Pepc

Summary

Gene Symbol: Pepc
Description: peptidase C
Alias: Dip-1, Pep-3, Pep3, peptidase 3
Species: mouse

Top Publications

  1. ncbi Mapping and gene order of U1 small nuclear RNA, endogenous viral env sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3
    C Blatt
    Agouron Institute, La Jolla, California
    Somat Cell Mol Genet 14:133-42. 1988
  2. pmc Genetic mapping of a mouse chromosomal locus required for mink cell focus-forming virus replication
    C A Kozak
    J Virol 48:300-3. 1983
  3. pmc Cloning, characterization, and mapping of a murine promiscuous chemokine receptor gene: homolog of the human Duffy gene
    H Luo
    Genome Res 7:932-41. 1997
  4. ncbi En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis
    A L Joyner
    Department of Anatomy, University of California at San Francisco 94143
    Genes Dev 1:29-38. 1987
  5. pmc Tyrosine sulfation of native mouse Psgl-1 is required for optimal leukocyte rolling on P-selectin in vivo
    Andrew D Westmuckett
    Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 6:e20406. 2011
  6. ncbi Genetic analysis of nonhistone chromosomal protein inheritance in recombinant inbred mouse strains using two-dimensional electrophoresis
    L S Ramagli
    Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, Houston 77030
    Biochem Genet 28:123-36. 1990
  7. ncbi Gene mapping of the three subunits of the high affinity FcR for IgE to mouse chromosomes 1 and 19
    K Hupp
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892
    J Immunol 143:3787-91. 1989
  8. ncbi Mapping of the bcl-2 oncogene on mouse chromosome 1
    B A Mock
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892
    Cytogenet Cell Genet 47:11-5. 1988
  9. pmc Susceptibility of wild mouse cells to exogenous infection with xenotropic leukemia viruses: control by a single dominant locus on chromosome 1
    C A Kozak
    J Virol 55:690-5. 1985
  10. ncbi Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse
    R W Elliott
    In Vitro Cell Dev Biol 21:477-84. 1985

Scientific Experts

  • Franca Ronchese
  • Carlos Ocaña-Morgner
  • FILIP SWIRSKI
  • Mingfang Lu
  • R S Smith
  • Andrew D Westmuckett
  • D C Hughes
  • Eulogia Roman
  • Takanori So
  • Weihuan Wang
  • Jianhui Chang
  • Derek A Holmes
  • M E Mikucki
  • Sarah C Saunderson
  • Serine Avagyan
  • Georg F Weber
  • Hannah Rabenstein
  • Hiroyuki Nagashima
  • Haley Ataera
  • Frederick Masson
  • Claudia Nobrega
  • Michael Croft
  • Gerhard Wingender
  • Shengyi Sun
  • Xun Shang
  • Luisa de Andres-Aguayo
  • Ellen C Teng
  • Sreemanti Basu
  • Igor L Leskov
  • Shuxian Jiang
  • Norifumi Iijima
  • Owen M Siggs
  • Masahiro Kitano
  • Jacqueline Moebius
  • Carmela De Santo
  • Amanda Waterstrat
  • Silke Huber
  • Anna C Pulliam-Leath
  • B A Taylor
  • Alex Y Huang
  • David Wald
  • Rose Beck
  • Rémi Martin Laberge
  • Stephen Moreton
  • Grant Zimmerman
  • Wei Feng
  • Lijian Shao
  • Marco Demaria
  • Shuiliang Yu
  • Aimin Meng
  • Usha Ponnappan
  • Joseph Nthale
  • Yiwei Wang
  • Kimberly Krager
  • Daohong Zhou
  • Yi Luo
  • Xiaoyan Wang
  • Nukhet Aykin-Burns
  • Amad Awadallah
  • Wei Xin
  • Norman E Sharpless
  • Yingying Wang
  • Lan Zhou
  • Jay Myers
  • Judith Campisi
  • Krishnamurthy Janakiraman
  • Martin Hauer-Jensen
  • Xiaoran Huang
  • Sheng Ding
  • J J Skitzki
  • A D Luster
  • Eric Suto
  • A W Ku
  • Qinglin Ou
  • J Matsuzaki
  • Andrew C Chan
  • Patrick Caplazi
  • T F Gajewski
  • S S Evans
  • N B Gaulin
  • Wyne P Lee
  • J B Muhitch
  • Qian Gong
  • J G Frelinger
  • Hamish R C Smith
  • D T Fisher
  • K Odunsi
  • Matthias Nahrendorf
  • Hiroyasu Nakano
  • Clinton S Robbins

Detail Information

Publications107 found, 100 shown here

  1. ncbi Mapping and gene order of U1 small nuclear RNA, endogenous viral env sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3
    C Blatt
    Agouron Institute, La Jolla, California
    Somat Cell Mol Genet 14:133-42. 1988
    ..In situ hybridization to chromosome spreads confirmed the assignment of the Ulb small nuclear RNA (snRNA) gene cluster and the gamma-fibrinogen gene to the center of chromosome 3...
  2. pmc Genetic mapping of a mouse chromosomal locus required for mink cell focus-forming virus replication
    C A Kozak
    J Virol 48:300-3. 1983
    ....
  3. pmc Cloning, characterization, and mapping of a murine promiscuous chemokine receptor gene: homolog of the human Duffy gene
    H Luo
    Genome Res 7:932-41. 1997
    ..2-kb mRNA. The human erythroleukemia K562 cells, transfected with cDNA encoding the mouse Duffy-like protein and mouse erythrocytes, have the same chemokine binding profiles indicating that they contain the same protein...
  4. ncbi En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis
    A L Joyner
    Department of Anatomy, University of California at San Francisco 94143
    Genes Dev 1:29-38. 1987
    ..Both genes map in the vicinity of mutations that are known to cause abnormalities during development...
  5. pmc Tyrosine sulfation of native mouse Psgl-1 is required for optimal leukocyte rolling on P-selectin in vivo
    Andrew D Westmuckett
    Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 6:e20406. 2011
    ..Here we test the function of native Psgl-1 expressed in leukocytes lacking endogenous tyrosylprotein sulfotransferase (TPST) activity...
  6. ncbi Genetic analysis of nonhistone chromosomal protein inheritance in recombinant inbred mouse strains using two-dimensional electrophoresis
    L S Ramagli
    Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, Houston 77030
    Biochem Genet 28:123-36. 1990
    ..These 16 NHCP genetic marker inheritance differences detected in RIs add to the 23 previously established genetic marker differences between the progenitors...
  7. ncbi Gene mapping of the three subunits of the high affinity FcR for IgE to mouse chromosomes 1 and 19
    K Hupp
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892
    J Immunol 143:3787-91. 1989
    ..The close association of the genes for Fc epsilon RI alpha, FC gamma RII, and their shared gamma subunits raises interesting implications regarding coordinate regulation of gene expression...
  8. ncbi Mapping of the bcl-2 oncogene on mouse chromosome 1
    B A Mock
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892
    Cytogenet Cell Genet 47:11-5. 1988
    ..The co-segregation of bcl-2 alleles with allelic forms of two other chromosome 1 loci, Ren-1,2 and Spna-1, in a set of back-cross progeny, positions bcl-2 7.8 cM centromeric from Ren-1,2...
  9. pmc Susceptibility of wild mouse cells to exogenous infection with xenotropic leukemia viruses: control by a single dominant locus on chromosome 1
    C A Kozak
    J Virol 55:690-5. 1985
    ....
  10. ncbi Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse
    R W Elliott
    In Vitro Cell Dev Biol 21:477-84. 1985
    ..4 +/- 3.2 cM distal to the Pep-3 locus. There is no evidence in the mouse for pseudogenes for these proteins...
  11. pmc Genetics of susceptibility for radiation-induced leukemia. Mapping of genes involved to chromosomes 1, 2, and 4, and implications for a viral etiology in the disease
    D Meruelo
    J Exp Med 154:1201-11. 1981
    ..An explanation for tissue-specific activation of endogenous viruses is that activation of the virus in question is dependent on differentiation-specific steps...
  12. ncbi Genetics of alkaline phosphatase of the small intestine of the house mouser (Mus musculus)
    F H Wilcox
    Biochem Genet 21:641-52. 1983
    ....
  13. ncbi Preferential but nonexclusive expression of macromolecular antigens on B-lineage cells
    M P Scheid
    Immunol Rev 69:141-59. 1982
  14. ncbi Upg-2: a urinary pepsinogen variant located on chromosome 1 of the mouse
    J M Szymura
    Biochem Genet 20:1211-9. 1982
    ..Typing of recombinant inbred strains suggests that the location of the Upg-2 locus is on chromosome 1, in the vicinity of loci coding for other peptidases, namely, Pep-2 and Rnr, and of the Acf-1 locus...
  15. ncbi Localization of the inhibin beta B gene on mouse chromosome 1
    W P Lafuse
    Department of Medical Microbiology and Immunology, Ohio State University, Columbus 43210
    Mamm Genome 4:399-400. 1993
  16. ncbi FISH mapping of three ammonia metabolism genes (Glul, Cps1, Glud1) in rat, and the chromosomal localization of GLUL in human and Cps1 in mouse
    K Helou
    Department of Genetics, Göteborg University Medicinareg 9C, S 413 90 Göteborg, Sweden
    Mamm Genome 8:362-4. 1997
  17. pmc Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia
    Anna C Pulliam-Leath
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 116:2915-20. 2010
    ..Importantly, this model closely recapitulates the phenotypes found in FA patients and may be useful as a preclinical platform to evaluate the molecular pathogenesis of spontaneous bone marrow failure, MDS and AML in FA...
  18. doi Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2
    Silke Huber
    Institute for Immunology, Ludwig Maximilians University, Munich, Germany
    Blood 116:3311-20. 2010
    ..In vivo blockade of PD-L2 during N brasiliensis infection caused an enhanced Th2 response in the lung, indicating that AAM inhibit Th2 cells by expression of PD-L2...
  19. pmc The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow
    Owen M Siggs
    Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 12:434-40. 2011
    ..Our data establish an essential, cell-autonomous and context-sensitive function for ATP11C, a putative aminophospholipid flippase, in B cell development...
  20. pmc R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization
    Xun Shang
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:24068-78. 2011
    ..These results indicate that R-Ras is a critical regulator of Rac signaling required for HPC migration, homing, and mobilization...
  21. pmc T cells home to the thymus and control infection
    Claudia Nobrega
    Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710 057 Braga, Portugal
    J Immunol 190:1646-58. 2013
    ..Maintaining a functional thymic environment is essential to maintain T cell differentiation and prevent the emergence of central tolerance to the invading pathogens...
  22. doi SWAP-70 restricts spontaneous maturation of dendritic cells
    Carlos Ocaña-Morgner
    Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, D 01307 Dresden, Germany
    J Immunol 190:5545-58. 2013
    ..Thus, SWAP-70 deficiency reveals two pathways that contribute to spontaneous maturation of DCs...
  23. pmc Persistently active microbial molecules prolong innate immune tolerance in vivo
    Mingfang Lu
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 9:e1003339. 2013
    ..Measures that disable microbial molecules might enhance resolution of tissue inflammation and help restore innate defenses in individuals recovering from many different infectious diseases...
  24. doi The control of CD8+ T cell responses is preserved in perforin-deficient mice and released by depletion of CD4+CD25+ regulatory T cells
    Haley Ataera
    2 Entrance 7 Kelburn Parade, 6012 Kelburn, Wellington, New Zealand
    J Leukoc Biol 94:825-33. 2013
    ..These data suggest that perforin expression is not required for normal immune regulation in these models of in vivo CD8(+) T cell responses induced by immunization with OVA and α-GalCer or DC-OVA. ..
  25. pmc CD169 mediates the capture of exosomes in spleen and lymph node
    Sarah C Saunderson
    Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, Dunedin, Otago, New Zealand and
    Blood 123:208-16. 2014
    ..Interestingly, CD169(-/-) mice demonstrated an enhanced response to antigen-pulsed exosomes. This is the first report of a role for CD169 in the capture of exosomes and its potential to mediate the immune response to exosomal antigen. ..
  26. doi Differential kinetics of antigen dependency of CD4+ and CD8+ T cells
    Hannah Rabenstein
    Institute for Immunology, Ludwig Maximilians University Munich, 80336 Munich, Germany
    J Immunol 192:3507-17. 2014
    ..In summary, our data demonstrate that CD4+ T cells require continuous stimulation for clonal expansion, whereas CD8+ T cells can divide following a much shorter TCR signal...
  27. pmc The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6
    Hiroyuki Nagashima
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Nat Immunol 15:449-56. 2014
    ..Our results identify TRAF5 as a negative regulator of the IL-6 receptor signaling pathway that limits the induction of proinflammatory CD4(+) T cells that require IL-6 for their development. ..
  28. pmc Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis
    Georg F Weber
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 Department of Visceral, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, 01307 Dresden, Germany
    J Exp Med 211:1243-56. 2014
    ..The study describes a previously unrecognized GM-CSF-IgM axis and positions IRA B cells as orchestrators of protective IgM immunity. ..
  29. pmc Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency
    Serine Avagyan
    Morgan Stanley Children s Hospital of New York Presbyterian, Department of Pediatrics, Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Research Center
    Blood 124:1622-5. 2014
    ....
  30. pmc Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling
    Derek A Holmes
    Department of Immunology, Department of Translational Immunology, and Department of Pathology, Genentech, Inc, South San Francisco, CA 94080
    J Exp Med 212:1081-93. 2015
    ..As SLE patients carrying the PTPN22(C1858T) risk variant have higher serum IFN-α activity, these data provide a molecular basis for how type I IFNs and PTPN22 may cooperate to contribute to lupus-associated cytopenias. ..
  31. pmc Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints
    M E Mikucki
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Nat Commun 6:7458. 2015
    ..Taken together, these studies identify CXCR3-mediated trafficking at the tumour vascular interface as a critical checkpoint to effective T-cell-based cancer immunotherapy. ..
  32. pmc Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
    Jianhui Chang
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Nat Med 22:78-83. 2016
    ..Thus, senolytic drugs may represent a new class of radiation mitigators and anti-aging agents. ..
  33. pmc Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function
    Weihuan Wang
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio
    Cancer Res 76:1641-52. 2016
    ..Collectively, our findings suggest that therapeutically targeting the leukemia-infiltrated hematopoietic niche may restore HSPC homeostasis and improve the outcome of ALL patients...
  34. pmc NAD(P)H oxidase and eNOS play differential roles in cytomegalovirus infection-induced microvascular dysfunction
    Igor L Leskov
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Free Radic Biol Med 51:2300-8. 2011
    ....
  35. pmc Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses
    Sreemanti Basu
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    J Immunol 187:5720-32. 2011
    ..This study demonstrates that CB2 positively regulates T-independent immune responses by controlling the localization and positioning of MZ lineage cells to the MZ...
  36. pmc Neutrophilic granulocytes modulate invariant NKT cell function in mice and humans
    Gerhard Wingender
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 188:3000-8. 2012
    ..Our data reveal a novel regulatory axis whereby neutrophils reduce iNKT cell responses, which may be important in shaping the extent of inflammation...
  37. pmc The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue
    Shengyi Sun
    Graduate Program in Biochemistry, Molecular, and Cell Biology, Cornell University, Ithaca, New York, USA
    Diabetes 61:1471-8. 2012
    ..The nature of the inflammasome-activating danger signal(s) in adipose tissue in obesity remains to be characterized...
  38. pmc Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation
    Frederick Masson
    Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia
    J Immunol 190:4585-94. 2013
    ..Our findings reveal that the Id2/E2A axis orchestrates T cell differentiation through the induction or repression of downstream transcription factors essential for effector and memory T cell differentiation...
  39. ncbi Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2
    U Francke
    Cytogenet Cell Genet 19:57-84. 1977
    ..Striking examples of norandom segregation of mouse chromosomes were observed in these hybrids with preferential retention of 15 and segregation of 11 and the Y chromosome...
  40. ncbi Genetic mapping of xenotropic leukemia virus-inducing loci in two mouse strains
    C Kozak
    Science 199:1448-9. 1978
    ..In both strains, the virus-inducing loci are on chromosome 1, linked to the Dip-1/isozyme locus, but the two may not be at allelic sites...
  41. ncbi Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids
    C A Kozak
    Somatic Cell Genet 3:121-33. 1977
  42. ncbi Genetic mapping of the ecotropic murine leukemia virus-inducing locus of BALB/c mouse to chromosome 5
    C A Kozak
    Science 204:69-71. 1979
    ..These studies provide further evidence that endogenous ecotropic viruses represent viral genomes inserted at different chromosomal sites in the various mouse strains...
  43. pmc Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse
    C M Wilson
    Proc Natl Acad Sci U S A 75:5623-6. 1978
    ..Documentation that a single gene can have major effects on renin in the submaxillary gland of the mouse implies that single gene differences might explain known variations in renin in other species...
  44. pmc Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse
    D J Bradley
    Clin Exp Immunol 37:7-14. 1979
    ..The data indicate that the gene order is centromere-Lsh-Id-1-ln-Dip-1. The estimated recombination frequency between Lsh and Id-1 is 0.12 +/- 0.04. This mapping is away from the known histocompatibility loci...
  45. ncbi Linkage of the locus for conversion of albumin (Acf-1) in the house mouse, Mus musculus
    F H Wilcox
    Biochem Genet 17:159-62. 1979
    ..The linkage of the locus for conversion of albumin (Acf-1) has been established on chromosome 1 with the following gene order and recombination percentages: Id-1 19.3 +/- 5.2% Acf-1 4.2 +/- 1.7% Dip-1 18.4 +/- 4.2% Lp...
  46. ncbi Genetics, ontogeny, and testosterone inducibility of aldehyde oxidase isozymes in the mouse: evidence for two genetic loci (Aox-I and Aox-2) closely linked on chromosome 1
    R S Holmes
    Biochem Genet 17:517-27. 1979
    ..Both isozymes were significantly reduced in activity by castration of adult males and increased following testosterone administration to castrated males and normal female mice...
  47. ncbi Mapping the adrenal lipid depletion gene of the AKR/J mouse strain
    B A Taylor
    Genet Res 26:307-12. 1975
  48. ncbi Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome
    C Kozak
    Somatic Cell Genet 1:371-82. 1975
    ..All other isozymes examined segregated independently of one another...
  49. ncbi The gene for the alpha 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse chromosome 1
    H Chin
    Laboratory of Molecular Biology, NINDS, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 14:1089-91. 1992
    ..Analysis of the progeny of an inbred strain cross-positioned Cchl1a3 1.3 cM proximal to the Pep-3 locus on Chr 1...
  50. ncbi Dominant hemimelia and En-1 on mouse chromosome 1 are not allelic
    M Higgins
    MRC Human Genetics Unit, Edinburgh, UK
    Genet Res 60:53-60. 1992
    ..The likely gene order and recombination frequencies of these loci are: ln (5.2 +/- 0.9) Emv-17 (1.1 +/- 0.4) Dh (0.7 +/- 0.4) En-1 (3.0 +/- 0.7) Pep-3. This shows that Dh is not a mutant allele of En-1...
  51. ncbi Analysis of Ly5 chromosome 1 position using allelic differences and recombinant inbred mice
    S L Zebedee
    La Jolla Biological Laboratories, California
    Eur J Immunogenet 18:155-63. 1991
    ..Placement of the Ly5 gene with respect to other characterized markers of mouse chromosome 1 for these recombinant inbred mouse strains shows a gene order of Idh-1:Ity:Pep3:[Ly5, Cfh].
  52. ncbi Segregation of genes from donor strain during the production of recombinant congenic strains
    L F van Zutphen
    Department of Laboratory Animal Science, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    Lab Anim 25:193-7. 1991
    ..The data obtained do not significantly deviate from the expected pattern, thus supporting the validity of the concept of RCS...
  53. ncbi A genetic map of mouse chromosome 1 near the Lsh-Ity-Bcg disease resistance locus
    B Mock
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 7:57-64. 1990
    ..This multipoint linkage analysis of chromosome 1 surrounding the Lsh-Ity-Bcg locus provides a basis for the eventual isolation of the disease gene...
  54. ncbi The human MyoD1 (MYF3) gene maps on the short arm of chromosome 11 but is not associated with the WAGR locus or the region for the Beckwith-Wiedemann syndrome
    M Gessler
    Genetics Division, Children s Hospital, Boston, MA 02115
    Hum Genet 86:135-8. 1990
    ..5 related to the Beckwith-Wiedemann syndrome. Subregional mapping by in situ hybridization with an myf3 specific probe shows that the gene resides at the chromosomal band 11p14, possibly at 11p14.3...
  55. ncbi The major histocompatibility complex-restricted antigen receptor on T cells: the genetics of expression of an allotype
    N W Roehm
    J Immunol 135:2176-82. 1985
    ..The identity of the other, as yet unmapped locus is unknown. KJ16-133 was used to show that T cell receptor gene products are expressed in a manner consistent with allelic exclusion...
  56. ncbi Characterization and chromosomal distribution of endogenous mouse mammary tumor viruses of European mouse strains STS/A and GR/A
    R Michalides
    Virology 142:278-90. 1985
    ..R. Callahan, D. Gallahan, and Ch. Kozak (1984), J. Virol. 49, 1005-1008). GR and GR.Mtv-2 furthermore contain two incomplete MMTV proviral elements, one of which is also present in STS/A...
  57. ncbi Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage
    M Potter
    Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20892
    Genomics 2:257-62. 1988
    ....
  58. ncbi Genetics and development of ocular oxidases in the mouse: evidence for a new locus (Eox-1) closely linked with the aldehyde oxidase loci on chromosome 1
    M Hintz
    Division of Science and Technology, Griffith University, Brisbane, Australia
    Anim Genet 19:227-36. 1988
    ..These results support the proposal that ocular oxidases are distinct from the major liver AOXs in this organism...
  59. ncbi Establishment of a molecular genetic map of distal mouse chromosome 1: further definition of a conserved linkage group syntenic with human chromosome 1q
    M F Seldin
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 2:48-56. 1988
    ..These results suggest that mouse gene analyses may help in detailed mapping of human genes within such a syntenic group...
  60. ncbi Juvenile spermatogonial depletion (jsd): a genetic defect of germ cell proliferation of male mice
    W G Beamer
    Jackson Laboratory, Bar Harbor, Maine 04609
    Biol Reprod 38:899-908. 1988
    ..We hypothesize the jsd/jsd male may be deficient in proliferative signals from Sertoli cells that are needed for spermatogenesis...
  61. ncbi Identification of Dh/+ and Dh/Dh embryos through close linkage of Dh and peptidase-3
    L B Holmes
    Teratology 34:353-7. 1986
    ..This technique makes it possible to identify and to study the limb malformations and other phenotypic effects of Dh during their development and before the limb deformity is visible...
  62. ncbi Genetic studies on resistant and susceptibility genes controlling the mouse cornea to infection with Pseudomonas aeruginosa
    R S Berk
    Department of Immunology Microbiology, Wayne State University School of Medicine, Detroit, Mich
    Antibiot Chemother 39:83-91. 1987
  63. ncbi The mouse liver aldehyde oxidase locus (Aox)
    J G Watson
    Biochem Genet 6:195-204. 1972
  64. ncbi Variations among sublines of inbred AKR mice
    R T Acton
    Nat New Biol 245:8-10. 1973
  65. ncbi Linkage of isozyyme loci in the mouse: phosphoglucomutase-2 (Pgm-2), mitochondrial NADP malate dehydrogenase (Mod-2), and dipeptidase-1 (Dip-1)
    V M Chapman
    Biochem Genet 5:101-10. 1971
  66. ncbi Spectrin deficient inherited hemolytic anemias in the mouse: characterization by spectrin synthesis and mRNA activity in reticulocytes
    D M Bodine
    Cell 37:721-9. 1984
    ..Analysis of spectrin synthesis in mice homozygous and heterozygous for several alleles of sph indicates that the sph locus is the structural gene locus for alpha spectrin. We have mapped the sph locus to mouse Chromosome 1...
  67. ncbi Genetic and functional relationships of the retroviral and lymphocyte alloantigen loci on mouse chromosome 1
    C A Kozak
    Immunogenetics 19:163-8. 1984
  68. pmc A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites
    M Potter
    Infect Immun 40:1234-5. 1983
    ..BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b mice were resistant to in vivo infections by Salmonella typhimurium, Mycobacterium bovis, and Leishmania donovani...
  69. pmc Evolution and variation of renin genes in mice
    D P Dickinson
    Genetics 108:651-67. 1984
    ..spretus (2.75-5.5 million yr ago). This conclusion is in agreement with a prior estimate based upon comparative sequence analysis of Ren-1 and Ren-2 from inbred laboratory mice...
  70. ncbi Genetic and serologic re-evaluation of LyM-1 antigen specified by a gene closely linked to Mls: establishment of LyM-1 antigen of the mouse
    H Sato
    J Immunogenet 8:27-40. 1981
    ..2 serum under the condition in which Lyb-2.1 is not involved in analysis. The strain distribution of LyM-1 antigen, its preferential expression on B lymphocytes and close genetic linkage of LyM-1 to Mls have been established...
  71. pmc A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice
    J B Roths
    J Exp Med 159:1-20. 1984
    ....
  72. pmc Position on mouse chromosome 1 of a gene that controls resistance to Salmonella typhimurium
    B A Taylor
    Infect Immun 36:1257-60. 1982
    ..The results of a five-point backcross clearly showed that the correct gene order on chromosome 1 is fz-Idh-1-Ity-ln-Pep-3...
  73. ncbi Location of a gene controlling electrophoretic variation in mouse gamma-crystallins
    L C Skow
    Exp Eye Res 34:509-16. 1982
  74. ncbi Cloning and expression of the mouse laminin gamma 2 (B2t) chain, a subunit of epithelial cell laminin
    S Sugiyama
    Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892
    Eur J Biochem 228:120-8. 1995
    ..This protein complex is characteristic of the kalinin (nicein/epiligrin) complex, and provides further evidence that these proteins are identical and that the gamma 2 chain is the subunit of the epithelial-cell-specific laminin...
  75. ncbi Chromosomal assignment of three novel mouse genes expressed in testicular cells
    L Lemaire
    Institut fur Genetik, Heinrich Heine Universitat, Dusseldorf, Federal Republic of Germany
    Genomics 21:409-14. 1994
    ....
  76. ncbi New mouse primary retinal degeneration (rd-3)
    B Chang
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 16:45-9. 1993
    ..5 cM distal to Akp-1. Homology mapping suggests that the homologous human locus should be on chromosome 1q...
  77. ncbi Cloning and expression in Xenopus oocytes of a mouse homologue of the human acylcoenzyme A: cholesterol acyltransferase and its potential role in metabolism of oxidized LDL
    S Green
    Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    Biochem Biophys Res Commun 218:924-9. 1996
    ..Injection of ACAT mRNA into oocytes induced specific binding of OxLDL. ACAT is expressed in mouse macrophages as a approximately 3.6 kB transcript and the expression is upregulated in human THP-1 cells treated with PMA...
  78. ncbi Lop12, a mutation in mouse Crygd causing lens opacity similar to human Coppock cataract
    R S Smith
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 63:314-20. 2000
    ..It is predicted that the defective gene product alters protein folding of the gamma-crystallin(s) and results in lens opacity...
  79. ncbi Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment
    A Janowska-Wieczorek
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Blood 98:3143-9. 2001
    ..These findings indicate a new role for PMPs in stem cell transplantation and may have clinical implications for the optimization of transplantations...
  80. ncbi Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells
    Kimberly S Schluns
    Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    J Immunol 168:4827-31. 2002
    ..IL-15Ralpha expression was low on naive CD8 T cells, up-regulated on Ag-specific effector cells, and sustained on memory cells. Thus, IL-15 was important for the generation and the subsequent maintenance of antiviral memory CD8 T cells...
  81. ncbi A new assay method for late CFU-S formation and long-term reconstituting activity using a small number of pluripotent hemopoietic stem cells
    Guoxiang Yang
    First Department of Pathology, Transplantation Center, and Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan
    Stem Cells 20:241-8. 2002
    ..Moreover, donor-derived multilineage cells were detected in all the hematolymphoid organs of the recipient mice. This new assay method using a small number of cells would be of great advantage for clarifying which cells are truly P-HSCs...
  82. pmc Glutamate oxaloacetate transaminase (got) genetics in the mouse: polymorphism of got-1
    V M Chapman
    Department of Biology, Kline Biology Tower, Yale University, New Haven, Connecticut 06520
    Genetics 70:299-305. 1972
    ..Our results demonstrate the utility of sampling Mus from diverse populations to extend the repertoire of polymorphic loci and the genetic linkage map...
  83. pmc Congenic interval of CD45/Ly-5 congenic mice contains multiple genes that may influence hematopoietic stem cell engraftment
    Amanda Waterstrat
    Department of Biological Sciences, Eastern Kentucky University, Richmond, USA
    Blood 115:408-17. 2010
    The B6.SJL-Ptprc(d)Pep3(b)/BoyJ (B6...
  84. pmc Cutting edge: Hematopoietic-derived APCs select regulatory T cells in thymus
    Eulogia Roman
    Department of Immunology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 185:3819-23. 2010
    ..In addition, Treg selection requires the TCR signal and CD28 costimulation presented in cis on the same APC type in vivo. This study demonstrates a new role, to our knowledge, for HCs in the development of Tregs in thymus...
  85. pmc Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A
    Carmela De Santo
    Medical Research Council Human Immunology Unit, Nuffield Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    Nat Immunol 11:1039-46. 2010
    ....
  86. pmc Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization
    Shuxian Jiang
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Blood 117:827-38. 2011
    ..Thus, CB₂ agonists may be therapeutically applied in clinical conditions, such as bone marrow transplantation...
  87. doi Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice
    Jacqueline Moebius
    Division of Immunology, Department of Biology, Constance University, Konstanz, Germany
    Eur J Immunol 40:3439-49. 2010
    ..Therefore, the immunoproteasome may qualify as a potential new target for the suppression of undesired proinflammatory T-cell responses...
  88. pmc Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue
    Norifumi Iijima
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:284-9. 2011
    ....
  89. pmc Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells
    Takanori So
    Divisions of Molecular Immunology and Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:2903-8. 2011
    ..Thus, by recruiting TCR-related intracellular molecules into the TRAF2 complex, OX40 provides the T cell with a high level of NF-κB activity needed for longevity...
  90. doi Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice
    Luisa de Andres-Aguayo
    Differentiation and Cancer Program, Center for Genomic Regulation and UPF, Barcelona, Spain
    Blood 118:554-64. 2011
    ..Our data indicate that Msi2 maintains the stem cell compartment mainly by regulating the proliferation of primitive progenitors downstream of LT-HSCs...
  91. doi Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity
    Masahiro Kitano
    Research Unit for Immunodynamics, RIKEN, Research Center for Allergy and Immunology, Yokohama, 230 0045, Japan
    Immunity 34:961-72. 2011
    ..These results clarify the role of Bcl6 in pre-GC B cell dynamics and highlight the modulation of Bcl6 expression in Tfh cells that persist in the late phase of the antibody response...
  92. pmc A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation
    Ellen C Teng
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27708, USA
    J Leukoc Biol 90:897-909. 2011
    ..Collectively, our results reveal a novel role for CaMKK2 as an inhibitor of granulocytic fate commitment and differentiation in early myeloid progenitors...
  93. ncbi The AXB and BXA set of recombinant inbred mouse strains
    J D Marshall
    Jackson Laboratory, Bar Harbor, Maine 04609 1500
    Mamm Genome 3:669-80. 1992
    ..Thus, the AXB and BXA set of RI strains will be useful in the genetic analysis of several complex diseases...
  94. pmc Sequence and organization of the mouse poly (ADP-ribose) polymerase gene
    K Huppi
    Laboratory of Genetics, NCI, Bethesda, MD 20892
    Nucleic Acids Res 17:3387-401. 1989
    ..Furthermore, ADPRP is closely associated with the autoimmune locus gld (generalized lymphadenopathy)...
  95. ncbi A mouse linkage testing stock possessing multiple copies of the endogenous ecotropic murine leukemia virus genome
    B A Taylor
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 5:221-32. 1989
    ..Ways of further improving the MEV stock are discussed. The location of the Myb proto-oncogene is defined relative to Sl and one of the C58/J proviruses on chromosome 10...
  96. pmc Chromosomal localization of Emv-16 and Emv-17, two closely linked ecotropic proviruses of RF/J mice
    A M Buchberg
    J Virol 60:1175-8. 1986
    ....
  97. ncbi BALB.D2-Mlsa--a new congenic mouse strain
    H Festenstein
    Transplantation 37:322-4. 1984
  98. pmc Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains
    C A Kozak
    J Exp Med 152:219-28. 1980
    ..An analysis of the hamster X mouse somatic cell hybrids indicated that chromosome 1, alone, was sufficient for virus induction...
  99. ncbi Characterization and chromosomal location of endogenous mouse mammary tumor virus loci in GR, NFS, and DBA mice
    J I MacInnes
    Virology 132:12-25. 1984
    ....
  100. ncbi Mouse alloantigen system Ly-m22 predominantly expressed on T lymphocytes and controlled by a gene linked to M1s region on chromosome 1
    N Tada
    Hybridoma 2:29-38. 1983
    ..Analysis of BXD and SWXL recombinant inbred strains revealed close linkage between Ly-m22 and Ltw-4 loci on chromosome 1. The estimated recombination frequency is 0.027 +/- 0.081...