Kcnma1

Summary

Gene Symbol: Kcnma1
Description: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Alias: 5730414M22Rik, BKCa, MaxiK, Slo, Slo1, mSlo, mSlo1, calcium-activated potassium channel subunit alpha-1, BK channel alpha subunit, BKCA alpha, KCa1.1, calcium-activated potassium channel, subfamily M subunit alpha-1, k(VCA)alpha, maxi K channel, slo homolog, slo-alpha, slowpoke homolog
Species: mouse

Top Publications

  1. ncbi Diversity of Ca2+-activated K+ channel transcripts in inner ear hair cells
    Kirk W Beisel
    Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA
    Gene 386:11-23. 2007
  2. pmc Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel
    Jill Thompson
    Department of Pharmacology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Gen Physiol 127:159-69. 2006
  3. doi Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia
    Markus Roth
    University of Giessen Lung Center, Excellence Cluster Cardio Pulmonary System, Medical Clinic II V, Klinikstr 36, D 35392 Giessen, Germany
    Am J Respir Crit Care Med 180:353-64. 2009
  4. pmc Measuring the influence of the BKCa {beta}1 subunit on Ca2+ binding to the BKCa channel
    Tara Beth Sweet
    Molecular Cardiology Research Institute, Tufts Medical Center, Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
    J Gen Physiol 133:139-50. 2009
  5. pmc Regulation of STREX exon large conductance, calcium-activated potassium channels by the beta4 accessory subunit
    D Petrik
    Department of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Neuroscience 149:789-803. 2007
  6. pmc Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes
    Giorgio Gorini
    Waggoner Center for Alcohol and Addiction Research, College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA
    FEBS Lett 584:845-51. 2010
  7. pmc Apical maxi-K (KCa1.1) channels mediate K+ secretion by the mouse submandibular exocrine gland
    Tetsuji Nakamoto
    Center for Oral Biology, Department of Pharmacology and Physiology, Univ of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 294:C810-9. 2008
  8. ncbi The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1
    Taku Nagai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
    J Neurosci 26:12374-83. 2006
  9. pmc Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells
    Guiling Zhao
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Gen Physiol 136:283-91. 2010
  10. pmc Aldosterone increases KCa1.1 (BK) channel-mediated colonic K+ secretion
    Mads V Sørensen
    Institute of Physiology and Biophysics, The Water and Salt Research Center, University of Aarhus, 8000 Aarhus C, Denmark
    J Physiol 586:4251-64. 2008

Scientific Experts

Detail Information

Publications110 found, 100 shown here

  1. ncbi Diversity of Ca2+-activated K+ channel transcripts in inner ear hair cells
    Kirk W Beisel
    Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA
    Gene 386:11-23. 2007
    ..These channels are thought to play a role in the tonotopic gradient observed in the mammalian cochlea. Mouse Kcnma1 transcripts, 5' and 3' ESTs, and genomic sequences were examined for the utilization of alternative splicing in ..
  2. pmc Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel
    Jill Thompson
    Department of Pharmacology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Gen Physiol 127:159-69. 2006
    ..This novel, regulated inhibition of maxi-K channels by activation of IK1 adds to the complexity of the properties of these Ca2+-activated K channels and likely contributes to the diversity of their functional roles...
  3. doi Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia
    Markus Roth
    University of Giessen Lung Center, Excellence Cluster Cardio Pulmonary System, Medical Clinic II V, Klinikstr 36, D 35392 Giessen, Germany
    Am J Respir Crit Care Med 180:353-64. 2009
    ..In chronic hypoxia, in addition to HPV a vascular remodeling process leads to pulmonary hypertension. A complex of heme oxygenase-2 (HO-2) and the BK channel has been suggested as a universal oxygen sensor system...
  4. pmc Measuring the influence of the BKCa {beta}1 subunit on Ca2+ binding to the BKCa channel
    Tara Beth Sweet
    Molecular Cardiology Research Institute, Tufts Medical Center, Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
    J Gen Physiol 133:139-50. 2009
    ..Both of these modifications increase the difference in affinity between open and closed, such that Ca(2+) binding at either site has a larger effect on channel opening when beta1 is present...
  5. pmc Regulation of STREX exon large conductance, calcium-activated potassium channels by the beta4 accessory subunit
    D Petrik
    Department of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Neuroscience 149:789-803. 2007
    ....
  6. pmc Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes
    Giorgio Gorini
    Waggoner Center for Alcohol and Addiction Research, College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA
    FEBS Lett 584:845-51. 2010
    ..N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), calcium-activated potassium channel (BKCa) alpha subunits, and dynamin-1...
  7. pmc Apical maxi-K (KCa1.1) channels mediate K+ secretion by the mouse submandibular exocrine gland
    Tetsuji Nakamoto
    Center for Oral Biology, Department of Pharmacology and Physiology, Univ of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 294:C810-9. 2008
    ..1 potassium channels localized to the apical membranes of striated and excretory duct cells in the mouse submandibular exocrine gland...
  8. ncbi The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1
    Taku Nagai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
    J Neurosci 26:12374-83. 2006
    ..Targeting the tPA-plasmin-PAR1 system would provide new therapeutic approaches to the treatment of nicotine dependence...
  9. pmc Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells
    Guiling Zhao
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Gen Physiol 136:283-91. 2010
    ..In summary, data indicate that IP(3)R1 activation elevates BK(Ca) channel apparent Ca(2+) sensitivity through local molecular coupling in arterial smooth muscle cells...
  10. pmc Aldosterone increases KCa1.1 (BK) channel-mediated colonic K+ secretion
    Mads V Sørensen
    Institute of Physiology and Biophysics, The Water and Salt Research Center, University of Aarhus, 8000 Aarhus C, Denmark
    J Physiol 586:4251-64. 2008
    ..Taken together, these data strongly suggest that aldosterone-induced K(+) secretion occurs via increased expression of luminal BK channels...
  11. ncbi mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels
    A Butler
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110
    Science 261:221-4. 1993
    Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes...
  12. ncbi Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpoke
    L Pallanck
    Laboratory of Genetics, University of Wisconsin Madison 53706
    Hum Mol Genet 3:1239-43. 1994
    ....
  13. ncbi Control of alternative splicing of potassium channels by stress hormones
    J Xie
    Section of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    Science 280:443-6. 1998
    ..Expression of alternative splice variants of Slo, a gene encoding calcium- and voltage-activated potassium channels, was measured in rat adrenal chromaffin tissue ..
  14. ncbi A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels
    T M Weiger
    Department of Biochemistry and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 20:3563-70. 2000
    ..beta4 may be important for the critical roles played by Slowpoke channels in the regulation of neuronal excitability and neurotransmitter release...
  15. pmc Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivity
    Lin Bao
    Molecular Cardiology Research Institute, New England Medical Center, and the Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
    J Gen Physiol 120:173-89. 2002
    ..Estimates of the binding characteristics of the BK(Ca) channel's high-affinity Ca(2+)-binding sites are provided...
  16. ncbi Mechanism of magnesium activation of calcium-activated potassium channels
    Jingyi Shi
    Cardiac Bioelectricity Research and Training Center and Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    Nature 418:876-80. 2002
    ..These results indicate distinct structural pathways for Mg(2+)- and Ca(2+)-dependent activation and suggest a possible mechanism for the coupling between Mg(2+) binding and channel opening...
  17. ncbi Multiple regulatory sites in large-conductance calcium-activated potassium channels
    Xiao Ming Xia
    Department of Anesthesiology, Washington University School of Medicine, Box 8054, St Louis, Missouri 63110, USA
    Nature 418:880-4. 2002
    ..This allows BK channels to serve a variety of physiological roles contingent on the Ca(2+) concentration to which the channels are exposed...
  18. ncbi Molecular identification of Ca2+-activated K+ channels in parotid acinar cells
    Keith Nehrke
    Center for Oral Biology, Aab Institute of Biomedical Sciences, and Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Physiol Cell Physiol 284:C535-46. 2003
    ..with the intermediate and maxi-K classes of Ca(2+)-activated K(+) channels, typified by the mIK1 (Kcnn4) and mSlo (Kcnma1) genes, respectively. The presence of mIK1 mRNA was established in acinar cells by in situ hybridization...
  19. pmc Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels
    Lei Hu
    Cardiac Bioelectricity Research and Training Center and Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 100:10488-93. 2003
    ..These results indicate that the voltage sensor is critical for Mg2+-dependent activation and the coupling between the voltage sensor and channel gate is a converging point for voltage- and Mg2+-dependent activation pathways...
  20. ncbi Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel
    Andrea L Meredith
    Department of Molecular and Cellular Physiology and the Howard Hughes Medical Institute, 279 Campus Drive, Stanford University, Stanford, CA 94305, USA
    J Biol Chem 279:36746-52. 2004
    ..To address the role of the BK channel in urinary bladder function, the gene mSlo1 for the pore-forming subunit of the BK channel was deleted...
  21. pmc Unique inner pore properties of BK channels revealed by quaternary ammonium block
    Weiyan Li
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Gen Physiol 124:43-57. 2004
    ..These features could potentially contribute to the large conductance of BK channels...
  22. pmc Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss
    Lukas Ruttiger
    Department of Otorhinolaryngology, Tübingen Hearing Research Center, Molecular Neurobiology, University of Tubingen, Elfriede Aulhorn Strasse 5, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 101:12922-7. 2004
    ..loss of KCNQ4 in OHCs, and OHC degeneration requires further investigation, data already suggest human BK-coding slo1 gene mutation as a susceptibility factor for progressive deafness, similar to KCNQ4 potassium channel mutations.
  23. ncbi Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice
    Matthias Sausbier
    Pharmakologie und Toxikologie, Pharmazeutisches Institut der Universität Tübingen, Tubingen, Germany
    Circulation 112:60-8. 2005
    ..However, the BK channel may also affect blood pressure by regulating salt and fluid homeostasis, particularly by adjusting the renin-angiotensin-aldosterone system...
  24. ncbi Functionally diverse complement of large conductance calcium- and voltage-activated potassium channel (BK) alpha-subunits generated from a single site of splicing
    Lie Chen
    Centre for Integrative Physiology, Membrane Biology Group, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, United Kingdom
    J Biol Chem 280:33599-609. 2005
    ....
  25. pmc The role of BKCa channels in electrical signal encoding in the mammalian auditory periphery
    Dominik Oliver
    Physiologisches Institut, Universitat Freiburg, D 79104 Freiburg, Germany
    J Neurosci 26:6181-9. 2006
    Large-conductance voltage- and Ca(2+)-activated K+ channels (BKCa) are involved in shaping spiking patterns in many neurons...
  26. ncbi Two classes of outer hair cells along the tonotopic axis of the cochlea
    J Engel
    University of Tubingen, Institute of Physiology II and Department of Otolaryngology, THRC, Gmelinstrasse 5, 72076 Tubingen, Germany
    Neuroscience 143:837-49. 2006
    ..Our findings propose new mechanisms and candidate genes for explaining high and low frequency hearing loss...
  27. ncbi Cochlear function in mice lacking the BK channel alpha, beta1, or beta4 subunits
    Sonja J Pyott
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 282:3312-24. 2007
    ..cells, we analyzed the morphology, physiology, and function of these cells from mice lacking the BK channel alpha (Slo-/-) and also the beta1 and beta4 subunits (beta1/4-/-)...
  28. ncbi Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+ channel
    Matthias Sausbier
    Pharmakologie und Toxikologie, Pharmazeutisches Institut, Universitat Tubingen, Tubingen, Germany
    FASEB J 21:812-22. 2007
    ....
  29. doi The molecular mechanism of "ryegrass staggers," a neurological disorder of K+ channels
    Wendy L Imlach
    AgResearch, Grasslands Research Centre, Palmerston North, New Zealand
    J Pharmacol Exp Ther 327:657-64. 2008
    ..to inhibition of BK ion channels, their ability to induce tremor and ataxia in mice deficient in this ion channel (Kcnma1(-/-)) was examined. Our results show that mice lacking Kcnma1 are unaffected by these neurotoxins...
  30. pmc BK channels in innate immune functions of neutrophils and macrophages
    Kirill Essin
    Department of Nephrology, Campus Virchow, Medical Faculty of the Charite, Experimental and Clinical Research Center at the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Blood 113:1326-31. 2009
    ..Based on these data, we conclude that the BK channel is not required for NADPH oxidase activity in PMNs or macrophages or for endotoxin-triggered tumor necrosis factor-alpha release and signal transduction BMDMs...
  31. pmc Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder
    Franz Sprossmann
    Pharmakologie und Toxikologie, Institut fur Pharmazie, Universitat Tubingen, Germany
    FEBS J 276:1680-97. 2009
    ..Thus, constitutive and inducible deletion of BK channel activity unmasks compensatory mechanisms that are relevant for urinary bladder relaxation...
  32. pmc Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine
    Qiong Yao Tang
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA
    Channels (Austin) 4:22-41. 2010
    ..The Slo3 channel shares extensive homology with Ca(2+)- and voltage-regulated BK-type Slo1 K(+) channels...
  33. pmc Bidirectional control of BK channel open probability by CAMKII and PKC in medial vestibular nucleus neurons
    Ingrid van Welie
    Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, San Diego, CA 92037, USA
    J Neurophysiol 105:1651-9. 2011
    ....
  34. pmc MitoBK(Ca) is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location
    Harpreet Singh
    Department of Anesthesiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 110:10836-41. 2013
    The large-conductance Ca(2+)- and voltage-activated K(+) channel (BK(Ca), MaxiK), which is encoded by the Kcnma1 gene, is generally expressed at the plasma membrane of excitable and nonexcitable cells...
  35. pmc Regulation of BK-α expression in the distal nephron by aldosterone and urine pH
    Donghai Wen
    Dept of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198 5850
    Am J Physiol Renal Physiol 305:F463-76. 2013
    ..These data suggest that aldosterone mediates a high-K-induced increase in BK-α and urinary alkalinization increases BK-β4 expression, which promotes the apical localization of BK-α. ..
  36. ncbi Allosteric linkage between voltage and Ca(2+)-dependent activation of BK-type mslo1 K(+) channels
    J Cui
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biochemistry 39:15612-9. 2000
    ..We studied three point mutations in the putative voltage sensor S4 or S4-S5 linker regions in the mslo1 BK channels to explore the relationship between voltage and Ca(2+) in activating the channel...
  37. pmc Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency
    M Sausbier
    Pharmakologie und Toxikologie, Pharmazeutisches Institut, Universitat Tubingen, D 72076 Tuebingen, Germany
    Proc Natl Acad Sci U S A 101:9474-8. 2004
    ..These results identify previously unknown roles of potassium channels in mammalian cerebellar function and motor control. In addition, they provide a previously undescribed animal model of cerebellar ataxia...
  38. pmc BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output
    Andrea L Meredith
    Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 9:1041-9. 2006
    ..BK channel-null mice (Kcnma1(-/-)) have increased SFRs in SCN neurons selectively at night and weak circadian amplitudes in multiple behaviors ..
  39. ncbi The cytoplasmic tail of large conductance, voltage- and Ca2+-activated K+ (MaxiK) channel is necessary for its cell surface expression
    Shao Xiong Wang
    Department of Physiology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Biol Chem 278:2713-22. 2003
    The large conductance, voltage- and Ca(2+)-activated K(+) channel (MaxiK) is expressed in several renal segments and functions in cell volume regulation and flow-mediated K(+) secretion...
  40. doi Dendritic mechanisms controlling the threshold and timing requirement of synaptic plasticity
    Cuiping Zhao
    Department of Neuroscience, University of Minnesota, Minneapolis, USA
    Hippocampus 21:288-97. 2011
    ..In conclusion, dendritic A-type and Ca(2+) -activated K(+) channels dually regulate the timing-dependence and thresholds of synaptic plasticity in an additive way...
  41. doi Temporal and spatial mouse brain expression of cereblon, an ionic channel regulator involved in human intelligence
    Joseph J Higgins
    Department of Pediatrics, Division of Pediatric Neurology, York Presbyterian Hospital, Weill Cornell Medical College, New York, New York 10065, USA
    J Neurogenet 24:18-26. 2010
    ..An mRNA variant (human SITE 2 INSERT or mouse strex) of the BK(Ca) gene (KCNMA1) that is normally expressed during embryonic development is aberrantly expressed in mutCRBN human lymphoblastoid ..
  42. pmc Modulation of BK channel gating by the ß2 subunit involves both membrane-spanning and cytoplasmic domains of Slo1
    Urvi S Lee
    Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, Missouri 63130, USA
    J Neurosci 30:16170-9. 2010
    ..BK channels are composed of four Slo1 subunits, which contain the voltage-sensing and pore-gate domains in the membrane and Ca(2+) binding sites in the ..
  43. pmc PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity
    Pimonrat Ketsawatsomkron
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Circ Res 111:1446-58. 2012
    ..Previous studies suggest these effects may be mediated through the vasculature, but the underlying mechanisms remain unclear...
  44. pmc A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel
    Andrew P Wojtovich
    Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Peerj 1:e48. 2013
    ..Herein we confirmed that openers of the SLO1 BK channel, NS1619 and NS11021, were protective in a mouse perfused heart model of IR injury...
  45. pmc Characteristics of single large-conductance Ca2+-activated K+ channels and their regulation of action potentials and excitability in parasympathetic cardiac motoneurons in the nucleus ambiguus
    Min Lin
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida
    Am J Physiol Cell Physiol 306:C152-66. 2014
    ..We conclude that activation of BK channels underlies one of the mechanisms for facilitation of PCMN excitability...
  46. pmc Mice with deficient BK channel function show impaired prepulse inhibition and spatial learning, but normal working and spatial reference memory
    Marei Typlt
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 8:e81270. 2013
    ..We tested the F1 generation of a hybrid SV129/C57BL6 mouse line in which the slo1 gene was deleted in both parent strains...
  47. doi BKCa channels expressed in sensory neurons modulate inflammatory pain in mice
    Ruirui Lu
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Pain 155:556-65. 2014
    Large conductance calcium-activated potassium (BKCa) channels are important regulators of neuronal excitability...
  48. doi CaV1.3 L-type channels, maxiK Ca(2+)-dependent K(+) channels and bestrophin-1 regulate rhythmic photoreceptor outer segment phagocytosis by retinal pigment epithelial cells
    Claudia Müller
    Experimental Ophthalmology, Eye Hospital, University Medical Center Regensburg, Franz Josef Straus Allee 11, 93053 Regensburg, Germany
    Cell Signal 26:968-78. 2014
    ..3 L-type Ca(2+) channels (Ca1.3(-/-)) and maxiK Ca(2+)-dependent K(+) channels (BK(-/-))...
  49. doi Cellular mechanism underlying hydrogen sulfide induced mouse tracheal smooth muscle relaxation: role of BKCa
    Jiehong Huang
    School of Life Sciences, Sun Yat Sen University, No 135, Xingang Xi Road, Guangzhou 510275, PR China
    Eur J Pharmacol 741:55-63. 2014
    ..TSM induced by NaHS was abrogated by iberiotoxin (IbTX), the large conductance calcium activated potassium channel (BKCa) blocker...
  50. pmc Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity
    Pedro L Martinez-Espinosa
    Department of Anesthesiology, Washington University School of Medicine in St Louis, St Louis, MO 63110
    J Gen Physiol 144:275-95. 2014
    ..from the assembly of up to four β2 auxiliary subunits (encoded by the kcnmb2 gene) with a tetramer of pore-forming Slo1 α subunits...
  51. pmc Genetic ablation of CaV3.2 channels enhances the arterial myogenic response by modulating the RyR-BKCa axis
    Osama F Harraz
    From the Department of Physiology and Pharmacology, Hotchkiss Brain and Libin Cardiovascular Institutes, University of Calgary, Calgary, Alberta, Canada O F H, S E B, A Z, D G W Department of Pharmacology and Toxicology, Alexandria University, Alexandria, Egypt O F H Department of Basic Sciences, Division of Pharmacology, Loma Linda University, CA M R, S M W Department of Pharmacology, University of California, Davis J L P and Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada D G W
    Arterioscler Thromb Vasc Biol 35:1843-51. 2015
    ..arterial constriction through a feedback response involving the large-conductance Ca(2+)-activated K(+) channel (BKCa). Here, we used wild-type and CaV3.2 knockout (CaV3.2(-/-)) mice to definitively test whether CaV3...
  52. pmc BK channel inactivation gates daytime excitability in the circadian clock
    Joshua P Whitt
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Nat Commun 7:10837. 2016
    ..Our study reveals the clock employs inactivation gating as a biophysical switch to set the diurnal variation in suprachiasmatic nucleus excitability that underlies circadian rhythm. ..
  53. pmc BK Knockout by TALEN-Mediated Gene Targeting in Osteoblasts: KCNMA1 Determines the Proliferation and Differentiation of Osteoblasts
    Hongya Hei
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China
    Mol Cells 39:530-5. 2016
    ....
  54. doi Perinatal hypoxia enhances cyclic adenosine monophosphate-mediated BKCa channel activation in adult murine pulmonary artery
    Mathieu Marino
    Laboratory of Vascular Cell Physiology, Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland
    J Cardiovasc Pharmacol 57:154-65. 2011
    ..In summary, perinatal hypoxia enhanced cAMP-mediated BK(Ca) channels activation in adult murine PA, suggesting that this pathway could be a potential target for modulating adult pulmonary vascular tone after perinatal hypoxia...
  55. pmc Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability
    Jenna R Montgomery
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 109:18997-9002. 2012
    ..Alteration of BK currents in Tg-BK(R207Q) SCN neurons increased firing at night but decreased firing during the day, demonstrating that BK currents generate bidirectional effects on neuronal firing under distinct conditions...
  56. pmc Quantitative localization of Cav2.1 (P/Q-type) voltage-dependent calcium channels in Purkinje cells: somatodendritic gradient and distinct somatic coclustering with calcium-activated potassium channels
    Dwi Wahyu Indriati
    Department of Physiological Sciences, Graduate University for Advanced Studies SOKENDAI, Myodaiji, Okazaki 444 8787, Japan
    J Neurosci 33:3668-78. 2013
    ..Calcium nanodomain created by the opening of Ca(v)2.1 channels likely activates the two channels that limit the extent of depolarization...
  57. ncbi Response to Listeria monocytogenes in mice lacking MHC class Ia molecules
    M S Seaman
    Immunology Graduate Program, Center for Immunology, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Immunol 162:5429-36. 1999
    ..Thus, class Ia-deficient animals have a CD8+ T cell repertoire capable of recognizing both class Ia and class Ib molecules and can generate protective immunity to LM...
  58. ncbi Molecular components of large conductance calcium-activated potassium (BK) channels in mouse pituitary corticotropes
    M J Shipston
    Department of Biomedical Sciences, University of Edinburgh Medical School, Scotland, UK
    Mol Endocrinol 13:1728-37. 1999
    ..RT-PCR cloning and splice variant analysis of mouse AtT20 D16:16 corticotropes revealed robust expression of mslo transcripts encoding pore-forming alpha-subunits containing the mouse homolog of the 59-amino acid STREX-1 exon at ..
  59. ncbi 17beta-Estradiol upregulates distinct maxi-K channel transcripts in mouse uterus
    Amanda J Holdiman
    Department of Physiology and Biophysics, 5 660 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USA
    Mol Cell Endocrinol 192:1-6. 2002
    ..These findings verify that maxi-K channel transcripts are differentially spliced by 17beta-estradiol, which may contribute to stoichiometric changes in isoform expression during pregnancy...
  60. ncbi Myometrial maxi-K channel beta1 subunit modulation during pregnancy and after 17beta-estradiol stimulation
    Nancy A Benkusky
    Department of Physiology and Biophysics, 5 660 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USA
    FEBS Lett 524:97-102. 2002
    ..These findings verify that beta1 subunit transcript is regulated in mouse myometrium during gestation and estrogens may contribute to this increase...
  61. ncbi Leucine zipper domain targets cAMP-dependent protein kinase to mammalian BK channels
    Lijun Tian
    Membrane Biology Group, Division of Biomedical Sciences, University of Edinburgh Medical School, Scotland, United Kingdom
    J Biol Chem 278:8669-77. 2003
    ..Thus LZ1 is required for the association and regulation of mammalian BK channels by PKA, and other putative leucine zippers in the BK channel protein may provide anchoring for other regulatory enzyme complexes...
  62. ncbi Localization and developmental expression of BK channels in mammalian cochlear hair cells
    A Hafidi
    Laboratoire de Biologie Cellulaire et Moleculaire de l Audition, EA 3665, Universite de Bordeaux 2, Laboratoire de Biologie Cellulaire et Moleculaire de l Audition, CHU Hôpital Pellegrin, 33076 Bordeaux, France
    Neuroscience 130:475-84. 2005
    The expression of Slo channels (alpha subunits of BK channels) was investigated in the developing mouse cochlea using a polyclonal antibody against the C-terminal part of the protein (residues 1098-1196)...
  63. ncbi Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder
    K S Thorneloe
    Dept of Pharmacology, College of Medicine, Univ of Vermont, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 289:F604-10. 2005
    ..J Biol Chem 279: 36746-36752, 2004) that the gene mSlo1 encodes large-conductance Ca2+-activated K+ (BK) channels of urinary bladder smooth muscle (UBSM) and that ..
  64. pmc Ring of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics
    Yaxia Zhang
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    J Gen Physiol 128:185-202. 2006
    ....
  65. pmc State-dependent block of BK channels by synthesized shaker ball peptides
    Weiyan Li
    Section of Neurobiology, University of Texas at Austin, Austin, TX 78712, USA
    J Gen Physiol 128:423-41. 2006
    ..Furthermore, our results from two BK channel mutations demonstrate that similar types of interactions between ball peptides and channels are shared by BK and other K(+) channel types...
  66. pmc Intra- and intersubunit cooperativity in activation of BK channels by Ca2+
    Xiang Qian
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    J Gen Physiol 128:389-404. 2006
    ..Ca(2+) response for eight possible subunit configurations of the high-affinity Ca(2+) sensors as well as for three additional configurations from a previous study...
  67. ncbi Interaction sites between the Slo1 pore and the NH2 terminus of the beta2 subunit, probed with a three-residue sensor
    Hui Li
    Institute of Biochemistry and Biophysics, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China
    J Biol Chem 282:17720-8. 2007
    Calcium- and voltage-gated (BK) K(+) channels encoded by Slo1 play an essential role in nervous systems...
  68. ncbi The role of the BK channel in potassium homeostasis and flow-induced renal potassium excretion
    T Rieg
    Institute of Pharmacology and Toxicology, Medical Faculty of the Eberhard Karls University, Wilhelmstrasse 56, 72074 Tubingen, Germany
    Kidney Int 72:566-73. 2007
    ..These studies suggest a role of the BK channel alpha-subunit in flow-induced K(+) secretion and in K(+) homeostasis. Higher aldosterone and an upregulation of ROMK may compensate for the absence of functional BK channels...
  69. ncbi Regulation of mouse Slo gene expression: multiple promoters, transcription start sites, and genomic action of estrogen
    Pallob Kundu
    Department of Anesthesiology, Division of Molecular Medicine, University of California Los Angeles, CA 90095, USA
    J Biol Chem 282:27478-92. 2007
    ..In mouse (m), estrogen up-regulates the transcript levels of its pore-forming alpha-subunit (Slo, KCNMA1), yet the underlying genomic mechanism(s) is (are) unknown...
  70. ncbi Stimulatory actions of di-8-butyl-amino-naphthyl-ethylene-pyridinium-propyl-sulfonate (di-8-ANEPPS), voltage-sensitive dye, on the BKCa channel in pituitary tumor (GH3) cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, No 1, University Road, Tainan 70101 Taiwan, Republic of China
    Pflugers Arch 455:687-99. 2008
    ..Taken together, this study suggests that during the exposure to di-8-ANEPPS, the stimulatory effects on BK(Ca) channels could be one of potential mechanisms through which it may affect cell excitability...
  71. ncbi 17beta-estradiol at physiological concentrations augments Ca(2+) -activated K+ currents via estrogen receptor beta in the gonadotropin-releasing hormone neuronal cell line GT1-7
    Ichiro Nishimura
    Department of Physiology, Nippon Medical School, Bunkyo, Tokyo, Japan
    Endocrinology 149:774-82. 2008
    ..In conclusion, E2 at physiological concentrations augments K(Ca) currents through ERbeta in the GT1-7 GnRH neuronal cell line and increases the expression of the BK channel subunit mRNAs, alpha and beta4...
  72. pmc Position and role of the BK channel alpha subunit S0 helix inferred from disulfide crosslinking
    Guoxia Liu
    1 Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Gen Physiol 131:537-48. 2008
    ....
  73. pmc Hypercontractility and impaired sildenafil relaxations in the BKCa channel deletion model of erectile dysfunction
    Matthias E Werner
    Division of Cardiovascular and Endocrine Sciences, School of Medicine, University of Manchester, Manchester, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 295:R181-8. 2008
    ..One important target of PKGI in smooth muscle is the large-conductance, Ca2+ -activated potassium (BKCa) channel...
  74. pmc BK channels regulate spontaneous action potential rhythmicity in the suprachiasmatic nucleus
    Jack Kent
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 3:e3884. 2008
    ..The BK K(+) channel plays an important role in suppressing spontaneous firing at night in SCN neurons. Deletion of the Kcnma1 gene, encoding the BK channel, causes degradation of circadian behavioral and physiological rhythms.
  75. pmc Bimane fluorescence scanning suggests secondary structure near the S3-S4 linker of BK channels
    Nina P Semenova
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Biol Chem 284:10684-93. 2009
    ..Our results suggest a working hypothesis for the secondary structure of the BK channel S3-S4 region, and places residues Leu-204, Gly-205, and Leu-206 within the extracellular end of the S4 helix...
  76. pmc A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea
    Thandavarayan Kathiresan
    Department of Otolaryngology Head and Neck Surgery, University of South Florida, College of Medicine, Tampa, Florida 33612, USA
    Mol Cell Proteomics 8:1972-87. 2009
    ..The studies described herein provide insights into BK-related functions that include not only cell excitation, but also cell signaling and apoptosis, and involve proteins concerned with Ca(2+) regulation, structure, and hearing loss...
  77. doi Cloning of large-conductance Ca(2+)-activated K(+) channel alpha-subunits in mouse cardiomyocytes
    Jae Hong Ko
    Department of Physiology, College of Medicine, Chung Ang University, Seoul, South Korea
    Biochem Biophys Res Commun 389:74-9. 2009
    ..in mouse cardiomyocytes, with amino acids 41-1153 being identical to calcium-activated potassium channel SLO1 and amino acids 1-40 corresponding to BK(Ca) channel subfamily M alpha member 1...
  78. pmc Alpha5beta1 integrin engagement increases large conductance, Ca2+-activated K+ channel current and Ca2+ sensitivity through c-src-mediated channel phosphorylation
    Yan Yang
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    J Biol Chem 285:131-41. 2010
    ..Here, we show that macroscopic currents from HEK 293 cells expressing murine BK channel alpha-subunits (mSlo) are acutely potentiated following alpha5beta1 integrin activation...
  79. pmc BK channels control cerebellar Purkinje and Golgi cell rhythmicity in vivo
    Guy Cheron
    Laboratory of Electrophysiology, Université Mons Hainaut, Mons, Belgium
    PLoS ONE 4:e7991. 2009
    ..We hypothesize that the temporal coding modification of the spike firing of both Purkinje and Golgi cells leads to the pharmacologically or genetically induced ataxia...
  80. pmc Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction
    Helene Girouard
    Department of Pharmacology, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 107:3811-6. 2010
    ....
  81. pmc Adrenaline-induced colonic K+ secretion is mediated by KCa1.1 (BK) channels
    Mads V Sørensen
    Department of Physiology and Biophysics, The Water and Salt Research Center, Aarhus University, 8000 Aarhus C, Denmark
    J Physiol 588:1763-77. 2010
    ..In summary, these results strongly suggest that the adrenaline-induced distal colonic K(+) secretion is mediated by the BK channel and probably involves aldosterone-induced ZERO splice variant up-regulation...
  82. pmc Dual role of protein kinase C on BK channel regulation
    Xiao Bo Zhou
    Institute of Pharmacology for Pharmacists, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    Proc Natl Acad Sci U S A 107:8005-10. 2010
    ..It is shown that this complex regulation is not only effective in recombinant channels but also in native BK channels from tracheal smooth muscle...
  83. pmc Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels
    Xiaowei Chen
    Center for Integrated Protein Science and Institute of Neuroscience, Technical University Munich, 80802 Munich, Germany
    Proc Natl Acad Sci U S A 107:12323-8. 2010
    ..Taken together, our results establish an essential role of BK channels of PNs for both cerebellar motor coordination and feedback regulation in the olivo-cerebellar loop...
  84. pmc Two distinct pools of large-conductance calcium-activated potassium channels in the somatic plasma membrane of central principal neurons
    W A Kaufmann
    Department of Pharmacology, Innsbruck Medical University, Peter Mayr Strasse 1a, 6020 Innsbruck, Austria
    Neuroscience 169:974-86. 2010
    ..This study indicates a common organizational principle for somatic BK(Ca) channels in central principal neurons with the formation of a clustered and a scattered pool of channels, and a cell-type specific density of this channel type...
  85. pmc Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments
    Eun Young Kim
    Department of Biology and Biochemistry, University of Houston, Texas 77204 5001, USA
    Am J Physiol Renal Physiol 299:F594-604. 2010
    Mechanosensitive large-conductance Ca(2+)-activated K(+) channels encoded by the Slo1 gene (BK(Ca) channels) are expressed in podocytes...
  86. doi Differential suppression of tumor-specific CD8+ T cells by regulatory T cells
    Edward James
    Cancer Sciences Division, School of Medicine, University of Southampton, Southampton, Hampshire, United Kingdom
    J Immunol 185:5048-55. 2010
    ..This work has allowed us to demonstrate how the specificity of CTL responses to tumor Ags can be controlled via differential suppression of CTL specificities by Tregs, and how this can result in very different physiological outcomes...
  87. pmc BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells
    M Dufer
    Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Tubingen, Auf der Morgenstelle 8, 72076 Tubingen, Germany
    Diabetologia 54:423-32. 2011
    ..We used BK channel knockout (BK-KO) mice to examine the role of these K(Ca) channels for glucose homeostasis, beta cell function and viability...
  88. pmc Effects of insulin and high glucose on mobilization of slo1 BKCa channels in podocytes
    Eun Young Kim
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    J Cell Physiol 226:2307-15. 2011
    ..Large-conductance Ca(2+)-activated K(+) channels (BK(Ca) channels) encoded by the Slo1 gene are expressed in podocytes in a complex with multiple glomerular slit diaphragm proteins including nephrin, ..
  89. ncbi Mouse LIM-kinase 2 gene: cDNA cloning, genomic organization, and tissue-specific expression of two alternatively initiated transcripts
    C Ikebe
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Genomics 46:504-8. 1997
    ..Limk2a and Limk2b transcripts were expressed at different ratios in a variety of mouse tissues...
  90. ncbi A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels
    J Xie
    Howard Hughes Medical Institute, and Department of Microbiology and Molecular Genetics, University of California Los Angeles, California 90095 1662, USA
    Nature 410:936-9. 2001
    ..The CaRRE presents a unique molecular target for inducing long-term adaptive changes in cellular electrical properties. It also provides a model system for dissecting the effect of signal transduction pathways on alternative splicing...
  91. pmc A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltage- and Ca-activated K (BK) channel alpha-subunits
    Claire E McCartney
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, United Kingdom
    Proc Natl Acad Sci U S A 102:17870-6. 2005
    ..Because STREX splice-variant expression is tissue-specific and dynamically controlled, alternative splicing of BK channels provides a mechanism to control the plasticity of cellular responses to hypoxia...
  92. pmc Mechanism of beta4 subunit modulation of BK channels
    Bin Wang
    Department of Physiology, University of Texas Health Science Center at San Antonio, 78229, USA
    J Gen Physiol 127:449-65. 2006
    ..However, beta4 confers a compensatory effect on voltage sensor activation that increases channel opening during depolarization...
  93. ncbi Distal colonic K(+) secretion occurs via BK channels
    Matthias Sausbier
    Pharmakologie und Toxikologie, Pharmazeutisches Institut, Universitat Tubingen, Tubingen, Germany
    J Am Soc Nephrol 17:1275-82. 2006
    ..It is concluded that BK channels are the responsible K(+) channels for resting and stimulated Ca(2+)-activated K(+) secretion in mouse distal colon...
  94. ncbi Molecular identification and physiological roles of parotid acinar cell maxi-K channels
    Victor Romanenko
    Department of Pharmacology and Physiology, University of Rochester Medical Center, New York 14642, USA
    J Biol Chem 281:27964-72. 2006
    ....
  95. pmc Regulation of membrane potential and fluid secretion by Ca2+-activated K+ channels in mouse submandibular glands
    Victor G Romanenko
    Center for Oral Biology in the Aab Institute of Biomedical Sciences and Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Physiol 581:801-17. 2007
    ..Finally, we found that the modest hyperpolarization of cells from the double-null mice was maintained by the electrogenic Na(+),K(+)-ATPase...
  96. pmc Ion channel gene expression in the inner ear
    Irene S Gabashvili
    Hewlett Packard Labs, 1501 Page Mill Road, Palo Alto, CA 94304, USA
    J Assoc Res Otolaryngol 8:305-28. 2007
    ..A lack of data and incomplete gene annotations prevent both rigorous statistical analyses and comparisons of entire ion channelomes derived from different tissues and organisms...
  97. ncbi The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BK alpha channel subunit in rodents
    Hantz C Hercule
    Nephrology Hypertension Division, Franz Volhard Clinic, HELIOS Klinikum Berlin, Campus Buch, Berlin, Germany
    Exp Physiol 92:1067-76. 2007
    ..Finally, the action of 17,18-EETeTr is not mediated by changes of the internal global calcium concentration or local SR calcium release events...
  98. doi Insulin increases the activity of mesangial BK channels through MAPK signaling
    Ruth M Foutz
    Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Am J Physiol Renal Physiol 294:F1465-72. 2008
    ..These results indicate that insulin activates BK in the plasma membrane of MC and stimulates, via MAPK, an increase in cellular and plasma membrane BK-alpha...
  99. pmc Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel
    Sean M Brown
    Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Coker Life Sciences Bldg, Rm 709, 715 Sumter St, Columbia, SC 29208, USA
    Am J Physiol Renal Physiol 295:F1149-57. 2008
    ....
  100. pmc A mutually exclusive alternative exon of slo1 codes for a neuronal BK channel with altered function
    Malle Soom
    Center for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena, Jena, Germany
    Channels (Austin) 2:278-82. 2008
    Large-conductance Ca(2+)- and voltage-activated K(+) (BK) channels are comprised of four pore-forming -subunits (Slo1), whose mRNA is alternatively spliced in a cell-specific manner...
  101. pmc Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains
    Huanghe Yang
    Department of Biomedical Engineering, and Cardiac Bioelectricity and Arrhythmia Center, Washington University, 1 Brookings Drive, St Louis, Missouri 63130, USA
    Nat Struct Mol Biol 15:1152-9. 2008
    ..These results suggest that the VSD and the cytoplasmic domains from different subunits may interact during channel gating, and the packing of VSD or the RCK1 domain to the pore in BK channels differ from that in Kv1.2 or MthK channels...

Research Grants4

  1. MECHANISM OF REGULATION OF A GLOMERULAR K CHANNEL
    STEVEN SANSOM; Fiscal Year: 2005
    ..Ultimately, better management of some forms of hypertension could develop from an in-depth understanding of BK regulatory mechanism at the molecular level. ..
  2. Role of TRP Channels in Statin Reversal of Nephropathy in Early Stage Type 2 DM
    STEVEN SANSOM; Fiscal Year: 2009
    ..These studies will determine if and how a certain drug, simvastatin, can be used to treat patients in the early stage of type 2 diabetes mellitus and prevent or slow the progression of kidney disease. ..
  3. Positional cloning of a gene for mental retardation
    Joseph Higgins; Fiscal Year: 2004
    ..abstract_text> ..
  4. POSITIONAL CLONING OF A GENE FOR ESSENTIAL TREMOR
    Joseph Higgins; Fiscal Year: 2004
    ..abstract_text> ..