Itgb2

Summary

Gene Symbol: Itgb2
Description: integrin beta 2
Alias: 2E6, AI528527, Cd18, LAD, LCAMB, Lfa1, MF17, integrin beta-2, Mac-1 beta, cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, complement receptor C3 subunit beta, lymphocyte function associated antigen 1, macrophage antigen-1 beta
Species: mouse

Top Publications

  1. ncbi Gene targeting yields a CD18-mutant mouse for study of inflammation
    R W Wilson
    Department of Internal Medicine, Baylor College of Medicine, Houston, TX 77030
    J Immunol 151:1571-8. 1993
  2. ncbi Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune insulitis of NOD mice and association with both Th1- and Th2-type infiltrates
    S Martin
    Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    J Autoimmun 9:637-43. 1996
  3. ncbi A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation
    A Coxon
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Immunity 5:653-66. 1996
  4. pmc LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice
    H Lu
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 99:1340-50. 1997
  5. pmc Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice
    J P Mizgerd
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Exp Med 186:1357-64. 1997
  6. ncbi Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration
    Z M Ding
    Speros P Martel Laboratory of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 163:5029-38. 1999
  7. ncbi Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient mice
    T Papayannopoulou
    Division of Hematology, University of Washington, Seattle, WA 98195 7710, USA
    Blood 97:1282-8. 2001
  8. ncbi Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins
    T Papayannopoulou
    Division of Hematology, University of Washington, Seattle 98195 7710, USA
    Blood 98:2403-11. 2001
  9. ncbi Role of alpha4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endothelium
    Robert A Bowden
    Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Circ Res 90:562-9. 2002
  10. ncbi Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization
    Eiji Sakurai
    Department of Ophthalmology, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    Invest Ophthalmol Vis Sci 44:2743-9. 2003

Scientific Experts

Detail Information

Publications129 found, 100 shown here

  1. ncbi Gene targeting yields a CD18-mutant mouse for study of inflammation
    R W Wilson
    Department of Internal Medicine, Baylor College of Medicine, Houston, TX 77030
    J Immunol 151:1571-8. 1993
    b>CD18 is the common beta subunit for the heterodimeric leukocyte integrins that mediate many inflammatory cell adhesion responses including binding to intercellular adhesion molecules 1 and 2...
  2. ncbi Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune insulitis of NOD mice and association with both Th1- and Th2-type infiltrates
    S Martin
    Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    J Autoimmun 9:637-43. 1996
    ..ICAM-1 and LFA-1 expression is seen prior to L-selectin and VCAM-1. However, adhesion molecule expression during Th1 versus Th2 cell infiltration is very similar, suggesting similar adhesion molecule requirements of the two Th subsets...
  3. ncbi A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation
    A Coxon
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Immunity 5:653-66. 1996
    In mice selectively deficient in CD11b/CD18, a beta 2 integrin, chemoattractant-induced leukocyte adhesion to microvascular endothelium in vivo was reduced...
  4. pmc LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice
    H Lu
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 99:1340-50. 1997
    ..Our results demonstrate that Mac-1 plays a critical role in mediating binding of neutrophils to fibrinogen and neutrophil degranulation, but is not necessary for effective neutrophil emigration, which is more dependent upon LFA-1...
  5. pmc Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice
    J P Mizgerd
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Exp Med 186:1357-64. 1997
    To determine the role of CD11/CD18 complexes in neutrophil emigration, inflammation was induced in the skin, lungs, or peritoneum of mutant mice deficient in CD18 (CD18-/- mutants)...
  6. ncbi Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration
    Z M Ding
    Speros P Martel Laboratory of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 163:5029-38. 1999
    ..in embryonic stem cells, and neutrophil function was compared in vitro and in vivo with Mac-1-deficient, CD18-deficient, and wild-type mice...
  7. ncbi Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient mice
    T Papayannopoulou
    Division of Hematology, University of Washington, Seattle, WA 98195 7710, USA
    Blood 97:1282-8. 2001
    ..When the anti-beta2 (anti-CD11a or anti-CD18) or anti-alpha5/beta1 integrin antibody was combined with anti-alpha4, an augmentation in mobilization was seen ..
  8. ncbi Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins
    T Papayannopoulou
    Division of Hematology, University of Washington, Seattle 98195 7710, USA
    Blood 98:2403-11. 2001
    ..Although early deaths after transplantation can be seen in recipients deficient in CD18 and selectin, these are attributed to septic complications rather than homing defects...
  9. ncbi Role of alpha4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endothelium
    Robert A Bowden
    Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Circ Res 90:562-9. 2002
    ..Although leukocyte beta2 integrins (CD18) play a critical role, significant neutrophil emigration persists when CD18 is neutralized or absent...
  10. ncbi Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization
    Eiji Sakurai
    Department of Ophthalmology, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    Invest Ophthalmol Vis Sci 44:2743-9. 2003
    To investigate the role of the leukocyte adhesion molecules CD18 and intercellular adhesion molecule (ICAM)-1 in the development of choroidal neovascularization (CNV).
  11. ncbi Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms
    Imo E Hoefer
    Research Group for Experimental and Clinical Arteriogenesis at the Department of Cardiology, University of Freiburg, Freiburg, Germany
    Circ Res 94:1179-85. 2004
    ....
  12. ncbi Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes
    Huaizhu Wu
    Section of Atherosclerosis, Department of Medicine, Baylor College of Medicine, 6565 Fannin, Houston, TX 77030, USA
    J Immunol 173:297-306. 2004
    ..To evaluate the roles of each CD11/CD18 integrin in T cell-APC interactions, we tested the ability of splenocytes of CD11-knockout (KO) mice to respond to ..
  13. pmc Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease
    Christopher G Kevil
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Am J Pathol 165:609-16. 2004
    ..The phenotype of the LFA-1-deficient mice was similar to that observed in beta(2) integrin-deficient (CD18-null) MRL/MpJ-Fas(lpr) mice, suggesting a lack of redundancy among the beta(2) integrin family members and other ..
  14. ncbi LFA-1 on CD4+ T cells is required for optimal antigen-dependent activation in vivo
    Sravanthi Kandula
    Department of Medicine, Section of Gastroenterology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 173:4443-51. 2004
    ..allows for segregation of the migration and activation defects through the adoptive transfer of LFA-1-deficient (CD18(-/-)) CD4(+) T cells from DO11.10 Ag-specific TCR transgenic mice into wild-type BALB/c mice...
  15. pmc CD18 deficiency protects against multiple low-dose streptozotocin-induced diabetes
    Shayne C Barlow
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Am J Pathol 165:1849-52. 2004
    ..Here we report that a gene-targeted deficiency of the beta(2) integrin, CD18, protects against multiple low-dose streptozotocin-induced autoimmune diabetes...
  16. ncbi Manifestations of inflammatory arthritis are critically dependent on LFA-1
    Gerald M Watts
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:3668-75. 2005
    ..Using mice deficient in all beta2 integrins (CD18 null mice), we demonstrate that expression of these heterodimeric adhesion molecules is critical for arthritis ..
  17. ncbi CD18 is required for optimal development and function of CD4+CD25+ T regulatory cells
    Marissa Marski
    Department of Medicine, University of Chicago, IL 60637, USA
    J Immunol 175:7889-97. 2005
    ..LFA-1 (CD11a/CD18) is an adhesion molecule that plays an established role in T cell-mediated cell contact and in T cell activation...
  18. ncbi Two waves of neutrophil emigration in response to corneal epithelial abrasion: distinct adhesion molecule requirements
    Zhijie Li
    Section of Leukocyte Biology, Department of Pediatrics, Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 47:1947-55. 2006
    ..In this study, the contributions of two families of adhesion molecules to neutrophil emigration into the cornea were investigated...
  19. ncbi The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration
    Jurgen Schymeinsky
    Department of Physiology, Ludwig Maximilians Universitat Munchen, Schillerstr 44, D 80336 MUnchen, Germany
    Blood 108:3919-27. 2006
    Leukocyte adhesion via beta(2) integrins (CD11/CD18) activates the tyrosine kinase Syk. We found that Syk was enriched at the lamellipodium during N-formyl-Met-Leu-Phe-induced migration of neutrophil-like differentiated HL-60 cells...
  20. ncbi Platelet response to corneal abrasion is necessary for acute inflammation and efficient re-epithelialization
    Zhijie Li
    Section of Leukocyte Biology, Department of Pediatrics, Children s Nutrition Research Center, 1100 Bates, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 47:4794-802. 2006
    ..In this study, the contributions of P-selectin to neutrophil emigration into the cornea after central epithelial abrasion were investigated...
  21. pmc Lymphocyte function-associated antigen-1-dependent inhibition of corneal wound healing
    Zhijie Li
    Section of Leukocyte Biology, Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 2600, USA
    Am J Pathol 169:1590-600. 2006
    ..We investigated the contributions of lymphocyte function-associated antigen (LFA)-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) by analyzing wound closure in mice with targeted deletions of CD11a (CD11a-/-) or CD11b (..
  22. pmc Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs
    Attila Mocsai
    Department of Physiology, Semmelweis University School of Medicine, 1088 Budapest, Hungary
    Nat Immunol 7:1326-33. 2006
    ..Our data show that integrin signaling for the activation of cellular responses in neutrophils and macrophages proceeds by an immunoreceptor-like mechanism...
  23. pmc Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif
    Matthew J Flick
    Cincinnati Children s Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 117:3224-35. 2007
    ..Thus, fibrin(ogen) is an important, but context-dependent, determinant of arthritis, and one mechanism linking fibrin(ogen) to joint disease is coupled to alphaMbeta2-mediated inflammatory processes...
  24. pmc Neutrophil interactions with keratocytes during corneal epithelial wound healing: a role for CD18 integrins
    Matei S Petrescu
    Department of Pediatrics, Critical Care Section, Baylor College of Medicine, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 48:5023-9. 2007
    To determine the role of keratocytes and leukocyte beta(2) (CD18) integrins in neutrophil (PMN) migration through the corneal stroma after epithelial scrape injury.
  25. doi Rapid leukocyte migration by integrin-independent flowing and squeezing
    Tim Lämmermann
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Nature 453:51-5. 2008
    ..Myosin II-dependent contraction is only required on passage through narrow gaps, where a squeezing contraction of the trailing edge propels the rigid nucleus...
  26. doi Beta2-integrins contribute to skeletal muscle hypertrophy in mice
    Joseph S Marino
    Department of Kinesiology, The University of Toledo, Toledo, Ohio 43606, USA
    Am J Physiol Cell Physiol 295:C1026-36. 2008
    ..the synergist ablation model of hypertrophy and mice deficient in the common beta-subunit of beta(2)-integrins (CD18(-/-)), we found that overloaded muscles of wild-type mice had greater myofiber size, dry muscle mass, and total ..
  27. doi CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks
    Karen E Anderson
    Inositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom
    Blood 112:5202-11. 2008
    ..serum-derived antibodies, and effectively abolished in mouse neutrophils lacking the beta(2)-integrin common chain, CD18. A combination of PI3K isoform-selective inhibitors, mouse knock-outs, and RNA-interference indicated CD18-..
  28. pmc Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase
    Melissa R Sarantos
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    J Immunol 181:8660-9. 2008
    ..We conclude that dimeric bond clusters of LFA-1/ICAM-1 provide a key outside-in signal for orienting cytoskeletal dynamics that direct PMN extravasation at sites of inflammation...
  29. pmc MMP-9 sheds the beta2 integrin subunit (CD18) from macrophages
    Tomas Vaisar
    Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Mol Cell Proteomics 8:1044-60. 2009
    ..Biochemical studies confirmed that two transmembrane proteins, beta(2) integrin subunit (CD18) and amyloid protein precursor (APP), were enriched in the medium of M9A macrophages...
  30. doi Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells
    Markus Moser
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nat Med 15:300-5. 2009
    ..leukocytes is the hallmark of a rare autosomal recessive leukocyte adhesion deficiency syndrome in humans called LAD-III, characterized by severe bleeding and impaired adhesion of leukocytes to inflamed endothelia...
  31. pmc LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ
    Ronen Sumagin
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 185:7057-66. 2010
    ..Using function-blocking Abs, we show that these different crawling patterns were due to CD11a/CD18 (LFA-1)- versus CD11b/CD18 (Mac-1)-mediated crawling...
  32. doi Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae
    Keith B Boyle
    Inositide Laboratory, Babraham Institute, Cambridge CB22 3AT, United Kingdom
    J Immunol 186:2978-89. 2011
    ..Hyphal-induced ROS responses were substantially inhibited by deletion of the common β2-integrin subunit CD18, with only a minor, redundant role for Dectin-1...
  33. pmc Migrational guidance of neutrophils is mechanotransduced via high-affinity LFA-1 and calcium flux
    Neha Dixit
    Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA
    J Immunol 187:472-81. 2011
    ..We demonstrate how the shear stress of blood flow can transduce distinct outside-in signals at focal sites of high-affinity LFA-1 that provide contact-mediated guidance for neutrophil emigration...
  34. pmc Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling
    Sarah J McMillan
    Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    Blood 121:2084-94. 2013
    ..Our findings have implications for the human functional ortholog, siglec-9, and its potential role in regulating inflammatory lung disease...
  35. pmc β2 integrin-mediated cell-cell contact transfers active myeloperoxidase from neutrophils to endothelial cells
    Uwe Jerke
    Experimental and Clinical Research Center, Charité Medical Faculty, Berlin, Germany
    J Biol Chem 288:12910-9. 2013
    ..Neutrophils and ECs formed intimate contact sites demonstrated by electron microscopy. Blocking CD11b or CD18 β2 integrin chains, or using neutrophils from CD11b gene-deleted mice, reduced MPO transfer...
  36. pmc Vav GEFs are required for beta2 integrin-dependent functions of neutrophils
    M Angelica Martinez Gakidis
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    J Cell Biol 166:273-82. 2004
    ..Thus, Vav proteins play an essential role coupling beta2 to Rho GTPases and regulating multiple integrin-induced events important in leukocyte adhesion and phagocytosis...
  37. pmc A polygenic mouse model of psoriasiform skin disease in CD18-deficient mice
    D C Bullard
    Department of Molecular, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 93:2116-21. 1996
    Previously, a hypomorphic mutation in CD18 was generated by gene targeting, with homozygous mice displaying increased circulating neutrophil counts, defects in the response to chemically induced peritonitis, and delays in transplantation ..
  38. pmc Spontaneous skin ulceration and defective T cell function in CD18 null mice
    K Scharffetter-Kochanek
    Department of Molecular and Human Genetics, Houston, Texas 77030, USA
    J Exp Med 188:119-31. 1998
    A null mutation was prepared in the mouse for CD18, the beta2 subunit of leukocyte integrins. Homozygous CD18 null mice develop chronic dermatitis with extensive facial and submandibular erosions...
  39. ncbi Leukocyte-endothelial cell interactions - lessons from knockout mice
    A R Rosenkranz
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Exp Nephrol 7:125-36. 1999
    ..Second, we discuss models of experimental glomerulonephritis and what we have learned about leukocyte adhesion receptors in the pathogenesis of glomerulonephritis through studies in knockout mice...
  40. ncbi Impairment of neutrophil emigration in CD18-null mice
    B Walzog
    Department of Physiology, Freie Universitat Berlin, D 14195 Berlin, Germany
    Am J Physiol 276:G1125-30. 1999
    This study was undertaken to investigate the requirement of beta2-integrins (CD11/CD18) for extravasation of neutrophils in mice...
  41. pmc Hepatic leukostasis and hypoxic stress in adhesion molecule-deficient mice after gut ischemia/reperfusion
    Y Horie
    Department of Physiology, Louisiana State University Medical Center, Shreveport 71130, USA
    J Clin Invest 99:781-8. 1997
    ..all on a C57B1 background) that are deficient in either intracellular adhesion molecule-1, P-selectin, or CD11/CD18. The accumulation of fluorescently labeled leukocytes and the number of nonperfused sinusoids in livers of control ..
  42. ncbi Chronic inflammatory disease alters adhesion molecule requirements for acute neutrophil emigration in mouse skin
    J P Mizgerd
    Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 162:5444-8. 1999
    ..In contrast, emigration remained compromised in E/P/I mutants and CD18 mutants regardless of age or lesions...
  43. pmc Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1
    Athanasia D Panopoulos
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 277:19001-7. 2002
    ..capabilities, we studied inducible expression of the myeloid-specific marker, integrin alpha(M)beta(2) (CD11b/CD18, Mac-1), in the myeloid cell line, 32D...
  44. ncbi Differential requirement for CD18 in T-helper effector homing
    Seung Hyo Lee
    Biology of Inflammation Center and Department of Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Med 9:1281-6. 2003
    ..CD18-deficient (Itgb2(-/-)) T cells showed largely normal in vitro function...
  45. ncbi CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis
    Daniel Kess
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Immunol 171:5697-706. 2003
    In a CD18 hypomorphic polygenic PL/J mouse model, the severe reduction of CD18 (beta(2) integrin) to 2-16% of wild-type levels leads to the development of a psoriasiform skin disease...
  46. ncbi ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18
    Pratima Kodali
    Liver Center, University of California, CA 94110, USA
    Am J Physiol Gastrointest Liver Physiol 291:G355-63. 2006
    ..The objective of this study was to determine whether the beta2-integrin CD18, which plays an important role in leukocyte invasion and cytotoxicity, contributes to ANIT-induced hepatic ..
  47. pmc Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins
    Eun Young Choi
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 111:3607-14. 2008
    ..In conclusion, Cbl-b deficiency activates LFA-1 and LFA-1-mediated inflammatory cell recruitment by stimulating the interaction between the LFA-1 beta-chain and 14-3-3 proteins...
  48. pmc Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules
    Ilia N Buhtoiarov
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    J Immunol 182:1940-53. 2009
    ..Furthermore, simultaneous blocking of interactions between CD40-CD154, NKG2D-H60, and CD18-ICAM-1/2 led to complete abrogation of Mphi-mediated NO secretion and complete inhibition of Mphi-mediated tumor ..
  49. doi Osteopontin enhances phagocytosis through a novel osteopontin receptor, the alphaXbeta2 integrin
    Lotte Schack
    Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
    J Immunol 182:6943-50. 2009
    ..We identify the integrin alpha(X)beta(2) (CD11c/CD18), which is highly expressed on the cell surface of monocytes, as a novel OPN receptor...
  50. pmc LFA-1-dependent Ca2+ entry following suboptimal T cell receptor triggering proceeds without mobilization of intracellular Ca2+
    Kwangmi Kim
    Department of Chemistry and Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 284:22149-54. 2009
    ..These results ensure the unique role of LFA-1 in T cell Ca2+ signaling and reveal that LFA-1-dependent Ca2+ entry proceeds via a mechanism separate from store-operated Ca2+ entry...
  51. pmc SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility
    Hongyan Wang
    Cell Signaling Section, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    Proc Natl Acad Sci U S A 106:12436-41. 2009
    ..Our findings provide evidence of an obligatory role for the SLP-76-ADAP module in LFA-1-mediated costimulation in T cells...
  52. pmc Beta2 integrins modulate the initiation and progression of atherosclerosis in low-density lipoprotein receptor knockout mice
    Aksam Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, R630, Houston, TX 77030, USA
    Cardiovasc Res 85:853-63. 2010
    ..Here, we investigated the effect of inactivation of beta2 integrins at different stages of atherosclerosis by timed bone marrow transplantation (BMT) of CD18(-/-) cells in low-density lipoprotein receptor knockout (LDLR(-/-)) mice.
  53. pmc Murine IgG1 and IgG3 isotype switch variants promote phagocytosis of Cryptococcus neoformans through different receptors
    Carolyn A Saylor
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 184:336-43. 2010
    ..IgG3 was an efficient opsonin for C. neoformans in FcgammaR- and CD18-deficient cells and in the presence of blocking Abs to FcgammaR and complement receptor...
  54. pmc Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms
    Lequn Li
    Department of Hematology Oncology and Cancer Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Immunol 266:7-13. 2010
    ....
  55. doi Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling
    Jan M Herter
    Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Munster, Germany
    Blood 121:2301-10. 2013
    ..We conclude that P-Rex1 serves distinct functions in LFA-1 and Mac-1 activation...
  56. pmc The β2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo
    Vicky Louise Morrison
    Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
    Blood 122:1428-36. 2013
    ....
  57. doi The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via β2 integrins (CD11/CD18)
    Ludwig T Weckbach
    Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, and
    Blood 123:1887-96. 2014
    ..Thus, MK seems to support PMN adhesion by promoting the high affinity conformation of β2 integrins, thereby facilitating PMN trafficking during acute inflammation. ..
  58. doi Functional Beta2-Integrins Restrict Skin Inflammation In Vivo
    Terhi S Savinko
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Invest Dermatol 135:2249-57. 2015
    ..Functional beta2-integrins also have a major role in restricting the immune response in the inflamed skin and lymph nodes in vivo, likely through effects on mast cell and dendritic cell numbers and activation. ..
  59. doi Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs
    Ekaterina Petrovich
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    FASEB J 30:1767-78. 2016
    ..Li, J.-P., Engelhardt, B., Vlodavsky, I., Alon, R. Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs. ..
  60. pmc Metalloproteinase-mediated Shedding of Integrin β2 promotes macrophage efflux from inflammatory sites
    Ivan G Gomez
    Dept of Pathology, University of Washington, Harborview Medical Center, 325 9th Ave, Box 359675, Seattle, WA 98104, USA
    J Biol Chem 287:4581-9. 2012
    ..Thus, our study demonstrates the ability of metalloproteinase-mediated shedding of integrin β2 to promote macrophage efflux from inflammatory sites, and the release of soluble integrin heterodimers may also limit local inflammation...
  61. pmc Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation
    Craig T Lefort
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Blood 119:4275-82. 2012
    ..We conclude that talin-1 and kindlin-3 serve distinct functions in LFA-1 activation...
  62. pmc Ly6G ligation blocks recruitment of neutrophils via a β2-integrin-dependent mechanism
    Jun Xia Wang
    Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Blood 120:1489-98. 2012
    ....
  63. pmc Leukocyte function antigen-1, kindlin-3, and calcium flux orchestrate neutrophil recruitment during inflammation
    Neha Dixit
    Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA
    J Immunol 189:5954-64. 2012
    Neutrophil arrest and migration on inflamed endothelium involves a conformational shift in CD11a/CD18 (leukocyte function antigen-1; LFA-1) to a high-affinity and clustered state that determines the strength and lifetime of bond formation ..
  64. pmc α7 helix region of αI domain is crucial for integrin binding to endoplasmic reticulum chaperone gp96: a potential therapeutic target for cancer metastasis
    Feng Hong
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 288:18243-8. 2013
    ..Thus, targeting the binding site of α7 helix of AID on gp96 is potentially a new strategy for treatment of cancer metastasis. ..
  65. ncbi Mouse macrophage beta subunit (CD11b) cDNA for the CR3 complement receptor/Mac-1 antigen
    D L Zeger
    Department of Biological Sciences, University of California, Santa Barbara 93106
    Immunogenetics 31:191-7. 1990
    ..CD11b) of the mouse LFA-1/Mac-1/p150,95 group of leukocyte cell adhesion receptors, formally designated integrin beta 2, has been cloned and sequenced...
  66. ncbi Beta2 integrins and ICAM-1 are involved in establishment of the intestinal mucosal T cell compartment
    J W Huleatt
    Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington 06030, USA
    Immunity 5:263-73. 1996
    Development of the mucosal immune system was examined in mice with partial loss of expression of ICAM-1 or CD18. Profound effects on Peyer's patch (PP), lamina propria (LP), and intraepithelial lymphocyte (IEL) T cell populations were ..
  67. ncbi Mouse CD23 regulates monocyte activation through an interaction with the adhesion molecule CD11b/CD18
    S Lecoanet-Henchoz
    Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development, Switzerland
    Eur J Immunol 27:2290-4. 1997
    ..Here, we demonstrate that CD11b, the alpha chain of the beta 2 integrin adhesion molecule complex CD11b/CD18 expressed on monocytes interacts with CD23...
  68. ncbi Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice
    A R Rosenkranz
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 161:6463-7. 1998
    Mac-1 (CD11b/CD18, CR3), a beta2 integrin expressed on leukocytes, is important in leukocyte migration...
  69. ncbi Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression
    N Bhat
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 162:7335-42. 1999
    ..photoactivatable Taxol analogue failed to bind to CD14, the prominent Taxol-binding protein was identified as CD18, the approximately 96-kDa common component of the beta2 integrin family...
  70. ncbi Beta2 integrin modulates platelet caspase activation and life span in mice
    P F Piguet
    Department of Pathology, University of Geneva, Switzerland
    Eur J Cell Biol 80:171-7. 2001
    We explored the role of CD18 (beta2 integrin) in platelet physiology, using mice genetically deficient in CD18 (CD18 -/-), or its main ligand CD54 (ICAM-1, CD54 -/-)...
  71. ncbi Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation
    A Coxon
    Department of Pathology, Brigham and Women s Hospital and, Harvard Medical School, 221 Longwood Avenue, 02115, Boston, MA, USA
    Immunity 14:693-704. 2001
    ..Thus, the interaction of immune complexes with Fc gamma RIII may mediate early neutrophil recruitment in immune complex-mediated inflammation...
  72. ncbi TGF-beta3 is required for the adhesion and intercalation of medial edge epithelial cells during palate fusion
    Consuelo Tudela
    Departamento de Ciencias Morfológicas I, Facultad de Medicina, Universidad Complutense de Madrid, Spain
    Int J Dev Biol 46:333-6. 2002
    ..Thus, the substantial alteration of MEE intercellular adhesion observed in TGF-beta3 -/- palates may account for the defect in palatal shelf adhesion and the formation of cleft palate...
  73. ncbi A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo
    LiLi Tu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 169:2034-43. 2002
    ..These results suggest that sL-selectin influences lymphocyte migration in vivo and that the increased sL-selectin levels present in certain pathologic conditions may adversely affect leukocyte migration...
  74. ncbi The role of selectins and integrins in adenovirus vector-induced neutrophil recruitment to the liver
    Yang Li
    Gastrointestinal Research Group, Department of Medicine, University of Calgary, Calgary, Canada
    Eur J Immunol 32:3443-52. 2002
    ..In contrast, adenovirus vector-induced leukocyte adhesion was unchanged in CD18-knockout mice...
  75. ncbi Acute mast cell-dependent neutrophil recruitment in the skin is mediated by KC and LFA-1: inhibitory mechanisms of dexamethasone
    Rene Schramm
    Department of Surgery, Malmo University Hospital, Sweden
    J Leukoc Biol 72:1122-32. 2002
    ..Thus, this study elucidates important interactions between chemokines and adhesion molecules in mast cell-dependent neutrophil recruitment and provides new insight into mechanisms of dexamethasone in skin inflammation...
  76. ncbi Natural killer cells and B lymphocytes in L-selectin and Mac-1/LFA-1 knockout mice: marker-dependent, but not cell lineage-dependent changes in the spleen and bone marrow
    Duncan Lejtenyi
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Immunobiology 207:129-35. 2003
    ..the aim of the present study to quantify, in knock-out mice deficient for either the L-selectin addressin, or the CD18:Mac-1/LFA-1 integrins, NK cells and B cells in both the spleen and their bone marrow birth site...
  77. ncbi Highly biased type 1 immune responses in mice deficient in LFA-1 in Listeria monocytogenes infection are caused by elevated IL-12 production by granulocytes
    Masashi Emoto
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 171:3970-6. 2003
    LFA-1 (CD11a/CD18) plays a key role in various inflammatory responses. Here we show that the acquired immune response to Listeria monocytogenes is highly biased toward type 1 in the absence of LFA-1...
  78. ncbi Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1
    Shuangping Shi
    Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    J Immunol 175:3318-28. 2005
    ....
  79. ncbi Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in beta2 integrin-deficient mice
    Thorsten Peters
    Department of Dermatology, and Allergic Diseases, University of Ulm, Maienweg 12, 89081 Ulm, Germany
    J Leukoc Biol 80:599-607. 2006
    Absence of the common beta chain (CD18) of beta(2) integrins leads to leukocyte-adhesion deficiency type-1 (LAD1) in humans...
  80. ncbi RhoH is important for positive thymocyte selection and T-cell receptor signaling
    Tatjana Dorn
    Max Planck Institute of Biochemistry, Heisenberg Group Regulation of Cytoskeletal Organization, Martinsried, Germany
    Blood 109:2346-55. 2007
    ..These data suggest that RhoH is important for pre-TCR and TCR signaling because it allows the efficient interaction of ZAP70 with the LAT signalosome, thus regulating thymocyte development...
  81. ncbi Mouse models of psoriasis
    Johann E Gudjonsson
    Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Invest Dermatol 127:1292-308. 2007
    ..In this review, we describe various animal models, detail the immunologic and intracellular pathways that mediate these phenotypes and assess the utility of these models to better understand this disease...
  82. ncbi Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces
    Eilon Woolf
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Immunol 8:1076-85. 2007
    ..Thus, lymph node chemokines that promote motility and strongly activate lymphocyte integrins under shear forces fail to stimulate stable integrin adhesiveness in extravascular shear-free environments...
  83. pmc CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages
    Eric Vachon
    Division of Respirology, Department of Medicine, University of Toronto, Toronto, ON, Canada
    Blood 110:4492-502. 2007
    Diverse receptors, including Fcgamma receptors and beta(2) integrins (complement receptor-3 [CR3], CD11b/CD18), have been implicated in phagocytosis, but their distinct roles and interactions with other receptors in particle engulfment ..
  84. ncbi Differential expression of beta 2-integrins and cytokine production between gammadelta and alphabeta T cells in experimental autoimmune encephalomyelitis
    Sherry S Smith
    Department of Microbiology, University of Alabama at Birmingham, 845 19th St S, BBRB 842, Birmingham, AL 35294, USA
    J Leukoc Biol 83:71-9. 2008
    ..These results suggest unique roles for beta 2-integrins in the trafficking of gammadelta versus alphabeta T cells during EAE and that gammadelta T cells infiltrate the CNS rapidly, producing cytokines, which modulate acute disease...
  85. pmc Beta2 integrins separate graft-versus-host disease and graft-versus-leukemia effects
    Yaming Liang
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    Blood 111:954-62. 2008
    ..We asked whether CD18-deficient T cells would induce less GVHD while sparing the graft-versus-leukemia (GVL) effect...
  86. ncbi IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice
    Emily Smith
    Robert M Berne Cardiovascular Research Center, Department of Biomedical Engineering, University of Virginia, Charlottesville 22908, USA
    J Immunol 179:8274-9. 2007
    ..This homeostatic system is disrupted in mice lacking adhesion molecules like beta2-integrins (Itgb2-/-) which have defective neutrophil trafficking and neutrophilia...
  87. ncbi [LFA-1 and VLA-4 involved in vasoendothelial adhesion and transendothelial migration of human high proliferative potential endothelial progenitor cells]
    Hua Xin Duan
    Department of Hematology, The First Guangzhou Municipal People Hospital, Guangzhou Medical College, Guangzhou 510180, Guangdong Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:671-5. 2008
    ..05). It is concluded that both LFA-1 and VLA-4 are involved in vasoendothelial adhesion and transendothelial migration of HPP-EPCs...
  88. doi The role of Mac-1 (CD11b/CD18) in osteoclast differentiation induced by receptor activator of nuclear factor-kappaB ligand
    Hidetaka Hayashi
    Department of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Tokyo 113 8549, Japan
    FEBS Lett 582:3243-8. 2008
    ..CD11a and CD11b, osteoclastogenesis induced by M-CSF and RANKL was inhibited in the presence of anti-CD11b or anti-CD18 but not anti-CD11a antibodies...
  89. doi Requirement of myeloid cells for axon regeneration
    Benoit Barrette
    Department of Anatomy and Physiology, Laval University, Ste Foy, Quebec G1V4G2, Canada
    J Neurosci 28:9363-76. 2008
    ..Therefore, myeloid cells support axonal regeneration and functional recovery by creating a growth-permissive milieu for injured axons...
  90. doi Wound healing defect of Vav3-/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils
    Anca Sindrilaru
    Department of Dermatology and Allergic Diseases, University of Ulm, Germany
    Blood 113:5266-76. 2009
    ..Moreover, local injection of Vav3(-/-) or beta(2)-integrin(CD18)(-/-) macrophages into wound margins failed to restore the healing defect of Vav3(-/-) mice, suggesting Vav3 to ..
  91. pmc Extracellular matrix lumican deposited on the surface of neutrophils promotes migration by binding to beta2 integrin
    Seakwoo Lee
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 284:23662-9. 2009
    ..We also found that peritoneal PMNs do not express lumican, whereas endothelial cells do. Taken together these observations suggest a novel endothelial lumican-mediated paracrine regulation of neutrophils early on in their migration path...
  92. doi Human neutrophils kill Streptococcus pneumoniae via serine proteases
    Alistair J Standish
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Immunol 183:2602-9. 2009
    ..Our findings show that Gram-positive pathogens are killed by human neutrophils via different mechanisms involving serine proteases...
  93. pmc Innate immune cells induce hemorrhage in tumors during thrombocytopenia
    Benoit Ho-Tin-Noe
    Immune Disease Institute, Boston, MA 02115, USA
    Am J Pathol 175:1699-708. 2009
    ..Our results show that platelets counteract tumor-associated inflammation and that the absence of this platelet function elicits vascular injuries by tumor-infiltrating innate immune cells...
  94. pmc Beta(2) integrin deficiency yields unconventional double-negative T cells distinct from mature classical natural killer T cells in mice
    Tsvetelina Oreshkova
    Department of Dermatology and Allergic Diseases, Ulm University, D 89081 Ulm, Germany
    Immunology 128:271-86. 2009
    Expressed on leucocytes, beta(2) integrins (CD11/CD18) are specifically involved in leucocyte function...
  95. pmc Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways
    Helena Mueller
    Department of Anesthesiology and Intensive Care Medicine, University of Munster, 48149 Munster, Germany
    Blood 115:3118-27. 2010
    ..Our data demonstrate the functional importance of this newly identified signaling pathway mediated by E-selectin engagement...
  96. pmc Phosphorylation of paxillin at threonine 538 by PKCdelta regulates LFA1-mediated adhesion of lymphoid cells
    Larisa Y Romanova
    Laboratory of Cancer Biology and Genetics, Cell and Cancer Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    J Cell Sci 123:1567-77. 2010
    ..We also show that phosphorylation of T538 is involved in the activation of LFA-1 integrins by TPA...
  97. pmc Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice
    Philippe Krebs
    Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 117:6582-8. 2011
    ..We show that neither the integrin CD18, which is involved in adhesion between antigen-presenting cells and effector T cells, nor tumor necrosis factor (..
  98. pmc Molecular basis for the interaction of low density lipoprotein receptor-related protein 1 (LRP1) with integrin alphaMbeta2: identification of binding sites within alphaMbeta2 for LRP1
    Sripriya Ranganathan
    Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 286:30535-41. 2011
    ..Indeed, we further demonstrate that the soluble form of LRP1 (sLRP1) inhibits α(M)β(2)-mediated adhesion of cells to fibrinogen. These studies suggest that sLRP1 may attenuate inflammation by modulating integrin function...
  99. ncbi Mouse macrophage beta subunit (CD11b) cDNA for the CR3 complement receptor/Mac-1 antigen
    R Kofler
    Immunogenetics 33:77-8. 1991
  100. ncbi Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21
    D S Threadgill
    Department of Veterinary Pathology, Texas A and M University, College Station 77843
    Genomics 11:1143-8. 1991
    ..FIM3, SI, and CP mapped to bovine syntenic group U10, while RAF1 and GPX1 mapped to U12...
  101. pmc CR3-dependent resistance to acute Toxoplasma gondii infection in mice
    L L Johnson
    Trudeau Institute, Inc, Saranac Lake, New York 12983, USA
    Infect Immun 64:1998-2003. 1996
    ..The inflammation, degeneration, and necrosis in most of the anti-CR3-treated mice were severe enough to account for the observed mortalities...

Research Grants7

  1. CO POISONING IN THE CONTEXT OF A REPERFUSION INJURY
    Stephen Thom; Fiscal Year: 2003
    ..The research plan is aimed to test the hypothesis that immune responses and the associated oxidative stress cause neurological injuries. ..
  2. ENHANCEMENT OF ANTI-TUMOR IMMUNOTHERAPIES
    Hui Xu; Fiscal Year: 2005
    ..The outcome may provide valuable information for improving the efficiency and clinical response of tumor immunotherapies. ..
  3. GLOBIN SWITCHING AND ERYTHROID DIFFERENTIATION
    Thalia Papayannopoulou; Fiscal Year: 2002
    ....
  4. BIOLOGICAL PROPERTIES AND REGULATION OF STEM CELLS
    Thalia Papayannopoulou; Fiscal Year: 2009
    ..We believe that the proposed studies will enhance our understanding and provide a more comprehensive picture of the influence of <x4 integrins on prenatal and postnatal hematopoiesis. ..
  5. Immuno-enhancement of skin patch anthrax vaccination
    Hui Xu; Fiscal Year: 2002
    ..Ultimately, this protocol may also be applied for skin-patch vaccines to other pathogens and tumor antigens. ..
  6. ALLERGIC CONTACT DERMATITIS: MECHANISMS OF ELICITATION
    Hui Xu; Fiscal Year: 2008
    ..On a clinical level, the outcome of the proposal may lead to development of immunotherapeutic approaches for antigen specific desensitization of allergic contact dermatitis patients. ..
  7. THE ROLE OF IL-17 PRODUCING T LYMPHOCYTES IN ALLERGIC CONTACT DERMATITIS
    Hui Xu; Fiscal Year: 2008
    ..The outcome may provide information for new therapeutic strategies for inflammatory diseases. [unreadable] [unreadable] [unreadable]..