Ppargc1a

Summary

Gene Symbol: Ppargc1a
Description: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Alias: A830037N07Rik, Gm11133, PGC-1, PPARGC-1-alpha, Pgc-1alpha, Pgc1, Pgco1, Ppargc1, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PPAR-gamma coactivator 1-alpha
Species: mouse

Top Publications

  1. ncbi Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism
    James Rhee
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    J Biol Chem 281:14683-90. 2006
  2. pmc Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice
    Shawn C Burgess
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    J Biol Chem 281:19000-8. 2006
  3. pmc Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha
    Zoltan Arany
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:10086-91. 2006
  4. pmc Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells
    Zhidan Wu
    Diabetes and Metabolism Disease Area, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:14379-84. 2006
  5. doi Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity
    Serge Summermatter
    Biozentrum, Division of Pharmacology Neurobiology, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Biochem Biophys Res Commun 408:180-5. 2011
  6. ncbi Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 418:797-801. 2002
  7. ncbi Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:30014-21. 2007
  8. ncbi Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway
    Takayuki Akimoto
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:19587-93. 2005
  9. doi Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake
    Jennifer A Calvo
    Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    J Appl Physiol (1985) 104:1304-12. 2008
  10. pmc PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism
    Adam R Wende
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 25:10684-94. 2005

Scientific Experts

Detail Information

Publications141 found, 100 shown here

  1. ncbi Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism
    James Rhee
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    J Biol Chem 281:14683-90. 2006
    ..These data point to a crucial role for the PGC-1alpha/HNF4alpha partnership in hepatic lipoprotein metabolism...
  2. pmc Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice
    Shawn C Burgess
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    J Biol Chem 281:19000-8. 2006
    ....
  3. pmc Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha
    Zoltan Arany
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:10086-91. 2006
    ..Moreover, the data suggest that elevating PGC-1alpha activity may have therapeutic potential in the treatment of heart failure...
  4. pmc Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells
    Zhidan Wu
    Diabetes and Metabolism Disease Area, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:14379-84. 2006
    ..Our results, together with previous findings, strongly suggest that TORCs play a key role in linking these external signals to the transcriptional program of adaptive mitochondrial biogenesis by activating PGC-1alpha gene transcription...
  5. doi Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity
    Serge Summermatter
    Biozentrum, Division of Pharmacology Neurobiology, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Biochem Biophys Res Commun 408:180-5. 2011
    ....
  6. ncbi Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 418:797-801. 2002
    ..These data indicate that PGC-1 alpha is a principal factor regulating muscle fibre type determination...
  7. ncbi Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:30014-21. 2007
    ..Our data demonstrate a critical role for PGC-1alpha in maintenance of normal fiber type composition and of muscle fiber integrity following exertion...
  8. ncbi Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway
    Takayuki Akimoto
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:19587-93. 2005
    ..These findings suggest that contractile activity-induced activation of the p38 MAPK pathway promotes Pgc-1alpha gene expression and skeletal muscle adaptation...
  9. doi Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake
    Jennifer A Calvo
    Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    J Appl Physiol (1985) 104:1304-12. 2008
    ..Thus this study demonstrates that upregulation of PGC-1alpha in muscle in vivo is sufficient to greatly improve exercise performance under various exercise paradigms as well as increase peak oxygen uptake...
  10. pmc PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism
    Adam R Wende
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 25:10684-94. 2005
    ....
  11. pmc The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex
    Jun Wu
    Dana Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 13:160-9. 2011
    ..These findings suggest that modulation of the UPR through PGC1α represents an alternative avenue to improve skeletal muscle function and achieve metabolic benefits.
  12. pmc PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 21:770-83. 2007
    ..Thus, control of PGC-1alpha levels in skeletal muscle could represent a novel avenue to prevent or treat DMD...
  13. pmc Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 117:3463-74. 2007
    ..These data clearly illustrate a causal role for muscle PGC-1alpha in maintenance of glucose homeostasis and highlight an unexpected cytokine-mediated crosstalk between skeletal muscle and pancreatic islets...
  14. ncbi CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    S Herzig
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nature 413:179-83. 2001
    ..Fasting hyperglycaemia is strongly correlated with type II diabetes, so our results suggest that the activation of PGC-1 by CREB in liver contributes importantly to the pathogenesis of this disease...
  15. pmc NT-PGC-1α protein is sufficient to link β3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis
    Ji Suk Chang
    Laboratory of Nutrient Sensing and Adipocyte Signaling, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 287:9100-11. 2012
    ..Furthermore, the transcriptional shift from exon 1a to 1b supports isoform-specific roles for NT-PGC-1α in basal and adaptive thermogenesis...
  16. pmc PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis
    Teresa C Leone
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 3:e101. 2005
    ..Lastly, vacuolar lesions were detected in the central nervous system of PGC-1alpha(-/-) mice. These results demonstrate that PGC-1alpha is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life...
  17. pmc Peroxisome-proliferator-activated receptor gamma coactivator 1 α contributes to dysmyelination in experimental models of Huntington's disease
    Zhongmin Xiang
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 31:9544-53. 2011
    The peroxisome-proliferator-activated receptor gamma coactivator 1 α (PGC1α) has been implicated in the pathogenesis of several neurodegenerative disorders, including Huntington's disease (HD)...
  18. pmc Transcriptional control of brown fat determination by PRDM16
    Patrick Seale
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Cell Metab 6:38-54. 2007
    ..PRDM16 activates brown fat cell identity at least in part by simultaneously activating PGC-1alpha and PGC-1beta through direct protein binding. These data indicate that PRDM16 can control the determination of brown fat fate...
  19. ncbi Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:505-15. 2005
    ..These data show that PGC-1alpha links nutritional status to heme biosynthesis and acute hepatic porphyria...
  20. pmc PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
    Marco Sandri
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16260-5. 2006
    ..Thus, the high levels of PGC-1alpha in dark and exercising muscles can explain their resistance to atrophy, and the rapid fall in PGC-1alpha during atrophy should enhance the FoxO-dependent loss of muscle mass...
  21. pmc Parvalbumin deficiency and GABAergic dysfunction in mice lacking PGC-1alpha
    Elizabeth K Lucas
    Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 30:7227-35. 2010
    ..Together these findings indicate that PGC-1alpha is a novel regulator of interneuron gene expression and function and a potential therapeutic target for neurological disorders associated with interneuron dysfunction...
  22. pmc Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9
    Yasuhiko Kawakami
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:2414-9. 2005
    ..Together, our results suggest a transcriptional mechanism for chondrogenesis that is coordinated by PGC-1alpha...
  23. ncbi Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
    Libin Cui
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegeneration, Charlestown, MA 02129 USA
    Cell 127:59-69. 2006
    ..These studies suggest a key role for PGC-1alpha in the control of energy metabolism in the early stages of HD pathogenesis...
  24. ncbi PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle
    Lotte Leick
    Centre of Inflammation and Metabolism, and Copenhagen Muscle Research Centre, Department of Molecular Biology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 294:E463-74. 2008
    ..However, PGC-1alpha is not mandatory for training-induced increases in ALAS1, COXI, and cyt c expression, showing that factors other than PGC-1alpha can exert these adaptations...
  25. pmc p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice
    Andrew R Pogozelski
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 4:e7934. 2009
    ..These findings provide direct evidence for an obligated role of p38gamma MAPK-PGC-1alpha regulatory axis in endurance exercise-induced metabolic adaptation, but not contractile adaptation, in skeletal muscle...
  26. pmc Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 19:3190-205. 2010
    ....
  27. doi The importance of PGC-1α in contractile activity-induced mitochondrial adaptations
    Giulia Uguccioni
    York University, Toronto, ON, Canada
    Am J Physiol Endocrinol Metab 300:E361-71. 2011
    ....
  28. pmc Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase
    Yaniv Lustig
    Department of Cell Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 25:1232-44. 2011
    ..These data illustrate that S6 kinase can modify PGC-1α and thus allow molecular dissection of its functions, providing metabolic flexibility needed for dietary adaptation...
  29. ncbi Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator
    Xinghai Li
    Institute for Diabetes, Obesity and Metabolism, Cox Institute, University of Pennsylvania School of Medicine and the Howard Hughes Medical Institute, Philadelphia, Pennsylvania 19104, USA
    Nature 447:1012-6. 2007
    ..These results define a mechanism by which insulin controls lipid catabolism in the liver and suggest a novel site for therapy in type 2 diabetes mellitus...
  30. pmc Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression
    Jennifer L Estall
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA, USA
    Diabetes 58:1499-508. 2009
    ..However, how moderate changes in PGC-1alpha activity affect metabolism and energy homeostasis has yet to be determined...
  31. ncbi Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 120:261-73. 2005
    ..These data suggest a mechanism through which dietary saturated fats can stimulate hyperlipidemia and atherogenesis...
  32. pmc Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha
    YuBin Zhang
    Laboratory of Nutrient Sensing and Adipocyte Signaling, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 284:32813-26. 2009
    ..Therefore, NT-PGC-1alpha is a co-expressed, previously unrecognized form of PGC-1alpha with functions that are both unique from and complementary to PGC-1alpha...
  33. pmc The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle
    Jessica Chinsomboon
    Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 106:21401-6. 2009
    ..These data demonstrate that beta-adrenergic stimulation of a PGC-1alpha/ERRalpha/VEGF axis mediates exercise-induced angiogenesis in skeletal muscle...
  34. ncbi AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1
    Woo Je Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 340:291-5. 2006
    ..These data suggest that a novel transcriptional regulatory mechanism involving PPARalpha and PGC-1 exists that is responsible for long-term stimulation of fatty acid oxidation in skeletal muscle by AICAR...
  35. pmc Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle
    Janice M Huss
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 24:9079-91. 2004
    ..We conclude that ERRalpha serves as a critical nodal point in the regulatory circuitry downstream of PGC-1alpha to direct the transcription of genes involved in mitochondrial energy-producing pathways in cardiac and skeletal muscle...
  36. pmc Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex
    Shingo Kajimura
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 22:1397-409. 2008
    ..These data show that the regulated docking of the CtBP proteins on PRDM16 controls the brown and white fat-selective gene programs...
  37. pmc Neuronal inactivation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) protects mice from diet-induced obesity and leads to degenerative lesions
    Di Ma
    Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:39087-95. 2010
    ..Our results also implicate CaMKIIα-positive neurons as an important part of the neural circuitry that governs energy expenditure in vivo...
  38. pmc Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR
    Yanqiao Zhang
    Department of Biological Chemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Genes Dev 18:157-69. 2004
    ..Our data suggest that PGC-1alpha plays an important physiological role in maintaining energy homeostasis during fasting by decreasing triglyceride production/secretion while it increases fatty acid beta-oxidation to meet energy needs...
  39. pmc Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart
    Ling Lai
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genes Dev 22:1948-61. 2008
    ..We conclude that PGC-1alpha and PGC-1beta share roles that collectively are necessary for the postnatal metabolic and functional maturation of heart and BAT...
  40. ncbi RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR
    Patrick Lau
    Institute for Molecular Bioscience, Division of Molecular Genetics and Development, School of Biomedical Sciences, University of Queensland, St Lucia, Queensland 4072, Australia
    J Biol Chem 279:36828-40. 2004
    ..In conclusion, we speculate that ROR agonists would increase fatty acid catabolism in muscle and suggest selective activators of ROR may have therapeutic utility in the treatment of obesity and atherosclerosis...
  41. pmc The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}
    Agnes Coste
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch, France
    Proc Natl Acad Sci U S A 105:17187-92. 2008
    ..Collectively, these data suggest that SRC-3 is a critical link in a cofactor network that uses PGC-1alpha as an effector to control mitochondrial function and energy homeostasis...
  42. ncbi Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expression
    T Kakuma
    Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Endocrinology 141:4576-82. 2000
    ..We conclude that leptin action is required for normal basal and cold-stimulated PGC-1 expression in BAT in rodents and that hyperleptinemia rapidly up-regulates its expression, at least in part, by direct action...
  43. pmc Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5
    Michael P Czubryt
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 100:1711-6. 2003
    ..These findings identify PGC-1 alpha as a key target of the MEF2/HDAC regulatory pathway and demonstrate this pathway's importance in maintenance of cardiac mitochondrial function...
  44. ncbi Overexpression of peroxisome proliferator-activated receptor gamma coactivator-1alpha down-regulates GLUT4 mRNA in skeletal muscles
    Shinji Miura
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Biol Chem 278:31385-90. 2003
    ..Thus, an increase of PGC-1alpha plays a role in increasing mitochondrial biogenesis and fatty acid oxidation but not in increasing GLUT4 mRNA in skeletal muscles...
  45. pmc Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
    Vamsi K Mootha
    The Eli and Edythe L Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139 1561, USA
    Proc Natl Acad Sci U S A 101:6570-5. 2004
    ....
  46. pmc Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development
    Jean Bernard Beaudry
    box 7529, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    Mol Cell Biol 26:6037-46. 2006
    ..Our observations on the regulation of g6pc by HNF-6 provide a model whereby synergism, interdependency, and threshold concentrations of LETFs and coactivators determine time-specific expression of genes during liver development...
  47. pmc Overexpression of peroxisome proliferator-activated receptor gamma co-activator-1alpha leads to muscle atrophy with depletion of ATP
    Shinji Miura
    Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Am J Pathol 169:1129-39. 2006
    ..Our results indicate that overexpression of PGC-1alpha in skeletal muscle increases not only mitochondrial biogenesis but also uncoupling of respiration, resulting in muscle atrophy...
  48. pmc Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
    Cheol Soo Choi
    Departments of Internal Medicine and Cellular and Molecular Physiology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 105:19926-31. 2008
    ..This, in turn, caused activation of PKC, decreased insulin signaling at the level of insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation, and skeletal muscle insulin resistance...
  49. pmc Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy
    Jeffrey J Brault
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:19460-71. 2010
    ..This capacity of PGC-1alpha and PGC-1beta to inhibit FoxO3 and NFkappaB actions and proteolysis helps explain how exercise prevents muscle atrophy...
  50. ncbi A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    P Puigserver
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 92:829-39. 1998
    ..These results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis...
  51. ncbi Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-gamma coactivator-1
    O Boss
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Biochem Biophys Res Commun 261:870-6. 1999
    ..This effect is probably indirect, as muscle does not seem to express beta(3)-AR. In addition, our data suggest that BRL 37344 and CGP 12177 act, in part, through an as yet unidentified receptor, possibly a beta(4)-AR...
  52. ncbi Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression
    H Esterbauer
    Department of Laboratory Medicine, Landeskliniken Salzburg, Salzburg, Austria
    Genomics 62:98-102. 1999
    ..1998, Cell 92, 829-839). We report here the characterization of the human PPARGC1 gene...
  53. pmc Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
    J J Lehman
    Department of Medicine, and Department of Pathology, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 106:847-56. 2000
    ..These results identify PGC-1 as a critical regulatory molecule in the control of cardiac mitochondrial number and function in response to energy demands...
  54. ncbi Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
    Pere Puigserver
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 423:550-5. 2003
    ..known as FKHR) and peroxisome proliferative activated receptor-gamma co-activator 1 (PGC-1alpha; also known as PPARGC1), a transcriptional co-activator; whether and how these factors collaborate has not been clear...
  55. pmc An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:7111-6. 2003
    ..Furthermore, these data suggest an autofeedback loop whereby the calcium-signaling pathway may result in a stable induction of PGC-1alpha, contributing to the relatively stable nature of muscle fiber-type determination...
  56. ncbi PGC-1alpha activates CYP7A1 and bile acid biosynthesis
    Dong Ju Shin
    Department of Molecular Biology and Biochemistry, University of California, Irvine California 92697 3900, USA
    J Biol Chem 278:50047-52. 2003
    ..Our studies provide further evidence of the fundamental role played by PGC-1alpha in oxidative metabolism and define PGC-1alpha as a link between diabetes and bile acid metabolism...
  57. ncbi Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner
    Laurie K Russell
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 94:525-33. 2004
    ....
  58. ncbi PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3
    Seung Hoi Koo
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nat Med 10:530-4. 2004
    ..These results indicate a link between nuclear hormone receptor and insulin signaling pathways, and suggest a potential role for TRB-3 inhibitors in the treatment of type 2 diabetes...
  59. ncbi Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 119:121-35. 2004
    ..These data illustrate a central role for PGC-1alpha in the control of energy metabolism but also reveal novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis...
  60. ncbi SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
    Shino Nemoto
    Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 280:16456-60. 2005
    ..These results provide a direct link between the sirtuins, a family of proteins linked to lifespan determination and PGC-1alpha, a coactivator that regulates cellular metabolism...
  61. ncbi Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    Joseph T Rodgers
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 434:113-8. 2005
    ..Thus, we have identified a molecular mechanism whereby SIRT1 functions in glucose homeostasis as a modulator of PGC-1alpha. These findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan...
  62. ncbi Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction
    Lindsay M Angus
    Department of Cellular and Molecular Medicine, and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5
    Am J Physiol Cell Physiol 289:C908-17. 2005
    ..Together, these studies indicate that the synaptic expression of utrophin is also driven by calcineurin-NFAT signaling and occurs in conjunction with signaling events that involve GABP and PGC-1alpha...
  63. pmc PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
    Brian N Finck
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:615-22. 2006
    ..This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure...
  64. ncbi Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation
    Marc Uldry
    Dana Farber Cancer Institute, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Cell Metab 3:333-41. 2006
    ....
  65. ncbi GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha
    Carles Lerin
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Metab 3:429-38. 2006
    ..GCN5 might be a pharmacological target to regulate the activity of PGC-1alpha, providing a potential treatment for metabolic disorders in which hepatic glucose output is dysregulated...
  66. ncbi Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway
    Brian N Finck
    Center for Cardiovascular Research and Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Metab 4:199-210. 2006
    ..These results identify lipin 1 as a selective physiological amplifier of the PGC-1alpha/PPARalpha-mediated control of hepatic lipid metabolism...
  67. ncbi Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    Julie St-Pierre
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 127:397-408. 2006
    ..These studies reveal that PGC-1alpha is a broad and powerful regulator of ROS metabolism, providing a potential target for the therapeutic manipulation of these important endogenous toxins...
  68. pmc Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
    ..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing...
  69. pmc Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha
    Zachary Gerhart-Hines
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    EMBO J 26:1913-23. 2007
    ..These results have implications for understanding selective nutrient adaptation and how it might impact lifespan or metabolic diseases such as obesity and diabetes...
  70. ncbi An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation
    Shinji Miura
    Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Endocrinology 148:3441-8. 2007
    ..These data indicate that up-regulation of PGC-1alpha expression in skeletal muscle by exercise is mediated, at least in part, by beta-ARs activation. Among ARs, beta2-AR may mediate an increase in PGC-1alpha by exercise...
  71. ncbi Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism
    Chang Liu
    Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Nature 447:477-81. 2007
    ..Here we show that PGC-1alpha (Ppargc1a), a transcriptional coactivator that regulates energy metabolism, is rhythmically expressed in the liver and ..
  72. pmc AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
    Sibylle Jäger
    Dana Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:12017-22. 2007
    ..These data indicate that AMPK phosphorylation of PGC-1alpha initiates many of the important gene regulatory functions of AMPK in skeletal muscle...
  73. ncbi A role for the transcriptional coactivator PGC-1alpha in muscle refueling
    Adam R Wende
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:36642-51. 2007
    ..These findings identify PGC-1alpha as a critical regulator of skeletal muscle fuel stores...
  74. ncbi Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH
    Emmanuel Compe
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, C U Strasbourg, France
    Nat Neurosci 10:1414-22. 2007
    ..The discovery of an unexpected stabilizing function for TFIIH deepens our understanding of the pathogenesis and neurological manifestations observed in TTD individuals...
  75. ncbi mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
    John T Cunningham
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 450:736-40. 2007
    ..These results have important implications for our understanding of how these pathways might be altered in metabolic diseases and cancer...
  76. doi HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha
    Zoltan Arany
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 451:1008-12. 2008
    ..PGC-1alpha may provide a novel therapeutic target for treating ischaemic diseases...
  77. doi Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to beta2-adrenergic receptor activation and exercise
    Shinji Miura
    National Institute of Health and Nutrition, Tokyo 162 8636, Japan
    Endocrinology 149:4527-33. 2008
    ..These data indicate that AR activation is a major mechanism of an increase in PGC-1alpha expression in skeletal muscles, and the increase in PGC-1alpha mRNAs was isoform specific...
  78. pmc PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle
    Ines Pagel-Langenickel
    Translational Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 283:22464-72. 2008
    ..Pioglitazone functions in part via the induction of PGC-1alpha. Moreover, PGC-1alpha is identified as a bidirectional regulatory link integrating insulin-signaling and mitochondrial homeostasis in skeletal muscle...
  79. pmc PRDM16 controls a brown fat/skeletal muscle switch
    Patrick Seale
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nature 454:961-7. 2008
    ..Taken together, these data indicate that PRDM16 specifies the brown fat lineage from a progenitor that expresses myoblast markers and is not involved in white adipogenesis...
  80. doi The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in muscle
    Peter J Adhihetty
    School of Kinesiology and Health Science, York Univ, Toronto, Ontario, M3J 1P3, Canada
    Am J Physiol Cell Physiol 297:C217-25. 2009
    ....
  81. pmc Impaired PGC-1alpha function in muscle in Huntington's disease
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Hum Mol Genet 18:3048-65. 2009
    ..Furthermore, muscle may provide a readily accessible tissue in which to monitor therapeutic interventions...
  82. pmc SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD
    Ramon Amat
    Departament de Bioquimica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona, Barcelona 08028, Spain
    J Biol Chem 284:21872-80. 2009
    ..Autoregulatory control of PGC-1alpha gene transcription seems to be a pivotal mechanism for conferring a transcription-activating response to SIRT1 in skeletal muscle...
  83. pmc Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes
    Daniel O Espinoza
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    FASEB J 24:1003-14. 2010
    ..Espinoza, D. O., Boros, L. G., Crunkhorn, S., Gami, H., Patti, M.-E. Dual Modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes...
  84. pmc Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging
    Tina Wenz
    Department of Neurology, University of Miami School of Medicine, Miami, FL33136, USA
    Proc Natl Acad Sci U S A 106:20405-10. 2009
    ....
  85. pmc PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle
    Tuoyu Geng
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Am J Physiol Cell Physiol 298:C572-9. 2010
    ..We conclude that PGC-1alpha is required for complete skeletal muscle adaptations induced by endurance exercise in mice...
  86. doi Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1
    Masato Iwabu
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Nature 464:1313-9. 2010
    ..Decreased levels of adiponectin and AdipoR1 in obesity may have causal roles in mitochondrial dysfunction and insulin resistance seen in diabetes...
  87. pmc Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis
    Katia Aquilano
    Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    J Biol Chem 285:21590-9. 2010
    ..Finally, this work adds new knowledge on the function of SIRT1 and PGC-1alpha and highlights the direct involvement of such proteins in regulation of mitochondrial biogenesis...
  88. pmc Nitric oxide and AMPK cooperatively regulate PGC-1 in skeletal muscle cells
    Vitor A Lira
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    J Physiol 588:3551-66. 2010
    ..Further, this study supports a proposed model of synergistic interaction between AMPK and NOS that is critical for maintenance of metabolic function in skeletal muscle cells...
  89. pmc Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1{alpha} via the N-terminal pathway
    Julie Trausch-Azar
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 285:40192-200. 2010
    ..In contrast, the cellular localization of NT-PCG-1α results in a longer-half-life and possible distinct temporal and potentially biological actions...
  90. pmc Peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} (PGC-1{alpha}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway
    Serge Summermatter
    Division of Pharmacology Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    J Biol Chem 285:32793-800. 2010
    ..Our findings suggest that PGC-1α coordinates lipogenesis, intramyocellular lipid accumulation, and substrate oxidation in exercised skeletal muscle in vivo...
  91. pmc PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types
    Kyle A Rasbach
    Department of Cell Biology, The Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:21866-71. 2010
    ..These data indicate that HIF2α acts downstream of PGC-1α as a key regulator of a muscle fiber-type program and the adaptive response to exercise...
  92. pmc Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity
    Christoph Zechner
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Metab 12:633-42. 2010
    ..Taken together, we conclude that PGC-1 coactivators are necessary for the oxidative and mitochondrial programs of skeletal muscle but are dispensable for fundamental fiber type determination and insulin sensitivity...
  93. pmc Fiber type conversion by PGC-1α activates lysosomal and autophagosomal biogenesis in both unaffected and Pompe skeletal muscle
    Shoichi Takikita
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 5:e15239. 2010
    ..These findings may have implications for therapy of lysosomal diseases and other disorders with altered autophagy...
  94. pmc Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis
    Adeel Safdar
    Department of Kinesiology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Biol Chem 286:10605-17. 2011
    ..These results suggest that PGC-1α may dynamically facilitate nuclear-mitochondrial DNA cross-talk to promote net mitochondrial biogenesis...
  95. pmc PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
    Joo Ho Shin
    Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 144:689-702. 2011
    ..The identification of PARIS provides a molecular mechanism for neurodegeneration due to parkin inactivation...
  96. pmc Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) is a metabolic regulator of intestinal epithelial cell fate
    Ilenia D'Errico
    Laboratory of Lipid Metabolism and Cancer, Department of Translational Pharmacology, Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro, Chieti, Italy
    Proc Natl Acad Sci U S A 108:6603-8. 2011
    Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) is a transcriptional coactivator able to up-regulate mitochondrial biogenesis, respiratory capacity, oxidative phosphorylation, and fatty acid β-oxidation with the ..
  97. pmc Toll-like receptor-mediated inflammatory signaling reprograms cardiac energy metabolism by repressing peroxisome proliferator-activated receptor γ coactivator-1 signaling
    Joel Schilling
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Circ Heart Fail 4:474-82. 2011
    ..Peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) α and β serve as critical physiological regulators of energy metabolic gene expression in heart...
  98. pmc A peroxisome proliferator-activated receptor gamma (PPARgamma)/PPARgamma coactivator 1beta autoregulatory loop in adipocyte mitochondrial function
    Tuo Deng
    Methodist Hospital Research Institute, Center for Diabetes Research, Weill Cornell Medical College, The Methodist Hospital, Houston, Texas 77030, USA
    J Biol Chem 286:30723-31. 2011
    ..We propose that PPARγ directly induces PGC-1β expression in adipocytes and that this effect regulates adipocyte mitochondrial activity...
  99. pmc Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise
    Andrew Philp
    Department of Neurobiology, Physiology, and Behavior, University of California, Davis, California 95616, USA
    J Biol Chem 286:30561-70. 2011
    ....
  100. doi Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle
    Ling Li
    Institute of Physiology, Justus Liebig University Giessen, Aulweg 129, 35392 Giessen, Germany
    Basic Res Cardiol 106:1221-34. 2011
    ..AMPK activation by IL-6 appears to be dispensable for the mitochondrial biogenic responses to chronic treadmill exercise...
  101. doi Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease
    Giuseppa Mudo
    Department of Experimental Biomedicine and Clinical Neuroscience, Division of Human Physiology, University of Palermo, Italy
    Cell Mol Life Sci 69:1153-65. 2012
    ..RSV and other compounds acting via SIRT1/PGC-1α may prove useful as neuroprotective agents in PD and possibly in other neurological disorders...

Research Grants9

  1. MECHANISM AND ROLE OF MICROSOMAL ETHANOL OXIDATION
    Charles Lieber; Fiscal Year: 2001
    ..Such information is aimed at elucidating key aspects of alcohol mediated pathology in a way which may eventually affect alcohol related medical complications, their prevention and treatment. ..
  2. DLPC Treatment of Alcoholic and Non-Alcoholic Fibrosis
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  3. ANTIVIRAL & ANTIFIBROTIC LIVER THERAPY OF HCV+ DRINKERS
    Charles Lieber; Fiscal Year: 2005
    ..Funds are requested for special laboratory tests, study nurses, travel to meetings, patient monitoring expenses and a core office. ..
  4. Liver Fibrosis, Inflammation & Oxidative Stress Markers
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  5. Feasibility of Rehabilitation Robots and fMRI in Stroke
    A Tzika; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  6. Antiviral/Antifibrotic Liver Therapy of Hepatitis C positive Alcohol Drinkers
    Charles Lieber; Fiscal Year: 2007
    ..Accordingly, support is requested for the completion of this novel approach for the treatment of HCV+ patients who become abstinent or who continue to consume alcohol moderately. [unreadable] [unreadable]..
  7. Synergistic Nutraceutical Effects of DLPC and SAMe
    Charles Lieber; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  8. High throughput screening for modulators of the transcriptional coactivator PGC-1
    Zoltan Arany; Fiscal Year: 2007
    ..unreadable]..