Olig2

Summary

Gene Symbol: Olig2
Description: oligodendrocyte transcription factor 2
Alias: AI604895, Bhlhb1, Olg-2, Oligo2, RK17, bHLHe19, oligodendrocyte transcription factor 2
Species: mouse

Top Publications

  1. ncbi Olig genes are expressed in a heterogeneous population of precursor cells in the developing spinal cord
    Ying Liu
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland 21224, USA
    Glia 45:67-74. 2004
  2. ncbi An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation
    Shu Zong Wang
    Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Development 133:3389-98. 2006
  3. pmc Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons
    David L Rousso
    Department of Neurobiology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuron 59:226-40. 2008
  4. ncbi Hedgehog signalling in the mouse requires intraflagellar transport proteins
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 426:83-7. 2003
  5. ncbi Characterization of progenitor domains in the developing mouse thalamus
    Tou Yia Vue
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Comp Neurol 505:73-91. 2007
  6. doi Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex
    Leda Dimou
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, 80336 Munich, Germany
    J Neurosci 28:10434-42. 2008
  7. ncbi Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    Q Richard Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 109:75-86. 2002
  8. pmc Development of NG2 neural progenitor cells requires Olig gene function
    Keith L Ligon
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:7853-8. 2006
  9. ncbi Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system
    Q R Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Neuron 25:317-29. 2000
  10. doi Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development
    C Francius
    Universite Catholique de Louvain, Institute of Neuroscience, Brussels, Belgium
    Neuroscience 165:116-29. 2010

Research Grants

  1. Development of Sensory maps in the Mammalian neocortex
    Yasushi Nakagawa; Fiscal Year: 2010
  2. Neurogenesis, Inflammation and Irradiation Injury
    MICHELLE MONJE DEISSEROTH; Fiscal Year: 2003
  3. Notch Signaling in Olfactory Progenitor Cell Fate
    TIMOTHY HENION; Fiscal Year: 2004
  4. Olig function in CNS development and tumorigenesis
    Keith Ligon; Fiscal Year: 2008
  5. PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINS
    Rashmi Bansal; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications144 found, 100 shown here

  1. ncbi Olig genes are expressed in a heterogeneous population of precursor cells in the developing spinal cord
    Ying Liu
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland 21224, USA
    Glia 45:67-74. 2004
    ..Here we show that Olig2 expression at early stages of development (prior to E16...
  2. ncbi An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation
    Shu Zong Wang
    Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Development 133:3389-98. 2006
    ..In addition, Zfp488 can interact and cooperate with the bHLH transcription factor Olig2 to promote precocious and ectopic oligodendrocyte differentiation...
  3. pmc Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons
    David L Rousso
    Department of Neurobiology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuron 59:226-40. 2008
    ....
  4. ncbi Hedgehog signalling in the mouse requires intraflagellar transport proteins
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 426:83-7. 2003
    ..Our data show that IFT machinery has an essential and vertebrate-specific role in Hedgehog signal transduction...
  5. ncbi Characterization of progenitor domains in the developing mouse thalamus
    Tou Yia Vue
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Comp Neurol 505:73-91. 2007
    ..pTH-C is composed of subdomains, we characterized expression of the homeodomain protein Dbx1 and the bHLH protein Olig2. We show that Dbx1 is expressed in caudodorsal-high to rostroventral-low gradient within pTH-C...
  6. doi Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex
    Leda Dimou
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, 80336 Munich, Germany
    J Neurosci 28:10434-42. 2008
    ..The majority of these progenitors express the basic-helix-loop-helix transcription factor Olig2, and their number further increases after injury...
  7. ncbi Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    Q Richard Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 109:75-86. 2002
    The oligodendrocyte lineage genes Olig1 and Olig2 encode related bHLH proteins that are coexpressed in neural progenitors...
  8. pmc Development of NG2 neural progenitor cells requires Olig gene function
    Keith L Ligon
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:7853-8. 2006
    ..Here, we show that >90% of embryonic and adult NG2 cells express Olig2, a basic helix-loop-helix transcription factor required for oligodendrocyte lineage specification...
  9. ncbi Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system
    Q R Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Neuron 25:317-29. 2000
    ..Gain- and loss-of-function analyses in transgenic mice demonstrate that Shh is both necessary and sufficient for Olg gene expression in vivo...
  10. doi Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development
    C Francius
    Universite Catholique de Louvain, Institute of Neuroscience, Brussels, Belgium
    Neuroscience 165:116-29. 2010
    ..Together, our data unveil a complex and dynamic expression profile of the OC proteins in spinal MN, which suggests that these factors may participate in regulatory networks that control different steps of motor neuron development...
  11. ncbi Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism
    Eric Dessaud
    Developmental Neurobiology, National Institute for Medical Research Mill Hill, London NW7 1AA, UK
    Nature 450:717-20. 2007
    ..Together, the data reveal a novel strategy for morphogen interpretation, in which the temporal adaptation of cells to a morphogen integrates the concentration and duration of a signal to control differential gene expression...
  12. pmc HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction
    Feng Ye
    Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, USA
    Nat Neurosci 12:829-38. 2009
    ..and nuclear translocation of beta-catenin, which negatively regulates oligodendrocyte development by repressing Olig2 expression...
  13. ncbi Regionalization and fate specification in neurospheres: the role of Olig2 and Pax6
    M A Hack
    Neuronal Specification, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    Mol Cell Neurosci 25:664-78. 2004
    ..factors present in telencephalic precursors upon growth factor exposure in neurosphere cultures while Olig1 and Olig2 expression was strongly up-regulated...
  14. ncbi Glial cells generate neurons: the role of the transcription factor Pax6
    Nico Heins
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, 82152, Planegg Martinsreid, Munich, Germany
    Nat Neurosci 5:308-15. 2002
    ..These results demonstrated an important role of Pax6 as intrinsic fate determinant of the neurogenic potential of glial cells...
  15. ncbi Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling
    Jun Cai
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Neuron 45:41-53. 2005
    ..The ventral generation of oligodendrocytes requires Nkx6-regulated expression of the bHLH gene Olig2 in this domain...
  16. ncbi Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain
    Anna Vallstedt
    Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Neuron 45:55-67. 2005
    ..from a ventral progenitor domain defined by expression of the oligodendrocyte-determining bHLH proteins Olig1 and Olig2. Here, we provide evidence that progenitors in the dorsal spinal cord and hindbrain also produce oligodendrocytes ..
  17. pmc Ultraconserved elements in the Olig2 promoter
    Christina T L Chen
    Department of Genetics, Washington University in St Louis School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 3:e3946. 2008
    ..is specified early in development by the expression of the basic-helix-loop-helix transcription factor Olig2 in the ventral region of the neural tube...
  18. ncbi Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube
    T Sun
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Curr Biol 11:1413-20. 2001
    ..One of these, Nkx2.2, is necessary and sufficient for the development of V3 interneurons...
  19. pmc A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
    Mark Wijgerde
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 16:2849-64. 2002
    ..Thus, Hh signaling is essential for organizing ventral cell pattern, possibly through the control of differential cell affinities...
  20. pmc Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells
    Soo Kyung Lee
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Genes Dev 19:282-94. 2005
    ..b>Olig2 is a bHLH-class transcription factor in pMN cells, but it has remained unclear how its transcriptional activity is ..
  21. ncbi A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool
    Marta G del Barrio
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 134:3427-36. 2007
    ....
  22. doi In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neurons
    Y Abe
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Chuo Ku, Niigata 951 8585, Japan
    Neuroscience 161:95-110. 2009
    ..and ErbB2 mRNAs was relatively high at the perinatal stage and frequently colocalized with mRNA for S100beta and Olig2, markers for immature astrocytes or oligodendrocyte precursors...
  23. ncbi Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors
    Q Zhou
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Neuron 25:331-43. 2000
    ..We have identified two bHLH factors, Oligo1 and Oligo2, that are specifically expressed in zones of neuroepithelium from which oligodendrocyte precursors emerge, as well ..
  24. ncbi Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3
    H Takebayashi
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Yoshida, Konoe cho, Sakyo ku, 606 8501, Kyoto, Japan
    Mech Dev 99:143-8. 2000
    ..Here, we describe a novel bHLH family consisting of three members, two of which (Olig1, Olig2) are expressed in a nervous tissue-specific manner, whereas the third, Olig3 is found mainly in non-neural tissues...
  25. ncbi Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon
    N Tekki-Kessaris
    Wolfson Institute for Biomedical Research, The Cruciform Building, University College London, Gower Street, London WC1E 6AE, UK
    Development 128:2545-54. 2001
    ..neuroepithelium that co-expresses mRNA encoding SHH, its receptor PTC1 (PTCH) and the transcription factors OLIG1, OLIG2 and SOX10...
  26. ncbi Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor
    Y Qi
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Development 128:2723-33. 2001
    ..Interestingly, absence of Nkx2.2 expression leads to a ventral expansion of the Olig1/Olig2 expression in neuroepithelial cells into the Nkx2...
  27. ncbi Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
    B G Novitch
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Neuron 31:773-89. 2001
    ..We show here that a bHLH protein, Olig2, is expressed selectively by motor neuron progenitors and has a key role in specifying the subtype identity and ..
  28. pmc Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
    C Claus Stolt
    Institut fur Biochemie, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    Genes Dev 16:165-70. 2002
    ..Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms...
  29. ncbi The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification
    Qiao Zhou
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 109:61-73. 2002
    OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the pMN domain of the spinal cord, which sequentially generates motoneurons and oligodendrocytes...
  30. ncbi Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube
    Hirohide Takebayashi
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Yoshida, Konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Mech Dev 113:169-74. 2002
    Olig family is a novel sub-family of basic helix-loop-helix transcription factors recently identified. Olig1 and Olig2 were first reported to promote oligodendrocyte differentiation, and later Olig2 was reported to be involved in ..
  31. ncbi The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages
    Hirohide Takebayashi
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Yoshida, Konoe cho, Sakyo ku, Japan
    Curr Biol 12:1157-63. 2002
    ..Olig1 and Olig2 are related basic helix-loop-helix factors induced by Shh in the ventral neural tube...
  32. pmc Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity
    Madelen Persson
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, S 171 77 Stockholm, Sweden
    Genes Dev 16:2865-78. 2002
    ..Together these data raise the possibility that Gli proteins act as common mediators integrating Shh signals, and other sources of positional information, to control patterning throughout the ventral neural tube...
  33. ncbi Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex
    Tao Sun
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:9547-56. 2003
    In developing neural tube, the basic helix-loop-helix (bHLH) transcription factor Olig2 interacts with the homeodomain transcription factor Nkx2.2 at two distinct stages...
  34. ncbi Negative regulatory effect of an oligodendrocytic bHLH factor OLIG2 on the astrocytic differentiation pathway
    S Fukuda
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan
    Cell Death Differ 11:196-202. 2004
    In the developing vertebrate nervous system, multipotent neural stem cells produce both neurons and glia. OLIG2 is a basic helix-loop-helix transcription factor that plays critical roles in oligodendrocyte and motor neuron development; ..
  35. ncbi Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor
    Rugao Liu
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Development 130:6221-31. 2003
    ..In Nkx6.1 mutant spinal cords, expression of Olig2 in the motoneuron progenitor domain is diminished, and the generation and differentiation of oligodendrocytes are ..
  36. ncbi All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004
    ..Therefore, in the spinal cord all Hh signaling is Gli dependent. Furthermore, a combination of Gli2 and Gli3 is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors...
  37. ncbi Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy
    C Claus Stolt
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 131:2349-58. 2004
    ..Resulting differences in protein amounts might be a main reason for the weaker impact of Sox8 on oligodendrocyte development and for unidirectional compensation of the Sox8 loss by Sox10...
  38. ncbi Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation
    Jayshree Samanta
    Northwestern University s Feinberg School of Medicine, Department of Neurology, Chicago, IL 60611, USA
    Development 131:4131-42. 2004
    ..ID4, and to a lesser extent ID2, complexed with the basic-helix-loop-helix transcription (bHLH) factors OLIG1 and OLIG2, which are required for the generation of OLs. By contrast, ID1 and ID3 did not complex with the OLIG proteins...
  39. ncbi Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1
    Juhee Jeong
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 132:143-54. 2005
    ..Furthermore, this feedback mechanism is crucial in generating a neural tube that contains appropriate numbers of all ventral and intermediate neuronal cell types...
  40. ncbi Oligodendrocyte development in the embryonic brain: the contribution of the plp lineage
    Barbara Le Bras
    Unité Mixte de Recherche INSERM U 711 and UPMC, Paris, France
    Int J Dev Biol 49:209-20. 2005
    ....
  41. pmc Cilia and Hedgehog responsiveness in the mouse
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:11325-30. 2005
    ....
  42. ncbi Combinatorial profiles of oligodendrocyte-selective classes of transcriptional regulators differentially modulate myelin basic protein gene expression
    Solen Gokhan
    Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 25:8311-21. 2005
    Recent studies suggest that specific neural basic helix-loop-helix (HLH; i.e., Olig1 and Olig2, Mash1), associated inhibitory HLH (i.e., Id2 and Id4), high-mobility group domain (i.e., Sox10), and homeodomain (i.e., Nkx2...
  43. pmc Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair
    Annalisa Buffo
    Institute for Stem Cell Research, National Research Center for Environment and Health, Neuherberg Munich, Germany
    Proc Natl Acad Sci U S A 102:18183-8. 2005
    ..Ngn2, was detected in the injured parenchyma, we observed a strong up-regulation of the bHLH transcription factor Olig2, but not Olig1, upon acute and chronic injury...
  44. ncbi A critical role for dorsal progenitors in cortical myelination
    Tao Yue
    Center for Developmental Biology, Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:1275-80. 2006
    ..of dorsal progenitors to cortical myelination, we ablated the basic helix-loop-helix transcription factor Olig2 in the developing dorsal telencephalon. In Olig2-ablated cortices, myelination is arrested at the progenitor stage...
  45. ncbi Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube
    Tao Sun
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Dev Biol 292:152-64. 2006
    Within the motoneuron precursor (pMN) domain of the developing spinal cord, the bHLH transcription factor, Olig2, plays critical roles in pattern formation and the generation of motor neuron and oligodendrocyte precursors...
  46. ncbi Involvement of the Olig2 transcription factor in cholinergic neuron development of the basal forebrain
    Miki Furusho
    Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies Sokendai, Okazaki, Aichi 444 8787, Japan
    Dev Biol 293:348-57. 2006
    ..Areas presumed to be sites of origin of cholinergic neurons are roughly demarcated by expression of Olig2, a basic helix-loop-helix transcription factor, which includes the medial ganglionic eminence, septal area, and ..
  47. ncbi Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells
    Noritaka Masahira
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8787, Japan
    Dev Biol 293:358-69. 2006
    ..The pMN domain is the site of expression of two basic helix-loop-helix transcription factors, Olig1 and Olig2, which are essential for motoneuron and oligodendrocyte development...
  48. ncbi SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function
    C Claus Stolt
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, D 91054 Erlangen, Germany
    Dev Cell 11:697-709. 2006
    ..Our studies reveal a complex regulatory network between different groups of Sox proteins that is essential for proper progression of oligodendrocyte development...
  49. ncbi Induction of oligodendrocyte differentiation by Olig2 and Sox10: evidence for reciprocal interactions and dosage-dependent mechanisms
    Zijing Liu
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Dev Biol 302:683-93. 2007
    ..In the developing mouse spinal cord, expression of Olig2, Sox10 and Nkx2.2 is sequentially up-regulated in cells of oligodendrocyte lineage...
  50. ncbi The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord
    Benjamin Deneen
    Division of Biology 216 76, California Institute of Technology, 1201 East California Boulevard, Pasadena, California 91125, USA
    Neuron 52:953-68. 2006
    ..At later stages, NFIA promotes migration and differentiation of astrocyte precursors, a function that is antagonized in oligodendrocyte precursors by Olig2.
  51. ncbi Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord
    Michiya Sugimori
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 134:1617-29. 2007
    ..Here, we provide evidence that the transcription factors Pax6, Olig2 and Nkx2...
  52. ncbi The graded response to Sonic Hedgehog depends on cilia architecture
    Tamara Caspary
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 12:767-78. 2007
    ..Thus, normal structure of the ciliary axoneme is required for the cell to translate different levels of Shh ligand into differential regulation of the Gli transcription factors that implement Hedgehog signals...
  53. ncbi Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors
    Goichi Miyoshi
    Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:7786-98. 2007
    ..We used an inducible form of Cre under the regulation of Olig2, a basic helix-loop-helix transcription factor highly expressed in neural progenitors of the MGE...
  54. pmc Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
    Nuria Flames
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 27:9682-95. 2007
    ..Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains...
  55. doi Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression
    Markus Finzsch
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 135:637-46. 2008
    ..We thus conclude that Sox9 and Sox10 are required in a functionally redundant manner in oligodendrocyte precursors for PDGF-dependent survival and migration...
  56. doi Ascl1 is required for oligodendrocyte development in the spinal cord
    Michiya Sugimori
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Development 135:1271-81. 2008
    ..In vitro culture studies demonstrate that the induction and maintenance of co-expression of Olig2 and Nkx2-2 in OLPs, and thyroid hormone-responsive induction of myelin proteins are impaired in Ascl1-/- mutants...
  57. pmc THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
    Pamela V Tran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 40:403-10. 2008
    ..Specifically, the aln mutation uncouples the roles of anterograde and retrograde transport in SHH signaling, suggesting that anterograde IFT is required for GLI activation and that retrograde IFT modulates this event...
  58. pmc Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS
    Stephen P J Fancy
    Institute for Regeneration Medicine, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 23:1571-85. 2009
    ..Evidence of Wnt pathway activity in human MS lesions suggests that its dysregulation might contribute to inefficient myelin repair in human neurological disorders...
  59. doi The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling
    Helen Oi Lam Cheung
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Sci Signal 2:ra29. 2009
    ..Thus, Kif7 is a missing component of the mammalian Hh signaling machinery, implying a greater commonality between the Drosophila and mammalian system than the prevailing view suggests...
  60. doi The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development
    Setsu Endoh-Yamagami
    Department of Molecular Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Curr Biol 19:1320-6. 2009
    ..These results suggest a role for Kif7 in coordinating Hh signal transduction at the tip of cilia and preventing Gli3 cleavage into a repressor form in the presence of Hh...
  61. pmc Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination
    Yueting Zhang
    Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 106:19162-7. 2009
    ..These data suggest that Notch1 signaling is one of the mechanisms regulating OPC differentiation during CNS remyelination. Thus, Notch1 may represent a potential therapeutical avenue for lesion repair in demyelinating disease...
  62. pmc Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon
    Emmanuelle Huillard
    INSERM, U873, CEA, iRTSV LTS, 17 Av des Martyrs, F 38054 Grenoble, France
    Mol Cell Biol 30:2737-49. 2010
    ..We show that CK2beta directly interacts with the basic helix-loop-helix (bHLH) transcription factor Olig2, a critical modulator of OPC development, and activates the CK2-dependent phosphorylation of its serine-threonine-..
  63. pmc Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors
    Chengbing Wang
    Department of Genetic Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Development 137:2001-9. 2010
    ..Our study provides a new insight into the regulation of Gli2 and Gli3 stability and processing by Sufu and Spop, and reveals the unexpected Sufu-independent Gli3 repressor function...
  64. pmc Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog
    Eric Dessaud
    Developmental Neurobiology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS Biol 8:e1000382. 2010
    ..This suggests an alternative to conventional models of morphogen action that rely solely on the level of signalling...
  65. pmc MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord
    Kang Zheng
    College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China
    J Neurosci 30:8245-50. 2010
    ..By contrast, the early patterning and development of motor neurons were not affected in the mutant spinal cord tissue...
  66. pmc CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination
    Malgorzata Zawadzka
    MRC Cambridge Centre for Stem Cell Biology and Regenerative Medicine, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Cell Stem Cell 6:578-90. 2010
    ....
  67. pmc Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome
    Lina Chakrabarti
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC, USA
    Nat Neurosci 13:927-34. 2010
    ..We discovered that Olig1 and Olig2, two genes that are triplicated in Down syndrome and in Ts65Dn mice, were overexpressed in the Ts65Dn forebrain...
  68. pmc The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development
    Daniela C Thein
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, Erlangen, Germany
    J Neurochem 115:131-41. 2010
    ..We therefore conclude that the two Sox proteins directly function as pro-survival factors during spinal cord development in neural cell types...
  69. doi A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning
    Madelen Lek
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    Development 137:4051-60. 2010
    ..These data establish that dynamic, non-graded changes in responding cells are essential for Shh morphogen interpretation, and provide a rationale to explain mechanistically the phenomenon of cellular memory of morphogen exposure...
  70. pmc Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop
    Jun An Chen
    Departments of Pathology and Cell Biology, Neurology, and Neuroscience, Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 69:721-35. 2011
    ..motor neurons (pMN) and V2 interneurons (p2) are specified by a pair of cross-repressive transcription factors, Olig2 and Irx3...
  71. pmc Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb
    Rosa Eva Huettl
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Biol 9:e1001020. 2011
    ..Thus, motor and sensory axons are mutually dependent on each other for the generation of their trajectories and interact in part through Npn-1-mediated fasciculation before and within the plexus region of the limbs...
  72. pmc Phosphorylation regulates OLIG2 cofactor choice and the motor neuron-oligodendrocyte fate switch
    HuiLiang Li
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Neuron 69:918-29. 2011
    ..We asked how transcription factor OLIG2 participates in this MN-OLP fate switch...
  73. pmc Complex interactions between genes controlling trafficking in primary cilia
    Polloneal Jymmiel R Ocbina
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, USA
    Nat Genet 43:547-53. 2011
    ....
  74. doi Cranial nerve fasciculation and Schwann cell migration are impaired after loss of Npn-1
    Rosa Eva Huettl
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg
    Dev Biol 359:230-41. 2011
    ..Thus, initial hypoglossal nerve assembly and fasciculation, but not later guidance decisions depend on Npn-1 expression and axon-Schwann cell interactions...
  75. pmc Patterns of spinal sensory-motor connectivity prescribed by a dorsoventral positional template
    Gülşen Sürmeli
    Kavli Institute for Brain Science, Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Cell 147:653-65. 2011
    ..By implication, the clustering and dorsoventral settling position of motor neuron pools serve as a determinant of the pattern of sensory input specificity and thus motor coordination...
  76. pmc Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube
    Nikolaos Balaskas
    Developmental Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Cell 148:273-84. 2012
    ..Our findings reveal that morphogen interpretation is an emergent property of the architecture of a transcriptional network that provides robustness and reliability to tissue patterning...
  77. pmc Apoptosis of limb innervating motor neurons and erosion of motor pool identity upon lineage specific dicer inactivation
    Jun An Chen
    Departments of Pathology and Cell Biology, Neurology, and Neuroscience, Center for Motor Neuron Biology and Disease, Columbia University Medical Center New York, NY, USA
    Front Neurosci 6:69. 2012
    ..Here we used Olig2-cre conditional deletion of Dicer gene in motor neuron progenitors to examine effects of miRNA biogenesis ..
  78. pmc Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling
    Kelvin King Lo Law
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Tower, Toronto, Ontario, Canada
    PLoS ONE 7:e50193. 2012
    ....
  79. pmc Adenomatous polyposis coli regulates oligodendroglial development
    Jordan Lang
    Institute for Pediatric Regenerative Medicine, University of California, Davis, School of Medicine and Shriners Hospital, Sacramento, California 95817, USA
    J Neurosci 33:3113-30. 2013
    ..Together, our data support the hypothesis that APC regulates oligodendrocyte differentiation through both β-catenin-dependent and additional β-catenin-independent mechanisms...
  80. pmc Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination
    Amélie Wegener
    1 INSERM, U 1127, F 75013, Paris, France 1 Inserm, U 1127, F 75013, Paris, France 1 Inserm, U 1127, F 75013, Paris, France 1 Inserm, U 1127, F 75013, Paris, France 1 Inserm, U 1127, F 75013, Paris, France
    Brain 138:120-35. 2015
    The basic helix-loop-helix transcription factor Olig2 is a key determinant for the specification of neural precursor cells into oligodendrocyte progenitor cells...
  81. ncbi Olig2 directs astrocyte and oligodendrocyte formation in postnatal subventricular zone cells
    Christine A G Marshall
    Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 25:7289-98. 2005
    ..Here, we demonstrate that the basic helix-loop-helix transcription factor Olig2 plays a central role in this process...
  82. ncbi A crucial role for Olig2 in white matter astrocyte development
    Jeff Cai
    Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Development 134:1887-99. 2007
    ..The bHLH transcription factor Olig2 is essential for motoneuron and oligodendrocyte formation; however, its role in astrocyte development remains ..
  83. doi Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning
    Chester E Chamberlain
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 135:1097-106. 2008
    ..This study, in which we directly observe, measure, localize and modify notochord-derived Shh ligand in the context of neural patterning, provides several new insights into mechanisms of Shh morphogen action...
  84. pmc Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination
    Ben Emery
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305 5125, USA
    Cell 138:172-85. 2009
    ..These findings establish MRF as a critical transcriptional regulator essential for oligodendrocyte maturation and CNS myelination...
  85. ncbi Differential regulation of basic helix-loop-helix factors Mash1 and Olig2 by beta-amyloid accelerates both differentiation and death of cultured neural stem/progenitor cells
    Yoko Uchida
    Gene Expression Research Group, Research Team for Geriatric Disorders, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashiku, Tokyo 173 0015, Japan
    J Biol Chem 282:19700-9. 2007
    ..Up-regulation of Mash1 and down-regulation of Olig2 were found in cerebral cortical cultures treated with Abeta-(1-42)...
  86. doi Dual function of suppressor of fused in Hh pathway activation and mouse spinal cord patterning
    Jinling Liu
    Department of Biology, Eberly College of Science, Center for Cellular Dynamics, Huck Institute of Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Dev Biol 362:141-53. 2012
    ..Finally, by altering the level of Gli3 repressor on a background of reduced Gli activator activities, we reveal an important contribution of Gli3 repressor activity to the Hh pathway activation and the D/V patterning of the spinal cord...
  87. ncbi Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain
    S Nery
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Development 128:527-40. 2001
    ..We show that in the forebrain, expression of the early oligodendrocyte markers Olig2, plp/dm20 and PDGFR(alpha) corresponds to regions of Shh expression...
  88. ncbi Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain
    Alexandre Pattyn
    Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Development 130:4149-59. 2003
    ..the loss of motoneurons at this level correlates with the extinguished expression of the motoneuron determinant Olig2. Unexpectedly, we find that the initial expression of Olig2 is left intact in the caudal hindbrain of Nkx6.1/Nkx6...
  89. ncbi Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord
    Qiubo Lei
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Development 131:3593-604. 2004
    ..Thus, multiple ventral neuronal types can develop in the absence of Gli function, but require balanced Gli protein activities for their correct patterning and differentiation...
  90. ncbi Sox group E gene expression distinguishes different types and maturational stages of glial cells in developing chick and mouse
    Uwe Kordes
    Department of Pediatric Hematology and Oncology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Brain Res Dev Brain Res 157:209-13. 2005
    ..Sox8 appeared both in oligodendrocytes and astrocytes, Sox9 was more abundant in astrocytes and Sox10 was restricted to later stages of oligodendrocyte development...
  91. ncbi Epidermal growth factor signaling mediated by grb2 associated binder1 is required for the spatiotemporally regulated proliferation of olig2-expressing progenitors in the embryonic spinal cord
    Yoshika Hayakawa-Yano
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Stem Cells 25:1410-22. 2007
    ..Here, we show that Gab1 deficiency results in a reduction in the number of Olig2-positive (Olig2(+)) progenitor cells in the developing mouse spinal cord after embryonic day 12.5 (E12...
  92. pmc The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development
    Benjamin L Allen
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 21:1244-57. 2007
    ....
  93. pmc Lateral motor column axons execute a ternary trajectory choice between limb and body tissues
    Victor Luria
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Neural Dev 2:13. 2007
    ..The cellular logic that guides motor axon trajectory choices into non-limb tissues such as the ventral flank remains unclear...
  94. doi Combinatorial signalling controls Neurogenin2 expression at the onset of spinal neurogenesis
    Vanessa Ribes
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U 596, CNRS UMR 7104, Universite Louis Pasteur, 1 rue Laurent Fries, Illkirch, BP 10142 F 67400, France
    Dev Biol 321:470-81. 2008
    ..Our data thus support a model where signal integration at the level of a single enhancer constitutes a key mechanism to control the onset of neurogenesis...
  95. pmc Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development
    Joseph A Brzezinski
    University of Washington, Department of Biological Structure, Seattle, WA 98195, USA
    Development 137:619-29. 2010
    ..We conclude that Blimp1 regulates the decision between photoreceptor and bipolar cell fates in the Otx2(+) cell population during retinal development...
  96. doi ERK1 and ERK2 are required for radial glial maintenance and cortical lamination
    Osamu Imamura
    Department of Biochemistry, National Defense Medical College, 3 2 Namiki, Tokorozawa 359 8513, Japan
    Genes Cells 15:1072-88. 2010
    ..These data demonstrate functional overlaps between ERK1 and ERK2 and indicate that extracellular signal-regulated kinase signaling plays a crucial role in cortical development...
  97. pmc Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube
    Alisa S W Shum
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Dev Dyn 239:3192-203. 2010
    ..Taken together, these results support that the lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube...
  98. pmc The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development
    Jingyang Zhong
    The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Development 138:409-19. 2011
    ..Ryk controls the cell-fate switch by negatively regulating expression of the intrinsic oligodendrogenic factor Olig2 while inducing expression of the interneuron fate determinant Dlx2...
  99. pmc Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma
    Michelle Monje
    Department of Neurology, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:4453-8. 2011
    ..Together, these findings provide a foundation for understanding the cellular and molecular origins of DIPG, and suggest that the Hh pathway represents a potential therapeutic target in this devastating pediatric tumor...
  100. pmc Disrupted dorsal neural tube BMP signaling in the cilia mutant Arl13b hnn stems from abnormal Shh signaling
    Vanessa L Horner
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Biol 355:43-54. 2011
    ..We demonstrate that Arl13b is required non-autonomously for BMP signaling and Wnt ligand expression, indicating that the abnormal Shh signaling environment in Arl13b(hnn) embryos indirectly causes dorsal defects...
  101. pmc Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination
    Stephen P J Fancy
    Department of Pediatrics and Neurosurgery, Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine and Howard Hughes Medical Institute, University of California, San Francisco, California, USA
    Nat Neurosci 14:1009-16. 2011
    ..Together, these findings indicate that Axin2 is an essential regulator of remyelination and that it might serve as a pharmacological checkpoint in this process...

Research Grants5

  1. Development of Sensory maps in the Mammalian neocortex
    Yasushi Nakagawa; Fiscal Year: 2010
    ..abstract_text> ..
  2. Neurogenesis, Inflammation and Irradiation Injury
    MICHELLE MONJE DEISSEROTH; Fiscal Year: 2003
    ..abstract_text> ..
  3. Notch Signaling in Olfactory Progenitor Cell Fate
    TIMOTHY HENION; Fiscal Year: 2004
    ..The results obtained from these preliminary studies will provide important information on the mechanisms which regulate cell diversity in the olfactory system, and potentially other neurogenic tissues. ..
  4. Olig function in CNS development and tumorigenesis
    Keith Ligon; Fiscal Year: 2008
    ..The basic helix-loop-helix transcription factor, Olig2, is essential for motor neuron and oligodendrocyte development in the mouse spinal cord...
  5. PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINS
    Rashmi Bansal; Fiscal Year: 2009
    ....