Panx1

Summary

Gene Symbol: Panx1
Description: pannexin 1
Alias: AI847747, pannexin-1
Species: mouse

Top Publications

  1. ncbi Localization of the pannexin1 protein at postsynaptic sites in the cerebral cortex and hippocampus
    G Zoidl
    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitystreet 150, D 44780 Bochum, Germany
    Neuroscience 146:9-16. 2007
  2. pmc Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis
    Brian D Gulbransen
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Med 18:600-4. 2012
  3. doi The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials
    Stefanie Bunse
    Department of Neuroanatomy and Molecular Brain Research, Ruhr University, Bochum, Germany
    FEBS J 276:6258-70. 2009
  4. pmc Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions
    Ruchi Bhalla-Gehi
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 285:9147-60. 2010
  5. pmc The P2X7 receptor-pannexin-1 complex decreases muscarinic acetylcholine receptor-mediated seizure susceptibility in mice
    Ji Eun Kim
    Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon, South Korea
    J Clin Invest 121:2037-47. 2011
  6. doi Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation
    Yan Qu
    Physiological Chemistry Department, Genentech, Inc, South San Francisco, CA 94080, USA
    J Immunol 186:6553-61. 2011
  7. pmc Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction
    Marie Billaud
    Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Circ Res 109:80-5. 2011
  8. pmc Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia
    Lucia Seminario-Vidal
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:26277-86. 2011
  9. pmc Targeting pannexin1 improves seizure outcome
    Marcelo F Santiago
    The Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 6:e25178. 2011
  10. pmc Two non-vesicular ATP release pathways in the mouse erythrocyte membrane
    Feng Qiu
    Department of Physiology and Biophysics, University of Miami, School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    FEBS Lett 585:3430-5. 2011

Research Grants

  1. Calcium Buffering Mechanisms in Taste Cells
    Kathryn Medler; Fiscal Year: 2006
  2. Functional Analysis of Inner Ear Gap Junctions
    Hong Bo Zhao; Fiscal Year: 2008
  3. EARLY HUSBANDRY INFLUENCES ON ADULT PHENOTYPE
    MICHAEL TORDOFF; Fiscal Year: 2009
  4. KCNRG gene as candidate tumor suppressor for CLL and MM
    Anna Baranova; Fiscal Year: 2005

Scientific Experts

  • Dina Gaynullina
  • Paloma A Harcha
  • MICHAEL TORDOFF
  • Aurelie Vandenbeuch
  • Kathryn Medler
  • Hong Bo Zhao
  • Peter J Hanley
  • Mia M Thi
  • Nobuhiko Kayagaki
  • Roger J Thompson
  • Irma Lemaire
  • Yan Huang
  • Galina Dvoriantchikova
  • David Brough
  • Brian D Gulbransen
  • ANNA V BARANOVA
  • Silvia Penuela
  • Dale W Laird
  • Eliana Scemes
  • Feng Qiu
  • Gerhard Dahl
  • Leigh E Wicki-Stordeur
  • Sylvia O Suadicani
  • Hannah Monyer
  • David C Spray
  • Leigh Anne Swayne
  • Hiromitsu Negoro
  • Georg Zoidl
  • Junjie Wang
  • Rolf Dermietzel
  • Sarah E Lutz
  • Panagiotis Bargiotas
  • Stefanie Bunse
  • Qing Shao
  • Steven J Celetti
  • Andrew K J Boyce
  • Douglas A Bayliss
  • Kodi S Ravichandran
  • Naman K Patel
  • Joanna K Sandilos
  • Alexander W Lohman
  • Nora Prochnow
  • Marie Billaud
  • Valery I Shestopalov
  • Gabriel Nunez
  • Rodolfo Iglesias
  • Ruchi Bhalla
  • Wing Yee Cheung
  • Abdulrahman Raslan
  • Abraham Cisneros-Mejorado
  • Dahai Yang
  • F Molica
  • Sheriar G Hormuzdi
  • Alberto Pérez-Samartín
  • Hiroshi Yamaguchi
  • Carlos Matute
  • Ivan K H Poon
  • Manuel A Riquelme
  • HongBin Wang
  • Katharina Kranz
  • Hulya Karatas
  • Cinzia Ambrosi
  • Allison J Armstrong
  • Regina Hanstein
  • Yu Hsin Chiu
  • Arundhati Ray
  • Michael V L Bennett
  • Svenja Weickert
  • Anne Charollais
  • Paolo Meda
  • Brian A Bao
  • Honghong Zhang
  • Haiying Zhan
  • Chiara Rigato
  • Elena Dolmatova
  • Fiona Hanner
  • Md Rafiqul Islam
  • Roman A Romanov
  • Nicholas L Weilinger
  • Markus Schwaninger
  • Adam C Straub
  • Faraaz B Chekeni
  • Brant E Isakson
  • Antje Krenz
  • Lucia Seminario-Vidal
  • Marcelo F Santiago
  • Ji Eun Kim
  • Yan Qu
  • Jared M Churko
  • Ruchi Bhalla-Gehi

Detail Information

Publications80

  1. ncbi Localization of the pannexin1 protein at postsynaptic sites in the cerebral cortex and hippocampus
    G Zoidl
    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitystreet 150, D 44780 Bochum, Germany
    Neuroscience 146:9-16. 2007
    ..Here we demonstrate by light and electron microscopical immunohistochemistry that Panx1 reveals postsynaptic localization in rodent hippocampal and cortical principal neurons accumulating at ..
  2. pmc Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis
    Brian D Gulbransen
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Med 18:600-4. 2012
    ..enteric neuron death by activating a neuronal signaling complex composed of P2X7 receptors (P2X7Rs), pannexin-1 (Panx1) channels, the Asc adaptor protein and caspases...
  3. doi The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials
    Stefanie Bunse
    Department of Neuroanatomy and Molecular Brain Research, Ruhr University, Bochum, Germany
    FEBS J 276:6258-70. 2009
    b>Pannexin 1 (Panx1), a member of the second gap junction protein family identified in vertebrates, appears to preferentially form non-junctional membrane channels...
  4. pmc Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions
    Ruchi Bhalla-Gehi
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 285:9147-60. 2010
    ..In this study, we utilized Cx43-positive BICR-M1R(k) cells to stably express Panx1, Panx3, or Panx1-green fluorescent protein (GFP) to assess their trafficking, cell surface dynamics, and interplay ..
  5. pmc The P2X7 receptor-pannexin-1 complex decreases muscarinic acetylcholine receptor-mediated seizure susceptibility in mice
    Ji Eun Kim
    Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon, South Korea
    J Clin Invest 121:2037-47. 2011
    Pannexin-1 (Panx1) plays a role in the release of ATP and glutamate in neurons and astrocytes. Panx1 can be opened at the resting membrane potential by extracellular ATP via the P2X7 receptor (P2X7R)...
  6. doi Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation
    Yan Qu
    Physiological Chemistry Department, Genentech, Inc, South San Francisco, CA 94080, USA
    J Immunol 186:6553-61. 2011
    ..Cell death was not delayed but, unlike their wild-type counterparts, Panx1(-/-) thymocytes failed to recruit wild-type peritoneal macrophages in a Transwell migration assay...
  7. pmc Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction
    Marie Billaud
    Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Circ Res 109:80-5. 2011
    ..Pannexins (Panx) are purine-releasing channels permeable to the vasoconstrictor ATP and thus may play a role in the coordination of vascular smooth muscle cell constriction...
  8. pmc Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia
    Lucia Seminario-Vidal
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:26277-86. 2011
    ..Using knockdown and knockout approaches, we tested the hypothesis that pannexin 1 mediates ATP release from hypotonically swollen airway epithelia and investigated mechanisms regulating this ..
  9. pmc Targeting pannexin1 improves seizure outcome
    Marcelo F Santiago
    The Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 6:e25178. 2011
    ..Pannexin1 (Panx1) is found in astrocytes and in neurons at high levels in the embryonic and young postnatal brain, declining in ..
  10. pmc Two non-vesicular ATP release pathways in the mouse erythrocyte membrane
    Feng Qiu
    Department of Physiology and Biophysics, University of Miami, School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    FEBS Lett 585:3430-5. 2011
    ..Previous studies have indicated, that Pannexin1 (Panx1) provides a key ATP permeation pathway in many cell types, including human and frog erythrocytes...
  11. pmc Pannexins in ischemia-induced neurodegeneration
    Panagiotis Bargiotas
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, 23538 Lubeck, Germany
    Proc Natl Acad Sci U S A 108:20772-7. 2011
    b>Pannexin 1 (Px1, Panx1) and pannexin 2 (Px2, Panx2) form large-pore nonselective channels in the plasma membrane of cells and were suggested to play a role in the pathophysiology of cerebral ischemia...
  12. pmc Pannexin1 drives multicellular aggregate compaction via a signaling cascade that remodels the actin cytoskeleton
    Brian A Bao
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Center for Biomedical Engineering, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 287:8407-16. 2012
    b>Pannexin 1 (Panx1) is a novel gap junction protein shown to have tumor-suppressive properties...
  13. pmc Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region
    Joanna K Sandilos
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 287:11303-11. 2012
    b>Pannexin 1 (PANX1) channels mediate release of ATP, a "find-me" signal that recruits macrophages to apoptotic cells; PANX1 activation during apoptosis requires caspase-mediated cleavage of PANX1 at its C terminus, but how the C terminus ..
  14. pmc Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury
    Galina Dvoriantchikova
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 7:e31991. 2012
    Pannexin1 (Panx1) forms large nonselective membrane channel that is implicated in paracrine and inflammatory signaling. In vitro experiments suggested that Panx1 could play a key role in ischemic death of hippocampal neurons...
  15. pmc Pannexins, a family of gap junction proteins expressed in brain
    Roberto Bruzzone
    Department of Clinical Neurobiology, Interdisciplinary Center for Neurosciences, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 100:13644-9. 2003
    ..Here, we show that two of these genes, pannexin 1 (Px1) and Px2, are abundantly expressed in the CNS...
  16. pmc Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation
    Leigh E Wicki-Stordeur
    Division of Medical Sciences, Island Medical Program, University of Victoria, Victoria, British Columbia, Canada
    Neural Dev 7:11. 2012
    b>Pannexin 1 forms ion and metabolite permeable hexameric channels and is abundantly expressed in the brain...
  17. pmc ATP signaling is deficient in cultured Pannexin1-null mouse astrocytes
    Sylvia O Suadicani
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Glia 60:1106-16. 2012
    Pannexins (Panx1, 2, and 3) comprise a group of proteins expressed in vertebrates that share weak yet significant sequence homology with the invertebrate gap junction proteins, the innexins...
  18. pmc Contribution of pannexin1 to experimental autoimmune encephalomyelitis
    Sarah E Lutz
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS ONE 8:e66657. 2013
    Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells...
  19. pmc Connexin43 and pannexin1 channels in osteoblasts: who is the "hemichannel"?
    Mia M Thi
    Department of Orthopedic Surgery, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Membr Biol 245:401-9. 2012
    ..and ATP-induced dye uptake is attenuated following treatment of wild-type cells with a P2X₇R or Pannexin1 (Panx1) channel blocker...
  20. ncbi Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion
    Chiara Rigato
    Institut National de la Sante et de la Recherche Medicale, U952, Universite Pierre et Marie Curie, Paris, Ile de France, France
    J Neurosci 32:11559-73. 2012
    ..These results reveal a developmental role of P2X7R by controlling embryonic SC microglia proliferation at a critical developmental state in the SC of mouse embryos...
  21. pmc Pannexin 1 involvement in bladder dysfunction in a multiple sclerosis model
    Hiromitsu Negoro
    Department of Urology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Sci Rep 3:2152. 2013
    ..altered expression of genes associated with bladder mechanosensory, transduction and signaling systems including pannexin 1 (Panx1) and Gja1 (encoding connexin43, referred to here as Cx43)...
  22. pmc Intrarenal localization of the plasma membrane ATP channel pannexin1
    Fiona Hanner
    Department of Physiology and Biophysics, Univ of Southern California, Los Angeles, CA 90033, USA
    Am J Physiol Renal Physiol 303:F1454-9. 2012
    ..However, the mechanisms by which ATP is released into the tubular lumen are multifaceted. Pannexin1 (Panx1) is a newly identified...
  23. pmc The ATP permeability of pannexin 1 channels in a heterologous system and in mammalian taste cells is dispensable
    Roman A Romanov
    Institute of Cell Biophysics, Russian Academy of Sciences, Institutional Street 3, Pushchino, Moscow Region, 142290, Russia
    J Cell Sci 125:5514-23. 2012
    ..It is widely accepted that pannexin 1 (Panx1) channels are responsible for ATP release in diverse cell types, including taste cells...
  24. pmc Promises and pitfalls of a Pannexin1 transgenic mouse line
    Regina Hanstein
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University New York, NY, USA
    Front Pharmacol 4:61. 2013
    ..Here, we report the use of an efficient molecular biological approach to test pannexin1 (Panx1) mRNA expression in global and conditional Panx1 KO mice derived from the KO-first mouse line, Panx1(tm1a(KOMP)..
  25. doi Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization
    Leigh E Wicki-Stordeur
    Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada
    Cell Commun Adhes 20:73-9. 2013
    ..Recent elegant work has demonstrated that the Panx1 C-terminus plays an important role in channel trafficking...
  26. doi The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels
    Manuel A Riquelme
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago 8, Chile
    Neuropharmacology 75:594-603. 2013
    ..We found that ATP appears to be released through pannexin1 hemichannels (Panx1 HCs)...
  27. doi Spreading depression triggers headache by activating neuronal Panx1 channels
    Hulya Karatas
    Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey
    Science 339:1092-5. 2013
    ..CSD caused neuronal Pannexin1 (Panx1) megachannel opening and caspase-1 activation followed by high-mobility group box 1 (HMGB1) release from neurons ..
  28. pmc Pannexin 1: the molecular substrate of astrocyte "hemichannels"
    Rodolfo Iglesias
    The Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 29:7092-7. 2009
    ..Here, we provide strong evidence that, in cultured astrocytes, pannexin1 (Panx1) but not Cx43 forms hemichannels...
  29. ncbi The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins
    Ancha Baranova
    Vavilov Institute of General Genetics RAS, Gubkina str, 3 GSP 1, Moscow 119991, Russia
    Genomics 83:706-16. 2004
    We have cloned the genes PANX1, PANX2 and PANX3, encoding putative gap junction proteins homologous to invertebrate innexins, which constitute a new family of mammalian proteins called pannexins...
  30. ncbi A ubiquitous family of putative gap junction molecules
    Y Panchin
    Curr Biol 10:R473-4. 2000
  31. ncbi Site-specific and developmental expression of pannexin1 in the mouse nervous system
    Arundhati Ray
    Department of Neuroanatomy and Molecular Brain Research, Faculty of Medicine, Ruhr University, Bochum, Germany
    Eur J Neurosci 21:3277-90. 2005
    ..We investigated the spatio-temporal mRNA distribution of one member of this gene family, pannexin1 (Panx1), in the brain and retina of mice using quantitative real-time polymerase chain reaction and a combination of in ..
  32. ncbi Pannexin1 and Pannexin2 expression in the developing and mature rat brain
    Angelika Vogt
    Department of Clinical Neurobiology, Interdisciplinary Center for Neuroscience, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Brain Res Mol Brain Res 141:113-20. 2005
    ..Furthermore, the temporal difference in the expression of the two genes indicates that the relative contribution of the two pannexins in immature and mature neuronal circuits may vary...
  33. ncbi Expression of pannexin family of proteins in the retina
    Galina Dvoriantchikova
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    FEBS Lett 580:2178-82. 2006
    Expression of the Panx1 and Panx2 members of the pannexin family of gap junction proteins was studied in the retina by in situ hybridization and qRT-PCR...
  34. ncbi Pannexin1 is expressed by neurons and glia but does not form functional gap junctions
    Yan Huang
    Department of Neurology, The University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6077, USA
    Glia 55:46-56. 2007
    ..We made antisera against mouse pannexin1 (Panx1)...
  35. ncbi Molecular characterization of pannexins in the lens
    Galina Dvoriantchikova
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Mol Vis 12:1417-26. 2006
    ..The expression of the recently characterized Panx1 and Panx2 gap junction proteins in the lens is, therefore, rather intriguing...
  36. pmc The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds
    Yi Jen Huang
    Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 104:6436-41. 2007
    ..receptors as biosensors, we show that gustatory stimuli cause receptor cells to secrete ATP through pannexin 1 hemichannels in mouse taste buds...
  37. ncbi Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling
    Thirumala Devi Kanneganti
    Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Immunity 26:433-43. 2007
    ..These results provide evidence for cytosolic delivery and sensing of bacterial molecules as a unifying model for caspase-1 activation and position pannexin-1 as a mechanistic link between bacterial stimuli and the cryopyrin inflammasome...
  38. ncbi Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins
    Silvia Penuela
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, N6A 5C1, Canada
    J Cell Sci 120:3772-83. 2007
    ..Localization of exogenously expressed pannexin 1 (Panx1) and pannexin 3 (Panx3), together with pharmacological studies, revealed a cell surface distribution ..
  39. ncbi P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage
    Pablo Pelegrin
    Faculty of Life Science, University of Manchester, Manchester, United Kingdom
    J Immunol 180:7147-57. 2008
    ..by ATP resulted exclusively from activation of P2X(7)R, release of all these IL-1 cytokines involved pannexin-1 (panx1), and that there was both a panx1-dependent and -independent component to IL-1beta release...
  40. pmc P2X7 receptor-Pannexin1 complex: pharmacology and signaling
    R Iglesias
    The Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Physiol Cell Physiol 295:C752-60. 2008
    b>Pannexin 1 (Panx1), an ortholog to invertebrate innexin gap junctions, has recently been proposed to be the pore induced by P2X(7) receptor (P2X(7)R) activation...
  41. pmc Glycosylation regulates pannexin intermixing and cellular localization
    Silvia Penuela
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Mol Biol Cell 20:4313-23. 2009
    The pannexin family of mammalian proteins, composed of Panx1, Panx2, and Panx3, has been postulated to be a new class of single-membrane channels with functional similarities to connexin gap junction proteins...
  42. pmc The pannexin 1 channel activates the inflammasome in neurons and astrocytes
    William R Silverman
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 284:18143-51. 2009
    ..In primary macrophages, potassium ion flux and the membrane channel pannexin 1 have been suggested to play roles in inflammasome activation...
  43. pmc A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP
    Feng Qiu
    Dept of Physiology and Biophysics, Univ of Miami School of Medicine, PO Box 016430, Miami, FL 33101, USA
    Am J Physiol Cell Physiol 296:C250-5. 2009
    b>Pannexin 1 forms a large membrane channel that, based on its biophysical properties and its expression pattern, is a prime candidate to represent an ATP release channel...
  44. pmc Identification and characterization of pannexin expression in the mammalian cochlea
    Xiao Hui Wang
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Comp Neurol 512:336-46. 2009
    ..To date, three pannexin isoforms (Panx1, 2, and 3) have been cloned from mouse and human genomes...
  45. pmc Pannexin 1 contributes to ATP release in airway epithelia
    George A Ransford
    Division of Pulmonary and Critical Care Medicine R 47, University of Miami Miller School of Medicine, 1600 NW 10th Ave, RMSB 7058, Miami, FL 33136, USA
    Am J Respir Cell Mol Biol 41:525-34. 2009
    ..Thus, ATP release via pannexons was examined in airway epithelial cells. Quantitative RT-PCR showed Panx1 expression in normal human airway epithelial cells during redifferentiation at the air-liquid interface (ALI), at ..
  46. pmc ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear
    Fabio Anselmi
    Foundation for Advanced Biomedical Research, Venetian Institute of Molecular Medicine, 35129 Padua, Italy
    Proc Natl Acad Sci U S A 105:18770-5. 2008
    ....
  47. doi Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus
    Roger J Thompson
    Department of Psychiatry and Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Science 322:1555-9. 2008
    ..We conclude that Px1 hemichannel opening is triggered by NMDAR stimulation and can contribute to epileptiform seizure activity...
  48. pmc Blockade of P2X7 receptors or pannexin-1 channels similarly attenuates postischemic damage
    Abraham Cisneros-Mejorado
    Achucarro Basque Center for Neuroscience, Departamento de Neurociencias and CIBERNED, Universidad del Pais Vasco UPV EHU, Leioa, Spain
    J Cereb Blood Flow Metab 35:843-50. 2015
    ..reduced with P2X7 and pannexin-1 blockers as well as in organotypic cultures derived from mice lacking P2X7 and pannexin 1. Subsequently, we used transient middle cerebral artery occlusion to monitor the neuroprotective effect of those ..
  49. pmc Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock
    Dahai Yang
    Department of Pathology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
    Immunity 43:923-32. 2015
    ..agonist resulted in high mortality in wild-type mice after secondary LPS challenge, but not in Casp11(-/-), Panx1(-/-), or P2x7(-/-) mice...
  50. pmc Pannexin 1 deficiency can induce hearing loss
    Hong Bo Zhao
    Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, United States Electronic address
    Biochem Biophys Res Commun 463:143-7. 2015
    ..Pannexin (Panx) gene also encodes gap junction proteins in vertebrates. Panx1 is a predominant pannexin isoform and has extensive expression in the cochlea...
  51. doi Functional role of a polymorphism in the Pannexin1 gene in collagen-induced platelet aggregation
    F Molica
    Brenda R Kwak, PhD, Department of Pathology and Immunology, Department of Medical Specializations Cardiology, University of Geneva, Rue Michel Servet 1, 1211 Geneva Switzerland, Tel 41 22 379 57 37, Fax 41 22 379 57 46, E mail
    Thromb Haemost 114:325-36. 2015
    Pannexin1 (Panx1) forms ATP channels that play a critical role in the immune response by reinforcing purinergic signal amplification in the immune synapse...
  52. doi Hemichannels Are Required for Amyloid β-Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice
    Paloma A Harcha
    Departamento de Fisiologia, Pontificia Universidad Catülica de Chile, Santiago, Chile, Instituto Milenio, Centro Interdisciplinario de Neurociencias de Valparaíso, Valparaiso, Chile
    J Neurosci 35:9526-38. 2015
    ..In the present work, we found a rapid degranulation of cultured MCs through a pannexin1 hemichannel (Panx1 HC)-dependent mechanism induced by Aβ25-35 peptide...
  53. pmc Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells
    Hiroshi Yamaguchi
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    elife 3:e02172. 2014
    ..Intraperitoneal injection of zymosan into Adora2a- or Panx1-deficient mice produced high, sustained levels of inflammatory mediators in the peritoneal lavage...
  54. pmc Panx1 regulates neural stem and progenitor cell behaviours associated with cytoskeletal dynamics and interacts with multiple cytoskeletal elements
    Leigh E Wicki-Stordeur
    Division of Medical Sciences, Island Medical Program, University of Victoria, Victoria, British Columbia, Canada
    Cell Commun Signal 11:62. 2013
    ..Although no proteomics-based interactome has yet been published, Panx1 has been demonstrated to interact with actin in an ectopic expression system...
  55. pmc Unexpected link between an antibiotic, pannexin channels and apoptosis
    Ivan K H Poon
    1 The Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA 2 Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, USA 3 Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA 4 La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia
    Nature 507:329-34. 2014
    Plasma membrane pannexin 1 channels (PANX1) release nucleotide find-me signals from apoptotic cells to attract phagocytes...
  56. pmc Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes
    Wing Yee Cheung
    Department of Biomedical Engineering, City College of New York, New York, NY, USA
    J Bone Miner Res 31:890-9. 2016
    ..Apoptosis has been shown to open pannexin-1 (Panx1) channels to release adenosine diphosphate (ATP) as a "find-me" signal for phagocytic cells...
  57. pmc The membrane protein Pannexin1 forms two open-channel conformations depending on the mode of activation
    Junjie Wang
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33136, USA
    Sci Signal 7:ra69. 2014
    Pannexin1 (Panx1) participates in several signaling events that involve adenosine triphosphate (ATP) release, including the innate immune response, ciliary beat in airway epithelia, and oxygen supply in the vasculature...
  58. doi ATP stimulates pannexin 1 internalization to endosomal compartments
    Andrew K J Boyce
    Division of Medical Sciences and Island Medical Program, University of Victoria, Victoria, Canada V8P 5C2
    Biochem J 470:319-30. 2015
    The ubiquitous pannexin 1 (Panx1) ion- and metabolite-permeable channel mediates the release of ATP, a potent signalling molecule...
  59. doi Pannexin-1 expression in developing mouse nervous system: new evidence for expression in sensory ganglia
    Abdulrahman Raslan
    Department of Anatomy and Cell Biology, Saarland University, Building 61, 66424, Homburg, Saar, Germany
    Cell Tissue Res 364:29-41. 2016
    Pannexin1 (Panx1) is one of three members of the pannexin protein family. The expression of Panx1 mRNA has been extensively investigated from late embryonic to adult stages...
  60. doi Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases
    Nicholas L Weilinger
    Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Neurosci 32:12579-88. 2012
    ..Pannexin-1 (Panx1) channels can be activated both by ischemia and NMDA receptors (NMDARs), but the mechanisms of Panx1 activation ..
  61. pmc Pannexin1 stabilizes synaptic plasticity and is needed for learning
    Nora Prochnow
    Neuroanatomy, Medical Faculty, Ruhr University Bochum, Bochum, Germany
    PLoS ONE 7:e51767. 2012
    b>Pannexin 1 (Panx1) represents a class of vertebrate membrane channels, bearing significant sequence homology with the invertebrate gap junction proteins, the innexins and more distant similarities in the membrane topologies and ..
  62. doi Diverse subcellular distribution profiles of pannexin 1 and pannexin 3
    Silvia Penuela
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Cell Commun Adhes 15:133-42. 2008
    ..Localization of untagged Panx1 and Panx3 exogenously expressed in five cultured cell lines revealed a cell surface distribution profile with ..
  63. doi Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation
    Steven J Celetti
    Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    J Cell Sci 123:1363-72. 2010
    ..In this study, Panx1 and Panx3 were detected in the epidermis of 13.5 day embryonic mice...
  64. doi Non-canonical inflammasome activation targets caspase-11
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech Inc, South San Francisco, California 94080, USA
    Nature 479:117-21. 2011
    ..These data highlight a unique pro-inflammatory role for caspase-11 in the innate immune response to clinically significant bacterial infections...
  65. pmc Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins
    Peter J Hanley
    Institut für Molekulare Zellbiologie, Westfalische Wilhelms Universitat Munster, 48149 Munster, Germany
    J Biol Chem 287:10650-63. 2012
    ..Furthermore, pannexin-1 (Panx1) deficiency had no effect on transient ATP-induced delayed cell death or ATP-induced Yo-Pro-1 uptake (an index of ..
  66. pmc Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype
    Silvia Penuela
    Department of Anatomy and Cell BiologyUniversity of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 287:29184-93. 2012
    b>Pannexin 1 (Panx1) is a channel-forming glycoprotein expressed in different cell types of mammalian skin...
  67. pmc Stomatin inhibits pannexin-1-mediated whole-cell currents by interacting with its carboxyl terminal
    Haiying Zhan
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, United States of America
    PLoS ONE 7:e39489. 2012
    The pannexin-1 (Panx1) channel (often referred to as the Panx1 hemichannel) is a large-conductance channel in the plasma membrane of many mammalian cells...
  68. doi Maxi-anion channel and pannexin 1 hemichannel constitute separate pathways for swelling-induced ATP release in murine L929 fibrosarcoma cells
    Md Rafiqul Islam
    Dept of Cell Physiology, National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444 8585, Japan
    Am J Physiol Cell Physiol 303:C924-35. 2012
    ..Also, it was found that the cells express the mRNA for pannexin 1, pannexin 2, and connexin 43...
  69. doi Patterns of heterogeneous expression of pannexin 1 and pannexin 2 transcripts in the olfactory epithelium and olfactory bulb
    Honghong Zhang
    Department of Biological and Chemical Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA
    J Mol Histol 43:651-60. 2012
    ..Here, we report expression patterns of pannexin 1 (Panx1) and pannexin 2 (Panx2) in the olfactory epithelium and olfactory bulb of adult mice...
  70. doi Expression of Pannexin1 in the outer plexiform layer of the mouse retina and physiological impact of its knockout
    Katharina Kranz
    Department of Neurobiology, University of Oldenburg, D 26111 Oldenburg, Germany
    J Comp Neurol 521:1119-35. 2013
    Pannexin1 (Panx1) belongs to a class of vertebrate proteins that exhibits sequence homology to innexins, the invertebrate gap junction proteins, and which also shares topological similarities with vertebrate gap junction proteins, the ..
  71. pmc Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation
    Elena Dolmatova
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Am J Physiol Heart Circ Physiol 303:H1208-18. 2012
    ..In immune cells, ATP release from pannexin 1 (Panx1) channels acts as a paracrine signal initiating activation of innate immunity...
  72. pmc Pannexin-1 influences peritoneal cavity cell population but is not involved in NLRP3 inflammasome activation
    HongBin Wang
    Unit of Innate Immunity, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai 200025, China
    Protein Cell 4:259-65. 2013
    Pannexin-1 (Panx1) forms nonselective large channel in cell plasma membrane and has been shown to be associated with NLRP3 inflammasome activation, ATP release and phagocytes recruitment...
  73. pmc S-nitrosylation inhibits pannexin 1 channel function
    Alexander W Lohman
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 287:39602-12. 2012
    S-nitrosylation is a post-translational modification on cysteine(s) that can regulate protein function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric oxide (NO) species...
  74. pmc Functional outcome of pannexin-deficient mice after cerebral ischemia
    Panagiotis Bargiotas
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Lubeck, Germany
    Channels (Austin) 6:453-6. 2012
    ..Pannexin double-knockout mice (Px1(-/-) Px2(-/-)) were less impaired in parameters such as exploration, anxiety, sensorimotor function and behavioral symmetry...
  75. doi The P2X7 receptor and Pannexin-1 are both required for the promotion of multinucleated macrophages by the inflammatory cytokine GM-CSF
    Irma Lemaire
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Immunol 187:3878-87. 2011
    ..These data demonstrate that both P2X(7) and Panx-1 are required for GM-CSF promotion of MA fusion but likely act independently through different signaling pathway(s)...
  76. pmc Intracellular cysteine 346 is essentially involved in regulating Panx1 channel activity
    Stefanie Bunse
    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, 44780 Bochum, Germany
    J Biol Chem 285:38444-52. 2010
    ..properties of the connexin-type we performed site-directed mutagenesis of intracellular cysteine residues of Panx1. Cysteine to serine exchange (Cys → Ser) at the C-terminal position amino acid 346 led to a constitutively leaky ..
  77. pmc Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc
    David Brough
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Eur J Immunol 39:352-8. 2009
    ..These data provide new insights into the mechanisms of caspase-1 activation and how zinc metabolism contributes to inflammatory mechanisms...
  78. pmc Pannexins are new molecular candidates for assembling gap junctions in the cochlea
    Wenxue Tang
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia, USA
    Neuroreport 19:1253-7. 2008
    ..Western blot and reverse transcription-PCR detected the expression of Panx1 and Panx2. Immunolabeling localized Panx1 to the inner and outer sulcus, as well as the Claudius cells...
  79. ncbi Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2
    Noemi Marina-Garcia
    University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    J Immunol 180:4050-7. 2008
    ..Furthermore, the work provides evidence for distinct roles of Nod2 and Cryopyrin in the regulation of MDP-induced caspase-1 activation and IL-1beta secretion...
  80. ncbi Expression of neural connexins and pannexin1 in the hippocampus and inferior olive: a quantitative approach
    Svenja Weickert
    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, University Street 150, 44780 Bochum, Germany
    Brain Res Mol Brain Res 133:102-9. 2005
    ..We conclude that the analytical strategy shown here provides a technological solution to overcome the less sensitive and notoriously less specific analysis of connexin expression by in situ hybridization...

Research Grants4

  1. Calcium Buffering Mechanisms in Taste Cells
    Kathryn Medler; Fiscal Year: 2006
    ..This data will further our understanding about how taste cells generate a signal in response to a taste stimuli. [unreadable] [unreadable]..
  2. Functional Analysis of Inner Ear Gap Junctions
    Hong Bo Zhao; Fiscal Year: 2008
    ....
  3. EARLY HUSBANDRY INFLUENCES ON ADULT PHENOTYPE
    MICHAEL TORDOFF; Fiscal Year: 2009
    ..The results will lead to better environmental controls in future work and, asa direct consequence, easierand more rapid progress with genetic analyses. ..
  4. KCNRG gene as candidate tumor suppressor for CLL and MM
    Anna Baranova; Fiscal Year: 2005
    ..Common gene changes revealed by activation of KCNRG will be confirmed in Real-Time PCR experiments. ..