Lhx2

Summary

Gene Symbol: Lhx2
Description: LIM homeobox protein 2
Alias: LH2A, Lh-2, Lim2, apterous, LIM/homeobox protein Lhx2, LIM homeo box protein 2, homeobox protein LH-2
Species: mouse

Top Publications

  1. pmc LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells
    Y Xu
    Howard Hughes Medical Institute, Children s Hospital, Boston, MA
    Proc Natl Acad Sci U S A 90:227-31. 1993
  2. doi Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression
    Ken ichiro Kuwako
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neuron 67:407-21. 2010
  3. pmc Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1
    Ying Qian
    The Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:1220-33. 2002
  4. ncbi Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons
    M P Matise
    New York University Medical School, Skirball Institute of Biomolecular Medicine, Developmental Genetics Program, New York, New York 10016, USA
    J Neurosci 17:7805-16. 1997
  5. ncbi Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons
    S A Anderson
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143, USA
    Neuron 19:27-37. 1997
  6. pmc FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation
    Kimberly A Aldinger
    Committee on Neurobiology, University of Chicago, Chicago, Illinois, USA
    Nat Genet 41:1037-42. 2009
  7. ncbi A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins
    I Bach
    Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648, USA
    Genes Dev 11:1370-80. 1997
  8. ncbi Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development
    F D Porter
    Heritable Disorders Branch, National Institutes of Health, Bethesda, MD 20892, USA
    Development 124:2935-44. 1997
  9. ncbi Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity
    A J Bendall
    Center for Advanced Biotechnology and Medicine, Piscataway, NJ 08854, USA
    Differentiation 63:151-7. 1998
  10. ncbi Mash1 regulates neurogenesis in the ventral telencephalon
    S Casarosa
    IGBMC, CNRS INSERM Universite Louis Pasteur, BP 163, CU de Strasbourg, France
    Development 126:525-34. 1999

Research Grants

Scientific Experts

Detail Information

Publications122 found, 100 shown here

  1. pmc LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells
    Y Xu
    Howard Hughes Medical Institute, Children s Hospital, Boston, MA
    Proc Natl Acad Sci U S A 90:227-31. 1993
    ..LH-2 protein is related to that of other LIM/homeodomain proteins, most strikingly with that of the Drosophila apterous protein. Expression of LH-2 was found in B- and T-lymphoid cell lines...
  2. doi Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression
    Ken ichiro Kuwako
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neuron 67:407-21. 2010
    ..Together, these findings indicate that Msi1-mediated posttranscriptional regulation of Robo3 controls midline crossing of precerebellar neurons...
  3. pmc Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1
    Ying Qian
    The Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:1220-33. 2002
    ..Together, our studies demonstrate a central role for Rnx and Tlx-1 in the development of two major classes of relay sensory neurons, somatic and visceral...
  4. ncbi Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons
    M P Matise
    New York University Medical School, Skirball Institute of Biomolecular Medicine, Developmental Genetics Program, New York, New York 10016, USA
    J Neurosci 17:7805-16. 1997
    ..Rather, it is suggested that En-1 may function to distinguish a subset of interneurons during the later maturation of the spinal cord...
  5. ncbi Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons
    S A Anderson
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143, USA
    Neuron 19:27-37. 1997
    ..Several lines of evidence suggest that mutations in Dlx-1 and Dlx-2 produce abnormalities in the development of the striatal subventricular zone and in the differentiation of striatal matrix neurons...
  6. pmc FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation
    Kimberly A Aldinger
    Committee on Neurobiology, University of Chicago, Chicago, Illinois, USA
    Nat Genet 41:1037-42. 2009
    ..Our results highlight a previously unrecognized role for mesenchyme-neuroepithelium interactions in the mid-hindbrain during early embryogenesis...
  7. ncbi A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins
    I Bach
    Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648, USA
    Genes Dev 11:1370-80. 1997
    ..Our results link LIM homeodomain proteins and members of the Otx class of transcription factors in gene activation events during embryogenesis via the actions of specific cofactors...
  8. ncbi Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development
    F D Porter
    Heritable Disorders Branch, National Institutes of Health, Bethesda, MD 20892, USA
    Development 124:2935-44. 1997
    We investigated the function of Lhx2, a LIM homeobox gene expressed in developing B-cells, forebrain and neural retina, by analyzing embryos deficient in functional Lhx2 protein...
  9. ncbi Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity
    A J Bendall
    Center for Advanced Biotechnology and Medicine, Piscataway, NJ 08854, USA
    Differentiation 63:151-7. 1998
    ..Here we show that Lhx2, a LIM-type homeoprotein, is a protein partner for Msx1 in vitro and in cellular extracts...
  10. ncbi Mash1 regulates neurogenesis in the ventral telencephalon
    S Casarosa
    IGBMC, CNRS INSERM Universite Louis Pasteur, BP 163, CU de Strasbourg, France
    Development 126:525-34. 1999
    ..Therefore, Mash1 is an important regulator of neurogenesis in the ventral telencephalon, where it is required both to specify neuronal precursors and to control the timing of their production...
  11. ncbi Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain
    S Retaux
    Laboratoire de Neurochimie Anatomie, Institut des Neurosciences, 75005 Paris, France
    J Neurosci 19:783-93. 1999
    ..Lhx9 cDNA encodes a protein that is most closely related to Drosophila apterous and rodent Lhx2 proteins...
  12. ncbi BMP7 acts in murine lens placode development
    S Wawersik
    Division of Genetics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Dev Biol 207:176-88. 1999
    ..We conclude that Bmp7 is a critical component of the genetic mechanism(s) controlling lens placode formation...
  13. pmc Conservation of the expression and function of apterous orthologs in Drosophila and mammals
    D E Rincon-Limas
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 96:2165-70. 1999
    The Drosophila apterous (ap) gene encodes a protein of the LIM-homeodomain family...
  14. ncbi Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5
    Y Zhao
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Science 284:1155-8. 1999
    ..Lhx5 is therefore essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development...
  15. ncbi Characterization of Lhx9, a novel LIM/homeobox gene expressed by the pioneer neurons in the mouse cerebral cortex
    S Bertuzzi
    Laboratory of Mammalian Genes and Development, NICHD, NIH, Bethesda, MD, USA
    Mech Dev 81:193-8. 1999
    In order to explain the phenotype observed in Lhx2 mutant embryos, we previously proposed that an Lhx2 related gene might exist. We now have cloned a new LIM/homeobox gene called Lhx9...
  16. ncbi MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression
    D J Glenn
    Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 274:36159-67. 1999
    ..designated the pituitary glycoprotein basal element, which interacts with the LIM homeodomain transcription factor, Lhx2. In the present studies we have explored the function of the LIM domain of Lhx2 in stimulating alpha-subunit ..
  17. ncbi LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem
    S Bulchand
    Department of Biological Sciences, Tata Institute of Fundamental Research, 400005, Mumbai, India
    Mech Dev 100:165-75. 2001
    ..Mice in which Lhx2 is disrupted were reported to have reduced telencephalic development, and the hippocampal primordium appeared to be ..
  18. ncbi Combinatorial expression patterns of LIM-homeodomain and other regulatory genes parcellate developing thalamus
    Y Nakagawa
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 21:2711-25. 2001
    ..We have defined a set of regulatory genes, which include five LIM-homeodomain transcription factors (Isl1, Lhx1, Lhx2, Lhx5, and Lhx9) and three other genes (Gbx2, Ngn2, and Pax6), that are differentially expressed in dTh and vTh of ..
  19. ncbi Proprioceptor pathway development is dependent on Math1
    N A Bermingham
    Howard Hughes Medical Institute, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 30:411-22. 2001
    ..We also identify three downstream genes of Math1 (Lh2A, Lh2B, and Barhl1) and establish that Math1 governs the development of multiple components of the proprioceptive ..
  20. ncbi Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway
    E S Monuki
    Division of Neurogenetics, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neuron 32:591-604. 2001
    ..Here we show that cortical patterning involves regulation of the Lhx2 homeobox gene by the roof plate...
  21. ncbi BMP ligands act redundantly to pattern the dorsal telencephalic midline
    Jean M Hebert
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Genesis 35:214-9. 2003
    ....
  22. ncbi A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons
    Samantha J Butler
    Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 38:389-401. 2003
    ..Our findings suggest that a GDF7:BMP7 heterodimer functions as a roof plate-derived repellent that establishes the initial ventral trajectory of commissural axons...
  23. ncbi Neurogenin2 specifies the connectivity of thalamic neurons by controlling axon responsiveness to intermediate target cues
    Julie Seibt
    INSERM U371, 18 Avenue Doyen Lepine, 69675 Bron, France
    Neuron 39:439-52. 2003
    ..Our results thus demonstrate that in parallel to their well-documented proneural function, bHLH transcription factors also contribute to the specification of neuronal connectivity in the mammalian brain...
  24. ncbi Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disrupted
    Aditee Vyas
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    J Comp Neurol 466:545-53. 2003
    ..In the Lhx2-/- telencephalon, where the cortex is greatly shrunken such that medial and dorsal cortical tissue is undetectable, ..
  25. ncbi Lhx2 expression in hematopoietic progenitor/stem cells in vivo causes a chronic myeloproliferative disorder and altered globin expression
    Karin Richter
    Umeå Center for Molecular Medicine, Umea University, 901 87 Umea, Sweden
    Haematologica 88:1336-47. 2003
    ..This translocation has also been suggested to cause mis-expression of the LIM-homeobox gene Lhx2 in hematopoietic cells...
  26. pmc The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons
    Junji Hirota
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:8751-5. 2004
    ..Here, using the yeast one-hybrid system and electrophoretic mobility shift assay, we report that Lhx2, a LIM-homeodomain protein, binds to the homeodomain site in the mouse M71 OR promoter region...
  27. pmc Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways
    Carol Schuurmans
    IGBMC, Illkirch, CU de Strasbourg, France
    EMBO J 23:2892-902. 2004
    ..Our study thus reveals an unanticipated heterogeneity in the genetic mechanisms specifying the identity of neocortical projection neurons...
  28. ncbi EMX2 regulates sizes and positioning of the primary sensory and motor areas in neocortex by direct specification of cortical progenitors
    Tadashi Hamasaki
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 43:359-72. 2004
    ..We conclude that EMX2 levels in cortical progenitors disproportionately specify sizes and positions of primary cortical areas...
  29. ncbi The Lim homeobox gene Lhx2 is required for olfactory sensory neuron identity
    Asa Kolterud
    Department of Molecular Biology, Umea University, Umea, SE901 87, Sweden
    Development 131:5319-26. 2004
    ..We show that progenitors and neurons express the LIM-homeobox gene Lhx2 and that neurons in Lhx2-null mutant embryos do not diversify into subpopulations expressing different OR genes and ..
  30. pmc Global gene expression analyses of hematopoietic stem cell-like cell lines with inducible Lhx2 expression
    Karin Richter
    Umeå Center for Molecular Medicin, Umea Universitet, 90187 Umea, Sweden
    BMC Genomics 7:75. 2006
    Expression of the LIM-homeobox gene Lhx2 in murine hematopoietic cells allows for the generation of hematopoietic stem cell (HSC)-like cell lines...
  31. pmc Lhx2 maintains stem cell character in hair follicles
    Horace Rhee
    Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021
    Science 312:1946-9. 2006
    ..We identified Lhx2 as a transcription factor positioned downstream of signals necessary to specify hair follicle stem cells, but ..
  32. ncbi Central roles of the roof plate in telencephalic development and holoprosencephaly
    Xun Cheng
    Department of Pathology and Laboratory Medicine, University of California Irvine School of Medicine, 92697 4800, USA
    J Neurosci 26:7640-9. 2006
    ..These findings establish selective roles for roof plate-dependent Bmp signaling in dorsal telencephalic patterning and HPE and define novel candidate genes for the human disorder...
  33. pmc Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells
    Xiaoman Xu
    Department of Medicine, Division of Endocrinology, Sprague Hall, Room 206, University of California, Irvine, Irvine, CA 92697 4030, USA
    Dev Biol 312:484-500. 2007
    ..In addition, Clim2 interacts with Lhx2 in vivo, suggesting that Clim2 is an essential co-factor for the LIM homeodomain factor Lhx2, which was previously ..
  34. pmc Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate
    Vishakha S Mangale
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Science 319:304-9. 2008
    ..Using mouse genetic mosaics and timed inactivations, we demonstrated that Lhx2 acts as a classic selector gene and essential intrinsic determinant of cortical identity...
  35. pmc Lhx2 expression promotes self-renewal of a distinct multipotential hematopoietic progenitor cell in embryonic stem cell-derived embryoid bodies
    Lina Dahl
    Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    PLoS ONE 3:e2025. 2008
    ..The LIM-homeobox gene Lhx2 is a candidate regulator of fetal hematopoiesis since it is expressed in the fetal liver and Lhx2(-/-) mice die in ..
  36. pmc Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex
    Alessandro Sessa
    Molecular Neuropathology Laboratory, SCRI, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Neuron 60:56-69. 2008
    ..Together, these findings identify Tbr2 as a critical factor for the specification of IPCs during corticogenesis...
  37. doi The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation
    Nicolas Tétreault
    Developmental Biology Laboratory, Maisonneuve Rosemont Hospital, 5415 Boulevard l Assomption, Montreal, Canada, H1T 2M4
    Dev Biol 327:541-50. 2009
    ..We found that the Lhx2 and Pax6 transcription factors operate in a concerted manner during retinal development to promote transcriptional ..
  38. pmc Cyclic expression of lhx2 regulates hair formation
    Gunilla Törnqvist
    Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    PLoS Genet 6:e1000904. 2010
    ..The transcriptional regulation of this process is not well understood. We show that the transcription factor Lhx2 is expressed in cells of the outer root sheath and a subpopulation of matrix cells during both morphogenesis and ..
  39. pmc Lmx1a regulates fates and location of cells originating from the cerebellar rhombic lip and telencephalic cortical hem
    Victor V Chizhikov
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:10725-30. 2010
    ..Thus, Lmx1a activity is critical for proper production of cells originating from both the cerebellar rhombic lip and the telencephalic cortical hem...
  40. pmc Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord
    K J Lee
    Howard Hughes Medical Institute HHMI, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032 USA
    Genes Dev 12:3394-407. 1998
    ..More generally, these results suggest that BMP signaling may have a prominent role in the assignment of neuronal identity within the mammalian CNS...
  41. ncbi Hematopoietic progenitor/stem cells immortalized by Lhx2 generate functional hematopoietic cells in vivo
    Perpétua Pinto do Ó
    Department of Molecular Biology, Umea University, Sweden
    Blood 99:3939-46. 2002
    ..We have previously shown that expression of the LIM-homeobox gene Lhx2 in hematopoietic progenitor cells derived from embryonic stem cells differentiated in vitro generates immortalized ..
  42. ncbi Lhx2 is expressed in the septum transversum mesenchyme that becomes an integral part of the liver and the formation of these cells is independent of functional Lhx2
    Asa Kolterud
    Umeå Centre for Molecular Medicine, Umea University, 901 87 Umea, Sweden
    Gene Expr Patterns 4:521-8. 2004
    ..Targeted disruption of the LIM-homeobox gene Lhx2 has revealed that it is important for the expansion of the liver during embryonic development, whereas it appears ..
  43. pmc Lhx2-/- mice develop liver fibrosis
    Ewa Wandzioch
    Umeå Center for Molecular Medicine, Umea University, 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 101:16549-54. 2004
    ..Because the LIM homeobox gene Lhx2 is expressed in HSCs and liver development in Lhx2(-/-) mice is disrupted, we analyzed liver development in Lhx2(-/-..
  44. ncbi Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation
    S L Pfaff
    Howard Hughes Medical Institute, Department of Biochemistry and Molecule Biophysics, Columbia University, New York, New York 10032, USA
    Cell 84:309-20. 1996
    ..These results show that ISL1 is required for the generation of motor neurons and suggest that motor neuron generation is required for the subsequent differentiation of certain interneurons...
  45. ncbi The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS
    J H Millonig
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021 6399, USA
    Nature 403:764-9. 2000
    ..Lmx1a is expressed in the roof plate along the neuraxis during development of the CNS. Thus, Lmx1a is required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae...
  46. ncbi Boc is a receptor for sonic hedgehog in the guidance of commissural axons
    Ami Okada
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Nature 444:369-73. 2006
    ..Taken together, these data suggest that Boc is essential as a receptor for Shh in commissural axon guidance...
  47. doi BMP type I receptor complexes have distinct activities mediating cell fate and axon guidance decisions
    Ken Yamauchi
    Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Development 135:1119-28. 2008
    ..Taken together, these results indicate that the diverse activities of BMP morphogens can be accounted for by the differential use of distinct components of the canonical BMPR complex...
  48. doi A molecular program for contralateral trajectory: Rig-1 control by LIM homeodomain transcription factors
    Sara I Wilson
    Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA
    Neuron 59:413-24. 2008
    ..We show that two closely related LIM homeodomain proteins, Lhx2 and Lhx9, are expressed by a set of commissural relay neurons (dI1c neurons) and are required for the dI1c axon ..
  49. doi Differential expression of LIM-homeodomain factors in Cajal-Retzius cells of primates, rodents, and birds
    Antonio Abellan
    Laboratory of Brain Development and Evolution, Department of Experimental Medicine, Faculty of Medicine, University of Lleida, Institute of Biomedical Research of Lleida, 25008 Lleida, Spain
    Cereb Cortex 20:1788-98. 2010
    ..We have investigated the expression of the LIM-hd members Lhx1/Lhx2/Lhx5/Lhx6/Lhx9 in the reelin-expressing cells, the pallium, and the regions of origin of CR cells including the ..
  50. doi The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors
    Paula Marcos-Mondejar
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 32:4372-85. 2012
    ..Here, we demonstrate that the Lhx2 transcription factor is dynamically regulated in distinct pools of thalamic neurons during the development of ..
  51. doi LIM-homeodomain transcription factor, Lhx2, is involved in transcriptional control of brain-specific promoter/exon 1f of the mouse aromatase gene
    S Honda
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Neuroendocrinol 24:1367-74. 2012
    ..b>Lhx2, a LIM-homeodomain protein, was identified as one of the aro-B binding proteins...
  52. pmc Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis
    Itamar Harel
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 109:18839-44. 2012
    ..We identified Lhx2 as a previously undescribed player during cardiac and pharyngeal muscle development...
  53. pmc Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina
    Revathi Balasubramanian
    Flaum Eye Institute and Department of Ophthalmology, University of Rochester Medical Center, Rochester, NY 14642, USA Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, NY 14642, USA
    Gene Expr Patterns 14:1-8. 2014
    ..Here we report a detailed expression study of LIM-HD transcription factors LHX9 and LHX2, LHX3 and LHX4, and LHX6 in the developing and mature mouse retina using immunohistochemistry and in situ ..
  54. doi Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS
    Augusto Escalante
    Instituto de Neurociencias de Alicante Consejo Superior de Investigaciones Científicas Universidad Miguel Hernández, CSIC UMH, Campus San Juan, Av Ramon y Cajal s n, Alicante 03550, Spain
    Neuron 80:1392-406. 2013
    ..Together with previous reports, our data reveal a critical role for Zic2 as a determinant of axon midline avoidance in the CNS across species and pathways. ..
  55. doi LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling
    Aleksandar Kuzmanov
    Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland
    Mol Oncol 8:401-16. 2014
    ..Gene expression profiling has uncovered the transcription factor LIM homeobox gene 2 (Lhx2) with up-regulated expression during TGFβ-induced EMT in normal and cancerous breast epithelial cells...
  56. pmc Agenesis of the Corpus Callosum Due to Defective Glial Wedge Formation in Lhx2 Mutant Mice
    Gregory A Chinn
    Department of Developmental and Cell Biology, School of Biological Sciences, University of California Irvine, Irvine, CA, USA Department of Pathology and Laboratory Medicine, School of Medicine, University of California Irvine, Irvine, CA, USA
    Cereb Cortex 25:2707-18. 2015
    ..GW defects have been associated with agenesis of the corpus callosum (ACC). Here we show that conditional Lhx2 inactivation in cortical radial glia using Emx1-Cre or Nestin-Cre drivers results in ACC...
  57. pmc Lhx2 regulates bone remodeling in mice by modulating RANKL signaling in osteoclasts
    J H Kim
    1 Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Republic of Korea 2 Department of Pharmacology, Chonnam National University Medical School, Gwangju, Republic of Korea 3 Center for Creative Biomedical Scientists at Chonnam National University, Chonnam National University Medical School, Gwangju, Republic of Korea
    Cell Death Differ 21:1613-21. 2014
    The LIM homeobox 2 (Lhx2) transcription factor Lhx2 has a variety of functions, including neural induction, morphogenesis, and hematopoiesis. Here we show the involvement of Lhx2 in osteoclast differentiation...
  58. pmc The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation
    Juan Salvatierra
    Department of Neuroscience
    J Neurosci 34:16809-20. 2014
    ..We observe that LIM (Lin-11, Isl-1, Mec-3)-homeodomain gene Lhx2 is selectively expressed in hypothalamic progenitor cells and tanycytes...
  59. pmc Genetic chimeras reveal the autonomy requirements for Vsx2 in embryonic retinal progenitor cells
    Crystal L Sigulinsky
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, 65 Mario Capecchi Drive, Salt Lake City, UT, 84132, USA
    Neural Dev 10:12. 2015
    ..To define the autonomy requirements for Vsx2 in the regulation of RPC properties, we generated chimeric mouse embryos comprised of wild-type and Vsx2-deficient cells...
  60. pmc Transcription Factor CTIP2 Maintains Hair Follicle Stem Cell Pool and Contributes to Altered Expression of LHX2 and NFATC1
    Shreya Bhattacharya
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA
    J Invest Dermatol 135:2593-602. 2015
    ..CTIP2 appears to serve as a transcriptional organizer that integrates input from multiple signaling cues during HF morphogenesis and hair cycling...
  61. pmc A lifespan analysis of intraneocortical connections and gene expression in the mouse I
    Catherine A Dye
    Department of Psychology and Interdepartmental Neuroscience Program, University of California Riverside, 900 University Avenue, Riverside, CA 92521, USA
    Cereb Cortex 21:1311-30. 2011
    ..In this analysis, we utilize novel methods to correlate the boundaries of gene expression with INCs and developing areal boundaries, in order to better understand the nature of gene-areal relationships during development...
  62. pmc Basal progenitor cells in the embryonic mouse thalamus - their molecular characterization and the role of neurogenins and Pax6
    Lynn Wang
    Department of Neuroscience, Developmental Biology Center and Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Neural Dev 6:35. 2011
    ..These 'basal' progenitor cells form the subventricular zone and are responsible for generating the majority of neocortical neurons. However, not much has been studied on similar types of progenitor cells in other brain regions...
  63. pmc BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord
    Qian Ding
    Flaum Eye Institute and Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:1566-71. 2012
    ..These aberrations are preceded by ectopic dI1ipsi expression of the defining dI1contra TF, LHX2, and down-regulation of the dI1ipsi-enriched TF, BARHL1...
  64. doi Lhx2-dependent specification of olfactory sensory neurons is required for successful integration of olfactory, vomeronasal, and GnRH neurons
    Anna Berghard
    Department of Molecular Biology, Byggn 6L, Umea University, SE90187 Umeå, Sweden
    FASEB J 26:3464-72. 2012
    Inactivation of the LIM-homeodomain 2 gene (Lhx2) results in a severe defect in specification of olfactory sensory neurons (OSNs)...
  65. pmc Transcriptional analyses of two mouse models of spina bifida
    Robert M Cabrera
    Department of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX 78723, USA
    Birth Defects Res A Clin Mol Teratol 94:782-9. 2012
    ..Spina bifida is one of the most common of all human structural birth defects. Despite considerable effort over several decades, the causes and mechanisms underlying this malformation remain poorly characterized...
  66. doi Histone modification-mediated Lhx2 gene expression
    Key Sun Park
    Department of Biochemistry, Chungnam National University, Daejeon 305 764, Republic of Korea
    Biochem Biophys Res Commun 427:718-24. 2012
    b>Lhx2, a member of LIM homeobox transcription factors, plays a key role in central nervous system (CNS) and embryonic tissue development. However, molecular mechanism of Lhx2 gene regulation remains largely unknown...
  67. pmc Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes
    Mallika Chatterjee
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030 6403, USA
    Development 139:4633-43. 2012
    ..Robo expression by regulating LIM-domain transcription factors through three different mechanisms: Gbx2 and Lhx2 compete for binding to the Lmo3 promoter and exert opposing effects on its transcription; repressing Lmo3 by Gbx2 ..
  68. doi Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation
    Khalil Kass Youssef
    IRIBHM, Universite Libre de Bruxelles ULB, 808 Route de Lennik, 1070 Brussels, Belgium
    Nat Cell Biol 14:1282-94. 2012
    ..Deletion of β-catenin in adult SmoM2-expressing cells prevents EHFP reprogramming and tumour initiation. Finally, human basal cell carcinomas also express genes of the Wnt signalling and EHFP signatures...
  69. ncbi Progenitors of dorsal commissural interneurons are defined by MATH1 expression
    A W Helms
    Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Development 125:919-28. 1998
    ..Taken together, we demonstrate MATH1 expression in a differentiating population of neuronal precursors in the dorsal neural tube that appear to give rise specifically to dorsal commissural interneurons...
  70. ncbi RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex
    I Bach
    Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648, USA
    Nat Genet 22:394-9. 1999
    ..encoding Rlim, results in phenotypes similar to those observed after inhibition of the LIM homeodomain factor LHX2, which is required for the formation of distal structures along the proximodistal axis, or by overexpression of ..
  71. ncbi Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
    H Sasaki
    Laboratory of Developmental Biology, Institute for Molecular and Cellular Biology, Osaka University, Suita, Osaka 565 0871, Japan
    Development 126:3915-24. 1999
    ....
  72. ncbi Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
    S Arber
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Neuron 23:659-74. 1999
    ..These findings show that HB9 has an essential function in consolidating the identity of postmitotic MNs...
  73. ncbi Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification
    K J Lee
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Centre for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Nature 403:734-40. 2000
    ..These results reveal that the roof plate is essential for specifying multiple classes of neurons in the mammalian central nervous system...
  74. ncbi Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene
    J T Eggenschwiler
    Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Dev Biol 227:648-60. 2000
    ..The data indicate that opb(+) could act as either a novel component of a dorsalizing pathway or a novel intracellular negative regulator of the Shh signal transduction pathway...
  75. ncbi Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord
    R Scardigli
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, B P 163, 67404 Illkirch Cedex, C U, de Strasbourg, France
    Neuron 31:203-17. 2001
    ..Thus, neuronal differentiation involves crossregulatory interactions between a bHLH-driven program of neurogenesis and genetic pathways specifying progenitor and neuronal identity in the spinal cord...
  76. ncbi Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons
    K Gowan
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 31:219-32. 2001
    ..loss- and gain-of-function experiments, expression of Math1 or Ngn1 in dorsal progenitor cells determines whether LH2A/B- or dorsal Lim1/2-expressing interneurons will develop...
  77. ncbi Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord
    Michael K Gross
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 34:535-49. 2002
    ..Lbx1, therefore, plays a critical role in the development of sensory pathways in the spinal cord that relay pain and touch...
  78. ncbi Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex
    Koji Shinozaki
    Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Development 129:3479-92. 2002
    ....
  79. ncbi BMP signaling is required locally to pattern the dorsal telencephalic midline
    Jean M Hebert
    Department of Biological Sciences, Stanford University, 385 Serra Mall, CA 94305, USA
    Neuron 35:1029-41. 2002
    ..Our data fail to support a more global, concentration-dependent role in specifying telencephalic cell fates...
  80. ncbi Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding
    Kathie M Bishop
    Molecular Neurobiology Lab, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 457:345-60. 2003
    ..The more severe phenotypes in Emx double mutants suggest that Emx1 and Emx2 cooperate to regulate multiple features of cortical development...
  81. ncbi Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4
    Perry J Blackshear
    Office of Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Development 130:4539-52. 2003
    ..These findings may be relevant to human congenital hydrocephalus, a birth defect that affects approximately 0.6 per 1000 newborns...
  82. ncbi Tlx controls proliferation and patterning of lateral telencephalic progenitor domains
    Jan M Stenman
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Neurosci 23:10568-76. 2003
    ..Our results show that, although Gsh2 and Tlx have additive effects on striatal development, they differentially regulate the establishment of ventral pallial identity...
  83. ncbi The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate
    Teresa H Chae
    Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center and Department of Neurology and Program in Neuroscience, Harvard Medical School, HIM 816, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
    Nat Genet 36:264-70. 2004
    ..Apical localization of the SNARE Vamp7 is also disrupted. Thus, alpha Snap is essential for apical protein localization and cell fate determination in neuroepithelial cells...
  84. ncbi Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes
    Leping Cheng
    Dana Farber Cancer Institute, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Neurosci 8:1510-5. 2005
    ..These genetic studies suggest that Lbx1 expression defines a basal GABAergic differentiation state, and Tlx3 acts to antagonize Lbx1 to promote glutamatergic differentiation...
  85. ncbi Conserved regulatory elements establish the dynamic expression of Rpx/HesxI in early vertebrate development
    Shen Ju Chou
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Biol 292:533-45. 2006
    ..Furthermore, we have found that a conserved enhancer in the 3' regulatory sequences of Rpx is not only required, but is also sufficient for the expression of Rpx transgenes in the developing Rathke's pouch...
  86. ncbi The roof plate regulates cerebellar cell-type specification and proliferation
    Victor V Chizhikov
    Department of Human Genetics, University of Chicago, 920 E 58th Street, CLSC 319 Chicago, IL 60637, USA
    Development 133:2793-804. 2006
    ..Thus, in addition to the isthmus, the roof plate represents an important signaling center controlling multiple aspects of cerebellar patterning...
  87. pmc Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3
    Vassiliki Fotaki
    Genes and Development Group, Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:9282-92. 2006
    ..We propose that Gli3 is indispensable for formation of an intact telencephalic-diencephalic boundary and for preventing the abnormal positioning of diencephalic cells in the dorsal telencephalon...
  88. ncbi Six1 is essential for early neurogenesis in the development of olfactory epithelium
    Keiko Ikeda
    Division of Biology, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi 329 0498, Japan
    Dev Biol 311:53-68. 2007
    ..Our study indicates that Six1 plays critical roles in early neurogenesis by regulating Ngn1, NeuroD, Hes1, and Hes5...
  89. pmc Navigating neocortical neurogenesis and neuronal specification: a positional information system encoded by neurogenetic gradients
    Bernhard Suter
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 27:10777-84. 2007
    ..double-transgenic mice, overexpressing the cell cycle inhibitor p27(Kip1), we show that a gradient of expression of Lhx2 (inferred from its mRNA levels), a LIM homeodomain transcription factor, together with a gradient in duration of ..
  90. ncbi The localization of label-retaining cells in mouse nails
    Motonobu Nakamura
    J Invest Dermatol 128:728-30. 2008
  91. doi Specific glial populations regulate hippocampal morphogenesis
    Guy Barry
    The University of Queensland, Queensland Brain Institute, and School of Biomedical Sciences, Brisbane, 4067, Australia
    J Neurosci 28:12328-40. 2008
    ..These data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis...
  92. doi The role of Sonic hedgehog of neural origin in thalamic differentiation in the mouse
    Nora Emöke Szabó
    Department of Genes and Behavior, Max Planck Institute of Biophysical Chemistry, D 37077 Gottingen, Germany
    J Neurosci 29:2453-66. 2009
    ..In this way, the individual thalamic nuclei show differential dependence on Shh, Gbx2, or both for their differentiation. Additionally, Gbx2 is required for the survival of thalamic neurons...
  93. pmc The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice
    Martine Manuel
    Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 137:487-97. 2010
    ..These findings indicate that, in addition to regulating the production of ventralising signals, Foxg1 acts cell-autonomously in the telencephalon to ensure that cells develop the competence to adopt ventral identities...
  94. pmc Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    Fabrizio Thorel
    Department of Cell Physiology and Metabolism, University of Geneva Faculty of Medicine, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Nature 464:1149-54. 2010
    ..Such inter-endocrine spontaneous adult cell conversion could be harnessed towards methods of producing beta-cells for diabetes therapies, either in differentiation settings in vitro or in induced regeneration...
  95. doi Expression of major guidance receptors is differentially regulated in spinal commissural neurons transfated by mammalian Barh genes
    Daisuke Kawauchi
    Department of Developmental Biology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Dev Biol 344:1026-34. 2010
    ..Misexpression of Lhx2, which has been recently shown to be involved in Rig1 expression, activated Rig1 but not Nrp2, and was less ..
  96. pmc Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube
    Alisa S W Shum
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Dev Dyn 239:3192-203. 2010
    ..Taken together, these results support that the lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube...
  97. doi Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development
    Keiko Ikeda
    Division of Biology, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Int J Dev Biol 54:1453-64. 2010
    ....
  98. pmc Disrupted dorsal neural tube BMP signaling in the cilia mutant Arl13b hnn stems from abnormal Shh signaling
    Vanessa L Horner
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Biol 355:43-54. 2011
    ..We demonstrate that Arl13b is required non-autonomously for BMP signaling and Wnt ligand expression, indicating that the abnormal Shh signaling environment in Arl13b(hnn) embryos indirectly causes dorsal defects...
  99. ncbi Differential expression of LIM-homeodomain genes in the embryonic murine brain
    K Matsumoto
    Department of Structural Cellular Biology, Nara Institute of Science and Technology NAIST, Japan
    Neurosci Lett 211:147-50. 1996
    ..These mRNAs showed mutually exclusive expression patterns suggesting that these factors may be involved in region-specific differentiation in the developing brain...
  100. ncbi Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
    J Ericson
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 90:169-80. 1997
    ..2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain...

Research Grants2

  1. Development of Sensory maps in the Mammalian neocortex
    Yasushi Nakagawa; Fiscal Year: 2010
    ..abstract_text> ..
  2. INVESTIGATING THE ROLE OF CDO IN BRAIN DEVELOPMENT
    Ami Okada; Fiscal Year: 2004
    ..These experiments should also contribute to the overall understanding of the signals that are important in the assembly of the nervous system. ..