Lef1

Summary

Gene Symbol: Lef1
Description: lymphoid enhancer binding factor 1
Alias: 3000002B05, AI451430, Lef-1, lymphoid enhancer-binding factor 1
Species: mouse

Top Publications

  1. pmc Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2
    Hiroki Hikasa
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 286:12093-100. 2011
  2. pmc Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin
    B J Merrill
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 15:1688-705. 2001
  3. doi R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis
    Sheila M Bell
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Development 135:1049-58. 2008
  4. doi Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis
    Xuming Zhu
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, China
    Dev Biol 365:328-38. 2012
  5. ncbi Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region
    Claudia Orelio
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 101:2246-9. 2003
  6. pmc Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells
    Mohammad B Hossain
    Department of Immunology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Immunology 125:377-86. 2008
  7. pmc Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
    Krzysztof Kobielak
    Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021 6399, USA
    J Cell Biol 163:609-23. 2003
  8. ncbi Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections
    H Chen
    Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco 94243 0452, USA
    Neuron 25:43-56. 2000
  9. ncbi Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells
    Zhe Xiong Jin
    Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    J Immunol 169:3783-92. 2002
  10. pmc Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin
    Jane Goodall
    Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Mol Cell Biol 24:2915-22. 2004

Research Grants

  1. MECHANISMS OF RAAV TRANSDUCTION IN THE AIRWAY
    JOHN ENGELHARDT; Fiscal Year: 2008
  2. Redox-mediated NF-kappaB activation by LPS and IL-1
    JOHN ENGELHARDT; Fiscal Year: 2008
  3. ROLES OF SOX C GENES IN SKELETOGENESIS
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications132 found, 100 shown here

  1. pmc Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2
    Hiroki Hikasa
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 286:12093-100. 2011
    ..We show that the TCF family members LEF1, TCF4, and TCF3 are phosphorylated in embryonic ectoderm after Wnt8 stimulation and HIPK2 overexpression...
  2. pmc Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin
    B J Merrill
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 15:1688-705. 2001
    ..In this paper, we show that Tcf3 and Lef1 control these differentiation lineages...
  3. doi R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis
    Sheila M Bell
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Development 135:1049-58. 2008
    ..Interbreeding the Rspo2(Tg) and Lrp6(-) alleles resulted in more severe defects consisting of marked lung hypoplasia and absence of tracheal-bronchial rings, laryngeal structures and all limb skeletal elements...
  4. doi Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis
    Xuming Zhu
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, China
    Dev Biol 365:328-38. 2012
    ..These findings provide a comprehensive view of the role of Wnts in limb patterning and tissue morphogenesis...
  5. ncbi Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region
    Claudia Orelio
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 101:2246-9. 2003
    ..The identification of differentially expressed genes in the AGM region should yield further insights into the development of this tissue and into the emergence and regulation of HSCs...
  6. pmc Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells
    Mohammad B Hossain
    Department of Immunology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Immunology 125:377-86. 2008
    ..These results suggest that LEF-1 is involved in the GATA-3 complex, while also regulating the GATA-3 function, such as the induction of Th2 cytokine expression via the inhibition of the DNA-binding activity of GATA-3...
  7. pmc Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
    Krzysztof Kobielak
    Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021 6399, USA
    J Cell Biol 163:609-23. 2003
    ..In contrast, Lef1 is up-regulated, but its regulated control of hair differentiation is still blocked, and BMPRIA-null follicles fail ..
  8. ncbi Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections
    H Chen
    Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco 94243 0452, USA
    Neuron 25:43-56. 2000
    ..Our results show that neuropilin-2 is an essential component of the Sema3F receptor and identify key roles for neuropilin-2 in axon guidance in the PNS and CNS...
  9. ncbi Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells
    Zhe Xiong Jin
    Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    J Immunol 169:3783-92. 2002
    ..The link between LEF-1/beta-catenin and Wnt signaling in B lineage cells will be discussed...
  10. pmc Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin
    Jane Goodall
    Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Mol Cell Biol 24:2915-22. 2004
    ..These results, together with the observation that BRAF signaling also induces Brn-2 expression, reveal that Brn-2 is a focus for the convergence of two key melanoma-associated signaling pathways that are linked to cell proliferation...
  11. ncbi Wnt pathway component LEF1 mediates tumor cell invasion and is expressed in human and murine breast cancers lacking ErbB2 (her-2/neu) overexpression
    Anthony Nguyen
    Division of Hematology Oncology, University of California, Irvine, CA, USA
    Int J Oncol 27:949-56. 2005
    This study examines the role of LEF1, a component of the Wnt signaling pathway, in human breast and murine mammary carcinoma and its relationship to ErbB2 (her-2/neu) expression...
  12. ncbi Lef1 regulates COX-2 transcription in chondrocytes
    Kangsun Yun
    Department of Life Sciences, Gwangju Institute of Science and Technology GIST, 1 Oryong dong, Puk ku, Gwangju 500 712, Republic of Korea
    Biochem Biophys Res Commun 364:270-5. 2007
    ..Here, we demonstrate that lymphoid enhancer-binding factor 1 (Lef1) in concert with beta-catenin is associated with the transcriptional regulation of the gene encoding COX-2 in mouse ..
  13. pmc Runx2 and bone morphogenic protein 2 regulate the expression of an alternative Lef1 transcript during osteoblast maturation
    Luke H Hoeppner
    Graduate Program in Microbiology, Immunology and Cancer Biology, University of Minnesota, Minneapolis, MN, USA
    J Cell Physiol 221:480-9. 2009
    ..In this study, we describe the expression and function of an alternative Lef1 isoform in osseous cells...
  14. ncbi Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter
    Rachel A Kahler
    University of Minnesota Cancer Center, Department of Orthopaedic Surgery and Graduate Program in Microbiology, Immunology and Cancer Biology, Minneapolis, Minnesota 55455, USA
    J Biol Chem 278:11937-44. 2003
    ..A functional binding site for the high mobility group protein lymphoid enhancer-binding factor 1 (LEF1) was found adjacent to the proximal Runx2-binding site in the osteocalcin promoter...
  15. ncbi Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes
    Jacqueline M Veltmaat
    The Saban Research Institute of Childrens Hospital Los Angeles University of Southern California, Developmental Biology Program, Los Angeles, CA 90027, USA
    Development 133:2325-35. 2006
    ..We propose that the intra-somitic Fgf10 gradient, together with ventral elongation of the somites, determines the correct dorsoventral position of mammary epithelium along the flank...
  16. pmc Adenomatous polyposis coli (APC) is required for normal development of skin and thymus
    Mari Kuraguchi
    Harvard Partners Center for Genetics and Genomics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 2:e146. 2006
    ....
  17. ncbi LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]
    A Travis
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0414
    Genes Dev 5:880-94. 1991
    ..Moreover, forced expression of recombinant LEF-1 in late stage B cells increases TCR alpha enhancer function. Taken together, these data suggest that LEF-1 is a regulatory participant in lymphocyte gene expression and differentiation...
  18. ncbi Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate
    P Zhou
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA
    Genes Dev 9:700-13. 1995
    ..Collectively, our findings demonstrate that ectodermal expression of LEF-1 plays a central role in gene expression, pattern formation, and other developmental processes involving epithelial-mesenchymal associations...
  19. ncbi Structural basis for DNA bending by the architectural transcription factor LEF-1
    J J Love
    Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037, USA
    Nature 376:791-5. 1995
    ..The structure reveals the HMG domain bound in the widened minor groove of a markedly distorted and bent double helix. The basic region binds across the narrowed major groove and contributes to DNA recognition...
  20. ncbi Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions
    K Giese
    Howard Hughes Medical Institute, Department of Microbiology, University of California, San Francisco 94143 0414, USA
    Genes Dev 9:995-1008. 1995
    ....
  21. ncbi Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice
    C van Genderen
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0414
    Genes Dev 8:2691-703. 1994
    ..Together, the pattern of these defects suggest an essential role for LEF-1 in the formation of several organs and structures that require inductive tissue interactions...
  22. ncbi Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis
    M Oosterwegel
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Development 118:439-48. 1993
    ..Postnatally, expression of both genes could only be detected in lymphoid tissues. These observations suggest that TCF-1 and LEF-1 exert differential functions during murine embryogenesis...
  23. ncbi Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development
    K Kratochwil
    Howard Hughes Medical Institute, University of California, San Francisco, 94143, USA
    Genes Dev 10:1382-94. 1996
    ..organ development, formation of the epithelial primordium of the whisker but not tooth is dependent on mesenchymal Lef1 gene expression...
  24. ncbi Nuclear localization of beta-catenin by interaction with transcription factor LEF-1
    O Huber
    Department of Molecular Embryology, Max Planck Institute for Immunobiology, Freiburg, Germany
    Mech Dev 59:3-10. 1996
    ..As shown for beta-catenin, ectopic expression of LEF-1 in Xenopus embryos caused duplication of the body axis, indicating a regulatory role for a LEF-1-like molecule in dorsal mesoderm formation...
  25. ncbi Msx1 controls inductive signaling in mammalian tooth morphogenesis
    Y Chen
    Howard Hughes Medical Institute, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Development 122:3035-44. 1996
    ..Our results show that expression of Bone Morphogenetic Protein 4 (BMP4), the HMG box gene Lef1 and the heparan sulfate proteoglycan syndecan-1 is specifically reduced in Msx1 mutant dental mesenchyme, while ..
  26. ncbi Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1
    R M Okamura
    Howard Hughes Medical Institute, Department of Microbiology, University of California, San Francisco 94143 0414, USA
    Immunity 8:11-20. 1998
    ..Targeted gene disruption of either the Tcf1 or Lef1 gene in mice did not affect TCRalpha gene expression and resulted in an incomplete defect or no defect in thymocyte ..
  27. ncbi The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants
    Z Hardcastle
    Department of Craniofacial Development, UMDS, Guy s Hospital, London Bridge, London SE1 9RT, UK
    Development 125:2803-11. 1998
    ..These results show an essential role for Shh signalling in tooth development that involves functional redundancy of downstream Gli genes...
  28. ncbi Sonic hedgehog signaling is essential for hair development
    B St-Jacques
    Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1058-68. 1998
    ..To address the role of Shh in the hair follicle, we have examined Shh null mutant mice...
  29. pmc Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice
    J Galceran
    Howard Hughes Medical Institute and Departments of Microbiology and Biochemistry, University of California, San Francisco, California 94143, USA
    Genes Dev 13:709-17. 1999
    ..However, targeted gene inactivations of Lef1, Tcf1, or Tcf4 in the mouse do not produce phenotypes that mimic any known Wnt mutation...
  30. ncbi Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1)
    D Duan
    Department of Anatomy and Cell Biology and Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Development 126:4441-53. 1999
    Previous studies have demonstrated that transcription of the lymphoid enhancer binding factor 1 (Lef1) gene is upregulated in submucosal gland progenitor cells just prior to gland bud formation in the developing ferret trachea...
  31. ncbi Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
    R Dasgupta
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology and Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
    Development 126:4557-68. 1999
    ..mice, TOPGAL expression was directly stimulated by a stabilized form of beta -catenin, but was also dependent upon LEF1/TCF3 in skin...
  32. ncbi Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1
    J Galceran
    Howard Hughes Medical Institute, Department of Microbiology, University of California, San Francisco, CA 94143, USA
    Development 127:469-82. 2000
    b>Lef1 and other genes of the LEF1/TCF family of transcription factors are nuclear mediators of Wnt signaling. Here we examine the expression pattern and functional importance of Lef1 in the developing forebrain of the mouse...
  33. ncbi Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism
    T Reya
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, 94143, USA
    Immunity 13:15-24. 2000
    ..We further show that Lef1-/- pro-B cells display elevated levels of fas and c-myc transcription, providing a potential mechanism for their ..
  34. ncbi Sonic hedgehog regulates growth and morphogenesis of the tooth
    H R Dassule
    Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
    Development 127:4775-85. 2000
    ..However, the enamel knot, a putative organizer of crown formation, is present and expresses Fgf4, Wnt10b, Bmp2 and Lef1, as in the wild type...
  35. ncbi Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development
    J Foley
    Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA
    Development 128:513-25. 2001
    ..Finally, PTHrP signaling regulates the epidermal and mesenchymal expression of LEF1 and (&bgr;)-catenin, suggesting that these changes in cell fate involve an interaction between the PTHrP and ..
  36. ncbi beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13092, Berlin, Germany
    Cell 105:533-45. 2001
    ..Further analysis demonstrates that beta-catenin is essential for fate decisions of skin stem cells: in the absence of beta-catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate...
  37. pmc Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression
    J Galceran
    Gene Center and Institute of Biochemistry, University of Munich, Feodor Lynenstrasse 25, 81377 Munich, Germany
    Proc Natl Acad Sci U S A 98:8668-73. 2001
    ..Consistent with this view, mice carrying mutations in either the Wnt3a gene or in both transcription factor genes Lef1 and Tcf1 were previously found to show a similar defect in the formation of paraxial mesoderm in the gastrulating ..
  38. ncbi Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung
    M Tebar
    Department of Pulmonology, Leiden University Medical Center, NL 2300 RC, Leiden, The Netherlands
    Mech Dev 109:437-40. 2001
    ..5 onward), and adjacent mesenchyme. Tcf1, Lef1, Tcf3, Tcf4, sFrp1, sFrp2 and sFrp4 were also expressed in the PE, AE, and adjacent mesenchyme in specific spatio-..
  39. ncbi Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo
    Arnaud André Mailleux
    UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Development 129:53-60. 2002
    ..We have investigated the molecular mechanisms of mammary placode development using Lef1 as a marker for the epithelial component of the placode, and mice deficient for Fgf10 or Fgfr2b, both of which fail ..
  40. ncbi Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
    Catherin Niemann
    Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 129:95-109. 2002
    To examine the consequences of repressing beta-catenin/Lef1 signalling in mouse epidermis, we expressed a DeltaNLef1 transgene, which lacks the beta-catenin binding site, under the control of the keratin 14 promoter...
  41. ncbi Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar
    Johanna Laurikkala
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Development 129:2541-53. 2002
    ..and hair follicles, we analyzed the expression and regulation of Eda and Edar in wild type as well as Tabby and Lef1 mutant mouse embryos...
  42. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
    ..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation...
  43. ncbi Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4
    Andreas Hecht
    Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108 Freiburg, Germany
    J Biol Chem 278:3776-85. 2003
    ..We found that TCF4E but not LEF1 supported beta-catenin-dependent activation of the Cdx1 promoter, whereas LEF1 specifically activated the Siamois ..
  44. pmc Links between signal transduction, transcription and adhesion in epithelial bud development
    Colin Jamora
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Nature 422:317-22. 2003
    ..signals: a Wnt protein to stabilize beta-catenin, and a bone morphogenetic protein (BMP) inhibitor to produce Lef1. Beta-catenin then binds to, and activates, Lef1 transcription complexes that appear to act uncharacteristically by ..
  45. ncbi Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2
    Samer M Hussein
    Brain Tumor Research Center, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 278:48805-14. 2003
    ..is mediated via the cooperative binding of Smad4 at two Smad binding elements and of lymphoid enhancing factor (Lef1) at two Lef1/TCF binding sites...
  46. ncbi Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities
    Cheng Ji Zhou
    Department of Neurology, Programs in Neuroscience and Developmental Biology, University of California, San Francisco, California 94143 0435, USA
    J Neurosci 24:121-6. 2004
    ..2000). We examined the hippocampal phenotype of single LRP6 mutant mice as well as LRP6/Lef1 double mutant mice...
  47. ncbi PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter
    Usha Vadlamudi
    Department of Biological Science, The University of Tulsa, 600 S College Ave, Tulsa, OK 74104 3189, USA
    J Cell Sci 118:1129-37. 2005
    ..LEF-1 and beta-catenin interactions with PITX2 provide new mechanisms for the regulation of PITX2 transcriptional activity...
  48. ncbi Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland
    Kata Boras-Granic
    Department of Laboratory Medicine and Pathobiology, 6318 Medical Sciences Building, 1 King s College Road, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Dev Biol 295:219-31. 2006
    ..b>Lef1-mediated canonical Wnt signaling is required for morphogenesis of these skin appendages during embryogenesis...
  49. pmc Lhx2 maintains stem cell character in hair follicles
    Horace Rhee
    Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021
    Science 312:1946-9. 2006
    ..Using gain- and loss-of-function studies, we uncovered a role for Lhx2 in maintaining the growth and undifferentiated properties of hair follicle progenitors...
  50. ncbi Dynamic expression of Runx1 in skin affects hair structure
    Eli Raveh
    Department of Cell and Animal Biology, Silberman Life Sciences Institute, Edmond Safra Campus at Givat Ram, The Hebrew University, Jerusalem 91904, Israel
    Mech Dev 123:842-50. 2006
    ..The data delineate Runx1 as a novel specific marker of several hair follicle cell types and sheds light on its role in hair morphogenesis and differentiation...
  51. ncbi Mapping canonical Wnt signaling in the developing and adult retina
    Hong Liu
    Molecular Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada
    Invest Ophthalmol Vis Sci 47:5088-97. 2006
    ..This study was undertaken to characterize activation of the Wnt canonical pathway and its relevance to cell type populations in the developing and adult retina...
  52. pmc Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development
    Kyoung Won Cho
    Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea21 Project, College of Dentistry, Yonsei Center of Biotechnology, Yonsei University, Seoul 120 752, Korea
    Proc Natl Acad Sci U S A 103:16788-93. 2006
    ..In addition, when BMP signaling was inhibited by NOGGIN, Lef1 expression was lost...
  53. pmc Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling
    Elina Järvinen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, P O Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 103:18627-32. 2006
    ..These results may implicate Wnt signaling in tooth renewal, a capacity that was all but lost when mammals evolved progressively more complicated tooth shapes...
  54. ncbi Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
    Marie Liesse Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Cell Biol 9:201-9. 2007
    ..These studies provide evidence for the existence of an epithelial hierarchy within the mammary gland and establish Gata-3 as a critical regulator of luminal differentiation...
  55. pmc Wnt signaling interacts with Shh to regulate taste papilla development
    Ken Iwatsuki
    Department of Neuroscience, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 104:2253-8. 2007
    ..The elimination of Wnt/beta-catenin signaling in either Lef1 or Wnt10b knockout mice resulted in down-regulation of Shh expression...
  56. pmc Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis
    Ryan R Driskell
    Department of Anatomy and Cell Biology, Iowa City, IA 52242, USA
    Dev Biol 305:90-102. 2007
    ..These findings provide the first in vivo evidence that Wnt3a can transcriptionally regulate the Lef-1 gene...
  57. ncbi Wnt signaling mediates regional specification in the vertebrate face
    Samantha A Brugmann
    Department of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305, USA
    Development 134:3283-95. 2007
    ..Mice carrying compound null mutations in the nuclear mediators Lef1 and Tcf4 exhibited radically altered facial features that culminated in a hyperteloric appearance and a ..
  58. pmc Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis
    Fei Liu
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Biol 313:210-24. 2008
    ....
  59. pmc Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen
    Sanhita Ray
    Division of Reproductive and Developmental Biology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Mol Endocrinol 22:1125-40. 2008
    ..Collectively, these studies support a mechanism that integration of a nonclassically induced beta-catenin/Lef-1/Tcf-3 signaling with ERalpha is necessary for estrogen-dependent endogenous gene regulation in uterine biology...
  60. doi Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary
    Anne Amandine Chassot
    INSERM, U636, F 06108 Nice, France
    Hum Mol Genet 17:1264-77. 2008
    ..Thus, a balance between Sox9 and beta-catenin activation determines the fate of the gonad, with Rspo1 acting as a crucial regulator of canonical beta-catenin signaling required for female development...
  61. pmc An FGF-WNT gene regulatory network controls lung mesenchyme development
    Yongjun Yin
    Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 319:426-36. 2008
    ..Together, both FGF and WNT signaling pathways function to sustain mesenchymal growth and coordinate epithelial morphogenesis during the pseudoglandular stage of lung development...
  62. pmc TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner
    Hu Zhao
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 320:19-29. 2008
    ..There is an intrinsic requirement for Alk5 signal in regulating the fate of CNC cells during tooth and mandible development...
  63. pmc Dlx3 is a crucial regulator of hair follicle differentiation and cycling
    Joonsung Hwang
    Developmental Skin Biology Unit, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:3149-59. 2008
    ....
  64. doi RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis
    Kosei Ito
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673
    Cancer Cell 14:226-37. 2008
    ..Taken together, these data demonstrate that RUNX3 functions as a tumor suppressor by attenuating Wnt signaling...
  65. pmc Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction
    Yuhang Zhang
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Cell 17:49-61. 2009
    ..These data reveal a complex interplay and interdependence of Wnt/beta-catenin and EDA/EDAR/NF-kappaB signaling pathways in initiation and maintenance of primary hair follicle placodes...
  66. pmc Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development
    Jianquan Chen
    Department of Biology, University of Rochester, Rochester, New York 14642, USA
    Dev Biol 334:174-85. 2009
    ..We show that mesenchymal beta-catenin function is required for expression of Lef1 and Fgf3 in the developing tooth mesenchyme and for induction of primary enamel knot in the developing tooth ..
  67. doi Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion
    Lanying Song
    Department of Cell Biology and Human Anatomy, University of California, Davis, CA 95616, USA
    Development 136:3161-71. 2009
    ..Thus, the Lrp6-mediated Wnt signaling pathway is required for lip development by orchestrating two distinctively different morphogenetic movements...
  68. pmc Differential activity of Wnt/beta-catenin signaling in the embryonic mouse thalamus
    Krista K Bluske
    Department of Neuroscience, and Graduate Program in Neuroscience, Minneapolis, Minnesota 55455, USA
    Dev Dyn 238:3297-309. 2009
    ..Analysis of mice with enhanced or reduced Shh signal showed that Axin2 expression is similar to controls. These results suggest that differential Wnt signaling may play a role in patterning the thalamus independent of Shh signaling...
  69. doi LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain
    Marta B Wisniewska
    International Institute of Molecular and Cell Biology, 02 109 Warsaw, Poland
    J Neurosci 30:4957-69. 2010
    beta-Catenin, together with LEF1/TCF transcription factors, activates genes involved in the proliferation and differentiation of neuronal precursor cells...
  70. pmc MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression
    Zichao Zhang
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 285:34718-28. 2010
    ..This study demonstrates that microRNAs are critical for anterior pituitary development and that miR-26b regulates Pit-1 expression by inhibiting Lef-1 expression and may promote Pit-1 lineage differentiation during pituitary development...
  71. pmc Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6
    Danielle Matsushima
    UNC Neuroscience Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Development 138:443-54. 2011
    ..Collectively, these results demonstrate that precise regulation of the ratio of SOX2 to PAX6 is necessary to ensure accurate progenitor cell specification, and place SOX2 as a decisive factor of neural competence in the retina...
  72. pmc Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis
    Katherine A Fantauzzo
    Department of Dermatology, Columbia University, New York, NY 10032, USA
    Development 139:203-14. 2012
    ..Our findings identify Trps1 as a novel regulator of the Wnt signaling pathway and of early hair follicle progenitors in the developing vibrissa follicle...
  73. pmc Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation
    Demeng Chen
    Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 139:1522-33. 2012
    ..These data reveal functional roles for dermal Wnt signaling/β-catenin in fibroblast proliferation and in the epidermal hair follicle initiation program...
  74. pmc The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy
    Shuyang Yu
    Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Immunity 37:813-26. 2012
    ..that TCF-1 directly repressed LEF-1 expression in early thymocytes and that conditional inactivation of Lef1 greatly delayed or prevented T cell malignancy in Tcf7(-/-) mice...
  75. pmc FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice
    Klaus Kratochwil
    Institute of Molecular Biology, Austrian Academy of Sciences, 5020 Salzburg, Austria
    Genes Dev 16:3173-85. 2002
    Lymphoid enhancer factor (LEF1), a nuclear mediator of Wnt signaling, is required for the formation of organs that depend on inductive interactions between epithelial and mesenchymal tissues...
  76. ncbi Activation of mouse RAG-2 promoter by Myc-associated zinc finger protein
    Chun Xiao Wu
    Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630, Sugitani, Toyama 930 0194, Japan
    Biochem Biophys Res Commun 317:1096-102. 2004
    ..Furthermore, we show that MAZ synergistically activates the murine RAG-2 promoter with Pax-5/c-Myb/LEF-1 complex. These results first demonstrate that MAZ participates in activation of mouse RAG-2 promoter...
  77. ncbi LEF1 is a critical epithelial survival factor during tooth morphogenesis
    Tomoyo Sasaki
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 278:130-43. 2005
    b>LEF1 is a cell-type-specific transcription factor and mediates Wnt signaling pathway by association with its co-activator beta-catenin...
  78. ncbi Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts
    Rachel A Kahler
    Graduate Program in Microbiology, Immunology and Cancer Biology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Cell Biochem 97:969-83. 2006
    b>Lef1 is a transcriptional regulator of the Wnt/beta-catenin signaling cascade. Wnts directly augment bone formation and osteoblast differentiation from mesenchymal stem cells by receptor-mediated pathways involving Lrp5 and Frizzled...
  79. ncbi Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    Donald A Glass
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
    Dev Cell 8:751-64. 2005
    ....
  80. pmc Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme
    Minoti Hiremath
    Department of Biological Sciences, Boise State University, Boise, ID 83725, USA
    Development 139:4239-49. 2012
    ..differentiation of the ventral epidermis into nipple-like skin and is accompanied by ectopic expression of Lef1, β-catenin and other markers of the mammary mesenchyme...
  81. ncbi Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants
    J A Cygan
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
    Development 124:5021-32. 1997
    ..Unlike the normal AER, ectopic AER formation is dependent upon Wnt-7a activity, indicating that distinct genetic mechanisms may be involved in primary and secondary AER formation...
  82. ncbi Alx-4, a transcriptional activator whose expression is restricted to sites of epithelial-mesenchymal interactions
    R Hudson
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Dev Dyn 213:159-69. 1998
    ..Taken together, our results demonstrate that Alx-4 is a potent transcriptional activator that is expressed at sites of epithelial-mesenchymal interactions during murine embryonic development...
  83. ncbi CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury
    Kameswaran Surendran
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Renal Physiol 284:F653-62. 2003
    ..These findings suggest that Wnt-4 stimulates Nppc in a TCF/LEF-dependent manner after renal injury and thus may contribute to limiting renal fibrosis...
  84. ncbi Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
    David A Cano
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 131:3457-67. 2004
    ..Thus, polaris and primary cilia function are required for the maturation and maintenance of proper tissue organization in the pancreas...
  85. pmc Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification
    Beatrice Howard
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, United Kingdom
    Genes Dev 19:2078-90. 2005
    ..Finally, Neuregulin3 (Nrg3)-soaked beads can induce expression of the early bud marker Lef1 in mouse embryo explant cultures, and epithelial bud formation can be observed histologically, suggesting that ..
  86. ncbi Gene expression analysis of myeloid and lymphoid lineage markers during mouse haematopoiesis
    E Sakhinia
    Division of Laboratory and Regenerative Medicine, School of Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK
    Br J Haematol 135:105-16. 2006
    ..To overcome this, the expression profile of lymphoid and myeloid-associated genes (LEF1, EBF, CD19, Sox-4, B29, CD45, C-fms, lysozyme, PU...
  87. ncbi Transcription factor epiprofin is essential for tooth morphogenesis by regulating epithelial cell fate and tooth number
    Takashi Nakamura
    Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    J Biol Chem 283:4825-33. 2008
    ..Thus, Epfn has multiple functions for cell fate determination of the dental epithelium by regulating both proliferation and differentiation, preventing continuous tooth budding and generation...
  88. pmc The apical ectodermal ridge is a timer for generating distal limb progenitors
    Pengfei Lu
    Department of Anatomy and Program in Developmental Biology, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Development 135:1395-405. 2008
    ..Taken together, we have uncovered a novel mechanism, whereby the AER regulates the number of autopod progenitors by determining the onset of their generation...
  89. doi Dynamic expression of Syndecan-1 during hair follicle morphogenesis
    Gavin D Richardson
    School of Biological and Biomedical Sciences, Durham University, Durham DH1 3LE, UK
    Gene Expr Patterns 9:454-60. 2009
    ..Furthermore we show by using gene targeted mice lacking Syndecan-1 expression that Syndecan-1 is not required for follicle initiation and development...
  90. doi Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development
    Dai Suzuki
    Department of Biochemistry, Showa University, Hatanodai, Shinagawa, Tokyo, Japan
    Dev Biol 335:396-406. 2009
    ..Our findings from Rac1 conditional mutants indicate crucial roles for Rac1 in limb bud morphogenesis, especially interdigital programmed cell death...
  91. doi Lymphoid enhancer binding factor 1 regulates transcription through gene looping
    Kangsun Yun
    Department of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Korea
    J Immunol 183:5129-37. 2009
    ..We have previously shown that IL-1beta-induced lymphoid enhancer binding factor 1 (Lef1) regulates the transcription of its target genes COX2 and MMP13 in mouse chondrocytes by ..
  92. pmc Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha
    Rose Anne Romano
    Department of Biochemistry, Center for Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA
    Development 137:1431-9. 2010
    ..Our data provide evidence supporting a role for DeltaNp63alpha in actively suppressing hair follicle differentiation and directing IFE cell lineage commitment...
  93. doi Beta-catenin/LEF1 activated enamelin expression in ameloblast-like cells
    Hua Tian
    Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China
    Biochem Biophys Res Commun 398:519-24. 2010
    ..However, mechanisms of enamelin transcription regulation are not clear. beta-Catenin/LEF1 is a key transcriptional complex involved in tooth development...
  94. doi Wnt/β-catenin signaling is disrupted in the extra-toes (Gli3(Xt/Xt) ) mutant from early stages of forebrain development, concomitant with anterior neural plate patterning defects
    Vassiliki Fotaki
    Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Comp Neurol 519:1640-57. 2011
    ..Our data reveal that Gli3 is required at the neural plate stage to regulate Wnt expression and Wnt/β-catenin signaling in the presumptive forebrain and confirm its previously proposed role in patterning the anterior neural plate...
  95. pmc Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments
    Karen M Osorio
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 193:235-50. 2011
    ..The latter involves Lef1 and Wnt signaling modulation in opposing directions from two distinct skin compartments...
  96. ncbi Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth
    H R Dassule
    The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Biol 202:215-27. 1998
    ..For example, epithelially expressed Bmp4 induces Msx1 and Lef1 as well as itself in the underlying mesenchyme...
  97. ncbi PDGF-A and PDGFR-alpha regulate tooth formation via autocrine mechanism during mandibular morphogenesis in vitro
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033, USA
    Dev Dyn 213:500-11. 1998
    ..These data suggest that PDGF-A and its cognate receptor (PDGFR-alpha) regulate the size and stage of tooth development via an autocrine mechanism during odontogenesis in vitro...
  98. ncbi Gene expression patterns associated with suppression of odontogenesis in mouse and vole diastema regions
    S V Keränen
    Developmental Biology Program, Institute of Biotechnology, Biocenter 1, University of Helsinki, P O Box 56, Helsinki, FIN 00014, Finland
    Dev Genes Evol 209:495-506. 1999
    ..tooth germs we compared the expression patterns of several developmental regulatory genes (Bmp2, Bmp4, Fgf4, Fgf8, Lef1, Msx1, Msx2, p21, Pitx2, Pax9 and Shh) between molars and diastema buds of mice and voles...
  99. ncbi Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ
    X Zhao
    Department of Cell and Molecular Biology and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Mech Dev 99:29-38. 2000
    ..Expression of Shh and Bmp2 in the enamel knot may not represent critical signals for tooth patterning...
  100. pmc The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation
    Baoan Li
    Department of Biological Chemistry, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 99:6064-9. 2002
    ..Additionally, we show that the movo1 promoter is activated by the lymphoid enhancer factor 1 (LEF1)/beta-catenin complex, a transducer of wnt signaling...
  101. ncbi Lymphoid enhancer factor-1 blocks adenomatous polyposis coli-mediated nuclear export and degradation of beta-catenin. Regulation by histone deacetylase 1
    Beric R Henderson
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, New South Wales 2145, Australia
    J Biol Chem 277:24258-64. 2002
    ..beta-catenin in the nucleus was down-regulated by histone deacetylase 1, and this correlated with a decrease in LEF1 transcription activity...

Research Grants3

  1. MECHANISMS OF RAAV TRANSDUCTION IN THE AIRWAY
    JOHN ENGELHARDT; Fiscal Year: 2008
    ..Further elucidation of rAAV transduction biology in the airway will aid in the development of clinically applicable methods for increasing the efficacy of rAAV gene transfer in vivo. ..
  2. Redox-mediated NF-kappaB activation by LPS and IL-1
    JOHN ENGELHARDT; Fiscal Year: 2008
    ..Findings from these studies may lead to alternative therapeutic approaches targeting the liver by which to abrogate the detrimental effects of systemic cytokine production during sepsis. ..
  3. ROLES OF SOX C GENES IN SKELETOGENESIS
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010
    ....