Mecom

Summary

Gene Symbol: Mecom
Description: MDS1 and EVI1 complex locus
Alias: D630039M04Rik, Evi-1, Evi1, Jbo, Mds, Mds1, Mds1-Evi1, Prdm3, Znfpr1b1, MDS1 and EVI1 complex locus protein EVI1, MDS1 and EVI1 complex locus protein MDS1, ecotropic viral integration site 1, ecotropic virus integration site 1 protein, myelodysplasia syndrome 1 homolog, myelodysplasia syndrome 1 protein homolog
Species: mouse

Top Publications

  1. ncbi Induction of two alternatively spliced evi-1 proto-oncogene transcripts by cAMP in kidney cells
    C Bartholomew
    Beatson Institute for Cancer Research, Cancer Research Campaign Beatson Laboratories, Bearsden, Glasgow
    Oncogene 9:939-42. 1994
  2. ncbi Retroviral integration in murine myeloid tumors to identify Evi-1, a novel locus encoding a zinc-finger protein
    N G Copeland
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Adv Cancer Res 54:141-57. 1990
  3. pmc Tissue restricted expression and chromosomal localization of the YB-1 gene encoding a 42 kD nuclear CCAAT binding protein
    D D Spitkovsky
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG
    Nucleic Acids Res 20:797-803. 1992
  4. doi Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells
    Susumu Goyama
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, The University of Tokyo Hospital, Tokyo 113 8655, Japan
    Cell Stem Cell 3:207-20. 2008
  5. ncbi The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG
    T Funabiki
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Oncogene 9:1575-81. 1994
  6. pmc Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors
    Emilie A Bard-Chapeau
    Institute of Molecular and Cell Biology, Singapore 138673
    Proc Natl Acad Sci U S A 109:2168-73. 2012
  7. pmc Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity
    Keisuke Kataoka
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Exp Med 208:2403-16. 2011
  8. ncbi The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development
    P R Hoyt
    University of Tennessee Graduate School of Biomedical Sciences, Biology Division, Oak Ridge National Laboratory, TN 37831 8080, USA
    Mech Dev 65:55-70. 1997
  9. doi Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins
    Akihide Yoshimi
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Blood 117:3617-28. 2011
  10. doi Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells
    Shunya Arai
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Blood 117:6304-14. 2011

Scientific Experts

  • Hisamaru Hirai
  • J Norrander
  • Vitalyi Senyuk
  • Rotraud Wieser
  • Jerome Dickstein
  • Yi Zhang
  • Michael T Cheeseman
  • Mineo Kurokawa
  • Susumu Goyama
  • Akihide Yoshimi
  • Shunya Arai
  • Tomohiko Sato
  • Munetake Shimabe
  • Dominik Spensberger
  • Hiroshi Kobayashi
  • Naoko Watanabe-Okochi
  • Yoichi Imai
  • Masahiro Nakagawa
  • Ruud Delwel
  • Archibald S Perkins
  • Ali Azar
  • S Fukuda
  • Victoria C Garside
  • Roger McGilvray
  • Bogdan Yatsula
  • T Sato
  • C Bartholomew
  • Xiyun Deng
  • Sami Kamel Boualia
  • Yang Li
  • Toshio Kitamura
  • Takako Tsuruta
  • Inês Pinheiro
  • Jeff Ishibashi
  • Eric M J Bindels
  • Chiyo Mizuochi
  • Emilie A Bard-Chapeau
  • Mariam Malik
  • Yaned Gaitan
  • Maxime Bouchard
  • Keiki Kumano
  • A Yoshimi
  • M Kurokawa
  • S Goyama
  • Keisuke Kataoka
  • Sami K Boualia
  • Akiko Nagamachi
  • P Roy
  • Toshio Suda
  • Motoshi Ichikawa
  • M Shimabe
  • Yanna Cao
  • Tien C Ko
  • Neal G Copeland
  • Daisuke Sugiyama
  • Nancy A Jenkins
  • U Modlich
  • Yuanyuan Qiu
  • Leopoldo Laricchia-Robbio
  • G Nucifora
  • Chris Bartholomew
  • Jérôme Cartry
  • Hadi Alzuherri
  • Nicholas Parkinson
  • K Maki
  • Giuseppina Nucifora
  • Yang Du
  • Hiromi Yuasa
  • Tamara Alliston
  • Yian Wang
  • N G Copeland
  • Helen Brown
  • Denis Headon
  • Chiara Piccinelli
  • Yiqing Chi
  • N A Jenkins
  • Keiyo Takubo
  • P Singh
  • M Abe
  • Daiki Karigane
  • Marco A Marra
  • J Hoggatt
  • Taku Sato
  • Ayako Nakamura-Ishizu
  • P Hu
  • Toshiaki Ohteki
  • S Yamaguchi
  • Ryan Vander Werff
  • J M Speth
  • Yongjun Zhao

Detail Information

Publications83

  1. ncbi Induction of two alternatively spliced evi-1 proto-oncogene transcripts by cAMP in kidney cells
    C Bartholomew
    Beatson Institute for Cancer Research, Cancer Research Campaign Beatson Laboratories, Bearsden, Glasgow
    Oncogene 9:939-42. 1994
    ....
  2. ncbi Retroviral integration in murine myeloid tumors to identify Evi-1, a novel locus encoding a zinc-finger protein
    N G Copeland
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Adv Cancer Res 54:141-57. 1990
  3. pmc Tissue restricted expression and chromosomal localization of the YB-1 gene encoding a 42 kD nuclear CCAAT binding protein
    D D Spitkovsky
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG
    Nucleic Acids Res 20:797-803. 1992
    ..Finally, we have identified four YB-1 related loci in the mouse genome and have mapped these loci to four different mouse chromosomes by interspecific backcross analysis...
  4. doi Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells
    Susumu Goyama
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, The University of Tokyo Hospital, Tokyo 113 8655, Japan
    Cell Stem Cell 3:207-20. 2008
    ..Thus, Evi-1 is a common and critical regulator essential for proliferation of embryonic/adult HSCs and transformed leukemic cells...
  5. ncbi The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG
    T Funabiki
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Oncogene 9:1575-81. 1994
    ..Although Evi-1 contains potential transcriptional activation domains, it was not able to activate gene transcription from CAT constructs containing the consensus sequence...
  6. pmc Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors
    Emilie A Bard-Chapeau
    Institute of Molecular and Cell Biology, Singapore 138673
    Proc Natl Acad Sci U S A 109:2168-73. 2012
    b>Ecotropic viral integration site 1 (EVI1) is an oncogenic dual domain zinc finger transcription factor that plays an essential role in the regulation of hematopoietic stem cell renewal, and its overexpression in myeloid leukemia and ..
  7. pmc Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity
    Keisuke Kataoka
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Exp Med 208:2403-16. 2011
    b>Ecotropic viral integration site 1 (Evi1), a transcription factor of the SET/PR domain protein family, is essential for the maintenance of hematopoietic stem cells (HSCs) in mice and is overexpressed in several myeloid malignancies...
  8. ncbi The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development
    P R Hoyt
    University of Tennessee Graduate School of Biomedical Sciences, Biology Division, Oak Ridge National Laboratory, TN 37831 8080, USA
    Mech Dev 65:55-70. 1997
    The ecotropic viral integration site-1 (Evi1) locus was initially identified as a common site of retroviral integration in myeloid tumors of the AKXD-23 recombinant inbred mouse strain...
  9. doi Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins
    Akihide Yoshimi
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Blood 117:3617-28. 2011
    Evi1 (ecotropic viral integration site 1) is essential for proliferation of hematopoietic stem cells and implicated in the development of myeloid disorders...
  10. doi Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells
    Shunya Arai
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Blood 117:6304-14. 2011
    ..Our findings indicate that Evi-1 is one of the targets of MLL oncoproteins and is selectively activated in hematopoietic stem cell-derived MLL leukemic cells...
  11. pmc Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome
    Jerome Dickstein
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:9783-8. 2010
    By expressing EVI1 in murine bone marrow (BM), we previously described a myelodysplastic syndrome (MDS) model characterized by pancytopenia, dysmegakaryopoiesis, dyserythropoiesis, and BM failure...
  12. doi Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells
    M Shimabe
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Oncogene 28:4364-74. 2009
    ..These results indicate that Pbx1 is a target gene of Evi-1 involved in Evi-1-mediated leukemogenesis...
  13. pmc Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells
    Yang Du
    Mouse Cancer Genetics Program, National Cancer Institute, Center for Cancer Research, Frederick, MD 21702, USA
    Blood 106:3932-9. 2005
    ..More than half of the lines have MSCV insertions at Evi1 or Prdm16. These loci encode transcription factor homologs and are validated human myeloid leukemia genes...
  14. ncbi Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins
    S Palmer
    Glasgow Caledonian University, School of Biological and Biomedical Sciences, City Campus, Cowcaddens Rd, Glasgow, G4 OBA, Scotland
    J Biol Chem 276:25834-40. 2001
    Ectopic production of the EVI1 transcriptional repressor zinc finger protein is seen in 4--6% of human acute myeloid leukemias...
  15. ncbi Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles
    S Chakraborty
    Department of Pathology and The Cancer Center, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Biol Chem 276:44936-43. 2001
    b>EVI1 is a very complex protein with two domains of zinc fingers and is inappropriately expressed in many types of human myeloid leukemias...
  16. ncbi EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity
    Yiqing Chi
    Department of Pathology and The Cancer Center, University of Illinois, Chicago, Illinois 60607, USA
    J Biol Chem 278:49806-11. 2003
    b>EVI1 is a complex protein required for embryogenesis and inappropriately expressed in many types of human myeloid leukemia...
  17. pmc Significant increase of self-renewal in hematopoietic cells after forced expression of EVI1
    Leopoldo Laricchia-Robbio
    Department of Medicine, University of Illinois at Chicago M C 737, 909 South Wolcott Avenue, Chicago, IL 60612, USA
    Blood Cells Mol Dis 40:141-7. 2008
    EVI1 was first identified as a preferential integration site of ecotropic retroviruses in the MDS1/EVI1 genomic locus leading to myeloid tumors in susceptible mice...
  18. pmc Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media
    Nicholas Parkinson
    Mammalian Gentics Unit, Medical Research Council, Harwell, United Kingdom
    PLoS Genet 2:e149. 2006
    ..identified the causal mutation, a missense change in the C-terminal zinc finger region of the transcription factor Evi1. This protein is expressed in middle ear basal epithelial cells, fibroblasts, and neutrophil leukocytes at ..
  19. pmc Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression
    Hiromi Yuasa
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan
    EMBO J 24:1976-87. 2005
    The ecotropic viral integration site-1 (Evi1) is an oncogenic transcription factor in murine and human myeloid leukemia...
  20. ncbi Identification of binding sites of EVI1 in mammalian cells
    Bogdan Yatsula
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510 8023, USA
    J Biol Chem 280:30712-22. 2005
    The leukemia-associated protein EVI1 possesses seven zinc fingers within an N-terminal domain (amino acids 1-250) that binds to GACAAGATA...
  21. ncbi Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts
    K Morishita
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Oncogene 5:963-71. 1990
    ..The possible basis for the unique expression of the Evi-1 gene by HEC-1 cells could not be determined by karyotype or Southern blot analysis...
  22. doi The shortest isoform of C/EBPβ, liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model
    Naoko Watanabe-Okochi
    Department of Hematology and Oncology, Graduate School of Medicine, Universityof Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Blood 121:4142-55. 2013
    b>Ecotropic viral integration site 1 (Evi1) is one of the master regulators in the development of acute myeloid leukemia (AML) and myelodysplastic syndrome...
  23. ncbi Alternative splicing of the Evi-1 zinc finger gene generates mRNAs which differ by the number of zinc finger motifs
    D Bordereaux
    Laboratoire Immunologie et Oncologie des Maladies Rétrovirales, INSERM U152, Hopital Cochin, Paris, France
    Oncogene 5:925-7. 1990
    ..This was confirmed by Northern blot analysis and S1 mapping experiments. Therefore, the Evi-1 gene codes potentially for at least two proteins of 1042 and 718 amino acids differing in the numbers of their zinc-finger motifs...
  24. ncbi Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain
    T Tanaka
    Department of Molecular Biology, Jichi Medical School, Tochigi, Japan
    J Biol Chem 269:24020-6. 1994
    ..We constructed deletion mutants of Evi-1 and investigated the functions of these domains. It was shown that the second zinc finger domain is essential for the activation of AP-1 and transactivation of the c-fos promoter...
  25. ncbi Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors
    M L Mucenski
    NCI Frederick Cancer Research Facility, BRI Basic Research Program, Maryland 21701
    Oncogene Res 2:219-33. 1988
    ..These results suggest that Evi-1 represents a new locus involved in myeloid disease...
  26. ncbi Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines
    K Morishita
    NCI Frederick Cancer Research Facility, Molecular Mechanisms of Carcinogenesis Laboratory, Maryland 21701
    Cell 54:831-40. 1988
    ..This represents the first demonstration of the retroviral activation of a gene encoding a zinc finger protein and the first implication for a member of this gene family in the transformation of hematopoietic cells...
  27. pmc Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors
    M L Mucenski
    Mammalian Genetics Laboratory, National Cancer Institute, Frederick, Maryland 21701
    Mol Cell Biol 8:301-8. 1988
    ..We designated this locus Evi-1 (ecotropic viral integration site 1)...
  28. ncbi The EVI-1 gene--its role in pathogenesis of human leukemias
    J Jółkowska
    Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60 479, Poznan, Poland
    Leuk Res 24:553-8. 2000
    ..Occurrence of a few EVI-1 fusion transcripts was shown. The role of this fusion proteins is still unclear. Mouse and human sequences of the gene show a high degree of homology; 91% in nucleotide sequence and 94% in amino acid sequence...
  29. pmc Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene
    T Matsugi
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Mol Cell Biol 10:1259-64. 1990
    ..These antisera primarily detected a 145-kilodalton nuclear protein that bound double-stranded DNA. Binding was inhibited by chelating agents and partially restored by zinc ions...
  30. ncbi Patterns of Evi-1 expression in embryonic and adult tissues suggest that Evi-1 plays an important regulatory role in mouse development
    A S Perkins
    NCI Frederick Cancer Research and Development Center, ABL Basic Research Program, MD 21702
    Development 111:479-87. 1991
    ..Expression in the limb occurs at the highest levels from 9.5 to 12.5 days, is present in both hind and forelimbs, is absent at the apical ectodermal ridge, and does not appear to establish a gradient.(ABSTRACT TRUNCATED AT 250 WORDS)..
  31. ncbi Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1
    W S Moseley
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 5:899-905. 1989
    ..These studies provide a model for examination of specific evolutionary events...
  32. ncbi The transcription factor Evi-1
    H Hirai
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Int J Biochem Cell Biol 31:1367-71. 1999
    ..In the aspect of potential therapeutic approaches, some pharmaceutical drugs or antisense oligonucleotides that repress Evi-1 expression would be useful for the treatment of Evi-1-induced neoplastic tumors...
  33. ncbi Retroviral insertions in the CB-1/Fim-3 common site of integration activate expression of the Evi-1 gene
    C Bartholomew
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38101
    Oncogene 4:529-34. 1989
    ..These results demonstrate that the CB-1/Fim-3 and Evi-1 loci constitute a large genomic region in which viral integrations activate the transcription of a new potential myeloid transforming gene...
  34. pmc Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1
    S Fukuda
    Department of Pediatrics, Shimane University School of Medicine, Izumo, Japan
    Leukemia 29:433-40. 2015
    ..These data demonstrate that Survivin partially regulates HSC function by modulating the Evi-1 transcription factor and its downstream targets and identify new genetic pathways in HSCs regulated by Survivin. ..
  35. doi Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING
    Hiroshi Kobayashi
    Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo 162 8655, Japan Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Tokyo 160 8582, Japan Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Cell Rep 11:71-84. 2015
    ..Our results define machinery underlying the dynamic regulation of HSPCs and their niches during bacterial infection through c-di-GMP/STING signaling. ..
  36. doi SOX9 modulates the expression of key transcription factors required for heart valve development
    Victoria C Garside
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, Canada V5Z 1L3 Program in Cell and Developmental Biology, University of British Columbia, Vancouver, Canada V6T 1Z4
    Development 142:4340-50. 2015
    ..several transcription factors with previously identified roles in heart valve development, including Twist1, Sox4, Mecom and Pitx2...
  37. pmc Ectodysplasin signalling deficiency in mouse models of hypohidrotic ectodermal dysplasia leads to middle ear and nasal pathology
    Ali Azar
    Developmental Biology Division
    Hum Mol Genet 25:3564-3577. 2016
    ....
  38. ncbi Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1
    Tamara Alliston
    Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, California 94143 0512, USA
    J Biol Chem 280:24227-37. 2005
    ..In this way, Evi-1 acts as a general Smad corepressor to inhibit TGF-beta-, activin-, and BMP-inducible transcription...
  39. doi Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors
    Yuanyuan Qiu
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Biochemistry 47:3697-704. 2008
    ..GATA6 and Evi-1 are highly expressed early during cardiogenesis of ES cells, suggesting that they may regulate expression of the calreticulin gene during cardiac development...
  40. pmc Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia
    T Sato
    1 Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 2 Department of Transfusion Medicine, The University of Tokyo Hospital, Tokyo, Japan
    Oncogene 33:5028-38. 2014
    ..b>Ecotropic viral integration site 1 (EVI1), a key transcription factor in HSC regulation, is known to predict poor outcomes in myeloid ..
  41. doi The relationship between Evi-1 expression and mouse ovarian follicular development
    Yang Li
    Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, Ji Nan, China
    Acta Histochem 114:79-86. 2012
    ..Overall, the results indicate that Evi-1 is expressed in a stage-specific manner during ovarian follicular development and may be involved in early follicle development...
  42. pmc Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia
    Yi Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY and
    Blood 122:2888-92. 2013
    A subgroup of leukemogenic mixed-lineage leukemia (MLL) fusion proteins (MFPs) including MLL-AF9 activates the Mecom locus and exhibits extremely poor clinical prognosis...
  43. pmc An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation
    Jeff Ishibashi
    Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 32:2289-99. 2012
    ..We show here that the zinc finger protein Evi1 increases in preadipocytes at the onset of differentiation prior to increases in PPARγ levels...
  44. doi A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis
    Sami Kamel Boualia
    Goodman Cancer Research Centre and Department of Biochemistry, McGill University, 1160 Pine Ave W, Montreal, Quebec, Canada H3A 1A3
    Dev Biol 382:555-66. 2013
    ....
  45. pmc EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs
    Eric M J Bindels
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 119:5838-49. 2012
    The proto-oncogene EVI1 (ecotropic viral integration site-1), located on chromosome band 3q26, is aberrantly expressed in human acute myeloid leukemia (AML) with 3q26 rearrangements...
  46. pmc Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimulating factor
    K Morishita
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Mol Cell Biol 12:183-9. 1992
    ..These results support the hypothesis that the inappropriate expression of the Evi-1 gene in myeloid cells interferes with the ability of the cells to terminally differentiate...
  47. pmc Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer
    Xiyun Deng
    Department of Surgery, The University of Texas Health Science Center, Houston, TX 77026, USA
    Mol Carcinog 52:255-64. 2013
    ..We have also identified a novel Evi-1 transcript, Evi-1e, as the major Evi-1 transcript expressed in human CRCs...
  48. pmc Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation
    Mariam Malik
    Laboratory of Cancer Biology and Genetics and Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:6130-5. 2012
    ..In mice, genetically null for CLIC4, the number of phagocytosing macrophages stimulated by LPS is reduced. Thus, iNOS-induced nuclear CLIC4 is an essential part of the macrophage deactivation program...
  49. doi Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity
    Inês Pinheiro
    Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Stubeweg 51, 79108 Freiburg, Germany
    Cell 150:948-60. 2012
    ..We developed a biochemical assay and used in vivo analyses in mouse embryonic fibroblasts to identify Prdm3 and Prdm16 as redundant H3K9me1-specific KMTs that direct cytoplasmic H3K9me1 methylation...
  50. pmc Intra-aortic clusters undergo endothelial to hematopoietic phenotypic transition during early embryogenesis
    Chiyo Mizuochi
    Department of Hematopoietic Stem Cells, SSP Stem Cell Unit, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan
    PLoS ONE 7:e35763. 2012
    ..These results suggest that the transition from endothelial to hematopoietic phenotype of IACs occurs after 9.5 dpc...
  51. pmc Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2
    Sami K Boualia
    Department of Biochemistry and Goodman Cancer Centre, McGill University, Montreal, Quebec, Canada
    PLoS ONE 6:e21529. 2011
    ..As both genes are located on human chromosome 10q, which is lost in a proportion of VUR patients, these findings may help understand VUR and CAKUT in humans...
  52. pmc The oncoprotein EVI1 and the DNA methyltransferase Dnmt3 co-operate in binding and de novo methylation of target DNA
    Vitalyi Senyuk
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e20793. 2011
    b>EVI1 has pleiotropic functions during murine embryogenesis and its targeted disruption leads to prenatal death by severely affecting the development of virtually all embryonic organs...
  53. pmc HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants
    Michael T Cheeseman
    MRC Mammalian Genetics Unit, MRC Harwell, Harwell, United Kingdom
    PLoS Genet 7:e1002336. 2011
    ..Our analysis of the Junbo and Jeff mutants highlights the role of hypoxia and HIF-mediated pathways, and we conclude that targeting molecules in HIF-VEGF signaling pathways has therapeutic potential in the treatment of chronic OM...
  54. ncbi Chromosomal localization of murine and human oligodendrocyte-specific protein genes
    J M Bronstein
    Department of Neurology, UCLA School of Medicine, Los Angeles, California, 90024, USA
    Genomics 34:255-7. 1996
    ..Fine mapping with fluorescence in situ hybridization placed the OSP gene at human chromosome 3q26.2-q26.3. To date, there are no known inherited neurological disorders that localize to these regions...
  55. ncbi Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias
    T Nakamura
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
    Nat Genet 12:149-53. 1996
    ..These studies provide the first genetic evidence that Pbx1-related genes cooperate with Hox genes in leukaemia formation and identify a number of new murine myeloid leukaemia genes...
  56. ncbi Molecular diversity of the SCG10/stathmin gene family in the mouse
    T Okazaki
    Division of Neurogerontology, Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles 90089
    Genomics 18:360-73. 1993
    ..These data are consistent with the idea that the neuron-specific SCG10 gene evolved by duplication and modification of the more broadly expressed stathmin/Lap18 gene...
  57. ncbi Genetic mapping of the gene encoding guanylate cyclase-A/atrial natriuretic factor receptor (Npra) to mouse chromosome 3
    K N Pandey
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, School of Medicine, Augusta 30912 2100
    Mamm Genome 5:520-2. 1994
  58. ncbi Four human chromosome 3q and four human chromosome 21 loci map onto sheep chromosome 1q
    T E Broad
    Gene Mapping Unit, AgResearch Grasslands Research Centre, Palmerston North, New Zealand
    Mamm Genome 6:202-5. 1995
    ..ceruloplasmin (CP), sucrase isomaltase (SI), glucose transporter 2 (GLUT2), and ectopic viral integration site 1 (EVI1)...
  59. pmc Structure of endogenous murine leukemia virus DNA in mouse genomes
    S K Chattopadhyay
    Proc Natl Acad Sci U S A 77:5774-8. 1980
    ..All inbred mouse strains tested also contained MuLV DNAs of genomic length whose restriction endonuclease digestion pattern was characteristic of xenotropic viruses...
  60. pmc Fim-1, Fim-2/c-fms, and Fim-3, three common integration sites of Friend murine leukemia virus in myeloblastic leukemias, map to mouse chromosomes 13, 18, and 3, respectively
    B Sola
    Institut National de la Santé et de la Recherche Médicale U152 Centre National de la Recherche Scientifique, UA628, Hopital Cochin, Paris, France
    J Virol 62:3973-8. 1988
    ..Fim-2 spans the 5' end of the c-fms gene, which encodes for the macrophage-colony-stimulating factor receptor. We located the c-fms gene on the D band of chromosome 18 by in situ hybridization...
  61. ncbi Localization of the murine macrophage colony-stimulating factor gene to chromosome 3 using interspecific backcross analysis
    A M Buchberg
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genomics 5:363-7. 1989
    ..The location of Csfm also identifies yet another mouse chromosome that shares synteny with human chromosome 5q, a region involved in several different types of myeloid disease...
  62. ncbi The murine M-CSF gene is localized on chromosome 3
    S Gisselbrecht
    Institut National de la Santé et de la Recherche Médicale U152, Hopital Cochin, Paris, France
    Blood 73:1742-5. 1989
  63. ncbi Zinc finger protein genes in the mouse genome
    A Ashworth
    Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    Mamm Genome 1:196-200. 1991
  64. ncbi Glucose transporter gene expression in early mouse embryos
    A Hogan
    Department of Medical Biochemistry, University of Calgary Health Sciences Center, Alberta, Canada
    Development 113:363-72. 1991
    ..Genetic mapping studies of glucose transporters in the mouse show that Glut-1 is located on chromosome 4, Glut-2 on chromosome 3, Glut-3 on chromosome 6, and Glut-4 on chromosome 11...
  65. ncbi Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site
    C Y Chen
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 148:2817-25. 1992
    ..The model predicts that the two enzymes have similar clefts that comprise the active site and permit zinc-dependent substrate interactions...
  66. doi A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a
    Dominik Spensberger
    Department of Hematology, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    FEBS Lett 582:2761-7. 2008
    The transcription factor ecotropic viral integration site 1 (Evi1) is associated with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) in patients due to chromosomal aberration of chromosome 3...
  67. ncbi Retinoic acid signalling is required for specification of pronephric cell fate
    Jérôme Cartry
    Laboratoire de Biologie du Developpement, équipe Signalisation et Morphogenèse, UMR CNRS 7622, Universite Paris VI, 9 quai Saint Bernard, 75005 Paris, France
    Dev Biol 299:35-51. 2006
    ..Raldh2 knockout mouse embryos fail to initiate the expression of early kidney-specific genes, suggesting that implication of RA signalling in the early steps of kidney formation is evolutionary conserved in vertebrates...
  68. ncbi Conservation and expression of a novel alternatively spliced Evi1 exon
    Hadi Alzuherri
    Glasgow Caledonian University, Department of Biological and Biomedical Sciences, City Campus Cowcaddens Road Glasgow, G4 OBA, United Kingdom
    Gene 384:154-62. 2006
    The Evi1 transcriptional repressor protein is expressed in a developmentally regulated manner, is essential for normal development, participates in regulating cell proliferation and differentiation of cells of haemopoietic and neuronal ..
  69. ncbi The oncogene and developmental regulator EVI1: expression, biochemical properties, and biological functions
    Rotraud Wieser
    Department of Medical Genetics, Medical University of Vienna, Währingerstr, 10, A 1090 Wien, Austria
    Gene 396:346-57. 2007
    The EVI1 gene codes for a zinc finger transcription factor with important roles both in normal development and in leukemogenesis...
  70. ncbi UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation
    Roger McGilvray
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, UK
    FEBS J 274:3960-71. 2007
    The EVI1 transcriptional repressor is critical to the normal development of a variety of tissues and participates in the progression of acute myeloid leukaemias...
  71. ncbi Erythroid defects and increased retrovirally-induced tumor formation in Evi1 transgenic mice
    D Louz
    Institute of Hematology, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands
    Leukemia 14:1876-84. 2000
    Aberrant expression of the Evi1 (ecotropic virus integration site 1) proto-oncogene has been associated with hematopoietic malignancies in both mice and man...
  72. doi Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16
    U Modlich
    Department of Experimental Hematology, Hannover Medical School, Hannover, Germany
    Leukemia 22:1519-28. 2008
    ..of six distinct clones harboring gamma-retroviral long terminal repeat (LTR) or SIN vector insertions in Evi1 or Prdm16, two functionally related genes...
  73. doi Myeloid transforming protein Evi1 interacts with methyl-CpG binding domain protein 3 and inhibits in vitro histone deacetylation by Mbd3/Mi-2/NuRD
    Dominik Spensberger
    Department of Hematology, Erasmus University Medical Center, Rotterdam 3015 GE, The Netherlands
    Biochemistry 47:6418-26. 2008
    The ecotropic viral integration site 1 ( Evi1) gene encodes a putative transcription regulator, which is aberrantly expressed in acute myeloid leukemias (AML) with chromosomal abnormalities involving the 3q26 locus...
  74. ncbi Development of megakaryoblastic leukaemia in Runx1-Evi1 knock-in chimaeric mouse
    K Maki
    Leukemia 20:1458-60. 2006
  75. ncbi Restriction landmark genomic scanning of mouse liver tumors for gene amplification: overexpression of cyclin A2
    R Haddad
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Biochem Biophys Res Commun 274:188-96. 2000
    ..Our results also indicate that our mouse model for liver tumorigenesis in mice accurately recapitulates events observed in human hepatocellular carcinoma...
  76. ncbi Comparative expression analysis of the antagonistic transcription factors EVI1 and MDS1-EVI1 in murine tissues and during in vitro hematopoietic differentiation
    K Wimmer
    Institut für Medizinische Biologie der Universität Wien, Währingerstrasse 10, Wien, A 1090, Austria
    Biochem Biophys Res Commun 252:691-6. 1998
    An alternative form of the transcription factor EVI1, MDS1-EVI1, which previously had been believed to exist only in the context of leukemic fusion mRNAs, has recently been shown to be expressed also in normal human tissues...
  77. ncbi Expression of ciliary tektins in brain and sensory development
    J Norrander
    Department of Cell Biology and Neuroanatomy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 18:8912-8. 1998
    ..The evolutionary conservation of tektins and their association with tubulin in cilia and centriole formation make them important and useful molecular targets for the study of neural development...
  78. doi A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model
    Akiko Nagamachi
    Department of Molecular Oncology, Research Institute of Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Dev Biol 345:226-36. 2010
    ..the roles of the IRES element in Runx1 function, we generated knock-in mice for either wild-type Runx1 or Runx1/Evi1, a Runx1 fusion protein identified in human leukemia...
  79. ncbi Chromosomal localization of acquired MMTV proviral integration sites in T-cell lymphomas
    L Rajan
    Department of Microbiology, University of Texas at Austin 78712, USA
    Mamm Genome 9:84-5. 1998
  80. pmc Cloning and expression analysis of murine phospholipase D1
    W C Colley
    Department of Pharmacological Sciences, Program in Genetics, State University of New York, Stony Brook, NY 11794 8651, USA
    Biochem J 326:745-53. 1997
    ..Thus the two PLDs probably carry out distinct roles in restricted subsets of cells rather than ubiquitous roles in all cells...
  81. ncbi Mouse annexin V chromosomal localization, cDNA sequence conservation, and molecular evolution
    M I Rodriguez-Garcia
    Department of Biochemistry and Molecular Biology, University of Oviedo, Spain
    Genomics 31:151-7. 1996
    ..Comparison of nine species of ANX5 led to an estimation of the unit evolutionary mutation rate at 1% aa replacements every 8 million years, comparable to other annexins...
  82. doi Enhanced sensitivity to hydrogen peroxide-induced apoptosis in Evi1 transformed Rat1 fibroblasts due to repression of carbonic anhydrase III
    P Roy
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, City Campus, Glasgow, UK
    FEBS J 277:441-52. 2010
    b>EVI1 is a nuclear zinc finger protein essential to normal development, which participates in acute myeloid leukaemia progression and transforms Rat1 fibroblasts...
  83. ncbi A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility
    Yian Wang
    Department of Surgery and the Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 64:1647-54. 2004
    ..Furthermore, this model can be used in determining genetic modifiers that contribute to susceptibility or resistance to lung SCC development...