Mir155

Summary

Gene Symbol: Mir155
Description: microRNA 155
Alias: Mirn155, mmu-mir-155
Species: mouse

Top Publications

  1. pmc 1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages
    Yunzi Chen
    Division of Biological Sciences, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Immunol 190:3687-95. 2013
  2. pmc Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis
    Manuel Koch
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin 10117, Germany
    Proc Natl Acad Sci U S A 109:E1153-62. 2012
  3. pmc MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, 330 Braun, 1200 E California Boulevard, Pasadena, CA 91125, USA
    Immunity 33:607-19. 2010
  4. doi Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1
    Pin Wang
    National Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai, China
    J Immunol 185:6226-33. 2010
  5. pmc Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease
    Shashi Bala
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 286:1436-44. 2011
  6. pmc miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1
    Changming Lu
    Pediatric Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Blood 117:4293-303. 2011
  7. pmc MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis
    Mariola Kurowska-Stolarska
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 108:11193-8. 2011
  8. pmc Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis
    Gopal Murugaiyan
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 187:2213-21. 2011
  9. doi MicroRNA-155 is essential for the T cell-mediated control of Helicobacter pylori infection and for the induction of chronic Gastritis and Colitis
    Mathias Oertli
    Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland
    J Immunol 187:3578-86. 2011
  10. doi TNFα-induced up-regulation of miR-155 inhibits adipogenesis by down-regulating early adipogenic transcription factors
    Sanhong Liu
    Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Biochem Biophys Res Commun 414:618-24. 2011

Scientific Experts

  • Rossana Trotta
  • Thomas Waldmann
  • Yongan Liu
  • Adrian Billeter
  • Yongwei Qin
  • Laura K Fonken
  • Fang Yu
  • Anne M Curtis
  • Simon Clare
  • Ana L Cardoso
  • Krisztina Juhász
  • K Basso
  • M Turner
  • Wayne Tam
  • Lei Luo
  • Elena Vigorito
  • Ryan M O'Connell
  • Stefan Costinean
  • Stephane Heymans
  • Mariola Kurowska-Stolarska
  • Aadel A Chaudhuri
  • David Baltimore
  • Klaus Rajewsky
  • To Ha Thai
  • Yuanyuan Wei
  • Ruozhen Hu
  • Maliheh Nazari-Jahantigh
  • Menno P J de Winther
  • Blanche Schroen
  • Maarten F Corsten
  • Thomas B Huffaker
  • Manuel Koch
  • June L Round
  • Ramiro Garzon
  • Carlo M Croce
  • Sakari Kauppinen
  • Sukhinder K Sandhu
  • Danilo Perrotti
  • Susanna Obad
  • Stefano Volinia
  • Dinesh S Rao
  • Sadaf Farsinejad
  • Sebastian Grundmann
  • Sophia Chen
  • Alexandre K Rouquette-Jazdanian
  • Robert B Lochhead
  • Steffen U Eisenhardt
  • Aida Karachi
  • Daniel Arango
  • Jinli Wang
  • Lin Wang
  • Limin Li
  • Roshni Rao
  • Thelma Escobar
  • Raj Kishore
  • Yunzi Chen
  • Leon N Schulte
  • Ching Yi Tsai
  • Chunliang Xu
  • Rong Wu
  • Stefan A Muljo
  • Ashley M Miller
  • Jan C Dudda
  • Evan F Lind
  • Erika Zonari
  • Sang Hoon Sin
  • Zhongliang Guo
  • Carolyn L Zawislak
  • Marah C Runtsch
  • Wouter Verhesen
  • Paolo Carai
  • Erin Bake
  • Andreas Schober
  • Kathrin Heyll
  • Christian Weber
  • Mark Hazebroek
  • Erwin Wijnands
  • Marjo M P C Donners
  • Parvathi Ranganathan
  • Liat Nadav Dagan
  • Imran A Babar
  • Derek S Gilchrist
  • Tingting Wu
  • Ramasamy Santhanam
  • Christine Dahlke
  • Zhong hua Wang
  • Rui Yao
  • Ranjeet Kumar
  • Juliane Lescher
  • Devram Sampat Ghorpade

Detail Information

Publications92

  1. pmc 1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages
    Yunzi Chen
    Division of Biological Sciences, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Immunol 190:3687-95. 2013
    ..Together, these data identify a novel regulatory mechanism for vitamin D to control innate immunity...
  2. pmc Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis
    Manuel Koch
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin 10117, Germany
    Proc Natl Acad Sci U S A 109:E1153-62. 2012
    ..pylori pathogenicity factor, the T4SS, in the up-regulation of miR-155 in BMMs. We propose the antiapoptotic effects of miR-155 could enhance macrophage resistance to apoptosis induced by DNA damage during H. pylori infection...
  3. pmc MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, 330 Braun, 1200 E California Boulevard, Pasadena, CA 91125, USA
    Immunity 33:607-19. 2010
    ..Consistent with a positive role for miR-155 in mediating inflammatory responses, Mir155(-/-) mice were highly resistant to experimental autoimmune encephalomyelitis (EAE)...
  4. doi Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1
    Pin Wang
    National Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai, China
    J Immunol 185:6226-33. 2010
    ..Therefore, we demonstrate that inducible miR-155 feedback positively regulates host antiviral innate immune response by promoting type I IFN signaling via targeting SOCS1...
  5. pmc Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease
    Shashi Bala
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 286:1436-44. 2011
    ..In conclusion, our novel data demonstrate that chronic alcohol consumption increases miR-155 in macrophages via NF-κB and the increased miR-155 contributes to alcohol-induced elevation in TNFα production via increased mRNA stability...
  6. pmc miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1
    Changming Lu
    Pediatric Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Blood 117:4293-303. 2011
    ..Thus, our study uncovered miRNA signatures during monocyte differentiation into DCs and the new regulatory role of miR-221 and miR-155 in DC apoptosis and IL-12p70 production...
  7. pmc MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis
    Mariola Kurowska-Stolarska
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 108:11193-8. 2011
    ..Our data therefore identify a role of miR-155 in clinical and experimental arthritis and suggest that miR-155 may be an intriguing therapeutic target...
  8. pmc Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis
    Gopal Murugaiyan
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 187:2213-21. 2011
    ..These findings demonstrate that Mir-155 confers susceptibility to EAE by affecting inflammatory T cell responses and identify Mir-155 as a new target for therapeutic intervention in multiple sclerosis...
  9. doi MicroRNA-155 is essential for the T cell-mediated control of Helicobacter pylori infection and for the induction of chronic Gastritis and Colitis
    Mathias Oertli
    Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland
    J Immunol 187:3578-86. 2011
    ..In conclusion, miR-155 expression is required for the Th17/Th1 differentiation that underlies immunity to H. pylori infection on the one hand and infection-associated immunopathology on the other...
  10. doi TNFα-induced up-regulation of miR-155 inhibits adipogenesis by down-regulating early adipogenic transcription factors
    Sanhong Liu
    Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Biochem Biophys Res Commun 414:618-24. 2011
    ..Taken together, these findings reveal a novel role for TNFα in the regulation of anti-adipogenic miRNAs...
  11. pmc miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production
    Ana L Cardoso
    Centre for Neuroscience and Cell Biology, University of Coimbra, Portugal
    Immunology 135:73-88. 2012
    ....
  12. pmc miR-155 regulates HGAL expression and increases lymphoma cell motility
    Liat Nadav Dagan
    Division of Hematology Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, FL 33136, USA
    Blood 119:513-20. 2012
    ..Furthermore, this effect may contribute to lymphoma cell dissemination and aggressiveness, characteristic of activated B cell-like diffuse large B-cell lymphoma typically expressing high levels of miR-155 and lacking HGAL expression...
  13. pmc miR-155 regulates IFN-γ production in natural killer cells
    Rossana Trotta
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Blood 119:3478-85. 2012
    ..These findings may have clinical relevance for targeting miR-155 in neoplastic disease...
  14. pmc MicroRNA-155 is required for Mycobacterium bovis BCG-mediated apoptosis of macrophages
    Devram Sampat Ghorpade
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
    Mol Cell Biol 32:2239-53. 2012
    ..Overall, M. bovis BCG-driven miR-155 dictates cell fate decisions of infected macrophages, strongly implicating a novel role for miR-155 in orchestrating cellular reprogramming during immune responses to mycobacterial infection...
  15. ncbi Regulation of the germinal center response by microRNA-155
    To Ha Thai
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Science 316:604-8. 2007
    ..miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo...
  16. pmc Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice
    Marjo M P C Donners
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 7:e35877. 2012
    microRNA-155 (miR155) is a central regulator of immune responses that is induced by inflammatory mediators...
  17. doi MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis
    Maarten F Corsten
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    Circ Res 111:415-25. 2012
    ..The involvement of microRNAs and their usefulness as therapeutic targets in this process are unknown...
  18. pmc MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages
    Maliheh Nazari-Jahantigh
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany
    J Clin Invest 122:4190-202. 2012
    ..Leukocyte-specific Mir155 deficiency reduced plaque size and number of lesional macrophages after partial carotid ligation in ..
  19. pmc Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing
    Leon N Schulte
    RNA Biology Group, Institute for Molecular Infection Biology, University of Wurzburg, Josef Schneider Strasse 2 D15, D 97080 Wurzburg, Germany
    Nucleic Acids Res 41:542-53. 2013
    ..We predict that dose-dependent responses to environmental stimuli may involve functional specialization of seemingly co-induced miRNAs in other cellular circuitries as well...
  20. pmc Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity
    Thomas B Huffaker
    Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
    Cell Rep 2:1697-709. 2012
    ..Our work reveals critical roles for miRNAs in the reciprocal regulation of CD4(+) and CD8(+) T cell-mediated antitumor immunity and demonstrates the dominant nature of miR-155 during its promotion of immune responses...
  21. pmc MicroRNA miR-155 affects antiviral effector and effector Memory CD8 T cell differentiation
    Ching Yi Tsai
    Microbiology and Immunology Department, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA
    J Virol 87:2348-51. 2013
    ..At the memory stage, miR-155-deficient CD8 T cells preferentially differentiated into central memory cells and were capable of mounting a potent secondary response...
  22. pmc Enhanced susceptibility to Citrobacter rodentium infection in microRNA-155-deficient mice
    Simon Clare
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    Infect Immun 81:723-32. 2013
    ..A similarly susceptible phenotype was observed in μMT mice reconstituted with miR-155-deficient B cells, indicating that miR-155 is required intrinsically for mediating protection against this predominantly luminal bacterial pathogen...
  23. doi Micro-RNA 155 is required for optimal CD8+ T cell responses to acute viral and intracellular bacterial challenges
    Evan F Lind
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario M5G 2C1, Canada
    J Immunol 190:1210-6. 2013
    ..These data suggest that mir-155 may be a good target for therapies aimed at modulating immune responses...
  24. doi A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice
    Erika Zonari
    San Raffaele Telethon Institute for Gene Therapy and Division of Regenerative Medicine, Gene Therapy and Stem Cells, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Blood 122:243-52. 2013
    ..This study highlights the importance of tumor-infiltrating hematopoietic cells in constraining carcinogenesis and establishes an antitumoral function of a prototypical oncomiR. ..
  25. pmc MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice
    Ashley M Miller
    Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 8:e72324. 2013
    ..Together these data indicate that miR-155 plays a pivotal role regulating lipid metabolism in liver and that its deregulation may lead to hepatic steatosis in patients with diabetes. ..
  26. pmc Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice
    Stefan Costinean
    Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Blood 114:1374-82. 2009
    ..We hypothesize that miR-155, by down-modulating Ship and C/EBPbeta, initiates a chain of events that leads to the accumulation of large pre-B cells and acute lymphoblastic leukemia/high-grade lymphoma...
  27. pmc microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells
    Elena Vigorito
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, CB22 3AT, UK
    Immunity 27:847-59. 2007
    ..The transcription factor Pu.1 is validated as a direct target of miR155-mediated inhibition. When Pu...
  28. pmc MicroRNA-155 is an Epstein-Barr virus-induced gene that modulates Epstein-Barr virus-regulated gene expression pathways
    Qinyan Yin
    Louisiana Cancer Research Consortium, New Orleans, USA
    J Virol 82:5295-306. 2008
    ..Together, these experiments suggest that the induction of miR-155 by EBV contributes to EBV-mediated signaling in part through the modulation of transcriptional regulatory factors...
  29. pmc MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase
    Grace Teng
    Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Immunity 28:621-9. 2008
    ..Thus, miR-155, which has recently been shown to play important roles in regulating the germinal-center reaction, does so in part by directly downmodulating AID expression...
  30. pmc MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation
    Yair Dorsett
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    Immunity 28:630-8. 2008
    ..A similar but more pronounced translocation phenotype was also found in miR-155-deficient mice. Our experiments indicate that miR-155 can act as a tumor suppressor by reducing potentially oncogenic translocations generated by AID...
  31. doi Regulation of B- and T-cell differentiation by a single microRNA
    Martin Turner
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK
    Biochem Soc Trans 36:531-3. 2008
    ..Microarray analysis of bic-deficient B- and T-cells under different conditions has revealed a wide spectrum of targets regulated by an miR-155 and suggested mechanisms for the regulation of lymphocyte differentiation by a single miR...
  32. pmc Requirement of bic/microRNA-155 for normal immune function
    Antony Rodriguez
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Science 316:608-11. 2007
    ..Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system...
  33. pmc MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
    William Kong
    Departments of Molecular Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, SRB3, Tampa, FL 33612, USA
    Mol Cell Biol 28:6773-84. 2008
    ..These data suggest that miR-155 may play an important role in TGF-beta-induced EMT and cell migration and invasion by targeting RhoA and indicate that it is a potential therapeutic target for breast cancer intervention...
  34. pmc Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein
    Li Fan Lu
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Immunity 30:80-91. 2009
    ..We found that Foxp3 controlled the elevated miR155 expression required for maintaining Treg cell proliferative activity and numbers under nonlymphopenic conditions...
  35. doi Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells
    Susan Kohlhaas
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    J Immunol 182:2578-82. 2009
    ..However, we found no evidence for defective suppressor activity of miR-155-deficient Tregs, either in vitro or in vivo. Our results indicate that miR-155 contributes to Treg development, but that additional miRNAs control Treg function...
  36. pmc Inositol phosphatase SHIP1 is a primary target of miR-155
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, 330 Braun, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 106:7113-8. 2009
    ..Our study unveils a molecular link between miR-155 and SHIP1 and provides evidence that repression of SHIP1 is an important component of miR-155 biology...
  37. doi LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages
    Tina Ruggiero
    RNA Technology Laboratory, Centro Biotecnologie Avanzate, Genoa, Italy
    FASEB J 23:2898-908. 2009
    ..Our studies unveil the existence of an LPS-dependent post-transcriptional regulation of miR-155 biogenesis. Once induced, miR-155 finely tunes the expression of select inflammation mediators in response to LPS...
  38. pmc Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF
    Jesper Worm
    Santaris Pharma, Kogle Alle 6, DK 2970 Hørsholm, Denmark
    Nucleic Acids Res 37:5784-92. 2009
    ....
  39. pmc Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells
    Arnob Banerjee
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Eur J Immunol 40:225-31. 2010
    ..These results identify IFN-gammaRalpha as a second miR-155 target in T cells and suggest that miR-155 contributes to Th1 differentiation in CD4+ T cells by inhibiting IFN-gamma signaling...
  40. ncbi Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA
    W Tam
    Department of Pathology, Joan and Sanford I Weill Medical College of Cornell University, K 508, 525 East 68th Street, New York, NY 10021, USA
    Gene 274:157-67. 2001
    ..Based on the lack of a conserved ORF and the evolutionary conservation of RNA secondary structure, we presume that BIC functions as a noncoding RNA...
  41. pmc Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis
    Deepak Rai
    Division of Hematology and Medical Oncology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 107:3111-6. 2010
    ..Together, our data helped explain miR-155 function, highlighted a hitherto unappreciated role of SMAD5 in lymphoma biology, and defined a unique mechanism used by cancer cells to escape TGF-beta's growth-inhibitory effects...
  42. ncbi Expression of the circulating and the tissue microRNAs after surgery, chemotherapy, and radiotherapy in mice mammary tumor
    Sadaf Farsinejad
    Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
    Tumour Biol 37:14225-14234. 2016
    ..It seems that the oncomiRs in the plasma can be an ideal noninvasive candidate biomarker for the early detection of breast cancer and also for following the response of the common therapies...
  43. pmc Latency locus complements MicroRNA 155 deficiency in vivo
    Sang Hoon Sin
    Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Virol 87:11908-11. 2013
    ..Germinal center (GC) formation was rescued in spleen, lymph node, and Peyer's patches. Immunoglobulin levels were restored. This demonstrates that KSHV can complement the normal, physiological function of miR-155. ..
  44. pmc Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis
    Robert B Lochhead
    Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 10:e0135142. 2015
    ..As reported previously, Mir155 was highly upregulated in joints from infected severely arthritic B6 Il10-/- mice, but not in mildly arthritic B6 ..
  45. pmc miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways
    Alexandre K Rouquette-Jazdanian
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 10:e0131823. 2015
    ..Furthermore, miR-155 regulates the delicate balance between PAK1-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function. ..
  46. doi Evaluation of Immunomodulatory Effects of Mesenchymal Stem Cells Soluble Factors on miR-155 and miR-23b Expression in Mice Dendritic Cells
    Aida Karachi
    Department of Pharmacology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
    Immunol Invest 44:427-37. 2015
    ..Production of TGF-β and IL-23 were not influenced by C.S. In conclusion, miR-23b is considered to be one of the mechanisms involved in tolerogenic DCs induction by C.S. in a time-dependent manner...
  47. doi MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation
    Sophia Chen
    Department of Hematology and Oncology, Freiburg University Medical Center
    Blood 126:103-12. 2015
    ..Inhibiting proinflammatory miR-155 by antagomir treatment could help reduce this complication of allo-HCT. ..
  48. doi MicroRNA-155 aggravates ischemia-reperfusion injury by modulation of inflammatory cell recruitment and the respiratory oxidative burst
    Steffen U Eisenhardt
    Department of Plastic and Handsurgery, University of Freiburg Medical Center, Freiburg, Germany
    Basic Res Cardiol 110:32. 2015
    ..In conclusion, miR-155 aggravates the inflammatory response, leukocyte infiltration and tissue damage in IRI via modulation of SOCS-1-dependent generation of ROS. MiR-155 is thus a potential target for the treatment or prevention of IRI...
  49. doi Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation
    Daniel Arango
    Department of Physiology and Cell Biology, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA Department of Molecular Genetics, The Ohio State University, Columbus, OH, USA Molecular Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH, USA
    Mol Nutr Food Res 59:763-72. 2015
    ..The aim of this study was to identify miRs involved in the anti-inflammatory activity of apigenin and apigenin-rich diets and determine their immune regulatory mechanisms in macrophages and in vivo...
  50. pmc Bone marrow progenitor cell therapy-mediated paracrine regulation of cardiac miRNA-155 modulates fibrotic response in diabetic hearts
    Raj Kishore
    Feinberg Cardiovascular Research Institute, School of Medicine, Northwestern University, Chicago, IL, USA
    PLoS ONE 8:e60161. 2013
    ..BMPCs release HGF, which inhibits miR-155-mediated profibrosis signaling, thereby preventing cardiac fibrosis. These data suggest that targeting miR-155 might serve as a potential therapy against cardiac fibrosis in the diabetic heart...
  51. pmc Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner
    Lin Wang
    Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cell Stem Cell 15:51-65. 2014
    ..Thus, the Notch/miR-155/κB-Ras1/NF-κB axis regulates the inflammatory state of the BM niche and affects the development of myeloproliferative disorders. ..
  52. doi MicroRNA-155 induction by Mycobacterium bovis BCG enhances ROS production through targeting SHIP1
    Jinli Wang
    Department of Immunology, Institute of Tuberculosis Control, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou 510080, China Key Laboratory of Tropical Diseases Control Sun Yat sen University, Ministry of Education, Guangzhou 510080, China
    Mol Immunol 62:29-36. 2014
    ..Collectively, these data indicate that miR-155 modulates ROS but not RNS production by targeting SHIP1, which may provide a better understanding of the host anti-mycobacterial response. ..
  53. doi Identification of a novel role of ESAT-6-dependent miR-155 induction during infection of macrophages with Mycobacterium tuberculosis
    Ranjeet Kumar
    Department of Chemistry, Bose Institute, Kolkata, India
    Cell Microbiol 14:1620-31. 2012
    ..Inhibition of miR-155 hindered survival of M.tb. in RAW264.7 and in murine BMDMs. Thus, our results offer new insights into the role of miRNAs in modulation of the host innate immune response by M.tb. for its own benefit...
  54. pmc Staphylococcal enterotoxin B-induced microRNA-155 targets SOCS1 to promote acute inflammatory lung injury
    Roshni Rao
    Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbus, South Carolina, USA
    Infect Immun 82:2971-9. 2014
    ....
  55. doi MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions
    Juliane Lescher
    Department of Neuropathology, University of Gottingen, Gottingen, Germany
    J Neuroimmunol 246:27-33. 2012
    ....
  56. doi MicroRNA-155 and MicroRNA-21 promote the expansion of functional myeloid-derived suppressor cells
    Limin Li
    Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, China
    J Immunol 192:1034-43. 2014
    ..These results demonstrate a novel miR-155/miR-21-based regulatory mechanism that modulates functional MDSC induction. ..
  57. doi Triptolide ameliorates ileocolonic anastomosis inflammation in IL-10 deficient mice by mechanism involving suppression of miR-155/SHIP-1 signaling pathway
    Rong Wu
    Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, PR China
    Mol Immunol 56:340-6. 2013
    ..Our data also suggested triptolide could suppress miR-155/SHIP-1 signaling pathway and attenuated expression of inflammatory cytokines in IL-10(-/-) mice performed ICR. ..
  58. doi Macrophage microRNA-155 promotes cardiac hypertrophy and failure
    Stephane Heymans
    Center for Heart Failure Research, Department of Cardiology S H, M F C, W V, P C, R E W v L, K C, T P, M H, M v B, A P P, B S, Department of Molecular Genetics L S, M P J d W, Department of Pathology E W, E L, Department of Pharmacology B J J, Department of Cardiology L J d W, and Department of Internal Medicine K W, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands S H Center for Molecular and Cardiovascular Biology, Department of Cardiovascular Sciences, Leuven, Belgium S H, P C, A P P Department of Medical Biochemistry L S, E L, M P J d W and Heart Failure Research Center E E C, Y M P, Academic Medical Center, Amsterdam
    Circulation 128:1420-32. 2013
    ..We recently reported that microRNA-155 is a key mediator of cardiac inflammation and injury in infectious myocarditis. Here, we investigated the impact of microRNA-155 manipulation in hypertensive heart disease...
  59. pmc MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer
    Jan C Dudda
    Ludwig Center for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 38:742-53. 2013
    ..Similarly, Mir155(-/-) CD8(+) T cells were ineffective at controlling tumor growth, whereas miRNA-155 overexpression enhanced the ..
  60. pmc Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155
    Carolyn L Zawislak
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 110:6967-72. 2013
    ..NK cells constitutively expressing Noxa and SOCS1 exhibit profound defects in expansion during the response to MCMV infection, suggesting that their regulation by miR-155 promotes antiviral immunity...
  61. doi Effects of tolerogenic dendritic cells generated by siRNA-mediated RelB silencing on immune defense and surveillance functions of T cells
    Lei Luo
    Department of Research and Education, Guizhou Province People s Hospital, Guiyang 550002, China
    Cell Immunol 282:28-37. 2013
    ..This study demonstrates that RelB-silenced DCs could induce donor-specific hyporesponsiveness and slightly impair immune surveillance of T cells, while retaining their immune defense functions...
  62. pmc STAT3 activates miR-155 in Th17 cells and acts in concert to promote experimental autoimmune uveitis
    Thelma Escobar
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 54:4017-25. 2013
    ..In our study, we used miR-155(-/-) mice and mice with targeted STAT3 deletion in T cells (CD4-STAT3KO) to investigate roles of miR-155 and STAT3 in the development of experimental autoimmune uveitis (EAU), a mouse model of human uveitis...
  63. pmc Antisense oligonucleotide treatment enhances the recovery of acute lung injury through IL-10-secreting M2-like macrophage-induced expansion of CD4+ regulatory T cells
    Zhongliang Guo
    Department of Respiratory Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China
    J Immunol 190:4337-48. 2013
    ....
  64. doi The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis
    Yuanyuan Wei
    Experimental Vascular Medicine, Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Pettenkoferstrasse 9, 80336 Munich, Germany
    Circulation 127:1609-19. 2013
    ..Because microRNAs (miRNAs) play a crucial role in cellular signaling by posttranscriptional regulation of gene expression, we studied the miRNA expression profiles during the progression of atherosclerosis...
  65. pmc BCL6 positively regulates AID and germinal center gene expression via repression of miR-155
    Katia Basso
    Institute for Cancer Genetics, Columbia University, New York, NY 10027, USA
    J Exp Med 209:2455-65. 2012
    ..These findings identify a novel mechanism by which BCL6, in addition to repressing protein coding genes, promotes the expression of important GC functions by repressing specific miRNAs...
  66. pmc MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression
    Ruozhen Hu
    Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
    J Immunol 190:5972-80. 2013
    ....
  67. pmc miR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2
    Chunliang Xu
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, Shanghai 200025, China
    J Biol Chem 288:11074-9. 2013
    ..Our data revealed a novel role of miR-155 in regulating the immune modulatory activities of MSCs...
  68. doi miR-155 modulates TNF-α-inhibited osteogenic differentiation by targeting SOCS1 expression
    Tingting Wu
    Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, Ninth People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Bone 51:498-505. 2012
    ..These findings may provide new insights into understanding the regulatory role of miR-155 in the process of osteogenic differentiation in inflammatory condition...
  69. doi MicroRNA changes in the mouse prefrontal cortex after inflammatory pain
    Kay Wee Poh
    Department of Oral and Maxillofacial Surgery, National University of Singapore, Singapore 119260, Singapore
    Eur J Pain 15:801.e1-12. 2011
    ..It is postulated that this could lead to increased inflammation and activation of the prefrontal cortex. Further studies are necessary to determine if specific miRNAs could be useful as therapeutic molecules for pain...
  70. pmc Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy
    Andrea L Kasinski
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nat Rev Cancer 11:849-64. 2011
    ..Here we discuss progress in using mouse models to understand the roles of miRNAs in cancer and the potential for manipulating miRNAs for cancer therapy as these molecules make their way towards clinical trials...
  71. pmc Regulation of acute graft-versus-host disease by microRNA-155
    Parvathi Ranganathan
    Division of Hematology, Department of Internal Medicine and Comprehensive Cancer Center, Ohio State University, 460 West 12th Ave, Columbus, OH 43210, USA
    Blood 119:4786-97. 2012
    ..Altogether, our data indicate a role for miR-155 in the regulation of GVHD and point to miR-155 as a novel target for therapeutic intervention in this disease...
  72. pmc Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma
    Imran A Babar
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 109:E1695-704. 2012
    ....
  73. ncbi [Expression and effects of microRNA-155 in the livers of septic mice]
    Zhong hua Wang
    Department of General Internal Medicine, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou510080, Guangdong, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 24:154-7. 2012
    ..To evaluate the effects of microRNA-155 (miR-155) on liver injury in mice with sepsis...
  74. doi Interferon-β-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF
    Jun Zhang
    Department of Orthopedics, Zhejiang Provincial People s Hospital, Hangzhou, PR China
    FEBS Lett 586:3255-62. 2012
    ..These findings have not only demonstrated that miR-155 inhibits osteoclast differentiation, but also provided a new therapeutic target for treatment of osteoclast-mediated diseases...
  75. pmc MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1
    Rui Yao
    Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China
    PLoS ONE 7:e46082. 2012
    ..Therefore, we demonstrated that miR-155 enhanced Treg and Th17 cells differentiation and IL-17A production by targeting SOCS1...
  76. ncbi Very early effect of DMBA and MNU on microRNA expression
    Krisztina Juhász
    Institute of Public Health, Faculty of Medicine, University of Pecs, Pecs, 12 Szigeti Str, 7624 Hungary
    In Vivo 27:113-7. 2013
    ..microRNA expression profile analysis provides evaluation of the early stages of carcinogenesis. This study focuses on early alteration of miRNA expression after treatment with different carcinogens...
  77. pmc miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model
    Sukhinder K Sandhu
    Department of Molecular Virology, Ohio State University Medical Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 109:20047-52. 2012
    ..Hence this study provides a better understanding of how miR-155 causes disruption of the BCL6 transcriptional machinery that leads to up-regulation of the survival and proliferation genes in miR-155-induced leukemias...
  78. pmc A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo
    Christine Dahlke
    Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
    PLoS ONE 7:e49435. 2012
    ....
  79. doi Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155
    Christine Boesch-Saadatmandi
    Institute of Human Nutrition and Food Science, Christian Albrechts University Kiel, 24098 Kiel, Germany
    J Nutr Biochem 22:293-9. 2011
    ..Finally, anti-inflammatory properties of quercetin were confirmed in vivo in mice fed quercetin-enriched diets (0.1 mg quercetin/g diet) over 6 weeks...
  80. pmc HOXA9 regulates miR-155 in hematopoietic cells
    Yu Long Hu
    Department of Medicine, Department of Veterans Affairs Medical Center and University of California, San Francisco, CA 94143, USA
    Nucleic Acids Res 38:5472-8. 2010
    ..Pu.1, an important regulator of myelopoiesis, was identified as a putative down stream target for miR-155. Although miR-155 was shown to down-regulate the Pu.1 protein, HOXA9 did not appear to modulate Pu.1 expression in murine BM cells...
  81. pmc Reprogramming of miRNA networks in cancer and leukemia
    Stefano Volinia
    Data Mining for Analysis of Microarrays, Department of Morphology and Embryology, Universita degli Studi, Ferrara 44100, Italy
    Genome Res 20:589-99. 2010
    ..Finally, we experimentally validated the miRNA network with acute lymphocytic leukemia originated in Mir155 transgenic mice...
  82. pmc Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu
    Anagha A Divekar
    Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 186:924-30. 2011
    ..Furthermore, simultaneous appearance of Dicer insufficiency and miR-155 overexpression in diseased mice suggests a Dicer-independent alternative mechanism of miRNA regulation under inflammatory conditions...
  83. pmc Efficient inhibition of miR-155 function in vivo by peptide nucleic acids
    Martin M Fabani
    Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Nucleic Acids Res 38:4466-75. 2010
    ..Interestingly, PNA also induced additional changes in gene expression. Our analysis provides a useful platform to aid the design of efficient and specific anti-miRNA ONs for in vivo use...
  84. doi Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function
    Isabelle Dunand-Sauthier
    Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Blood 117:4490-500. 2011
    ..There is growing evidence that microRNA-155 (miR155) modulates gene expression in various cell types of the immune system and is a prominent player in the regulation ..
  85. pmc miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT
    X Xiang
    James Graham Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA KY 40202, USA
    Oncogene 30:3440-53. 2011
    ....
  86. pmc MicroRNA155 is induced in activated CD4(+) T cells of TNBS-induced colitis in mice
    Da Fan Chen
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin second Road, Shanghai 200025, China
    World J Gastroenterol 16:854-61. 2010
    ..To investigate the expression of microRNA155 (miRNA155) in trinitrobenzene sulphonic acid (TNBS)-induced colitis and the relationship between miRNA155 and tumor necrosis factor (TNF) expressions...
  87. pmc MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia
    Ulrike Bruning
    School of Medicine and Medical Science and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Mol Cell Biol 31:4087-96. 2011
    ....
  88. pmc miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation
    Hee Young Seok
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 286:35339-46. 2011
    ..Our data therefore establish miR-155 as an important regulator of MEF2A expression and uncover its function in muscle gene expression and myogenic differentiation...
  89. pmc MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response
    Thomas J Cremer
    Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 4:e8508. 2009
    ..However, impaired miR-155 induction by SCHU S4 may help explain the lack of both SHIP down-regulation and pro-inflammatory response and may account for the virulence of Type A Francisella...
  90. pmc Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains
    Donald E Kuhn
    College of Pharmacy, Division of Pharmacology, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 285:1529-43. 2010
    ..Finally these results suggest that selective inactivation of Hsa21-derived miRNAs may provide a novel therapeutic tool in the treatment of DS...
  91. pmc miR-155 inhibition sensitizes CD4+ Th cells for TREG mediated suppression
    Heiko F Stahl
    Boehringer Ingelheim Pharma GmbH and Co KG, Respiratory Diseases Research, Genomics Group, Biberach an der Riss, Germany
    PLoS ONE 4:e7158. 2009
    ..Recent work using Dicer-deficient mice irrevocably demonstrated the importance of miRNAs for nTreg cell-mediated tolerance...
  92. pmc MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:14235-40. 2010
    ..Our study identifies an evolutionarily conserved subset of miRNAs that is expressed in HSCs and functions to modulate hematopoietic output...