Mitf

Summary

Gene Symbol: Mitf
Description: microphthalmia-associated transcription factor
Alias: BCC2, Bhlhe32, Gsfbcc2, Vitiligo, vit, microphthalmia-associated transcription factor, black eyed white, microphtalmia-associated transcription factor
Species: mouse

Top Publications

  1. ncbi Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein
    C A Hodgkinson
    Laboratory of Viral and Molecular Pathogenesis, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Cell 74:395-404. 1993
  2. ncbi Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1
    Masahito Matsumoto
    Department of Molecular Biology, Saitama Medical School, Saitama, Japan
    J Biol Chem 279:45969-79. 2004
  3. ncbi Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant
    C S Lee
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland 21210, USA
    Dev Biol 236:17-29. 2001
  4. pmc Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6
    Danielle Matsushima
    UNC Neuroscience Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Development 138:443-54. 2011
  5. pmc The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression
    Alexander Schepsky
    Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Mol Cell Biol 26:8914-27. 2006
  6. ncbi MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation
    Sudarshana M Sharma
    Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 282:15921-9. 2007
  7. ncbi Mitf and Tfe3: members of a b-HLH-ZIP transcription factor family essential for osteoclast development and function
    Christine L Hershey
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Bone 34:689-96. 2004
  8. ncbi The identification and functional characterization of a novel mast cell isoform of the microphthalmia-associated transcription factor
    Clifford M Takemoto
    Division of Pediatric Hematology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Biol Chem 277:30244-52. 2002
  9. pmc The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis
    Francesco Vetrini
    Telethon Institute of Genetics and Medicine TIGEM, Via P Castellino 111, 80131 Naples, Italy
    Mol Cell Biol 24:6550-9. 2004
  10. doi Lipopolysaccharide suppresses RANK gene expression in macrophages by down-regulating PU.1 and MITF
    Junko Ishii
    Department of Pathology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Japan
    J Cell Biochem 105:896-904. 2008

Research Grants

  1. Genetic networks that regulate the mast lineage
    Clifford Takemoto; Fiscal Year: 2009
  2. Site-specific transgenesis in zebrafish
    JAMES LISTER; Fiscal Year: 2008
  3. ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONS
    Janee Gelineau van Waes; Fiscal Year: 2003
  4. ChIP-ChIP-Chip: A New Tool To Study RPE Gene Regulation
    Noriko Esumi; Fiscal Year: 2007
  5. Molecular Mechanisms Regulating VMD2 Expression
    Noriko Esumi; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications148 found, 100 shown here

  1. ncbi Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein
    C A Hodgkinson
    Laboratory of Viral and Molecular Pathogenesis, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Cell 74:395-404. 1993
    ..The multiple spontaneous and induced mutations available at mi provide a unique biological resource for studying the role of a bHLH-ZIP protein in mammalian development...
  2. ncbi Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1
    Masahito Matsumoto
    Department of Molecular Biology, Saitama Medical School, Saitama, Japan
    J Biol Chem 279:45969-79. 2004
    ..These results suggest that the RANKL-induced cathepsin K gene expression is cooperatively regulated by the combination of the transcription factors and p38 MAP kinase in a gradual manner...
  3. ncbi Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant
    C S Lee
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland 21210, USA
    Dev Biol 236:17-29. 2001
    ..Furthermore, we provide evidence that the dorsal and ventral RPEs are maintained by distinct genetic components...
  4. pmc Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6
    Danielle Matsushima
    UNC Neuroscience Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Development 138:443-54. 2011
    ..Collectively, these results demonstrate that precise regulation of the ratio of SOX2 to PAX6 is necessary to ensure accurate progenitor cell specification, and place SOX2 as a decisive factor of neural competence in the retina...
  5. pmc The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression
    Alexander Schepsky
    Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Mol Cell Biol 26:8914-27. 2006
    ..lineage is characterized by the onset of expression of the microphthalmia-associated transcription factor (Mitf)...
  6. ncbi MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation
    Sudarshana M Sharma
    Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 282:15921-9. 2007
    Transcription factors NFATc1, PU.1, and MITF collaborate to regulate specific genes in response to colony-stimulating factor-1 (CSF-1) and receptor activator of NF-kappaB ligand (RANKL) signaling during osteoclast differentiation...
  7. ncbi Mitf and Tfe3: members of a b-HLH-ZIP transcription factor family essential for osteoclast development and function
    Christine L Hershey
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Bone 34:689-96. 2004
    The Microphthalmia-associated transcription factor (Mitf) is required for the proper development of several cell lineages including osteoclasts, melanocytes, retinal pigment epithelial cells, mast cells and natural killer cells...
  8. ncbi The identification and functional characterization of a novel mast cell isoform of the microphthalmia-associated transcription factor
    Clifford M Takemoto
    Division of Pediatric Hematology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Biol Chem 277:30244-52. 2002
    The microphthalmia-associated transcription factor (Mitf) is critical for mast cell development based on the severe mast cell deficiency seen in Mitf mutant mice...
  9. pmc The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis
    Francesco Vetrini
    Telethon Institute of Genetics and Medicine TIGEM, Via P Castellino 111, 80131 Naples, Italy
    Mol Cell Biol 24:6550-9. 2004
    ..We demonstrated that Oa1 is a target of Mitf and that this regulatory mechanism is conserved in the human gene...
  10. doi Lipopolysaccharide suppresses RANK gene expression in macrophages by down-regulating PU.1 and MITF
    Junko Ishii
    Department of Pathology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Japan
    J Cell Biochem 105:896-904. 2008
    ..A fragment of 1-kb from the transcription start sites containing four Sp-1 sites and putative binding sites for MITF, CRE/AP-1, and PU...
  11. ncbi Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation
    A Luchin
    Department of Molecular Genetics, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 276:36703-10. 2001
    The microphthalmia transcription factor (MITF), a basic-helix-loop-helix zipper factor, regulates distinct target genes in several cell types. We hypothesized that interaction with the Ets family factor PU...
  12. pmc Microphthalmia transcription factor isoforms in mast cells and the heart
    Sagi Tshori
    Department of Biochemistry, Hebrew University Medical School, Jerusalem 91120, Israel
    Mol Cell Biol 27:3911-9. 2007
    The microphthalmia transcription factor (Mitf) is critical for the survival and differentiation of a variety of cell types...
  13. pmc Expression of a soluble isoform of cell adhesion molecule 1 in the brain and its involvement in directional neurite outgrowth
    Man Hagiyama
    Division of Molecular Pathology, Department of Cancer Biology, Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Am J Pathol 174:2278-89. 2009
    ..These results show that sCADM1 appears to be involved in directional neurite extension by serving as an anchor to which membrane-bound CADM1 on the neurites can bind...
  14. pmc Deficient differentiation of mast cells in the skin of mi/mi mice. Usefulness of in situ hybridization for evaluation of mast cell phenotype
    T Kasugai
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Am J Pathol 143:1337-47. 1993
    ..The in situ hybridization of mRNA of mast cell-specific proteolytic enzymes seemed to be useful to describe abnormalities of mast cell differentiation in the skin of mi/mi mice...
  15. ncbi Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells
    E Razin
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Biol Chem 274:34272-6. 1999
    ..Its ability to suppres mi transcriptional activity in the transient transfected fibroblast system suggests that it can function in vivo as a negative regulator of mi-induced transcriptional activation...
  16. ncbi A mouse model for vitiligo
    A B Lerner
    J Invest Dermatol 87:299-304. 1986
    As the result of a long search for a depigmenting mouse that could serve as a model for the study of vitiligo, we have located a strain that arose from the C57BL/6J. Its provisional genetic designation is C57BL/6J Ler-vit/vit...
  17. ncbi Pmel17 expression is Mitf-dependent and reveals cranial melanoblast migration during murine development
    Laura L Baxter
    Mouse Embryology Section, Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Gene Expr Patterns 3:703-7. 2003
    ..5. Pmel17 expression is not detectable in embryos mutated for Microphthalmia-associated transcription factor (Mitf), demonstrating transcriptional dependence of Pmel17 on Mitf in the RPE...
  18. ncbi Mitf-PU.1 interactions with the tartrate-resistant acid phosphatase gene promoter during osteoclast differentiation
    G A Partington
    Department of Cellular and Molecular Medicine, St George s Hospital Medical School, London SW17 0RE, UK
    Bone 34:237-45. 2004
    It has been postulated that the transcription factors micropthalmia associated factor (Mitf) and PU.1 interact with the tartrate-resistant acid phosphatase (TRAP) gene promoter and activate TRAP gene expression in osteoclasts...
  19. pmc Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor
    Ling Lin
    Department of Internal Medicine Rheumatology, Washington University School of Medicine, Campus Box 8045, CSRB 6617, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:115-22. 2004
    ..Here, we show that the microphthalmia-associated transcription factor (Mitf) is highly expressed in naive B cells, where it antagonizes the process of terminal differentiation through the ..
  20. pmc Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors
    Rong Hu
    Department of Molecular and Cellular Biochemistry and Comprehensive Cancer Center, 370A Tzagournis Medical Research Facility, Ohio State University, 420 West 12th Avenue, Columbus, OH 43210, USA
    Mol Cell Biol 27:4018-27. 2007
    Transcription factors MITF and PU.1 collaborate to increase expression of target genes like cathepsin K (Ctsk) and acid phosphatase 5 (Acp5) during osteoclast differentiation...
  21. doi The mechanism of osteoclast differentiation induced by IL-1
    Jung Ha Kim
    National Research Laboratory for Regulation of Bone Metabolism and Disease, Medical Research Center for Gene Regulation, Brain Korea 21, Chonnam National University Medical School, Gwangju, Korea
    J Immunol 183:1862-70. 2009
    ..Rather, IL-1/IL-1RI strongly activates MITF, which subsequently induces osteoclast-specific genes such as osteoclast-associated receptor and tartrate-resistant ..
  22. ncbi Fusion disability of embryonic osteoclast precursor cells and macrophages in the microphthalmic osteopetrotic mouse
    C W Thesingh
    Bone 6:43-52. 1985
    ..We presume that in fully developed bone marrow, local factors are favorable for abolishing the fusion defect...
  23. ncbi Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences
    E Steingrimsson
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702
    Nat Genet 8:256-63. 1994
    ..Recently, mutations in the human mi gene (MITF) were found in patients with Waardenburg Syndrome type 2 (WS2), a dominantly inherited syndrome associated with ..
  24. ncbi A helix-loop-helix transcription factor-like gene is located at the mi locus
    M J Hughes
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Ohio 45267 0524
    J Biol Chem 268:20687-90. 1993
    ..Taken together, these data suggest that the gene encoding this new helix-loop-helix DNA-binding protein, and residing in the mi locus, is a strong candidate for the mi gene...
  25. ncbi In vivo and in vitro morphological analysis of melanocytes homozygous for the misp allele at the murine microphthalmia locus
    R E Boissy
    Department of Dermatology, University of Cincinnati College of Medicine 45267 0592, USA
    Pigment Cell Res 8:294-301. 1995
    ..These results demonstrate that while the misp allele has no obvious effect on the phenotype of the mouse, it does dramatically suppress the survival of melanocytes in normal culture conditions...
  26. ncbi Macrophage function in mice with a mutation at the microphthalmia (mi) locus
    P J Rohan
    Department of Medicine, University of Kansas Medical Center, Kansas City 66160 7317, USA
    Proc Soc Exp Biol Med 215:269-74. 1997
    ..The mi mutation, therefore, is associated with reduced macrophage SOD activity, increased O2- and NO production, and enhanced capacity for tumor cell killing. The molecular mechanisms for these changes have not been identified...
  27. ncbi Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently
    A Nakayama
    Laboratory of Developmental Neurogenetics, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Mech Dev 70:155-66. 1998
    The mouse microphthalmia (Mitf) gene encodes a basic-helix-loop-helix-zipper transcription factor whose mutations are associated with abnormalities in neuroepithelial and neural crest-derived melanocytes...
  28. ncbi Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium
    S Amae
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Miyagi, Japan
    Biochem Biophys Res Commun 247:710-5. 1998
    Mutations at the mouse locus encoding microphthalmia-associated transcription factor (Mitf) affect the development of many cell types, including retinal pigment epithelium (RPE), melanocytes, mast cells, and osteoclasts...
  29. ncbi Transient overexpression of the Microphthalmia gene in the eyes of Microphthalmia vitiligo mutant mice
    N Bora
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta 30912 2000, USA
    Dev Dyn 213:283-92. 1998
    ..One of the mildest of these is the Mitf vitiligo (Mitfvit) mutant allele, which exhibits uneven pigmentation of the retinal pigment epithelium (RPE) and slow, ..
  30. ncbi Involvement of mi-transcription factor in expression of alpha-melanocyte-stimulating hormone receptor in cultured mast cells of mice
    S Adachi
    Department of Pathology, Osaka University Medical School, Suita, Japan
    J Immunol 164:855-60. 2000
    ..encodes a member of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (MITF)...
  31. ncbi Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF
    L Hou
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Development 127:5379-89. 2000
    ..depends on the tyrosine kinase receptor KIT and the basic-helix-loop-helix-leucine zipper transcription factor MITF. KIT and MITF show complex interactions in that MITF is needed for the maintenance of Kit expression in ..
  32. pmc The transcription factor Sox10 is a key regulator of peripheral glial development
    S Britsch
    Max Delbruck Center for Molecular Medicine, D 13122 Berlin, Germany
    Genes Dev 15:66-78. 2001
    ..Haploinsufficiency of Sox10 can thus cause pigmentation and megacolon defects, which are also observed in Sox10(Dom)/+ mice and in patients with Waardenburg-Hirschsprung disease caused by heterozygous SOX10 mutations...
  33. ncbi Specific Pax-6/microphthalmia transcription factor interactions involve their DNA-binding domains and inhibit transcriptional properties of both proteins
    N Planque
    CNRS UMR 146, Institut Curie Section Recherche, Centre Universitaire Bâtiment 110, 91405 Orsay Cedex, France
    J Biol Chem 276:29330-7. 2001
    Pax-6 and microphthalmia transcription factor (Mitf) are required for proper eye development. Pax-6, expressed in both the neuroretina and pigmented retina, has two DNA-binding domains: the paired domain and the homeodomain...
  34. pmc Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Proc Natl Acad Sci U S A 99:4477-82. 2002
    The Mitf-Tfe family of basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factors encodes four family members: Mitf, Tfe3, Tfeb, and Tfec...
  35. ncbi Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche
    Emi K Nishimura
    Department of Pediatric Hematology Oncology, Melanoma Program in Medical Oncology, Dana Farber Cancer Institute, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 307:720-4. 2005
    ..Furthermore, physiologic aging of melanocyte stem cells was associated with ectopic pigmentation or differentiation within the niche, a process accelerated by mutation of the melanocyte master transcriptional regulator Mitf.
  36. pmc Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation
    Claudia Wellbrock
    Signal Transduction Team, Cancer Research UK Centre of Cell and Molecular Biology, The Institute of Cancer Research, London SW3 6JB, England, UK
    J Cell Biol 170:703-8. 2005
    ..Microphthalmia-associated transcription factor (MITF) is an important melanocyte differentiation and survival factor, but its role in melanoma is unclear...
  37. pmc Interspecies difference in the regulation of melanocyte development by SOX10 and MITF
    Ling Hou
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9081-5. 2006
    ..In both zebrafish and mice, one transcription factor, SOX10, controls the expression of another, MITF (microphthalmia-associated transcription factor), which in turn regulates a set of genes critical for pigment cell ..
  38. ncbi Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene
    M Tassabehji
    Department of Medical Genetics, St Mary s Hospital, Manchester, UK
    Nat Genet 8:251-5. 1994
    ..We recently mapped a WS2 gene to chromosome 3p12.3-p14.1 and proposed as a candidate gene MITF, the human homologue of the mouse microphthalmia (mi) gene...
  39. ncbi microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family
    T J Hemesath
    Division of Pediatric Hematology Oncology, Dana Farber Cancer Institute, Boston, Massachusetts
    Genes Dev 8:2770-80. 1994
    ..These findings suggest that Mi's critical roles in melanocyte survival and pigmentation are mediated by MiT family interactions and transcriptional activities...
  40. ncbi Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice
    T Tsujimura
    Department of Pathology, Medical School, Osaka University, Suita, Japan
    Blood 88:1225-33. 1996
    ..of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (hereafter called MITF)...
  41. ncbi Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
    Nature 383:407-13. 1996
    ..Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centres...
  42. ncbi Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor
    K Opdecamp
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Development 124:2377-86. 1997
    The more than 20 different Mitf mutations in the mouse are all associated with deficiencies in neural crest-derived melanocytes that range from minor functional disturbances with some alleles to complete absence of mature melanocytes with ..
  43. ncbi MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
    T J Hemesath
    Division of Pediatric Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 391:298-301. 1998
    ..The pathway represents a new application of the general MAP kinase machinery in transducing a signal between a tissue-specific receptor at the cell surface and a tissue-specific transcription factor in the nucleus...
  44. pmc Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo
    I Aksan
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Mol Cell Biol 18:6930-8. 1998
    ....
  45. ncbi Microphthalmic mice display a B cell deficiency similar to that seen for mast and NK cells
    K Roundy
    Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City 84132, USA
    J Immunol 163:6671-8. 1999
    ..Therefore, the block in cellular differentiation must be within the marrow environment, which is essential for maturing B cells, NK cells, and MC but not T cells...
  46. ncbi Dorsal retinal pigment epithelium differentiates as neural retina in the microphthalmia (mi/mi) mouse
    K M Bumsted
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA
    Invest Ophthalmol Vis Sci 41:903-8. 2000
    ..To determine a role for microphthalmia (mi) during eye development, the effects of an mi loss of function mutation on RPE and neural retinal were investigated in the mi/mi mouse...
  47. ncbi Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage
    C R Goding
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, The Chart, Oxted Surrey, RH8 OTL, UK
    Genes Dev 14:1712-28. 2000
  48. ncbi Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF
    M Nguyen
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Development 127:3581-91. 2000
    ..is associated with the initial coexpression of the basic-helix-loop-helix-zipper transcription factor MITF, which is later needed solely in the pigmented epithelium, and a set of distinct transcription factors that become ..
  49. ncbi Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3
    S B Potterf
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4472, USA
    Hum Genet 107:1-6. 2000
    ..with neural crest-derived melanocyte deficiency caused by mutations in either one of three transcription factors: MITF, PAX3, and SOX10. However, the hierarchical relationship of these transcription factors is largely unknown...
  50. ncbi Transcription factors in melanocyte development: distinct roles for Pax-3 and Mitf
    T J Hornyak
    The Ronald O Perelman Department of Dermatology, New York University Medical Center, NY 10016, New York, USA
    Mech Dev 101:47-59. 2001
    A transgenic mouse model was used to examine the roles of the murine transcription factors Pax-3 and Mitf in melanocyte development...
  51. ncbi Importance of leucine zipper domain of mi transcription factor (MITF) for differentiation of mast cells demonstrated using mi(ce)/mi(ce) mutant mice of which MITF lacks the zipper domain
    E Morii
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Blood 97:2038-44. 2001
    The mi transcription factor (MITF) is a basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factor that is important for the development of mast cells...
  52. ncbi Otx genes are required for tissue specification in the developing eye
    J R Martinez-Morales
    Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 128:2019-30. 2001
    ..optic vesicle infolding was severely altered and the expression of pigment epithelium-specific genes, such as Mitf or tyrosinase, was lost...
  53. ncbi Analysis of SOX10 function in neural crest-derived melanocyte development: SOX10-dependent transcriptional control of dopachrome tautomerase
    S B Potterf
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Dev Biol 237:245-57. 2001
    ..homozygous for the Sox10(Dom) mutation entirely lack neural crest-derived cells expressing the lineage marker KIT, MITF, or DCT. Moreover, neural crest cell cultures derived from homozygous embryos do not give rise to pigmented cells...
  54. ncbi Linkage of M-CSF signaling to Mitf, TFE3, and the osteoclast defect in Mitf(mi/mi) mice
    K N Weilbaecher
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell 8:749-58. 2001
    ..b>Mitf and TFE3 are two closely related helix-loop-helix (HLH) transcription factors previously implicated in osteoclast ..
  55. ncbi Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling
    Kim C Mansky
    Department of Molecular Genetics and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 277:11077-83. 2002
    ..The microphthalmia transcription factor (MITF) is required for terminal differentiation of osteoclasts...
  56. ncbi Mitf-D, a newly identified isoform, expressed in the retinal pigment epithelium and monocyte-lineage cells affected by Mitf mutations
    Kazuhisa Takeda
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Biochim Biophys Acta 1574:15-23. 2002
    Microphthalmia-associated transcription factor (Mitf) regulates the differentiation of melanocytes, optic cup-derived retinal pigment epithelium (RPE), and some types of bone marrow-derived cells...
  57. ncbi Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
    Gael G McGill
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 109:707-18. 2002
    Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken...
  58. ncbi Glycogen synthase kinase 3beta is activated by cAMP and plays an active role in the regulation of melanogenesis
    Mehdi Khaled
    INSERM U385, Biologie et Physiopathologie de la Peau, IFR 50, 28 Avenue de Valombrose, 06107 Nice Cedex 2, France
    J Biol Chem 277:33690-7. 2002
    ..the activation of protein kinase A, increases the expression of microphthalmia-associated transcription factor (MITF), which in turn stimulates tyrosinase gene expression, to allow melanin synthesis...
  59. ncbi Microphthalmia-associated transcription factor in the Wnt signaling pathway
    Hideo Saito
    Department of Molecular Biology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi, Japan
    Pigment Cell Res 16:261-5. 2003
    Microphthalmia-associated transcription factor (MITF) contains a basic helix-loop-helix and leucine-zipper (bHLH-LZ) structure and consists of many isoforms with different N-termini...
  60. ncbi Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6
    Nicole Baumer
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Development 130:2903-15. 2003
    ..Pax2; Pax6 compound mutants display a dose-dependent reduction in the expression of the melanocyte determinant Mitf, accompanied by transdifferentiation of retinal pigmented epithelium (RPE) into neuroretina (NR) in Pax2(-/-); Pax6(..
  61. ncbi Microphthalmia associated transcription factor is a target of the phosphatidylinositol-3-kinase pathway
    Mehdi Khaled
    INSERM U385, Biologie et Physiopathologie de la Peau, Nice, France
    J Invest Dermatol 121:831-6. 2003
    ..melanogenic enzymes, tyrosinase and Tyrp1, through a transcriptional mechanism that involves microphthalmia associated transcription factor, a basic helix-loop-helix transcription factor, which plays a key role in melanocyte survival ..
  62. ncbi Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma
    Arlo J Miller
    Dana Farber Cancer Institute and Children s Hospital, Department of Pediatric Hematology Oncology, Boston, Massachusetts, USA
    Cancer Res 64:509-16. 2004
    ..Similarly, the melanocytic markers MLANA/MART1 and MITF also have been shown to lose relative expression during melanoma progression...
  63. ncbi Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity
    D Jonathan Horsford
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 132:177-87. 2005
    ..the transcription factor Chx10, or retinal pigment epithelium (RPE) progenitors expressing the transcription factor Mitf. Chx10 mutations lead to microphthalmia and impaired neuroretinal proliferation...
  64. ncbi Genomic analysis of the Microphthalmia locus and identification of the MITF-J/Mitf-J isoform
    Christine L Hershey
    Division of Pediatric Hematology Oncology and Melanoma Program in Medical Oncology, Dana Farber Cancer Institute and Children s Hospital, Harvard Medical School, 44 Binney Street, Dana 630, Boston, MA 02115, USA
    Gene 347:73-82. 2005
    ..Waardenburg Syndrome Type 2 is caused by mutations in the human Microphthalmia-associated transcription factor (MITF) gene...
  65. ncbi Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 OTL, UK
    Nature 433:764-9. 2005
    ..The microphthalmia-associated transcription factor Mitf has a crucial but poorly defined role in melanoblast and melanocyte survival and in differentiation...
  66. pmc Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner
    Hideki Murakami
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Pigment Cell Res 18:265-77. 2005
    The microphthalmia transcription factor MITF plays important roles in several cell lineages including retinal and neural crest-derived pigment cells...
  67. pmc Multiple requirements for Hes 1 during early eye formation
    Hae Young Lee
    Department of Pediatrics, Northwestern University Medical School at Children s Memorial Institute for Education and Research, Chicago, IL 60614, USA
    Dev Biol 284:464-78. 2005
    ..Together, these studies demonstrate that Hes1, like Pax6, simultaneously regulates multiple developmental processes during optic development...
  68. pmc Genetic evidence does not support direct regulation of EDNRB by SOX10 in migratory neural crest and the melanocyte lineage
    Ramin Mollaaghababa Hakami
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4472, USA
    Mech Dev 123:124-34. 2006
    ..Given that SOX10 directly activates Ednrb in the enteric nervous system, our results suggest that SOX10 may differentially activate target genes based on the particular cellular context...
  69. pmc Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors
    Agnieszka Bronisz
    Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Mol Biol Cell 17:3897-906. 2006
    The microphthalmia-associated transcription factor (MITF) is required for terminal osteoclast differentiation and is a target for signaling pathways engaged by colony stimulating factor (CSF)-1 and receptor-activator of nuclear factor-..
  70. ncbi Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH
    Julian Morcillo
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 133:3179-90. 2006
    ..Collectively, these data indicate that BMP7 is required for retinal fissure formation and that its activity is needed, before SHH signalling, for the generation of PAX2-positive cells at the optic disc...
  71. pmc Transcription factor MITF regulates cardiac growth and hypertrophy
    Sagi Tshori
    Department of Biochemistry, Hebrew University Medical School, Jerusalem, Israel
    J Clin Invest 116:2673-81. 2006
    High levels of microphthalmia transcription factor (MITF) expression have been described in several cell types, including melanocytes, mast cells, and osteoclasts...
  72. ncbi Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB
    Bidisha Saha
    Department of Cellular Biochemistry, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    Pigment Cell Res 19:595-605. 2006
    ..The results are relevant for the regulation of melanocytes by Mitf, but also raise the possibility that lipid mediated activation of p38 signalling may represent a potential therapy for vitiligo.
  73. pmc Distinct and shared transcriptomes are regulated by microphthalmia-associated transcription factor isoforms in mast cells
    Amir H Shahlaee
    Division of Pediatric Hematology, Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 178:378-88. 2007
    The Microphthalmia-associated transcription factor (Mitf) is an essential basic helix-loop-helix leucine zipper transcription factor for mast cell development...
  74. ncbi The tyrosinase enhancer is activated by Sox10 and Mitf in mouse melanocytes
    Fabien Murisier
    Swiss Institute for Experimental Cancer Research ISREC, National Center of Competence in Research NCCR Molecular Oncology, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Pigment Cell Res 20:173-84. 2007
    ..Pigment cell-specific transcription factors, such as Mitf, as well as specific proximal and distal regulatory elements (DRE) are implicated in the tight control of ..
  75. ncbi Evolutionary sequence comparison of the Mitf gene reveals novel conserved domains
    Jón Hallsteinn Hallsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Pigment Cell Res 20:185-200. 2007
    The microphthalmia-associated transcription factor (MITF) is a member of the MYC family of basic helix-loop-helix leucine zipper transcription factors...
  76. pmc Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF
    Kapil Bharti
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:1169-78. 2008
    During vertebrate eye development, the transcription factor MITF plays central roles in neuroepithelial domain specification and differentiation of the retinal pigment epithelium...
  77. doi Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport
    Christine Chiaverini
    INSERM U895, Biologie et Pathologies des Cellules Mélanocytaires de la Pigmentation Cutanée au Mélanome 28, Avenue de Valombrose, 06107 Nice Cedex 2, France
    J Biol Chem 283:12635-42. 2008
    ..In this study, we show that microphthalmia-associated transcription factor (MITF) silencing induces melanosome gathering around the nucleus and causes the relocalization of Rab27A, Slac2a-Mlph, ..
  78. pmc The transcription factor Sox5 modulates Sox10 function during melanocyte development
    C Claus Stolt
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Nucleic Acids Res 36:5427-40. 2008
    ..Both binding site competition and recruitment of corepressors thus help Sox5 to modulate the activity of Sox10 in the melanocyte lineage...
  79. pmc Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells
    Gaurav Das
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Neural Dev 4:15. 2009
    ..How cyclin D1 influences RPC behavior, especially during the embryonic period, is unclear...
  80. pmc Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression
    Peter Westenskow
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Development 136:2505-10. 2009
    ..The transcription factors microphthalmia-associated transcription factor (Mitf) and orthodenticle homolog 2 (Otx2) are crucial for RPE development and function; however, very little is known ..
  81. doi Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium
    Naoko Fujimura
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Dev Biol 334:31-45. 2009
    ..in transdifferentiation of RPE to neural retina (NR) as documented by downregulation of RPE-specific markers Mitf and Otx2 and ectopic expression of NR-specific markers Chx10 and Rx, respectively...
  82. pmc A genomic screen identifies TYRO3 as a MITF regulator in melanoma
    Shoutian Zhu
    The Skaggs Institute of Chemical Biology and The Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:17025-30. 2009
    ..Microphthalmia-associated transcription factor (MITF) is a master gene regulating melanocyte development and functions as a "lineage addiction" oncogene in malignant ..
  83. pmc COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis
    Ke Tang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Development 137:725-34. 2010
    ..the expression of several regulatory genes essential for early optic vesicle development, including Pax6, Otx2, Mitf, Pax2 and Vax1/2, is altered in the corresponding compartments of the mutant eye...
  84. pmc Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development
    Zhigang Cai
    Department of Medical and Molecular Genetics, Stark Neuroscience Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci 30:4110-9. 2010
    ..Together, these results demonstrate that Shp2 mediates FGF-Ras signaling to control retinal progenitor cell fate...
  85. pmc Lineage-specific transcriptional regulation of DICER by MITF in melanocytes
    Carmit Levy
    Department of Dermatology, Cutaneous Biology Research Center, Mass General Hospital, Harvard Medical School, MA 02115, USA
    Cell 141:994-1005. 2010
    ..found to occur via direct transcriptional targeting of DICER by the melanocyte master transcriptional regulator MITF. MITF binds and activates a conserved regulatory element upstream of DICER's transcriptional start site upon ..
  86. pmc A role for ATF2 in regulating MITF and melanoma development
    Meera Shah
    Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS Genet 6:e1001258. 2010
    ..Gene expression profiling identified higher MITF expression in primary melanocytes expressing transcriptionally inactive ATF2...
  87. pmc HDAC3 and HDAC7 have opposite effects on osteoclast differentiation
    Lan Pham
    Department of Developmental and Surgical Science, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    J Biol Chem 286:12056-65. 2011
    ..b>Mitf, a transcription factor, is necessary for osteoclast differentiation...
  88. ncbi Interpretation of complex phenotypes: lessons from the Mitf gene
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology and BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Pigment Cell Melanoma Res 23:736-40. 2010
    ..An excellent example is provided by the microphthalmia (Mitf) locus in the mouse...
  89. pmc A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development
    Kapil Bharti
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002757. 2012
    ..is seen, however, only in a background genetically sensitized by mutations in the pigment cell transcription factor MITF. In fact, a reduction in Pax6 gene dose exacerbates the RPE-to-retina transdifferentiation seen in embryos ..
  90. pmc PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF
    Shaul Raviv
    Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS Genet 10:e1004360. 2014
    ..mutagenesis of Pax6 in the differentiating RPE revealed that PAX6 functions in a feed-forward regulatory loop with MITF during onset of melanogenesis...
  91. ncbi Loss of DNA binding ability of the transcription factor encoded by the mutant mi locus
    E Morii
    Department of Pathology, Osaka University Medical School, Japan
    Biochem Biophys Res Commun 205:1299-304. 1994
    ..mice encodes a novel member of the basic-helix-loop-helix-leucine zipper protein family of transcription factors (MITF)...
  92. pmc The recessive phenotype displayed by a dominant negative microphthalmia-associated transcription factor mutant is a result of impaired nucleation potential
    K Takebayashi
    Department of Pathology, Osaka University Medical School, Suita, Osaka, Japan
    Mol Cell Biol 16:1203-11. 1996
    In the DNA binding domain of microphthalmia-associated transcription factor (MITF), four mutations are reported: mi, Mi wh, mi ew, and mi or...
  93. ncbi Regulation of mouse mast cell protease 6 gene expression by transcription factor encoded by the mi locus
    E Morii
    Department of Pathology, Osaka University Medical School, Japan
    Blood 88:2488-94. 1996
    ..of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (hereafter called MITF)...
  94. ncbi Involvement of transcription factor encoded by the mouse mi locus (MITF) in expression of p75 receptor of nerve growth factor in cultured mast cells of mice
    T Jippo
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Blood 90:2601-8. 1997
    ..of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (hereafter called MITF). Cultured mast cells (CMCs) of mi/mi genotype showed a poor response to nerve growth factor (NGF)...
  95. pmc Involvement of transcription factor encoded by the mouse mi locus (MITF) in apoptosis of cultured mast cells induced by removal of interleukin-3
    T Tsujimura
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Am J Pathol 151:1043-51. 1997
    ..We obtained CMCs from tg/tg mice that did not express the transcription factor encoded by the mi gene (MITF) due to the integration of a transgene at its 5' flanking region...
  96. ncbi Abnormal expression of mouse mast cell protease 5 gene in cultured mast cells derived from mutant mi/mi mice
    E Morii
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Blood 90:3057-66. 1997
    ..of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (hereafter called MITF). The consensus sequence recognized and bound by bHLH-Zip transcription factors is CANNTG...
  97. ncbi Systematic method to obtain novel genes that are regulated by mi transcription factor: impaired expression of granzyme B and tryptophan hydroxylase in mi/mi cultured mast cells
    A Ito
    Department of Pathology, Medical School, Osaka University, Suita, Osaka 565, Japan
    Blood 91:3210-21. 1998
    ..a member of the basic-helix-loop-helix-leucine zipper protein family of transcription factors (hereafter called MITF)...
  98. ncbi Inhibitory effect of the transcription factor encoded by the mi mutant allele in cultured mast cells of mice
    A Ito
    Department of Pathology, Osaka University Medical School, Suita, Osaka, Japan
    Blood 93:1189-96. 1999
    The mi locus of mice encodes a transcription factor of the basic-helix-loop-helix-leucine zipper protein family (MITF). The MITF encoded by the mutant mi allele (mi-MITF) deletes 1 of 4 consecutive arginines in the basic domain...
  99. ncbi Different effect of various mutant MITF encoded by mi, Mior, or Miwh allele on phenotype of murine mast cells
    D K Kim
    Department of Pathology, Osaka University Medical School, Osaka, Japan the Department of Pharmacology, Ehime University Medical School, Ehime, Japan
    Blood 93:4179-86. 1999
    ..a member of the basic-helix-loop-helix-leucine zipper protein family of transcription factors (hereafter called MITF). Mutant alleles of mi, Mior, and Miwh are deletion or point mutation of the basic domain by which MITF binds DNA...
  100. ncbi An L1 element intronic insertion in the black-eyed white (Mitf[mi-bw]) gene: the loss of a single Mitf isoform responsible for the pigmentary defect and inner ear deafness
    I Yajima
    Biological Institute, Graduate School of Science, Tohoku University, Sendai, Miyagi 980 8578, Japan
    Hum Mol Genet 8:1431-41. 1999
    ..20% of WS2 cases are associated with mutations in the gene encoding microphthalmia-associated transcription factor (MITF)...
  101. ncbi Effect of a large deletion of the basic domain of mi transcription factor on differentiation of mast cells
    E Morii
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Blood 98:2577-9. 2001
    The mi transcription factor (MITF) is a basic-helix-loop-helix-leucine zipper transcription factor that is important for the development of mast cells...

Research Grants5

  1. Genetic networks that regulate the mast lineage
    Clifford Takemoto; Fiscal Year: 2009
    ..The microphthalmia-associated transcription factor (Mitf) is essential for the development of mast cells;our laboratory has recently cloned and characterized a novel ..
  2. Site-specific transgenesis in zebrafish
    JAMES LISTER; Fiscal Year: 2008
    ..These tools will advance the usefulness of this model organism as a model for human development and disease. [unreadable] [unreadable] [unreadable]..
  3. ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONS
    Janee Gelineau van Waes; Fiscal Year: 2003
    ..abstract_text> ..
  4. ChIP-ChIP-Chip: A New Tool To Study RPE Gene Regulation
    Noriko Esumi; Fiscal Year: 2007
    ..Finally, I will begin the process of identifying in vivo direct targets of microphthalmia associated transcription factor (MITF) using the genomic microarray and probes selected by the second ChIP with anti-MITF ..
  5. Molecular Mechanisms Regulating VMD2 Expression
    Noriko Esumi; Fiscal Year: 2009
    ..to direct RPE-specific expression in transgenic mice and identified microphthalmia-associated transcription factor (MITF) as a potential positive regulator. The goal of this proposal is to extend these findings...