Genomes and Genes
Gene Symbol: Nppa
Description: natriuretic peptide type A
Alias: ANP, Anf, Pnd, natriuretic peptides A, atrial natriuretic factor, atrial natriuretic peptide, natriuretic peptide precursor type A, prepronatriodilatin
Publications133 found, 100 shown here
- GATA4 transcription factor is required for ventral morphogenesis and heart tube formationC T Kuo
Department of Medicine, The University of Chicago, Illinois 60637, USA
Genes Dev 11:1048-60. 1997..However, they define a critical role for GATA4 in regulating the rostral-to-caudal and lateral-to-ventral folding of the embryo that is needed for normal cardiac morphogenesis...
- Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expressionJ Wang
Department of Molecular Medicine, Karolinska Institutet, L8 02, Karolinska Hospital, S 171 76 Stockholm, Sweden
Proc Natl Acad Sci U S A 98:4038-43. 2001..It would therefore be of interest to determine whether manipulation of respiratory chain function can be used to inhibit or enhance apoptosis in these conditions...
- Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertensionS W John
Department of Pathology, University of North Carolina, Chapel Hill 27599
Science 267:679-81. 1995To determine if defects in the atrial natriuretic peptide (ANP) system can cause hypertension, mice were generated with a disruption of the proANP gene...
- Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesisJ D Molkentin
Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
Genes Dev 11:1061-72. 1997..We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP...
- Chamber formation and morphogenesis in the developing mammalian heartV M Christoffels
Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105, The Netherlands
Dev Biol 223:266-78. 2000..We traced the spatial pattern of expression of genes encoding atrial natriuretic factor, sarcoplasmic reticulum calcium ATPase, Chisel, Irx5, Irx4, myosin light chain 2v, and beta-myosin heavy ..
- A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and diseaseB G Bruneau
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Cell 106:709-21. 2001..Surprisingly, Tbx5 haploinsufficiency also markedly decreased atrial natriuretic factor (ANF) and connexin 40 (cx40) transcription, implicating these as Tbx5 target genes and providing a ..
- Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3Vinciane Gaussin
Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 99:2878-83. 2002..Hence, ALK3 is essential, beyond just the egg cylinder stage, for myocyte-dependent functions and signals in cardiac organogenesis...
- Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formationPetra E M H Habets
Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Genes Dev 16:1234-46. 2002..The atrial natriuretic factor (ANF) gene is specifically expressed in this developing chamber myocardium and is one of the first ..
- The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide geneBijoy D Thattaliyath
Department of Physiology, Mail code 7756, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
J Mol Cell Cardiol 34:1335-44. 2002..transcriptional targets, we have determined that HAND2 regulates the transcription of the Atrial Naturetic Peptide (ANP) gene. Results show that ANP expression is reduced in HAND2 null mice...
- PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5Mrudula Ganga
Department of Biological Science, The University of Tulsa, Tulsa, Oklahoma 74104 3189, USA
J Biol Chem 278:22437-45. 2003..We report here that the atrial natriuretic factor (ANF) promoter is a target of PITX2...
- The serum response factor coactivator myocardin is required for vascular smooth muscle developmentShijie Li
Departments of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
Proc Natl Acad Sci U S A 100:9366-70. 2003..5 and show no evidence of vascular SMC differentiation. Myocardin is the only transcription factor known to be necessary and sufficient for vascular SMC differentiation...
- Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesisJun K Takeuchi
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara 630 0101, Japan
Development 130:5953-64. 2003..In such heart, left ventricle (LV)-specific ANF gene was induced...
- T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambersVincent M Christoffels
Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Dev Dyn 229:763-70. 2004..and protein expression in mouse hearts was found to be complementary to that of chamber myocardium-specific genes Nppa, Cx40, Cx43, and Chisel, and was conserved in human...
- BMP10 is essential for maintaining cardiac growth during murine cardiogenesisHanying Chen
Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Development 131:2219-31. 2004..This may provide an underlying mechanism for understanding the pathogenesis of both structural and functional congenital heart defects...
- Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heartKiyonori Togi
Department of Social Service, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
Mol Cell Biol 24:4627-35. 2004..Furthermore, expression of Hand1/eHAND in the whole ventricles altered the expression patterns of Chisel, ANF, and Hand2/dHAND but did not affect Tbx5 expression...
- The transcriptional repressor Tbx3 delineates the developing central conduction system of the heartWillem M H Hoogaars
Experimental and Molecular Cardiology Group, AMC, University of Amsterdam, Amsterdam, The Netherlands
Cardiovasc Res 62:489-99. 2004..We studied the developmental expression pattern and functional aspects of the T-box transcription factor Tbx3, a novel marker for the murine central conduction system (CCS)...
- Lineage and morphogenetic analysis of the cardiac valvesFrederik J de Lange
Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Circ Res 95:645-54. 2004..The tricuspid septal leaflet then delaminates from the muscular ventricular septum late in development...
- Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart developmentZachary Harrelson
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Development 131:5041-52. 2004....
- GATA4 is a dosage-sensitive regulator of cardiac morphogenesisWilliam T Pu
Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
Dev Biol 275:235-44. 2004..Surprisingly, expression levels of the putative GATA4 target genes ANF, BNP, MEF2C, Nkx2-5, cyclin D2, and BMP4 were unchanged in mutant hearts, suggesting that GATA4 is not a dose-..
- The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent mannerDavid G McFadden
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
Development 132:189-201. 2005..These findings demonstrate that Hand factors play pivotal and partially redundant roles in cardiac morphogenesis, cardiomyocyte differentiation and cardiac-specific transcription...
- T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesisChen Leng Cai
Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Development 132:2475-87. 2005....
- Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron developmentJun K Takeuchi
Cardiovascular Research, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
Development 132:2463-74. 2005..We conclude that Tbx20 is positioned at a critical node in transcription factor networks required for heart and motoneuron development where it dose-dependently regulates gene expression...
- Morphogenesis of the right ventricle requires myocardial expression of Gata4Elisabeth M Zeisberg
Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 115:1522-31. 2005..Our results demonstrate a general role of myocardial Gata4 in regulating cardiomyocyte proliferation and a specific, stage-dependent role in regulating the morphogenesis of the RV and the atrioventricular canal...
- Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterningLijiang Ma
Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
Development 132:5601-11. 2005..Our data indicate that Bmp2 has a crucial role in coordinating multiple aspects of AV canal morphogenesis...
- Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heartKazuko Koshiba-Takeuchi
Programs in Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Nat Genet 38:175-83. 2006..Thus, a positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes...
- Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activityChinmay M Trivedi
Department of Cell and Developmental Biology, 1156 Basic Research Building II, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
Nat Med 13:324-31. 2007....
- Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodelingInes Ribeiro
Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
PLoS ONE 2:e398. 2007..Cardiomyocytes in the future chamber myocardium acquire different cellular and physiological characteristics through activation of a chamber-specific genetic program, which is in part mediated by T-box genes...
- Transcription factor Tbx3 is required for the specification of the atrioventricular conduction systemMartijn L Bakker
Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
Circ Res 102:1340-9. 2008..5 and 15.5, ectopically expressed genes for connexin (Cx)43, atrial natriuretic factor (Nppa), Tbx18, and Tbx20 in the atrioventricular bundle and proximal bundle branches...
- Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardiumYi Hui Chen
Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center and Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
BMC Dev Biol 8:75. 2008....
- Alternative splicing of the guanylyl cyclase-A receptor modulates atrial natriuretic peptide signalingMichael Hartmann
Institute of Physiology, University of Wurzburg, D 97070 Wurzburg, Germany
J Biol Chem 283:28313-20. 2008Atrial (ANP) and B-type natriuretic peptides (BNP) modulate blood pressure and volume through the stimulation of cyclic GMP production by their guanylyl cyclase-A (GC-A) receptor...
- Tbx3 is required for outflow tract developmentKarim Mesbah
Developmental Biology Institute of Marseilles Luminy, France
Circ Res 103:743-50. 2008....
- microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heartNing Liu
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Genes Dev 22:3242-54. 2008....
- MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in miceThomas E Callis
Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA
J Clin Invest 119:2772-86. 2009..Together, our studies uncover what we believe are novel miRNA-dependent mechanisms that modulate cardiac hypertrophy and electrical conduction...
- Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardiumDonna Lai
Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool St, Darlinghurst 2010, Australia
Circ Res 107:715-27. 2010..In development, the membrane-tethered signaling ligand Neuregulin (Nrg)1, expressed in endocardium, is essential for ventricular morphogenesis. In adults, Nrg1 protects against heart failure and can induce cardiomyocytes to divide...
- GATA5 interacts with GATA4 and GATA6 in outflow tract developmentBrigitte Laforest
Laboratoire de développement et différentiation cardiaque, Programme de biologie moléculaire, Universite de Montreal, Montreal QC, Canada H3C 3J7
Dev Biol 358:368-78. 2011..The data identify GATA5 as a potential genetic modifier of congenital heart disease and provide insight for elucidating the genetic basis of an important class of human birth defects...
- Polycomb repressive complex 2 regulates normal development of the mouse heartAibin He
Department of Cardiology, Children s Hospital Boston, MA, USA
Circ Res 110:406-15. 2012..Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27, which establishes H3K27me3 repressive epigenetic marks that promote tissue-specific differentiation by silencing ectopic gene programs...
- Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasisPaul Delgado-Olguín
Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
Nat Genet 44:343-7. 2012..Our results suggest that epigenetic dysregulation in embryonic progenitor cells is a predisposing factor for adult disease and dysregulated stress responses...
- Localized expression of the atrial natriuretic factor gene during cardiac embryogenesisR Zeller
Department of Genetics, Harvard Medical School, Boston, Massachusetts
Genes Dev 1:693-8. 1987Expression of the gene encoding atrial natriuretic factor (ANF) during mouse cardiac embryogenesis was studied using in situ hybridization to histologic sections...
- The gene for Lap18, leukemia-associated phosphoprotein p18 (metablastin), maps to distal mouse chromosome 4B A Mock
Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
Mamm Genome 4:461-2. 1993
- Mouse Pop1 is required for muscle regeneration in adult skeletal muscleBirgit Andrée
Cell and Molecular Biology, Technical University Braunschweig, Braunschweig, Germany
Mol Cell Biol 22:1504-12. 2002..In homozygotes, persistence of LacZ expression and a retarded ability to regenerate skeletal muscle were apparent, suggesting that Pop1 plays a role in muscle regeneration...
- Overexpression of Polycomb-group gene rae28 in cardiomyocytes does not complement abnormal cardiac morphogenesis in mice lacking rae28 but causes dilated cardiomyopathyHideyuki Koga
Department of Developmental Biology and Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari, Osaka, Japan
Lab Invest 82:375-85. 2002..rae28-induced dilated cardiomyopathy may thus provide a clue for clarifying the direct role of PcG in the maintenance of cardiomyocytes...
- Neuronal nitric oxide synthase expression in the mouse vomeronasal organ during prenatal developmentCarlo Zancanaro
Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, Universita di Verona, Strada Le Grazie 8, 37134 Verona, Italy
Eur J Neurosci 16:659-64. 2002..No immunoreactivity for atrial natriuretic peptide, substance P and calcitonin gene-related peptide is present in the VNO...
- Molecular pathway for the localized formation of the sinoatrial nodeMathilda T M Mommersteeg
Center for Heart Failure Research, Academic Medical Centre, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
Circ Res 100:354-62. 2007....
- Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heartYuhei Hotta
Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
Dev Dyn 237:2947-54. 2008..The embryonic heart phenotype is similar to that of the Fgf9 knockout heart, indicating Fgf9 and Fgf16 to synergistically act as growth factors for embryonic cardiomyocytes...
- Expression of Slit and Robo genes in the developing mouse heartCaroline Medioni
Institute of Developmental Biology and Cancer, CNRS UMR 6543, Faculte des Sciences, Parc Valrose Nice, France
Dev Dyn 239:3303-11. 2010..Our results suggest that patterned Slit-Robo signaling may contribute to the control of oriented cell growth during chamber morphogenesis of the mammalian heart...
- Go protein subunit Goα and the secretory process of the natriuretic peptide hormones ANF and BNPCassandra Roeske
Cardiovascular Endocrinology LaboratoryUniversity of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7Department of Pathology and Laboratory MedicineFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5Experimental Therapeutics and MetabolismMcGill University Health Centre Research Institute, and Departments of Medicine, Physiology and Human Genetics, McGill University, Montreal, Quebec, CanadaToronto General Hospital200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
J Mol Endocrinol 54:277-88. 2015..has been shown to be prominent in the atria of the rat heart and to be significantly associated with atrial natriuretic factor (ANF)-containing atrial-specific secretory granules by immunocytochemistry...
- Importance of Endogenous Atrial and Brain Natriuretic Peptides in Murine Embryonic Vascular and Organ DevelopmentTakeshi Tokudome
Department of Biochemistry T T, I K, H N, M M, National Cerebral and Cardiovascular Research Center, Suita, Osaka, 565 8565 Japan Department of Cardiovascular Research T S, T K, Shinshu University Graduate School of Medicine, Shinshu, 565 8565 Japan Department of Anatomy H K, Kyorin University School of Medicine, Mitaka, Tokyo, 565 8565 Japan Tissue Engineering and Regenerative Medicine K O, National Cerebral and Cardiovascular Research Center, Suita, Osaka, 565 8565 Japan Department of Cardiorenal and Cerebrovascular Medicine M K, Kagawa University Faculty of Medicine, Kagawa, 565 8565 Japan Kyoto University Graduate School of Medicine Medical Innovation Center K N, Kyoto, 565 8565 Japan and Director General K K, National Cerebral and Cardiovascular Research Center, Suita, Osaka, 565 8565 Japan
Endocrinology 157:358-67. 2016b>Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) bind to the receptor guanylyl cyclase (GC)-A, leading to diuresis, natriuresis, and blood vessel dilation...
- The structure of rat preproatrial natriuretic factor as defined by a complementary DNA cloneC E Seidman
Science 225:324-6. 1984..b>Atrial natriuretic factor is located at the carboxyl terminus of the precursor molecule...
- HNF-1 alpha and HNF-1 beta expression in mouse intestinal cryptsM S Serfas
Department of Genetics, University of Illinois College of Medicine, Chicago 60612
Am J Physiol 265:G506-13. 1993..Although HNF-1 is necessary for transcription of the AFP gene, other factors must be involved in eliciting the cell type-specific pattern of AFP expression in the intestine...
- Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tubeT X O'Brien
Department of Medicine, Veterans Administration Medical Center, La Jolla, CA
Proc Natl Acad Sci U S A 90:5157-61. 1993..Since the 250-base-pair promoter fragment is active developmentally in transgenic mice, this establishes it as a molecular target for the process of ventricular specification in the developing heart tube...
- A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2E C Svensson
Department of Medicine, University of Chicago, Chicago, Illinois, USA
Nat Genet 25:353-6. 2000..Our findings indicate the importance of Zfpm2 in the normal looping and septation of the heart and suggest a genetic basis for the syndrome of tricuspid atresia...
- Hypoxia reduces atrial natriuretic peptide clearance receptor gene expression in ANP knockout miceJ Z Sun
Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Am J Physiol Lung Cell Mol Physiol 279:L511-9. 2000..is associated with exacerbated pulmonary hypertension and right ventricular (RV) enlargement, reduced atrial natriuretic peptide (ANP) clearance receptor (NPR-C) expression, and enhanced B-type natriuretic peptide (BNP) expression in ..
- Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndromeT K Ghosh
Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
Hum Mol Genet 10:1983-94. 2001..are present in the upstream regions of several cardiac-expressed genes including cardiac alpha actin, atrial natriuretic factor, cardiac myosin heavy chain alpha, cardiac myosin heavy chain beta, myosin light chain 1A, myosin light ..
- Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferationLei Wei
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
Development 129:1705-14. 2002..These results reveal new biological functions for Rho family proteins as essential determinants of cell proliferation signals at looping and chamber maturation stages in mammalian cardiac development...
- A potential role for the endothelin ETA receptor in salt-sensitive hypertension of the proANP gene-disrupted mouseP F O'Tierney
Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario, Canada
Mol Cell Biochem 275:57-66. 2005We have previously shown that the partial disruption of the gene for atrial natriuretic peptide (ANP) results in a salt-sensitive phenotype...
- Interactions between angiotensin ll and atrial natriuretic peptide in renomedullary interstitial cells: the role of neutral endopeptidaseChristine Maric
Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
Nephron Physiol 103:p149-56. 2006..Neutral endopeptidase (NEP) inhibition attenuates renal damage in the diabetic kidney, but little is known about the mechanisms of this renoprotective effect...
- Reptilian heart development and the molecular basis of cardiac chamber evolutionKazuko Koshiba-Takeuchi
Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Nature 461:95-8. 2009..Our findings provide a molecular mechanism for the evolution of the amniote ventricle, and support the concept that altered expression of developmental regulators is a key mechanism of vertebrate evolution...
- Atrial natriuretic peptide protects against Staphylococcus aureus-induced lung injury and endothelial barrier dysfunctionJunjie Xing
Section of Pulmonary and Critical Care and Lung Injury Center, Department of Medicine, University of Chicago, Chicago, Illinois, USA
J Appl Physiol (1985) 110:213-24. 2011..Protective effects of atrial natriuretic peptide (ANP) have been shown against inflammatory signaling and endothelial barrier dysfunction induced by gram-..
- UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental programSeunghee Lee
Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
Dev Cell 22:25-37. 2012....
- CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophyZhan Peng Huang
Department of Cardiology, Children s Hospital Boston, Harvard Medical School, MA 02115, USA
Circ Res 110:818-30. 2012..Whereas the regulatory pathways that activate cardiac hypertrophy have been well-established, the molecular events that inhibit or repress cardiac hypertrophy are less known...
- Cyclin D2 rescues size and function of GATA4 haplo-insufficient heartsAbir Yamak
Laboratory of Cardiac Development and Differentiation, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
Am J Physiol Heart Circ Physiol 303:H1057-66. 2012..The finding that postnatal upregulation of a cell-cycle gene in GATA4 haplo-insufficient hearts may be protective opens new avenues for maintaining or restoring cardiac function in GATA4-dependent cardiac disease...
- Salt-sensitive hypertension and cardiac hypertrophy in transgenic mice expressing a corin variant identified in blacksWei Wang
Department of Molecular Cardiology, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
Hypertension 60:1352-8. 2012..The results indicate that corin defects may represent an important mechanism in salt-sensitive hypertension and cardiac hypertrophy in blacks...
- Isolation and mapping of four new DNA markers from mouse chromosome 4M Krall
Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20892
Mamm Genome 3:653-5. 1992
- Molecular cloning and expression of murine guanylate cyclase/atrial natriuretic factor receptor cDNAK N Pandey
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
J Biol Chem 265:12342-8. 1990The potent diuretic and natriuretic peptide hormone atrial natriuretic factor (ANF), with vasodilatory activity also stimulates steroidogenic responsiveness in Leydig cells...
- A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenesJ D Ceci
Mammalian Genetics Laboratory, BRI Basic Research Program, NCI Frederick Cancer Research Facility, Maryland 21701
Genomics 5:699-709. 1989..Additional loci mapped in this study to chromosome 4 were Tsha, Mup-1, Rrm2-ps1, Ifa, and Anf. A comparison of our mapping data with inbred strain mapping data did not show any evidence for inversions or ..
- Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damageM Potter
Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20892
Genomics 2:257-62. 1988....
- Genomic organization and genetic mapping of the neuroimmune gene I2rf5 to mouse chromosome 4M V Autieri
Department of Cardiovascular Pharmacy, Smith Kline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
Genomics 25:282-4. 1995..The gene encoding F5, termed I2rf5, was mapped using interspecies mouse crosses in close proximity to a number of genes associated with neuronal defects on distal chromosome 4...
- Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs. Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptidesN Tamura
Department of Medicine, Kyoto University Faculty of Medicine, Japan
J Clin Invest 94:1059-68. 1994Brain and atrial natriuretic peptides (BNP and ANP) are cardiac hormones with diuretic, natriuretic, and vasodilatory activities. Cardiomyopathic hamsters are widely used animal models of heart failure...
- In vitro chamber specification during embryonic stem cell cardiogenesis. Expression of the ventricular myosin light chain-2 gene is independent of heart tube formationW C Miller-Hance
Department of Medicine, University of California, San Diego, School of Medicine, La Jolla 92093
J Biol Chem 268:25244-52. 1993..These data establish the mouse embryonic stem cell system as a model for cardiac chamber specification and suggest a promising approach in the study of regional specification in genetically engineered cardiac muscle cells...
- Mapping of multiple mouse loci related to the farnesyl pyrophosphate synthetase geneA Andalibi
Department of Medicine, University of California, Los Angeles 90024
Mamm Genome 4:211-9. 1993..It is presently unclear which of these loci encode active prenyltransferases and which may correspond to pseudogenes. The strongly hybridizing loci provide convenient genetic markers for seven mouse chromosomes...
- Riz maps to distal chromosome 4 near genes involved in tumorigenesis and nerve degenerationB A Mock
National Cancer Institute, National Institutes of Health, Building 37, Room 2B08, 37 Convent Dr MSC 4255, Bethesda, Maryland 20892 4255, USA
Mamm Genome 7:637. 1996
- Blood pressure and fluid-electrolyte balance in mice with reduced or absent ANPS W John
Department of Pathology, University of North Carolina, Chapel Hill 27599 7020, USA
Am J Physiol 271:R109-14. 1996b>Atrial natriuretic peptide (ANP)-gene knockout mice of three genotypes (+/+, +/-, and -/-) were maintained on a low-salt diet (0.008% NaCl). They were then fed either the same low-salt diet or a high-salt diet (8% NaCl) for 1 wk...
- Organization of the mouse cardiac natriuretic peptide locus encoding BNP and ANPH Huang
Department of Medicine, University of Alabama, Birmingham, USA
J Mol Cell Cardiol 28:1823-8. 1996The genes encoding the mouse atrial natriuretic peptide and B-type natriuretic peptide were previously shown to be physically linked on mouse chromosome 4 (Steinhelper ME, 1993, Structure, expression, and genomic mapping of the mouse ..
- Natural resistance to Mycoplasma pulmonis infection in mice: host resistance gene(s) map to chromosome 4W C Lai
Division of Comparative Medicine, University of Texas Southwestern Medical Center, Dallas 75235 9072, USA
Nat Immun 15:241-8. 1996....
- Salt-sensitive hypertension in ANP knockout mice is prevented by AT1 receptor antagonist losartanL G Melo
Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Am J Physiol 277:R624-30. 1999Mice harboring a functional deletion of the pro-atrial natriuretic peptide (ANP) gene (-/-) develop salt-sensitive hypertension relative to their wild-type (+/+) counterparts after prolonged (>1 wk) maintenance on high-salt (HS, 8% ..
- Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heartV M Christoffels
Experimental and Molecular Cardiology Group, University of Amsterdam, The Netherlands
Dev Biol 224:263-74. 2000..The spatiodevelopmental pattern of Irx5 matched that of ANF, a marker for the forming working myocardium of the chambers...
- Expression of Irx6 during mouse morphogenesisJ Mummenhoff
Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
Mech Dev 103:193-5. 2001..Here, we investigated the expression pattern of Irx6 during mouse morphogenesis and early organogenesis. The pattern was found to be much more restricted compared to the other five Irx genes, and its level of expression was much lower...
- Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynxM Tanaka
Cardiovascular Division, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Mol Cell Biol 21:4391-8. 2001..Furthermore, the development of the atrium was less advanced in the double-mutant embryos, indicating that these two genes are essential for both pharyngeal and cardiac development...
- Processing of pro-atrial natriuretic peptide by corin in cardiac myocytesFaye Wu
Department of Cardiovascular Research, Berlex Biosciences, Richmond, California 94804, USA
J Biol Chem 277:16900-5. 2002..In a previous study using transfected 293 cells, we showed that corin converted pro-atrial natriuretic peptide (pro-ANP) to atrial natriuretic peptide (ANP), suggesting that corin is likely the pro-ANP convertase...
- Chimeric analysis of retinoic acid receptor function during cardiac loopingAngelo Iulianella
Laboratory of Molecular and Cellular Biology, Institut de Recherches Cliniques de Montreal, Quebec, Canada
Dev Biol 247:62-75. 2002..This work suggests a role for RAR signaling in late looping morphogenesis and illustrates the utility of using a dominant-negative gene substitution approach to circumvent the functional redundancy inherent to the RAR family...
- The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesisManabu Shirai
Department of Developmental Biology and Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari, Japan
J Clin Invest 110:177-84. 2002..5 expression in cardiomyocytes. Thus, our data show that a mammalian PcG gene can play a key role in organogenesis by helping to maintain the expression of a selector gene...
- Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytesKoji Wakimoto
Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, 3 16 89 Kashima, Yodogawa ku, Osaka 532 8505, Japan
Comp Biochem Physiol B Biochem Mol Biol 135:9-15. 2003..Although NCX1 protein levels were decreased in heterozygous mice, there were no changes in NCX2 and NCX3 protein levels between wild type and heterozygous mice...
- Pressure-independent enhancement of cardiac hypertrophy in atrial natriuretic peptide-deficient miceJi An Feng
Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Clin Exp Pharmacol Physiol 30:343-9. 20031. Homozygous deletion of the pro-atrial natriuretic peptide (Nppa) gene (ANP-/-) has been associated with both cardiac hypertrophy and salt-sensitive hypertension in mice, suggesting that cardiac hypertrophy in ANP-/- mice may be related,..
- Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturationBin Wang
Department of Molecular Genetics and The Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
Development 131:4477-87. 2004....
- Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targetsZhiyv Niu
Center for Cardiovascular Development, Division of Cardiovascular Sciences, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
J Biol Chem 280:32531-8. 2005....
- Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal heartsAndreas Fischer
Theodor Boveri Institute, Physiological Chemistry I, University of Wuerzburg, Germany
Mol Cell Biol 25:8960-70. 2005..Loss of Hey1/2 leads to elevated GATA4/6 and ANF mRNA levels in embryoid bodies, while forced expression of Hey factors strongly represses expression of the GATA4 ..
- Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valvesJin Wen Chen
Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, USA
Circ Res 98:923-30. 2006..expression of N-myc in the hyperplastic myocardium and attenuated expression of the trabecular markers atrial natriuretic factor and bone morphogenic protein 10 indicated that proliferating cardiomyocytes had failed to differentiate ..
- Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart fieldSonja Nowotschin
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Development 133:1565-73. 2006..5. The results presented in this study unravel a novel Tbx1-Pitx2 pathway linking Tbx1 to asymmetric cardiac morphogenesis...
- Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heartKiyoko Hattori
Department of Pediatrics, Graduate School of Medical Science, Kumamoto University, Japan
Mol Genet Metab 91:285-93. 2007..Our findings support calreticulin being critical for normal heart function and structure. These mice are a useful model for the study of endoplasmic reticulum proteins, such as calreticulin, in various tissues...
- Glucocorticoid modulation of atrial natriuretic peptide, oxytocin, vasopressin and Fos expression in response to osmotic, angiotensinergic and cholinergic stimulationF Lauand
Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida dos Bandeirantes, 3900 Monte Alegre, CEP 14049 900 Ribeirao Preto, SP, Brazil
Neuroscience 147:247-57. 2007..In the present study, we evaluated the effect of dexamethasone on atrial natriuretic peptide (ANP), oxytocin (OT) and vasopressin (AVP) responses to i.c.v. microinjections of 0.15 M and 0...
- Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathyEdwin P Kirk
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, 2010, Australia
Am J Hum Genet 81:280-91. 2007..They provide insights into how mutation of different genes in an interactive regulatory circuit lead to diverse clinical phenotypes, with implications for diagnosis, genetic screening, and patient follow-up...
- Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defectsElisabeth A Gustafson-Wagner
Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
Am J Physiol Heart Circ Physiol 293:H2680-92. 2007..The mXinalpha-knockout mouse line provides a novel model of cardiac hypertrophy and cardiomyopathy with conduction defects...
- The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic developmentDavid Y Lou
Boston University Medical Center, 650 Albany Street, Boston, MA 02118, USA
Mol Cell Biol 28:131-9. 2008..Defects in the formation of the heart lead to hydrops fetalis and are likely the cause of embryonic lethality. Thus, CK2alpha appears to play an essential and uncompensated role in mammalian development...
- SALL1 truncated protein expression in Townes-Brocks syndrome leads to ectopic expression of downstream genesSusan M Kiefer
Research and Education Service Line, St Louis Veterans Administration Medical Center, U S Department of Veterans Affairs, St Louis, Missouri 63106, USA
Hum Mutat 29:1133-40. 2008..mutant protein is capable of dominant negative activity that results in ectopic activation of two downstream genes, Nppa and Shox2, in the developing heart and limb...
- Differential protein expression in heart in UT-B null mice with cardiac conduction defectsHao Yu
Department of Pathophysiology, Research Center of Prostate Diseases, School of Basic Medicine, Jilin University, Changchun, P R China
Proteomics 9:504-11. 2009..UT-B null mice at early stage prior to the development of P-R interval elongation, while the change of atrial natriuretic peptide (ANP) occurred only at late stage in UT-B null mice that had the AV block...
- Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5Ramón A Espinoza-Lewis
Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
Dev Biol 327:376-85. 2009..Genetically, the lack of Tbx3 and Hcn4 expression, along with ectopic activation of Nppa, Cx40, and Nkx2-5 in the Shox2(-/-) SAN region, indicates a failure in SAN differentiation...
- Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expressionIrina I Nagy
Department of Medical Biochemistry and Molecular Biology, University of Oulu, 90014 Oulu, Finland
Cardiovasc Res 85:100-9. 2010..We have addressed the potential role of Wnt-11 in the control of early ventricular myocardium assembly...
- Hypertrophic gene expression induced by chronic stretch of excised mouse heart muscleAnna M Raskin
Department of Bioengineering, University of California San Diego, CA 92093, USA
Mol Cell Biomech 6:145-59. 2009..The system was able to measure the induction of hypertrophic markers (BNP, ANP) in tissue after 2 hrs and 5 hrs of stretch...
- Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during developmentNicola J A Scott
Department of Medicine, University of Otago Christchurch, P O Box 4345, Christchurch, New Zealand
Biochim Biophys Acta 1792:1175-84. 2009..and an induction of a panel of genes normally expressed in the embryonic and neonatal ventricle, such as atrial natriuretic peptide (ANP)...
- ANP-mediated inhibition of distal nephron fractional sodium reabsorption in wild-type and mice overexpressing natriuretic peptide receptorDi Zhao
Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center School of Medicine, New Orleans, Louisiana 70112, USA
Am J Physiol Renal Physiol 298:F103-8. 2010b>Atrial natriuretic peptide (ANP) elicits natriuresis; however, the relative contributions of proximal and distal nephron segments to the overall ANP-induced natriuresis have remained uncertain...
- Atrial natriuretic peptide reduces vascular leakage and choroidal neovascularizationNuria Lara-Castillo
Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
Am J Pathol 175:2343-50. 2009b>Atrial natriuretic peptide (ANP) is a hormone with diuretic, natriuretic, and vasodilatory properties...
- Estrogen in pathogenesis of tubulointerstitial diseaseChristine Maric; Fiscal Year: 2003..abstract_text> ..
- HAND GENES IN CARDIAC DEVELOPMENTWilliam Pu; Fiscal Year: 2004..This experience, and the information generated in this plan, will launch the applicant's career as an independent investigator. ..
- EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTIONRichard Tsika; Fiscal Year: 2008..abstract_text> ..
- ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPERichard Tsika; Fiscal Year: 2009..abstract_text> ..