibrosis and alters leukocyte trafficking in interferon-gamma receptor knockout mice
    B Ebrahimi
    Laboratory for Clinical and Molecular Virology, Department of Veterinary Pathology, University of Edinburgh, United Kingdom
    Am J Pathol 158:2117-25. 2001
    ..These changes suggest a role for dysregulated cytokines and chemokines in severe organ-specific fibrosis with implications for immune-mediated fibrotic disorders...
  37. pmc Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells
    R Ou
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Virol 75:8407-23. 2001
    ..We discuss the role of IFNs in influencing virus-specific T cells that determine the outcome of persistent infections...
  38. ncbi The role of interferon-gamma in murine pneumococcal pneumonia
    Anita W Rijneveld
    Department of Experimental Internal Medicine, Tropical Medicine, and AIDS, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 185:91-7. 2002
    ..These data suggest that endogenous IFN-gamma, despite its protective role in defense against intracellular pathogens, does not serve a protective role during pneumococcal pneumonia...
  39. ncbi The role of IFN in respiratory syncytial virus pathogenesis
    Joan E Durbin
    Children s Research Institute, Children s Hospital, Columbus, OH 43205, USA
    J Immunol 168:2944-52. 2002
    ..These findings suggest that STAT1 activation by both type I (alphabeta) and type II (gamma) IFNs plays an important role in establishing a protective, Th1 Ag-specific immune response to RSV infection...
  40. pmc Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity are less critical
    Sujan Shresta
    Division of Infectious Diseases, School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    J Virol 78:2701-10. 2004
    ....
  41. pmc Interplay between alpha/beta and gamma interferons with B, T, and natural killer cells in the defense against herpes simplex virus type 1
    Sabine Vollstedt
    Institute of Virology, University of Zurich, Zurich, Switzerland
    J Virol 78:3846-50. 2004
    ..These results suggest that distinct and essential immune elements are recruited in a time-dependent fashion to control acute and persistent HSV-1 infection...
  42. pmc Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments
    Ayuko Sato
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:16274-9. 2004
    ....
  43. pmc Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection
    Manuela Flórido
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    Infect Immun 73:3577-86. 2005
    ....
  44. ncbi A critical function for type I interferons in cancer immunoediting
    Gavin P Dunn
    Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Immunol 6:722-9. 2005
    ..Therefore, type I interferons are important components of the cancer immunoediting process and function in a way that does not completely overlap the functions of IFN-gamma...
  45. ncbi In vivo generation of pathogen-specific Th1 cells in the absence of the IFN-gamma receptor
    Jodie S Haring
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    J Immunol 175:3117-22. 2005
    ..Thus, both chains of the IFN-gammaR are dispensable for the generation of Th1 Ag-specific CD4 T cells after infection in vivo...
  46. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
    ..These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of pathogenic T(H)-17 effector cells that can exacerbate autoimmunity...
  47. ncbi Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    Marcel Batten
    Department of Molecular Biology, Genentech, South San Francisco, California 94080, USA
    Nat Immunol 7:929-36. 2006
    ..Finally, IL-27 suppressed IL-6-mediated T cell proliferation. These data provide a mechanistic explanation for the IL-27-mediated immune suppression noted in several in vivo models of inflammation...
  48. pmc Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system
    Rebeca Burdeinick-Kerr
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Virol 81:5628-36. 2007
    ....
  49. ncbi Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling
    Stephen J Turner
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 178:7616-22. 2007
    ..A virus infection of mice deficient for IFN-gamma (IFN-gamma(-/-)) or deficient for the IFN-gamma receptor 1 (IFNGR1(-/-)) was, when compared with the wild-type (WT) B6 controls, associated with increased Ag-specific CD8+ T cell ..
  50. ncbi Role of direct effects of IFN-gamma on T cells in the regulation of CD8 T cell homeostasis
    Kavita Tewari
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    J Immunol 179:2115-25. 2007
    ..These findings have clarified fundamental features of control of T cell homeostasis by IFN-gamma in the context of CD8 T cell memory and protective immunity...
  51. doi Interferon-gamma directly induces neurotoxicity through a neuron specific, calcium-permeable complex of IFN-gamma receptor and AMPA GluR1 receptor
    Tetsuya Mizuno
    Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo cho, Chikusa ku, Nagoya, 464 8601 Japan
    FASEB J 22:1797-806. 2008
    ..These findings provide novel mechanisms of neuronal excitotoxicity, which may occur in both inflammatory and neurodegenerative diseases in the CNS...
  52. pmc Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity
    Viviane Zorzanelli Rocha
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA, 02115, USA
    Circ Res 103:467-76. 2008
    ..These results indicate a role for T cells and IFNgamma, a prototypical T-helper 1 cytokine, in regulation of the inflammatory response that accompanies obesity...
  53. pmc Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse
    Roberto A Maldonado
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 206:877-92. 2009
    ..ligation, TCR stimuli induce the translocation of signal transducer and activator of transcription 1 (STAT1) to IFNGR1-rich regions of the membrane...
  54. doi Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12
    Edda G Schulz
    Theoretical Biophysics, Institute of Biology, Humboldt Universitat, Invalidenstrasse 42, 10115 Berlin, Germany
    Immunity 30:673-83. 2009
    ..Thus initial polarization and subsequent imprinting of Th1 cells are mediated by interlinked, sequentially acting positive feedback loops of TCR-interferon-gamma-Stat1-T-bet and interleukin-12-Stat4-T-bet signaling...
  55. pmc The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    Meghan A Koch
    Benaroya Research Institute, Seattle, Washington, USA
    Nat Immunol 10:595-602. 2009
    ....
  56. pmc Endotoxin augmented antigen-induced Th1 cell trafficking amplifies airway neutrophilic inflammation
    Zamaneh Mikhak
    Division of Rheumatology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Immunol 182:7946-56. 2009
    ..This reciprocal interaction between LPS and Ag-activated Th1 cells represents a collaborative connection between the innate and adaptive arms of the immune system...
  57. doi Glycogen synthase kinase-3beta facilitates IFN-gamma-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2
    Cheng Chieh Tsai
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    J Immunol 183:856-64. 2009
    ..All these results showed that activated GSK-3beta synergistically affected IFN-gamma-induced STAT1 activation by inhibiting SHP2...
  58. pmc T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis
    David C Gondek
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:1313-9. 2009
    ..Thus, we demonstrate that the secretion of IFN-gamma is necessary for protection against C. trachomatis and that in the absence of host cell IFN-gammaR expression, both Th1 and Th2 cells lead to increased burden of C. trachomatis...
  59. pmc Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis
    Ludovic Desvignes
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Immunity 31:974-85. 2009
    ..These results reveal a previously unsuspected role for IFN-gamma responsiveness in nonhematopoietic cells in regulation of immunity to M. tuberculosis and illustrate the role of IDO in the inhibition of Th17 cell responses...
  60. doi Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions
    Ahmed N Hegazy
    Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, 10117 Berlin, Germany
    Immunity 32:116-28. 2010
    ..Stable coexpression of GATA-3 and T-bet provides a molecular concept for the long-term coexistence of Th2 and Th1 cell lineage characteristics in single memory T cells...
  61. doi The type I interferon-alpha mediates a more severe neurological disease in the absence of the canonical signaling molecule interferon regulatory factor 9
    Markus J Hofer
    School of Molecular and Microbial Biosciences and Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia
    J Neurosci 30:1149-57. 2010
    ....
  62. pmc T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis
    Robert C Axtell
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA
    Nat Med 16:406-12. 2010
    ..Hence, IFN-beta is proinflammatory in T(H)17-induced EAE. Moreover, a high IL-17F concentration in the serum of people with RRMS is associated with nonresponsiveness to therapy with IFN-beta...
  63. doi Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria
    Nikolai N Belyaev
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London, UK
    Nat Immunol 11:477-85. 2010
    ..Thus, IFN-gamma is a key modulator of hematopoiesis and innate and adaptive immunity during acute malaria infection...
  64. pmc Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-γ signaling
    Katherine C MacNamara
    Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    J Immunol 186:1032-43. 2011
    ..We propose that, in addition to its many other known roles, IFN-γ acts to control infection by directly promoting the differentiation of myeloid cells that contribute to host defense...
  65. pmc Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes
    Veronika Lukacs-Kornek
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Immunol 12:1096-104. 2011
    ..Notably, in vivo expression of NOS2 by FRCs and LECs regulated the size of the activated T cell pool. Our study elucidates an as-yet-unrecognized role for the lymph node stromal niche in controlling T cell responses...
  66. pmc The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 37:660-73. 2012
    ..Our study revealed redundancy and synergy among several Th1 cell-inducing pathways in regulating the expression of T-bet and IFN-γ, and a critical role of T-bet in suppressing an endogenous Th2 cell-associated program...
  67. pmc Apoptotic regulation of T cells and absence of immune deficiency in virus-infected gamma interferon receptor knockout mice
    B L Lohman
    Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
    J Virol 72:7815-21. 1998
    ..This finding indicates that clonal exhaustion of CTL does not require IFN-gamma or Fas, even though both molecules influence AICD and the transient immune deficiency seen in the LCMV infection...
  68. ncbi Interferon-gamma contributes to the normalcy of murine pregnancy
    A A Ashkar
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Biol Reprod 61:493-502. 1999
    ..Furthermore, evidence is presented that IFN-gamma-producing cells exist in mesometrial regions of implantation sites that are neither NK nor T cells...
  69. ncbi Mice lacking IL-12 develop polarized Th1 cells during viral infection
    V E Schijns
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    J Immunol 160:3958-64. 1998
    ..Our data suggest that viruses may selectively induce IFN-gamma production and Th1-type immune reactions even in the absence of IL-12...
  70. ncbi CD4+ T cell--mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells
    Z Qin
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Immunity 12:677-86. 2000
    ..This shows that an effective anti-tumor response involves communication between CD4+ T cells and nonhematopoietic cells, most likely within the tumor stroma, and that tumor immunity must not entirely rely on direct tumor cell killing...
  71. doi Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells
    Pheh Ping Chang
    Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 189:701-10. 2012
    ....
  72. doi Collagen-induced arthritis as an animal model for rheumatoid arthritis: focus on interferon-γ
    Evelien Schurgers
    Laboratory of Immunobiology, Faculty of Medicine, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
    J Interferon Cytokine Res 31:917-26. 2011
    ....
  73. pmc Transgenic mice in the study of cytokine function
    J Taverne
    University College London Medical School, Department of Immunology, UK
    Int J Exp Pathol 74:525-46. 1993
  74. ncbi Deficiency of merosin in dystrophic dy mice and genetic linkage of laminin M chain gene to dy locus
    Y Sunada
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242
    J Biol Chem 269:13729-32. 1994
    ....
  75. ncbi Mouse soluble IFN gamma receptor as IFN gamma inhibitor. Distribution, antigenicity, and activity after injection in mice
    L Ozmen
    F Hoffmann La Roche Ltd, Pharmaceutical Research New Technologies, Basel, Switzerland
    J Immunol 150:2698-705. 1993
    ..Treatment with IFN-gamma or IFN-alpha A/D protected the mice from the lethal infection with encephalomyocarditis virus. Mice treated with MoIFN-gamma-R neutralized the protective effect of IFN-gamma...
  76. pmc Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells
    C H Tay
    Department of Pathology, University of Massachusetts Medical Center, Worcester 01655, USA
    J Virol 71:267-75. 1997
    ..These results may explain why the Cmv-lr locus, which maps closely to genes regulating NK cell cytotoxic function, confers an NK cell-dependent resistance to MCMV infection in the spleen but not in the liver...
  77. ncbi IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice
    C Haas
    Institute of Toxicology, University of Zurich, Switzerland
    J Immunol 158:5484-91. 1997
    ..Low levels of IFN-gamma-dependent IgG2a and IgG3 autoantibodies in MRL/lpr gammaR -/- mice might protect them from the pathogenic features of IgG3 cryoglobulins and complement-activating IgG2a and IgG3...
  78. pmc Interferon gamma regulates acute and latent murine cytomegalovirus infection and chronic disease of the great vessels
    R M Presti
    Center for Immunology, Departments of Pathology and Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 188:577-88. 1998
    ..This provides a new model for analysis of the interrelationships among herpesvirus latency, the immune system, and chronic disease of the great vessels...
  79. ncbi Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgenic mouse model by IFN-gamma-secreting T cells after DNA-based immunization
    M Mancini
    Unite de Recombinaison et Expression Genetique, Institut National de la Sante et de la Recherche Medicale, U163, Paris, France
    J Immunol 161:5564-70. 1998
    ..This effect was mediated by a cytokine-dependent mechanism common to both T cell subpopulations; this mechanism did not require cell lysis, but did involve the production of IFN-gamma by the activated T cells...
  80. ncbi IFN-alpha beta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection
    A G Rothfuchs
    Microbiology and Tumorbiology Center, Astrid Lindgren s Hospital, Karolinska Institutet, Stockholm, Sweden
    J Immunol 167:6453-61. 2001
    ..Our findings unravel an autocrine/paracrine macrophage activation pathway by showing an IFN-alphabeta-dependent IFN-gamma and iNOS induction in response to infection, which protects macrophages against intracellular bacterial growth...
  81. ncbi Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production
    Helen E Thomas
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Diabetes 51:311-6. 2002
    ..IL-1 + IFN-gamma-induced expression of iNOS was detected in non-beta-cells in both wild-type and RIP-DeltagammaR islets. These findings support the hypothesis that NO must be produced by beta-cells to induce damage...
  82. ncbi Mice lacking the IFN-gamma receptor or fyn develop severe experimental autoimmune uveoretinitis characterized by different immune responses
    Atsuki Fukushima
    Department of Ophthalmology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, 783 8505, Japan
    Immunogenetics 57:337-43. 2005
    ..The different cytokine production patterns by the GRKO and fyn KO mice indicate that the negative regulatory mechanism mediated by IFN-gammaR and fyn may differ...
  83. ncbi Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor
    David P Harris
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 174:6781-90. 2005
    ....
  84. pmc Th1 cytokines are essential for placental immunity to Listeria monocytogenes
    Ellen M Barber
    Department of Developmental and Molecular Biology and Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Infect Immun 73:6322-31. 2005
    ..These data show a requirement for Th1 cytokines during pregnancy for effective immunity and indicate that a bias away from Th1 cytokine synthesis is not a necessary prerequisite of pregnancy...
  85. ncbi Innate immune cells contribute to the IFN-gamma-dependent regulation of antigen-specific CD8+ T cell homeostasis
    Ozen Sercan
    German Cancer Research Center, Heidelberg, Germany
    J Immunol 176:735-9. 2006
    ..Thus, innate immune cells contribute to the IFN-gamma-dependent regulation of Ag-specific CD8+ T cell homeostasis...
  86. pmc Deleterious role of IFNgamma in a toxic model of central nervous system demyelination
    Paula Maña
    Neurosciences Research Unit, The Canberra Hospital, Australian National University Medical School, The Canberra Hospital, PO Box 11, Woden, 2601, Canberra, Australia
    Am J Pathol 168:1464-73. 2006
    ..In conclusion, this study suggests that IFNgamma regulates the development and resolution of the demyelinating syndrome and may be associated with toxic effects on both mature oligodendrocytes and oligodendrocyte precursor cells...
  87. pmc Infection with Syphacia obvelata (pinworm) induces protective Th2 immune responses and influences ovalbumin-induced allergic reactions
    Chesney Michels
    Health Science Faculty, Institute of Infectious Disease and Molecular Medicine IIDMM, University of Cape Town, Cape Town, South Africa
    Infect Immun 74:5926-32. 2006
    ..obvelata infection is able to influence nonrelated laboratory experiments. The latter outcome highlights the importance of maintaining mice for use as experimental models under pinworm-free conditions...
  88. ncbi SOCS-1 protects against Chlamydia pneumoniae-induced lethal inflammation but hampers effective bacterial clearance
    Tangbin Yang
    Department of Microbiology, Tumorbiology and Cell Biology, Karolinska Institute, Stockholm, Sweden
    J Immunol 180:4040-9. 2008
    ..pneumoniae infection induces a STAT1, IFN-alphabeta-dependent and IFN-gamma independent SOCS1 mRNA accumulation. Presence of SOCS1 controls the infection-induced lethal inflammatory disease but impairs the bacterial control...
  89. ncbi Th17 cells undergo Fas-mediated activation-induced cell death independent of IFN-gamma
    Yingyu Zhang
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    J Immunol 181:190-6. 2008
    ..Furthermore, Th17 cells derived from mice deficient in IFN-gamma receptor 1 (IFN-gammaR1-/-) underwent AICD similar to wild-type cells. Thus, AICD of Th17 cells occurs via the Fas pathway, but is independent of IFN-gamma...
  90. pmc Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination
    Christopher A Klebanoff
    Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD, USA
    Blood 114:1776-83. 2009
    ..These findings extend the phenomenon of a programmable effector response to memory CD8(+) T cells and have major implications for the design of current adoptive-cell transfer trials...
  91. pmc IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells
    Donggou He
    Department of Dermatology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 184:2281-8. 2010
    ..The study provides novel insights into the role of IL-17 in tumor development and has major implications for targeting IL-17 in treatment of tumors...
  92. pmc Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2
    Soila Sukupolvi-Petty
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Box 8051, St Louis, MO 63110, USA
    J Virol 84:9227-39. 2010
    ..Overall, these studies define the structural and functional complexity of antibodies against DENV-2 with protective potential...
  93. pmc Mice lacking alpha/beta and gamma interferon receptors are susceptible to junin virus infection
    Olga A Kolokoltsova
    Galveston National Laboratory, Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1019, USA
    J Virol 84:13063-7. 2010
    ..After peripheral inoculation with virulent JUNV, adult mice lacking alpha/beta and gamma interferon receptors developed disseminated infection and severe disease...
  94. pmc Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice
    Philippe Krebs
    Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 117:6582-8. 2011
    ..Our findings implicate MyD88 as the key initiator of myeloid and lymphoid proliferation in HLH, and suggest that blockade of this signaling molecule may reduce immunopathology in patients...
  95. ncbi Molecular genetic markers spanning mouse chromosome 10
    C A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 8:519-24. 1990
    ..include genes involved in oncogenesis (Gli, Myb, Tra-1), proviral integration (Emv-25), and immune responses (Ifg, Ifgr, Pfp)...
  96. ncbi Affinity purification, peptide analysis, and cDNA sequence of the mouse interferon gamma receptor
    F Cofano
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 265:4064-71. 1990
    ..Mouse IFN-gamma receptor cDNA when inserted in a mammalian shuttle vector and transfected into COS-7 monkey cells was able to direct the expression of specific binding activity for mouse IFN-gamma...
  97. pmc Cloning and expression of the cDNA for the murine interferon gamma receptor
    P W Gray
    Genentech, Inc, South San Francisco, CA 94080
    Proc Natl Acad Sci U S A 86:8497-501. 1989
    ..These results thus document the isolation and expression of a full-length murine IFN-gamma receptor cDNA and suggest that additional species-specific components may be necessary to form a biologically active IFN-gamma receptor...
  98. ncbi Characterization of the 5' flanking region and gene encoding the mouse interferon-gamma receptor
    P Raval
    Wilkinson Laboratory, University of Kansas Cancer Center, Kansas City 66160 7184, USA
    Gene 154:219-23. 1995
    ..Among the putative regulatory motifs identified by computer-assisted analysis are multiple SP1 and AP-2 sites, an NF1 and CCAAT box, as well as a potential cyclic AMP-responsive element (CRE)...
  99. ncbi IL-4 neutralization or TNF-alpha treatment ameliorate disease by an intracellular pathogen in IFN-gamma receptor-deficient mice
    G Szalay
    Department of Immunology, University of Ulm, Germany
    J Immunol 157:4746-50. 1996
    ..In cases where the primary gene defect cannot be restored, precise identification of secondary effects will promote rational immunotherapy based on neutralization or reconstitution of secondary immune deviations...
  100. ncbi IFN-gamma receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB x NZW)F1 mice
    C Haas
    Institute of Anatomy of the University of Zürich, Switzerland
    J Immunol 160:3713-8. 1998
    ..Thus, the absence of glomerulonephritis in BWgammaR(-/-) mice is likely due to a dramatic yet unexplained effect of the inactivation of IFN-gamma signaling on autoAb production...
  101. ncbi Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice
    M E Rottenberg
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
    J Immunol 162:2829-36. 1999
    ..pneumoniae. The higher sensitivity of IFN-gammaR-/- mice to C. pneumoniae compared with that of SCID or recombination-activating gene-1-/- mice suggested a relevant protective role of IFN-gamma-dependent innate mechanisms of protection...

Research Grants12

  1. Regulation of T cell immunity by indol 2,3 dioxygenase
    Andrew Mellor; Fiscal Year: 2006
    ....
  2. T CELL IMMUNOREGULATION BY TRYPTOPHAN DEPLETION
    Andrew Mellor; Fiscal Year: 2002
    ....
  3. CELLULAR PATHWAYS OF OCULAR IMMUNOREGULATION
    ROBERT CONE; Fiscal Year: 2003
    ..Understanding of this axis could impact on the management o f inflammatory eye disease, organ transplants (e.g. cornea), ocular tumors and autoimmune disease. ..
  4. A Genetic Determinant of Resistance to HSV
    Edouard Cantin; Fiscal Year: 2006
    ..abstract_text> ..
  5. Interferon gamma in autoimmune thyroiditis & thyroid function
    Patrizio Caturegli; Fiscal Year: 2007
    ..We also hypothesize that augmented TSH signaling is required to induce the adipocyte-rich phenotype, and cross thyr-IFNg transgenics to TSH receptor knockout mice. ..
  6. Recruitment of memory CD8+ T cells to the lung airways
    JACOB KOHLMEIER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. IDO dependent T cell suppression
    Andrew Mellor; Fiscal Year: 2009
    ..Studies in Aim 2 examine how minor subsets of IDO-competent DCs promote dominant T cell suppression and studies in Aim 3 examine the relationship between IDO expression and Treg development and function. ..
  8. T CELL CONTROL OF AIRWAY MUCUS PRODUCTION
    Lauren Cohn; Fiscal Year: 2009
    ..AIM II. Determine the mechanism of IFN-g inhibition of eosinophilia and its relationship to the reciprocal induction of neutrophilia. AIM III. Determine how IFN-g regulates the number of Th2 cells in the respiratory tract. ..
  9. Ocular Regulation of Autoimmunity
    ROBERT CONE; Fiscal Year: 2009
    ..The results of this study could aid our understanding of the systemic basis for the ocular regulation of autoimmunity and develop procedures for the modulation of active autoimmune disease. ..
  10. Thymic Influence on Ocular Immunoregulation
    Robert E Cone; Fiscal Year: 2010
    ....
  11. T cell regulation by IDO-competent plasmacytoid dendritic cells
    ANDREW LEE MELLOR; Fiscal Year: 2010
    ..This observation provides a rationale for treating mice with donor allograft and self-antigens to induce tolerance that will protect skin grafts and pancreatic islet cells from T cell mediated destruction. 1 ..
  12. Mechanisms of IVIG Protection in Viral Encephalitis
    EDOUARD M CANTIN; Fiscal Year: 2010
    ..Results from these studies will be important for making the case for IVIG as a treatment for neuroinflammatory diseases including encephalitis caused by HSV and other viruses like West Nile virus that are potential bioterrorism agents. ..