Myf5

Summary

Gene Symbol: Myf5
Description: myogenic factor 5
Alias: B130010J22Rik, Myf-5, bHLHc2, myogenic factor 5, myogenic regulatory factor MYF-5
Species: mouse

Top Publications

  1. ncbi MyoD or Myf-5 is required for the formation of skeletal muscle
    M A Rudnicki
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    Cell 75:1351-9. 1993
  2. pmc Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal
    Rana Abou-Khalil
    INSERM, U955, Creteil, France
    Cell Stem Cell 5:298-309. 2009
  3. ncbi Early myotome specification regulates PDGFA expression and axial skeleton development
    M D Tallquist
    Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Development 127:5059-70. 2000
  4. pmc Dlk1 is necessary for proper skeletal muscle development and regeneration
    Jolena N Waddell
    Department of Animal Sciences, Purdue University, West Lafayette, Indiana, USA
    PLoS ONE 5:e15055. 2010
  5. pmc PRDM16 controls a brown fat/skeletal muscle switch
    Patrick Seale
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nature 454:961-7. 2008
  6. ncbi A Pax3/Pax7-dependent population of skeletal muscle progenitor cells
    Frederic Relaix
    C N R S URA 2578, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
    Nature 435:948-53. 2005
  7. pmc Sca-1 expression is required for efficient remodeling of the extracellular matrix during skeletal muscle regeneration
    Kimberly A Kafadar
    Emory University, Department of Pharmacology, Atlanta, GA 30322, USA
    Dev Biol 326:47-59. 2009
  8. ncbi Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo
    M O Ott
    Department of Molecular Biology, CNRS UA 1148, Pasteur Institute, Paris, France
    Development 111:1097-107. 1991
  9. pmc Cooperative activity of noggin and gremlin 1 in axial skeleton development
    David A Stafford
    Department of Molecular and Cell Biology and Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Development 138:1005-14. 2011
  10. ncbi Beta catenin-independent activation of MyoD in presomitic mesoderm requires PKC and depends on Pax3 transcriptional activity
    Silvia Brunelli
    Stem Cell Research Institute, H San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    Dev Biol 304:604-14. 2007

Research Grants

  1. Molecular Mechanisms Regulating Stem Cell Plasticity
    Michael Rudnicki; Fiscal Year: 2004

Scientific Experts

Detail Information

Publications136 found, 100 shown here

  1. ncbi MyoD or Myf-5 is required for the formation of skeletal muscle
    M A Rudnicki
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    Cell 75:1351-9. 1993
    ....
  2. pmc Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal
    Rana Abou-Khalil
    INSERM, U955, Creteil, France
    Cell Stem Cell 5:298-309. 2009
    ..We propose that Ang1/Tie-2 signaling regulates mpc self-renewal by controlling the return to quiescence of a subset of satellite cells...
  3. ncbi Early myotome specification regulates PDGFA expression and axial skeleton development
    M D Tallquist
    Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Development 127:5059-70. 2000
    Reciprocal defects in signaling between the myotome and the sclerotome compartments of the somites in PDGFRalpha and Myf5 mutant embryos lead to alterations in the formation of the vertebrae and the ribs...
  4. pmc Dlk1 is necessary for proper skeletal muscle development and regeneration
    Jolena N Waddell
    Department of Animal Sciences, Purdue University, West Lafayette, Indiana, USA
    PLoS ONE 5:e15055. 2010
    ....
  5. pmc PRDM16 controls a brown fat/skeletal muscle switch
    Patrick Seale
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nature 454:961-7. 2008
    ..Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage...
  6. ncbi A Pax3/Pax7-dependent population of skeletal muscle progenitor cells
    Frederic Relaix
    C N R S URA 2578, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
    Nature 435:948-53. 2005
    ....
  7. pmc Sca-1 expression is required for efficient remodeling of the extracellular matrix during skeletal muscle regeneration
    Kimberly A Kafadar
    Emory University, Department of Pharmacology, Atlanta, GA 30322, USA
    Dev Biol 326:47-59. 2009
    ..Further elucidation of the role of Sca-1 in matrix remodeling may aid in the development of novel therapeutic strategies for the treatment of fibrotic diseases...
  8. ncbi Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo
    M O Ott
    Department of Molecular Biology, CNRS UA 1148, Pasteur Institute, Paris, France
    Development 111:1097-107. 1991
    ..by in situ hybridization the expression of myf-5, the murine homologue of the human myogenic regulatory sequence myf5, during embryogenesis in the mouse...
  9. pmc Cooperative activity of noggin and gremlin 1 in axial skeleton development
    David A Stafford
    Department of Molecular and Cell Biology and Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Development 138:1005-14. 2011
    ..By contrast, Pax3, Myf5 and Lbx1 expression indicates that dermomyotome induction occurs in Nog;Grem1 double mutants...
  10. ncbi Beta catenin-independent activation of MyoD in presomitic mesoderm requires PKC and depends on Pax3 transcriptional activity
    Silvia Brunelli
    Stem Cell Research Institute, H San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    Dev Biol 304:604-14. 2007
    ..Canonical beta-catenin dependent Wnt signalling preferentially activates Myf5. We now show, in explant experiments with presomitic mesoderm, that the expression of another myogenic ..
  11. pmc Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs
    Julien Giordani
    Département de Génétique et Développement, Institut Cochin, Universite Paris Descartes, Paris, France
    Proc Natl Acad Sci U S A 104:11310-5. 2007
    b>Myf5, a member of the myogenic regulatory factor family, plays a major role in determining myogenic cell fate at the onset of skeletal muscle formation in the embryo...
  12. pmc Flt-1 haploinsufficiency ameliorates muscular dystrophy phenotype by developmentally increased vasculature in mdx mice
    Mayank Verma
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Hum Mol Genet 19:4145-59. 2010
    ..These data suggest that increasing the vasculature in DMD may ameliorate the histological and functional phenotypes associated with this disease...
  13. ncbi Requirement of the paraxis gene for somite formation and musculoskeletal patterning
    R Burgess
    Lexicon Genetics Inc, The Woodlands, Texas 77381, USA
    Nature 384:570-3. 1996
    ..These results demonstrate that paraxis regulates somite morphogenesis, and that the function of somites is to pattern the axial skeleton and skeletal muscles...
  14. ncbi Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
    Lina Kassar-Duchossoy
    Stem Cells and Development, Department of Developmental Biology, CNRS URA 2578, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nature 431:466-71. 2004
    ..Two determination factors of the basic helix-loop-helix myogenic regulatory factor (MRF) family, Myf5 and Myod, are thought to direct this transition because double-mutant mice totally lack skeletal muscle fibres and ..
  15. ncbi Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome
    A Patapoutian
    Division of Biology 156 29, California Institute of Technology, Pasadena 91125, USA
    Development 121:3347-58. 1995
    ..Finally, a later and relatively mild phenotype was detected in intercostal muscles of newborn animals...
  16. ncbi The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts
    Bryan P Haines
    Section of Gene Function and Regulation, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Dev Biol 281:145-59. 2005
    ..the earliest myoblasts that originate from the dorsal lip in a pattern reminiscent of the muscle determination gene Myf5, but not at the ventral lip, indicating that NLRR-1 is expressed in a subset of myotome cells...
  17. pmc Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints
    Ingeborg Teppner
    GSF National Research Center for Environment and Health, GmbH, Institute of Experimental Genetics, Neuherberg, Germany
    BMC Dev Biol 7:68. 2007
    ..We did this by overexpressing a functional copy of the Dll1 gene throughout the paraxial mesoderm, in particular in anterior somite compartments, during somitogenesis in transgenic mice...
  18. doi The regulatory mechanisms that underlie inappropriate transcription of the myogenic determination gene Myf5 in the central nervous system
    Philippe Daubas
    Institut Pasteur, CNRS URA 2578, Department of Developmental Biology, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Biol 327:71-82. 2009
    b>Myf5 is a key myogenic determination factor, specifically present at sites of myogenesis...
  19. ncbi Maintenance of somite borders in mice requires the Delta homologue DII1
    M Hrabe de Angelis
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nature 386:717-21. 1997
    ....
  20. ncbi Persistent expression of MNF identifies myogenic stem cells in postnatal muscles
    D J Garry
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75235, USA
    Dev Biol 188:280-94. 1997
    ..These data identify MNF as a marker of quiescent satellite cells and suggest that downstream genes controlled by MNF serve to modulate proliferative growth or differentiation in this unique cell population...
  21. ncbi The early epaxial enhancer is essential for the initial expression of the skeletal muscle determination gene Myf5 but not for subsequent, multiple phases of somitic myogenesis
    Lydia Teboul
    Division of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 129:4571-80. 2002
    Vertebrate myogenesis is controlled by four transcription factors known as the myogenic regulatory factors (MRFs): Myf5, Mrf4, myogenin and MyoD...
  22. pmc Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis
    Malay Haldar
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112, USA
    Dev Cell 14:437-45. 2008
    In skeletal muscle development, the myogenic regulatory factors myf5 and myoD play redundant roles in the specification and maintenance of myoblasts, whereas myf6 has a downstream role in differentiating myocytes and myofibers...
  23. pmc Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program
    Mounia Lagha
    CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 75015 Paris, France
    Genes Dev 22:1828-37. 2008
    ..These results provide new insight into the Pax-initiated regulatory network that modulates stem cell maintenance versus tissue differentiation...
  24. ncbi Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development
    M A Rudnicki
    Whitehead Institute, Massachusetts Institute of Technology, Cambridge 02142
    Cell 71:383-90. 1992
    ..Our results indicate that MyoD is dispensable for skeletal muscle development in mice, revealing some degree of functional redundancy in the control of the skeletal myogenic developmental program...
  25. ncbi Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death
    T Braun
    Department of Toxicology, University of Hamburg Medical School, Germany
    Cell 71:369-82. 1992
    ....
  26. ncbi The myoD gene family: nodal point during specification of the muscle cell lineage
    H Weintraub
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Science 251:761-6. 1991
    ..MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis...
  27. pmc The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development
    E Bober
    Department of Toxicology, Medical School, University of Hamburg, Germany
    J Cell Biol 113:1255-65. 1991
    ..The reappearance of Myf-6 mRNA in fetal skeletal muscle coincides approximately with secondary muscle fiber formation and the onset of innervation...
  28. pmc A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts
    T Braun
    University of Hamburg Medical School, Department of Toxicology, FRG
    EMBO J 8:701-9. 1989
    ..Two additional short segments with high serine and threonine content are conserved between the two proteins.(ABSTRACT TRUNCATED AT 250 WORDS)..
  29. pmc Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm development
    M A Blanar
    Hormone Research Institute, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 92:5870-4. 1995
    ..Our findings suggest that Meso1 may be a key regulatory gene involved in the early events of vertebrate mesoderm differentiation...
  30. ncbi Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies
    W Zhang
    Department of Biochemistry, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 9:1388-99. 1995
    The myogenic basic helix-loop-helix (bHLH) proteins MyoD, myf5, myogenin, and MRF4 can initiate myogenesis when expressed in nonmuscle cells...
  31. ncbi The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
    R Kopan
    Fred Hutchinson Cancer Research Center, Howard Hughes Medical Institute, Seattle, WA 98104
    Development 120:2385-96. 1994
    ..Additional experiments show that the CDC10/SWI6/ankyrin repeats are also necessary for myogenic inhibition...
  32. ncbi Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells
    E Bober
    Department of Cell and Molecular Biology, Technical University of Braunschweig, Germany
    Development 120:603-12. 1994
    ..These observations suggest that Pax-3 is necessary for the formation of limb muscles, affecting either the generation of myogenic precursors in the somitic dermomyotome or the migration of these cells into the limb field...
  33. pmc Mouse limb muscle is determined in the absence of the earliest myogenic factor myf-5
    S Tajbakhsh
    Department of Molecular Biology, Centre National de la Recherche Scientifique, URE 67, Pasteur Institute, Paris, France
    Proc Natl Acad Sci U S A 91:747-51. 1994
    ..Furthermore, myogenic precursor cells in the somite, which, according to the avian model, migrate from the ventral/lateral edge of the dermomyotome to form peripheral muscle masses, are also negative for these factors...
  34. pmc Myf-5 and myoD genes are activated in distinct mesenchymal stem cells and determine different skeletal muscle cell lineages
    T Braun
    Department of CCell and Molecular Biology, University of Braunschweig, Germany
    EMBO J 15:310-18. 1996
    ..Thus skeletal musculature in vertebrates develops from two separate cell lineages and complementation may occur at the cellular level, but not between different myogenic factor genes within one cell...
  35. ncbi Gene targeting the myf-5 locus with nlacZ reveals expression of this myogenic factor in mature skeletal muscle fibres as well as early embryonic muscle
    S Tajbakhsh
    Department of Molecular Biology, CNRS URA1947, Pasteur Institute, Paris, France
    Dev Dyn 206:291-300. 1996
    ..These results suggest that the myf-5 gene is not activated in only a subset of muscle cells and are consistent with the results on the MyoD knockout mice...
  36. ncbi Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice
    S Tajbakhsh
    Unité de Génétique Moléculaire du Développement, CNRS URA1947, Paris, France
    Nature 384:266-70. 1996
    ..In its absence, muscle progenitors, having activated myf-5, remain multipotent and differentiate into other somitic derivatives according to their local environment...
  37. ncbi Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD
    S Tajbakhsh
    Department of Molecular Biology, Centre National de la Recherche Scientifique, Unité de Recherche Associe 1947, Pasteur Institute, Paris, France
    Cell 89:127-38. 1997
    ..Therefore, Pax-3 and Myf-5 define two distinct myogenic pathways, and MyoD acts genetically downstream of these genes for myogenesis in the body. This genetic hierarchy does not appear to operate for head muscle formation...
  38. ncbi Myogenic determination occurs independently in somites and limb buds
    B Kablar
    Institute for Molecular Biology and Biotechnology, Cancer Research Group, McMaster University, Hamilton, Ontario, L8S 4K1, Canada
    Dev Biol 206:219-31. 1999
    ..Therefore, cells are recruited into the MyoD-dependent myogenic lineage through activation of the -20-kb MyoD enhancer and this occurs independently in somites and limb buds...
  39. pmc Reduced differentiation potential of primary MyoD-/- myogenic cells derived from adult skeletal muscle
    L A Sabourin
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Cell Biol 144:631-43. 1999
    ..We interpret these data to suggest that MyoD-/- myogenic cells represent an intermediate stage between a quiescent satellite cell and a myogenic precursor cell...
  40. ncbi Rib truncations and fusions in the Sp2H mouse reveal a role for Pax3 in specification of the ventro-lateral and posterior parts of the somite
    D J Henderson
    Neural Development Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, United Kingdom
    Dev Biol 209:143-58. 1999
    ..of gene expression markers of lateral sclerotome (tenascin-C and scleraxis) and myotome (myogenin, MyoD, and Myf5)...
  41. ncbi Sonic hedgehog controls epaxial muscle determination through Myf5 activation
    A G Borycki
    Department of Cell Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Development 126:4053-63. 1999
    ..during somite myogenesis in the mouse embryo, we have analyzed the expression of the myogenic determination genes, Myf5 and MyoD, and other regulatory genes in somites of Shh null embryos and in explants of presomitic mesoderm from ..
  42. ncbi Early development of the myotome in the mouse
    S J Venters
    Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    Dev Dyn 216:219-32. 1999
    ..Furthermore, early myotomal myocytes differentiate in the absence of MyoD expression, unlike later myotomal myocytes. This, along with their distinct morphology, suggests these cells may form a separate lineage of pioneer myogenic cells...
  43. ncbi Genetics of muscle determination and development
    H H Arnold
    Department of Cell and Molecular Biology, Technical University of Braunschweig, Germany
    Curr Top Dev Biol 48:129-64. 2000
    ..Finally, we present recent evidence on genes that play a role in regeneration of muscle in adult organisms...
  44. ncbi A new look at the origin, function, and "stem-cell" status of muscle satellite cells
    P Seale
    Department of Biology, Institute for Molecular Biology and Biotechnology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
    Dev Biol 218:115-24. 2000
    ..Manipulation of such tissue-specific stem cells may eventually revolutionize therapies for degenerative diseases, including muscular dystrophy...
  45. ncbi Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4
    M R Valdez
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas, 75235 9148, USA
    Dev Biol 219:287-98. 2000
    The basic helix-loop-helix (bHLH) transcription factors-MyoD, Myf5, myogenin, and MRF4-can each activate the skeletal muscle-differentiation program in transfection assays...
  46. ncbi Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent
    B Kablar
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Development 127:1627-39. 2000
    ..Moreover, transdifferentiation was markedly delayed or absent only in the absence of Myf5, suggesting that appropriate initiation and progression of smooth-to-skeletal muscle transdifferentiation is Myf5-..
  47. ncbi The molecular regulation of myogenesis
    L A Sabourin
    Institute for Molecular Biology and Biotechnology, MOBIX, McMaster University, Hamilton, Ontario, Canada
    Clin Genet 57:16-25. 2000
    ..This has put forward the hypothesis that these factors also play specific biological roles following muscle injury and repair...
  48. ncbi Thoracic skeletal defects in myogenin- and MRF4-deficient mice correlate with early defects in myotome and intercostal musculature
    J L Vivian
    Department of Biochemistry and Molecular Biology and Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, Texas 77050, USA
    Dev Biol 224:29-41. 2000
    ..combinations displayed ventral myotome defects, including a failure to express normal levels of myf5. The results suggested that the early muscle defects observed in myogenin and MRF4 mutants may cause subsequent ..
  49. ncbi A BAC transgenic analysis of the Mrf4/Myf5 locus reveals interdigitated elements that control activation and maintenance of gene expression during muscle development
    J J Carvajal
    Division of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 128:1857-68. 2001
    The muscle-specific transcription factors Myf5 and Mrf4 are two of the four myogenic regulatory factors involved in the transcriptional cascade responsible for skeletal myogenesis in the vertebrate embryo...
  50. ncbi Expression of the myogenic regulatory factor Mrf4 precedes or is contemporaneous with that of Myf5 in the somitic bud
    Dennis Summerbell
    Division of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Mech Dev 117:331-5. 2002
    ..In the somites of the mouse embryo the order of expression is thought to be Myf5, Myogenin, Mrf4 and MyoD...
  51. ncbi Control of facial muscle development by MyoR and capsulin
    Jian Rong Lu
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Science 298:2378-81. 2002
    ..These findings identify MyoR and capsulin as unique transcription factors for the development of specific head muscles...
  52. pmc VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation
    Stefan Günther
    Institute of Physiological Chemistry, University of Halle Wittenberg, Hollystrasse 1, 06097 Halle, Germany
    Nucleic Acids Res 32:791-802. 2004
    ..We conclude that VITO-1 is a crucial new cofactor of the muscle regulatory programme...
  53. ncbi Myf5 expression in satellite cells and spindles in adult muscle is controlled by separate genetic elements
    Peter S Zammit
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, W12 0NN, UK
    Dev Biol 273:454-65. 2004
    The myogenic regulatory factor Myf5 is integral to the initiation and control of skeletal muscle formation...
  54. pmc Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation
    Michael S Huh
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada, K1H 8L6
    J Cell Biol 166:865-76. 2004
    ..b>Myf5-Cre mice, lacking pRb in myoblasts, died immediately at birth and exhibited high numbers of apoptotic nuclei and an ..
  55. ncbi The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis
    Robert G Kelly
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Hum Mol Genet 13:2829-40. 2004
    ..In the absence of Tbx1, the myogenic determination genes Myf5 and MyoD fail to be normally activated in pharyngeal mesoderm...
  56. ncbi Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo
    Raphaelle Grifone
    Departement Genetique, Developpement et Pathologie Moleculaire, Institut Cochin INSERM 567, CNRS UMR 8104, Universite Paris V, 24 Rue du Faubourg Saint Jacques 75014 Paris, France
    Development 132:2235-49. 2005
    ..b>Myf5 expression is correctly initiated but becomes restricted to the caudal region of each somite...
  57. pmc Pax3/Pax7 mark a novel population of primitive myogenic cells during development
    Lina Kassar-Duchossoy
    Department of Developmental Biology, Pasteur Institute, Centre Nationale de la Recherche Scientifique Unité de Recherche Associeé 2578, 75724 Paris, Cedex 15, France
    Genes Dev 19:1426-31. 2005
    ..These findings identify critical cell populations during lineage restriction, and provide a framework for defining myogenic cell states for therapeutic studies...
  58. pmc MyoD induces myogenic differentiation through cooperation of its NH2- and COOH-terminal regions
    Jeff Ishibashi
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    J Cell Biol 171:471-82. 2005
    MyoD and Myf5 are basic helix-loop-helix transcription factors that play key but redundant roles in specifying myogenic progenitors during embryogenesis...
  59. ncbi Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning
    Kwang Won Seo
    Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, 77030, USA
    Dev Biol 290:200-10. 2006
    ..alterations in the expression patterns of dermomyotomal and myotomal transcription factors including Pax3, Paraxis, Myf5, myogenin, Mrf4 and MyoD. Despite these defects, embryos harvested from E13...
  60. ncbi Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo
    Fernanda Bajanca
    Department of Animal Biology and Centre for Environmental Biology, Faculty of Sciences, University of Lisbon, 1749 016 Lisbon, Portugal
    Development 133:1635-44. 2006
    ..Assembly of the myotomal laminin matrix occurs as epaxial myogenic precursor cells enter the myotome. Most Myf5-positive and myogenin-negative myogenic precursor cells localise near assembled laminin, while myogenin-expressing ..
  61. ncbi MyoD, Myf5, and the calcineurin pathway activate the developmental myosin heavy chain genes
    Doris Heidysch Beylkin
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Dev Biol 294:541-53. 2006
    ..Some common features are shared between the promoters of these two genes; however, the mechanisms of their regulation appear distinct...
  62. ncbi The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis
    Ugo Borello
    Stem Cell Research Institute, DIBIT, H San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Development 133:3723-32. 2006
    Canonical Wnt/beta-catenin signaling regulates the activation of the myogenic determination gene Myf5 at the onset of myogenesis, but the underlying molecular mechanism is unknown...
  63. pmc A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb
    Lola Bajard
    Centre National de la Recherche Scientifique URA 2578, Department of Developmental Biology, Pasteur Institute, 75015 Paris, France
    Genes Dev 20:2450-64. 2006
    ..At these sites, expression of Myf5 is compromised, showing that Pax3 acts genetically upstream of this myogenic determination gene...
  64. ncbi Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo
    Raphaelle Grifone
    département génétique et développement, Institut Cochin Paris, INSERM, U567, Paris, F 75014 France
    Dev Biol 302:602-16. 2007
    ..These results establish a new hierarchy of genes controlling early steps of hypaxial myogenic commitment in the mouse embryo...
  65. ncbi Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle
    Feiyan Dong
    Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, TX 77030, USA
    Development 133:4891-9. 2006
    ..Conditional inactivation in mice and manipulation of Pitx2 expression in chick mandible cultures revealed an autonomous function in expansion and survival of branchial arch mesoderm...
  66. pmc Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants
    Karin Schuster-Gossler
    Institute for Molecular Biology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, D 30625 Lower Saxony, Germany
    Proc Natl Acad Sci U S A 104:537-42. 2007
    ....
  67. ncbi Intrinsic phenotypic diversity of embryonic and fetal myoblasts is revealed by genome-wide gene expression analysis on purified cells
    Stefano Biressi
    Stem Cell Research Institute, DIBIT, H San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Dev Biol 304:633-51. 2007
    ..Using a mouse strain with the GFP reporter gene targeted into the Myf5 locus, a cell-sorting method was developed for isolating embryonic and fetal myoblasts...
  68. pmc Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch
    Hung Ping Shih
    Department of Pharmaceutical Sciences, College of Pharmacy, College of Sciences, Oregon State University, Corvallis, OR 97331, USA
    Proc Natl Acad Sci U S A 104:5907-12. 2007
    ..5. The diminutive first branchial arch of mutants could not be explained by loss of mesoderm alone, suggesting that Pitx2 contributes to the earliest specification of jaw itself...
  69. ncbi The myogenic factor Myf5 supports efficient skeletal muscle regeneration by enabling transient myoblast amplification
    Svetlana Ustanina
    Max Planck Institute for Heart and Lung Research, Department of Cardiac Development and Remodeling, Parkstrasse 1, Bad Nauheim, Germany
    Stem Cells 25:2006-16. 2007
    The myogenic factor Myf5 defines the onset of myogenesis in mammals during development. Mice lacking both Myf5 and MyoD fail to form myoblasts and are characterized by a complete absence of skeletal muscle at birth...
  70. ncbi The dual effects of Cdh1/APC in myogenesis
    Wenqi Li
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    FASEB J 21:3606-17. 2007
    ..myogenic differentiation through regulating cell cycle progression and modulating myogenic factors such as MyoD and Myf5. Certain ubiquitin protein ligases, including the SCF complex and APC, have been suggested to govern terminal ..
  71. ncbi Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis
    Ariel Rinon
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Development 134:3065-75. 2007
    ..We suggest that CNC cells control craniofacial development by regulating positional interactions with mesoderm-derived muscle progenitors that together shape the cranial musculoskeletal architecture in vertebrate embryos...
  72. ncbi A role for the myogenic determination gene Myf5 in adult regenerative myogenesis
    Barbara Gayraud-Morel
    Stem Cells and Development, Dept of Developmental Biology, Pasteur Institute, CNRS URA 2578, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Biol 312:13-28. 2007
    The myogenic determination genes Myf5, Myod and Mrf4 direct skeletal muscle cell fate prenatally...
  73. pmc Global transcriptional regulation of the locus encoding the skeletal muscle determination genes Mrf4 and Myf5
    Jaime J Carvajal
    Section of Gene Function and Regulation, The Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom
    Genes Dev 22:265-76. 2008
    The linked Mrf4 and Myf5 genes encode two transcription factors essential for the determination and differentiation of skeletal muscle in the embryo...
  74. doi Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis
    Nicole Gensch
    Max Planck Institute for Heart and Lung Research, Parkstr 1, 61231 Bad Nauheim, Germany
    Development 135:1597-604. 2008
    The development of myogenic cells is mainly determined by expression of two myogenic factors, Myf5 and Myod1 (MyoD), which genetically compensate for each other during embryogenesis...
  75. doi VITO-2, a new SID domain protein, is expressed in the myogenic lineage during early mouse embryonic development
    Michal Mielcarek
    Max Planck Institute for Heart and Lung Research, Department of Cardiac Development and Remodelling, Parkstr 1, D 61231 Bad Nauheim, Hessen, Germany
    Gene Expr Patterns 9:129-37. 2009
    ..5 while Myf-5 mutant mice lack expression of VITO-1 and VITO-2 in somites until E10.5...
  76. pmc Functionally reduced sensorimotor connections form with normal specificity despite abnormal muscle spindle development: the role of spindle-derived neurotrophin 3
    Neil A Shneider
    Section on Developmental Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:4719-35. 2009
    ..These findings indicate that spindle-derived factors regulate the strength of the connections but not their initial formation or their specificity...
  77. pmc Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells
    Fabien Le Grand
    Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Regenerative Medicine Program, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
    Cell Stem Cell 4:535-47. 2009
    ..Therefore, Wnt7a signaling through the planar cell polarity pathway controls the homeostatic level of satellite stem cells and hence regulates the regenerative potential of muscle...
  78. doi Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates
    Ramkumar Sambasivan
    Institut Pasteur, Stem Cells and Development, CNRS URA 2578, Universite de la Mediterranee, Campus de Luminy, Marseille, France
    Dev Cell 16:810-21. 2009
    ..We show that either Myf5 or Mrf4 is necessary for initiating extraocular myogenesis...
  79. pmc TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis
    Ryoichi Hosokawa
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    Dev Biol 341:186-95. 2010
    ..The addition of FGF10 rescued the muscle cell number in Wnt1-Cre;Tgfbr2(flox/flox) mice. Thus, TGF-beta induced FGF10 signaling has a critical function in regulating tissue-tissue interaction during tongue skeletal muscle development...
  80. pmc A Pax3/Dmrt2/Myf5 regulatory cascade functions at the onset of myogenesis
    Takahiko Sato
    Department of Developmental Biology, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Institut Pasteur, Paris, France
    PLoS Genet 6:e1000897. 2010
    ..This depends on activation, in the epaxial dermomyotome, of the myogenic determination gene, Myf5, through its early epaxial enhancer...
  81. doi Evidence for a myotomal Hox/Myf cascade governing nonautonomous control of rib specification within global vertebral domains
    Tânia Vinagre
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Dev Cell 18:655-61. 2010
    ..rib-containing and rib-less areas is first interpreted in the myotome through the regional-specific control of Myf5 and Myf6 expression...
  82. pmc Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo
    Mounia Lagha
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 rue du Dr Roux, Paris, France
    BMC Genomics 11:696. 2010
    ..Few Pax3 target genes have been identified. Identifying genes that lie genetically downstream of Pax3 is therefore an important endeavour in elucidating the myogenic gene regulatory network...
  83. pmc A TGFβ-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development
    Dong Han
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Development 139:1640-50. 2012
    ..myogenic progenitors during tongue morphogenesis through tissue-specific inactivation of Smad4 (using Myf5-Cre;Smad4(flox/flox) mice)...
  84. ncbi MyoD and Myf-5 differentially regulate the development of limb versus trunk skeletal muscle
    B Kablar
    Institute for Molecular Biology and Biotechnology, Cancer Research Group, McMaster University, Hamilton, Ontario, Canada
    Development 124:4729-38. 1997
    ..Taken together, these observations strongly support the hypothesis that Myf-5 and MyoD play unique roles in the development of epaxial and hypaxial muscle, respectively...
  85. ncbi Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice
    A Rawls
    Department of Molecular Biology and Oncology, Department of Pathology, UT Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Development 125:2349-58. 1998
    The myogenic basic helix-loop-helix (bHLH) genes - MyoD, Myf5, myogenin and MRF4 - exhibit distinct, but overlapping expression patterns during development of the skeletal muscle lineage and loss-of-function mutations in these genes ..
  86. ncbi Modular long-range regulation of Myf5 reveals unexpected heterogeneity between skeletal muscles in the mouse embryo
    J Hadchouel
    Departement de Biologie Moleculaire, CNRS URA 1947, Institut Pasteur, 75724 Paris Cedex 15, France
    Development 127:4455-67. 2000
    The myogenic factor Myf5 plays a key role in muscle cell determination, in response to signalling cascades that lead to the specification of muscle progenitor cells...
  87. ncbi Temporal and quantitative analysis of myogenic regulatory and growth factor gene expression in the developing mouse embryo
    K Hannon
    Department of Biotechnology Research, Lilly Research Laboratories, Indianapolis, Indiana 46285
    Dev Biol 151:137-44. 1992
    ..chain reaction method, the temporal pattern of expression of the myogenic regulatory genes (myf5, myogenin, MRF4, myo D) was quantitated in developing mouse muscle (whole embryo: 6.5 to 12...
  88. ncbi Activation of the gene encoding the glycolytic enzyme beta-enolase during early myogenesis precedes an increased expression during fetal muscle development
    A Keller
    Laboratoire de Biochimie Cellulaire, CNRS URA 1115, College de France, Paris
    Mech Dev 38:41-54. 1992
    ..The regulation of this muscle-specific gene in somites is discussed in terms of the myogenic sequences of the MyoD family shown to be present when it is activated...
  89. pmc The MyoD family of myogenic factors is regulated by electrical activity: isolation and characterization of a mouse Myf-5 cDNA
    A Buonanno
    Unit on Molecular Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Nucleic Acids Res 20:539-44. 1992
    ..Using extracellular electrodes to directly stimulate in situ the soleus muscle of rats, we found that 'electrical activity' per se, in absence of the nerve, represses the increases of myogenic factor mRNAs associated with denervation...
  90. ncbi Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation
    M C Bidwell
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 136:5189-201. 1995
    ....
  91. ncbi Cloning and expression analysis of a novel mesodermally expressed cadherin
    I Hoffmann
    Institut fur Saugetiergenetik, GSF Forschungszentrum Neuherberg, Oberschleissheim, Federal Republic of Germany
    Dev Biol 169:337-46. 1995
    ....
  92. ncbi Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis
    M Ito
    Institute for Genetic Medicine, University of Southern California School of Medicine, Los Angeles 90033
    Dev Biol 167:317-28. 1995
    ....
  93. ncbi Detection of messenger RNA by in situ hybridization
    D Sassoon
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118
    Methods Enzymol 225:384-404. 1993
  94. ncbi Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6
    S Grass
    Department of Cell and Molecular Biology, University of Braunschweig, Germany
    Development 122:141-50. 1996
    ....
  95. ncbi Expression of M-twist during postimplantation development of the mouse
    E M Füchtbauer
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Dev Dyn 204:316-22. 1995
    ..However, during organogenesis, M-twist is expressed in several areas of mesenchyme-epithelia interactions, suggesting additional tissue specific functions...
  96. ncbi Cardiomyopathy in transgenic myf5 mice
    J G Edwards
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
    Circ Res 78:379-87. 1996
    ..Myocardial bmyf5 expression therefore induces a program of skeletal muscle gene expression that results in progressive cardiomyopathy that may be due to incompatibility of heart and skeletal muscle structural proteins...
  97. ncbi Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice
    L Tiret
    Unité d Embryologie Moléculaire, Institut Pasteur, URA 1947 du CNRS, Paris, France
    Development 125:279-91. 1998
    ..In Hoxc-8 null mutants, C(7-8) motoneurons lose their selective advantage in growth cone pathfinding behavior and/or target recognition, two essential steps in the establishment and maintenance of a functional nervous system...
  98. ncbi Paradox segmentation along inter- and intrasomitic borderlines is followed by dysmorphology of the axial skeleton in the open brain (opb) mouse mutant
    R Spörle
    Institute of Mammalian Genetics ISG, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Dev Genet 22:359-73. 1998
    ..The segmentation defects observed suggest that in opb mutants both segmental borderlines, the somite borders and the intrasomitic borderlines (fissures), were affected and behaved paradoxically...
  99. pmc MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis
    B D Yu
    Howard Hughes Medical Institute, Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 95:10632-6. 1998
    ..Thus, Mll represents an essential mechanism of transcriptional maintenance in mammalian development, which functions in multiple morphogenetic processes...
  100. ncbi Transcriptional mechanisms regulating MyoD expression in the mouse
    J C Chen
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 219 Anatomy Chemistry Building, 36th and Hamilton Walk, Philadelphia, PA 19104 6058, PA 19104, USA
    Cell Tissue Res 296:213-9. 1999
    ..Here we discuss recent advances in these areas, with emphasis on in vivo analyses of MyoD transcription...
  101. ncbi Expression of the Nkx3.1 homobox gene during pre and postnatal development
    M Tanaka
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Mech Dev 85:179-82. 1999
    ..5 p.c. In later stage embryos and neonates, Nkx3.1 was expressed in subpopulations of epithelial cells, particularly in epithelial outgrowths. Nkx3.1 was also expressed in restricted regions of the central nervous system...

Research Grants1

  1. Molecular Mechanisms Regulating Stem Cell Plasticity
    Michael Rudnicki; Fiscal Year: 2004
    ..To investigate the mechanism by which Pax7 enforces lineage commitment, FACS/Hoechst enriched adult stem cells from Pax7-/- mice will be transplanted either intravenously or intramuscularly. ..