Irf2

Summary

Gene Symbol: Irf2
Description: interferon regulatory factor 2
Alias: 9830146E22Rik, AI646973, Irf-2, interferon regulatory factor 2
Species: mouse

Top Publications

  1. pmc An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes
    P H Driggers
    Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 87:3743-7. 1990
  2. ncbi Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes
    H Harada
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Cell 58:729-39. 1989
  3. pmc Differential expression of interferon regulatory factor 1 (IRF-1), IRF-2, and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages
    S A Barber
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4788
    Infect Immun 63:601-8. 1995
  4. ncbi Interferon regulatory factors: the next generation
    Y Mamane
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada
    Gene 237:1-14. 1999
  5. ncbi Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
    T Matsuyama
    Amgen Institute, University of Toronto, Ontario, Canada
    Cell 75:83-97. 1993
  6. ncbi IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice
    C A Salkowski
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 163:1529-36. 1999
  7. ncbi Differential dysregulation of nitric oxide production in macrophages with targeted disruptions in IFN regulatory factor-1 and -2 genes
    C A Salkowski
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 156:3107-10. 1996
  8. pmc Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis
    T Fehr
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Exp Med 185:921-31. 1997
  9. ncbi Cell cycle regulation of histone H4 gene transcription requires the oncogenic factor IRF-2
    P S Vaughan
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
    J Biol Chem 273:194-9. 1998
  10. ncbi Cytokine gene regulation: regulatory cis-elements and DNA binding factors involved in the interferon system
    N Tanaka
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Adv Immunol 52:263-81. 1992

Scientific Experts

  • Atsuko Masumi
  • Shinsuke Taki
  • Ali A Ashkar
  • Hirosato Mashima
  • J E Gudjonsson
  • Taku Sato
  • Shigeaki Hida
  • Kenya Honda
  • Natalia Cuesta
  • Tatsuaki Mizutani
  • Krishna Prakash
  • T Taniguchi
  • Yu Jiao Cai
  • C A Salkowski
  • Eri Ichikawa
  • Tsuyoshi Notake
  • James Blackburn
  • Kento Minamino
  • John R Klune
  • Toshio Suda
  • Toshiaki Ohteki
  • Stefanie N Vogel
  • Hideki Hayashi
  • Eun Joo Kim
  • Mari Liljeroos
  • Kazuhiko Takahara
  • Ok Ju Sul
  • Kayo Inaba
  • Fuyuko Arakura
  • Tadatsugu Taniguchi
  • S N Vogel
  • Myung Chul Chung
  • Tracy C Kuo
  • Cindy A Salkowski
  • Somnath Mukherjee
  • Jinkyung Ko
  • Rong Lin Xie
  • Pardeep Kumar
  • P C Rath
  • Shuling Zhang
  • Toya Ohashi
  • Yang Yang
  • Takahiro Fukuda
  • Hiroshi Kobayashi
  • Hua Yang
  • Wen Sheng Wang
  • Satoshi Yotsumoto
  • Li hua Sun
  • Yohta Shimada
  • Takashi Higuchi
  • Daniel H Teitelbaum
  • Mahoko Ikeda
  • H Harada
  • Ruth Schmidt-Ullrich
  • Takumi Adachi
  • Brian C Schutte
  • Katsushige Kawasaki
  • Atsunori Nakao
  • Hideki Sanjo
  • Koji Nagaoka
  • Rajeev Dhupar
  • Tomonori Iyoda
  • Allan Tsung
  • Akira Kinoshita
  • H Xi
  • Gary Nace
  • Yoko Otsuka-Tanaka
  • Shinya Ueki
  • Ryan B Rountree
  • David A Geller
  • Atsushi Ohazama
  • John Evankovich
  • Noriko Murase
  • Shoko Kimura
  • Bigang Liu
  • Maiko Kawasaki
  • Shin Ichi Miyagawa
  • Yinling Hu
  • Jon Cardinal
  • Walter Birchmeier
  • Nigel L Hammond
  • Shin Horisawa
  • Paul T Sharpe
  • Michael J Dixon
  • Koon Jiew Chua
  • Yuhua Ma
  • Yoshinao Kubo
  • Tohru Kimura
  • Takashi Suematsu
  • Ichiro Katayama

Detail Information

Publications51

  1. pmc An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes
    P H Driggers
    Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 87:3743-7. 1990
    ..The presence of multiple factors that bind common IFN response motifs may partly account for the complexity and diversity of IFN action as well as IFN-regulated gene expression...
  2. ncbi Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes
    H Harada
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Cell 58:729-39. 1989
    ..Our results suggest that transcription of the IFN and IFN-inducible genes is regulated by two similar trans-acting factors that apparently compete for the same cis-acting recognition sequences, but which have opposite effects...
  3. pmc Differential expression of interferon regulatory factor 1 (IRF-1), IRF-2, and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages
    S A Barber
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4788
    Infect Immun 63:601-8. 1995
    ..Thus, the IRFs may represent yet an additional molecular pathway in the complex response to LPS...
  4. ncbi Interferon regulatory factors: the next generation
    Y Mamane
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada
    Gene 237:1-14. 1999
    ..The aim of this review is to provide an update on the novel discoveries in the area of IRF transcription factors and the important roles of the new generation of IRFs--particularly IRF-3, IRF-4 and IRF-7...
  5. ncbi Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
    T Matsuyama
    Amgen Institute, University of Toronto, Ontario, Canada
    Cell 75:83-97. 1993
    ..IRF-2-deficient mice exhibited bone marrow suppression of hematopoiesis and B lymphopoiesis and mortality following lymphocytic choriomeningitis virus infection...
  6. ncbi IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice
    C A Salkowski
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 163:1529-36. 1999
    ..These results indicate that both IRF-1 and IRF-2 are critical transcription factors in the regulation of macrophage IL-12 and consequently IFN-gamma production...
  7. ncbi Differential dysregulation of nitric oxide production in macrophages with targeted disruptions in IFN regulatory factor-1 and -2 genes
    C A Salkowski
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 156:3107-10. 1996
    ..synthase mRNA in response to IFN-gamma and LPS. These results indicate that IRF-1 and IRF-2 differ in their mechanism of NO. regulation and that IRF-2 regulates inducible NO. synthase post-transcriptionally...
  8. pmc Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis
    T Fehr
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Exp Med 185:921-31. 1997
    ..ICSBP-/- and to a lesser degree also IRF2-/- mice were highly susceptible to Listeria infection...
  9. ncbi Cell cycle regulation of histone H4 gene transcription requires the oncogenic factor IRF-2
    P S Vaughan
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
    J Biol Chem 273:194-9. 1998
    ..We have previously shown that the transcription factor interferon regulatory factor 2 (IRF-2) can activate histone H4 gene expression...
  10. ncbi Cytokine gene regulation: regulatory cis-elements and DNA binding factors involved in the interferon system
    N Tanaka
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Adv Immunol 52:263-81. 1992
  11. doi Chimeric murine interferon regulatory factor-2 (IRF-2) binds to IRF-E (IRF binding element), VREβ (virus response element) but not to VREα1
    Krishna Prakash
    Recombinant DNA Technology Laboratory, Centre for Biological Science, Central University of Bihar, Patna, India School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Cell Biochem Funct 32:630-6. 2014
    ..This study is first of its kind and paves the way to understand the differential DNA binding and molecular mechanism of DNA binding activity of the IRF-2 molecule, which is crucial for its function(s)...
  12. pmc Up-regulation of intestinal epithelial cell derived IL-7 expression by keratinocyte growth factor through STAT1/IRF-1, IRF-2 pathway
    Yu Jiao Cai
    Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    PLoS ONE 8:e58647. 2013
    ..This study was to further investigate the molecular mechanism involved in the regulation of IL-7 expression by KGF in the intestine...
  13. pmc Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury
    John R Klune
    Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Gastrointest Liver Physiol 303:G666-73. 2012
    ..No strategies to mitigate IRF1-mediated liver damage exist. IRF2 is a structurally similar endogenous protein that competes with IRF1 for DNA binding sites in IRF-responsive target ..
  14. doi Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors
    Tsuyoshi Notake
    Department of Immunology and Infectious Diseases, Shinshu University Graduate School of Medicine, Matsumoto 390 8621, Japan
    J Immunol 188:4838-45. 2012
    ..The influence of IRF-2 deficiency on Ly49(+) memory phenotype T cells observed in this study suggested a unique transcriptional program for this T cell population among other NKR(+) T and memory phenotype T cells...
  15. doi The role of Irf6 in tooth epithelial invagination
    James Blackburn
    Department of Craniofacial Development and Comprehensive Biomedical Research Centre, Dental Institute, King s College London, UK
    Dev Biol 365:61-70. 2012
    ..Irf6 thus also plays a critical role in regulating epithelial invagination. In addition, we also found that canonical Wnt signaling is upregulated in evaginated incisor epithelium of both Ikkα and Irf6 mutant embryos...
  16. doi Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder
    Taku Sato
    Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 5810, Japan
    Blood 121:3267-73. 2013
    ..active type I IFN signaling in HSC recipients was further demonstrated using mice lacking IFN regulatory factor 2 (IRF2), a transcriptional suppressor of type I IFN signaling...
  17. doi IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms
    Kento Minamino
    Laboratory of Immunology, Department of Animal Development and Physiology, Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University, Japan
    Int Immunol 24:573-81. 2012
    ..These results revealed a multi-faceted role of IRF-2 in the function of B cells, particularly B2 cells, through regulating proliferation in an IFNAR-dependent manner and antibody production via up-regulation of Blimp-1...
  18. pmc Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription
    Hideki Hayashi
    Division of Cytokine Signaling, Department of Molecular Biology, Nagasaki University Graduate School of Biomedical Science, Nagasaki 852 8523, Japan
    Proc Natl Acad Sci U S A 108:18766-71. 2011
    Mice deficient for interferon regulatory factor (Irf)2 (Irf2(-/-) mice) exhibit immunological abnormalities and cannot survive lymphocytic choriomeningitis virus infection...
  19. doi Interferon regulatory factor-2 induces megakaryopoiesis in mouse bone marrow hematopoietic cells
    Atsuko Masumi
    Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan
    FEBS Lett 583:3493-500. 2009
    ..The number of CD41-positive bone marrow cells increased in mice injected with IRF-2-expressing bone marrow cells. These findings suggest that IRF-2 plays an important role in megakaryopoiesis in inflammatory states...
  20. ncbi Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance
    Shigeaki Hida
    Department of Immunology and Infectious Diseases, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Blood 106:2011-7. 2005
    ..Here we show that naive mice lacking the transcription factor, interferon regulatory factor 2 (IRF-2), exhibited signal transducer and activator of transcription 6 (Stat6)-independent expansion of ..
  21. ncbi IFN regulatory factor-2 regulates macrophage apoptosis through a STAT1/3- and caspase-1-dependent mechanism
    Natalia Cuesta
    Department of Microbiology and Immunology, University of Maryland School of Medicine, 600 West Baltimore Street, Baltimore, MD 21201, USA
    J Immunol 178:3602-11. 2007
    ..Collectively, these data support the hypothesis that IRF-2 acts as a transcriptional repressor of Casp1, and that the absence of IRF-2 renders macrophages more sensitive to apoptotic stimuli in a caspase-1-dependent process...
  22. ncbi Mouse models of psoriasis
    Johann E Gudjonsson
    Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Invest Dermatol 127:1292-308. 2007
    ..In this review, we describe various animal models, detail the immunologic and intracellular pathways that mediate these phenotypes and assess the utility of these models to better understand this disease...
  23. ncbi Genetic control directed toward spontaneous IFN-alpha/IFN-beta responses and downstream IFN-gamma expression influences the pathogenesis of a murine psoriasis-like skin disease
    Fuyuko Arakura
    Department of Immunology and Infectious Diseases, Graduate School of Medicine, Shinshu University, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Immunol 179:3249-57. 2007
    ....
  24. ncbi Regulation of the murine TR2/HVEM gene expression by IRF
    Ok Ju Sul
    Department of Biological Science and the Immunomodulation Research Center, University of Ulsan, San29 Mugeo Dong, Nam Gu, Ulsan 680 749, Republic of Korea
    Biochem Biophys Res Commun 367:277-83. 2008
    ..Transfection of IRF-2 expression plasmid and of dominant negative IRF-2 mutant further confirmed our results. Together, these data demonstrate that IRF-2 is involved in the regulation of TR2 expression in EL-4 T cells...
  25. doi Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling
    Tatsuaki Mizutani
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Exp Hematol 36:255-64. 2008
    ..type I interferon (IFN) is known to inhibit erythropoiesis, we studied mice deficient in the gene for interferon regulatory factor 2 (IRF2), which functions as a negative regulator of type I IFN signaling, in the context of ..
  26. doi Bacterial ligand of TLR2 signals Stat activation via induction of IRF1/2 and interferon-alpha production
    Mari Liljeroos
    Institute of Clinical Medicine, Division of Pediatrics, University of Oulu, Oulu, FIN 90014, Finland
    Cell Signal 20:1873-81. 2008
    ..Here, we studied the involvement of IRF1 and IRF2 in TLR2-mediated responses...
  27. doi Ubc9-mediated sumoylation leads to transcriptional repression of IRF-1
    Eun Joo Kim
    Department of Molecular Biology, Dankook University, Gyeonggi do 448 701, Republic of Korea
    Biochem Biophys Res Commun 377:952-6. 2008
    ..Taken together, these observations suggest that Ubc9 functions as a transcriptional repressor of IRF-1 by inducing sumoylation, and that this effect may be required for the physiological activity of IRF-1...
  28. doi Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion
    Taku Sato
    Department of Immunology, Akita University Graduate School of Medicine, Akita, Japan
    Nat Med 15:696-700. 2009
    ..induce proliferation and exhaustion in hematopoietic stem cells (HSCs) and that interferon regulatory factor-2 (IRF2), a transcriptional suppressor of type I IFN signaling5, 6, preserves the self-renewal and multilineage ..
  29. ncbi IFN regulatory factor-2 deficiency revealed a novel checkpoint critical for the generation of peripheral NK cells
    Shinsuke Taki
    Department of Immunology and Infectious Diseases, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    J Immunol 174:6005-12. 2005
    ..The differential peripheral and central NK cell deficiencies in IRF-2(-/-) mice thus revealed a novel late checkpoint for NK cell maturation, distinct from the early IL-15-dependent expansion stage...
  30. doi Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells
    Hirosato Mashima
    Department of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan
    Gastroenterology 141:1102-1113.e1-8. 2011
    Pancreatic acinar cells are used to study regulated exocytosis. We investigated the role of interferon regulatory factor-2 (IRF2) in exocytosis in pancreatic acinar cells.
  31. ncbi Differential constitutive expression of interferon genes in early mouse embryos
    E Riego
    Mammalian Cell Genetics Division, Centro de Ingenieria Genetica y Biotecnologia, Havana, Cuba
    Mol Reprod Dev 41:157-66. 1995
    ..Mu IFN-alpha A and a new Mu IFN-alpha species (Mu IFN-alpha 12) were isolated from (D-) P19 cells. The presence of constitutive IFN-alpha transcripts in early mouse embryos suggests a role for these molecules during embryogenesis...
  32. ncbi The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2
    M Horiuchi
    Division of Cardiovascular Medicine, Falk Cardiovascular Center, Stanford University School of Medicine, California 94305 5246, USA
    J Biol Chem 270:20225-30. 1995
    ..We speculate that these transcriptional factors influence cell growth in part by regulating AT2 receptor expression...
  33. ncbi Forced expression of the interferon regulatory factor 2 oncoprotein causes polyploidy and cell death in FDC-P1 myeloid hematopoietic progenitor cells
    Rong Lin Xie
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 62:2510-5. 2002
    ..Our data suggest that the IRF-2 oncoprotein regulates a critical cell cycle checkpoint that controls progression through G2 and mitosis in FDC-P1 hematopoietic progenitor cells...
  34. ncbi Interferon regulatory transcription factors are constitutively expressed and spatially regulated in the mouse lens
    W Li
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 210:44-55. 1999
    ....
  35. ncbi Characterization of the DNA binding domain of the mouse IRF-2 protein
    K Uegaki
    Institute for Protein Research, Osaka University, Japan
    Protein Eng 6:195-200. 1993
    ..These results showed that this peptide fragment, IRF-2(113), may be a good material for investigation of the DNA binding domain of IRF-2 and of the DNA-protein interaction...
  36. pmc Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences
    Y Fujii
    Department of Molecular Biology, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, USA
    EMBO J 18:5028-41. 1999
    ..Our results provide new insights into the structure and function of this family of transcription factors...
  37. ncbi Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene
    T Kawakami
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    FEBS Lett 358:225-9. 1995
    ..These results suggest that ISGF3 gamma or complex containing ISGF3 gamma is involved in the IRF-1-independent pathway mediating IFN-beta gene regulation...
  38. pmc Interferon regulatory factor (IRF)-1 and IRF-2 regulate interferon gamma-dependent cyclooxygenase 2 expression
    J C Blanco
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Exp Med 191:2131-44. 2000
    ..Our data demonstrate conclusively the importance of IFN-gamma as a direct activator and coactivator of the Cox-2 gene, and the central role of IRF-1/2 family members in this process...
  39. pmc Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells
    M Lohoff
    Institut für Klinische Mikrobiologie und Immunologie, Universitat Erlangen, 91054 Erlangen, Germany
    J Exp Med 192:325-36. 2000
    ..Mechanistically, IRF-2 may act as a functional agonist rather than antagonist of IRF-1 for some, but not all, IFN-stimulated regulatory element (ISRE)-responsive genes...
  40. ncbi CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling
    S Hida
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Immunity 13:643-55. 2000
    ..IRF-2 may represent a unique negative regulator, attenuating IFN-alpha/beta-induced gene transcription, which is necessary for balancing the beneficial and harmful effects of IFN-alpha/beta signaling in the immune system...
  41. ncbi Impaired class II transactivator expression in mice lacking interferon regulatory factor-2
    H Xi
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, Florida, FL33612, USA
    Oncogene 20:4219-27. 2001
    ..These data indicate that IRF-2, like IRF-1, plays a critical role in the regulation of the endogenous CIITA gene. The implications in understanding the previously described phenotypes of IRF-2 defective mice are discussed...
  42. ncbi Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis
    Jinkyung Ko
    Laboratory of Cellular and Molecular Immunology, Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
    J Immunol 168:2433-40. 2002
    ....
  43. ncbi Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family
    J Furui
    Institute for Protein Research, Osaka University, Suita, Osaka, 565, Japan
    Structure 6:491-500. 1998
    ..Elucidation of the structures of members of the IRF family is therefore useful to the understanding of the regulation and evolution of the immune system at the structural level...
  44. ncbi The role of the interferon regulatory factors, IRF-1 and IRF-2, in LPS-induced cyclooxygenase-2 (COX-2) expression in vivo and in vitro
    Shuling Zhang
    Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland 21201, USA
    J Endotoxin Res 8:379-88. 2002
    ..Collectively, these data provide evidence for an important role for IRF-1 in vivo and in vitro and for IRF-2 in vitro in the regulation of COX-2 expression by LPS...
  45. ncbi Interferon regulatory factor-2 regulates cell growth through its acetylation
    Atsuko Masumi
    Department of Safety Research on Biologics, National Institute of Infectious Diseases, Tokyo, Japan
    J Biol Chem 278:25401-7. 2003
    ..These results indicate that IRF-2 is acetylated in a cell growth-dependent manner, which enables it to contribute to transcription of cell growth-regulated promoters...
  46. ncbi Regulation of lipopolysaccharide sensitivity by IFN regulatory factor-2
    Natalia Cuesta
    Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
    J Immunol 170:5739-47. 2003
    ..Collectively, these findings reveal a critical role for IRF-2 in endotoxicity, and point to a previously unappreciated role for IRF-2 in the regulation of apoptosis...
  47. ncbi Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy
    Ali A Ashkar
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 171:2937-44. 2003
    ..These studies indicate that uNK cell development and maturation share some aspects with NK cell development in other tissues, but also display distinctive tissue-specific regulation...
  48. pmc Negative regulation of IFN-alpha/beta signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells
    Kenya Honda
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 101:2416-21. 2004
    ....
  49. pmc Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for IFN regulatory factor-2
    Eri Ichikawa
    Department of Immunology and Infectious Diseases, Shinshu University Graduate School of Medicine, Asahi 3 1 1, Matsumoto, Nagano 390 8621, Japan
    Proc Natl Acad Sci U S A 101:3909-14. 2004
    ..Our current findings thus pointed to a previously unknown unique cell-type-selective multimode function of IRF-2 in the regulation of lymphohematopoiesis...
  50. ncbi B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites
    Tracy C Kuo
    Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Immunol 173:5556-63. 2004
    ..Thus, our data suggest that Blimp-1 competes in vivo with a subset of IRF proteins and help predict the sites and IRF family members that may be affected...
  51. ncbi IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression during phorbol ester-induced promyelocytic HL-60 differentiation
    Myung Chul Chung
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    J Biol Chem 279:56042-52. 2004
    ..Together, these results indicate that IRF-2 contributes to transcriptional activation of the NMHC-A gene via 32kb-150 during TPA-induced differentiation of HL-60 cells...