Genomes and Genes
Gene Symbol: Kcnb1
Description: potassium voltage gated channel, Shab-related subfamily, member 1
Alias: Kcr1-1, Kv2.1, Shab, potassium voltage-gated channel subfamily B member 1, voltage-gated potassium channel subunit Kv2.1
- Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal NeuronsHannah I Bishop
Department of Neurobiology, Physiology and Behavior and
J Neurosci 35:14922-42. 2015..2 in intratelencephalic and pyramidal tract neurons of L5, indicating circuit-specific requirements for these Kv2 paralogs. Together, these results support distinct roles for these two Kv2 channel family members in mammalian cortex...
- AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related PhenotypesMarjaana A Peltola
Neuroscience Center, University of Helsinki, Helsinki, Finland
Schizophr Bull 42:191-201. 2016..Concomitantly, we have detected an association of a rare, population-specific polymorphism of KV2.1 (KCNB1) with human schizophrenia in a genetic isolate enriched with schizophrenia...
- Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetesMadeline Nieves-Cintrón
From the Department of Pharmacology, University of California, Davis, California 95616
J Biol Chem 290:7918-29. 2015..Together, our study supports the concept that transcriptional suppression of KV2.1 by activation of the AKAP150-CaN/NFATc3 signaling axis contributes to enhanced arterial tone during diabetes. ..
- Partial blockade of Kv2.1 channel potentiates GLP-1's insulinotropic effects in islets and reduces its dose required for improving glucose tolerance in type 2 diabetic male miceRauza Sukma Rita
Division of Integrative Physiology R S R, K D, T K, T Y, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan Department of Internal Medicine M K, Saitama Medical Center, Jichi Medical University School of Medicine, Saitama 337 8503, Japan and Department of Development Physiology T Y, Division of Adaptation Development, National Institute for Physiological Sciences, Okazaki, Aichi 444 8585, Japan
Endocrinology 156:114-23. 2015..1 channels dramatically raises insulinotropic potency of GLP-1-based drugs, which opens a new avenue to reduce their doses and associated adverse effects while achieving the same glycemic control in type 2 diabetes...
- High temperature sensitivity is intrinsic to voltage-gated potassium channelsFan Yang
Department of Physiology and Membrane Biology, University of California, Davis School of Medicine, Davis, United States
elife 3:e03255. 2014....
- Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptorsDanielle Mandikian
Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, 95616
J Comp Neurol 522:3555-74. 2014..1 to dynamically impact intrinsic excitability...
- Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitabilityD J Speca
Department of Neurobiology, Physiology and Behavior, College of Biological Sciences
Genes Brain Behav 13:394-408. 2014..1(-/-) mice exhibit accelerated seizure progression. Together, these findings suggest homeostatic suppression of elevated neuronal activity by Kv2.1 plays a central role in regulating neuronal network function...
- AMIGO is an auxiliary subunit of the Kv2.1 potassium channelMarjaana A Peltola
Neuroscience Center, University of Helsinki, PO Box 56, Helsinki FI 00014, Finland
EMBO Rep 12:1293-9. 2011..In conclusion, our data indicate AMIGO as a function-modulating auxiliary subunit for Kv2.1 and thus provide new insights into regulation of neuronal excitability...
- The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic isletsXiaoyan Nina Li
Department of Metabolic Disorders, Merck Research Laboratories, Rahway, New Jersey, USA
J Pharmacol Exp Ther 344:407-16. 2013..2 modulates somatostatin release in δ-cells. Development of selective Kv2.1 inhibitors without cross inhibition of Kv2.2 may provide new avenues to promote GSIS for the treatment of type 2 diabetes...
- Biochemical characterization of the native Kv2.1 potassium channelJean Ju Chung
Department of Neuroscience and High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
FEBS J 272:3743-55. 2005..1 subunits but not homologous Kv2.2 subunits. The proteins precipitated by anti-Kv2.1 and their physiological relevance are of interest for further investigation...
- The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical functionX Q Dai
Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada T6G 2E1
Diabetologia 55:1709-20. 2012..We hypothesised that this interaction mediates insulin secretion independently of Kv2.1 electrical function...
- Expression and function of K(V)2-containing channels in human urinary bladder smooth muscleKiril L Hristov
Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, 29208, USA
Am J Physiol Cell Physiol 302:C1599-608. 2012..These findings reveal that ScTx1-sensitive K(V)2-containing channels are key regulators of human DSM excitability and contractility and may represent new targets for pharmacological or genetic intervention for bladder dysfunction...
- Molecular mechanisms underlying the apoptotic effect of KCNB1 K+ channel oxidationXilong Wu
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neuroscience and Cell Biology, 683 Hoes Ln W, Piscataway, New Jersey 08854, USA
J Biol Chem 288:4128-34. 2013Potassium (K(+)) channels are targets of reactive oxygen species in the aging nervous system. KCNB1 (formerly Kv2...
- Functional differences in Kv1.5 currents expressed in mammalian cell lines are due to the presence of endogenous Kv beta 2.1 subunitsV N Uebele
Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 271:2406-12. 1996..1 subunit can alter Kv1.5 alpha subunit function, 2) beta subunits are not required for alpha subunit expression, and 3) endogenous beta subunits are expressed in heterologous expression systems used to study K+ channel function...
- Formation of Kv2.1-FAK complex as a mechanism of FAK activation, cell polarization and enhanced motilityJian Feng Wei
Key Laboratory of Combined Multi organ Transplantation of Ministry of Health China, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
J Cell Physiol 217:544-57. 2008..1 expression and co-localization of Kv2.1 and FAK significantly enhanced directional cell migration and wound closure. It is suggested that the Kv2.1 channel may function as a promoting signal for FAK activation and cell motility...
- Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activationXinyang Hu
Department of Cardiology, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China
Am J Physiol Cell Physiol 301:C362-72. 2011..These findings provide novel evidence that HP enhances the ability of BMSCs to migrate and home to the injured region; this effect is mediated through a regulatory role of Kv2.1 on FAK phosphorylation/activation...
- Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responsesDavid A Jacobson
Deparment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232 0615, USA
J Physiol 588:3525-37. 2010..8-fold with apamin. These results uncover important repolarizing roles for both Kv and K(Ca) channels and identify distinct roles for SK channel activity in regulating calcium- versus sodium-dependent AP firing...
- Regulation of Kv2.1 phosphorylation in an animal model of anoxiaTakashi Ito
Department of Pharmacology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
Neurobiol Dis 38:85-91. 2010..These results suggest that Kv2.1 is tightly regulated in a clinically relevant animal model of anoxia and further implicate its role in the homeostasis of neurons during anoxic stress...
- A cluster of cholinergic premotor interneurons modulates mouse locomotor activityLaskaro Zagoraiou
Howard Hughes Medical Institute, Kavli Institute for Brain Science, Department of Neuroscience, Columbia University, New York, NY 10032, USA
Neuron 64:645-62. 2009..Thus, V0(C) interneurons represent a defined class of spinal cholinergic interneurons with an intrinsic neuromodulatory role in the control of locomotor behavior...
- Angiotensin II exerts glucose-dependent effects on Kv currents in mouse pancreatic beta-cells via angiotensin II type 2 receptorsKwan Yi Chu
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
Am J Physiol Cell Physiol 298:C313-23. 2010..These data suggest that hyperglycemia alters beta-cell function through modification of the K(v) channel which may be associated with the RAS...
- The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constrictionAnna N Bukiya
The University of Tennessee Health Science Center, College of Medicine, Department of Pharmacology, Memphis, TN 38163, USA
FEBS Lett 583:2779-84. 2009..Knocking-down KCNMB1 suppresses EtOH-reduction of arterial myocyte BK current and vessel diameter. Therefore, BK beta(1) is the molecular effector of alcohol-induced BK current inhibition and cerebrovascular constriction...
- Modification of Kv2.1 K+ currents by the silent Kv10 subunitsEleazar Carmelo Vega-Saenz de Miera
Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
Brain Res Mol Brain Res 123:91-103. 2004..The gene that encodes for Kv10.1 mRNAs maps to chromosome 2p22.1 in human, 6q12 in rat and 17E4 in mouse, locations consistent with the known systeny for human, rat and mouse chromosomes...
- A mouse brain homolog of the Drosophila Shab K+ channel with conserved delayed-rectifier propertiesM D Pak
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110
J Neurosci 11:869-80. 1991We have cloned and expressed a mouse brain K+ channel that is the homolog of the Drosophila Shab K+ channel...
- K+ current diversity is produced by an extended gene family conserved in Drosophila and mouseA Wei
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110
Science 248:599-603. 1990The Drosophila Shaker gene on the X chromosome has three sister genes, Shal, Shab, and Shaw, which map to the second and third chromosomes...
- Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1, Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal imprinting region of mouse chromosome 2 are not monoallelically expressedC M Williamson
MRC Radiobiology Unit, Didcot, Oxon, UK
Genet Res 65:83-93. 1995..that express transcription factors, 2 genes (Cyp24 and Pck1) that are involved in growth, 5 genes (Acra4, Edn3, Kcnb1, Mc3r and Ntsr) where a defect could lead to neurological and probably behavioural problems, and 3 genes (Cd40, ..
- Expression and function of pancreatic beta-cell delayed rectifier K+ channels. Role in stimulus-secretion couplingM W Roe
Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 271:32241-6. 1996..These studies implicate previously uncharacterized beta-cell delayed rectifier K+ channels in the regulation of membrane repolarization, [Ca2+]i, and insulin secretion...
- Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferationA Sobko
Neurobiology Department, Weizmann Institute of Science, Rehovot 76100, Israel
J Neurosci 18:10398-408. 1998..Here, we show that a large repertoire of K+ channel alpha subunits of the Shaker (Kv1.1, Kv1.2, Kv1.4, and Kv1.5), Shab (Kv2.1), and Shaw (Kv3.1b and Kv3.2) families is expressed in mouse SCs and sciatic nerve...
- Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunitH Xu
Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
Circ Res 85:623-33. 1999..In vivo telemetric recordings also reveal marked QT prolongation, consistent with a defect in ventricular repolarization, in Kv2.1N216FLAG-expressing transgenic mice...
- Identification of two chromosomal loci determining glucose intolerance in a C57BL/6 mouse strainT Kayo
Department of Hygiene, Akita University School of Medicine, Japan
Comp Med 50:296-302. 2000..05) at 10, 20, and 30 minutes during the intraperitoneal glucose tolerance test (IPGTT: 1.5 g glucose/kg of body weight)...
- Regional upregulation of Kv2.1-encoded current, IK,slow2, in Kv1DN mice is abolished by crossbreeding with Kv2DN miceJun Zhou
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Heart Circ Physiol 284:H491-500. 2003..1 polypeptide (Kv2DN) eliminated I(K,slow2). In summary, our data indicate that the spatially restrictive upregulation of Kv2.1-encoded currents underlies the increased dispersion of the repolarization observed in Kv1DN mice...
- Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neuronsElke Bocksteins
Laboratory for Molecular Biophysics, Physiology and Pharmacology, Department of Biomedical Sciences, University of Antwerp, Antwerpen 2610, Belgium
Am J Physiol Cell Physiol 296:C1271-8. 2009..1 channels, whereas the other component represents heterotetrameric K(v)2.1/silent K(v) channels. These observations support a physiological role for silent K(v) subunits in small DRG neurons...
- Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal lifeWilfried Mai
Animage Rhône Alpes Genopole, Unite Mixte de Recherche, Centre National de la Recherche Scientifique 5515, 59 Boulevard Pinel, 69003 Lyon, France
Proc Natl Acad Sci U S A 101:10332-7. 2004..These data describe a physiological situation under which conversion of TRalpha from apo-receptors into holo-receptors, upon changes in T3 availability, plays a determinant role in a developmental process...
- NFATc3 regulates Kv2.1 expression in arterial smooth muscleGregory C Amberg
Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 279:47326-34. 2004..1 expression and reduced IKv function. These results support the novel concept that NFATc3 controls the excitability of arterial smooth muscle by regulating Kv2.1 expression...
- Effects of hyperthyroidism on delayed rectifier K+ currents in left and right murine atriaYing Hu
Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0618, USA
Am J Physiol Heart Circ Physiol 289:H1448-55. 2005..the left atrium, which can contribute to the propensity for atrial arrhythmia in hyperthyroid heart...
- Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modelingNatalia A Tamarina
Dept of Medicine, University of Chicago, IL 60637, USA
Am J Physiol Endocrinol Metab 289:E578-85. 2005..The results underscore the importance of K(V)2.1 channel in repolarization of the pancreatic beta-cell plasma membrane and its role in regulating insulin secretion...
- Defining the dopamine transporter proteome by convergent biochemical and in silico analysesR Maiya
Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
Genes Brain Behav 6:97-106. 2007..In summary, this study identified a network of proteins that are primary candidates for functional regulation of the DAT, an important player in mechanisms of mental disorders and drug addiction...
- Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretionDavid A Jacobson
Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
Cell Metab 6:229-35. 2007..These results reveal the specific role of Kv2.1 in modulating glucose-stimulated APs of beta cells, exposing additional important currents involved in regulating physiological insulin secretion...
- Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytesE Miles Whitman
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Physiol Lung Cell Mol Physiol 294:L309-18. 2008..These results suggest that the inhibition of K(v) channel expression and rise in [Ca(2+)](i) during chronic hypoxia may be the result of HIF-1-dependent induction of ET-1...
- Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cellsF Lesage
Institut de Pharmacologie Moleculaire et Cellulaire, Valbonne, France
FEBS Lett 310:162-6. 1992..The message for the very peculiar K+ channel of IsK type could only be detected by polymerase chain reaction on skeletal muscle mRNA...
- IMAGING BETA CELL FUNCTION WITH BIOSENSORSLouis Philipson; Fiscal Year: 2007..The studies will provide new understanding of islet cell biology that will benefit clinical strategies to preserve and maintain functional 13-cell mass. ..