Mylpf

Summary

Gene Symbol: Mylpf
Description: myosin light chain, phosphorylatable, fast skeletal muscle
Alias: 2410014J02Rik, MLC-2, Mlc2, myosin regulatory light chain 2, skeletal muscle isoform, MLC2F, fast skeletal myosin light chain 2, myosin light chain 2
Species: mouse

Top Publications

  1. doi Deletion of Mylk1 in oocytes causes delayed morula-to-blastocyst transition and reduced fertility without affecting folliculogenesis and oocyte maturation in mice
    Qiu Xia Liang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China
    Biol Reprod 92:97. 2015
  2. doi The FgfrL1 receptor is required for development of slow muscle fibers
    Ruth Amann
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    Dev Biol 394:228-41. 2014
  3. doi Overexpression of Six1 gene suppresses proliferation and enhances expression of fast-type muscle genes in C2C12 myoblasts
    Wangjun Wu
    Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
    Mol Cell Biochem 380:23-32. 2013
  4. pmc During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation
    Shenhav Cohen
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 185:1083-95. 2009
  5. pmc Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis
    Chang Jin
    Department of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Avenue, Kettering Laboratory, Suite 410, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Dev Biol 374:96-107. 2013
  6. ncbi Non conservation of function for the evolutionarily conserved prdm1 protein in the control of the slow twitch myogenic program in the mouse embryo
    Stephane D Vincent
    Department of Developmental Biology, CNRS URA 2575, Institut Pasteur, Paris, France
    Mol Biol Evol 29:3181-91. 2012
  7. pmc Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    BMC Dev Biol 7:128. 2007
  8. pmc MDR1 function is sensitive to the phosphorylation state of myosin regulatory light chain
    Gaurav Bajaj
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    Biochem Biophys Res Commun 398:7-12. 2010
  9. doi Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome
    Claire Niro
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Dev Biol 338:168-82. 2010
  10. ncbi The fast skeletal muscle myosin light chain is differentially expressed in smooth muscle cells of OVA-challenged mouse trachea
    Ho Young Kim
    Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University Hospital, Bucheon 420 767, Korea
    Mol Cells 25:78-85. 2008

Scientific Experts

  • Wangjun Wu
  • Stephane D Vincent
  • Huiping Zhu
  • Qiu Xia Liang
  • Ruth Amann
  • Chang Jin
  • Gaurav Bajaj
  • Claire Niro
  • Shenhav Cohen
  • Ho Young Kim
  • Yingcai Wang
  • Yasuhiro Kazuki
  • Shu Tao Qi
  • Heide Schatten
  • Meng Wen Hu
  • Xue Shan Ma
  • Zhong Wei Wang
  • Min Sheng Zhu
  • Zhen Bo Wang
  • Qing Hua Zhang
  • Qing Yuan Sun
  • Stefan Wyder
  • Beat Trueb
  • Anne M Slavotinek
  • Ying Xia
  • Qinghang Meng
  • Esmond Geh
  • Neville N C Tam
  • Saikumar Karyala
  • Shuk Mei Ho
  • Mario Medvedovic
  • Vinicius Carreira
  • Jing Chen
  • Xiangtian Zhou
  • Nicolas Sgarioto
  • Alexandre Blais
  • Julien Giordani
  • Ying Fan
  • Isabelle Guillet-Deniau
  • Maryline Favier
  • Yubing Liu
  • Josiane Demignon
  • Rosita Rodriguez-Proteau
  • Anand Venkataraman
  • Jane E Ishmael
  • Pascal Maire
  • Chrissa Kioussi
  • Alfred L Goldberg
  • David J Glass
  • Jeffrey J Brault
  • Steven P Gygi
  • Esther Latres
  • Carlos Gartner
  • David M Valenzuela
  • Pyoung Oh Yoon
  • Soo Ho Kim
  • Mi Hyun Ahn
  • Taiyoun Rhim
  • Choon Sik Park
  • Sang Han Lee
  • Georgianna Guzman
  • Zoraida Diaz-Perez
  • Danuta Szczesna-Cordary
  • Todd Miller
  • Roger Craig
  • James D Potter
  • Ryuichi Nishigaki
  • Mitsuo Oshimura
  • Yoshiteru Kai
  • Kazunori Hanaoka
  • Toshiaki Inoue
  • Satoshi Abe
  • Motoshi Kimura
  • Yasuaki Shirayoshi
  • Chiga Okita
  • Thomas C Schulz
  • Kazuma Tomizuka
  • N E Block
  • J Palermo
  • A Faerman
  • J A Dominov
  • Z Zhu
  • J B Miller
  • A M Kachinsky
  • J Gulick
  • M Shani
  • W Ng
  • J Robbins
  • G Grupp
  • I L Grupp

Detail Information

Publications19

  1. doi Deletion of Mylk1 in oocytes causes delayed morula-to-blastocyst transition and reduced fertility without affecting folliculogenesis and oocyte maturation in mice
    Qiu Xia Liang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China
    Biol Reprod 92:97. 2015
    ..Our findings provide evidence that MLCK is linked to timely blastocyst formation, though it is dispensable for oocyte meiotic maturation. ..
  2. doi The FgfrL1 receptor is required for development of slow muscle fibers
    Ruth Amann
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    Dev Biol 394:228-41. 2014
    ..fibers, fast fibers do not appear to be affected as shown by expression of fast fiber markers Myh3, Myh8, Myl1 and MylPF. At early developmental stages (E10.5, E15.5), FgfrL1-deficient animals express slow fiber genes at normal levels...
  3. doi Overexpression of Six1 gene suppresses proliferation and enhances expression of fast-type muscle genes in C2C12 myoblasts
    Wangjun Wu
    Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
    Mol Cell Biochem 380:23-32. 2013
    ..that Six1 overexpression could significantly promote the expression of fast-type muscle genes Atp2a1, Srl, and Mylpf. Furthermore, Six1 overexpressing C2C12 cells displayed a relative lower proliferative potential, and cell cycle ..
  4. pmc During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation
    Shenhav Cohen
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 185:1083-95. 2009
    ..Because these proteins stabilize the thick filament, their selective ubiquitylation may facilitate thick filament disassembly. However, the thin filament components decreased by a mechanism not requiring MuRF1...
  5. pmc Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis
    Chang Jin
    Department of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Avenue, Kettering Laboratory, Suite 410, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Dev Biol 374:96-107. 2013
    ..Using LCM and expression array, our studies have uncovered novel molecular signatures of MAP3K1 in embryonic eyelid closure...
  6. ncbi Non conservation of function for the evolutionarily conserved prdm1 protein in the control of the slow twitch myogenic program in the mouse embryo
    Stephane D Vincent
    Department of Developmental Biology, CNRS URA 2575, Institut Pasteur, Paris, France
    Mol Biol Evol 29:3181-91. 2012
    ....
  7. pmc Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    BMC Dev Biol 7:128. 2007
    ..Defective function of the Folr1 (also known as Folbp1; homologue of human FRalpha) gene in mice results in inadequate transport, accumulation, or metabolism of folate during cardiovascular morphogenesis...
  8. pmc MDR1 function is sensitive to the phosphorylation state of myosin regulatory light chain
    Gaurav Bajaj
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    Biochem Biophys Res Commun 398:7-12. 2010
    ....
  9. doi Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome
    Claire Niro
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Dev Biol 338:168-82. 2010
    ..This in vivo wide transcriptomal analysis of the function of the master myogenic determinants, Six, identifies them as novel markers for the differential activation of a specific muscle program during mammalian somitic myogenesis...
  10. ncbi The fast skeletal muscle myosin light chain is differentially expressed in smooth muscle cells of OVA-challenged mouse trachea
    Ho Young Kim
    Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University Hospital, Bucheon 420 767, Korea
    Mol Cells 25:78-85. 2008
    ..The overexpression of skMLC in murine asthma may be associated with the changes of bronchial smooth muscle...
  11. ncbi Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene
    K J Lee
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla 92093
    J Biol Chem 267:15875-85. 1992
    ....
  12. ncbi Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development
    Yingcai Wang
    Department of Molecular and Cellular Pharmacology, University of Miami, Miller School of Medicine, 1600 NW 10 Ave, Miami, FL 33136, USA
    FASEB J 21:2205-14. 2007
    ..and developmental significance of the fast skeletal isoform of the RLC (RLC-f), the murine fast skeletal RLC gene (Mylpf) was disrupted by homologous recombination...
  13. ncbi Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice
    Yasuhiro Kazuki
    Department of Molecular and Cell Genetics, Graduate School of Medical Science, Tottori University, 86 Nishimachi, Yonago, Tottori 683 8503, Japan
    Biochem Biophys Res Commun 317:491-9. 2004
    ..Thus, this chromosome engineering technology is a useful tool for identification or mapping of genes that contribute to the DS phenotypes...
  14. ncbi Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice
    N E Block
    Neuromuscular Laboratory, Massachusetts General Hospital, Charlestown 02129, USA
    Dev Dyn 207:382-94. 1996
    ..MRF function, therefore, appears to be differentially regulated in dermatomal and myotomal cells...
  15. ncbi Remodeling the mammalian heart using transgenesis
    J Palermo
    Division of Molecular Cardiovascular Biology, Children s Hospital Research Foundation, Cincinnati, OH 45267, USA
    Cell Mol Biol Res 41:501-9. 1995
    ..we attempted to remodel the mouse myocardium by ectopically expressing a ventricular form of the myosin light chain 2 (MLC2v) in the atrium...
  16. ncbi The expression of the regulatory myosin light chain 2 gene during mouse embryogenesis
    A Faerman
    Institute of Animal Science, ARO, Volcani Center, Bet Dagan, Israel
    Development 118:919-29. 1993
    The fast skeletal muscle myosin light chain 2 (MLC2) gene is expressed specifically in skeletal muscles of newborn and adult mice, and has no detectable sequence homology with any of the other MLC genes including the slow cardiac MLC2 ..
  17. pmc Construction of recombinant plasmids containing rat muscle actin and myosin light chain DNA sequences
    D Katcoff
    Proc Natl Acad Sci U S A 77:960-4. 1980
    ..A fifth plasmid contains sequences complementary to mRNA coding for myosin light chain 2. DNA of this plasmid hybridizes specifically with RNA extracted from muscle and differentiated muscle ..
  18. pmc The genes coding for the muscle contractile proteins, myosin heavy chain, myosin light chain 2, and skeletal muscle actin are located on three different mouse chromosomes
    H Czosnek
    EMBO J 1:1299-305. 1982
    ..All detectable myosin heavy chain genes are located on chromosome 11. The gene for the myosin light chain 2 is located on chromosome 7...
  19. ncbi Chromosomal distribution of genes coding for fast twitch skeletal muscle myosin light chains
    H Czosnek
    Somat Cell Mol Genet 11:533-40. 1985
    ..muscle myosin light chains are encoded by a multigene family which comprises the gene coding for the myosin light chain 2 (Myl2f), and the gene coding for both myosin light chains 1 and 3 (Myl1f/Myl3f)...