Kcnb1

Summary

Gene Symbol: Kcnb1
Description: potassium voltage gated channel, Shab-related subfamily, member 1
Alias: Kcr1-1, Kv2.1, Shab, potassium voltage-gated channel subfamily B member 1, voltage-gated potassium channel subunit Kv2.1
Species: mouse

Top Publications

  1. pmc Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons
    Hannah I Bishop
    Department of Neurobiology, Physiology and Behavior and
    J Neurosci 35:14922-42. 2015
  2. pmc AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes
    Marjaana A Peltola
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    Schizophr Bull 42:191-201. 2016
  3. pmc Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes
    Madeline Nieves-Cintrón
    From the Department of Pharmacology, University of California, Davis, California 95616
    J Biol Chem 290:7918-29. 2015
  4. doi Partial blockade of Kv2.1 channel potentiates GLP-1's insulinotropic effects in islets and reduces its dose required for improving glucose tolerance in type 2 diabetic male mice
    Rauza Sukma Rita
    Division of Integrative Physiology R S R, K D, T K, T Y, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan Department of Internal Medicine M K, Saitama Medical Center, Jichi Medical University School of Medicine, Saitama 337 8503, Japan and Department of Development Physiology T Y, Division of Adaptation Development, National Institute for Physiological Sciences, Okazaki, Aichi 444 8585, Japan
    Endocrinology 156:114-23. 2015
  5. pmc High temperature sensitivity is intrinsic to voltage-gated potassium channels
    Fan Yang
    Department of Physiology and Membrane Biology, University of California, Davis School of Medicine, Davis, United States
    elife 3:e03255. 2014
  6. pmc Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors
    Danielle Mandikian
    Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, 95616
    J Comp Neurol 522:3555-74. 2014
  7. pmc Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability
    D J Speca
    Department of Neurobiology, Physiology and Behavior, College of Biological Sciences
    Genes Brain Behav 13:394-408. 2014
  8. pmc AMIGO is an auxiliary subunit of the Kv2.1 potassium channel
    Marjaana A Peltola
    Neuroscience Center, University of Helsinki, PO Box 56, Helsinki FI 00014, Finland
    EMBO Rep 12:1293-9. 2011
  9. doi The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets
    Xiaoyan Nina Li
    Department of Metabolic Disorders, Merck Research Laboratories, Rahway, New Jersey, USA
    J Pharmacol Exp Ther 344:407-16. 2013
  10. ncbi Biochemical characterization of the native Kv2.1 potassium channel
    Jean Ju Chung
    Department of Neuroscience and High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    FEBS J 272:3743-55. 2005

Research Grants

  1. IMAGING BETA CELL FUNCTION WITH BIOSENSORS
    Louis Philipson; Fiscal Year: 2007

Scientific Experts

  • Eleazar Carmelo Vega-Saenz de Miera
  • Louis Philipson
  • David A Jacobson
  • Marjaana A Peltola
  • Elke Bocksteins
  • Hannah I Bishop
  • Rauza Sukma Rita
  • Madeline Nieves-Cintrón
  • James S Trimmer
  • Laxmi Kumar Parajuli
  • Danielle Mandikian
  • D J Speca
  • Fan Yang
  • Sari E Lauri
  • Juha Kuja-Panula
  • Tomi Taira
  • Heikki Rauvala
  • Xiaoyan Nina Li
  • Xilong Wu
  • X Q Dai
  • Kiril L Hristov
  • Xinyang Hu
  • Kwan Yi Chu
  • Takashi Ito
  • Xin Zhou
  • Shan Ping Yu
  • Manuel F Navedo
  • Ling Wei
  • Laskaro Zagoraiou
  • Anna N Bukiya
  • Jian Feng Wei
  • E Miles Whitman
  • R Maiya
  • J M Nerbonne
  • Ying Hu
  • Jean Ju Chung
  • Natalia A Tamarina
  • Wilfried Mai
  • Gregory C Amberg
  • Jun Zhou
  • Tero Hiekkalinna
  • Natalia Kulesskaya
  • Vootele Voikar
  • Johanna Liuhanen
  • Tiina Paunio
  • Petteri Piepponen
  • Jaana Suvisaari
  • Dongxu Guan
  • John D Scott
  • Karen Zito
  • Kenneth Johnson
  • Matthew A Nystoriak
  • Maria Paz Prada
  • MARK L DELL'ACQUA
  • Melanie M Cobb
  • Toshihiko Yada
  • Tomoyuki Kurashina
  • Katsuya Dezaki
  • Masafumi Kakei
  • William Fayer
  • Hiroaki Misonou
  • ROBERT C FOEHRING
  • Karl D Murray
  • J T Sack
  • Oscar Cerda
  • H I Bishop
  • G Ogata
  • K L Campi
  • J W Hell
  • B C Trainor
  • E T Doisy
  • Ryuichi Shigemoto
  • S W Wiler
  • D Mandikian
  • K Eum
  • J S Trimmer
  • Jie Zheng
  • P A Schwartzkroin
  • M S Golub
  • L Matt
  • H Jurgen Wenzel
  • Bei B Zhang
  • Maria L Garcia
  • Aleksandr Petrov
  • Hans E Hohmeier
  • Gregory J Kaczorowski
  • Andrew D Howard
  • Berenice Hernández-Enríquez
  • Michelle Banas
  • Mette V Jensen

Detail Information

Publications39

  1. pmc Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons
    Hannah I Bishop
    Department of Neurobiology, Physiology and Behavior and
    J Neurosci 35:14922-42. 2015
    ..2 in intratelencephalic and pyramidal tract neurons of L5, indicating circuit-specific requirements for these Kv2 paralogs. Together, these results support distinct roles for these two Kv2 channel family members in mammalian cortex...
  2. pmc AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes
    Marjaana A Peltola
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    Schizophr Bull 42:191-201. 2016
    ..Concomitantly, we have detected an association of a rare, population-specific polymorphism of KV2.1 (KCNB1) with human schizophrenia in a genetic isolate enriched with schizophrenia...
  3. pmc Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes
    Madeline Nieves-Cintrón
    From the Department of Pharmacology, University of California, Davis, California 95616
    J Biol Chem 290:7918-29. 2015
    ..Together, our study supports the concept that transcriptional suppression of KV2.1 by activation of the AKAP150-CaN/NFATc3 signaling axis contributes to enhanced arterial tone during diabetes. ..
  4. doi Partial blockade of Kv2.1 channel potentiates GLP-1's insulinotropic effects in islets and reduces its dose required for improving glucose tolerance in type 2 diabetic male mice
    Rauza Sukma Rita
    Division of Integrative Physiology R S R, K D, T K, T Y, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan Department of Internal Medicine M K, Saitama Medical Center, Jichi Medical University School of Medicine, Saitama 337 8503, Japan and Department of Development Physiology T Y, Division of Adaptation Development, National Institute for Physiological Sciences, Okazaki, Aichi 444 8585, Japan
    Endocrinology 156:114-23. 2015
    ..1 channels dramatically raises insulinotropic potency of GLP-1-based drugs, which opens a new avenue to reduce their doses and associated adverse effects while achieving the same glycemic control in type 2 diabetes...
  5. pmc High temperature sensitivity is intrinsic to voltage-gated potassium channels
    Fan Yang
    Department of Physiology and Membrane Biology, University of California, Davis School of Medicine, Davis, United States
    elife 3:e03255. 2014
    ....
  6. pmc Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors
    Danielle Mandikian
    Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, 95616
    J Comp Neurol 522:3555-74. 2014
    ..1 to dynamically impact intrinsic excitability...
  7. pmc Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability
    D J Speca
    Department of Neurobiology, Physiology and Behavior, College of Biological Sciences
    Genes Brain Behav 13:394-408. 2014
    ..1(-/-) mice exhibit accelerated seizure progression. Together, these findings suggest homeostatic suppression of elevated neuronal activity by Kv2.1 plays a central role in regulating neuronal network function...
  8. pmc AMIGO is an auxiliary subunit of the Kv2.1 potassium channel
    Marjaana A Peltola
    Neuroscience Center, University of Helsinki, PO Box 56, Helsinki FI 00014, Finland
    EMBO Rep 12:1293-9. 2011
    ..In conclusion, our data indicate AMIGO as a function-modulating auxiliary subunit for Kv2.1 and thus provide new insights into regulation of neuronal excitability...
  9. doi The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets
    Xiaoyan Nina Li
    Department of Metabolic Disorders, Merck Research Laboratories, Rahway, New Jersey, USA
    J Pharmacol Exp Ther 344:407-16. 2013
    ..2 modulates somatostatin release in δ-cells. Development of selective Kv2.1 inhibitors without cross inhibition of Kv2.2 may provide new avenues to promote GSIS for the treatment of type 2 diabetes...
  10. ncbi Biochemical characterization of the native Kv2.1 potassium channel
    Jean Ju Chung
    Department of Neuroscience and High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    FEBS J 272:3743-55. 2005
    ..1 subunits but not homologous Kv2.2 subunits. The proteins precipitated by anti-Kv2.1 and their physiological relevance are of interest for further investigation...
  11. doi The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function
    X Q Dai
    Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada T6G 2E1
    Diabetologia 55:1709-20. 2012
    ..We hypothesised that this interaction mediates insulin secretion independently of Kv2.1 electrical function...
  12. pmc Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle
    Kiril L Hristov
    Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, 29208, USA
    Am J Physiol Cell Physiol 302:C1599-608. 2012
    ..These findings reveal that ScTx1-sensitive K(V)2-containing channels are key regulators of human DSM excitability and contractility and may represent new targets for pharmacological or genetic intervention for bladder dysfunction...
  13. pmc Molecular mechanisms underlying the apoptotic effect of KCNB1 K+ channel oxidation
    Xilong Wu
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neuroscience and Cell Biology, 683 Hoes Ln W, Piscataway, New Jersey 08854, USA
    J Biol Chem 288:4128-34. 2013
    Potassium (K(+)) channels are targets of reactive oxygen species in the aging nervous system. KCNB1 (formerly Kv2...
  14. ncbi Functional differences in Kv1.5 currents expressed in mammalian cell lines are due to the presence of endogenous Kv beta 2.1 subunits
    V N Uebele
    Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 271:2406-12. 1996
    ..1 subunit can alter Kv1.5 alpha subunit function, 2) beta subunits are not required for alpha subunit expression, and 3) endogenous beta subunits are expressed in heterologous expression systems used to study K+ channel function...
  15. pmc Formation of Kv2.1-FAK complex as a mechanism of FAK activation, cell polarization and enhanced motility
    Jian Feng Wei
    Key Laboratory of Combined Multi organ Transplantation of Ministry of Health China, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
    J Cell Physiol 217:544-57. 2008
    ..1 expression and co-localization of Kv2.1 and FAK significantly enhanced directional cell migration and wound closure. It is suggested that the Kv2.1 channel may function as a promoting signal for FAK activation and cell motility...
  16. pmc Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activation
    Xinyang Hu
    Department of Cardiology, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China
    Am J Physiol Cell Physiol 301:C362-72. 2011
    ..These findings provide novel evidence that HP enhances the ability of BMSCs to migrate and home to the injured region; this effect is mediated through a regulatory role of Kv2.1 on FAK phosphorylation/activation...
  17. pmc Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses
    David A Jacobson
    Deparment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232 0615, USA
    J Physiol 588:3525-37. 2010
    ..8-fold with apamin. These results uncover important repolarizing roles for both Kv and K(Ca) channels and identify distinct roles for SK channel activity in regulating calcium- versus sodium-dependent AP firing...
  18. doi Regulation of Kv2.1 phosphorylation in an animal model of anoxia
    Takashi Ito
    Department of Pharmacology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Neurobiol Dis 38:85-91. 2010
    ..These results suggest that Kv2.1 is tightly regulated in a clinically relevant animal model of anoxia and further implicate its role in the homeostasis of neurons during anoxic stress...
  19. pmc A cluster of cholinergic premotor interneurons modulates mouse locomotor activity
    Laskaro Zagoraiou
    Howard Hughes Medical Institute, Kavli Institute for Brain Science, Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Neuron 64:645-62. 2009
    ..Thus, V0(C) interneurons represent a defined class of spinal cholinergic interneurons with an intrinsic neuromodulatory role in the control of locomotor behavior...
  20. doi Angiotensin II exerts glucose-dependent effects on Kv currents in mouse pancreatic beta-cells via angiotensin II type 2 receptors
    Kwan Yi Chu
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Am J Physiol Cell Physiol 298:C313-23. 2010
    ..These data suggest that hyperglycemia alters beta-cell function through modification of the K(v) channel which may be associated with the RAS...
  21. pmc The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constriction
    Anna N Bukiya
    The University of Tennessee Health Science Center, College of Medicine, Department of Pharmacology, Memphis, TN 38163, USA
    FEBS Lett 583:2779-84. 2009
    ..Knocking-down KCNMB1 suppresses EtOH-reduction of arterial myocyte BK current and vessel diameter. Therefore, BK beta(1) is the molecular effector of alcohol-induced BK current inhibition and cerebrovascular constriction...
  22. ncbi Modification of Kv2.1 K+ currents by the silent Kv10 subunits
    Eleazar Carmelo Vega-Saenz de Miera
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Brain Res Mol Brain Res 123:91-103. 2004
    ..The gene that encodes for Kv10.1 mRNAs maps to chromosome 2p22.1 in human, 6q12 in rat and 17E4 in mouse, locations consistent with the known systeny for human, rat and mouse chromosomes...
  23. ncbi A mouse brain homolog of the Drosophila Shab K+ channel with conserved delayed-rectifier properties
    M D Pak
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110
    J Neurosci 11:869-80. 1991
    We have cloned and expressed a mouse brain K+ channel that is the homolog of the Drosophila Shab K+ channel...
  24. ncbi K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse
    A Wei
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110
    Science 248:599-603. 1990
    The Drosophila Shaker gene on the X chromosome has three sister genes, Shal, Shab, and Shaw, which map to the second and third chromosomes...
  25. ncbi Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1, Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal imprinting region of mouse chromosome 2 are not monoallelically expressed
    C M Williamson
    MRC Radiobiology Unit, Didcot, Oxon, UK
    Genet Res 65:83-93. 1995
    ..that express transcription factors, 2 genes (Cyp24 and Pck1) that are involved in growth, 5 genes (Acra4, Edn3, Kcnb1, Mc3r and Ntsr) where a defect could lead to neurological and probably behavioural problems, and 3 genes (Cd40, ..
  26. ncbi Expression and function of pancreatic beta-cell delayed rectifier K+ channels. Role in stimulus-secretion coupling
    M W Roe
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 271:32241-6. 1996
    ..These studies implicate previously uncharacterized beta-cell delayed rectifier K+ channels in the regulation of membrane repolarization, [Ca2+]i, and insulin secretion...
  27. ncbi Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferation
    A Sobko
    Neurobiology Department, Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 18:10398-408. 1998
    ..Here, we show that a large repertoire of K+ channel alpha subunits of the Shaker (Kv1.1, Kv1.2, Kv1.4, and Kv1.5), Shab (Kv2.1), and Shaw (Kv3.1b and Kv3.2) families is expressed in mouse SCs and sciatic nerve...
  28. ncbi Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunit
    H Xu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Circ Res 85:623-33. 1999
    ..In vivo telemetric recordings also reveal marked QT prolongation, consistent with a defect in ventricular repolarization, in Kv2.1N216FLAG-expressing transgenic mice...
  29. ncbi Identification of two chromosomal loci determining glucose intolerance in a C57BL/6 mouse strain
    T Kayo
    Department of Hygiene, Akita University School of Medicine, Japan
    Comp Med 50:296-302. 2000
    ..05) at 10, 20, and 30 minutes during the intraperitoneal glucose tolerance test (IPGTT: 1.5 g glucose/kg of body weight)...
  30. ncbi Regional upregulation of Kv2.1-encoded current, IK,slow2, in Kv1DN mice is abolished by crossbreeding with Kv2DN mice
    Jun Zhou
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Heart Circ Physiol 284:H491-500. 2003
    ..1 polypeptide (Kv2DN) eliminated I(K,slow2). In summary, our data indicate that the spatially restrictive upregulation of Kv2.1-encoded currents underlies the increased dispersion of the repolarization observed in Kv1DN mice...
  31. pmc Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons
    Elke Bocksteins
    Laboratory for Molecular Biophysics, Physiology and Pharmacology, Department of Biomedical Sciences, University of Antwerp, Antwerpen 2610, Belgium
    Am J Physiol Cell Physiol 296:C1271-8. 2009
    ..1 channels, whereas the other component represents heterotetrameric K(v)2.1/silent K(v) channels. These observations support a physiological role for silent K(v) subunits in small DRG neurons...
  32. pmc Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life
    Wilfried Mai
    Animage Rhône Alpes Genopole, Unite Mixte de Recherche, Centre National de la Recherche Scientifique 5515, 59 Boulevard Pinel, 69003 Lyon, France
    Proc Natl Acad Sci U S A 101:10332-7. 2004
    ..These data describe a physiological situation under which conversion of TRalpha from apo-receptors into holo-receptors, upon changes in T3 availability, plays a determinant role in a developmental process...
  33. ncbi NFATc3 regulates Kv2.1 expression in arterial smooth muscle
    Gregory C Amberg
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 279:47326-34. 2004
    ..1 expression and reduced IKv function. These results support the novel concept that NFATc3 controls the excitability of arterial smooth muscle by regulating Kv2.1 expression...
  34. ncbi Effects of hyperthyroidism on delayed rectifier K+ currents in left and right murine atria
    Ying Hu
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0618, USA
    Am J Physiol Heart Circ Physiol 289:H1448-55. 2005
    ..the left atrium, which can contribute to the propensity for atrial arrhythmia in hyperthyroid heart...
  35. ncbi Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling
    Natalia A Tamarina
    Dept of Medicine, University of Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 289:E578-85. 2005
    ..The results underscore the importance of K(V)2.1 channel in repolarization of the pancreatic beta-cell plasma membrane and its role in regulating insulin secretion...
  36. ncbi Defining the dopamine transporter proteome by convergent biochemical and in silico analyses
    R Maiya
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Genes Brain Behav 6:97-106. 2007
    ..In summary, this study identified a network of proteins that are primary candidates for functional regulation of the DAT, an important player in mechanisms of mental disorders and drug addiction...
  37. pmc Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion
    David A Jacobson
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Cell Metab 6:229-35. 2007
    ..These results reveal the specific role of Kv2.1 in modulating glucose-stimulated APs of beta cells, exposing additional important currents involved in regulating physiological insulin secretion...
  38. ncbi Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes
    E Miles Whitman
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 294:L309-18. 2008
    ..These results suggest that the inhibition of K(v) channel expression and rise in [Ca(2+)](i) during chronic hypoxia may be the result of HIF-1-dependent induction of ET-1...
  39. ncbi Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells
    F Lesage
    Institut de Pharmacologie Moleculaire et Cellulaire, Valbonne, France
    FEBS Lett 310:162-6. 1992
    ..The message for the very peculiar K+ channel of IsK type could only be detected by polymerase chain reaction on skeletal muscle mRNA...

Research Grants1

  1. IMAGING BETA CELL FUNCTION WITH BIOSENSORS
    Louis Philipson; Fiscal Year: 2007
    ..The studies will provide new understanding of islet cell biology that will benefit clinical strategies to preserve and maintain functional 13-cell mass. ..