Inpp5b

Summary

Gene Symbol: Inpp5b
Description: inositol polyphosphate-5-phosphatase B
Alias: 5PTase, AW260155, INPP5P, type II inositol 1,4,5-trisphosphate 5-phosphatase, inositol polyphosphate-5-phosphatase, 75 kDa, phosphoinositide 5-phosphatase
Species: mouse

Top Publications

  1. ncbi Distinct membrane and cytosolic forms of inositol polyphosphate 5-phosphatase II. Efficient membrane localization requires two discrete domains
    M Matzaris
    Monash University Department of Medicine, Box Hill Hospital, Nelson Road, Box Hill, Melbourne, Australia 3128
    J Biol Chem 273:8256-67. 1998
  2. pmc Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice
    P A Jänne
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Clin Invest 101:2042-53. 1998
  3. ncbi Sertoli cell vacuolization and abnormal germ cell adhesion in mice deficient in an inositol polyphosphate 5-phosphatase
    Elina Hellsten
    Genetic Diseases Research Branch, National Human Genome Research Institute, Veterinary Resources Program, Office of Director, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA
    Biol Reprod 66:1522-30. 2002
  4. pmc X-inactivation analysis of embryonic lethality in Ocrl wt/-; Inpp5b-/- mice
    David J Bernard
    Inborn Errors and Cell Biology, Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mamm Genome 21:186-94. 2010
  5. ncbi Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b
    E Hellsten
    Genetic Diseases Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Dev Biol 240:641-53. 2001
  6. pmc Mammalian inositol polyphosphate 5-phosphatase II can compensate for the absence of all three yeast Sac1-like-domain-containing 5-phosphatases
    C J O'Malley
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia
    Biochem J 355:805-17. 2001
  7. doi The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease
    Lisa M Ooms
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Biochem J 419:29-49. 2009
  8. pmc Mouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy
    Susan P Bothwell
    University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Am Soc Nephrol 22:443-8. 2011
  9. ncbi Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia
    F Vidal
    U385 INSERM, Faculte de Medecine, Nice, France
    Nat Genet 10:229-34. 1995
  10. ncbi Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34
    P A Jänne
    Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia
    Cytogenet Cell Genet 66:164-6. 1994

Scientific Experts

  • Y Y Maeda
  • Susan P Bothwell
  • Robert L Nussbaum
  • David J Bernard
  • P A Jänne
  • Matthew R Marcello
  • Lisa M Ooms
  • Kristy A Horan
  • Christina A Mitchell
  • Anne M Kong
  • C J O'Malley
  • R L Nussbaum
  • Elina Hellsten
  • E Hellsten
  • Emily Chan
  • Isa M Bernardini
  • William A Gahl
  • Yien Ming Kuo
  • Janice P Evans
  • Leslie W Farber
  • Adam Hoagland
  • Rajendra Gurung
  • Dharini S Kethesparan
  • Gillian Seaton
  • C A Mitchell
  • Parvin Rahman
  • Charles G Bailey
  • Luke J Collyer
  • Assia Shisheva
  • M Matzaris
  • Tony Rowe
  • John E J Rasko
  • Meredith J Layton
  • Harshal H Nandurkar
  • A Kuroiwa
  • Absorn Sriratana
  • Michael Eckhaus
  • Sharon F Suchy
  • Jennie W Owens
  • J Sambrook
  • B K McColl
  • J P Evans
  • D J Bernard
  • A M Kong
  • S L Ellis
  • A P Wijayaratnam
  • F Vidal
  • A Nagabukuro
  • A Wynshaw-Boris
  • H Westphal
  • M Ono
  • P I Bird
  • J Crawley
  • M Inui
  • Y Matsuda
  • A Grinberg
  • S F Suchy
  • Y Yamashita
  • C J Speed
  • D Bernard
  • M Macdonald
  • T Takai
  • T Yuasa
  • A Badger
  • M F Seldin
  • C Miquel
  • P A Martin-Deleon
  • J P Ortonne
  • G Meneguzzi
  • D Aberdam
  • J M Rochelle
  • L Pulkkinen
  • D Stambolian
  • A M Christiano
  • J Uitto
  • N C Dracopoli
  • A S Dutra
  • J M Puck
  • L R Charnas

Detail Information

Publications16

  1. ncbi Distinct membrane and cytosolic forms of inositol polyphosphate 5-phosphatase II. Efficient membrane localization requires two discrete domains
    M Matzaris
    Monash University Department of Medicine, Box Hill Hospital, Nelson Road, Box Hill, Melbourne, Australia 3128
    J Biol Chem 273:8256-67. 1998
    ..This allows differential distribution of the 5-phosphatase II activity between the membrane and cytosol of the cell and thereby may regulate enzyme access to phosphoinositide-derived signaling molecules...
  2. pmc Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice
    P A Jänne
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Clin Invest 101:2042-53. 1998
    ..We hypothesized that Ocrl1 deficiency is complemented in mice by inositol polyphosphate 5-phosphatase (Inpp5b), an autosomal gene that encodes a phosphatidylinositol bisphosphate 5-phosphatase highly homologous to Ocrl1...
  3. ncbi Sertoli cell vacuolization and abnormal germ cell adhesion in mice deficient in an inositol polyphosphate 5-phosphatase
    Elina Hellsten
    Genetic Diseases Research Branch, National Human Genome Research Institute, Veterinary Resources Program, Office of Director, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA
    Biol Reprod 66:1522-30. 2002
    ..junctions and stain positive for N-cadherin and beta-catenin in the Sertoli cell cytosol of mice deficient in Inpp5b, an inositol polyphosphate 5-phosphatase...
  4. pmc X-inactivation analysis of embryonic lethality in Ocrl wt/-; Inpp5b-/- mice
    David J Bernard
    Inborn Errors and Cell Biology, Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mamm Genome 21:186-94. 2010
    ..Targeted disruption of its closest paralog, Inpp5b, causes male infertility in the 129S6 background. Mice with disruptions of both genes are lost in utero prior to 9...
  5. ncbi Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b
    E Hellsten
    Genetic Diseases Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Dev Biol 240:641-53. 2001
    b>Inpp5b is an ubiquitously expressed type II inositol polyphosphate 5-phosphatase. We have disrupted the Inpp5b gene in mice and found that homozygous mutant males are infertile. Here we examine the causes for the infertility in detail...
  6. pmc Mammalian inositol polyphosphate 5-phosphatase II can compensate for the absence of all three yeast Sac1-like-domain-containing 5-phosphatases
    C J O'Malley
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia
    Biochem J 355:805-17. 2001
    ..Collectively, these studies demonstrate the functional and cellular consequences of PtdIns(4,5)P(2) accumulation and the evolutionary conservation of function between mammalian and yeast PtdIns(4,5)P(2) 5-phosphatases...
  7. doi The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease
    Lisa M Ooms
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Biochem J 419:29-49. 2009
    ..inositol phosphatase] 2, SKIP (skeletal muscle- and kidney-enriched inositol phosphatase) and 72-5ptase (72 kDa 5-ptase)/Type IV/Inpp5e (inositol polyphosphate 5-phosphatase E) are implicated in negatively regulating ..
  8. pmc Mouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy
    Susan P Bothwell
    University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Am Soc Nephrol 22:443-8. 2011
    ..b>Inpp5b and INPP5B, paralogous autosomal genes that encode another type II phosphoinositide 5-phosphatase in mice and ..
  9. ncbi Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia
    F Vidal
    U385 INSERM, Faculte de Medecine, Nice, France
    Nat Genet 10:229-34. 1995
    ..The maternal mutation occurs in a donor splice site, and results in in-frame exon skipping involving the cytoplasmic domain of the polypeptide. Our results implicate mutations in the beta 4 integrin gene in some forms of PA-JEB...
  10. ncbi Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34
    P A Jänne
    Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia
    Cytogenet Cell Genet 66:164-6. 1994
    ..To further characterize these enzymatic forms, we have mapped the gene (INPP5B) coding for the 75-kDa type II enzyme...
  11. ncbi Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens
    P A Jänne
    Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia, USA
    Genomics 28:280-5. 1995
    ..determined the chromosomal localization of the murine gene encoding a 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b)...
  12. ncbi Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene
    A Kuroiwa
    Laboratory of Animal Genetics, School of Agricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 01, Japan
    J Biol Chem 273:1070-4. 1998
    ..The gene pair was shown to locate in the B4 band of mouse chromosome 10. In this region, no conserved linkage homology to human chromosome 19, where the genes for killer cell inhibitory receptors are found, has been identified...
  13. ncbi Two interactive genes responsible for a new inherited cataract (RCT) in the mouse
    Y Y Maeda
    The Tokyo Metropolitan Institute of Medical Science Rinshoken, Dept of Laboratory Animal Science, Japan
    Mamm Genome 12:278-83. 2001
    ..The rct locus essential for the onset of the cataract was tightly linked to D4Mit278 on Chromosome (Chr) 4 with no recombination. The mrct locus was closely linked to D5Mit239 (chi2 = 66.3, P << 0.00001) on Chr 5...
  14. pmc Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane
    Anne M Kong
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Mol Cell Biol 26:6065-81. 2006
    ..ectopic expression of wild-type, but not catalytically inactive 72-kDa inositol polyphosphate 5-phosphatase (72-5ptase), generated PtdIns(3)P at the plasma membrane...
  15. pmc Multivariate analysis of male reproductive function in Inpp5b-/- mice reveals heterogeneity in defects in fertility, sperm-egg membrane interaction and proteolytic cleavage of sperm ADAMs
    Matthew R Marcello
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Mol Hum Reprod 16:492-505. 2010
    Past work indicated that sperm from mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b have reduced ability to fertilize eggs in vitro and reduced epididymal proteolytic processing of the sperm protein A Disintegrin and A ..
  16. pmc Species-specific difference in expression and splice-site choice in Inpp5b, an inositol polyphosphate 5-phosphatase paralogous to the enzyme deficient in Lowe Syndrome
    Susan P Bothwell
    Department of Medicine, University of California San Francisco School of Medicine, 513 Parnassus Avenue Hse901E, UCSF Box 0794, San Francisco, CA 94143, USA
    Mamm Genome 21:458-66. 2010
    ..We therefore turned our attention to Inpp5b, another type II PtdIns4,5P(2) 5-phosphatase encoded by Inpp5b in mice and INPP5B in humans, as potential ..