Kcnj11

Summary

Gene Symbol: Kcnj11
Description: potassium inwardly rectifying channel, subfamily J, member 11
Alias: Kir6.2, mBIR, ATP-sensitive inward rectifier potassium channel 11, inward rectifier K(+) channel Kir6.2
Species: mouse

Top Publications

  1. ncbi Characterization of the mouse sulfonylurea receptor 1 promoter and its regulation
    C Hernandez-Sanchez
    Section on Molecular and Cellular Physiology, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1770, USA
    J Biol Chem 274:18261-70. 1999
  2. ncbi Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility
    Takashi Miki
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 54:1056-63. 2005
  3. pmc Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:18214-9. 2006
  4. ncbi Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor
    N Inagaki
    Division of Molecular Medicine, Chiba University School of Medicine, Japan
    Science 270:1166-70. 1995
  5. ncbi Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle
    H Sakura
    University Laboratory of Physiology, Oxford, UK
    FEBS Lett 377:338-44. 1995
  6. ncbi A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels
    N Inagaki
    Division of Molecular Medicine Center for Biomedical Science, Chiba University School of Medicine, Chuo Ku, Chiba 260, Japan
    Neuron 16:1011-7. 1996
  7. pmc Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel
    M Yamada
    Department of Pharmacology II, Faculty of Medicine, Osaka University, Japan
    J Physiol 499:715-20. 1997
  8. ncbi Localization of the ATP-sensitive K+ channel subunit Kir6.2 in mouse pancreas
    M Suzuki
    Laboratory of Molecular and Cellular Morphology, Institute for Molecular and Cellular Regulation, Gunma University, Japan
    Diabetes 46:1440-4. 1997
  9. pmc Evidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel
    E Lorenz
    Department of Medicine, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA
    Mol Cell Biol 18:1652-9. 1998
  10. pmc Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice
    T Miki
    Department of Molecular Medicine, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chuo Ku, Chiba 260, Japan
    Proc Natl Acad Sci U S A 95:10402-6. 1998

Scientific Experts

  • S Seino
  • Gang Hu
  • Shampa Chatterjee
  • B Breant
  • Alexey E Alekseev
  • Harley T Kurata
  • Lusha Xiang
  • H Dobrzynski
  • Olga Jilkina
  • Maria Remedi
  • Patrick E MacDonald
  • Tong Lu
  • Thomas P Flagg
  • P E Squires
  • Yutaka Oiso
  • Jinfang Zhu
  • Yoshitaka Oyamada
  • R M Deacon
  • M Suzuki
  • Takashi Miki
  • T Miki
  • Andre Terzic
  • Frances M Ashcroft
  • Garvan C Kane
  • Shozeb Haider
  • Aron B Fisher
  • Kohtaro Minami
  • Satsuki Yamada
  • Mark S P Sansom
  • Richard J Gumina
  • Tatyana Milovanova
  • Crystal F Kline
  • Xiao Ke Liu
  • William A Coetzee
  • Scott A John
  • Denice M Hodgson
  • Chiyo Shiota
  • Tim J Craig
  • Hua Qian Yang
  • Peter Proks
  • Birgit Liss
  • Colin G Nichols
  • Kris Debolt
  • Andrei I Tarasov
  • Jean Marc Renaud
  • Zhong Wei Yang
  • Piyali Dhar-Chowdhury
  • Atta Behfar
  • Andrew P Wojtovich
  • Jenny B W Li
  • Qunwei Zhang
  • Ikuo Matsuzaki
  • Julia Schiemann
  • Qadeer Aziz
  • Peter J Mohler
  • Mark E Anderson
  • Thomas J Hund
  • Darko Pucar
  • Xuehui Geng
  • B Valtat
  • Mayrin C Medina
  • R K P Benninger
  • Dong Kong
  • N Inagaki
  • Jingdong Li
  • Jeremy D Bushman
  • Jens C Bruning
  • Petras P Dzeja
  • D Kent Arrell
  • Magalie A Ravier
  • Timothy J Nelson
  • W Fujimoto
  • Christophe A Girard
  • Jochen Roeper
  • A Puddu
  • Xinli Hu
  • Jin Xu
  • Xue Ru Shi
  • Carlo Cifelli
  • Julien P Dupuis
  • Koichi Fukuzaki
  • Jean Revilloud
  • Michel Vivaudou
  • S Reyes
  • Ricard Masia
  • Eric Hosy
  • H S Sun
  • Jonni S Moore
  • Jun Yup Jin
  • Muniswamy Madesh

Detail Information

Publications104 found, 100 shown here

  1. ncbi Characterization of the mouse sulfonylurea receptor 1 promoter and its regulation
    C Hernandez-Sanchez
    Section on Molecular and Cellular Physiology, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1770, USA
    J Biol Chem 274:18261-70. 1999
    ..2 genes since glucocorticoids failed to affect the stability of each mRNA. Likewise, the reduction in mRNA levels was correlated with a decrease in SUR1 and Kir6.2 protein levels...
  2. ncbi Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility
    Takashi Miki
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 54:1056-63. 2005
    ..Although both GIP and GLP-1 increase the intracellular cAMP concentration and potentiate insulin secretion, these results demonstrate that the GLP-1 and GIP signaling pathways involve the K(ATP) channel differently...
  3. pmc Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:18214-9. 2006
    ..Reduced Th2 cell expansion in the absence of Gfi-1 was confirmed by the diminished frequency of IL-4-producing cells when these mice were infected with Schistosoma mansoni...
  4. ncbi Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor
    N Inagaki
    Division of Molecular Medicine, Chiba University School of Medicine, Japan
    Science 270:1166-70. 1995
    ..Gene mapping data show that these two potassium channel subunit genes are clustered on human chromosome 11 at position 11p15.1...
  5. ncbi Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle
    H Sakura
    University Laboratory of Physiology, Oxford, UK
    FEBS Lett 377:338-44. 1995
    ..Single-channel activity was voltage-independent and was blocked by 1 mM intracellular ATP or 0.5 mM tolbutamide. We conclude that the Kir6.2/SUR channel complex comprises the ATP-sensitive K-channel...
  6. ncbi A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels
    N Inagaki
    Division of Molecular Medicine Center for Biomedical Science, Chiba University School of Medicine, Chuo Ku, Chiba 260, Japan
    Neuron 16:1011-7. 1996
    ..The present study shows that the ATP sensitivity and pharmacological properties of K(ATP) channels are determined by a family of structurally related but functionally distinct sulfonylurea receptors...
  7. pmc Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel
    M Yamada
    Department of Pharmacology II, Faculty of Medicine, Osaka University, Japan
    J Physiol 499:715-20. 1997
    ..5. Therefore, the K+ channel composed of SUR2B and Kir6.1 is not a classical ATP-sensitive K+ channel but closely resembles the nucleotide diphosphate-dependent K+ channel in vascular smooth muscle cells...
  8. ncbi Localization of the ATP-sensitive K+ channel subunit Kir6.2 in mouse pancreas
    M Suzuki
    Laboratory of Molecular and Cellular Morphology, Institute for Molecular and Cellular Regulation, Gunma University, Japan
    Diabetes 46:1440-4. 1997
    ..2 is at the plasma membrane of islet cells. These results suggest that Kir6.2, as a component of K(ATP) channels, is an important molecule in the regulation of all the release of insulin, glucagon, and somatostatin...
  9. pmc Evidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel
    E Lorenz
    Department of Medicine, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA
    Mol Cell Biol 18:1652-9. 1998
    ..This study provides direct evidence that an inwardly rectifying K+ channel and an ATP-binding cassette protein physically associate, which affects the cellular distribution and kinetic behavior of a KATP channel...
  10. pmc Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice
    T Miki
    Department of Molecular Medicine, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chuo Ku, Chiba 260, Japan
    Proc Natl Acad Sci U S A 95:10402-6. 1998
    ....
  11. pmc Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons
    B Liss
    Institute for Neural Signal Transduction, Centre for Molecular Neurobiology, Martinistrasse 52, 20246 Hamburg, Germany
    EMBO J 18:833-46. 1999
    ....
  12. ncbi A K(ATP) channel deficiency affects resting tension, not contractile force, during fatigue in skeletal muscle
    B Gong
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
    Am J Physiol Cell Physiol 279:C1351-8. 2000
    ..It is also suggested that the K(ATP) channel plays an important role in protecting muscle function in older mice...
  13. ncbi Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice
    M Suzuki
    Department of Pharmacology, Chiba University School of Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Circ Res 88:570-7. 2001
    ..1 mRNA was expressed. These findings indicate that the Kir6.2 subunit mediates the depression of cardiac excitability and contractility induced by KCOs; in contrast, Kir6.2 plays no discernible role in the arterial tree...
  14. ncbi ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis
    T Miki
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Nat Neurosci 4:507-12. 2001
    ..Thus, our results demonstrate that KATP channels are important in glucose sensing in VMH GR neurons, and are essential for the maintenance of glucose homeostasis...
  15. ncbi Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure
    K Yamada
    Department of Physiology, Akita University School of Medicine, Hondo, Akita 010 8543, Japan
    Science 292:1543-6. 2001
    ..K(ATP) channels exert a depressant effect on SNr neuronal activity during hypoxia and may be involved in the nigral protection mechanism against generalized seizures...
  16. pmc Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice
    Masashi Suzuki
    Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba, Japan
    J Clin Invest 109:509-16. 2002
    ..The rapid heart rate of the mouse (>600 beats per minute) may magnify the relative importance of sarcK(ATP) channels during ischemia, prompting caution in the extrapolation of the conclusions to larger mammals...
  17. pmc Kir6.2 is required for adaptation to stress
    Leonid V Zingman
    Division of Cardiovascular Diseases, Departments of Medicine and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 99:13278-83. 2002
    ..In the absence of Kir6.2, vigorous sympathetic challenge caused arrhythmia and sudden death, preventable by calcium-channel blockade. Thus, this vital function identifies a physiological role for K(ATP) channels in the heart...
  18. ncbi Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics
    Richard J Gumina
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 284:H2106-13. 2003
    ..Thus intact K(ATP) channels are integral in ischemic preconditioning-induced protection of cellular energetic dynamics and associated cardiac performance...
  19. pmc Identification of residues contributing to the ATP binding site of Kir6.2
    Stefan Trapp
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    EMBO J 22:2903-12. 2003
    ..These results support the idea that K185 interacts with the beta-phosphate of ATP. Thus both N- and C-termini may contribute to the ATP binding site...
  20. pmc Molecular mechanism for ATP-dependent closure of the K+ channel Kir6.2
    Scott A John
    UCLA Cardiovascular Research Laboratory, Department of Physiology, UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Physiol 552:23-34. 2003
    ..Binding of the alpha phosphate group of ATP to R201 then stabilizes the closed state. R50 on the N-terminus controls ATP binding by facilitating the interaction of the beta phosphate group of ATP with K185 to destabilize the open state...
  21. ncbi A gene-driven ENU-based approach to generating an allelic series in any gene
    Mohamed Mohideen Quwailid
    MRC Mammalian Genetics Unit, Medical Research Council, OX11 0RD, Harwell, Oxfordshire, UK
    Mamm Genome 15:585-91. 2004
    ..It is now available to academic collaborators as a community resource...
  22. ncbi Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K+ channel, predisposes to catecholamine-induced ventricular dysrhythmia
    Xiao Ke Liu
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Diabetes 53:S165-8. 2004
    ..Thus, intact KATP channel function is mandatory for adequate repolarization under sympathetic stress providing electrical tolerance against triggered arrhythmia...
  23. ncbi Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor
    Chiyo Shiota
    Vanderbilt University School of Medicine, Dept of Molecular Physiology and Biophysics, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 289:E570-7. 2005
    ..These findings indicate that K(ATP) channels in alpha-cells play a key role in regulating glucagon secretion, thereby adding to the paradox of how mice that lack K(ATP) channels maintain euglycemia...
  24. ncbi K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons
    Birgit Liss
    Molecular Neurobiology, Department of Physiology, Marburg University Deutschhausstrasse 2, 35037 Marburg, Germany
    Nat Neurosci 8:1742-51. 2005
    ..Thus, K-ATP channel activation has an unexpected role in promoting death of DA neurons in chronic disease...
  25. pmc 3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1
    Michael V Mikhailov
    Laboratory of Physiology, University of Oxford, Oxford, UK
    EMBO J 24:4166-75. 2005
    ..2. The nucleotide-binding domains of adjacent SUR1 appear to interact, and form a large docking platform for cytosolic proteins. The structure, in combination with molecular modelling, suggests how SUR1 interacts with Kir6.2...
  26. pmc Consequences of cardiac myocyte-specific ablation of KATP channels in transgenic mice expressing dominant negative Kir6 subunits
    Xiaoyong Tong
    Pediatric Cardiology, NYU School of Medicine, 560 First Ave, TCH 521, New York, NY 10016, USA
    Am J Physiol Heart Circ Physiol 291:H543-51. 2006
    ....
  27. ncbi KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure in hypertension
    Garvan C Kane
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Hum Mol Genet 15:2285-97. 2006
    ..Here in experimental hypertension, knockout of the KCNJ11 gene, encoding the Kir6...
  28. pmc Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant
    Satsuki Yamada
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 577:1053-65. 2006
    ..Thus, K(ATP) channels appear mandatory in acute and chronic cardiac adaptation to imposed haemodynamic load, protecting against congestive heart failure and death...
  29. pmc A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans
    Patrick E MacDonald
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
    PLoS Biol 5:e143. 2007
    ..We propose that elevated glucose reduces electrical activity and exocytosis via depolarisation-induced inactivation of ion channels involved in action potential firing and secretion...
  30. pmc Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes
    Christophe A Girard
    Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    J Clin Invest 119:80-90. 2009
    ..2, SUR1, and insulin mRNA. All these changes are expected to contribute to the diabetes of beta-V59M mice. Their cause requires further investigation...
  31. pmc ATP-sensitive K+ channel knockout induces cardiac proteome remodeling predictive of heart disease susceptibility
    D Kent Arrell
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Proteome Res 8:4823-34. 2009
    ..Proteomic cartography thus provides an integral view of molecular remodeling in the heart induced by K(ATP) channel deletion, establishing a systems approach that predicts outcome at a presymptomatic stage...
  32. pmc Sarcolemmal ATP-sensitive K(+) channels control energy expenditure determining body weight
    Alexey E Alekseev
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Cell Metab 11:58-69. 2010
    ....
  33. pmc Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning
    Andrew P Wojtovich
    Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Am J Physiol Heart Circ Physiol 304:H1439-45. 2013
    ..2(-/-) mice, suggesting no role for Kir6.2 in the mKATP. Collectively, these data indicate that Kir6.2 is required for the full response to IPC or diazoxide but is not involved in mKATP formation...
  34. pmc Role of Kir6.2 subunits of ATP-sensitive potassium channels in endotoxemia-induced cardiac dysfunction
    Zhong Wei Yang
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
    Cardiovasc Diabetol 12:75. 2013
    ..ATP-sensitive potassium (KATP) channels are critical to cardiac function. This study investigates the role of Kir6.2 subunits of KATP channels on cardiac dysfunction in lipopolysaccharide (LPS)-induced endotoxemia...
  35. ncbi ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits
    Garvan C Kane
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Diabetes 53:S169-75. 2004
    ..Thus, Kir6.2-containing K(ATP) channel activity is required for attainment of the physiologic benefits of exercise training without injury...
  36. pmc Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit
    Jennifer F Antcliff
    University Laboratory of Physiology, Parks Road, Oxford, UK
    EMBO J 24:229-39. 2005
    ..Consistent with a role in gating, mutations in the slide helix bias the intrinsic channel conformation towards the open state...
  37. pmc Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating
    Shozeb Haider
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    Biophys J 88:3310-20. 2005
    ..It is of interest that loss of exact rotational symmetry has also been suggested to play a role in gating in the bacterial Kir homolog, KirBac1.1, and in the nicotinic acetylcholine receptor channel...
  38. ncbi Long chain coenzyme A esters activate the pore-forming subunit (Kir6. 2) of the ATP-regulated potassium channel
    R Branstrom
    Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institute, S 171 76 Stockholm, Sweden
    J Biol Chem 273:31395-400. 1998
    ..2 is the primary target for LC-CoA esters to activate the KATP channel and that the esters are likely to induce a conformational change by a direct interference with the pore-forming subunit, leading to openings of long duration...
  39. ncbi Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose
    Chiyo Shiota
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:37176-83. 2002
    ....
  40. ncbi Protection against hypoxic-ischemic injury in transgenic mice overexpressing Kir6.2 channel pore in forebrain
    Lisa Heron-Milhavet
    National Institutes of Health, Diabetes Branch, NIDDK, Bethesda, MD 20892 1758, USA
    Mol Cell Neurosci 25:585-93. 2004
    ..Taken together, these results indicate that the transgenic overexpression of Kir6.2 in forebrain significantly protects mice from hypoxic-ischemic injury and neuronal damage seen in stroke...
  41. ncbi Activation of endothelial NADPH oxidase during normoxic lung ischemia is KATP channel dependent
    Qunwei Zhang
    Inst for Environmental Medicine, University of Pennsylvania School of Medicine, 1 John Morgan Bldg, 3620 Hamilton Walk, Philadelphia, PA 19104 6068, USA
    Am J Physiol Lung Cell Mol Physiol 289:L954-61. 2005
    ..Thus membrane depolarization during lung ischemia requires the presence of a K(ATP) channel and is required for activation of NADPH oxidase and endothelial ROS generation...
  42. ncbi KATP channels are an important component of the shear-sensing mechanism in the pulmonary microvasculature
    S Chatterjee
    Institute for Environmental Medicine, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 6068, USA
    Microcirculation 13:633-44. 2006
    ..To investigate the role of a KATP channel in sensing shear, specifically its cessation, in the endothelial cells of the pulmonary microvasculature...
  43. doi Caveolin-1 is essential for glimepiride-induced insulin secretion in the pancreatic betaTC-6 cell line
    A Puddu
    Department of Internal Medicine, University of Genova, Genova, Italy
    Biochem Biophys Res Commun 375:235-7. 2008
    ..Moreover, we find a direct interaction between caveolin-1 and Kir6.2, one of the K(ATP) channel subunit. These results demonstrate that Cav-1 plays a critical role for glucose and sulfonylurea-stimulated insulin secretion...
  44. pmc Adipocyte-derived factor reduces vasodilatory capability in ob-/ob- mice
    Lusha Xiang
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol Heart Circ Physiol 297:H689-95. 2009
    ..The absolute diameters induced by muscle stimulation were not altered by the fat-conditioned PSS. These results suggest that, in ob mice, local ADFs reduce the functional vasodilatory capability via opening K(ATP) channels...
  45. pmc Characterization and functional restoration of a potassium channel Kir6.2 pore mutation identified in congenital hyperinsulinism
    Jeremy D Bushman
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 285:6012-23. 2010
    ..We conclude that the glycine at 156 is not essential for K(ATP) channel gating and that the Kir6.2 gating defect caused by the G156R mutation could be rescued by manipulating chemical interactions between pore residues...
  46. pmc K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration
    Julia Schiemann
    Institute of Neurophysiology, Neuroscience Center, Goethe University, Frankfurt, Germany
    Nat Neurosci 15:1272-80. 2012
    ....
  47. pmc Decomposition of slide helix contributions to ATP-dependent inhibition of Kir6.2 channels
    Jenny B W Li
    Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 288:23038-49. 2013
    ..These findings reveal unrecognized slide helix elements that are required for functional channel expression and control of Kir6.2 gating by intracellular ATP. ..
  48. pmc βIV-Spectrin and CaMKII facilitate Kir6.2 regulation in pancreatic beta cells
    Crystal F Kline
    Dorothy M Davis Heart and Lung Research Institute, Department of Molecular and Cellular Biochemistry, Division of Cardiovascular Medicine, Department of Internal Medicine, and Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH 43210
    Proc Natl Acad Sci U S A 110:17576-81. 2013
    ....
  49. pmc Plasticity of sarcolemmal KATP channel surface expression: relevance during ischemia and ischemic preconditioning
    Hua Qian Yang
    Pediatrics
    Am J Physiol Heart Circ Physiol 310:H1558-66. 2016
    ..Our data demonstrate that plasticity of KATP channel surface expression must be considered as a potentially important mechanism of the protective effects of IPC and adenosine. ..
  50. pmc ATP sensitivity of ATP-sensitive K+ channels: role of the gamma phosphate group of ATP and the R50 residue of mouse Kir6.2
    Scott A John
    UCLA Cardiovascular Research Laboratory, Department of Medicine Cardiology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Physiol 568:931-40. 2005
    ..Based on these results, we propose that a phosphate group or a negative charge at position 50 initiates channel closure by destabilizing the electrostatic interactions between negative phosphate groups of PIP2 and residues such as R54...
  51. ncbi KATP channel-deficient pancreatic beta-cells are streptozotocin resistant because of lower GLUT2 activity
    Jin Xu
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada
    Am J Physiol Endocrinol Metab 294:E326-35. 2008
    ..2(-/-) mice are STZ resistant because of a decrease in STZ transport by GLUT2 in pancreatic beta-cells and 2) the decreased transport is due to a downregulation of GLUT2 activity involving an effect at the COOH terminus...
  52. pmc Three C-terminal residues from the sulphonylurea receptor contribute to the functional coupling between the K(ATP) channel subunits SUR2A and Kir6.2
    Julien P Dupuis
    Institut de Biologie Structurale, UMR5075 CEA CNRS University J Fourier, 41, rue Jules Horowitz, 38027 Grenoble, France
    J Physiol 586:3075-85. 2008
    ..These results indicate that, within the K(ATP) channel complex, the proximal C-terminal of SUR2A is a critical link between ligand binding to SUR2A and Kir6.2 up-regulation...
  53. pmc α-Synuclein binds the K(ATP) channel at insulin-secretory granules and inhibits insulin secretion
    Xuehui Geng
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Am J Physiol Endocrinol Metab 300:E276-86. 2011
    ..Synuclein might play similar roles in diabetes as it does in other degenerative diseases, including Alzheimer's and Parkinson's diseases...
  54. pmc Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C
    Qadeer Aziz
    William Harvey Heart Centre, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Biol Chem 287:6196-207. 2012
    ..2 (Ser-372) whose phosphorylation leads to down-regulation of the channel complex. This inhibitory effect is distinct from activation which is seen with low levels of channel activity...
  55. pmc Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel
    T Miki
    Division of Molecular Medicine, Center for Biomedical Science, Chiba University School of Medicine, Chuo Ku, Chiba 260, Japan
    Proc Natl Acad Sci U S A 94:11969-73. 1997
    ....
  56. ncbi ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissue
    Takashi Miki
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Research Center for Pathogenic Fungi and Microbial Toxicoses, and Gene Research Center, Chiba University, Chiba 260 8670, Japan
    Am J Physiol Endocrinol Metab 283:E1178-84. 2002
    ..2(-/-) and WT mice, suggesting that the increase in glucose uptake in Kir6.2(-/-) adipocytes is mediated by altered extracellular hormonal or neuronal signals altered by disruption of the K(ATP) channels...
  57. pmc Hyperinsulinism induced by targeted suppression of beta cell KATP channels
    J C Koster
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:16992-7. 2002
    ..The results suggest that incomplete suppression of K(ATP) channel activity can give rise to a maintained hyperinsulinism...
  58. ncbi K(ATP) channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetes
    Yoshiko Kanezaki
    Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima, Japan
    Endocr J 51:133-44. 2004
    ..Thus, the defects in glucose-induced insulin secretion (Kir6.2KO) and an insulin resistance in muscle and fat (hIR(KM)TG) were not sufficient to lead to overt diabetes...
  59. ncbi Membrane depolarization and NADPH oxidase activation in aortic endothelium during ischemia reflect altered mechanotransduction
    Ikuo Matsuzaki
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, 1 John Morgan Bldg, Philadelphia, PA 19104 6068, USA
    Am J Physiol Heart Circ Physiol 288:H336-43. 2005
    ....
  60. ncbi Roles of ATP-sensitive K+ channels as metabolic sensors: studies of Kir6.x null mice
    Kohtaro Minami
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes 53:S176-80. 2004
    ..Our studies of Kir6.2 null and Kir6.1 null mice reveal that KATP channels are critical metabolic sensors in acute metabolic changes, including hyperglycemia, hypoglycemia, ischemia, and hypoxia...
  61. ncbi Role of ATP-sensitive K+ channels in electrophysiological alterations during myocardial ischemia: a study using Kir6.2-null mice
    Tomoaki Saito
    Department of Pharmacology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Am J Physiol Heart Circ Physiol 288:H352-7. 2005
    ..2 KO hearts provides evidence that the activation of K(ATP) channels contributes to the shortening of APD, whereas it is not the primary cause of extracellular K(+) accumulation during early myocardial ischemia...
  62. ncbi Treadmill running causes significant fiber damage in skeletal muscle of KATP channel-deficient mice
    M Thabet
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Physiol Genomics 22:204-12. 2005
    ..2(-/-) diaphragm muscles compared with hindlimb muscles...
  63. ncbi Lung endothelial cell proliferation with decreased shear stress is mediated by reactive oxygen species
    Tatyana Milovanova
    Institute for Environmental Medicine, Univ of Pennsylvania Medical Center, One John Morgan Bldg, Philadelphia, PA 19104 6068, USA
    Am J Physiol Cell Physiol 290:C66-76. 2006
    ..Thus loss of shear stress in flow-adapted mPMVECs results in cell division associated with ROS generated by NADPH oxidase. This effect requires a functioning cell membrane KATP channel...
  64. pmc The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function
    Piyali Dhar-Chowdhury
    Department of Pediatrics, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 280:38464-70. 2005
    ..Our data are consistent with the concept that the activity of these enzymes (possibly by ATP formation in the immediate intracellular microenvironment of this macromolecular K(ATP) channel complex) causes channel closure...
  65. pmc Kir6.2 mutations causing neonatal diabetes prevent endocytosis of ATP-sensitive potassium channels
    Jamel Mankouri
    Institute of Membrane and Systems Biology, Faculty of Biological Sciences, Leeds University, Leeds, UK
    EMBO J 25:4142-51. 2006
    ..The data imply that endocytosis of KATP channels plays a crucial role in the (patho)-physiology of insulin secretion...
  66. ncbi ATP sensitivity of the ATP-sensitive K+ channel in intact and permeabilized pancreatic beta-cells
    Andrei I Tarasov
    University Laboratory of Physiology, Oxford University, Oxford, OX1 3PT, UK
    Diabetes 55:2446-54. 2006
    ..The ATP sensitivity observed in permeabilized cells accounts quantitatively for K(ATP) channel activity in intact cells. Thus, our results show that the principal metabolic regulators of K(ATP) channel activity are MgATP and MgADP...
  67. ncbi Kir6.2-containing ATP-sensitive potassium channels protect cortical neurons from ischemic/anoxic injury in vitro and in vivo
    H S Sun
    Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive Northwest, Calgary, Alberta, Canada T2N 4N1
    Neuroscience 144:1509-15. 2007
    ..2(-/-) OGD group. These findings suggest that stimulation of endogenous cortical K(ATP) channels may provide a useful strategy for limiting the damage that results from cerebral ischemic stroke...
  68. ncbi KATP channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart
    Richard J Gumina
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 292:H1706-13. 2007
    Gene knockout of the KCNJ11-encoded Kir6.2 ATP-sensitive K(+) (K(ATP)) channel implicates this stress-response element in the safeguard of cardiac homeostasis under imposed demand...
  69. ncbi Arrhythmia susceptibility and premature death in transgenic mice overexpressing both SUR1 and Kir6.2[DeltaN30,K185Q] in the heart
    Thomas P Flagg
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 293:H836-45. 2007
    ..2[DeltaN30,K185Q] in the myocardium specifically, the results highlight the critical differential activation of SUR1 versus SUR2A, and indicate that expression of hyperactive K(ATP) in the heart is likely to be proarrhythmic...
  70. pmc Remodelling of the SUR-Kir6.2 interface of the KATP channel upon ATP binding revealed by the conformational blocker rhodamine 123
    Eric Hosy
    Institute of Structural Biology, UMR5075 CEA CNRS University J Fourier, 41, rue Jules Horowitz, 38027 Grenoble, France
    J Physiol 582:27-39. 2007
    ..2 interface and that binding of ATP to SUR triggers a change in the structure of the contact zone between Kir6.2 and domain TMD0 of SUR that causes masking of the Rho123 site on Kir6.2...
  71. ncbi Uncoupling by (--)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP
    Jun Yup Jin
    Department of Physiology and Chronic Disease Research Center, Keimyung University School of Medicine, 194 Dongsan dong, Jung Gu, Daegu 700 712, Republic of Korea
    Pharmacol Res 56:237-47. 2007
    ..2. The specificity of EGCG possibly implies that 5'-OH of the B-ring on the pyrogallol moiety in the EGCG molecule may be critical for these actions of EGCG on the K(ATP) channel...
  72. pmc KATP channels confer survival advantage in cocaine overdose
    S Reyes
    Mol Psychiatry 12:1060-1. 2007
  73. doi Kir6.2 knockout alters neurotransmitter release in mouse striatum: an in vivo microdialysis study
    Xue Ru Shi
    Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, PR China
    Neurosci Lett 439:230-4. 2008
    ..Taken together, this study provides direct in vivo evidence that Kir6.2-containing K-ATP channels play regulatory roles in neurotransmitter release in the striatum...
  74. pmc Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress
    Tatyana Milovanova
    Institute for Environmental Medicine, University of Pennsylvania Medical Center, One John Morgan Building, Philadelphia, PA 19104 6068, USA
    Biochim Biophys Acta 1783:1866-75. 2008
    ..These studies indicate that caveolin-1 functions as a shear sensor in flow-adapted EC resulting in ROS-mediated cell signaling and endothelial cell proliferation following the abrupt reduction in flow...
  75. doi Contractile dysfunctions in ATP-dependent K+ channel-deficient mouse muscle during fatigue involve excessive depolarization and Ca2+ influx through L-type Ca2+ channels
    Carlo Cifelli
    University of Ottawa, Department of Cellular and Molecular Medicine, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5
    Exp Physiol 93:1126-38. 2008
    ..It is concluded that: (1) KATP channels are crucial in preventing excessive membrane depolarization and Ca2+ influx through L-type Ca2+ channels; and (2) they contribute to the decrease in force during fatigue...
  76. pmc How ATP inhibits the open K(ATP) channel
    Tim J Craig
    Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
    J Gen Physiol 132:131-44. 2008
    ..The data are inconsistent with a Hodgkin-Huxley model (four independent steps) or a dimer model (two independent dimers). When the channel is open, ATP binds to a single ATP-binding site with a dissociation constant of 300 microM...
  77. ncbi Regulation of KATP channel expression and activity by the SUR1 nucleotide binding fold 1
    Ricard Masia
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Channels (Austin) 1:315-23. 2007
    ....
  78. pmc Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload
    Xinli Hu
    Cardiovascular Division, Department of Medicine, Universityof Minnesota Medical School, Minneapolis, MN 55455, USA
    Circ Res 103:1009-17. 2008
    ..These data indicate that K(ATP) channels facilitate the cardiac response to stress by regulating PGC-1alpha and its target genes, at least partially through the FOXO1 pathway...
  79. pmc Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice
    W Fujimoto
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Japan
    Diabetologia 52:863-72. 2009
    ..2(-/-) mice [up-to-date symbol for Kir6.2 gene is Kcnj11]), in which glucose alone does not trigger insulin secretion...
  80. doi Defects in myoglobin oxygenation in K(ATP)-deficient mouse hearts under normal and stress conditions characterized by near infrared spectroscopy and imaging
    Olga Jilkina
    Institute for Biodiagnostics, National Research Council of Canada, Winnipeg, MB, Canada
    Int J Cardiol 149:315-22. 2011
    ..2-containing channels in the development of cardiac disease, we analysed the left ventricular (LV) wall oxygenation and the physiologic responses induced by acute stress in non-dilated Kir6.2(-/-) hearts...
  81. pmc Ankyrin-B regulates Kir6.2 membrane expression and function in heart
    Jingdong Li
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 285:28723-30. 2010
    ..Collectively, our new findings define a new role for cardiac ankyrin polypeptides in regulation of ion channel membrane expression in heart...
  82. doi Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice
    B Valtat
    INSERM UMR S 872, Centre de Recherche des Cordeliers, 15 rue de l Ecole de Medecine, 75006 Paris, France
    Diabetologia 54:350-9. 2011
    ..Our aim was to further dissect the role of glucocorticoids on beta cell development and function in mice...
  83. pmc Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis
    Dong Kong
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 12:545-52. 2010
    ..Combined, the glucose-excited neurons are likely to play key, previously unexpected roles in regulating blood glucose...
  84. pmc Defects in beta cell Ca²+ signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitus
    R K P Benninger
    Molecular Physiology and Biophysics, Vanderbilt University, 2215 Garland Avenue, Nashville, TN 37232, USA
    Diabetologia 54:1087-97. 2011
    ..We investigated whether defects in calcium signalling alone are sufficient to explain short-term and long-term islet dysfunction...
  85. pmc The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion
    Mayrin C Medina
    Division of Endocrinology, Diabetes, and Metabolism, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Endocrinology 152:3717-27. 2011
    ..An analogous role is likely in humans, given the similar D3 expression pattern...
  86. ncbi Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice
    S Seino
    Department of Molecular Medicine, Chiba University Graduate School of Medicine, Japan
    Diabetes 49:311-8. 2000
    ..2 knockout mice. Thus, Kir6.2G132S Tg mice and Kir6.2 knockout mice provide a model of type 2 diabetes and clarify the various roles of K(ATP) channels in endocrine pancreatic function...
  87. ncbi Roles of ATP-sensitive K+ channels in cell survival and differentiation in the endocrine pancreas
    T Miki
    Department of Molecular Medicine, Chiba University Graduate School of Medicine, Japan
    Diabetes 50:S48-51. 2001
    ..2G372S Tg and Kir6.2-/- mice compared with the respective controls. Thus, studies of Kir6.2G372S Tg and Kir6.2-/- mice indicate that K(ATP) channels play an important role in cell survival and differentiation in the endocrine pancreas...
  88. pmc Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP
    Jianping Wu
    Department of Biology, Georgia State University, 24 Peachtree Center Avenue, Atlanta, Georgia 30302 4010, USA
    J Physiol 543:495-504. 2002
    ....
  89. ncbi Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population
    F Reimann
    Department of Clinical Biochemistry, University of Cambridge, UK
    Diabetologia 46:241-9. 2003
    ..The aim of this study was to analyse the functional consequences of four CHI mutations (A1457T, V1550D and L1551V in SUR1, and K67N in Kir6.2) recently identified in the Finnish population...
  90. ncbi ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling
    Kohtaro Minami
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Am J Physiol Endocrinol Metab 285:E1289-96. 2003
    ..2 gene. Disruption of Kir6.2-containing Katp channels clearly protects against IRS-1-associated insulin resistance by increasing glucose uptake in skeletal muscles by a mechanism separate from the IRS-1/PI3K pathway...
  91. ncbi A new ATP-sensitive K+ channel-independent mechanism is involved in glucose-excited neurons of mouse arcuate nucleus
    Xavier Fioramonti
    CNRS UMR 5018, Paul Sabatier University, Toulouse, France
    Diabetes 53:2767-75. 2004
    ..Moreover, HGE neurons were also present in ARC of Kir6.2 null mice. These results suggested that ARC neurons have the ability to sense higher glucose concentrations than 5 mmol/l through a new K(ATP) channel-independent mechanism...
  92. ncbi Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K+ channels
    Maria S Remedi
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetes 53:3159-67. 2004
    ..We propose an "inverse U" model for the response to enhanced beta-cell excitability: the expected initial hypersecretion can progress to undersecretion and glucose-intolerance, either spontaneously or in response to dietary stress...
  93. ncbi Role of the sarcolemmal adenosine triphosphate-sensitive potassium channel in hyperkalemic cardioplegia-induced myocyte swelling and reduced contractility
    Sandip M Prasad
    Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Thorac Surg 81:148-53. 2006
    ..To examine whether the mitochondrial or sarcolemmal KATP channel might be involved, volume and contractility in isolated myocytes from wild-type mice and mice lacking the sarcolemmal KATP channel (Kir6.2-/-) were evaluated...
  94. ncbi Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2
    R M J Deacon
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Physiol Behav 87:723-33. 2006
    ..However, according to the widespread expression of K(ATP) channels, these effects are complex, being dependent on details of test apparatus, procedure and prior experience...
  95. ncbi Intracellular ATP-sensitive K+ channels in mouse pancreatic beta cells: against a role in organelle cation homeostasis
    A Varadi
    Henry Wellcome Laboratories for Integrated Cell Signalling and Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    Diabetologia 49:1567-77. 2006
    ..The aim of this study was to explore these possibilities and to test the hypothesis that vesicle-resident channels play a role in the control of organellar Ca(2+) concentration or pH...
  96. ncbi K+ transport and energetics in Kir6.2(-/-) mouse hearts assessed by 87Rb and 31P magnetic resonance and optical spectroscopy
    Olga Jilkina
    Institute for Biodiagnostics, National Research Council of Canada, 435 Ellice Avenue, Winnipeg, MB, Canada R3B 1Y6
    J Mol Cell Cardiol 41:893-901. 2006
    ..Thus Kir6.2 knockout is associated with decreased tolerance of mouse hearts to metabolic inhibition and catecholamine stress...
  97. ncbi Activating of ATP-dependent K+ channels comprised of K(ir) 6.2 and SUR 2B by PGE2 through EP2 receptor in cultured interstitial cells of Cajal from murine small intestine
    Seok Choi
    Department of Physiology, College of Medicine, Chosun University, 375 Seosuk dong, Gwangju, South Korea
    Cell Physiol Biochem 18:187-98. 2006
    ..2-SUR 2B in ICC and this action of PGE(2) are through EP(2) receptor subtype and also the activation of ATP-dependent K(+) channels involves intracellular Ca(2+) mobilization...
  98. ncbi Kir6.2 channel gating by intracellular protons: subunit stoichiometry for ligand binding and channel gating
    Runping Wang
    Department of Biology, Georgia State University, 24 Peachtree Center Avenue, Atlanta, Georgia, 30303 4010, USA
    J Membr Biol 213:155-64. 2006
    ....
  99. pmc Role of sarcolemmal ATP-sensitive K+ channels in the regulation of sinoatrial node automaticity: an evaluation using Kir6.2-deficient mice
    Koichi Fukuzaki
    Department of Pharmacology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Physiol 586:2767-78. 2008
    ..In conclusion, the present study using Kir6.2 KO mice indicates that, during hypoxia, activation of sarcolemmal K(ATP) channels in SAN cells inhibits SAN automaticity, which is important for the protection of SAN cells...
  100. doi Age-dependent involvement of ATP-sensitive potassium channel Kir6.2 in hypoxic ventilatory depression of mouse
    Yoshitaka Oyamada
    Department of Pulmonary Medicine, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, Japan
    Respir Physiol Neurobiol 162:80-4. 2008
    ..12 in N(2)). These findings suggest that Kir6.2 is involved in HVD of the mouse at a certain point during the postnatal development...
  101. doi Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2
    Magalie A Ravier
    Unit of Endocrinology and Metabolism, University of Louvain, Faculty of Medicine, Brussels, Belgium
    Endocrinology 150:33-45. 2009
    ....