Genomes and Genes
Gene Symbol: Il12b
Description: interleukin 12b
Alias: Il-12b, Il-12p40, Il12p40, p40, interleukin-12 subunit beta, CLMF p40, IL-12 p40 subunit, IL-12 subunit p40, IL-23 subunit p40, cytotoxic lymphocyte maturation factor 40 kDa subunit, interleukin-12 p40 subunit
Publications158 found, 100 shown here
- IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responsesJ Magram
Department of Biotechnology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110, USA
Immunity 4:471-81. 1996..However, other phenomena associated with Th1 responses and cell-mediated immunity, i.e., IL-2 secretion and CTL generation, were not compromised in the absence of IL-12...
- Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipidsChristophe Paget
Institut National de la Recherche Médicale, U547, 59019 Lille, France
Immunity 27:597-609. 2007..These data underline the role of TLR9 in iNKT cell activation and might have relevance to infectious diseases and cancer...
- IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelinationBruno Gran
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 169:7104-10. 2002..IL-12 is a heterodimeric cytokine, composed of a p40 and a p35 subunit, which is thought to play an important role in the development of Th1 cells and can exacerbate ..
- CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPSDimitris Skokos
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
J Exp Med 204:1525-31. 2007..Thus, activation of the two DC subsets by TLR4 leads to Th1 responses by two distinct MyD88-dependent pathways...
- mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPSHeth R Turnquist
Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, PA, USA
Blood 115:4758-69. 2010..Thus, GSK-3 activity in DC is regulated via signaling linked to mTOR and modulates their capacity both to produce IL-12p40/p70 and induce forkhead box p3 in CD4(+) T cells under inflammatory conditions...
- Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in miceMarcel Wuthrich
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
J Clin Invest 121:554-68. 2011..These data suggest that human vaccines against systemic fungal infections should be designed to induce Th17 cells if they are to be effective...
- IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and menE Jouanguy
Institut National de la Santé et de la Recherche Médicale Unité 429, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015, Paris, France, EU
Curr Opin Immunol 11:346-51. 1999..The axis formed between IL-12 and IFN-gamma is essential for protective immunity against mycobacteria and salmonella in mice and men...
- IL-12 is required to maintain a Th1 response during Leishmania major infectionA Y Park
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
J Immunol 165:896-902. 2000..To address this question, we infected IL-12 p40-/- C57BL/6 mice with Leishmania major, an intracellular protozoan parasite controlled by a cell-mediated immune ..
- Invariant NKT cells amplify the innate immune response to lipopolysaccharideNiranjana A Nagarajan
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
J Immunol 178:2706-13. 2007....
- Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profileKarina R B Bastos
Department of Immunology, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Brazil
J Leukoc Biol 71:271-8. 2002..These findings raise the possibility that IL-12 has a central role in driving macrophage polarization, regulating their intrinsic ability to respond against intracellular parasites...
- The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient micePiers Davenport
Centre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre Level 5 Block E, 246 Clayton Road, Clayton, Victoria, Australia 3168
Am J Pathol 163:1117-25. 2003..05). This suggests that both Th1 and Th2 cytokines play roles throughout the development of atherosclerosis in various vascular sites in apoE(-/-) mice...
- The Pro-Th1 cytokine IL-12 enhances IL-4 production by invariant NKT cells: relevance for T cell-mediated hepatitisRen Zhu
Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8147, Universite Paris V, Hopital Necker, 161 rue de Sevres, 75783 Paris Cedex 15, France
J Immunol 178:5435-42. 2007..Taken together, our findings provide the first evidence that IL-12 can enhance the immune response through increased IL-4 production by iNKT cells, underscoring once more the functional plasticity of this subset...
- IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient miceN J Davidson
DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, CA 94304, USA
J Immunol 161:3143-9. 1998....
- Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infectionKhuong B Nguyen
Deparment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
J Immunol 169:4279-87. 2002....
- TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivoPhilip W Askenase
Sections of Allergy and Clinical Immunology and Cardiology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 175:6390-401. 2005..The result is polyclonal IgM Ab responses capable of recruiting Ag-specific T cells into tissues. This may be involved in the promotion of autoimmunity by infectious agents...
- IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 promoter activity in macrophagesAtsuko Masumi
Department of Safety Research on Biologics, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashimurayama shi, Tokyo, Japan
FEBS Lett 531:348-53. 2002..Together, these results indicate that ICSBP and IRF-1 cooperatively stimulate murine IL-12 transcription through a novel regulatory element in the murine promoter...
- The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virusStephan Ehl
Children s Hospital, University of Freiburg, Freiburg, Germany
Eur J Immunol 34:1146-53. 2004..These findings clearly argue against a significant role for TLR4 and define a limited role for IL-12 in primary murine RSV infection...
- Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responsesE Cenci
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
J Infect Dis 180:1957-68. 1999..fumigatus by inhibition of protective Th1 responses. IL-4 appears to have a distinct role in the pathogenesis of allergic and nonallergic lung diseases caused by the fungus...
- Cutting edge: polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cellsAndrew S MacDonald
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Immunol 168:3127-30. 2002..These data help delineate the source and importance of IL-4 and IL-12 in the process of induction of polarized T cell responses by DC...
- Contribution of IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: a comparative study with IL-12p40Yuki Kinjo
Faculty of Medicine, First Department of Internal Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
J Immunol 169:323-9. 2002..Taken together, our results indicate that IL-18 plays an important role in Th1 response and host defense against M. tuberculosis infection although the contribution was not as profound as that of IL-12p40...
- Negative regulation of Toll-like-receptor signaling by IRF-4Hideo Negishi
Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
Proc Natl Acad Sci U S A 102:15989-94. 2005..This study may provide an insight into the complex regulatory mechanisms of MyD88 signaling by IRFs...
- CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4Naoko Ueda
Laboratory of Developmental Immunology, Graduate School of Medicine and Graduate School of Frontier Biosciences, Osaka University, 565 0871 Osaka, Japan
Int Immunol 18:1397-404. 2006..Thus, these results showed the 'involvement' of IL-4 that is produced from activated NKT cells for CD8+ T cell homeostatic proliferation in vivo...
- IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in miceMark S Wilson
Immunopathogenesis Section, Laboratory of Parasitic Diseases, and Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, Maryland, USA
J Clin Invest 117:2941-51. 2007..Thus, IL-10 and IL-13Ralpha2 are both required to control chronic Th2-driven pathological responses...
- VCAM-1 and VLA-4 modulate dendritic cell IL-12p40 production in experimental visceral leishmaniasisAmanda C Stanley
Queensland Institute of Medical Research, Herston, Queensland, Australia
PLoS Pathog 4:e1000158. 2008..These data indicate a role for VCAM-1 and VLA-4 in DC activation during infectious disease...
- Regulation of interleukin 12 p40 expression through an NF-kappa B half-siteT L Murphy
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Mol Cell Biol 15:5258-67. 1995..Control of IL-12 p40 expression is therefore important for understanding resistance and susceptibility to a variety of pathogens, ..
- Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factorR E Ploemacher
Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
Leukemia 7:1374-80. 1993..The observed activity of IL-12, however, required the presence of a least two factors, i.e. either IL-3 + IL-11, or IL-3 + SF...
- Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitisT K Tarrant
Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD 20892, USA
J Immunol 161:122-7. 1998..We, therefore, investigated whether endogenous IL-12 is required for development of EAU. IL-12 p40-deficient mice (12KO) were resistant to EAU induced with the uveitogenic retinal Ag interphotoreceptor retinoid ..
- IL-12 is not required for induction of type 1 cytokine responses in viral infectionsA Oxenius
Institute of Experimental Immunology, Department of Pathology, University of Zurich, Switzerland
J Immunol 162:965-73. 1999....
- Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyC Teuscher
Department of Veterinary Pathobiology, University of Illinois at Urbana Champaign 61802, USA
J Immunol 163:2262-6. 1999....
- Differential tumor surveillance by natural killer (NK) and NKT cellsM J Smyth
Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin and Repatriation Medical Centre, Heidelberg, 3084 Victoria, Australia
J Exp Med 191:661-8. 2000..This is the first description of an antitumor function for NKT cells in the absence of exogenously administered potent stimulators such as IL-12 or alpha-galactosylceramide...
- IL-12p40(-/-) mice treated with intratracheal bleomycin exhibit decreased pulmonary inflammation and increased fibrosisHideo Sakamoto
Immunopathology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Exp Mol Pathol 72:1-9. 2002..We conclude that IL-12 promotes the lymphohistiocytic response to BLM and may inhibit the late development of pulmonary fibrosis...
- Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient miceChris K F Li
Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, UK
J Immunol 173:5171-9. 2004..These studies show that mucosal remodeling can occur in the absence of MMP3, but that MMP3 plays a role in the migration of CD4+ T lymphocytes to the intestinal mucosa...
- Mice overexpressing p40 in lungs have reduced leucocyte influx and slightly impaired resistance during tuberculosisJaklien C Leemans
Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Immunology 117:409-18. 2006Interleukin (IL)-12 (p70) is a heterodimeric cytokine composed of p40 and p35, that plays a major role in the protective immune response to Mycobacterium tuberculosis. To define the role of p40 in lungs during pulmonary M...
- NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCsUlrike Schleicher
Institute of Medical Microbiology and Hygiene, University of Freiburg, D 79104 Freiburg, Germany
J Exp Med 204:893-906. 2007....
- Signal 3 availability limits the CD8 T cell response to a solid tumorJulie M Curtsinger
Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 178:6752-60. 2007....
- Recombinant interleukin 12 cures mice infected with Leishmania majorF P Heinzel
Department of Medicine, Case Western Reserve University, Cleveland, Ohio
J Exp Med 177:1505-9. 1993..Because rMuIL-12 is uniquely protective in this well-characterized model of chronic parasitism, differences in IL-12 production may underlie heterogenous host responses to L. major and other intracellular pathogens...
- Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosisA M Cooper
Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA
J Exp Med 186:39-45. 1997..To address the role of IL-12 in immunity to tuberculosis, IL-12 p40(-/-) mice were infected with M...
- Defective NK cell activity and Th1 response in IL-18-deficient miceK Takeda
Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
Immunity 8:383-90. 1998..We therefore generated mice lacking both IL-18 and IL-12. In these mice, NK activity and Th1 response were further impaired. This demonstrates the important role of both IL-18 and IL-12 in NK activity, as well as in in vivo Th1 response...
- Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoniK F Hoffmann
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
J Immunol 163:927-38. 1999..These results suggest that optimal vaccine-induced immunity against schistosomes is linked not to the development of a highly polarized response, but, rather, to the induction of both type 1- and type 2-associated immune responses...
- Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosisJinkyung Ko
Laboratory of Cellular and Molecular Immunology, Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
J Immunol 168:2433-40. 2002....
- In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) settingDragana Jankovic
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 16:429-39. 2002....
- Resistant mice lacking interleukin-12 become susceptible to Trypanosoma cruzi infection but fail to mount a T helper type 2 responseAna Paula Galvão Da Silva
Departamento de Patologia, Centro de Ciencias da Saude, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil
Immunology 108:230-7. 2003..cruzi (Y strain) infection and the regulation of cytokine responses and nitric oxide production in C57BL/6 IL-12 p40-knockout mice...
- Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainDaniel J Cua
Department of Immunology, DNAX Research Inc, Palo Alto, California 94304 1104, USA
Nature 421:744-8. 2003Interleukin-12 (IL-12) is a heterodimeric molecule composed of p35 and p40 subunits...
- Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient miceNico Ghilardi
Department of Molecular Biology, Genentech, South San Francisco, CA 94080, USA
J Immunol 172:2827-33. 2004..heterodimeric cytokine IL-23 consists of a private cytokine-like p19 subunit and a cytokine receptor-like subunit, p40, which is shared with IL-12...
- IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12Linda A Lieberman
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 173:1887-93. 2004IL-23 and IL-12 are heterodimeric cytokines which share the p40 subunit, but which have unique second subunits, IL-23p19 and IL-12p35...
- Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogensYan Zheng
Department of Immunology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
Nat Med 14:282-9. 2008..rodentium infection. Together, our data identify a new innate immune function for IL-22 in regulating early defense mechanisms against A/E bacterial pathogens...
- Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migrationRichard T Robinson
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 181:5560-7. 2008..pestis grown at 26 degrees C (Y. pestis-26 degrees), they secrete copious amounts of IL-12p40 homodimer (IL-12(p40)(2)). In contrast, when DCs are exposed to Y. pestis grown at 37 degrees C (Y...
- IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposureY Onari
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Clin Exp Allergy 39:290-8. 2009..We previously reported a mouse model of bronchial asthma showing eosinophilic inflammation, but not airway hyperresponsiveness (AHR), after prolonged antigen exposure. This model showed an increase of IL-12 in the lung...
- Cloning and expression of murine IL-12D S Schoenhaut
Department of Molecular Genetics, Roche Research Center, Hoffmann La Roche Inc, Nutley, NJ 07110 1197
J Immunol 148:3433-40. 1992..of the predicted amino acid sequences of the murine subunits with their human counterparts revealed that the p40 subunits are more highly conserved than the p35 subunits (70% vs 60% identity, respectively)...
- Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant miceF P Heinzel
Division of Geographic Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
J Immunol 155:730-9. 1995..Furthermore, the uninhibited production of IL-4 was required to sustain progressive infection initiated by the decreased IFN-gamma synthesis observed in anti-IL-12 and anti-IFN-gamma-treated mice...
- IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infectionJ L Flynn
Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Immunol 155:2515-24. 1995..tuberculosis-infected gko mice, transgenic mice in which the IFN-gamma gene has been disrupted, indicating that IL-12 does not induce protection against tuberculosis in mice in the absence of IFN-gamma...
- Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophagesC S Hsieh
Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
Science 260:547-9. 1993..Therefore, this regulatory pathway may have evolved to enable innate immune cells, through interactions with microbial pathogens, to direct development of specific immunity toward the appropriate TH phenotype...
- Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell developmentM L Guler
Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
Science 271:984-7. 1996..D2 T cells. Thus, susceptibility of BALB/c mice to infection with L. major may derive from the loss of the ability to generate IL-12-induced TH1 responses rather than from an IL-4-induced TH2 response...
- Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell responseF Mattner
Department of Infectious Diseases, F Hoffmann La Roche AG, Basel, Switzerland
Eur J Immunol 26:1553-9. 1996Mice with homologous disruption of the gene coding for either the p35 subunit or the p40 subunit of interleukin-12 (IL-12) and derived from a strain genetically resistant to infection with Leishmania major have been used to study further ..
- Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient miceK W McIntyre
Department of Inflammation Autoimmune Diseases, Hoffmann La Roche Inc, Nutley, NJ 07110, USA
Eur J Immunol 26:2933-8. 1996..Taken together, these results demonstrate an important role for IL-12 in the pathogenesis of CIA, although it is not absolutely required for disease development...
- Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 inductionT Scharton-Kersten
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
J Exp Med 186:1523-34. 1997..and in vivo revealed a major deficiency in the expression of both interferon (IFN)-gamma and interleukin (IL)-12 p40 in the T. gondii exposed ICSBP-/- animals...
- Expression of murine IL-12 is regulated by translational control of the p35 subunitJ M Babik
Sir William Dunn School of Pathology, University of Oxford, United Kingdom
J Immunol 162:4069-78. 1999IL-12 is a heterodimer of two subunits, p35 and p40, encoded by separate genes that are regulated independently...
- IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathologyA R Satoskar
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston 02115, USA
Eur J Immunol 30:834-9. 2000..These findings indicate that although endogenous IL-12 is critical for the development of protective immunity to L. donovani, it is also responsible for inducing the significant immunopathology associated with visceral leishmaniasis...
- IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasisK F Hoffmann
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 164:6406-16. 2000....
- Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12B Oppmann
DNAX Research Institute, Palo Alto, CA 94304, USA
Immunity 13:715-25. 2000..This factor, which we term p19, shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a novel, biologically active, composite cytokine, which we term IL-23...
- Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasisS E Street
Cancer Immunology, Peter MacCallum Cancer Institute, Victoria, Australia
Blood 97:192-7. 2001....
- A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatmentG S Yap
Laboratories of Parasitic Diseases and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 166:5720-5. 2001..Q/J mice can result in defective host resistance and demonstrate a therapeutic function for IL-18 in reversing a genetically based immunodeficiency in IL-12-dependent IFN-gamma production...
- Enhanced gamma interferon production through activation of Valpha14(+) natural killer T cells by alpha-galactosylceramide in interleukin-18-deficient mice with systemic cryptococcosisK Kawakami
First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
Infect Immun 69:6643-50. 2001..Our results indicated that in IL-18KO mice, IFN-gamma synthesis was enhanced through overproduction of IL-12 and IL-4 after intravenous infection with C. neoformans and a ligand-specific activation of Valpha14(+) NKT cells...
- A protective and agonistic function of IL-12p40 in mycobacterial infectionC Holscher
Medical Research Council Unit Immunology in Infectious Diseases, Department of Immunology, University of Cape Town, Cape Town, South Africa
J Immunol 167:6957-66. 2001IL-12p35(-/-)p40(-/-) mice are highly susceptible to Mycobacterium bovis bacillus Calmette-Guérin (BCG) or Mycobacterium tuberculosis infection. In this study IL-12p35(-/-) mice, which are able to produce endogenous IL-12p40, cleared M...
- Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is presentAndrea M Cooper
Mycobacteria Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
J Immunol 168:1322-7. 2002..To determine whether this is the case in tuberculosis, both p35 and p40 knockout mice were infected with Mycobacterium tuberculosis...
- Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 productionCaroline Demangel
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
Eur J Immunol 32:994-1002. 2002....
- IL-12: the role of p40 versus p75K Abdi
Ghost Laboratory, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville Pike, Bethesda, MD 20892 0420, USA
Scand J Immunol 56:1-11. 2002..IL)-12p75 is a heterodimeric cytokine composed of the product of two different genes that specify p35 and p40 subunits...
- Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signalingMarina A Freudenberg
Max Planck Institut fur Immunbiologie, Freiburg, Germany
J Immunol 169:1665-8. 2002..This pathway participates in the induction of IFN-gamma by Gram-negative bacteria and is therefore expected to play a role whenever IFN-alpha or IFN-beta and IL-18 are produced concomitantly during bacterial, viral, or other infections...
- Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12Burkhard Becher
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Clin Invest 110:493-7. 2002..IL-12 is a heterodimer composed of a p35 subunit and a common p40 subunit shared by other cytokines. Both IL-12 p40(-/-) and p35(-/-) mice fail to produce IL-12 p70 heterodimer...
- A profibrotic function of IL-12p40 in experimental pulmonary fibrosisFrancois Huaux
Units of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, Brussels, Belgium
J Immunol 169:2653-61. 2002The p40 subunit of IL-12 (IL-12p40), but not the heterodimeric form IL-12p70, is secreted during the development of silica-induced lung fibrosis in C57BL/6 mice...
- ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitroHideki Tsujimura
Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health NIH, Bethesda, MD 20892, USA
Blood 101:961-9. 2003..did not mature in response to activation signals, and failed to express CD8alpha and interleukin 12 (IL-12) p40, a feature consistent with ICSBP(-/-) DCs in vivo...
- Identification of IFN regulatory factor-1 binding site in IL-12 p40 gene promoterSaho Maruyama
Department of Immunology and Host Defenses, Ehime University School of Medicine, Shigenobu, Japan
J Immunol 170:997-1001. 2003IL-12 is a heterodimer composed of p40 and p35 and is a key cytokine that functions to protect the host from viral and microbial infections...
- Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependentLaurence U Buxbaum
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA
Eur J Immunol 32:3206-15. 2002..These data uncover the existence of an alternate IFN-gamma and iNOS pathway for control of Leishmania lesions, which is IL-12 independent, but which unexpectedly requires STAT4...
- Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathwayMasahiro Yamamoto
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
Science 301:640-3. 2003..These findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense...
- Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophagesMalabendu Jana
Department of Oral Biology, University of Nebraska Medical Center, Lincoln, Nebraska 68583 0740, USA
J Neurochem 86:519-28. 2003The present study was undertaken to explore the role of interleukin-12 (IL-12) p40 in the expression of TNF-alpha in microglia...
- Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBPChen Zhu
Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 278:39372-82. 2003..The IL-12 p40 gene product, expressed specifically in macrophages and dendritic cells, heterodimerizes with p35 to form bioactive ..
- IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infectionShan Ze Wang
Asthma and Pulmonary Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
J Immunol 173:4040-9. 2004..These findings implicate a role for IL-12 and IL-18 in modulating respiratory syncytial virus-induced airway inflammation distinct from that of viral clearance...
- A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycanJoseph L Amprey
Department of Medicine, Weill College of Medicine, Cornell University, New York, NY 10021, USA
J Exp Med 200:895-904. 2004..Together, these data identify Leishmania surface glycoconjugates as potential glycolipid antigens and suggest an important role for the CD1d-NK T cell immune axis in the early response to visceral Leishmania infection...
- IL-23 drives a pathogenic T cell population that induces autoimmune inflammationClaire L Langrish
Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
J Exp Med 201:233-40. 2005Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a common p40 subunit shared with IL-12...
- Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 productionCarl G Feng
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8003, USA
J Immunol 174:4185-92. 2005..tuberculosis infection and suggest that breakdown of this mechanism could be a contributing factor in reactivated disease...
- IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is availableShabaana A Khader
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
J Immunol 175:788-95. 2005....
- Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophagesSushil Kumar Pathak
Department of Chemistry, Bose Institute, 93 1 Acharya Prafulla Chandra Road, Kolkata 700009, India
J Biol Chem 280:42794-800. 2005..tuberculosis. We demonstrate that Man-LAM inhibits IL-12 p40 production mediated by subsequent challenge with lipopolysaccharide (LPS)...
- Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malariaIrene Gramaglia
La Jolla Bioengineering Institute, La Jolla, CA 92037, USA
J Immunol 175:7699-707. 2005....
- The IL-21 receptor augments Th2 effector function and alternative macrophage activationJohn Pesce
Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Invest 116:2044-55. 2006..Collectively, these results illustrate an essential function for the IL-21R in the development of pathogen-induced Th2 responses, which may have relevance in therapies for both inflammatory and chronic fibrotic diseases...
- Responses to Leishmania donovani in mice deficient in interleukin-12 (IL-12), IL-12/IL-23, or IL-18Henry W Murray
Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Infect Immun 74:4370-4. 2006..Nevertheless, testing in IL-18(-/-) mice compared to wild-type mice and in IL-12p40(-/-) compared to IL-12p35(-/-) mice also suggested both early-acting (IL-18) and late-acting (IL-23) antileishmanial effects independent of IL-12...
- Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infectionShabaana A Khader
Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
J Exp Med 203:1805-15. 2006..Treatment of IL-12p40-deficient DCs with IL-12p40 homodimer (IL-12(p40)(2)) restores Mtb-induced DC migration and the ability of IL-12p40-deficient DCs to activate naive T cells...
- Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitisChristoph Becker
Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
J Immunol 177:2760-4. 2006Although IL-12 and IL-23 share the common p40 subunit, IL-23, rather than IL-12, seems to drive the pathogenesis of experimental autoimmune encephalomyelitis and arthritis, because IL-23/p19 knockout mice are protected from disease...
- IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challengeShabaana A Khader
Trudeau Institute, Saranac Lake, New York 12983, USA
Nat Immunol 8:369-77. 2007....
- A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivoHelena Soares
Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10021, USA
J Exp Med 204:1095-106. 2007..The results indicate that two DC subsets have innate propensities to differentially affect the Th1/Th2 balance in vivo and by distinct mechanisms...
- IL-23 enhances host defense against vaccinia virus infection via a mechanism partly involving IL-17Shunsuke Kohyama
Department of Microbiology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
J Immunol 179:3917-25. 2007..Unveiling of an alternative pathway in the IL-23-regulated resistance might provide a novel strategy against infectious pathogens without side effects of autoimmunity...
- Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector categoryDror Luger
Laboratory of Immunology, National Eye Institute NEI, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Exp Med 205:799-810. 2008..These data also raise the possibility that the nonredundant requirement for IL-23 in EAU may extend beyond its role in promoting the Th17 effector response and help provide a balance in the current Th1 versus Th17 paradigm...
- Cutting edge: the mechanism of invariant NKT cell responses to viral danger signalsAaron J Tyznik
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Immunol 181:4452-6. 2008..Consequently, iNKT cells have the ability to respond to a variety of microbes, including viruses, in an Ag-independent manner, suggesting they may play a broad role in antipathogen defenses despite their limited TCR repertoire...
- Interleukin-12p40 contributes to protection against lung injury after oral Yersinia enterocolitica infectionJ G Gutierrez
Laboratorio de Bioquímica Molecular Universidad Nacional de San Luis Chacabuco y Pedernera, 5700, San Luis, Argentina
Inflamm Res 57:504-11. 2008..The impact of Yersinia enterocolitica on lung is incompletely understood, so we studied the inflammatory effects of Yersinia oral infection and the influence of IL-12p40 deficiency...
- Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17Silke M Schulz
Institute of Immunology, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany
J Immunol 181:7891-901. 2008..In conclusion, IL-23-dependent IL-22, but not IL-17 production is associated with protection against systemic infection with S. Enteritidis in the absence of IL-12...
- Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II miceKatsunori Yoshida
Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA 95616, USA
Hepatology 50:1494-500. 2009....
- Neurodegeneration and increased production of nitrotyrosine, nitric oxide synthase, IFN-gamma and S100beta protein in the spinal cord of IL-12p40-deficient mice infected with Trypanosoma cruziAndré Luis Bombeiro
Department of Immunology, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil
Neuroimmunomodulation 17:67-78. 2010..In the current work, we studied the expression of NO, interferon (IFN)-gamma and S100beta in the spinal cord tissue of IL-12p40KO mice infected with T. cruzi, a model of neurodegenerative process...
- IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasisMichele W L Teng
Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
Proc Natl Acad Sci U S A 107:8328-33. 2010..Overall, these data indicate the general role that IL-23 plays in suppressing natural or cytokine-induced innate immunity, promoting tumor development and metastases independently of IL-17A...
- Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in miceA G Castro
Center for Experimental Cytology, University of Porto, Portugal
J Immunol 155:2013-9. 1995..Finally, animals whose IL-12 was blocked expressed heightened levels of IL-4 and IL-10 message and reduced expression of IFN-gamma as compared with control mice...
- Interleukin-12 synergizes with interleukin-3 and steel factor to enhance recovery of murine hemopoietic stem cells in liquid cultureR E Ploemacher
Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
Leukemia 7:1381-8. 1993..These data show that IL-12 interacts with IL-3 and SF to regulate survival and growth of myeloid stem cells and progenitor cells...
- IL-12 is a central mediator of acute graft-versus-host disease in miceE Williamson
Department of Immunology, Western Infirmary, University of Glasgow, Scotland
J Immunol 157:689-99. 1996....
- Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesisC M Coughlin
Biomedical Graduate Program, Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 101:1441-52. 1998..This suggests that inhibition of tumor angiogenesis is an important part of the systemic antitumor effect produced by mIL-12 and mIL-18...
- ROLE OF PKD IN LEUKOCYTE ACTIVATION BY CPG DNAAe Kyung Yi; Fiscal Year: 2002..This proposed study would enhance our understanding of how CpG motifs in bacterial DNA break immune tolerance and contribute to chrome inflammatory autoimmune diseases such as arthritis. ..
- Role of IL-10 in Periodontal Bone DestructionHajime Sasaki; Fiscal Year: 2005..The long-term goal is to determine the preventive role of lL-10 in periodontitis, and to apply this information to the development of modulators that ameliorate this disease. ..
- HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPYHenry Murray; Fiscal Year: 2005..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
- Impact of chronic infection in the aged on the response to vaccinationAndrea Cooper; Fiscal Year: 2007..These experiments are relevant to human health since determining the effect of inflammation on the response to vaccination will allow us to improve vaccination in the elderly. [unreadable] [unreadable] [unreadable] [unreadable]..
- Initiation of Contact and Asthmatic HypersensitivityPhilip Askenase; Fiscal Year: 2008..abstract_text> ..
- Induction of immunological paralysis by CpG DNAAe Kyung Yi; Fiscal Year: 2008..abstract_text> ..
- The role of IL-12p40 in the response of pulmonary dendritic cells to tuberculosisAndrea M Cooper; Fiscal Year: 2010..This increased understanding will allow targeted and novel interventions that will improve our ability to control disease. ..
- IMMUNOPATHOGENESIS OF MYCOBACTERIUM AVIUM DISEASEAndrea Cooper; Fiscal Year: 2001..Finally, they will test the hypothesis that appropriate chemotherapy can restore the correct immunologic functions/signals, using both established regimens, as well as new compounds recently identified in their laboratory as active. ..
- Host Immunoregulation of Response to Antileishmanial ChemotherapyHenry Murray; Fiscal Year: 2007..abstract_text> ..