Prdm16

Summary

Gene Symbol: Prdm16
Description: PR domain containing 16
Alias: 5730557K01Rik, csp1, mel1, PR domain zinc finger protein 16, MDS1/EVI1-like gene 1, PR domain-containing protein 16, line 27, transcription factor MEL1
Species: mouse
Products:     Prdm16

Top Publications

  1. Kinameri E, Inoue T, Aruga J, Imayoshi I, Kageyama R, Shimogori T, et al. Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. PLoS ONE. 2008;3:e3859 pubmed publisher
    ..In Hes null telencephalon neural differentiation is enhanced, Prdm8 expression is upregulated, and Prdm16 expression is downregulated; conversely in utero electroporation of Hes1 into the developing telencephalon ..
  2. Seale P, Kajimura S, Yang W, Chin S, Rohas L, Uldry M, et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 2007;6:38-54 pubmed
    ..We show here that the zinc-finger protein PRDM16 is highly enriched in brown fat cells compared to white fat cells...
  3. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008;454:961-7 pubmed publisher
    ..We also demonstrate that the transcriptional regulator PRDM16 (PRD1-BF1-RIZ1 homologous domain containing 16) controls a bidirectional cell fate switch between skeletal ..
  4. Aguilo F, Avagyan S, Labar A, Sevilla A, Lee D, Kumar P, et al. Prdm16 is a physiologic regulator of hematopoietic stem cells. Blood. 2011;117:5057-66 pubmed publisher
    ..b>PRDM16 is involved in human leukemic translocations and is expressed highly in some karyotypically normal acute ..
  5. Chuikov S, Levi B, Smith M, Morrison S. Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress. Nat Cell Biol. 2010;12:999-1006 pubmed publisher
    ..b>Prdm16 is a transcription factor that regulates leukaemogenesis, palatogenesis and brown-fat development, but which was ..
  6. Arndt A, Schafer S, Drenckhahn J, Sabeh M, Plovie E, Caliebe A, et al. Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy. Am J Hum Genet. 2013;93:67-77 pubmed publisher
    ..associated with 1p36del syndrome that included only the terminal 14 exons of the transcription factor PRDM16 (PR domain containing 16), a gene that had previously been shown to direct brown fat determination and ..
  7. Pinheiro I, Margueron R, Shukeir N, Eisold M, Fritzsch C, Richter F, et al. Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell. 2012;150:948-60 pubmed publisher
    ..We developed a biochemical assay and used in vivo analyses in mouse embryonic fibroblasts to identify Prdm3 and Prdm16 as redundant H3K9me1-specific KMTs that direct cytoplasmic H3K9me1 methylation...
  8. Shing D, Trubia M, Marchesi F, Radaelli E, Belloni E, Tapinassi C, et al. Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice. J Clin Invest. 2007;117:3696-707 pubmed
    ..We report here aberrant expression of PR domain containing 16 (PRDM16) in AML cells with either translocations of 1p36 or normal karyotype...
  9. Kajimura S, Seale P, Tomaru T, Erdjument Bromage H, Cooper M, Ruas J, et al. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008;22:1397-409 pubmed publisher
    ..b>PRDM16 is a zinc-finger protein that controls brown fat determination by stimulating brown fat-selective gene expression, ..
  10. Deneault E, Cellot S, Faubert A, Laverdure J, Fréchette M, Chagraoui J, et al. A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell. 2009;137:369-79 pubmed publisher
    ..The utilization of this screening method together with the creation of a database enriched for potential determinants of hematopoietic stem cell self-renewal will serve as a resource to uncover regulatory networks in these cells. ..

Detail Information

Publications62

  1. Kinameri E, Inoue T, Aruga J, Imayoshi I, Kageyama R, Shimogori T, et al. Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. PLoS ONE. 2008;3:e3859 pubmed publisher
    ..In Hes null telencephalon neural differentiation is enhanced, Prdm8 expression is upregulated, and Prdm16 expression is downregulated; conversely in utero electroporation of Hes1 into the developing telencephalon ..
  2. Seale P, Kajimura S, Yang W, Chin S, Rohas L, Uldry M, et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 2007;6:38-54 pubmed
    ..We show here that the zinc-finger protein PRDM16 is highly enriched in brown fat cells compared to white fat cells...
  3. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008;454:961-7 pubmed publisher
    ..We also demonstrate that the transcriptional regulator PRDM16 (PRD1-BF1-RIZ1 homologous domain containing 16) controls a bidirectional cell fate switch between skeletal ..
  4. Aguilo F, Avagyan S, Labar A, Sevilla A, Lee D, Kumar P, et al. Prdm16 is a physiologic regulator of hematopoietic stem cells. Blood. 2011;117:5057-66 pubmed publisher
    ..b>PRDM16 is involved in human leukemic translocations and is expressed highly in some karyotypically normal acute ..
  5. Chuikov S, Levi B, Smith M, Morrison S. Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress. Nat Cell Biol. 2010;12:999-1006 pubmed publisher
    ..b>Prdm16 is a transcription factor that regulates leukaemogenesis, palatogenesis and brown-fat development, but which was ..
  6. Arndt A, Schafer S, Drenckhahn J, Sabeh M, Plovie E, Caliebe A, et al. Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy. Am J Hum Genet. 2013;93:67-77 pubmed publisher
    ..associated with 1p36del syndrome that included only the terminal 14 exons of the transcription factor PRDM16 (PR domain containing 16), a gene that had previously been shown to direct brown fat determination and ..
  7. Pinheiro I, Margueron R, Shukeir N, Eisold M, Fritzsch C, Richter F, et al. Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell. 2012;150:948-60 pubmed publisher
    ..We developed a biochemical assay and used in vivo analyses in mouse embryonic fibroblasts to identify Prdm3 and Prdm16 as redundant H3K9me1-specific KMTs that direct cytoplasmic H3K9me1 methylation...
  8. Shing D, Trubia M, Marchesi F, Radaelli E, Belloni E, Tapinassi C, et al. Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice. J Clin Invest. 2007;117:3696-707 pubmed
    ..We report here aberrant expression of PR domain containing 16 (PRDM16) in AML cells with either translocations of 1p36 or normal karyotype...
  9. Kajimura S, Seale P, Tomaru T, Erdjument Bromage H, Cooper M, Ruas J, et al. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008;22:1397-409 pubmed publisher
    ..b>PRDM16 is a zinc-finger protein that controls brown fat determination by stimulating brown fat-selective gene expression, ..
  10. Deneault E, Cellot S, Faubert A, Laverdure J, Fréchette M, Chagraoui J, et al. A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell. 2009;137:369-79 pubmed publisher
    ..The utilization of this screening method together with the creation of a database enriched for potential determinants of hematopoietic stem cell self-renewal will serve as a resource to uncover regulatory networks in these cells. ..
  11. Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni J, Gygi S, et al. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 2009;460:1154-8 pubmed publisher
    ..b>PRDM16 (PR domain containing 16) is a 140 kDa zinc finger protein that robustly induces brown fat determination and ..
  12. Herron B, Lu W, Rao C, Liu S, Peters H, Bronson R, et al. Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat Genet. 2002;30:185-9 pubmed
    ..Using a hierarchical approach, it is possible to maximize the efficiency of this analysis so that it can be carried out easily with modest infrastructure and resources. ..
  13. Ohno H, Shinoda K, Spiegelman B, Kajimura S. PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 2012;15:395-404 pubmed publisher
    ..These effects require expression of PRDM16, a factor that controls the development of classical brown fat...
  14. Bjork B, Turbe Doan A, Prysak M, Herron B, Beier D. Prdm16 is required for normal palatogenesis in mice. Hum Mol Genet. 2010;19:774-89 pubmed publisher
    ..N-ethyl-N-nitrosourea-induced mouse model of non-syndromic cleft palate (NSCP) that is caused by an intronic Prdm16 splicing mutation...
  15. Nishikata I, Sasaki H, Iga M, Tateno Y, Imayoshi S, Asou N, et al. A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation. Blood. 2003;102:3323-32 pubmed
    We have identified a novel gene MEL1 (MDS1/EVI1-like gene 1) encoding a zinc finger protein near the breakpoint of t(1; 3)(p36;q21)-positive human acute myeloid leukemia (AML) cells...
  16. Du Y, Jenkins N, Copeland N. Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. Blood. 2005;106:3932-9 pubmed
    ..More than half of the lines have MSCV insertions at Evi1 or Prdm16. These loci encode transcription factor homologs and are validated human myeloid leukemia genes...
  17. Hall J, Ribich S, Christoffolete M, Simovic G, Correa Medina M, Patti M, et al. Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology. 2010;151:4573-82 pubmed publisher
    ..This discovery highlights the importance of deiodinase-controlled thyroid hormone signaling in BAT development, where it has important metabolic repercussions for energy homeostasis in adulthood. ..
  18. Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, et al. Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression. PLoS Genet. 2017;13:e1006950 pubmed publisher
    ..C/EBP-β) protein, which cooperates with dominant transcriptional co-regulator PR domain containing 16 (PRDM16) to determine brown/beige adipocyte lineage, is essential for the enhanced adipocyte browning caused by the loss ..
  19. Groman Lupa S, Adewumi J, Park K, Brzezinski Iv J. The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina. Invest Ophthalmol Vis Sci. 2017;58:5421-5433 pubmed publisher
    ..We tested whether the Prdm16 transcription factor is expressed by RGCs as a class or within particular ganglion cell subtypes...
  20. Choi J, Kim K, Koh E, Lee B. Gelidium elegans Regulates the AMPK-PRDM16-UCP-1 Pathway and Has a Synergistic Effect with Orlistat on Obesity-Associated Features in Mice Fed a High-Fat Diet. Nutrients. 2017;9: pubmed publisher
    ..gain through modulation of the adenosine monophosphate-activated protein kinase (AMPK)-PR domain-containing16 (PRDM16)-uncoupling protein-1 (UCP-1) pathway in a mice model...
  21. Avagyan S, Aguilo F, Kamezaki K, Snoeck H. Quantitative trait mapping reveals a regulatory axis involving peroxisome proliferator-activated receptors, PRDM16, transforming growth factor-β2 and FLT3 in hematopoiesis. Blood. 2011;118:6078-86 pubmed publisher
    ..A coding polymorphism in Prdm16 (PR-domain-containing 16) underlies Tb2r1 and differentially regulates transcriptional activity of peroxisome ..
  22. Li X, Wang J, Jiang Z, Guo F, Soloway P, Zhao R. Role of PRDM16 and its PR domain in the epigenetic regulation of myogenic and adipogenic genes during transdifferentiation of C2C12 cells. Gene. 2015;570:191-8 pubmed publisher
    The positive regulatory domain containing 16 (PRDM16) is commonly regarded as a "switch" controlling the transdifferentiation of myoblasts to brown adipocytes...
  23. Singh R, Braga M, Reddy S, Lee S, Parveen M, Grijalva V, et al. Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues. Endocrinology. 2017;158:1217-1230 pubmed publisher
    ..of Fst-Tg mice had increased expression of brown adipose-associated markers including uncoupling protein 1 (UCP1), PRDM16, PGC-1α, and Glut4...
  24. Park J, Kang H, Kang S, Lee J, Hur J, Ge K, et al. A multifunctional protein, EWS, is essential for early brown fat lineage determination. Dev Cell. 2013;26:393-404 pubmed publisher
    ..Remarkably, Ews null BATs and brown preadipocytes ectopically express myogenic genes. These results demonstrate that EWS is essential for early brown fat lineage determination. ..
  25. Trajkovski M, Ahmed K, Esau C, Stoffel M. MyomiR-133 regulates brown fat differentiation through Prdm16. Nat Cell Biol. 2012;14:1330-5 pubmed
    ..A key regulator of BAT is the gene encoding PR domain containing 16 (Prdm16), whose expression can drive differentiation of myogenic and white fat precursors to brown adipocytes...
  26. Inoue M, Iwai R, Tabata H, Konno D, Komabayashi Suzuki M, Watanabe C, et al. Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex. Development. 2017;144:385-399 pubmed publisher
    ..The Prdm16 gene was identified as a candidate modulator of mtROS using microarray analysis, and was specifically expressed by ..
  27. Harms M, Lim H, Ho Y, Shapira S, Ishibashi J, Rajakumari S, et al. PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program. Genes Dev. 2015;29:298-307 pubmed publisher
    PR (PRD1-BF1-RIZ1 homologous) domain-containing 16 (PRDM16) drives a brown fat differentiation program, but the mechanisms by which PRDM16 activates brown fat-selective genes have been unclear...
  28. Park Y, Wang L, Giampietro A, Lai B, Lee J, Ge K. Distinct Roles of Transcription Factors KLF4, Krox20, and Peroxisome Proliferator-Activated Receptor γ in Adipogenesis. Mol Cell Biol. 2017;37: pubmed publisher
    ..These results challenge the existing model on transcriptional regulation in the early phase of adipogenesis and highlight the need of studying adipogenesis in vivo. ..
  29. Zhou H, Black S, Benson T, Weintraub N, Chen W. Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is Not Required for Brown Adipogenesis but Regulates Brown Adipose Tissue Development and Function. Mol Cell Biol. 2016;36:2027-38 pubmed publisher
    ....
  30. Van De Pette M, Tunster S, McNamara G, Shelkovnikova T, Millership S, Benson L, et al. Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome. PLoS Genet. 2016;12:e1005916 pubmed publisher
    ..Cdkn1c is required for post-transcriptional accumulation of the brown fat determinant PR domain containing 16 (PRDM16) and that CDKN1C and PRDM16 co-localise to the nucleus of rare label-retaining cell within iBAT...
  31. Yin H, Pasut A, Soleimani V, Bentzinger C, Antoun G, Thorn S, et al. MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metab. 2013;17:210-24 pubmed publisher
    ..that microRNA-133 regulates the choice between myogenic and brown adipose determination by targeting the 3'UTR of Prdm16. Antagonism of microRNA-133 during muscle regeneration increases uncoupled respiration, glucose uptake, and ..
  32. Sun C, Berry W, Olson L. PDGFRα controls the balance of stromal and adipogenic cells during adipose tissue organogenesis. Development. 2017;144:83-94 pubmed publisher
    ..Our data highlight the importance of balancing stromal versus adipogenic cell expansion during white adipose tissue development, with PDGFRα activity coordinating this crucial process in the embryo. ..
  33. Modlich U, Schambach A, Brugman M, Wicke D, Knoess S, Li Z, et al. Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16. Leukemia. 2008;22:1519-28 pubmed publisher
    ..of six distinct clones harboring gamma-retroviral long terminal repeat (LTR) or SIN vector insertions in Evi1 or Prdm16, two functionally related genes...
  34. Gyurján I, Sonderegger B, Naef F, Duboule D. Analysis of the dynamics of limb transcriptomes during mouse development. BMC Dev Biol. 2011;11:47 pubmed publisher
    ..These datasets provide a valuable resource, either for research projects involving gene expression and regulation in developing mouse limbs, or as examples of tissue-specific, genome-wide transcriptional activities. ..
  35. Nosavanh L, Yu D, Jaehnig E, Tong Q, Shen L, Chen M. Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development. Proc Natl Acad Sci U S A. 2015;112:5069-74 pubmed publisher
    ..Taken together, our studies uncover a previously unidentified role for Hh as an inhibitor of BAT development. ..
  36. Chi J, Wu Z, Choi C, Nguyen L, Tegegne S, Ackerman S, et al. Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density. Cell Metab. 2018;27:226-236.e3 pubmed publisher
    ..We present evidence that the density of sympathetic projections is dependent on PRDM16 in adipocytes, providing another potential mechanism underlying the metabolic benefits mediated by PRDM16...
  37. Horn K, Warner D, Pisano M, Greene R. PRDM16 expression in the developing mouse embryo. Acta Histochem. 2011;113:150-5 pubmed publisher
    b>PRDM16 is a member of the PR domain-containing protein family and is associated with various disease states including myelodysplastic syndrome and adult T-cell leukemia, as well as developmental abnormalities such as cleft palate...
  38. Benitez C, Qu K, Sugiyama T, Pauerstein P, Liu Y, Tsai J, et al. An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development. PLoS Genet. 2014;10:e1004645 pubmed publisher
    ..of a subset of candidate regulators with corresponding mutant mice revealed that the transcription factors Etv1, Prdm16, Runx1t1 and Bcl11a are essential for pancreas development...
  39. Warner D, Mukhopadhyay P, Webb C, Greene R, Pisano M. Chromatin immunoprecipitation-promoter microarray identification of genes regulated by PRDM16 in murine embryonic palate mesenchymal cells. Exp Biol Med (Maywood). 2012;237:387-94 pubmed publisher
    The transcription factor PRDM16 regulates differentiation of brown adipocyte tissue in mice...
  40. Warner D, Wells J, Greene R, Pisano M. Gene expression changes in the secondary palate and mandible of Prdm16(-/-) mice. Cell Tissue Res. 2013;351:445-52 pubmed publisher
    Loss of Prdm16 expression in the mouse leads to a complete cleft of the secondary palate...
  41. Deneault E, Wilhelm B, Bergeron A, Barabé F, Sauvageau G. Identification of non-cell-autonomous networks from engineered feeder cells that enhance murine hematopoietic stem cell activity. Exp Hematol. 2013;41:470-478.e4 pubmed publisher
    ..Five of these factors, namely FOS, SPI1, KLF10, TFEC, and PRDM16, show robust transcriptional cross-regulation and are often associated with osteoclastogenesis...
  42. Fruhbeck G, Sesma P, Burrell M. PRDM16: the interconvertible adipo-myocyte switch. Trends Cell Biol. 2009;19:141-6 pubmed publisher
    ..recent study shows that overexpression of the transcriptional regulator positive regulatory domain containing 16 (PRDM16) determines the development of brown adipocytes from a progenitor that expresses myoblast markers...
  43. Yang Q, Liang X, Sun X, Zhang L, Fu X, Rogers C, et al. AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis. Cell Metab. 2016;24:542-554 pubmed publisher
    ..protein kinase (AMPK) may play a direct role in the process and found that AMPKα1 (PRKAA1) ablation reduced Prdm16 expression and impaired BAT development...
  44. Lin J, Lu Y, Liu Y, Lin Y. RBM4a-regulated splicing cascade modulates the differentiation and metabolic activities of brown adipocytes. Sci Rep. 2016;6:20665 pubmed publisher
    ..These results constitute a mechanistic understanding of the RBM4a-modulated splicing cascade during the brown adipogenesis. ..
  45. Kissig M, Ishibashi J, Harms M, Lim H, Stine R, Won K, et al. PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing. EMBO J. 2017;36:1528-1542 pubmed publisher
    ..b>PRDM16 is a transcription factor that activates brown fat-specific genes while repressing white fat and muscle-specific ..
  46. Hondares E, Rosell M, Diaz Delfin J, Olmos Y, Monsalve M, Iglesias R, et al. Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16. J Biol Chem. 2011;286:43112-22 pubmed publisher
    ..Moreover, PPARα- and cAMP-mediated pathways interacted to control PGC-1α transcription. PRDM16 (PRD1-BF1-RIZ1 homologous domain-containing 16) promoted PPARα induction of PGC-1α gene transcription, ..
  47. Huang L, Pan D, Chen Q, Zhu L, Ou J, Wabitsch M, et al. Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation. Nat Commun. 2017;8:68 pubmed publisher
    ..Hlx interacts with and is co-activated by Prdm16 to control BAT-selective gene expression and mitochondrial biogenesis...
  48. Luchsinger L, de Almeida M, Corrigan D, Mumau M, Snoeck H. Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential. Nature. 2016;529:528-31 pubmed publisher
    ..Here we show in mice that the short isoform of a critical regulator of HSCs, Prdm16 (refs 4, 5), induces mitofusin 2 (Mfn2), a protein involved in mitochondrial fusion and in tethering of ..
  49. Liu W, Kuang S. miR-133 links to energy balance through targeting Prdm16. J Mol Cell Biol. 2013;5:432-4 pubmed publisher
  50. Jiang Y, Berry D, Graff J. Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation. elife. 2017;6: pubmed publisher
    ..Necessity tests, using mature adipocyte-specific Prdm16 deletion strategies, demonstrated that adipocytes are required and are predominant source to generate Adrb3<..
  51. Iida S, Chen W, Nakadai T, Ohkuma Y, Roeder R. PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1. Genes Dev. 2015;29:308-21 pubmed publisher
    PR domain-containing 16 (PRDM16) induces expression of brown fat-specific genes in brown and beige adipocytes, although the underlying transcription-related mechanisms remain largely unknown...
  52. Strassman A, Schnütgen F, Dai Q, Jones J, Gomez A, Pitstick L, et al. Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping. Dis Model Mech. 2017;10:909-922 pubmed publisher
    ..for generating conditional mutations and validated this strategy in mice carrying a multipurpose allele of the Prdm16 transcription factor gene...
  53. Borensztein M, Viengchareun S, Montarras D, Journot L, Binart N, Lombes M, et al. Double Myod and Igf2 inactivation promotes brown adipose tissue development by increasing Prdm16 expression. FASEB J. 2012;26:4584-91 pubmed publisher
    ..More strikingly, expression of the master key gene Prdm16 involved in the switch between myogenic and brown adipogenic lineages was drastically enhanced...
  54. Kir S, White J, Kleiner S, Kazak L, Cohen P, Baracos V, et al. Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature. 2014;513:100-4 pubmed publisher
    ..Thus, neutralization of PTHrP might hold promise for ameliorating cancer cachexia and improving patient survival. ..
  55. Calo E, Quintero Estades J, Danielian P, Nedelcu S, Berman S, Lees J. Rb regulates fate choice and lineage commitment in vivo. Nature. 2010;466:1110-4 pubmed publisher
    ..Here we use mouse models to address this hypothesis in mesenchymal tissue development and tumorigenesis. Our data show that Rb status plays a key role in establishing fate choice between bone and brown adipose tissue in vivo. ..
  56. Warner D, Horn K, Mudd L, Webb C, Greene R, Pisano M. PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue. Biochim Biophys Acta. 2007;1773:814-20 pubmed
    ..The PR-domain containing protein, PRDM16/MEL1 was identified as a novel Smad binding protein...
  57. Park Y, Ge K. Glucocorticoid Receptor Accelerates, but Is Dispensable for, Adipogenesis. Mol Cell Biol. 2017;37: pubmed publisher
    ..These results clarify the role of GR in adipogenesis in vivo and demonstrate that DEX-mediated activation of GR accelerates, but is dispensable for, adipogenesis. ..
  58. Jin Q, Wang C, Kuang X, Feng X, Sartorelli V, Ying H, et al. Gcn5 and PCAF regulate PPARγ and Prdm16 expression to facilitate brown adipogenesis. Mol Cell Biol. 2014;34:3746-53 pubmed publisher
    ..However, neither PPARγ ectopic expression nor prolonged IBMX treatment rescued defects in Prdm16 expression in DKO cells, indicating that Gcn5/PCAF are essential for normal Prdm16 expression...
  59. Ohno H, Shinoda K, Ohyama K, Sharp L, Kajimura S. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature. 2013;504:163-7 pubmed publisher
    ..indicates that brown adipocytes arise from Myf5(+) dermotomal precursors through the action of PR domain containing protein 16 (PRDM16) transcriptional complex...
  60. Yu H, Neale G, Zhang H, Lee H, Ma Z, Zhou S, et al. Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo. Blood. 2014;124:1737-47 pubmed publisher
    ..b>Prdm16, a transcription factor associated with human acute myeloid leukemia, was markedly repressed by HOXB4 but ..
  61. Seale P, Conroe H, Estall J, Kajimura S, Frontini A, Ishibashi J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest. 2011;121:96-105 pubmed publisher
    ..Here, we found that Prdm16, a brown adipose determination factor, is selectively expressed in subcutaneous white adipocytes relative to other ..
  62. Cohen P, Levy J, Zhang Y, Frontini A, Kolodin D, Svensson K, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014;156:304-16 pubmed publisher
    ..Here, we show that adipocyte-specific deletion of the coregulatory protein PRDM16 caused minimal effects on classical brown fat but markedly inhibited beige adipocyte function in subcutaneous fat ..