Il7

Summary

Gene Symbol: Il7
Description: interleukin 7
Alias: A630026I06Rik, Il-7, hlb368, interleukin-7
Species: mouse

Top Publications

  1. pmc Transgenic mice in the study of cytokine function
    J Taverne
    University College London Medical School, Department of Immunology, UK
    Int J Exp Pathol 74:525-46. 1993
  2. pmc Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
    U von Freeden-Jeffry
    Department of Immunology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    J Exp Med 181:1519-26. 1995
  3. ncbi Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during development
    Y Chang
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032
    J Neuroimmunol 52:9-17. 1994
  4. ncbi IL-15 is an essential mediator of peripheral NK-cell homeostasis
    Thomas Ranson
    Unité des Cytokines et Développement Lymphoide, Institut Pasteur, Paris, France
    Blood 101:4887-93. 2003
  5. ncbi Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, Institut Nationale de la Santé et Recherche Médicale Equipe 101, Institut Pasteur, Paris, France
    J Immunol 174:1213-21. 2005
  6. pmc Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype
    Deirdre D Scripture-Adams
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Virol 76:13077-82. 2002
  7. pmc Distinct progenitors for B-1 and B-2 cells are present in adult mouse spleen
    Eliver Eid Bou Ghosn
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:2879-84. 2011
  8. pmc SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential
    Gayle M Davey
    The Walter and Eliza Hall Institute of Medical Research, Parkville, 3050 Victoria, Australia
    J Exp Med 202:1099-108. 2005
  9. ncbi Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis
    Takayuki Tomita
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 180:383-90. 2008
  10. pmc IL-7 is essential for homeostatic control of T cell metabolism in vivo
    Sarah R Jacobs
    Department of Pharmacology, Sarah W Stedman Center for Nutrition and Metabolism, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 184:3461-9. 2010

Research Grants

Scientific Experts

Detail Information

Publications128 found, 100 shown here

  1. pmc Transgenic mice in the study of cytokine function
    J Taverne
    University College London Medical School, Department of Immunology, UK
    Int J Exp Pathol 74:525-46. 1993
  2. pmc Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
    U von Freeden-Jeffry
    Department of Immunology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    J Exp Med 181:1519-26. 1995
    ..These data show that proper T and B cell development is dependent on IL-7. The IL-7-deficient mice are the first example of single cytokine-deficient mice that exhibit severe lymphoid abnormalities...
  3. ncbi Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during development
    Y Chang
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032
    J Neuroimmunol 52:9-17. 1994
    ....
  4. ncbi IL-15 is an essential mediator of peripheral NK-cell homeostasis
    Thomas Ranson
    Unité des Cytokines et Développement Lymphoide, Institut Pasteur, Paris, France
    Blood 101:4887-93. 2003
    ..Using an adoptive transfer system, we have investigated the role of gammac-dependent cytokines, in particular interleukin 7 (IL-7) and IL-15, and major histocompatibility complex (MHC) class I molecules in peripheral NK-cell ..
  5. ncbi Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, Institut Nationale de la Santé et Recherche Médicale Equipe 101, Institut Pasteur, Paris, France
    J Immunol 174:1213-21. 2005
    ..Surprisingly, the few residual NK cells generated in absence of IL-15 appear relatively mature, expressing a variety of Ly49 receptors and demonstrating lytic and cytokine production capacity...
  6. pmc Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype
    Deirdre D Scripture-Adams
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Virol 76:13077-82. 2002
    ..Thus, IL-7 is a viable candidate to activate expression of latent HIV and may facilitate immune clearance of latently infected cells...
  7. pmc Distinct progenitors for B-1 and B-2 cells are present in adult mouse spleen
    Eliver Eid Bou Ghosn
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:2879-84. 2011
    ..In adults, in vivo inflammatory stimulation (LPS) triggers B-1 progenitors in spleen to expand and initiate development along this B-1 developmental pathway...
  8. pmc SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential
    Gayle M Davey
    The Walter and Eliza Hall Institute of Medical Research, Parkville, 3050 Victoria, Australia
    J Exp Med 202:1099-108. 2005
    ..Therefore, impaired deletion of highly autoreactive CD8 T cells, together with uncontrolled activation of naive CD8 T cells by homeostatic survival ligands, may provide a basis for the T cell-mediated disease of SOCS-1-/- mice...
  9. ncbi Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis
    Takayuki Tomita
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 180:383-90. 2008
    ....
  10. pmc IL-7 is essential for homeostatic control of T cell metabolism in vivo
    Sarah R Jacobs
    Department of Pharmacology, Sarah W Stedman Center for Nutrition and Metabolism, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 184:3461-9. 2010
    ....
  11. ncbi Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis
    Sheela Ramanathan
    Immunology Division, Department of Pediatrics, Faculty of Medicine, University of Sherbrooke, Canada
    J Immunol 176:4029-41. 2006
    ..Our findings illustrate distinct functions for IL-7 and IL-15 in T lymphocyte development and homeostasis, and stringent regulation of these processes by SOCS1...
  12. doi IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors
    Panagiotis Tsapogas
    Department of Clinical and Experimental Medicine, Experimental Hematopoiesis Unit, Faculty for Health Sciences, Linkoping University, Linkoping, Sweden
    Blood 118:1283-90. 2011
    ..This reveals that IL-7 is essential for normal development of Ly6D(+) CLPs and that Ebf-1 is crucial for lineage restriction in early lymphoid progenitors...
  13. ncbi Interleukin-1 and its biologically related cytokines
    C A Dinarello
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111
    Adv Immunol 44:153-205. 1989
  14. ncbi A role for TCR affinity in regulating naive T cell homeostasis
    William C Kieper
    Department of Immunology, The Scripps Research Institute, 1 550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 172:40-4. 2004
    ..The results suggest that the strength of the TCR affinity determines the relative "fitness" of naive T cells to compete for factors that support cell survival and homeostatic proliferation...
  15. pmc Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells
    Shin ichiro Sawa
    Laboratory of Developmental Immunology, Graduate School of Frontier Bioscience and Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    J Exp Med 203:1459-70. 2006
    ....
  16. doi FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis
    Christina T Jensen
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    Blood 112:2297-304. 2008
    ..Thus, the same IL-7- and FLT3 ligand-mediated signal-ing regulates alternative pathways of fetal and adult B-1 and B-2 lymphopoiesis...
  17. doi Hepatic interleukin-7 expression regulates T cell responses
    Yukihisa Sawa
    Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Immunity 30:447-57. 2009
    ....
  18. ncbi Il-7 supports D-J but not V-DJ rearrangement of TCR-beta gene in fetal liver progenitor cells
    S Tsuda
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Japan
    J Immunol 156:3233-42. 1996
    ....
  19. ncbi Semi-quantitative polymerase chain reaction analysis of cytokine and cytokine receptor gene expression during thymic ontogeny
    R A Montgomery
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cytokine 9:717-26. 1997
    ..The mRNA abundance and pattern of expression of each cytokine or cytokine receptor may indicate the relative contribution that it makes to different stages of fetal thymic ontogeny...
  20. pmc The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7
    Juli P Miller
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 196:705-11. 2002
    ..These findings challenge previous notions regarding the point in B cell development affected by the loss of IL-7R signaling and suggest that IL-7 plays a key and requisite role during the earliest phases of B cell development...
  21. ncbi Interleukin-3 and interleukin-7 are alternative growth factors for the same B-cell precursors in the mouse
    T H Winkler
    Basel Institute for Immunology, Switzerland
    Blood 85:2045-51. 1995
    ..Thus, IL-7 and IL-3 are alternative growth factors for the same pre-BI cell...
  22. ncbi IL-7 overexpression in transgenic mouse keratinocytes causes a lymphoproliferative skin disease dominated by intermediate TCR cells: evidence for a hierarchy in IL-7 responsiveness among cutaneous T cells
    I R Williams
    Harvard Skin Disease Research Center, Division of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 159:3044-56. 1997
    ..Our results also suggest that features of the epidermal microenvironment besides keratinocyte-derived IL-7 account for the normal predominance of Vgamma5 Vdelta1 DETC in mouse epidermis...
  23. pmc Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells
    William C Kieper
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 195:1533-9. 2002
    ..Since these cell are rare in normal IL-15(-) mice, the dependency of memory phenotype CD8+ cells on IL-15 can be overcome by overexpression of IL-7...
  24. ncbi Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival
    Jung Hyun Park
    Experimental Immunology Branch, National Cancer Institute, Building 10 Room 4B36, Bethesda, Maryland 20892, USA
    Immunity 21:289-302. 2004
    ..We suggest that this homeostatic regulatory mechanism promotes survival of the maximum possible number of T cells for the amount of IL-7 available...
  25. ncbi Ontogeny and regulation of IL-7-expressing thymic epithelial cells
    Monica Zamisch
    Science Park Research Division, University of Texas M D Anderson Cancer Center, Smithville, TX 78957, USA
    J Immunol 174:60-7. 2005
    ....
  26. pmc Cutting edge: IL-7-independent regulation of IL-7 receptor alpha expression and memory CD8 T cell development
    Kimberly D Klonowski
    Department of Immunology, Center for Integrative Immunology and Vaccine Research, University of Connecticut Health Center, 2634 Farmington Avenue, Farmington, CT 06030, USA
    J Immunol 177:4247-51. 2006
    ..Thus, IL-7Ralpha regulation occurs independently of IL-7 in responding CD8 T cells, indicating that CD8 memory T cell precursors are not selected by IL-7/IL-7Ralpha interactions...
  27. ncbi Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells
    Dominik Meier
    Division of Developmental Immunology, Center for Biomedicine, Department of Clinical and Biological Sciences DKBW, University of Basel, CH 4058 Basel, Switzerland
    Immunity 26:643-54. 2007
    ..Therefore, by controlling LTi cell numbers, IL-7 can regulate the formation of both normal and ectopic lymphoid organs...
  28. pmc Visualization and identification of IL-7 producing cells in reporter mice
    Renata I Mazzucchelli
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD, USA
    PLoS ONE 4:e7637. 2009
    ..We produced a bacterial artificial chromosome (BAC) transgenic mouse expressing ECFP in the Il7 locus...
  29. pmc Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development
    Stephen Malin
    Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria
    Nat Immunol 11:171-9. 2010
    STAT5 and interleukin 7 (IL-7) signaling are thought to control B lymphopoiesis by regulating the expression of key transcription factors and by activating variable (V(H)) gene segments at the immunoglobulin heavy-chain (Igh) locus...
  30. pmc IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, 75724 Paris, France
    J Exp Med 207:273-80. 2010
    ..1(-)Rorc(+) cells are not canonical NK cell precursors. These studies highlight the independent cytokine regulation of functionally diverse intestinal NKp46(+) cell subsets...
  31. ncbi Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction
    R A Montgomery
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hosptial, Headington, England
    J Immunol 147:554-60. 1991
    ....
  32. ncbi Stimulation of B-cell progenitors by cloned murine interleukin-7
    A E Namen
    Immunex Corporation, Seattle, Washington 98101
    Nature 333:571-3. 1988
    ..Using direct expression in mammalian cells we have isolated a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7...
  33. ncbi Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor
    A R Venkitaraman
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, GB
    Eur J Immunol 24:2168-74. 1994
    ..PtdIns 3-kinase may, therefore, play a unique and important role in the biological response to IL-7...
  34. ncbi IL-7 stimulates protective immunity in mice against the intracellular pathogen, Toxoplasma gondii
    L H Kasper
    Department of Medicine, Dartmouth Medical School, Hanover, NH 03755, USA
    J Immunol 155:4798-804. 1995
    ..These observations indicate that exogenous administration of human rIL-7 is able to protect mice against acute parasite challenge by stimulating IFN-gamma production and augmenting the CD8+ T cell-mediated CTL response...
  35. ncbi Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice
    T A Moore
    Immunology Department, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 157:2366-73. 1996
    ..Together, these data clarify the developmental abnormalities during T cell development due to the absence of IL-7...
  36. ncbi The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression
    U von Freeden-Jeffry
    Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304, USA
    Immunity 7:147-54. 1997
    ..These data specify a T cell lineage developmental transition point, prior to T cell antigen receptor rearrangement, where IL-7 signal transduction is linked to an anti-apoptosis mechanism and the cell cycle...
  37. pmc The common cytokine receptor gamma chain controls survival of gamma/delta T cells
    M Malissen
    Centre d Immunologie Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique de Marseille Luminy, France
    J Exp Med 186:1277-85. 1997
    ....
  38. pmc Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa
    M Watanabe
    Keio Cancer Center, School of Medicine, Keio University, Tokyo 160, Japan
    J Exp Med 187:389-402. 1998
    We have demonstrated that intestinal epithelial cells produce interleukin 7 (IL-7), and IL-7 serves as a potent regulatory factor for proliferation of intestinal mucosal lymphocytes expressing functional IL-7 receptor...
  39. ncbi Cytokine gene expression in murine fetal intestine: potential for extrathymic T cell development
    A M Murray
    Discipline of Pathology, University of Newcastle, NSW, Australia
    Cytokine 10:337-45. 1998
    ..Stem cell factor (SCF) and interleukin 7 (IL-7) message was abundant in all three tissues during fetal development...
  40. ncbi The role of IL-7 in thymic and extrathymic development of TCR gamma delta cells
    K Laky
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    J Immunol 161:707-13. 1998
    ..Thus, intrathymic IL-7 was required for development of thymic TCR gamma delta cells, while peripheral IL-7 was sufficient for development of extrathymic TCR gamma delta IEL...
  41. ncbi Regulation of cell survival during B lymphopoiesis: apoptosis and Bcl-2/Bax content of precursor B cells in bone marrow of mice with altered expression of IL-7 and recombinase-activating gene-2
    L Lu
    Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
    J Immunol 162:1931-40. 1999
    ..The results demonstrate that IL-7 strongly promotes in vivo cell survival and maintains antiapoptotic Bcl-2/Bax ratios during the development of precursor B cells in mouse bone marrow...
  42. ncbi Murine pro-B cells require IL-7 and its receptor complex to up-regulate IL-7R alpha, terminal deoxynucleotidyltransferase, and c mu expression
    C Wei
    Department of Pathology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 164:1961-70. 2000
    ..These key events, in turn, appear to be prerequisite both for differentiation of pro-B cells to pre-B cells and for proliferation of these cell subsets upon continued stimulation with IL-7...
  43. ncbi Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
    K S Schluns
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nat Immunol 1:426-32. 2000
    ..Homeostatic proliferation of memory cells was also partially dependent on IL-7. These results point to IL-7 as a pivotal cytokine in T cell homeostasis...
  44. pmc IL-7 is critical for homeostatic proliferation and survival of naive T cells
    J T Tan
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:8732-7. 2001
    ..Thus, naïve T cells disappeared gradually over a 1-month period upon adoptive transfer into IL-7(-) hosts. These findings indicate that naive T cells depend on IL-7 for survival and homeostatic proliferation...
  45. pmc Arrested B lymphopoiesis and persistence of activated B cells in adult interleukin 7(-/)- mice
    T L Carvalho
    Instituto Gulbenkian de Ciencia, 2781 Oeiras, Portugal
    J Exp Med 194:1141-50. 2001
    b>Interleukin 7 is a crucial factor for the development of murine T and B lymphocytes...
  46. ncbi IL-7 enhances the survival and maintains the size of naive T cells
    J C Rathmell
    Department of Cancer Biology and Medicine and Abramson Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 167:6869-76. 2001
    ..These data demonstrate that T cells require the continuous presence of extrinsic signals not only to survive but also to maintain their size, metabolic activity, and the ability to respond rapidly to mitogenic signals...
  47. pmc Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells
    Ananda W Goldrath
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 195:1515-22. 2002
    ..Our results show that naive and memory T lymphocytes differ in their cytokine dependence for acute homeostatic proliferation and that memory T lymphocytes have distinct requirements for proliferation in full versus empty compartments...
  48. pmc Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells
    Joyce T Tan
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 195:1523-32. 2002
    ..Thus, the homeostatic proliferation mechanisms that control memory CD8+ cells and memory CD4+ cells are quite distinct...
  49. pmc Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency
    M Neale Weitzmann
    Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, Missouri, USA
    J Clin Invest 110:1643-50. 2002
    ..Thus, because it targets both the osteoclast and the osteoblast pathways, IL-7 is central to the altered bone turnover characteristic of estrogen deficiency...
  50. ncbi Thymopoiesis independent of common lymphoid progenitors
    David Allman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6160, USA
    Nat Immunol 4:168-74. 2003
    ..Thymic ETPs were not interleukin 7 (IL-7)-responsive and generated B lineage progeny with delayed kinetics, whereas BM CLPs were IL-7-responsive ..
  51. ncbi Transient IL-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements
    Dipanjan Chowdhury
    Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Immunity 18:229-41. 2003
    ..Thus, transient signals mediate V(H) gene activation and inactivation during development...
  52. ncbi The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3819-27. 2003
    ..hermsii. Together these results support the model that B1b cells generate the T-independent IgM required for the control and resolution of relapsing fever borreliosis...
  53. ncbi Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells
    Benedict Seddon
    Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Immunol 4:680-6. 2003
    ..We have shown here that interleukin 7 (IL-7) was an important survival factor for CD4 memory T cells that together with T cell receptor (TCR) ..
  54. ncbi A dose effect of IL-7 on thymocyte development
    Nahed El Kassar
    Experimental Immunology Branch, National Institutes of Health, 10 Center Drive, Bldg 10 Rm 4B36, Bethesda, MD 20892 1360, USA
    Blood 104:1419-27. 2004
    ..These results show for the first time in vivo a dose effect of IL-7 on alphabeta T-cell development and have implications for IL-7 in the clinical setting...
  55. pmc IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory
    Derek C Lenz
    Departments of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:9357-62. 2004
    ..We propose that homeostatic control of antiviral CD4(+) and CD8(+) T cell memory is fundamentally similar and characterized by quantitative, rather than qualitative, differences...
  56. ncbi Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors
    Roberto Baccala
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 174:4606-12. 2005
    ..Thus, gamma delta T cell homeostasis is maintained by trophic cytokines commonly used by other types of lymphoid cells, as well as by additional, as yet unidentified, gamma delta-specific factors...
  57. pmc IL-7 promotes T cell proliferation through destabilization of p27Kip1
    Wen Qing Li
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health NIH, Frederick, MD 21702, USA
    J Exp Med 203:573-82. 2006
    ..Hence, IL-7 maintains T cell proliferation through a novel pathway of p27Kip1 regulation...
  58. ncbi Do CD8 effector cells need IL-7R expression to become resting memory cells?
    Eva Buentke
    Division of Immune Cell Biology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Blood 108:1949-56. 2006
    ....
  59. ncbi Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7
    Regis Peffault De Latour
    Unité INSERM U 668, Unité du Développement des Lymphocytes, Institut Pasteur, Paris, France
    Blood 108:2300-6. 2006
    ..It also highlights the potential of the regulatory Foxp3-expressing CD4+CD25- T-cell population to restore a functional CD4+CD25+ T-cell compartment through an IL-7-independent pathway...
  60. ncbi A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, Institut National de la Santé et de la Recherche Médicale U668, Institut Pasteur, Paris F 75724, France
    Nat Immunol 7:1217-24. 2006
    ..NK cells repopulated peripheral lymphoid organs, and their homeostasis was strictly dependent on GATA-3 and interleukin 7. The CD127+ NK cells had a distinct phenotype (CD11b(lo) CD16- CD69(hi) Ly49(lo)) and unusual functional ..
  61. ncbi IL-7 Is essential for the development and the persistence of chronic colitis
    Teruji Totsuka
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 178:4737-48. 2007
    ....
  62. ncbi 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
    Jung Hyun Park
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 8:1049-59. 2007
    ..Coreceptor tuning' results from interplay between cytokine and TCR signals, such that signals from interleukin 7 and other common gamma-chain cytokines transcriptionally increase CD8 expression and thereby promote TCR ..
  63. ncbi IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia
    Onur Boyman
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 180:7265-75. 2008
    ..Finally, IL-7/mAb complexes were able to enhance the magnitude of the primary response of Ag-specific naive CD8(+) cells. The strong stimulatory activity of IL-7/mAb complexes could be useful for treatment of immunodeficiency and cancer...
  64. doi Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter
    Daniela Salopek
    Department of Oncology and Nuclear Medicine, Sisters of Mercy University Hospital, Zagreb, Croatia
    Immunol Lett 121:134-9. 2008
    ....
  65. pmc Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells
    Martin Guimond
    Pediatric Oncology Branch, National Cancer Institute, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 10:149-57. 2009
    b>Interleukin 7 (IL-7) and T cell antigen receptor signals have been proposed to be the main drivers of homeostatic T cell proliferation...
  66. pmc Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival
    Wen Qing Li
    Section of Cytokines and Immunity, National Cancer Institute, Frederick, MD 21702 1201, USA
    Mol Cell Biol 30:590-600. 2010
    ..Our findings suggest that the maintenance of peripheral T cells by IL-7 occurs partly through inhibition of Bim activity at the posttranslational level...
  67. pmc T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis
    Jae Ho Cho
    Immunology and Inflammation Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Immunity 32:214-26. 2010
    ..Thus, TCR contact with antigen upregulates GM1 and amplifies responsiveness of naive CD8(+) T cells to IL-2, thereby making the cells highly sensitive to exogenous IL-2 from CD4(+) T helper cells...
  68. pmc IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis
    Jacqueline Unsinger
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 184:3768-79. 2010
    ..If additional animal studies support its efficacy in sepsis and if current clinical trials continue to confirm its safety in diverse settings, rhIL-7 should be strongly considered for clinical trials in sepsis...
  69. pmc Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes
    Cedric Vonarbourg
    IMMH, Institute of Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
    Immunity 33:736-51. 2010
    ..Our data also define a previously unappreciated role of RORγt⁻ NKR-LTi cells for the onset or maintenance of inflammatory bowel diseases...
  70. doi In vivo administration of the recombinant IL-7/hepatocyte growth factor β hybrid cytokine efficiently restores thymopoiesis and naive T cell generation in lethally irradiated mice after syngeneic bone marrow transplantation
    Jingjun Jin
    Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 186:1915-22. 2011
    ..It also supports the maturation and homeostatic expansion of peripheral T cells. Consequently, the in vivo administration of rIL-7/HGFβ may offer a new approach to preventing and/or correcting post-BMT T cell immune deficiency...
  71. pmc An in vivo IL-7 requirement for peripheral Foxp3+ regulatory T cell homeostasis
    Grace Y Kim
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:5859-66. 2012
    ....
  72. ncbi Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR
    M C Haks
    Division of Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121, Amsterdam, CX, 1066, The Netherlands
    Semin Immunol 11:23-37. 1999
    ....
  73. ncbi The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor
    T Egawa
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, 840, Murodo cho, Izumi, 594 1101, Osaka, Japan
    Immunity 15:323-34. 2001
    ..Moreover, SDF-1 exhibited specific biologic activities on the earliest B cell precursors. SDF-1 provides the first example of a cytokine responsible for the earliest B lineage stages...
  74. pmc Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A
    Christopher S Seet
    Department of Pathology, University of Chicago, 5841 S Maryland Avenue, MC 1089, Chicago, IL 60637, USA
    J Exp Med 199:1689-700. 2004
    ..Remarkably, however, we find that E2A proteins are required for interleukin 7-dependent proliferation due, in part, to a role for E2A in optimal expression of N-myc...
  75. ncbi Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells
    Jo Harnaha
    Department of Pathology, University of Pittsburgh School of Medicine, Diabetes Institute, Rangos Research Center, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA
    Diabetes 55:158-70. 2006
    ....
  76. doi Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells
    Sandrine Schmutz
    Division of Developmental Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland
    J Immunol 183:2217-21. 2009
    ..Our observations demonstrate that adult CD4(+)lineage(-) cells are LTi cells and that the availability of IL-7 determines the size of the adult LTi cell pool...
  77. ncbi IL-7 transgenic mice: analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro
    E Mertsching
    LGME du CNRS, U184 INSERM, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    Int Immunol 7:401-14. 1995
    ..We conclude that IL-7 is probably not an important differentiation factor for immature mouse thymocytes...
  78. ncbi Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout mice
    S Candeias
    SAIC, NCI FCRDC, Frederick, MD 21702 1201, USA
    Immunol Lett 57:9-14. 1997
    ..These findings indicate that one or both of the two known ligands of IL-7R, IL-7 and thymic stromal lymphopoietin (TSLP) serves as an extrinsic signal to specifically rearrange the TCR gamma locus...
  79. ncbi Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age
    R P Stephan
    Department of Cell Biology, Loyola University Chicago, Maywood, IL
    Blood 91:75-88. 1998
    ..Therefore, we conclude that the age-related decrease in the function of bone marrow stromal cells is related to the impaired release of IL-7...
  80. ncbi Bax deficiency partially corrects interleukin-7 receptor alpha deficiency
    Annette R Khaled
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, MD 21702, USA
    Immunity 17:561-73. 2002
    ..The BH3 only proteins, Bad and Bim, were also part of the death pathway repressed by IL-7. Thus, in young mice, Bax emerges as an essential protein in the death pathway induced by IL-7 deficiency...
  81. pmc IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells
    Gianluca Toraldo
    Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:125-30. 2003
    ..Importantly, T cell adoptive transfer into nude mice restored IL-7-induced bone loss, and RANKL and TNF-alpha secretion, demonstrating that T cells are essential mediators of IL-7-induced bone loss in vivo...
  82. ncbi Autoantibodies inhibit interleukin-7-mediated proliferation and are associated with the age-dependent loss of pre-B cells in autoimmune New Zealand Black Mice
    M S Merchant
    Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101, USA
    Blood 87:3289-96. 1996
    ..The production of such autoantibodies may interfere with B cell development in aging NZB mice by preventing IL-7-mediated proliferation...
  83. pmc Several different cell surface molecules control negative selection of medullary thymocytes
    H Kishimoto
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    J Exp Med 190:65-73. 1999
    ..The results suggest that efficient negative selection requires the combined functions of at least four cell surface molecules: CD28, CD5, CD43, and Fas...
  84. ncbi Pre-pro-B cell growth-stimulating factor (PPBSF) upregulates IL-7Ralpha chain expression and enables pro-B cells to respond to monomeric IL-7
    Chiju Wei
    Department of Pathology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030 3105, USA
    J Interferon Cytokine Res 22:823-32. 2002
    ....
  85. ncbi Distinct requirements for IL-7 in development of TCR gamma delta cells during fetal and adult life
    Karen Laky
    Department of Medicine, Division of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 170:4087-94. 2003
    ..BrdU incorporation studies indicated that although IL-7 was not required for TCRgammadelta cell proliferation, it was required to prolong the life span of mature TCRgammadelta cells...
  86. ncbi Interleukin-7 influences osteoclast function in vivo but is not a critical factor in ovariectomy-induced bone loss
    Sun Kyeong Lee
    Division of Endocrinology, Department of Medicine, University of Connecticut Health Center, Farmington, 06030, USA
    J Bone Miner Res 21:695-702. 2006
    ..In this study we show that IL-7-deficient mice have increased OC and decreased trabecular bone volume compared with WT mice but mimic WT mice in the amount of trabecular but not cortical bone lost after ovariectomy...
  87. ncbi Sjögren's syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus
    C Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Scand J Immunol 64:295-307. 2006
    ..These data suggest SjS-like disease in the NOD mouse shows gender-specific regulation determined by autosomal genes...
  88. ncbi An IL-7 splicing-defect lymphopenia mouse model revealed by genome-wide mutagenesis
    Hong Wen Huang
    Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan
    J Biomed Sci 14:169-81. 2007
    ..Such mutation resulted in skipping of exon 3 and production of an internally truncated IL-7 (DeltaE3-IL7)...
  89. ncbi Mesenchymal cells are required for functional development of thymic epithelial cells
    Manami Itoi
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Int Immunol 19:953-64. 2007
    ..In addition, our data suggest that mesenchymal cells are required to create the thymic microenvironment and to maintain epithelial architecture and function...
  90. doi Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development
    Stephane Chappaz
    Division of Developmental Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland
    J Immunol 185:3514-9. 2010
    ..To determine the relative significance of Il7 and Kit signaling in LTi cell homeostasis and PP and LN development, we have analyzed mice deficient for Kit (Kit(W/..
  91. ncbi Interleukin 7: effects on early events in lymphopoiesis
    C S Henney
    Immunol Today 10:170-3. 1989
    ..In this review, Christopher Henney describes the isolation and characterization of one such factor-IL-7-and its effect on early B- and T-cell development...
  92. ncbi Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene
    K Muegge
    Biological Carcinogenesis and Development Program, Program Resources Inc DynCorp, National Cancer Institute Frederick Cancer Research and Development Center, MD 21702
    Science 261:93-5. 1993
    ..These data implicate IL-7, a cytokine that is abundantly expressed in embryonic thymus, in driving gene rearrangement during early T cell development...
  93. pmc Novel role of interleukin 7 in myelopoiesis: stimulation of primitive murine hematopoietic progenitor cells
    F W Jacobsen
    Department of Immunology, Norwegian Radium Hospital, Montebello, Oslo, Norway
    J Exp Med 178:1777-82. 1993
    b>Interleukin 7 (IL-7) has been demonstrated to be an important regulator of the growth of B and T cell precursors as well as mature T cells, whereas IL-7 has been reported to have no direct myeloproliferative effects...
  94. pmc Transgenic expression of interleukin 7 restores T cell populations in nude mice
    B E Rich
    Department of Genetics, Harvard Medical School, Boston, Massachusetts
    J Exp Med 181:1223-8. 1995
    ..b>Interleukin 7 (IL-7), a lymphokine that is normally expressed in the thymus and has been implicated in T cell maturation, ..
  95. ncbi Effect of IL-7 treatment on Leishmania major-infected BALB.Xid mice: enhanced lymphopoiesis with sustained lack of B1 cells and clinical aggravation of disease
    A Hoerauf
    Institute of Clinical Microbiology and Immunology, University of Erlangen Nurnberg, Germany
    Int Immunol 7:1879-84. 1995
    ..In conclusion, selective up-regulation of B2 cells by IL-7 in the absence of B1 cells is associated with disease aggravation in L. major-infected BALB.Xid mice...
  96. ncbi Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13
    P Han
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genomics 48:275-6. 1998
  97. ncbi Interaction of abl and raf with IL-7 signaling pathway and transformation of pre-B cells from resistant mice
    D M Hilbert
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncogene 17:2125-35. 1998
    ....
  98. ncbi Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase
    L Bi
    Genetic Diseases Research Branch, NHGRI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:10963-8. 1999
    ..A proliferative defect is supported by the observation that fibroblasts from Pik3cadel/del embryos fail to replicate in Dulbecco's modified Eagle's medium and fetal calf serum, even with supplemental growth factors...
  99. ncbi The emerging role of IL-15 in NK-cell development
    C C Liu
    Division of Rheumatology and Clinical Immunology, Dept of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260
    Immunol Today 21:113-6. 2000
  100. pmc Enterocyte expression of interleukin 7 induces development of gammadelta T cells and Peyer's patches
    K Laky
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 1310, USA
    J Exp Med 191:1569-80. 2000
    ..binding protein (iFABP) promoter, we reinstated expression of IL-7 to mature enterocytes of IL-7(-/)- mice (iFABP-IL7). In iFABP-IL7 mice, TCR-gammadelta IELs were restored, as were cryptopatches and Peyer's patches...
  101. ncbi Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11
    Hui Chen Hsu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
    Mech Ageing Dev 123:1145-58. 2002
    ..6 cM, and 18.0 cM, respectively. Our results suggest that several genetic loci regulate the intra-thymic T-cell maturation process and play an important role in determining age-related decline in thymic T-cell development...

Research Grants7

  1. FUNCTIONAL HETROGENEITY OF NK CELLS DURING DEVELOPMENT
    HECTOR AGUILA; Fiscal Year: 2003
    ..2. To define the phenotype and functional heterogeneity of the NK cell compartment. 3. To establish methods to grow and propagate clonal cell lines of murine NK cells. ..
  2. Ab5 Toxins Nasal Adjuvant Target the Olfactory Bulbs/CNS
    Kohtaro Fujihashi; Fiscal Year: 2004
    ..These proposed studies will provide essential new information to determine potential side effects of CT-B derivatives as nasal adjuvants, and point to ways where these toxic effects can be avoided. ..
  3. CELLULAR AND MOLECULAR MECHANISMS FOR MUCOSAL IMMUNITY
    Kohtaro Fujihashi; Fiscal Year: 2005
    ..The seminal findings which have emanated from this grant effort since 1982 will again remain focused on the cellular and molecular events required for induction of mucosal immunity or oral tolerance in the GI tract. ..
  4. Anti-Tumor Autoimmunity by lymphopenia T cell Expansion
    Roberto Baccala; Fiscal Year: 2008
    ..The results will define the role of homeostatic T cell proliferation in tumor autoimmunity, and provide new approaches to the treatment of cancer. [unreadable] [unreadable]..
  5. Epigenetic control of hematopoietic stem cells
    Christa Muller Sieburg; Fiscal Year: 2007
    ..Relevance: Data from the proposed studies may provide better ways to treat leukopenia and may help in the design of approaches to selectively eradicate leukemic stem cells. ..
  6. ADENOVIRUS FLT3 LIGAND INDUCES NALT DCs FOR SALIVARY GLAND S-lgA Ab RESPONSES
    Kohtaro Fujihashi; Fiscal Year: 2010
    ..4) Determination of the precise mechanism for cross-talk between Ad-FL-induced salivary DCs, B-1 B cells and yS T cells for salivary S-lgA Ab responses. ..
  7. NALT-BASED ADJUVANTS FOR MUCOSAL IMMUNITY IN AGING
    Kohtaro Fujihashi; Fiscal Year: 2010
    ....