Lyve1

Summary

Gene Symbol: Lyve1
Description: lymphatic vessel endothelial hyaluronan receptor 1
Alias: 1200012G08Rik, Crsbp-1, Lyve-1, Xlkd1, lymphatic vessel endothelial hyaluronic acid receptor 1, cell surface retention sequence binding protein-1, extra cellular link domain-containing 1, extracellular link domain-containing protein 1, lymphatic vessel endothelial HA receptor-1, lymphatic vessel endothelial HA recptor-1
Species: mouse

Top Publications

  1. ncbi Inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1
    Louise A Johnson
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Biol Chem 282:33671-80. 2007
  2. doi A mechanism of sialylation functionally silences the hyaluronan receptor LYVE-1 in lymphatic endothelium
    Thomas D Nightingale
    Medical Research Council, Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Biol Chem 284:3935-45. 2009
  3. pmc LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
    S Banerji
    University of Oxford, Molecular Immunology Group, Nuffield Department of Medicine, John Radcliff Hospital, Headington, Oxford OX3 9DU, United Kingdom
    J Cell Biol 144:789-801. 1999
  4. ncbi Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium
    R Prevo
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Biol Chem 276:19420-30. 2001
  5. ncbi LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis
    C Mouta Carreira
    Steele Laboratory for Tumor Biology, Department of Radiation Oncology Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Res 61:8079-84. 2001
  6. pmc An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
    Jeffrey T Wigle
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 21:1505-13. 2002
  7. pmc Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk
    Farhad Abtahian
    Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 299:247-51. 2003
  8. pmc T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema
    Vivien Schacht
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    EMBO J 22:3546-56. 2003
  9. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
  10. pmc PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
    Taija Makinen
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    Genes Dev 19:397-410. 2005

Research Grants

  1. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
  2. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
  3. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
  4. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010

Scientific Experts

  • Stephanie J Munger
  • Kerstin Buttler
  • Tom Arnold
  • Stephane Germain
  • D Warburton
  • Jörg Wilting
  • Hiroshi Shimoda
  • Katsue Suzuki-Inoue
  • Ellen Berggreen
  • Masanori Hirashima
  • S L Dagenais
  • Hiroko Iwasaki
  • John D Kanady
  • Rui Cheng Ji
  • Adriana C Gittenberger-de Groot
  • Gabriela D'Amico
  • Kari Alitalo
  • Guillermo Oliver
  • R Sathish Srinivasan
  • Tatiana V Petrova
  • Naoyuki Miura
  • Taija Makinen
  • Zhiying Zou
  • Mathias Francois
  • Frederic Larrieu-Lahargue
  • Mark L Kahn
  • Paula Haiko
  • David G Jackson
  • Young Kwon Hong
  • Tuomas Tammela
  • Ralf H Adams
  • Mark F Vondenhoff
  • Peter Koopman
  • Michael Detmar
  • Nicholas W Gale
  • Natasha L Harvey
  • Friedemann Kiefer
  • Lara Planas-Paz
  • Yuichi Oike
  • Chiu Yu Chen
  • Christopher J Turner
  • Tohru Morisada
  • Ying Yang
  • Cécile Bénézech
  • Mei Chen
  • Dean Y Li
  • Taeko Ichise
  • Hirotake Ichise
  • Reina E Mebius
  • Brett Hosking
  • Dontscho Kerjaschki
  • Nobuaki Yoshida
  • Kaori Suzuki
  • Hidenori Nonaka
  • Camilla Norrmen
  • Min Min Lu
  • Seppo Yla-Herttuala
  • Johanna Liebl
  • Gou Young Koh
  • Kentaro Kajiya
  • Yan Agalarov
  • Marika J Karkkainen
  • Takashi Majima
  • Qiu Guo
  • Markus Moser
  • MinMin Lu
  • Bingruo Wu
  • Li Chin Yao
  • Inés Martínez-Corral
  • Shintaro Nakao
  • Adrian M Jubb
  • A Flaht
  • Brenda A Finney
  • Takahiro Hara
  • Amélie Sabine
  • Momina Mirza
  • Eckhard Lammert
  • Hyun Wook Lee
  • Katherine E Wardrop
  • Peter Baluk
  • Alan Yan
  • Wei Hsien Hou
  • Reinhard Fassler
  • Zoltán Kellermayer
  • Frank L Bos
  • Donald M McDonald
  • Nikolai Dicke
  • Marie Jeansson
  • Judy Mak
  • Patricia Mericko

Detail Information

Publications114 found, 100 shown here

  1. ncbi Inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1
    Louise A Johnson
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Biol Chem 282:33671-80. 2007
    ..These findings suggest that LYVE-1 can function independently of hyaluronan and have implications for the use of LYVE-1 as a histological marker for lymphangiogenesis in human pathology...
  2. doi A mechanism of sialylation functionally silences the hyaluronan receptor LYVE-1 in lymphatic endothelium
    Thomas D Nightingale
    Medical Research Council, Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Biol Chem 284:3935-45. 2009
    ..These results reveal unexpected complexity in the regulation of LYVE-1 function and raise the possibility that this receptor, like CD44, may become active after appropriate unmasking in vivo...
  3. pmc LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
    S Banerji
    University of Oxford, Molecular Immunology Group, Nuffield Department of Medicine, John Radcliff Hospital, Headington, Oxford OX3 9DU, United Kingdom
    J Cell Biol 144:789-801. 1999
    ..Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves...
  4. ncbi Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium
    R Prevo
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Biol Chem 276:19420-30. 2001
    ..Together these results suggest a role for LYVE-1 in the transport of HA from tissue to lymph and imply that further novel hyaluronan receptors must exist that can compensate for the loss of CD44 function...
  5. ncbi LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis
    C Mouta Carreira
    Steele Laboratory for Tumor Biology, Department of Radiation Oncology Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Res 61:8079-84. 2001
    ..Finally, the presence of LYVE-1 in liver sinusoidal endothelia suggests that LYVE-1 has functions beyond the lymph vascular system...
  6. pmc An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
    Jeffrey T Wigle
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 21:1505-13. 2002
    ..On the basis of our findings, we propose that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype...
  7. pmc Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk
    Farhad Abtahian
    Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 299:247-51. 2003
    ..These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals...
  8. pmc T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema
    Vivien Schacht
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    EMBO J 22:3546-56. 2003
    ..These data identify T1alpha/podoplanin as a novel critical player that regulates different key aspects of lymphatic vasculature formation...
  9. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
    ..Our results indicate that VEGF-C is the paracrine factor essential for lymphangiogenesis, and show that both Vegfc alleles are required for normal lymphatic development...
  10. pmc PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
    Taija Makinen
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    Genes Dev 19:397-410. 2005
    ..Our studies define ephrinB2 as an essential regulator of lymphatic development and indicate that interactions with PDZ domain effectors are required to mediate its functions...
  11. pmc Hepatocyte growth factor promotes lymphatic vessel formation and function
    Kentaro Kajiya
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    EMBO J 24:2885-95. 2005
    ..These results identify HGF as a novel, potent lymphangiogenesis factor, and also indicate that HGF-R might serve as a new target for inhibiting pathological lymphangiogenesis...
  12. ncbi Lymphatic development in mouse small intestine
    Kyung Eun Kim
    National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Korea
    Dev Dyn 236:2020-5. 2007
    ..Together, our study reveals the temporal and spatial windows of intestinal lymphatic development during embryonic development in mouse...
  13. doi Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos
    Masanori Hirashima
    The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Dev Biol 316:149-59. 2008
    ..Here we report novel lymphatic vascular phenotypes in Aspp1(-/-) mice; subcutaneous edema detected only during embryogenesis, delayed lymphatic vessel formation, and mispatterned collecting lymphatic vessels...
  14. pmc Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice
    Michael Dellinger
    Department of Molecular and Cellular Biology, The University of Arizona, Tucson, AZ, USA
    Dev Biol 319:309-20. 2008
    ..Taken together, this work pinpoints a specific lymphatic defect of Ang2(-/-) mice and further defines the sequential steps in lymphatic vessel remodeling...
  15. doi Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels
    Emma J Gordon
    Division of Haematology, The Hanson Institute, Adelaide, South Australia, Australia
    Dev Dyn 237:1901-9. 2008
    ..Our data are also the first demonstration, to our knowledge, that the mouse yolk sac is devoid of lymphatic vessels...
  16. doi Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 Haartmaninkatu 8, 00014 Helsinki, Finland
    Nature 454:656-60. 2008
    ..Our results implicate VEGFR-3 as a regulator of vascular network formation. Targeting VEGFR-3 may provide additional efficacy for anti-angiogenic therapies, especially towards vessels that are resistant to VEGF or VEGFR-2 inhibitors...
  17. pmc Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice
    Jianxin Fu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Clin Invest 118:3725-37. 2008
    ..Our studies therefore demonstrate that EC O-glycans control the separation of blood and lymphatic vessels during embryonic and postnatal development, in part by regulating podoplanin expression...
  18. doi Sox18 induces development of the lymphatic vasculature in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 456:643-7. 2008
    ..Our findings demonstrate a critical role for Sox18 in developmental lymphangiogenesis, and suggest new avenues to investigate for therapeutic management of human lymphangiopathies...
  19. pmc LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen
    Mark F Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    J Immunol 182:5439-45. 2009
    ..Furthermore, the same signals may regulate lymphangiogenesis to the lymph node through induction of VEGF-C...
  20. pmc FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1
    Camilla Norrmen
    Molecular Cancer Biology Program, Biomedicum Helsinki, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    J Cell Biol 185:439-57. 2009
    ..As damage to collecting vessels is a major cause of lymphatic dysfunction in humans, our results suggest that FOXC2 and NFATc1 are potential targets for therapeutic intervention...
  21. pmc Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis
    Eleni Bazigou
    Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Dev Cell 17:175-86. 2009
    ..Our findings reveal an important role for integrin-alpha9 signaling during lymphatic valve morphogenesis and implicate it as a candidate gene for primary lymphedema caused by valve defects...
  22. pmc Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
    Trung H M Pham
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 207:17-27. 2010
    ..Our data provide evidence that lymphatic endothelial cells are an in vivo source of S1P required for lymphocyte egress from LNs and Peyer's patches, and suggest a role for S1P in lymphatic vessel maturation...
  23. pmc Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3
    Yunling Xu
    Institut National de la Sante et de la Recherche Medicale, Unité 833, 75005 Paris, France
    J Cell Biol 188:115-30. 2010
    ..Thus, interaction between Nrp2 and VEGFR3 mediates proper lymphatic vessel sprouting in response to VEGF-C...
  24. doi Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation
    Pavel Uhrin
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Blood 115:3997-4005. 2010
    ..Therefore, interaction of endothelial podoplanin of the developing lymph sac with circulating platelets from the cardinal vein is critical for separating the lymphatic from the blood vascular system...
  25. doi H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice
    Taeko Ichise
    Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Development 137:1003-13. 2010
    ..Our findings demonstrate a cooperative function of the three Ras proteins in normal development, and also provide a novel aspect of VEGFR3 signalling modulated by Ras in lymphangiogenesis...
  26. doi Regulation of developmental lymphangiogenesis by Syk(+) leukocytes
    Ruben Böhmer
    Department of Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D 48149 Munster, Germany
    Dev Cell 18:437-49. 2010
    ..This mechanism does not involve circulating endothelial progenitor cells and demonstrates the potential of hematopoietic cells to control developmental lymphangiogenesis...
  27. pmc Netrin-4 induces lymphangiogenesis in vivo
    Frederic Larrieu-Lahargue
    Program in Molecular Medicine, Department of Medicine, University of Utah, Salt Lake City, UT, USA
    Blood 115:5418-26. 2010
    ..Together, these data provide evidence that Netrin-4 is a lymphangiogenic factor contributing to tumor dissemination and represents a potential target to inhibit metastasis formation...
  28. doi VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis
    Luqing Zhang
    Laboratory of Vascular and Cancer Biology, MOE Key Laboratory for Model Animal and Disease Study, Model Animal Research Institute, Nanjing University, 12 Xue Fu Road, Nanjing 210061, China
    Cell Res 20:1319-31. 2010
    ..These findings indicate that signaling mediated via VEGFR-3 activation by its cognate ligands (VEGF-C/-D) is not required for angiogenesis, and that VEGFR-3 may play a role in this process by modulating VEGFR-2-mediated signals...
  29. doi CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo
    Frank L Bos
    Hubrecht Institute KNAW, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Circ Res 109:486-91. 2011
    ..Insight into the molecular role of CCBE1 is completely lacking, and mouse models for the disease do not exist...
  30. pmc Netrin-4 activates endothelial integrin {alpha}6{beta}1
    Frederic Larrieu-Lahargue
    University of Utah, Eccles Institute of Human Genetics, Salt Lake City, UT 84112, USA
    Circ Res 109:770-4. 2011
    ..Netrin family members were shown to signal through a range of receptors, including integrins (such as α3β1, α6β1, and α6β4) in nonendothelial cells...
  31. pmc Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves
    R Sathish Srinivasan
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 25:2187-97. 2011
    ..This is the first report describing the molecular mechanism controlling lymphovenous communication...
  32. pmc Discontinuous LYVE-1 expression in corneal limbal lymphatics: dual function as microvalves and immunological hot spots
    Shintaro Nakao
    Center for Excellence in Functional and Molecular Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    FASEB J 26:808-17. 2012
    ..LYVE-1(-) lymphatic endothelium could serve as microvalves, supporting unidirectional flow, as well as immunological hot spots that facilitate reentry of stromal macropahges...
  33. pmc Mechanoinduction of lymph vessel expansion
    Lara Planas-Paz
    Institute of Metabolic Physiology, Heinrich Heine University, Dusseldorf, Germany
    EMBO J 31:788-804. 2012
    ..Thus, we propose a new and physiologically relevant mode of VEGFR3 activation, which is based on mechanotransduction and is essential for normal development and fluid homeostasis in a mammalian embryo...
  34. doi Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Dev Biol 364:89-98. 2012
    ..Our data support a new model for lymphatic vascular patterning and morphogenesis, as a basis for identifying the molecular cues governing these processes...
  35. doi Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation
    Amélie Sabine
    Division of Experimental Oncology, Multidisciplinary Oncology Center, University Hospital of Lausanne, Switzerland
    Dev Cell 22:430-45. 2012
    ..Our results also provide molecular insights into the role of endothelial cell identity in the regulation of vascular mechanotransduction...
  36. pmc Blood flow reprograms lymphatic vessels to blood vessels
    Chiu Yu Chen
    Department of Medicine and Division of Cardiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 122:2006-17. 2012
    ..These findings reveal that blood flow can convert lymphatic vessels to blood vessels, demonstrating that hemodynamic forces may reprogram endothelial and vessel identity in cardiovascular diseases associated with abnormal flow...
  37. pmc Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos
    Ying Yang
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 120:2340-8. 2012
    ..Analyzing this process in Prox1-null embryos revealed that Prox1 activity is necessary for LEC progenitors to exit the CV...
  38. pmc The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis
    Zhiying Zou
    Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 121:3228-36. 2013
    ..Our findings reveal that CCBE1 plays an essential role in regulating the fetal liver erythropoietic environment and suggest that EBI formation is regulated differently in the fetal liver and bone marrow...
  39. ncbi Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
    Tatiana V Petrova
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
    Nat Med 10:974-81. 2004
    ..Our results indicate that an abnormal interaction between the lymphatic endothelial cells and pericytes, as well as valve defects, underlie the pathogenesis of LD...
  40. ncbi Mesenchymal cells with leukocyte and lymphendothelial characteristics in murine embryos
    Kerstin Buttler
    Children s Hospital, Pediatrics I, University of Goettingen, Goettingen, Germany
    Dev Dyn 235:1554-62. 2006
    ..Such stem cells may also be present in the human and may be the cell of origin in post-transplantation Kaposi sarcoma...
  41. pmc Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1
    Nicholas W Gale
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    Mol Cell Biol 27:595-604. 2007
    ..These results indicate that LYVE-1 is not obligatory for normal lymphatic development and function and suggest either the existence of compensatory receptors or a role more specific than that previously envisaged...
  42. ncbi Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain
    Shin ichiro Takayanagi
    Laboratory of Stem Cell Therapy, Center for Experimental Medicine, University of Tokyo, Japan
    Blood 107:4317-25. 2006
    ....
  43. pmc CRSBP-1/LYVE-l-null mice exhibit identifiable morphological and functional alterations of lymphatic capillary vessels
    S S Huang
    Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    FEBS Lett 580:6259-68. 2006
    ..The CRSBP-1 ligands PDGF-BB and HA enhance interstitial-lymphatic flow in wild-type mice but not in CRSBP-1-null animals...
  44. doi Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice
    Brett Hosking
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Development 136:2385-91. 2009
    ..Our studies identify Sox7 and Sox17 as modifiers of the Sox18 mutant phenotype, and reveal their mechanism of action as a novel mode of strain-specific compensatory upregulation...
  45. doi LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis
    Hayakazu Sumida
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Blood 116:5060-70. 2010
    ..Considering the critical role of autotaxin (an enzyme involved in LPA production) and Gα(13) in vascular development, we suggest that LPA(4) provides a link between these 2 molecules...
  46. pmc Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice
    Momina Mirza
    Department of Women s and Children s Health, Karolinska Institute and University Hospital, Stockholm, Sweden
    PLoS ONE 7:e37523. 2012
    ..The results show that CAR plays an essential role in development of the lymphatic vasculature in the mouse embryo by promoting appropriate formation of lymphatic endothelial cell-cell junctions...
  47. doi Cellular phenotypes and spatio-temporal patterns of lymphatic vessel development in embryonic mouse hearts
    A Flaht
    Department of Pathomorphology, Medical University of Warsaw, Warsaw, Poland
    Dev Dyn 241:1473-86. 2012
    ..We aimed to establish the stage when lymphatic vessels appear in the developing mouse heart, the location of the first lymphatics, and to define cellular phenotypes of growing lymphatics...
  48. pmc Mouse lymphatic endothelial cell targeted probes: anti-LYVE-1 antibody-based magnetic nanoparticles
    Qiu Guo
    Department of Radiology, The First Hospital of China Medical University, Shenyang, Liaoning, PR China
    Int J Nanomedicine 8:2273-84. 2013
    ....
  49. pmc An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo
    Takashi Majima
    Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan
    PLoS ONE 8:e68134. 2013
    ..These results indicate that afadin has different effects on blood and lymphatic endothelial cells by controlling the levels of RhoA activation, which may critically regulate the lymphangiogenesis of mouse embryos. ..
  50. pmc Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation
    Christopher J Turner
    Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Biol 392:381-92. 2014
    ....
  51. pmc Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain
    Thomas D Arnold
    Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 177 77 Stockholm, Sweden
    Development 141:4489-99. 2014
    ..Our data therefore suggest that abnormal vascular sprouting and patterning, not BBB dysfunction, underlie developmental cerebral hemorrhage...
  52. doi Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2
    Johanna Liebl
    Department of Pharmacy, Pharmaceutical Biology, Ludwig Maximilians University, 81377 Munich, Germany
    Nat Commun 6:7274. 2015
    ..Collectively, our findings show that Cdk5-Foxc2 interaction represents a critical regulator of lymphatic vessel development and the transcriptional network underlying lymphatic vascular remodeling. ..
  53. ncbi Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation
    Tohru Morisada
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan
    Blood 105:4649-56. 2005
    ..On the basis of these observations, we propose that Ang signaling regulates lymphatic vessel formation through Tie2...
  54. ncbi Angiogenic role of LYVE-1-positive macrophages in adipose tissue
    Chung Hyun Cho
    National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Circ Res 100:e47-57. 2007
    ....
  55. pmc Proinflammatory signals and the loss of lymphatic vessel hyaluronan receptor-1 (LYVE-1) in the early pathogenesis of laminin alpha2-deficient skeletal muscle
    Katherine E Wardrop
    Boston Biomedical Research Institute, Watertown, Massachusetts 02472, USA
    J Histochem Cytochem 59:167-79. 2011
    ..Together, the data show that inflammatory pathways are activated in the earliest stages of Lama2-deficient disease progression and could play a role in early muscle degeneration...
  56. pmc Angiopoietin-1 is essential in mouse vasculature during development and in response to injury
    Marie Jeansson
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    J Clin Invest 121:2278-89. 2011
    ..These findings redefine our understanding of the biological roles of angiopoietin-1: it is dispensable in quiescent vessels but has a powerful ability to modulate the vascular response after injury...
  57. pmc Absence of Nkx2-3 homeodomain transcription factor induces the formation of LYVE-1-positive endothelial cysts without lymphatic commitment in the spleen
    Zoltán Kellermayer
    Department of Immunology and Biotechnology, University of Pecs, Faculty of Medicine, Hungary
    J Histochem Cytochem 59:690-700. 2011
    ..Thus the splenic vascular defects in Nkx2-3 deficiency include the generation of LYVE-1(+) cysts, comprised of endothelial cells without being committed along the LEC lineage...
  58. doi Peripheral lymphangiogenesis in mice depends on ectodermal connexin-26 (Gjb2)
    Nikolai Dicke
    Institute of Genetics, Division of Molecular Genetics, University of Bonn, 53117 Bonn, Germany
    J Cell Sci 124:2806-15. 2011
    ..We conclude that appropriate development of dermal lymphatic vessels in mice is dependent on the expression of Cx26 in the ectoderm...
  59. doi Neuropilin-1 expression in cancer and development
    Adrian M Jubb
    Department of Pathology, Genentech Inc, South San Francisco, CA 94080, USA
    J Pathol 226:50-60. 2012
    ..These observations confirm NRP1 as a valid anti-angiogenic target in malignancy, and as a potential direct anti-tumour target in a subset of cancers. The data also confirm a role for NRP1 in physiological, VEGF-mediated angiogenesis...
  60. pmc CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development
    Brenda A Finney
    Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    Blood 119:1747-56. 2012
    ....
  61. pmc In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis
    Inés Martínez-Corral
    Biotechnology Programme, Spanish National Cancer Research Centre, CNIO, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 109:6223-8. 2012
    ..This is the first reporter mouse model for luminescence imaging of lymphangiogenesis. It should provide an important tool for studying the involvement of lymphangiogenesis in pathological processes...
  62. pmc Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation
    Li Chin Yao
    Department of Anatomy, Cardiovascular Research Institute, and the Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Am J Pathol 180:2561-75. 2012
    ..These findings demonstrate the plasticity of intercellular junctions in lymphatics during development and inflammation and show that button formation can be promoted by glucocorticoid receptor signaling in lymphatic endothelial cells...
  63. doi Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice
    Takahiro Hara
    Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    J Immunol 189:1577-84. 2012
    ..Overall, IL-7-GFP knock-in mice serve as a unique and powerful tool to examine the identity and distribution of IL-7-expressing cells in vivo...
  64. pmc Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling
    Bingruo Wu
    Departments of Genetics, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 151:1083-96. 2012
    ..This information may help develop better cell therapies for coronary artery disease...
  65. ncbi Cell surface retention sequence binding protein-1 interacts with the v-sis gene product and platelet-derived growth factor beta-type receptor in simian sarcoma virus-transformed cells
    C Boensch
    Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 274:10582-9. 1999
    ..v-sis gene product) complex is transported to the cell surface where it presents the v-sis gene product to unoccupied PDGF beta-type receptors during internalization/recycling...
  66. ncbi Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
    Natasha L Harvey
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Nat Genet 37:1072-81. 2005
    ..Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease...
  67. ncbi Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly
    Shane S Foo
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Cell 124:161-73. 2006
    ..Our results indicate that the role of ephrin-B2 and EphB receptors in these processes involves Crk-p130(CAS) signaling and suggest that ephrin-B2 has some cell-cell-contact-independent functions...
  68. ncbi Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice
    Toshiyasu Matsui
    Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    J Cell Sci 119:3513-26. 2006
    ..Therefore, our findings indicate that Sox17 and Sox18, and possibly all three SoxF genes, are cooperatively involved in mammalian vascular development...
  69. pmc Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development
    Xianghua Zhou
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Goteborg University, SE 413 45 Goteborg, Sweden
    Proc Natl Acad Sci U S A 104:3919-24. 2007
    ..These mice died or had to be euthanized before 4 weeks of age. Thus, the phenotypes of Flnb-deficient mice closely resemble those of human skeletal disorders with mutations in FLNB...
  70. ncbi The proepicardium delivers hemangioblasts but not lymphangioblasts to the developing heart
    Jörg Wilting
    Children s Hospital, Pediatrics I, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Dev Biol 305:451-9. 2007
    ..5, indicating a contribution of immigrating lymphangioblasts to the cardiac lymphatic system. Our studies show that coronary blood and lymph vessels are derived from different sources, but grow in close association with each other...
  71. pmc Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling
    Koji Taniguchi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Fukuoka, Japan
    Mol Cell Biol 27:4541-50. 2007
    ..These data suggest that Spreds play an important role in lymphatic vessel development by negatively regulating VEGF-C/VEGFR-3 signaling...
  72. pmc Emilin1 deficiency causes structural and functional defects of lymphatic vasculature
    Carla Danussi
    Division of Experimental Oncology 2, Department of Molecular Oncology and Translational Research, CRO IRCCS, Aviano, Pordenone, Italy
    Mol Cell Biol 28:4026-39. 2008
    ..The phenotype displayed by Emilin1(-/-) mice is the first abnormal lymphatic phenotype associated with the deficiency of an ECM protein and identifies EMILIN1 as a novel local regulator of lymphangiogenesis...
  73. pmc Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics
    Kerstin Buttler
    Centre of Anatomy, Department of Anatomy and Cell Biology, University Medicine Goettingen, Goettingen, Germany
    BMC Dev Biol 8:43. 2008
    ..Here, we have characterized the mesoderm of murine embryos with LEC markers Prox1, Lyve-1 and LA102 in combination with macrophage markers CD11b and F4/80...
  74. pmc HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification
    Carley A E Shaut
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Genet 4:e1000073. 2008
    ....
  75. doi p75 Neurotrophin receptor is a marker for precursors of stellate cells and portal fibroblasts in mouse fetal liver
    Kaori Suzuki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Gastroenterology 135:270-281.e3. 2008
    ..HSCs and PFs play pivotal roles in liver regeneration and fibrosis. However, the roles of mesenchymal cells in fetal liver remain poorly understood. In this study, we aimed to characterize mesenchymal cells in mouse fetal liver...
  76. pmc Growth hormone promotes lymphangiogenesis
    Nadja Erika Banziger-Tobler
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang Pauli Str 10, HCI H303, CH 8093 Zurich, Switzerland
    Am J Pathol 173:586-97. 2008
    ..These results identify growth hormone as a novel lymphangiogenic factor...
  77. doi Immunohistochemical demonstration of Angiopoietin-2 in lymphatic vascular development
    Hiroshi Shimoda
    Department of Human Anatomy, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama machi, Yufu, Oita, 879 5593, Japan
    Histochem Cell Biol 131:231-8. 2009
    ....
  78. pmc Lymph sacs are not required for the initiation of lymph node formation
    Mark F Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Development 136:29-34. 2009
    ..5 Prox1 conditional mutant embryos, which have defective lymph sacs. However, subsequent clustering of hematopoietic cells within these developing lymph nodes is less efficient...
  79. pmc Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway
    Benjamin Kleaveland
    Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 421 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Med 15:169-76. 2009
    ..This study identifies HEG1-CCM protein signaling as a crucial regulator of heart and vessel formation and integrity...
  80. pmc Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice
    Mai X Luong
    Department of Radiation Oncology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Cell Physiol 219:430-7. 2009
    ..These data suggest that LYVE-1 and CD44 are not required for the formation or function of lymphatics, but do not rule out a role for LYVE-1 in inflammation...
  81. doi Characterization of the dental lymphatic system and identification of cells immunopositive to specific lymphatic markers
    Ellen Berggreen
    Department of Biomedicine, Faculty of Medicine and Odontology, University of Bergen, Bergen, Norway
    Eur J Oral Sci 117:34-42. 2009
    ..In inflamed pulp these cells were not observed. Macrophages are suggested to contribute directly to the formation of lymphatic vessels after pulp exposure...
  82. doi A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships
    Ferdinando Pucci
    Angiogenesis and Tumor Targeting Research Unit, San Raffaele Institute, Olgettina 58, Milan, Italy
    Blood 114:901-14. 2009
    ....
  83. doi Myc regulates embryonic vascular permeability and remodeling
    Eniko Kokai
    Institute of Physiological Chemistry, Ulm University, Ulm, Germany
    Circ Res 104:1151-9. 2009
    ..Thus, the net outcome of an excess of vascular endothelial growth factor-A and angiopoietin-2 in the face of an elevated cellular turnover appears to be a defect in vascular integrity...
  84. doi Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report
    Gabriela D'Amico
    Molecular Cancer Biology Laboratory, Biomedicum Helsinki, Department of Pathology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 30:207-9. 2010
    ..We tested the hypothesis that the swelling observed in Tie1 mutant embryos is associated with lymphatic vascular defects...
  85. pmc Expression of lymphatic markers during avian and mouse cardiogenesis
    Ganga Karunamuni
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
    Anat Rec (Hoboken) 293:259-70. 2010
    ....
  86. doi Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis
    Laura Carramolino
    Departamento de Biología del Desarrollo Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain
    Circ Res 106:1197-201. 2010
    ..However, the basis for these defects has remained unknown because the mutations characterized affect more than one blood lineage...
  87. doi Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase
    Rogier M Reijmers
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 184:3656-64. 2010
    ....
  88. pmc Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling
    Cara C Bertozzi
    Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Blood 116:661-70. 2010
    ..These studies identify a nonhemostatic pathway in which platelet CLEC-2 receptors bind lymphatic endothelial PDPN and activate SLP-76 signaling to regulate embryonic vascular development...
  89. pmc Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development
    Fu Jung Lin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 120:1694-707. 2010
    ..Thus, COUP-TFII is a critical factor that controls lymphangiogenesis in embryonic development and tumorigenesis in adults...
  90. pmc Tbx1 regulates Vegfr3 and is required for lymphatic vessel development
    Li Chen
    Program of Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 189:417-24. 2010
    ..Our findings reveal a novel pathway for the development of the lymphatic vessel network...
  91. doi Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver
    Hiroko Iwasaki
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan
    Blood 116:544-53. 2010
    ..In conclusion, EPCR(+) HSCs resided in the perisinusoidal niche in mouse FL...
  92. pmc Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    J Biol Chem 285:24494-507. 2010
    ..We propose that CLEC-2 could be an ideal novel target protein for an anti-platelet drug, which inhibits pathological thrombus formation but not physiological hemostasis...
  93. pmc Novel discovery of LYVE-1 expression in the hyaloid vascular system
    Hui Zhang
    Center for Eye Disease and Development, School of Optometry, University of California, Berkeley, CA 94720, USA
    Invest Ophthalmol Vis Sci 51:6157-61. 2010
    ..To date, there is no report on its expression in the HVS. This study was conducted to investigate whether LYVE-1 is expressed in the HVS and how it is associated with the vascular structure and macrophage phenotype...
  94. doi Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidney
    Hyun Wook Lee
    Department of Anatomy and MRC for Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, 505, Banpo dong, Seocho Ku, Seoul, 137 701, Korea
    Cell Tissue Res 343:429-44. 2011
    ..Thus, lymphatic vessels of the kidney might originate by extension of extra-renal lymphatics through an active branching process possibly associated with F4/80(+)/CD11b(-)/LYVE-1(+) macrophages/dendritic cells...
  95. pmc Mechanisms of lymphatic regeneration after tissue transfer
    Alan Yan
    the Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e17201. 2011
    ..The purpose of these studies was to investigate the mechanisms that regulate lymphatic regeneration after tissue transfer...
  96. pmc CRSBP-1/LYVE-1 ligands disrupt lymphatic intercellular adhesion by inducing tyrosine phosphorylation and internalization of VE-cadherin
    Wei Hsien Hou
    Departments of Biochemistry and Molecular Biology, St Louis University School of Medicine, Doisy Research Center, 1100 S Grand Boulevard, St Louis, MO 63104, USA
    J Cell Sci 124:1231-44. 2011
    ..These results disclose a novel mechanism involved in the opening of lymphatic intercellular junctions...
  97. pmc Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis
    Jay W Shin
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mol Biol Cell 17:576-84. 2006
    ..Together, these results indicate that FGFR-3 is an initial target of Prox1 during the lymphatic cell fate specification and that FGF signaling may play an important role in lymphatic vessel development...
  98. ncbi The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development
    Seungwoon Seo
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Dev Biol 294:458-70. 2006
    ..Taken together, our results demonstrate that Foxc transcription factors are novel regulators of arterial cell specification upstream of Notch signaling and lymphatic sprouting during embryonic development...
  99. ncbi Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors
    Hidenori Nonaka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Dev Dyn 236:2258-67. 2007
    ..Our results provide new insight into the development of tissue-specific ECs and phenotypic criteria to distinguish HSECs from other types of ECs, including LECs...
  100. pmc Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression
    Carrie J Shawber
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 117:3369-82. 2007
    ..These results demonstrate that Notch1 and VEGFR-3 interact genetically, that Notch directly induces VEGFR-3 in blood endothelial cells to regulate vascular development, and that Notch may function in tumor lymphangiogenesis...

Research Grants4

  1. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  2. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  3. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  4. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..