Nr1h4

Summary

Gene Symbol: Nr1h4
Description: nuclear receptor subfamily 1, group H, member 4
Alias: AI957360, Fxr, HRR1, RIP14, Rxrip14, bile acid receptor, RXR-interacting protein 14, farnesoid X activated receptor, farnesol receptor HRR-1, retinoid X receptor-interacting protein 14
Species: mouse

Top Publications

  1. pmc Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine
    Ann M Thomas
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA
    Hepatology 51:1410-9. 2010
  2. ncbi Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    C J Sinal
    Laboratory of Metabolism, Division of Basic Sciences, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 102:731-44. 2000
  3. ncbi Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
    D Q Shih
    Laboratorie of Metabolic Diseases, The Rockefeller University, New York, New York, USA
    Nat Genet 27:375-82. 2001
  4. ncbi Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor
    Rajesh S Savkur
    Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Biochem Biophys Res Commun 329:391-6. 2005
  5. ncbi Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids
    Hanns Ulrich Marschall
    Karolinska Institutet, Department of Medicine at Karolinska University Hospital Huddinge, S 14186 Stockholm, Sweden
    J Lipid Res 47:582-92. 2006
  6. ncbi Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters
    Reid M Huber
    Department of Biotechnology, Bristol Myers Squibb Company, Experimental Station, Wilmington, DE 19880, USA
    Gene 290:35-43. 2002
  7. ncbi Repression of farnesoid X receptor during the acute phase response
    Min Sun Kim
    Department of Medicine, University of California San Francisco, Metabolism Section, Medical Service, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 278:8988-95. 2003
  8. ncbi Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein
    Tineke Kok
    Groningen University Institute for Drug Exploration, Center for Liver, Digestive, and Metabolic Diseases, University Hospital Groningen, CMC IV, Rm Y2 163, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Biol Chem 278:41930-7. 2003
  9. ncbi Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity
    Grace L Guo
    Laboratory of Metabolism, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45062-71. 2003
  10. ncbi Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
    Antonio Moschetta
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9050, USA
    Nat Med 10:1352-8. 2004

Research Grants

  1. Comparative Toxicogenomics Database
    James Boyer; Fiscal Year: 2004
  2. MECHANISMS OF BILE SECRETION AND CHOLESTASIS
    James Boyer; Fiscal Year: 2007
  3. CENTER FOR MEMBRANE TOXICITY STUDIES
    James Boyer; Fiscal Year: 2008
  4. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2008
  5. MOLECULAR REGULATION OF FXR ACTIVITY
    Jongsook Kim Kemper; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications117 found, 100 shown here

  1. pmc Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine
    Ann M Thomas
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA
    Hepatology 51:1410-9. 2010
    Farnesoid X receptor (FXR) is a bile acid-activated transcription factor belonging to the nuclear receptor superfamily...
  2. ncbi Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    C J Sinal
    Laboratory of Metabolism, Division of Basic Sciences, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 102:731-44. 2000
    Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were outwardly identical to wild-type littermates...
  3. ncbi Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
    D Q Shih
    Laboratorie of Metabolic Diseases, The Rockefeller University, New York, New York, USA
    Nat Genet 27:375-82. 2001
    ..The Tcf1 protein (also known as HNF-1alpha) also regulates transcription of the gene (Nr1h4) encoding the farnesoid X receptor-1 (Fxr-1), thereby leading to reduced expression of small heterodimer partner-1 ..
  4. ncbi Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor
    Rajesh S Savkur
    Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Biochem Biophys Res Commun 329:391-6. 2005
    ..We demonstrate that the farnesoid X receptor (FXR; NR1H4), which regulates a variety of genes involved in lipoprotein metabolism, also regulates the expression of PDK4...
  5. ncbi Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids
    Hanns Ulrich Marschall
    Karolinska Institutet, Department of Medicine at Karolinska University Hospital Huddinge, S 14186 Stockholm, Sweden
    J Lipid Res 47:582-92. 2006
    Farnesoid X receptor knockout (Fxr(-/-)) mice cannot upregulate the bile salt export pump in bile acid loading or cholestatic conditions...
  6. ncbi Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters
    Reid M Huber
    Department of Biotechnology, Bristol Myers Squibb Company, Experimental Station, Wilmington, DE 19880, USA
    Gene 290:35-43. 2002
    ..alpha (NR1H3), while feedback regulation is provided by bile acids through farnesoid-X-receptor (FXR) (NR1H4). The Syrian golden hamster provides a useful model for studying lipid metabolism...
  7. ncbi Repression of farnesoid X receptor during the acute phase response
    Min Sun Kim
    Department of Medicine, University of California San Francisco, Metabolism Section, Medical Service, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 278:8988-95. 2003
    ..In the present study, we show that LPS significantly decreases farnesoid X receptor (FXR) mRNA in mouse liver as early as 8 h after LPS administration, and this decrease was dose-dependent with the half-..
  8. ncbi Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein
    Tineke Kok
    Groningen University Institute for Drug Exploration, Center for Liver, Digestive, and Metabolic Diseases, University Hospital Groningen, CMC IV, Rm Y2 163, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Biol Chem 278:41930-7. 2003
    The bile salt-activated farnesoid X receptor (FXR; NR1H4) controls expression of several genes considered crucial in maintenance of bile salt homeostasis...
  9. ncbi Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity
    Grace L Guo
    Laboratory of Metabolism, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45062-71. 2003
    The nuclear receptors, farnesoid X receptor (FXR) and pregnane X receptor (PXR), are important in maintaining bile acid homeostasis...
  10. ncbi Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
    Antonio Moschetta
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9050, USA
    Nat Med 10:1352-8. 2004
    ..Here, we describe the same phenotype in mice lacking the bile acid receptor, FXR...
  11. ncbi Regulation of carbohydrate metabolism by the farnesoid X receptor
    Keith R Stayrook
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    Endocrinology 146:984-91. 2005
    The farnesoid X receptor (FXR; NR1H4) is a nuclear hormone receptor that functions as the bile acid receptor. In addition to the critical role FXR plays in bile acid metabolism and transport, it regulates a variety of genes important in ..
  12. ncbi Transient impairment of the adaptive response to fasting in FXR-deficient mice
    Bertrand Cariou
    Research Unit 545 INSERM, Atherosclerosis Department, Pasteur Institute of Lille, Faculty of Pharmacy, Lille2 University, Lille, France
    FEBS Lett 579:4076-80. 2005
    The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR-/-) and wild-type mice were submitted to fasting for 48 h...
  13. ncbi The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice
    Bertrand Cariou
    Institut Pasteur de Lille, Departement d Atherosclerose, Lille, F 59019, France
    J Biol Chem 281:11039-49. 2006
    The farnesoid X receptor (FXR) is a bile acid (BA)-activated nuclear receptor that plays a major role in the regulation of BA and lipid metabolism...
  14. pmc Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 103:3920-5. 2006
    ..Here we show that the farnesoid X receptor (FXR), a nuclear receptor for bile acids, induces genes involved in enteroprotection and inhibits bacterial overgrowth ..
  15. pmc Farnesoid X receptor is essential for normal glucose homeostasis
    Ke Ma
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    J Clin Invest 116:1102-9. 2006
    The bile acid receptor farnesoid X receptor (FXR; NR1H4) is a central regulator of bile acid and lipid metabolism. We show here that FXR plays a key regulatory role in glucose homeostasis...
  16. ncbi Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
    Wendong Huang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Science 312:233-6. 2006
    ..regeneration, and decreased levels inhibit liver regrowth, as does the absence of the primary nuclear bile acid receptor FXR...
  17. ncbi The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo
    Giovanni Rizzo
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Via E dal Pozzo, 06122 Perugia, Italy
    Mol Pharmacol 70:1164-73. 2006
    ..In this study, we have investigated the role of the farnesoid X receptor (FXR), a bile acid-activated nuclear receptor, in regulating adipogenesis in a preadipocyte cell line (3T3-L1 cells)...
  18. ncbi FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice
    Yanqiao Zhang
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 26:2316-21. 2006
    Based on the observation that Fxr-/- mice exhibit a proatherogenic lipoprotein profile, we investigated the role of FXR in the development of atherosclerosis.
  19. pmc Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
    Insook Kim
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:940-6. 2007
    The farnesoid X receptor (FXR) controls the synthesis and transport of bile acids (BAs). Mice lacking expression of FXR, designated Fxr-null, have elevated levels of serum and hepatic BAs and an increase in BA pool size...
  20. ncbi Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor
    Fan Yang
    Department of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Cancer Res 67:863-7. 2007
    Farnesoid X receptor (FXR, NR1H4) is a member of the nuclear hormone receptor superfamily, which plays an essential role in regulating bile acid, lipid, and glucose homeostasis...
  21. ncbi Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy
    Tao Jiang
    Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, 4200 East 9th Ave, Denver, CO 80262, USA
    Diabetes 56:2485-93. 2007
    ..Farnesoid X receptor (FXR) is a member of the nuclear hormone receptor superfamily...
  22. ncbi Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
    Insook Kim
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 48:2664-72. 2007
    ..acid concentrations are controlled by a feedback regulatory pathway whereby activation of the farnesoid X receptor (FXR) represses transcription of both the CYP7A1 gene, encoding the rate-limiting enzyme in the classic bile acid ..
  23. ncbi Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans
    Peter Kovacs
    University of Leipzig, Department of Medicine III, Leipzig, Germany
    J Hepatol 48:116-24. 2008
    From quantitative trait locus mapping in inbred mice, we identified the Nr1h4 gene encoding the nuclear bile salt receptor FXR as a candidate gene for the cholesterol gallstone susceptibility locus Lith7...
  24. ncbi Immunolocalization of farnesoid X receptor (FXR) in mouse tissues using tissue microarray
    Hiroyuki Higashiyama
    Tsukuba Research Laboratories, Pharmacology Department, GlaxoSmithKline, 43 Wadai, Tsukuba, Ibaraki 300 4247, Japan
    Acta Histochem 110:86-93. 2008
    Farnesoid X receptor (FXR) is a member of the nuclear receptor family and is known to play important roles in bile acid homeostasis, and lipid and glucose metabolism...
  25. pmc Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet
    Bo Kong
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 328:116-22. 2009
    ..knockout (LDLr(-/-)) mice fed a high-fat diet for 5 months, to test the hypothesis that farnesoid X receptor (FXR) deficiency contributed to NASH development...
  26. pmc Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response
    Yan Dong Wang
    Department of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA
    Hepatology 48:1632-43. 2008
    The farnesoid X receptor (FXR) is a nuclear receptor that plays key roles in hepatoprotection by maintaining the homeostasis of liver metabolism. FXR null mice display strong hepatic inflammation and develop spontaneous liver tumors...
  27. doi Antiatherosclerotic effect of farnesoid X receptor
    Andrea Mencarelli
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Perugia, Italy
    Am J Physiol Heart Circ Physiol 296:H272-81. 2009
    The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that functions as an endogenous sensor for bile acids and regulates cholesterol and fatty acid metabolism...
  28. pmc An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/- mice
    Theo H van Dijk
    Departments of Laboratory Medicine and Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    J Biol Chem 284:10315-23. 2009
    The farnesoid X receptor (FXR) is involved in regulation of bile acid and lipid metabolism. Recently, a role for FXR in control of glucose metabolism became evident...
  29. pmc The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria
    Xiaoxin X Wang
    Department of Medicine, University of Colorado Denver, and Veterans Affairs Medical Center, Aurora, Colorado, USA
    Am J Physiol Renal Physiol 297:F1587-96. 2009
    ..In the current study, we have determined a key role of the farnesoid X receptor (FXR) in modulating renal SREBP-1 activity, glomerular lesions, and proteinuria...
  30. doi The bile acid receptor FXR is a modulator of intestinal innate immunity
    Piero Vavassori
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Perugia, Italy
    J Immunol 183:6251-61. 2009
    The farnesoid X receptor (FXR) is a bile acid-regulated nuclear receptor expressed in enterohepatic tissues...
  31. pmc Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia
    Yanqiao Zhang
    Department of Integrative Medical Sciences, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272, USA
    J Biol Chem 285:3035-43. 2010
    Farnesoid X receptor (FXR) plays important regulatory roles in bile acid, lipoprotein, and glucose homeostasis...
  32. doi The bile acid sensor FXR regulates insulin transcription and secretion
    Barbara Renga
    Department of Experimental and Clinical Medicine, University of Perugia, Perugia, Italy
    Biochim Biophys Acta 1802:363-72. 2010
    ..Here we investigated whether FXR is expressed by pancreatic beta-cells and regulates insulin signaling in pancreatic beta-cell line and human islets...
  33. pmc FXR regulates liver repair after CCl4-induced toxic injury
    Zhipeng Meng
    Department of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, California 91010, USA
    Mol Endocrinol 24:886-97. 2010
    ..Farnesoid X receptor (FXR, NR1H4) is an emerging liver metabolic regulator and cell protector...
  34. pmc Regulation of bile acid synthesis by fat-soluble vitamins A and D
    Daniel R Schmidt
    Department of Pharmacology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9050, USA
    J Biol Chem 285:14486-94. 2010
    ..These results reveal an unexpected link between the intake of fat-soluble vitamins A and D and bile acid metabolism, which may have evolved as a means for these dietary vitamins to regulate their own absorption...
  35. doi The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity
    Iuliana Ristea Popescu
    University Lille Nord de France, Lille, France
    FEBS Lett 584:2845-51. 2010
    Farnesoid X receptor (FXR) is highly expressed in liver and intestine where it controls bile acid (BA), lipid and glucose homeostasis...
  36. pmc Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model
    Xiaoxin X Wang
    Department of Medicine, University of Colorado Denver, and VA Medical Center, Aurora, Colorado, USA
    Diabetes 59:2916-27. 2010
    ..Our previous studies have shown that the farnesoid X receptor (FXR), a bile acid-activated nuclear hormone receptor, modulates renal SREBP-1 expression...
  37. pmc The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma and interfering with the Wnt/beta-catenin pathways
    Mouaadh Abdelkarim
    Universite Lille Nord de France, F 59000 Lille, France
    J Biol Chem 285:36759-67. 2010
    The bile acid receptor farnesoid X receptor (FXR) is expressed in adipose tissue, but its function remains poorly defined...
  38. doi Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
    Raffaella M Gadaleta
    Department of Gastroenterology and Hepatology, UMC Utrecht, The Netherlands
    Gut 60:463-72. 2011
    ..The bile salt, nuclear farnesoid X receptor (FXR), was recently implicated in intestinal antibacterial defence and barrier function...
  39. doi Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter
    Barbara Renga
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Via E dal Pozzo, 06122 Perugia, Italy
    Biochim Biophys Acta 1809:157-65. 2011
    ..In this study we demonstrate that farnesoid X receptor (FXR) regulates MRP4 in vivo and in vitro. In vivo deletion of FXR induces MRP4 gene expression...
  40. pmc Increased activation of the Wnt/β-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice
    Andy Wolfe
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas Life Sciences Innovation Center 4087, Mail Stop 1018, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 338:12-21. 2011
    Farnesoid X receptor (FXR), the primary bile acid-sensing nuclear receptor, also is known for its anticancer properties...
  41. doi Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage
    Fan Lian
    Department of Gastroenterology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Biochem J 438:315-23. 2011
    ..FXR (farnesoid X receptor/NR1H4) is a transcription factor regulated by bile acids such as CDCA (chenodeoxycholic acid)...
  42. doi Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis
    Salvatore Modica
    Laboratory of Lipid Metabolism and Cancer, Department of Translational Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Gastroenterology 142:355-65.e1-4. 2012
    ..The farnesoid X receptor (FXR) is the transcriptional regulator of BA homeostasis...
  43. pmc Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice
    Yanqiao Zhang
    Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio 44272, USA
    Mol Endocrinol 26:272-80. 2012
    Farnesoid X receptor (FXR) is known to play important regulatory roles in bile acid, lipid, and carbohydrate metabolism. Aged (>12 months old) Fxr(-/-) mice also develop spontaneous liver carcinomas...
  44. doi Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition
    Barbara Renga
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Via E dal Pozzo, 06122 Perugia, Italy
    FASEB J 26:3021-31. 2012
    ..Here, we report that the farnesoid X receptor (FXR), a bile acid sensor, activates gluconeogenic pathways in the liver and regulates GR expression and activity...
  45. pmc Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression
    Nian Liu
    Division of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA
    Mol Endocrinol 26:775-85. 2012
    Farnesoid X receptor (FXR) (nuclear receptor subfamily 1, group H, member 4) is a member of nuclear hormone receptor superfamily, which plays essential roles in metabolism of bile acids, lipid, and glucose...
  46. pmc Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding
    Guodong Li
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 7:e35895. 2012
    Farnesoid X receptor (FXR) is a nuclear receptor and a key regulator of liver cholesterol and triglyceride homeostasis...
  47. doi Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
    Fei Li
    1 Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA 2
    Nat Commun 4:2384. 2013
    ..T-β-MCA is an farnesoid X receptor (FXR) nuclear receptor antagonist, which is involved in the regulation of bile acid, lipid and glucose metabolism...
  48. ncbi Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation
    Yanqiao Zhang
    Department of Biological Chemistry, University of California, Los Angeles, California 90095, USA
    J Biol Chem 278:104-10. 2003
    The Farnesoid X receptor (FXR) is a member of the nuclear hormone receptor superfamily that has been shown to play an important role in bile acid and cholesterol homeostasis...
  49. ncbi The farnesoid X-receptor is an essential regulator of cholesterol homeostasis
    Gilles Lambert
    Molecular Disease Branch, NHLBI, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    J Biol Chem 278:2563-70. 2003
    To address the importance of the farnesoid X-receptor (FXR; NR1H4) for normal cholesterol homeostasis, we evaluated the major pathways of cholesterol metabolism in the FXR-deficient (-/-) mouse model...
  50. ncbi Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression
    Thierry Claudel
    UR545 INSERM, Departement d Atherosclerose, Institut Pasteur de Lille, Lille, France
    Gastroenterology 125:544-55. 2003
    ..Apolipoprotein CIII (Apo CIII) is a determinant of serum triglyceride metabolism. In this study, we investigated whether activators of the nuclear farnesoid X receptor (FXR) modulate Apo CIII gene expression.
  51. pmc Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR
    Yanqiao Zhang
    Department of Biological Chemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Genes Dev 18:157-69. 2004
    ..Here we show that PGC-1alpha regulates triglyceride metabolism through both farnesoid X receptor (FXR)-dependent and -independent pathways...
  52. ncbi The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition
    Daniel Duran-Sandoval
    U R 545 INSERM, Atherosclerosis Department, Pasteur Institute of Lille and the Faculty of Pharmacy, Lille2 University, France
    J Biol Chem 280:29971-9. 2005
    ..The farnesoid X receptor (FXR) is a bile acid-activated nuclear receptor. Hepatic FXR expression is regulated by glucose and insulin...
  53. pmc Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
    Yanqiao Zhang
    Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:1006-11. 2006
    Farnesoid X receptor (FXR) plays an important role in maintaining bile acid and cholesterol homeostasis. Here we demonstrate that FXR also regulates glucose metabolism...
  54. doi Nuclear bile acid receptor FXR protects against intestinal tumorigenesis
    Salvatore Modica
    Laboratory of Lipid Metabolism and Cancer, Department of Translational Pharmacology, Consorzio Mario Negri Sud, Santa MariaImbaro, Chieti and Clinica Medica A Murri, University of Bari, Bari, Italy
    Cancer Res 68:9589-94. 2008
    ..have been considered intestinal tumor promoters, and because they are natural ligands for the nuclear receptor FXR, we examined the role of FXR in intestinal tumorigenesis...
  55. pmc Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells
    Stefania Catalano
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Italy
    J Biol Chem 285:5581-93. 2010
    The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that regulates bile acid homeostasis...
  56. pmc Farnesoid X receptor activation mediates head-to-tail chromatin looping in the Nr0b2 gene encoding small heterodimer partner
    Guodong Li
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mol Endocrinol 24:1404-12. 2010
    ..SHP is highly expressed in the liver, and previous studies have shown farnesoid X receptor (FXR) highly induces SHP by binding to a FXR response element (FXRRE) in the promoter of the Nr0b2 gene, which encodes ..
  57. pmc Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1
    Hansook Kim Chong
    Department of Molecular Biology and Biochemistry, Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA
    Nucleic Acids Res 38:6007-17. 2010
    We used mouse hepatic chromatin enriched with an FXR antibody and chromatin immunoprecipitation-sequencing (ChIP-seq) to evaluate FXR binding on a genome-wide scale...
  58. pmc Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity
    Janne Prawitt
    University of Lille Nord de France, Inserm UMR1011, UDSL, Institut Pasteur de Lille, Lille, France
    Diabetes 60:1861-71. 2011
    ..The nuclear BA receptor farnesoid X receptor (FXR) regulates pathways in BA, lipid, glucose, and energy metabolism, which become dysregulated in obesity...
  59. pmc Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition
    Martina Dufer
    Department of Pharmacology, Institute of Pharmacy, University of Tubingen, Tubingen, Germany
    Diabetes 61:1479-89. 2012
    ..Experiments were performed with islets from wild-type, farnesoid X receptor (FXR) knockout (KO), and β-cell ATP-dependent K(+) (K(ATP)) channel gene SUR1 (ABCC8) KO mice, respectively...
  60. doi Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
    Sama I Sayin
    Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg, 413 45 Gothenburg, Sweden
    Cell Metab 17:225-35. 2013
    ..acid synthesis is under negative feedback control through activation of the nuclear receptor farnesoid X receptor (FXR) in the ileum and liver...
  61. ncbi Regulation of hepatic Insig-2 by the farnesoid X receptor
    Melissa L Hubbert
    Department of Biological Chemistry, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    Mol Endocrinol 21:1359-69. 2007
    ..Together, these changes likely account for the decrease in cholesterol synthesis observed after activation of FXR in primary hepatocytes...
  62. pmc Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease
    Lihua Jin
    State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Fujian 361005, China
    Sci Rep 5:17288. 2015
    ..Farnesoid X receptor (FXR) is an ideal target for NAFLD drug development due to its crucial roles in lipid metabolism...
  63. doi Activation of farnesoid X receptor attenuates liver injury in systemic lupus erythematosus
    Fan Lian
    Department of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Rheumatol Int 32:1705-10. 2012
    To investigate the expression and effect of farnesoid X receptor (FXR) on systemic lupus erythematosus (SLE) liver dysfunction and indicate its hepatoprotective role and the immunomodulatory property...
  64. doi The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate
    Barbara Renga
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Italy
    Biochim Biophys Acta 1812:1522-31. 2011
    ..The Farnesoid X Receptor (FXR) is a bile acid sensor in hepatocytes...
  65. pmc Tissue specific induction of p62/Sqstm1 by farnesoid X receptor
    Jessica A Williams
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 7:e43961. 2012
    Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily and is a ligand-activated transcription factor essential for maintaining liver and intestinal homeostasis...
  66. pmc Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer
    Yanjun Jiang
    Department of Pathology and Immunology, Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Hepatology 57:1098-106. 2013
    ..We found that farnesoid X receptor (FXR) inhibits expression of gankyrin in quiescent livers by silencing the gankyrin promoter through HDAC1-C/EBPβ ..
  67. doi FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress
    Makoto Shimizu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo, Tokyo 113 8657, Japan
    Biochem J 450:221-9. 2013
    ..Overexpression of ATF4 in Caco-2 cells induced increased FGF19 mRNA expression, whereas shRNA (short hairpin RNA)-mediated depletion of ATF4 significantly attenuated a thapsigargin-induced increase in FGF19 mRNA...
  68. ncbi Genetic mapping of gene encoding the farnesoid receptor, Fxr, to mouse Chromosome 10
    C A Kozak
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    Mamm Genome 7:164-5. 1996
  69. ncbi FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice
    Henning Wittenburg
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Gastroenterology 125:868-81. 2003
    ..Cholesterol gallstone formation is a complex genetic trait. To identify additional cholesterol gallstone susceptibility loci, we performed a quantitative trait locus analysis using an intercross of PERA/Ei and I/LnJ inbred strains of mice...
  70. ncbi Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver
    Steven P Anderson
    Investigative Toxicology and Pathology Group, Safety Assessment, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, USA
    Mol Pharmacol 66:1440-52. 2004
    ....
  71. ncbi Regulation of drug transporters by the farnesoid X receptor in mice
    Tomoji Maeda
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan
    Mol Pharm 1:281-9. 2004
    The farnesoid X receptor (FXR, NR1H4) regulates bile acid and lipid homeostasis by acting as an intracellular bile acid-sensing transcription factor, resulting in altered expression of enzymes and transporters involved in bile acid ..
  72. ncbi Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver
    Gernot Zollner
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Graz, Austria
    Am J Physiol Gastrointest Liver Physiol 289:G798-805. 2005
    ..Bile acid-induced, farnesoid X receptor (FXR)-mediated induction of the nuclear repressor short heterodimer partner (SHP) has been proposed as a key mechanism ..
  73. ncbi Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice
    Elyisha A Hanniman
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Lipid Res 46:2595-604. 2005
    The farnesoid X receptor (FXR) is a bile acid-activated transcription factor that regulates the expression of genes critical for bile acid and lipid homeostasis...
  74. ncbi Gallbladder histopathology during murine gallstone formation: relation to motility and concentrating function
    Karel J van Erpecum
    Department of Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Lipid Res 47:32-41. 2006
    ..additional experiments, similar downregulation of AQP1 and AQP8 mRNA expression occurred in farnesoid X receptor (FXR)-deficient mice after 1 week on the lithogenic diet, without any difference from corresponding wild-type mice...
  75. ncbi FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine
    Hans Lee
    Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 47:201-14. 2006
    Expression of the farnesoid X receptor (FXR; NR1H4) is limited to the liver, intestine, kidney, and adrenal gland. However, the role of FXR in the latter two organs is unknown...
  76. ncbi A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids
    Diana M Shih
    Division of Cardiology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 47:384-92. 2006
    ..In the current study, we used wild-type and farnesoid X receptor (FXR) null mice to demonstrate that this repression is dependent upon CA and FXR...
  77. ncbi Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4
    Alejandra Gutierrez
    Department of Biology and Heart Institute, San Diego State University, San Diego, CA 92182, USA
    Arterioscler Thromb Vasc Biol 26:301-6. 2006
    ..The purpose of this research was to determine how dietary bile acids repress hepatic expression of paraoxonase 1 (PON1)...
  78. pmc Plasticity and expanding complexity of the hepatic transcription factor network during liver development
    Irene Kyrmizi
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, 711 10 Herakleion, Crete, Greece
    Genes Dev 20:2293-305. 2006
    ..The results illustrate the remarkable flexibility of a self-sustaining transcription factor network, built up by complex dominant and redundant regulatory motifs in developing hepatocytes...
  79. ncbi The expression profiles of nuclear receptors in the developing and adult kidney
    Jae Mi Suh
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 20:3412-20. 2006
    ..Our results suggest that these nuclear receptors are likely to play important physiological roles in the kidney development...
  80. pmc Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors
    Xingguo Cheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 106:29-36. 2008
    ..In conclusion, PFCAs increased Cyp2B10 and 4A14 expression by activating PPAR-alpha and CAR nuclear receptors, respectively. PPAR-alpha is activated at much lower doses of PFDA than CAR...
  81. pmc The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP
    Sungsoon Fang
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 283:35086-95. 2008
    The primary bile acid receptor farnesoid X receptor (FXR) maintains lipid and glucose homeostasis by regulating expression of numerous bile acid-responsive genes, including an orphan nuclear receptor and metabolic regulator SHP...
  82. pmc Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed farnesoid X receptor (FXR)-null mice: FXR-independent suppression of intestinal bile acid absorption
    Masaaki Miyata
    Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3, Aoba, Aramaki, Aoba ku, Sendai, 980 8578, Japan
    Drug Metab Dispos 37:338-44. 2009
    Cholic acid (CA) feeding of farnesoid X receptor (Fxr)-null mice results in markedly elevated hepatic bile acid levels and liver injury...
  83. doi Suppression of interleukin-6-induced C-reactive protein expression by FXR agonists
    Songwen Zhang
    Department of Cardiovascular and Metabolic Diseases Research, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Biochem Biophys Res Commun 379:476-9. 2009
    ..The farnesoid X receptor (FXR), a member of the nuclear hormone receptor superfamily, plays an essential role in the regulation of enterohepatic ..
  84. pmc ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity
    Dae Hwan Kim
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 23:1556-62. 2009
    ..LxxLL motif of ASC-2 shows relatively weak but specific interaction with the nuclear receptor farnesoid X receptor (FXR) and that ASCOM plays crucial roles in FXR transactivation...
  85. pmc Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis
    Ji Miao
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Mol Cell Biol 29:6170-81. 2009
    ..is critical in maintaining health and is primarily regulated by the nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner (SHP)...
  86. doi The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis
    Andrea Mencarelli
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Perugia, Italy
    J Immunol 183:6657-66. 2009
    ..In this study, we report that activation of the farnesoid X receptor (FXR), a member of the ligand-activated nuclear receptor superfamily and bile sensor highly expressed in the liver, ..
  87. pmc FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
    Jongsook Kim Kemper
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
    Cell Metab 10:392-404. 2009
    The nuclear bile acid receptor FXR is critical for regulation of lipid and glucose metabolism. Here, we report that FXR is a target of SIRT1, a deacetylase that mediates nutritional and hormonal modulation of hepatic metabolism...
  88. pmc Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts
    Peter Fickert
    Laboratory of Experimental and Molecular Hepatology, Medical University Graz, Graz, Austria
    Am J Pathol 175:2392-405. 2009
    The nuclear bile acid receptor, farnesoid X receptor (FXR), may play a pivotal role in liver fibrosis. We tested the impact of genetic FXR ablation in four different mouse models...
  89. pmc Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge
    Joo Youn Cho
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 51:1063-74. 2010
    Farnesoid X receptor (FXR) is a nuclear receptor that regulates genes involved in synthesis, metabolism, and transport of bile acids and thus plays a major role in maintaining bile acid homeostasis...
  90. pmc A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition
    Jiyoung Lee
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana Champaign, Illinois 61801, USA
    J Biol Chem 285:12604-11. 2010
    ..Here, we report that the nuclear bile acid receptor farnesoid X receptor (FXR) inhibits microRNA-34a (miR-34a) in the liver, which results in a positive ..
  91. doi Effects of farnesoid X receptor on the expression of the fatty acid synthetase and hepatic lipase
    Li Li Shen
    Department of Biochemistry and Molecular Biology, The Third Military Medical University, Chongqing, 400038, China
    Mol Biol Rep 38:553-9. 2011
    The farnesoid X receptor (FXR) is a nuclear receptor that regulates gene expression in response to bile acids (BAs). FXR plays an important role in the homeostasis of bile acid, cholesterol, lipoprotein and triglyceride...
  92. pmc Nuclear receptors in Leydig cell gene expression and function
    Luc J Martin
    Reproduction, Perinatal, and Child Health, Research Centre du Centre Universitaire de Québec, Quebec City, Quebec, Canada
    Biol Reprod 83:3-14. 2010
    ..This review provides an overview of the nuclear receptor family of transcription factors as they relate to Leydig cell gene expression and function...
  93. pmc AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids
    Daniel R Schmidt
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 286:2425-32. 2011
    ..The farnesoid X receptor (FXR), which is activated by bile acids and abundantly expressed in enterohepatic tissues, plays a crucial role in ..
  94. pmc Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis
    Xuemei Ge
    Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA
    J Lipid Res 52:1561-8. 2011
    ..In this article, we show that activation of the nuclear receptor farnesoid X receptor (FXR) induces AKR1B7 expression in the liver and intestine, and reduces the levels of malondialdehyde (MDA), the end ..
  95. ncbi Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors
    W Seol
    Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Mol Endocrinol 9:72-85. 1995
    ..Of four additional RXR-interacting proteins (RIPs) selected for further study two, RIP14 and RIP15, are previously unidentified orphan members of the nuclear receptor superfamily...
  96. ncbi The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate
    Jisong Cui
    Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 277:25963-9. 2002
    ..differences, we analyzed the function of the ligand-binding domain (LBD) of human and murine farnesoid X receptor (FXR), a nuclear receptor for bile acids...
  97. pmc Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol
    Kerstin Otte
    LION bioscience AG, 69120 Heidelberg, Germany
    Mol Cell Biol 23:864-72. 2003
    ..Murine FXRbeta is widely coexpressed with FXR in embryonic and adult tissues...
  98. ncbi Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine
    Gernot Zollner
    Division of Gastroenterology and Hepatology, Department of Medicine, Karl Franzens University, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Hepatol 39:480-8. 2003
    ..Whether adaptive changes in ATP-binding cassette (ABC) transporter expression are stimulated by bile acids and their nuclear receptor FXR is unknown.
  99. ncbi Regulation of complement C3 expression by the bile acid receptor FXR
    Jiali Li
    Department of Biology, X Ceptor Therapeutics Inc, San Diego, California 92121, USA
    J Biol Chem 280:7427-34. 2005
    The farnesoid X receptor (FXR; NR1H4) is an intracellular bile acid-sensing transcription factor that plays a critical role in the regulation of synthesis and transport of bile acids as well as lipid metabolism...
  100. ncbi Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion
    Liqing Yu
    McDermott Center for Human Growth and Development, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 280:8742-7. 2005
    ..Cholate treatment was associated with a farnesoid X receptor (FXR)-dependent increase in hepatic mRNA and protein levels of G5 and G8...
  101. ncbi Pregnane X receptor is a target of farnesoid X receptor
    Diana Jung
    Division of Pharmacology and Neurobiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Biol Chem 281:19081-91. 2006
    ..Feeding mice with cholic acid or the synthetic farnesoid X receptor (FXR) agonist GW4064 resulted in a robust PXR induction. This effect was abolished in FXR knock-out mice...

Research Grants5

  1. Comparative Toxicogenomics Database
    James Boyer; Fiscal Year: 2004
    ..This project supports the rapid advances in DNA sequencing output by linking sequence data to other important biological and laboratory information and promoting collaboration among MFBS Centers and other participating scientists. ..
  2. MECHANISMS OF BILE SECRETION AND CHOLESTASIS
    James Boyer; Fiscal Year: 2007
    ..The effects of gender and estrogens on the role of these tethering proteins will also be compared in cyclic AMP mediated secretion in cholangiocytes. ..
  3. CENTER FOR MEMBRANE TOXICITY STUDIES
    James Boyer; Fiscal Year: 2008
    ..abstract_text> ..
  4. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2008
    ..Increased bile acids repress transcription of CYP7A1 by activating the FXR/SHP nuclear receptor cascade and by activating kinase signaling and fibroblast growth factor 15 signaling pathways ..
  5. MOLECULAR REGULATION OF FXR ACTIVITY
    Jongsook Kim Kemper; Fiscal Year: 2010
    The overall goal of this project is to understand molecular mechanisms by which the nuclear bile acid receptor, farnesoid X receptor (FXR), regulates metabolic homeostasis in normal and diseased states...