Nppa

Summary

Gene Symbol: Nppa
Description: natriuretic peptide type A
Alias: ANP, Anf, Pnd, natriuretic peptides A, atrial natriuretic factor, atrial natriuretic peptide, natriuretic peptide precursor type A, prepronatriodilatin
Species: mouse

Top Publications

  1. ncbi GATA4 transcription factor is required for ventral morphogenesis and heart tube formation
    C T Kuo
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Genes Dev 11:1048-60. 1997
  2. pmc Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression
    J Wang
    Department of Molecular Medicine, Karolinska Institutet, L8 02, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 98:4038-43. 2001
  3. ncbi Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension
    S W John
    Department of Pathology, University of North Carolina, Chapel Hill 27599
    Science 267:679-81. 1995
  4. ncbi Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
    J D Molkentin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Genes Dev 11:1061-72. 1997
  5. ncbi Chamber formation and morphogenesis in the developing mammalian heart
    V M Christoffels
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105, The Netherlands
    Dev Biol 223:266-78. 2000
  6. ncbi A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
    B G Bruneau
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 106:709-21. 2001
  7. pmc Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3
    Vinciane Gaussin
    Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:2878-83. 2002
  8. pmc Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation
    Petra E M H Habets
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Genes Dev 16:1234-46. 2002
  9. ncbi The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene
    Bijoy D Thattaliyath
    Department of Physiology, Mail code 7756, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Mol Cell Cardiol 34:1335-44. 2002
  10. ncbi PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5
    Mrudula Ganga
    Department of Biological Science, The University of Tulsa, Tulsa, Oklahoma 74104 3189, USA
    J Biol Chem 278:22437-45. 2003

Research Grants

Scientific Experts

Detail Information

Publications133 found, 100 shown here

  1. ncbi GATA4 transcription factor is required for ventral morphogenesis and heart tube formation
    C T Kuo
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Genes Dev 11:1048-60. 1997
    ..However, they define a critical role for GATA4 in regulating the rostral-to-caudal and lateral-to-ventral folding of the embryo that is needed for normal cardiac morphogenesis...
  2. pmc Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression
    J Wang
    Department of Molecular Medicine, Karolinska Institutet, L8 02, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 98:4038-43. 2001
    ..It would therefore be of interest to determine whether manipulation of respiratory chain function can be used to inhibit or enhance apoptosis in these conditions...
  3. ncbi Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension
    S W John
    Department of Pathology, University of North Carolina, Chapel Hill 27599
    Science 267:679-81. 1995
    To determine if defects in the atrial natriuretic peptide (ANP) system can cause hypertension, mice were generated with a disruption of the proANP gene...
  4. ncbi Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
    J D Molkentin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Genes Dev 11:1061-72. 1997
    ..We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP...
  5. ncbi Chamber formation and morphogenesis in the developing mammalian heart
    V M Christoffels
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105, The Netherlands
    Dev Biol 223:266-78. 2000
    ..We traced the spatial pattern of expression of genes encoding atrial natriuretic factor, sarcoplasmic reticulum calcium ATPase, Chisel, Irx5, Irx4, myosin light chain 2v, and beta-myosin heavy ..
  6. ncbi A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
    B G Bruneau
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 106:709-21. 2001
    ..Surprisingly, Tbx5 haploinsufficiency also markedly decreased atrial natriuretic factor (ANF) and connexin 40 (cx40) transcription, implicating these as Tbx5 target genes and providing a ..
  7. pmc Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3
    Vinciane Gaussin
    Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:2878-83. 2002
    ..Hence, ALK3 is essential, beyond just the egg cylinder stage, for myocyte-dependent functions and signals in cardiac organogenesis...
  8. pmc Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation
    Petra E M H Habets
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Genes Dev 16:1234-46. 2002
    ..The atrial natriuretic factor (ANF) gene is specifically expressed in this developing chamber myocardium and is one of the first ..
  9. ncbi The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene
    Bijoy D Thattaliyath
    Department of Physiology, Mail code 7756, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Mol Cell Cardiol 34:1335-44. 2002
    ..transcriptional targets, we have determined that HAND2 regulates the transcription of the Atrial Naturetic Peptide (ANP) gene. Results show that ANP expression is reduced in HAND2 null mice...
  10. ncbi PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5
    Mrudula Ganga
    Department of Biological Science, The University of Tulsa, Tulsa, Oklahoma 74104 3189, USA
    J Biol Chem 278:22437-45. 2003
    ..We report here that the atrial natriuretic factor (ANF) promoter is a target of PITX2...
  11. pmc The serum response factor coactivator myocardin is required for vascular smooth muscle development
    Shijie Li
    Departments of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 100:9366-70. 2003
    ..5 and show no evidence of vascular SMC differentiation. Myocardin is the only transcription factor known to be necessary and sufficient for vascular SMC differentiation...
  12. ncbi Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis
    Jun K Takeuchi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara 630 0101, Japan
    Development 130:5953-64. 2003
    ..In such heart, left ventricle (LV)-specific ANF gene was induced...
  13. ncbi T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
    Vincent M Christoffels
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dev Dyn 229:763-70. 2004
    ..and protein expression in mouse hearts was found to be complementary to that of chamber myocardium-specific genes Nppa, Cx40, Cx43, and Chisel, and was conserved in human...
  14. pmc BMP10 is essential for maintaining cardiac growth during murine cardiogenesis
    Hanying Chen
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Development 131:2219-31. 2004
    ..This may provide an underlying mechanism for understanding the pathogenesis of both structural and functional congenital heart defects...
  15. pmc Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart
    Kiyonori Togi
    Department of Social Service, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Mol Cell Biol 24:4627-35. 2004
    ..Furthermore, expression of Hand1/eHAND in the whole ventricles altered the expression patterns of Chisel, ANF, and Hand2/dHAND but did not affect Tbx5 expression...
  16. ncbi The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart
    Willem M H Hoogaars
    Experimental and Molecular Cardiology Group, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Cardiovasc Res 62:489-99. 2004
    ..We studied the developmental expression pattern and functional aspects of the T-box transcription factor Tbx3, a novel marker for the murine central conduction system (CCS)...
  17. ncbi Lineage and morphogenetic analysis of the cardiac valves
    Frederik J de Lange
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 95:645-54. 2004
    ..The tricuspid septal leaflet then delaminates from the muscular ventricular septum late in development...
  18. ncbi Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 131:5041-52. 2004
    ....
  19. ncbi GATA4 is a dosage-sensitive regulator of cardiac morphogenesis
    William T Pu
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    Dev Biol 275:235-44. 2004
    ..Surprisingly, expression levels of the putative GATA4 target genes ANF, BNP, MEF2C, Nkx2-5, cyclin D2, and BMP4 were unchanged in mutant hearts, suggesting that GATA4 is not a dose-..
  20. ncbi The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner
    David G McFadden
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Development 132:189-201. 2005
    ..These findings demonstrate that Hand factors play pivotal and partially redundant roles in cardiac morphogenesis, cardiomyocyte differentiation and cardiac-specific transcription...
  21. ncbi T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Development 132:2475-87. 2005
    ....
  22. ncbi Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development
    Jun K Takeuchi
    Cardiovascular Research, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
    Development 132:2463-74. 2005
    ..We conclude that Tbx20 is positioned at a critical node in transcription factor networks required for heart and motoneuron development where it dose-dependently regulates gene expression...
  23. pmc Morphogenesis of the right ventricle requires myocardial expression of Gata4
    Elisabeth M Zeisberg
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 115:1522-31. 2005
    ..Our results demonstrate a general role of myocardial Gata4 in regulating cardiomyocyte proliferation and a specific, stage-dependent role in regulating the morphogenesis of the RV and the atrioventricular canal...
  24. ncbi Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
    Lijiang Ma
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:5601-11. 2005
    ..Our data indicate that Bmp2 has a crucial role in coordinating multiple aspects of AV canal morphogenesis...
  25. ncbi Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart
    Kazuko Koshiba-Takeuchi
    Programs in Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Nat Genet 38:175-83. 2006
    ..Thus, a positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes...
  26. ncbi Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity
    Chinmay M Trivedi
    Department of Cell and Developmental Biology, 1156 Basic Research Building II, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Med 13:324-31. 2007
    ....
  27. pmc Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodeling
    Ines Ribeiro
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS ONE 2:e398. 2007
    ..Cardiomyocytes in the future chamber myocardium acquire different cellular and physiological characteristics through activation of a chamber-specific genetic program, which is in part mediated by T-box genes...
  28. doi Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system
    Martijn L Bakker
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 102:1340-9. 2008
    ..5 and 15.5, ectopically expressed genes for connexin (Cx)43, atrial natriuretic factor (Nppa), Tbx18, and Tbx20 in the atrioventricular bundle and proximal bundle branches...
  29. pmc Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium
    Yi Hui Chen
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center and Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
    BMC Dev Biol 8:75. 2008
    ....
  30. pmc Alternative splicing of the guanylyl cyclase-A receptor modulates atrial natriuretic peptide signaling
    Michael Hartmann
    Institute of Physiology, University of Wurzburg, D 97070 Wurzburg, Germany
    J Biol Chem 283:28313-20. 2008
    Atrial (ANP) and B-type natriuretic peptides (BNP) modulate blood pressure and volume through the stimulation of cyclic GMP production by their guanylyl cyclase-A (GC-A) receptor...
  31. pmc Tbx3 is required for outflow tract development
    Karim Mesbah
    Developmental Biology Institute of Marseilles Luminy, France
    Circ Res 103:743-50. 2008
    ....
  32. pmc microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart
    Ning Liu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 22:3242-54. 2008
    ....
  33. pmc MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
    Thomas E Callis
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Clin Invest 119:2772-86. 2009
    ..Together, our studies uncover what we believe are novel miRNA-dependent mechanisms that modulate cardiac hypertrophy and electrical conduction...
  34. doi Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium
    Donna Lai
    Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool St, Darlinghurst 2010, Australia
    Circ Res 107:715-27. 2010
    ..In development, the membrane-tethered signaling ligand Neuregulin (Nrg)1, expressed in endocardium, is essential for ventricular morphogenesis. In adults, Nrg1 protects against heart failure and can induce cardiomyocytes to divide...
  35. doi GATA5 interacts with GATA4 and GATA6 in outflow tract development
    Brigitte Laforest
    Laboratoire de développement et différentiation cardiaque, Programme de biologie moléculaire, Universite de Montreal, Montreal QC, Canada H3C 3J7
    Dev Biol 358:368-78. 2011
    ..The data identify GATA5 as a potential genetic modifier of congenital heart disease and provide insight for elucidating the genetic basis of an important class of human birth defects...
  36. pmc Polycomb repressive complex 2 regulates normal development of the mouse heart
    Aibin He
    Department of Cardiology, Children s Hospital Boston, MA, USA
    Circ Res 110:406-15. 2012
    ..Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27, which establishes H3K27me3 repressive epigenetic marks that promote tissue-specific differentiation by silencing ectopic gene programs...
  37. pmc Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
    Nat Genet 44:343-7. 2012
    ..Our results suggest that epigenetic dysregulation in embryonic progenitor cells is a predisposing factor for adult disease and dysregulated stress responses...
  38. ncbi Localized expression of the atrial natriuretic factor gene during cardiac embryogenesis
    R Zeller
    Department of Genetics, Harvard Medical School, Boston, Massachusetts
    Genes Dev 1:693-8. 1987
    Expression of the gene encoding atrial natriuretic factor (ANF) during mouse cardiac embryogenesis was studied using in situ hybridization to histologic sections...
  39. ncbi The gene for Lap18, leukemia-associated phosphoprotein p18 (metablastin), maps to distal mouse chromosome 4
    B A Mock
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Mamm Genome 4:461-2. 1993
  40. pmc Mouse Pop1 is required for muscle regeneration in adult skeletal muscle
    Birgit Andrée
    Cell and Molecular Biology, Technical University Braunschweig, Braunschweig, Germany
    Mol Cell Biol 22:1504-12. 2002
    ..In homozygotes, persistence of LacZ expression and a retarded ability to regenerate skeletal muscle were apparent, suggesting that Pop1 plays a role in muscle regeneration...
  41. ncbi Overexpression of Polycomb-group gene rae28 in cardiomyocytes does not complement abnormal cardiac morphogenesis in mice lacking rae28 but causes dilated cardiomyopathy
    Hideyuki Koga
    Department of Developmental Biology and Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari, Osaka, Japan
    Lab Invest 82:375-85. 2002
    ..rae28-induced dilated cardiomyopathy may thus provide a clue for clarifying the direct role of PcG in the maintenance of cardiomyocytes...
  42. ncbi Neuronal nitric oxide synthase expression in the mouse vomeronasal organ during prenatal development
    Carlo Zancanaro
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, Universita di Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Eur J Neurosci 16:659-64. 2002
    ..No immunoreactivity for atrial natriuretic peptide, substance P and calcitonin gene-related peptide is present in the VNO...
  43. ncbi Molecular pathway for the localized formation of the sinoatrial node
    Mathilda T M Mommersteeg
    Center for Heart Failure Research, Academic Medical Centre, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Circ Res 100:354-62. 2007
    ....
  44. doi Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart
    Yuhei Hotta
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
    Dev Dyn 237:2947-54. 2008
    ..The embryonic heart phenotype is similar to that of the Fgf9 knockout heart, indicating Fgf9 and Fgf16 to synergistically act as growth factors for embryonic cardiomyocytes...
  45. pmc Expression of Slit and Robo genes in the developing mouse heart
    Caroline Medioni
    Institute of Developmental Biology and Cancer, CNRS UMR 6543, Faculte des Sciences, Parc Valrose Nice, France
    Dev Dyn 239:3303-11. 2010
    ..Our results suggest that patterned Slit-Robo signaling may contribute to the control of oriented cell growth during chamber morphogenesis of the mammalian heart...
  46. doi Go protein subunit Goα and the secretory process of the natriuretic peptide hormones ANF and BNP
    Cassandra Roeske
    Cardiovascular Endocrinology LaboratoryUniversity of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7Department of Pathology and Laboratory MedicineFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5Experimental Therapeutics and MetabolismMcGill University Health Centre Research Institute, and Departments of Medicine, Physiology and Human Genetics, McGill University, Montreal, Quebec, CanadaToronto General Hospital200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    J Mol Endocrinol 54:277-88. 2015
    ..has been shown to be prominent in the atria of the rat heart and to be significantly associated with atrial natriuretic factor (ANF)-containing atrial-specific secretory granules by immunocytochemistry...
  47. doi Importance of Endogenous Atrial and Brain Natriuretic Peptides in Murine Embryonic Vascular and Organ Development
    Takeshi Tokudome
    Department of Biochemistry T T, I K, H N, M M, National Cerebral and Cardiovascular Research Center, Suita, Osaka, 565 8565 Japan Department of Cardiovascular Research T S, T K, Shinshu University Graduate School of Medicine, Shinshu, 565 8565 Japan Department of Anatomy H K, Kyorin University School of Medicine, Mitaka, Tokyo, 565 8565 Japan Tissue Engineering and Regenerative Medicine K O, National Cerebral and Cardiovascular Research Center, Suita, Osaka, 565 8565 Japan Department of Cardiorenal and Cerebrovascular Medicine M K, Kagawa University Faculty of Medicine, Kagawa, 565 8565 Japan Kyoto University Graduate School of Medicine Medical Innovation Center K N, Kyoto, 565 8565 Japan and Director General K K, National Cerebral and Cardiovascular Research Center, Suita, Osaka, 565 8565 Japan
    Endocrinology 157:358-67. 2016
    b>Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) bind to the receptor guanylyl cyclase (GC)-A, leading to diuresis, natriuresis, and blood vessel dilation...
  48. ncbi The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone
    C E Seidman
    Science 225:324-6. 1984
    ..b>Atrial natriuretic factor is located at the carboxyl terminus of the precursor molecule...
  49. ncbi HNF-1 alpha and HNF-1 beta expression in mouse intestinal crypts
    M S Serfas
    Department of Genetics, University of Illinois College of Medicine, Chicago 60612
    Am J Physiol 265:G506-13. 1993
    ..Although HNF-1 is necessary for transcription of the AFP gene, other factors must be involved in eliciting the cell type-specific pattern of AFP expression in the intestine...
  50. pmc Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube
    T X O'Brien
    Department of Medicine, Veterans Administration Medical Center, La Jolla, CA
    Proc Natl Acad Sci U S A 90:5157-61. 1993
    ..Since the 250-base-pair promoter fragment is active developmentally in transgenic mice, this establishes it as a molecular target for the process of ventricular specification in the developing heart tube...
  51. ncbi A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2
    E C Svensson
    Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Nat Genet 25:353-6. 2000
    ..Our findings indicate the importance of Zfpm2 in the normal looping and septation of the heart and suggest a genetic basis for the syndrome of tricuspid atresia...
  52. ncbi Hypoxia reduces atrial natriuretic peptide clearance receptor gene expression in ANP knockout mice
    J Z Sun
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Physiol Lung Cell Mol Physiol 279:L511-9. 2000
    ..is associated with exacerbated pulmonary hypertension and right ventricular (RV) enlargement, reduced atrial natriuretic peptide (ANP) clearance receptor (NPR-C) expression, and enhanced B-type natriuretic peptide (BNP) expression in ..
  53. ncbi Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome
    T K Ghosh
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Hum Mol Genet 10:1983-94. 2001
    ..are present in the upstream regions of several cardiac-expressed genes including cardiac alpha actin, atrial natriuretic factor, cardiac myosin heavy chain alpha, cardiac myosin heavy chain beta, myosin light chain 1A, myosin light ..
  54. ncbi Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation
    Lei Wei
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Development 129:1705-14. 2002
    ..These results reveal new biological functions for Rho family proteins as essential determinants of cell proliferation signals at looping and chamber maturation stages in mammalian cardiac development...
  55. ncbi A potential role for the endothelin ETA receptor in salt-sensitive hypertension of the proANP gene-disrupted mouse
    P F O'Tierney
    Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario, Canada
    Mol Cell Biochem 275:57-66. 2005
    We have previously shown that the partial disruption of the gene for atrial natriuretic peptide (ANP) results in a salt-sensitive phenotype...
  56. ncbi Interactions between angiotensin ll and atrial natriuretic peptide in renomedullary interstitial cells: the role of neutral endopeptidase
    Christine Maric
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Nephron Physiol 103:p149-56. 2006
    ..Neutral endopeptidase (NEP) inhibition attenuates renal damage in the diabetic kidney, but little is known about the mechanisms of this renoprotective effect...
  57. pmc Reptilian heart development and the molecular basis of cardiac chamber evolution
    Kazuko Koshiba-Takeuchi
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Nature 461:95-8. 2009
    ..Our findings provide a molecular mechanism for the evolution of the amniote ventricle, and support the concept that altered expression of developmental regulators is a key mechanism of vertebrate evolution...
  58. pmc Atrial natriuretic peptide protects against Staphylococcus aureus-induced lung injury and endothelial barrier dysfunction
    Junjie Xing
    Section of Pulmonary and Critical Care and Lung Injury Center, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    J Appl Physiol (1985) 110:213-24. 2011
    ..Protective effects of atrial natriuretic peptide (ANP) have been shown against inflammatory signaling and endothelial barrier dysfunction induced by gram-..
  59. pmc UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program
    Seunghee Lee
    Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Dev Cell 22:25-37. 2012
    ....
  60. pmc CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy
    Zhan Peng Huang
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, MA 02115, USA
    Circ Res 110:818-30. 2012
    ..Whereas the regulatory pathways that activate cardiac hypertrophy have been well-established, the molecular events that inhibit or repress cardiac hypertrophy are less known...
  61. pmc Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts
    Abir Yamak
    Laboratory of Cardiac Development and Differentiation, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    Am J Physiol Heart Circ Physiol 303:H1057-66. 2012
    ..The finding that postnatal upregulation of a cell-cycle gene in GATA4 haplo-insufficient hearts may be protective opens new avenues for maintaining or restoring cardiac function in GATA4-dependent cardiac disease...
  62. pmc Salt-sensitive hypertension and cardiac hypertrophy in transgenic mice expressing a corin variant identified in blacks
    Wei Wang
    Department of Molecular Cardiology, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Hypertension 60:1352-8. 2012
    ..The results indicate that corin defects may represent an important mechanism in salt-sensitive hypertension and cardiac hypertrophy in blacks...
  63. ncbi Isolation and mapping of four new DNA markers from mouse chromosome 4
    M Krall
    Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20892
    Mamm Genome 3:653-5. 1992
  64. ncbi Molecular cloning and expression of murine guanylate cyclase/atrial natriuretic factor receptor cDNA
    K N Pandey
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    J Biol Chem 265:12342-8. 1990
    The potent diuretic and natriuretic peptide hormone atrial natriuretic factor (ANF), with vasodilatory activity also stimulates steroidogenic responsiveness in Leydig cells...
  65. ncbi A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes
    J D Ceci
    Mammalian Genetics Laboratory, BRI Basic Research Program, NCI Frederick Cancer Research Facility, Maryland 21701
    Genomics 5:699-709. 1989
    ..Additional loci mapped in this study to chromosome 4 were Tsha, Mup-1, Rrm2-ps1, Ifa, and Anf. A comparison of our mapping data with inbred strain mapping data did not show any evidence for inversions or ..
  66. ncbi Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage
    M Potter
    Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20892
    Genomics 2:257-62. 1988
    ....
  67. ncbi Genomic organization and genetic mapping of the neuroimmune gene I2rf5 to mouse chromosome 4
    M V Autieri
    Department of Cardiovascular Pharmacy, Smith Kline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Genomics 25:282-4. 1995
    ..The gene encoding F5, termed I2rf5, was mapped using interspecies mouse crosses in close proximity to a number of genes associated with neuronal defects on distal chromosome 4...
  68. pmc Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs. Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides
    N Tamura
    Department of Medicine, Kyoto University Faculty of Medicine, Japan
    J Clin Invest 94:1059-68. 1994
    Brain and atrial natriuretic peptides (BNP and ANP) are cardiac hormones with diuretic, natriuretic, and vasodilatory activities. Cardiomyopathic hamsters are widely used animal models of heart failure...
  69. ncbi In vitro chamber specification during embryonic stem cell cardiogenesis. Expression of the ventricular myosin light chain-2 gene is independent of heart tube formation
    W C Miller-Hance
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla 92093
    J Biol Chem 268:25244-52. 1993
    ..These data establish the mouse embryonic stem cell system as a model for cardiac chamber specification and suggest a promising approach in the study of regional specification in genetically engineered cardiac muscle cells...
  70. ncbi Mapping of multiple mouse loci related to the farnesyl pyrophosphate synthetase gene
    A Andalibi
    Department of Medicine, University of California, Los Angeles 90024
    Mamm Genome 4:211-9. 1993
    ..It is presently unclear which of these loci encode active prenyltransferases and which may correspond to pseudogenes. The strongly hybridizing loci provide convenient genetic markers for seven mouse chromosomes...
  71. ncbi Riz maps to distal chromosome 4 near genes involved in tumorigenesis and nerve degeneration
    B A Mock
    National Cancer Institute, National Institutes of Health, Building 37, Room 2B08, 37 Convent Dr MSC 4255, Bethesda, Maryland 20892 4255, USA
    Mamm Genome 7:637. 1996
  72. ncbi Blood pressure and fluid-electrolyte balance in mice with reduced or absent ANP
    S W John
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7020, USA
    Am J Physiol 271:R109-14. 1996
    b>Atrial natriuretic peptide (ANP)-gene knockout mice of three genotypes (+/+, +/-, and -/-) were maintained on a low-salt diet (0.008% NaCl). They were then fed either the same low-salt diet or a high-salt diet (8% NaCl) for 1 wk...
  73. ncbi Organization of the mouse cardiac natriuretic peptide locus encoding BNP and ANP
    H Huang
    Department of Medicine, University of Alabama, Birmingham, USA
    J Mol Cell Cardiol 28:1823-8. 1996
    The genes encoding the mouse atrial natriuretic peptide and B-type natriuretic peptide were previously shown to be physically linked on mouse chromosome 4 (Steinhelper ME, 1993, Structure, expression, and genomic mapping of the mouse ..
  74. ncbi Natural resistance to Mycoplasma pulmonis infection in mice: host resistance gene(s) map to chromosome 4
    W C Lai
    Division of Comparative Medicine, University of Texas Southwestern Medical Center, Dallas 75235 9072, USA
    Nat Immun 15:241-8. 1996
    ....
  75. ncbi Salt-sensitive hypertension in ANP knockout mice is prevented by AT1 receptor antagonist losartan
    L G Melo
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Am J Physiol 277:R624-30. 1999
    Mice harboring a functional deletion of the pro-atrial natriuretic peptide (ANP) gene (-/-) develop salt-sensitive hypertension relative to their wild-type (+/+) counterparts after prolonged (>1 wk) maintenance on high-salt (HS, 8% ..
  76. ncbi Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart
    V M Christoffels
    Experimental and Molecular Cardiology Group, University of Amsterdam, The Netherlands
    Dev Biol 224:263-74. 2000
    ..The spatiodevelopmental pattern of Irx5 matched that of ANF, a marker for the forming working myocardium of the chambers...
  77. ncbi Expression of Irx6 during mouse morphogenesis
    J Mummenhoff
    Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Mech Dev 103:193-5. 2001
    ..Here, we investigated the expression pattern of Irx6 during mouse morphogenesis and early organogenesis. The pattern was found to be much more restricted compared to the other five Irx genes, and its level of expression was much lower...
  78. pmc Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx
    M Tanaka
    Cardiovascular Division, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 21:4391-8. 2001
    ..Furthermore, the development of the atrium was less advanced in the double-mutant embryos, indicating that these two genes are essential for both pharyngeal and cardiac development...
  79. ncbi Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes
    Faye Wu
    Department of Cardiovascular Research, Berlex Biosciences, Richmond, California 94804, USA
    J Biol Chem 277:16900-5. 2002
    ..In a previous study using transfected 293 cells, we showed that corin converted pro-atrial natriuretic peptide (pro-ANP) to atrial natriuretic peptide (ANP), suggesting that corin is likely the pro-ANP convertase...
  80. ncbi Chimeric analysis of retinoic acid receptor function during cardiac looping
    Angelo Iulianella
    Laboratory of Molecular and Cellular Biology, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    Dev Biol 247:62-75. 2002
    ..This work suggests a role for RAR signaling in late looping morphogenesis and illustrates the utility of using a dominant-negative gene substitution approach to circumvent the functional redundancy inherent to the RAR family...
  81. pmc The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis
    Manabu Shirai
    Department of Developmental Biology and Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari, Japan
    J Clin Invest 110:177-84. 2002
    ..5 expression in cardiomyocytes. Thus, our data show that a mammalian PcG gene can play a key role in organogenesis by helping to maintain the expression of a selector gene...
  82. ncbi Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes
    Koji Wakimoto
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, 3 16 89 Kashima, Yodogawa ku, Osaka 532 8505, Japan
    Comp Biochem Physiol B Biochem Mol Biol 135:9-15. 2003
    ..Although NCX1 protein levels were decreased in heterozygous mice, there were no changes in NCX2 and NCX3 protein levels between wild type and heterozygous mice...
  83. ncbi Pressure-independent enhancement of cardiac hypertrophy in atrial natriuretic peptide-deficient mice
    Ji An Feng
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Clin Exp Pharmacol Physiol 30:343-9. 2003
    1. Homozygous deletion of the pro-atrial natriuretic peptide (Nppa) gene (ANP-/-) has been associated with both cardiac hypertrophy and salt-sensitive hypertension in mice, suggesting that cardiac hypertrophy in ANP-/- mice may be related,..
  84. ncbi Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation
    Bin Wang
    Department of Molecular Genetics and The Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Development 131:4477-87. 2004
    ....
  85. ncbi Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets
    Zhiyv Niu
    Center for Cardiovascular Development, Division of Cardiovascular Sciences, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    J Biol Chem 280:32531-8. 2005
    ....
  86. pmc Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts
    Andreas Fischer
    Theodor Boveri Institute, Physiological Chemistry I, University of Wuerzburg, Germany
    Mol Cell Biol 25:8960-70. 2005
    ..Loss of Hey1/2 leads to elevated GATA4/6 and ANF mRNA levels in embryoid bodies, while forced expression of Hey factors strongly represses expression of the GATA4 ..
  87. ncbi Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves
    Jin Wen Chen
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, USA
    Circ Res 98:923-30. 2006
    ..expression of N-myc in the hyperplastic myocardium and attenuated expression of the trabecular markers atrial natriuretic factor and bone morphogenic protein 10 indicated that proliferating cardiomyocytes had failed to differentiate ..
  88. ncbi Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field
    Sonja Nowotschin
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 133:1565-73. 2006
    ..5. The results presented in this study unravel a novel Tbx1-Pitx2 pathway linking Tbx1 to asymmetric cardiac morphogenesis...
  89. ncbi Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart
    Kiyoko Hattori
    Department of Pediatrics, Graduate School of Medical Science, Kumamoto University, Japan
    Mol Genet Metab 91:285-93. 2007
    ..Our findings support calreticulin being critical for normal heart function and structure. These mice are a useful model for the study of endoplasmic reticulum proteins, such as calreticulin, in various tissues...
  90. ncbi Glucocorticoid modulation of atrial natriuretic peptide, oxytocin, vasopressin and Fos expression in response to osmotic, angiotensinergic and cholinergic stimulation
    F Lauand
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida dos Bandeirantes, 3900 Monte Alegre, CEP 14049 900 Ribeirao Preto, SP, Brazil
    Neuroscience 147:247-57. 2007
    ..In the present study, we evaluated the effect of dexamethasone on atrial natriuretic peptide (ANP), oxytocin (OT) and vasopressin (AVP) responses to i.c.v. microinjections of 0.15 M and 0...
  91. pmc Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy
    Edwin P Kirk
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, 2010, Australia
    Am J Hum Genet 81:280-91. 2007
    ..They provide insights into how mutation of different genes in an interactive regulatory circuit lead to diverse clinical phenotypes, with implications for diagnosis, genetic screening, and patient follow-up...
  92. pmc Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects
    Elisabeth A Gustafson-Wagner
    Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 293:H2680-92. 2007
    ..The mXinalpha-knockout mouse line provides a novel model of cardiac hypertrophy and cardiomyopathy with conduction defects...
  93. pmc The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development
    David Y Lou
    Boston University Medical Center, 650 Albany Street, Boston, MA 02118, USA
    Mol Cell Biol 28:131-9. 2008
    ..Defects in the formation of the heart lead to hydrops fetalis and are likely the cause of embryonic lethality. Thus, CK2alpha appears to play an essential and uncompensated role in mammalian development...
  94. doi SALL1 truncated protein expression in Townes-Brocks syndrome leads to ectopic expression of downstream genes
    Susan M Kiefer
    Research and Education Service Line, St Louis Veterans Administration Medical Center, U S Department of Veterans Affairs, St Louis, Missouri 63106, USA
    Hum Mutat 29:1133-40. 2008
    ..mutant protein is capable of dominant negative activity that results in ectopic activation of two downstream genes, Nppa and Shox2, in the developing heart and limb...
  95. doi Differential protein expression in heart in UT-B null mice with cardiac conduction defects
    Hao Yu
    Department of Pathophysiology, Research Center of Prostate Diseases, School of Basic Medicine, Jilin University, Changchun, P R China
    Proteomics 9:504-11. 2009
    ..UT-B null mice at early stage prior to the development of P-R interval elongation, while the change of atrial natriuretic peptide (ANP) occurred only at late stage in UT-B null mice that had the AV block...
  96. pmc Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5
    Ramón A Espinoza-Lewis
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Dev Biol 327:376-85. 2009
    ..Genetically, the lack of Tbx3 and Hcn4 expression, along with ectopic activation of Nppa, Cx40, and Nkx2-5 in the Shox2(-/-) SAN region, indicates a failure in SAN differentiation...
  97. doi Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression
    Irina I Nagy
    Department of Medical Biochemistry and Molecular Biology, University of Oulu, 90014 Oulu, Finland
    Cardiovasc Res 85:100-9. 2010
    ..We have addressed the potential role of Wnt-11 in the control of early ventricular myocardium assembly...
  98. pmc Hypertrophic gene expression induced by chronic stretch of excised mouse heart muscle
    Anna M Raskin
    Department of Bioengineering, University of California San Diego, CA 92093, USA
    Mol Cell Biomech 6:145-59. 2009
    ..The system was able to measure the induction of hypertrophic markers (BNP, ANP) in tissue after 2 hrs and 5 hrs of stretch...
  99. pmc Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development
    Nicola J A Scott
    Department of Medicine, University of Otago Christchurch, P O Box 4345, Christchurch, New Zealand
    Biochim Biophys Acta 1792:1175-84. 2009
    ..and an induction of a panel of genes normally expressed in the embryonic and neonatal ventricle, such as atrial natriuretic peptide (ANP)...
  100. pmc ANP-mediated inhibition of distal nephron fractional sodium reabsorption in wild-type and mice overexpressing natriuretic peptide receptor
    Di Zhao
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center School of Medicine, New Orleans, Louisiana 70112, USA
    Am J Physiol Renal Physiol 298:F103-8. 2010
    b>Atrial natriuretic peptide (ANP) elicits natriuresis; however, the relative contributions of proximal and distal nephron segments to the overall ANP-induced natriuresis have remained uncertain...
  101. pmc Atrial natriuretic peptide reduces vascular leakage and choroidal neovascularization
    Nuria Lara-Castillo
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 175:2343-50. 2009
    b>Atrial natriuretic peptide (ANP) is a hormone with diuretic, natriuretic, and vasodilatory properties...

Research Grants4

  1. Estrogen in pathogenesis of tubulointerstitial disease
    Christine Maric; Fiscal Year: 2003
    ..abstract_text> ..
  2. HAND GENES IN CARDIAC DEVELOPMENT
    William Pu; Fiscal Year: 2004
    ..This experience, and the information generated in this plan, will launch the applicant's career as an independent investigator. ..
  3. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2008
    ..abstract_text> ..
  4. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
    ..abstract_text> ..