Ikbke

Summary

Gene Symbol: Ikbke
Description: inhibitor of kappaB kinase epsilon
Alias: AW558201, IKK-i, IKKepsilon, Ikki, inhibitor of nuclear factor kappa-B kinase subunit epsilon, I-kappa-B kinase epsilon, IKK-E, IKK-epsilon, inducible I kappa-B kinase, inducible IKappaB kinase, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Species: mouse

Top Publications

  1. ncbi Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity
    Benjamin R tenOever
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Science 315:1274-8. 2007
  2. pmc Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD
    Minying Zhang
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 283:18621-6. 2008
  3. ncbi IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli
    Vladimir V Kravchenko
    Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 278:26612-9. 2003
  4. doi The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia
    Christine V Möser
    Pharmazentrum Frankfurt Das Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, 60590 Frankfurt am Main, Germany
    J Immunol 187:2617-25. 2011
  5. pmc IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation
    Xiaoduo Xie
    Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:6474-9. 2011
  6. doi Beneficial effects of IKKε-deficiency on body weight and insulin sensitivity are lost in high fat diet-induced obesity in mice
    Ludger Scheja
    Department of Biochemistry and Molecular Biology II, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Biochem Biophys Res Commun 407:288-94. 2011
  7. pmc The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation
    Katarzyna Bulek
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Nat Immunol 12:844-52. 2011
  8. pmc IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation
    Jian Ping Guo
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 286:37389-98. 2011
  9. doi Novel splice variants of human IKKε negatively regulate IKKε-induced IRF3 and NF-kB activation
    Anja Koop
    Institute of Immunology, Christian Albrechts University Kiel, Kiel, Germany
    Eur J Immunol 41:224-34. 2011
  10. pmc The protein kinase IKKepsilon regulates energy balance in obese mice
    Shian Huey Chiang
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 138:961-75. 2009

Scientific Experts

  • Ken J Ishii
  • Sarah L Doyle
  • Susan E Sweeney
  • Ludger Scheja
  • Kouhei Yamashita
  • Ahmet Civas
  • Changchun Cao
  • Shizuo Akira
  • Jian Ping Guo
  • Benjamin R tenOever
  • Serkan Ismail Göktuna
  • Tieu Lan Chau
  • Jiayi Yu
  • Xin Chen
  • Wen Chen
  • Yongchao Qi
  • Yifan Zhu
  • Alexander Hoffmann
  • Mikyoung Chang
  • Eddy T H Goh
  • Shao Cong Sun
  • Jonathan Mowers
  • Muhammet F Gulen
  • Katarzyna Bulek
  • Shian Huey Chiang
  • Sze Ling Ng
  • Osamu Takeuchi
  • Mihir Rajurkar
  • Junjie Zhang
  • Jinjin Xu
  • Alain Chariot
  • Kateryna Shostak
  • Pierre Close
  • Hong Quan Duong
  • Meghana N Patel
  • Pinghui Feng
  • Hao Feng
  • Yu Zhang
  • Bart Everts
  • Yohei Sanada
  • Laís Weissmann
  • Bryce N Alves
  • Ricardo Rajsbaum
  • Yuichiro Nakatsu
  • Chikako Ono
  • Xin Wan
  • Liangpeng Li
  • Yichuan Xiao
  • Jae Hoon Chang
  • Xiaodi Wang
  • Daniela Bruni
  • Jia Dai
  • Donald T Gracias
  • Yi Wang
  • Sonja Schmid
  • Matthias Farlik
  • Fangfang Qu
  • Jin Q Cheng
  • Jin Jin
  • Peter C F Cheung
  • Xiaoxia Li
  • Philip Cohen
  • Hilary Smith
  • Urmila Maitra
  • Olivia Perwitasari
  • Xiaoduo Xie
  • Alan R Saltiel
  • Anja Koop
  • Christine V Möser
  • Adolfo Garcia-Sastre
  • Tomohiro Watanabe
  • Rita Moreno
  • Taro Kawai
  • Masahiro Yamamoto
  • Tom Maniatis
  • Olga V Savinova
  • Minying Zhang
  • Beichu Guo
  • Fumiyo Ikeda
  • Kosuke Matsui
  • Annie Bibeau-Poirier
  • Shintaro Sato
  • Hiroaki Hemmi
  • Kyvan Dang
  • Junhao Mao
  • Maite G Fernández-Barrena
  • Xiangfan Liu
  • Brian C Lewis
  • Martin E Fernandez-Zapico
  • Robb E Moses

Detail Information

Publications58

  1. ncbi Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity
    Benjamin R tenOever
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Science 315:1274-8. 2007
    b>IKKepsilon is an IKK (inhibitor of nuclear factor kappaBkinase)-related kinase implicated in virus induction of interferon-beta (IFNbeta)...
  2. pmc Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD
    Minying Zhang
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 283:18621-6. 2008
    The IkappaB kinase (IKK)-related kinases, IKKepsilon and TBK1, participate in the induction of type I interferons (IFNs) during viral infections...
  3. ncbi IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli
    Vladimir V Kravchenko
    Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 278:26612-9. 2003
    We report that the product of the inducible gene encoding the kinase known as IKKi/IKKepsilon (IKKi) is required for expression of a group of genes up-regulated by pro-inflammatory stimuli such as bacterial endotoxin (lipopolysaccharide (..
  4. doi The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia
    Christine V Möser
    Pharmazentrum Frankfurt Das Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, 60590 Frankfurt am Main, Germany
    J Immunol 187:2617-25. 2011
    ..Therefore, we concluded that IKKε modulates inflammatory nociceptive sensitivity by activation of NF-κB-dependent gene transcription and may be useful as a therapeutic target in the treatment of inflammatory pain...
  5. pmc IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation
    Xiaoduo Xie
    Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:6474-9. 2011
    ..Our observations suggest a physiological function of IKKε/TBK1 in AKT regulation and a possible mechanism of IKKε/TBK1 in oncogenesis by activating AKT...
  6. doi Beneficial effects of IKKε-deficiency on body weight and insulin sensitivity are lost in high fat diet-induced obesity in mice
    Ludger Scheja
    Department of Biochemistry and Molecular Biology II, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Biochem Biophys Res Commun 407:288-94. 2011
    ....
  7. pmc The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation
    Katarzyna Bulek
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Nat Immunol 12:844-52. 2011
    ..we report that Act1, the key adaptor for the IL-17 receptor (IL-7R), formed a complex with the inducible kinase IKKi after stimulation with IL-17...
  8. pmc IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation
    Jian Ping Guo
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 286:37389-98. 2011
    ..Activation of Akt by mitogenic factor depends on phosphatidylinositol 3-kinase (PI3K). Here, we report that IKBKE (also known as IKKε and IKKi) activates Akt through a PI3K-independent pathway...
  9. doi Novel splice variants of human IKKε negatively regulate IKKε-induced IRF3 and NF-kB activation
    Anja Koop
    Institute of Immunology, Christian Albrechts University Kiel, Kiel, Germany
    Eur J Immunol 41:224-34. 2011
    ..Taken together, our data suggest alternative splicing as a novel regulatory mechanism suitable to shift the balance between different functions of IKKε...
  10. pmc The protein kinase IKKepsilon regulates energy balance in obese mice
    Shian Huey Chiang
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 138:961-75. 2009
    ..increase NF-kappaB activation in mice, which leads to a sustained elevation in level of IkappaB kinase epsilon (IKKepsilon) in liver, adipocytes, and adipose tissue macrophages...
  11. pmc Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes
    Fumiyo Ikeda
    Institute of Biochemistry II, Goethe University Medical School, Frankfurt, Germany
    EMBO J 26:3451-62. 2007
    ..We propose that the ULD is a regulatory component of the TBK1/IKK-i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways...
  12. pmc The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling
    Jin Jin
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 13:1101-9. 2012
    ..Our findings establish TBK1 as a pivotal negative regulator of the noncanonical NF-κB pathway and identify a unique mechanism that controls IgA production...
  13. ncbi Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK
    Beichu Guo
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095, USA
    J Biol Chem 282:11817-26. 2007
    ..adaptor inducing interferon-beta), and TRAF3 and downstream mediators TANK-binding kinase 1, inducible IkappaB kinase, and interferon regulatory factor 3...
  14. ncbi IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases
    T Shimada
    Department of Biochemistry, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Int Immunol 11:1357-62. 1999
    ..These results suggest that IKK-i is an inducible IkappaB kinase which may play a special role in the immune response.
  15. ncbi Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon complex in fibroblast-like synoviocytes
    Susan E Sweeney
    Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    J Immunol 174:6424-30. 2005
    ..The IkappaB kinase (IKK)-related kinase, IKKepsilon/IKKi, which plays a pivotal role in regulating antiviral gene transcription, is constitutively expressed by ..
  16. pmc The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection
    Hiroaki Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Exp Med 199:1641-50. 2004
    ..Recently, two IkappaB kinase (IKK)-related kinases, inducible IkappaB kinase (IKK-i) and TANK-binding kinase 1 (TBK1), were suggested to act as IRF-3 kinases and be involved in IFN-..
  17. pmc Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells
    Chikako Ono
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Virol 88:2157-67. 2014
    ....
  18. pmc Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1
    Jonathan Mowers
    Life Sciences Institute, University of Michigan, Ann Arbor, United States
    elife 2:e01119. 2013
    ..These studies suggest that by reducing production of cAMP in adipocytes, IKKε and TBK1 may contribute to the repression of energy expenditure during obesity. DOI: http://dx.doi.org/10.7554/eLife.01119.001. ..
  19. pmc TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation
    Bart Everts
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 15:323-32. 2014
    ..In summary, we identified the rapid induction of glycolysis as an integral component of TLR signaling that is essential for the anabolic demands of the activation and function of DCs. ..
  20. pmc Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15
    Sarah L Doyle
    Immunology Research Centre, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 288:25066-75. 2013
    ..Our study identifies NFκB2 as a target for IKKε in antiviral immunity and describes, for the first time, a role for NFκB2 in the regulation of gene expression in response to viral infection. ..
  21. pmc IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner
    Bryce N Alves
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093
    J Immunol 192:3121-32. 2014
    ..This study illustrates the importance of kinetic considerations in understanding the functional specificity of negative-feedback regulators. ..
  22. pmc Functionally distinct effects of the C-terminal regions of IKKε and TBK1 on type I IFN production
    Yuichiro Nakatsu
    Department of Virology III, National Institute of Infectious Diseases, Musashi Murayama, Tokyo, Japan
    PLoS ONE 9:e94999. 2014
    ..The results highlight the importance of the C-terminal region in the functional activity of IKKε in innate immune response and also the difference in activation mechanisms between IKKε and the closely related TBK1...
  23. pmc IKKε knockout prevents high fat diet induced arterial atherosclerosis and NF-κB signaling in mice
    Changchun Cao
    Division of Nephrology, Department of Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
    PLoS ONE 8:e64930. 2013
    ..In this study we investigated the role of IKKε during the formation of atherosclerosis and its molecular mechanism in the mouse aortic vessel wall...
  24. pmc IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis
    Mihir Rajurkar
    Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts
    Cancer Res . 2017
    ..Here, we show that the noncanonical IκB-related kinase, IKBKE, is a critical oncogenic effector during KRAS-induced pancreatic transformation...
  25. pmc IKBKE phosphorylation and inhibition of FOXO3a: a mechanism of IKBKE oncogenic function
    Jian Ping Guo
    Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing, China
    PLoS ONE 8:e63636. 2013
    ..Here we report that IKBKE regulates FOXO3a through phosphorylation of FOXO3a-Ser644...
  26. doi Deficiency of IKKε inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice
    Changchun Cao
    Department of Nephrology, Nanjing Hospital affiliated to Nanjing Medical University, Nanjing, Jiangsu 210006, P R China
    Int J Mol Med 34:244-52. 2014
    ....
  27. doi IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity
    Laís Weissmann
    Department of Internal Medicine, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Diabetes 63:3334-45. 2014
    b>IKK epsilon (IKKε) is induced by the activation of nuclear factor-κB (NF-κB). Whole-body IKKε knockout mice on a high-fat diet (HFD) were protected from insulin resistance and showed altered energy balance...
  28. pmc Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response
    Ricardo Rajsbaum
    Department of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Immunity 40:880-95. 2014
    ..Our work attributes a previously unrecognized activating role of K48-linked unanchored polyubiquitin chains in kinase activation and identifies the UbE2K-TRIM6-ubiquitin axis as critical for IFN signaling and antiviral response. ..
  29. doi IκB kinase epsilon expression in adipocytes is upregulated by interaction with macrophages
    Yohei Sanada
    a Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima, Japan
    Biosci Biotechnol Biochem 78:1357-62. 2014
    ..This study provides novel insight into IKKε, which is involved in adipose tissue inflammation during the development of obesity. ..
  30. doi miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway
    Yu Zhang
    Department of Neurology, The First Affiliated School of Harbin Medical University, Harbin 150001, China
    Biochem Biophys Res Commun 452:450-6. 2014
    ..miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity. ..
  31. pmc Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation
    Meghana N Patel
    Department of Clinical Biochemistry and University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom
    Proc Natl Acad Sci U S A 112:506-11. 2015
    ..Here, we show that inhibitor of κB kinase epsilon (IKBKE) is a novel regulator that limits chronic inflammation during metabolic disease and atherosclerosis...
  32. pmc Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation
    Jiayi Yu
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
    Nat Commun 6:6074. 2015
    ..Treatment of mice with a small-molecule inhibitor of TBK1 inhibits EAE induction. These results suggest a role for TBK1 in regulating T-cell migration and establish TBK1 as a regulator of the AKT-mTORC1 signalling axis. ..
  33. doi A role for APPL1 in TLR3/4-dependent TBK1 and IKKε activation in macrophages
    Tieu Lan Chau
    Interdisciplinary Cluster of Applied Genoproteomics, GIGA Research, Hospital University of Liege Sart Tilman, University of Liege, 4000 Liege, Belgium Laboratory of Medical Chemistry, Hospital University of Liege Sart Tilman, University of Liege, 4000 Liege, Belgium Unit of Signal Transduction, GIGA Research, Hospital University of Liege Sart Tilman, University of Liege, 4000 Liege, Belgium
    J Immunol 194:3970-83. 2015
    ..Those signaling pathways involve the signal-induced degradation of APPL1 to prevent aberrant IRF3-dependent gene expression linked to immune diseases. ..
  34. pmc The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis
    Jinjin Xu
    Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics Ministry of Education, Institute of Biomedical Sciences, East China Normal University, Shanghai 200241, China
    Nat Commun 7:10761. 2016
    ..In sum, this study identifies REGγ-mediated control of IκBɛ as a molecular mechanism that contributes to NFκB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury. ..
  35. doi The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine
    Serkan Ismail Göktuna
    Interdisciplinary Cluster for Applied Genoproteomics GIGA, University of Liege, Liege, Belgium Laboratory of Medical Chemistry, GIGA Molecular Biology of Diseases, University of Liege, Liege, Belgium Department of Molecular Biology and Genetics, Bilkent University, Bilkent, Ankara, Turkey
    Cancer Res 76:2587-99. 2016
    ..Cancer Res; 76(9); 2587-99. ©2016 AACR. ..
  36. pmc IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response
    Junjie Zhang
    Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Cell Rep 16:405-18. 2016
    ..These results collectively show that IKKε promotes NFATc1 phosphorylation and inhibits T cell responses, identifying IKKε as a crucial negative regulator of T cell activation and a potential target for immunotherapy. ..
  37. doi Effects of IKKɛ on oxidised low-density lipoprotein-induced injury in vascular endothelial cells
    Changchun Cao
    Department of Nephrology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China
    Heart Lung Circ 22:366-72. 2013
    ..Oxidised low-density lipoprotein (ox-LDL) led to endothelial dysfunction, which was an initial step in the formation of atheroma. The role of IKKɛ in Ox-LDL-induced endothelial cell injury was investigated in this study...
  38. pmc Contribution of a TANK-binding kinase 1-interferon (IFN) regulatory factor 7 pathway to IFN-γ-induced gene expression
    Matthias Farlik
    Max F Perutz Laboratories, Department of Genetics, Microbiology and Immunobiology, University of Vienna, Vienna, Austria
    Mol Cell Biol 32:1032-43. 2012
    ..Our data thus describe a biologically relevant basal activity of TBK1 and identify IRF7 as a novel player in the IFN-γ response...
  39. pmc The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling
    Donald T Gracias
    Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Nat Immunol 14:593-602. 2013
    ..We have thus identified a previously unknown role for miR-155 in regulating responsiveness to interferon and CD8(+) T cell responses to pathogens in vivo...
  40. ncbi Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation
    Annie Bibeau-Poirier
    Faculty of Pharmacy, University of Montreal, Montreal, Canada
    J Immunol 177:5059-67. 2006
    ....
  41. pmc Inhibitor of κB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection
    Olivia Perwitasari
    Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 286:44412-23. 2011
    ..Our results define an IFN-induced IKKε signaling pathway of specific STAT1 phosphorylation and IFIT2 expression that imparts innate antiviral immunity to restrict WNV infection and control viral pathogenesis...
  42. pmc IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses
    Sze Ling Ng
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 108:21170-5. 2011
    ..We conclude that IKKε plays a critical role in regulating the balance between the IFN-I and IFN-II signaling pathways...
  43. pmc TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation
    Fangfang Qu
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Mol Cell Biol 32:3925-37. 2012
    ..Recently, inducible IκB kinase (IKKi) has been shown to phosphorylate Act1 on Ser 311 to mediate IL-17-induced mRNA stability...
  44. pmc Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance
    Muhammet F Gulen
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Immunity 37:800-12. 2012
    ..Via biochemical and genetic approaches, the kinases IKKi and GSK3α were identified as the critical intermediate signaling components for IL-1-induced AKT activation, which ..
  45. pmc IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis
    Yi Wang
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 110:11139-44. 2013
    ..Collectively, our findings uncover a critical IKKε in promoting NF-κB activation and tumorigenesis induced by a viral GPCR. ..
  46. pmc IKKi deficiency promotes pressure overload-induced cardiac hypertrophy and fibrosis
    Jia Dai
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
    PLoS ONE 8:e53412. 2013
    The inducible IκB kinase (IKKi/IKKε) is a recently described serine-threonine IKK-related kinase. Previous studies have reported the role of IKKi in infectious diseases and cancer...
  47. doi Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system
    Eddy T H Goh
    MRC Protein Phosphorylation Unit and Scottish Institute for Cell Signalling, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, U K
    Biochem J 441:339-46. 2012
    ..The activation of Pellino 1 provides the first direct readout for IRAK1 catalytic activity in cells...
  48. doi A novel IRAK1-IKKε signaling axis limits the activation of TAK1-IKKβ downstream of TLR3
    Daniela Bruni
    Institute of Immunology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland
    J Immunol 190:2844-56. 2013
    ....
  49. ncbi Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells
    Kosuke Matsui
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    J Immunol 177:5785-9. 2006
    TANK-binding kinase 1 (TBK1) and inducible IkappaB kinase (IKK-i) are involved in the activation of transcription factors inducing the production of type I IFNs...
  50. doi TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
    Ken J Ishii
    Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Agency JST
    Nature 451:725-9. 2008
    ..These data suggest that TBK1 is a key signalling molecule for DNA-vaccine-induced immunogenicity, by differentially controlling DNA-activated innate immune signalling through haematopoietic and non-haematopoietic cells...
  51. ncbi Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon
    Ahmet Civas
    UPR 2228 CNRS, Laboratoire de Régulation Transcriptionnelle et Maladies Génétiques, UFR Biomédicale des Saints Pères, Universite Paris V, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    J Biol Chem 281:4856-66. 2006
    ..during viral infection by the IKK-related serine/threonine kinases TBK1 and IkappaB kinase epsilon (IKKepsilon)...
  52. ncbi A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    Ken J Ishii
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 7:40-8. 2006
    ..the promoter of the gene encoding interferon-beta through a signaling pathway that required the kinases TBK1 and IKKi, whereas there was substantial activation of transcription factor NF-kappaB independent of both TBK and IKKi...
  53. ncbi Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3
    Susan E Sweeney
    University of California San Diego, School of Medicine, La Jolla, CA 92093, USA
    Arthritis Rheum 56:743-52. 2007
    ..This study was designed to investigate the role of the IKK-related kinase IKKepsilon and IFN regulatory factor 3 (IRF-3) in the activation of antiviral genes in rheumatoid arthritis (RA).
  54. pmc The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes
    Olga V Savinova
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 34:591-602. 2009
    ..Our biochemical evidence suggests an assembly pathway in which kinetic mechanisms control NF-kappaB dimer formation via processing and assembly of large complexes that contain IkappaB activities...
  55. pmc NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway
    Tomohiro Watanabe
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 120:1645-62. 2010
    ..This in turn led to activation of TANK-binding kinase 1 (TBK1) and IkappaB kinase epsilon (IKKepsilon) and the subsequent activation of IFN regulatory factor 7 (IRF7)...
  56. pmc Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon
    Rita Moreno
    Institute of Biochemistry, Medical Faculty, Friedrichstrasse 24, Justus Liebig University, 35392 Giessen, Germany
    Nucleic Acids Res 38:6029-44. 2010
    ..In the nucleus, the kinase contributes to the expression of a subset of NF-κB-regulated genes, thus revealing a novel role of IKKε for the control of nuclear NF-κB activity...
  57. doi The role of TBK1 and IKKε in the expression and activation of Pellino 1
    Hilary Smith
    MRC Protein Phosphorylation Unit, The Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee, UK
    Biochem J 434:537-48. 2011
    ..Thus IKKε/TBK1 mediate the activation of Pellino 1's E3 ligase activity, as well as inducing the transcription of its gene and protein expression in response to TLR3 and TLR4 agonists...
  58. doi Low-dose endotoxin induces inflammation by selectively removing nuclear receptors and activating CCAAT/enhancer-binding protein δ
    Urmila Maitra
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Immunol 186:4467-73. 2011
    ..Taken together, these data reveal a distinct pathway preferentially used by low-dose endotoxin in initiating low-grade inflammation...