Prkcb

Summary

Gene Symbol: Prkcb
Description: protein kinase C, beta
Alias: PKC-B, PKC-Beta, Pkcb, Prkcb1, Prkcb2, protein kinase C beta type, protein kinase C beta-II, protein kinase C, beta 1
Species: mouse

Top Publications

  1. ncbi Interleukin-3 or erythropoietin induced nuclear localization of protein kinase C beta isoforms in hematopoietic target cells
    M Mason-Garcia
    Department of Anatomy, Tulane University School of Medicine, New Orleans, Louisiana, USA
    Cell Prolif 28:145-55. 1995
  2. ncbi PKC-beta is not necessary for cardiac hypertrophy
    B B Roman
    Section of Cardiology, Department of Medicine, University of Illinois at Chicago, Illinois 60612, USA
    Am J Physiol Heart Circ Physiol 280:H2264-70. 2001
  3. pmc Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior
    Klara R Birikh
    Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, Israel
    Proc Natl Acad Sci U S A 100:283-8. 2003
  4. ncbi Selective role of PKCbeta enzymatic function in regulating cell survival mediated by B cell antigen receptor cross-linking
    Chandrasekar Venkataraman
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Immunol Lett 105:83-9. 2006
  5. ncbi Mice lacking protein kinase C beta present modest increases in systolic blood pressure and NH4Cl-induced metabolic acidosis
    Li Jun Yao
    Institute of Pharmacology and Toxicology, University of Tubingen, Tubingen, Germany
    Kidney Blood Press Res 29:36-42. 2006
  6. ncbi Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc
    Paolo Pinton
    Department of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation ICSI, University of Ferrara, Ferrera, Italy
    Science 315:659-63. 2007
  7. pmc Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation
    N Muge Kuyumcu-Martinez
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 28:68-78. 2007
  8. ncbi Reassignment of the H-ras-1 gene to the Hbb-terminus region of mouse chromosome 7
    A B Bianchi
    University of Texas, M D Anderson Cancer Center, Smithville 78957
    Mamm Genome 4:220-2. 1993
  9. doi Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products
    Jong Sun Chang
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA
    Circ Res 102:905-13. 2008
  10. ncbi Immunodeficiency in protein kinase cbeta-deficient mice
    M Leitges
    Max Delbruck Laboratorium in der Max Planck Gesellschaft, Carl von Linne Weg 10, D 50829 Köln, Germany
    Science 273:788-91. 1996

Scientific Experts

  • Johan W M Heemskerk
  • Joseph A Brzezinski
  • J Menne
  • Giuseppe M Campo
  • SHI-FANG F YAN
  • Maria M Viveiros
  • Shaoyou Chu
  • W Glen Pyle
  • R Tian
  • Kaoru Saijo
  • George King
  • YUNXIA W LUNDBERG
  • B B Roman
  • Matthias Meier
  • Chandrasekar Venkataraman
  • Michael Leitges
  • Wei Huang
  • Yu Shan Zou
  • Diasynou Fioravante
  • Linghua Kong
  • Jong Sun Chang
  • Madhu Mehta
  • Yunxiang Chu
  • Ann Marie Schmidt
  • Wade G Regehr
  • Kamal D Mehta
  • Chun Huang
  • Rishipal R Bansode
  • Paolo Pinton
  • Nicole R Murray
  • Alan P Fields
  • Yuko Kawakami
  • David J Rawlings
  • Yuzuru Ohshiro
  • Z Chen
  • David Oleksyn
  • C E Teh
  • Gloria Lutzny
  • Mathieu Ferron
  • Xiaoquan Rao
  • KAMAL MEHTA
  • Nathalie Avazeri
  • Akihiko Ikeda
  • Carrie N Arnold
  • Jiro Kitaura
  • Hyung Min Jeong
  • Dongman Chao
  • Hilde Abrahamsen
  • Michael H Myoga
  • Sang Ki Lee
  • Alexander Egle
  • Toshiaki Kawakami
  • Kiyoshi Suzuma
  • Ki Ho Park
  • Maria Almeida
  • Dieter Paul Hoyer
  • Takashi Yamamoto
  • Pan Yue Deng
  • Anita M Hennige
  • Manuela Piazzi
  • Young Ae Kim
  • Nicole Joller
  • Carolina Pinzon-Guzman
  • Alexandra C Newton
  • Debra L Rigor
  • Kerstin Fehrenbach
  • E Kleiman
  • Claudia Holler
  • Valeria C Grossoni
  • Qinghang Liu
  • Mathilde A Poussin
  • Evis Harja
  • Jian Xin Liu
  • Joyce Shi Ying Lam
  • Dan Chen
  • Anne Denys
  • N Muge Kuyumcu-Martinez
  • Shigeru Sato
  • Benchang Guo
  • Keiko Naruse
  • Tomohiro Asai
  • Yiran Zhou
  • Hao Wang
  • Wan Young Kim
  • Li Jun Yao
  • Clifford A Lowell
  • Zhimei Du
  • Seigo Itoh
  • Allen C Clermont
  • Martin Andrassy

Detail Information

Publications115 found, 100 shown here

  1. ncbi Interleukin-3 or erythropoietin induced nuclear localization of protein kinase C beta isoforms in hematopoietic target cells
    M Mason-Garcia
    Department of Anatomy, Tulane University School of Medicine, New Orleans, Louisiana, USA
    Cell Prolif 28:145-55. 1995
    ....
  2. ncbi PKC-beta is not necessary for cardiac hypertrophy
    B B Roman
    Section of Cardiology, Department of Medicine, University of Illinois at Chicago, Illinois 60612, USA
    Am J Physiol Heart Circ Physiol 280:H2264-70. 2001
    ..These results demonstrate that PKC-beta expression is not necessary for the development of cardiac hypertrophy nor does its absence attenuate the hypertrophic response...
  3. pmc Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior
    Klara R Birikh
    Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, Israel
    Proc Natl Acad Sci U S A 100:283-8. 2003
    ..These findings are consistent with the hypothesis that stress-associated changes in cholinergic gene expression regulate neuronal PKCbetaII functioning, promoting fear-induced conflict behavior after stress...
  4. ncbi Selective role of PKCbeta enzymatic function in regulating cell survival mediated by B cell antigen receptor cross-linking
    Chandrasekar Venkataraman
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Immunol Lett 105:83-9. 2006
    ..These results support the important and selective role of the PKCbeta enzymatic function in controlling Ca2+ release during BCR signaling leading to B lymphocyte survival and growth...
  5. ncbi Mice lacking protein kinase C beta present modest increases in systolic blood pressure and NH4Cl-induced metabolic acidosis
    Li Jun Yao
    Institute of Pharmacology and Toxicology, University of Tubingen, Tubingen, Germany
    Kidney Blood Press Res 29:36-42. 2006
    ....
  6. ncbi Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc
    Paolo Pinton
    Department of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation ICSI, University of Ferrara, Ferrera, Italy
    Science 315:659-63. 2007
    ..These data identify a signaling route that activates an apoptotic inducer shortening the life span and could be a potential target of pharmacological approaches to inhibit aging...
  7. pmc Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation
    N Muge Kuyumcu-Martinez
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 28:68-78. 2007
    ..These results indicate that inappropriate activation of the PKC pathway contributes to the pathogenic effects of a noncoding RNA...
  8. ncbi Reassignment of the H-ras-1 gene to the Hbb-terminus region of mouse chromosome 7
    A B Bianchi
    University of Texas, M D Anderson Cancer Center, Smithville 78957
    Mamm Genome 4:220-2. 1993
  9. doi Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products
    Jong Sun Chang
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA
    Circ Res 102:905-13. 2008
    ..These findings identify RAGE as a master regulator of tissue stress elicited by hypoxia and highlight this receptor as a central therapeutic target to suppress the tissue injury-provoking effects of oxygen deprivation...
  10. ncbi Immunodeficiency in protein kinase cbeta-deficient mice
    M Leitges
    Max Delbruck Laboratorium in der Max Planck Gesellschaft, Carl von Linne Weg 10, D 50829 Köln, Germany
    Science 273:788-91. 1996
    ..Thus PKC-betaI and PKC-betaII play an important role in B cell activation and may be functionally linked to Bruton's tyrosine kinase in antigen receptor-mediated signal transduction...
  11. pmc The molecular mechanism of B cell activation by toll-like receptor protein RP-105
    V W Chan
    Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA
    J Exp Med 188:93-101. 1998
    ..We also find that negative regulation of RP-105-mediated activation of MAP kinases by membrane immunoglobulin may account for the phenomenon of antigen receptor-mediated arrest of RP-105-mediated B cell proliferation...
  12. ncbi Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cbeta
    H Nechushtan
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Blood 95:1752-7. 2000
    ..However, no significant changes were observed in the proliferative response of the mast cells to interleukin 3 (IL-3) or in their apoptotic rate after IL-3 depletion. (Blood. 2000;95:1752-1757)..
  13. pmc Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha
    Kaoru Saijo
    Laboratory of Lymphocyte Signaling, Rockefeller University, New York, NY 10021, USA
    J Exp Med 195:1647-52. 2002
    ....
  14. ncbi PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
    Thomas T Su
    The Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Nat Immunol 3:780-6. 2002
    ..Together, these data define an essential role for PKC-beta in BCR survival signaling and highlight PKC-beta as a key therapeutic target for B-lineage malignancies...
  15. ncbi Participation of protein kinase C beta in osteoclast differentiation and function
    S W Lee
    National Research Laboratory for Bone Metabolism, Chosun University, Gwangju 501 759, South Korea
    Bone 32:217-27. 2003
    ..Our findings indicate that PKC-beta has a role in regulation of osteoclast formation and function potentially by participating in the ERK signaling pathway of M-CSF and RANKL...
  16. ncbi Protein kinase C beta is dispensable for TCR-signaling
    Nikolaus Thuille
    Department for Medical Biology and Human Genetics, Innsbruck Medical University, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    Mol Immunol 41:385-90. 2004
    ..Thus, PKCbeta-deficient T cells had similar physiological thresholds for activation in vitro. These findings suggest that PKCbeta plays a redundant role in TCR-induced regulation of IL-2 cytokine production and T cell proliferation...
  17. ncbi Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion
    Yuko Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 279:47720-5. 2004
    ..Therefore, PKCbetaII appears to work as a cell type- and stimulus-specific PDK2...
  18. ncbi Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance
    Keiko Naruse
    Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes 55:691-8. 2006
    ....
  19. ncbi Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice
    Yuzuru Ohshiro
    Research Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 55:3112-20. 2006
    ..Lack of PKC-beta can protect against diabetes-induced renal dysfunction, fibrosis, and increased expressions of Nox2 and -4, ET-1, VEGF, TGF-beta, CTGF, and oxidant production...
  20. ncbi Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model
    Matthias Meier
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Diabetes 56:346-54. 2007
    ....
  21. doi PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia
    Claudia Holler
    Laboratory for Immunological and Molecular Cancer Research, 3rd Medical Department for Hematology, Oncology, Hemostasiology, Infectious Diseases and Rheumatology, University Hospital Salzburg, Salzburg, Austria
    Blood 113:2791-4. 2009
    ..Moreover, targeting of PKCbeta with the specific inhibitor enzastaurin led to killing of human CLL samples in vitro. We thus propose that PKCbeta may be a relevant target for the treatment of CLL...
  22. pmc Protein kinase Cbeta is an effective target for chemoprevention of colon cancer
    Alan P Fields
    Departments of Cancer Biology and Pathology, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    Cancer Res 69:1643-50. 2009
    ..Thus, PKCbetaII is an important target for colon cancer chemoprevention and the PKCbeta-selective inhibitor enzastaurin may represent an effective chemopreventive agent in patients at high risk for colon cancer...
  23. pmc Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance
    Wei Huang
    Department of Molecular and Cellular Biochemistry, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Hepatology 49:1525-36. 2009
    ....
  24. pmc Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain
    Anita M Hennige
    University of Tuebingen, Department of Internal Medicine, Tubingen, Germany
    J Cell Mol Med 14:903-13. 2010
    ....
  25. pmc Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held
    Diasynou Fioravante
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 70:1005-19. 2011
    ..These experiments establish that PKCα and PKCβ are crucial for PTP and suggest that long-lasting presynaptic calcium increases produced by tetanic stimulation may activate these isoforms to produce PTP...
  26. pmc Protein kinase Cβ deficiency attenuates obesity syndrome of ob/ob mice by promoting white adipose tissue remodeling
    Wei Huang
    Department of Molecular and Cellular Biochemistry, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, 1645 Neil Avenue, Columbus, OH 43210, USA
    J Lipid Res 53:368-78. 2012
    ..Collectively, these findings suggest that PKCβ deficiency may prevent genetic obesity, in part, by remodeling the catabolic function of adipose tissues through β-ARs dependent and independent mechanisms...
  27. pmc Adaptive regulation maintains posttetanic potentiation at cerebellar granule cell synapses in the absence of calcium-dependent PKC
    Diasynou Fioravante
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 32:13004-9. 2012
    ..These results suggest that a feedback mechanism allows granule cells to maintain the normal properties of short-term synaptic plasticity even when the mechanism that mediates PTP in wild-type mice is eliminated...
  28. pmc Calcium-dependent PKC isoforms have specialized roles in short-term synaptic plasticity
    Yunxiang Chu
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 82:859-71. 2014
    ..In hearing animals, virally expressed PKCγ overrides PKCβ to produce PTP by increasing p. Thus, two similar PKC isoforms mediate PTP in distinctly different ways...
  29. pmc Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization
    Kiyoshi Suzuma
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:721-6. 2002
    ..dramatic increase in the angiogenic response to oxygen-induced retinal ischemia in transgenic mice overexpressing PKC beta 2 isoform and a significant decrease in retinal neovascularization in PKC beta isoform null mice...
  30. ncbi Cloning of a mouse protein kinase A catalytic subunit pseudogene and chromosomal mapping of C subunit isoforms
    D E Cummings
    Department of Pharmacology, University of Washington, Seattle 98195
    Mamm Genome 5:701-6. 1994
    ..This is displaced from its functional homologs, C alpha and C beta, which we map to mouse Chrs 8 (band C3) and 3 (band H3), respectively...
  31. pmc Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy
    H Wakasaki
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 94:9320-5. 1997
    ..These findings have firmly established that the activation of the PKCbeta2 isoform can cause specific cardiac cellular and functional changes leading to cardiomyopathy of diabetic or nondiabetic etiology...
  32. ncbi Protein kinase C-beta and oxygen deprivation. A novel Egr-1-dependent pathway for fibrin deposition in hypoxemic vasculature
    S F Yan
    Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Biol Chem 275:11921-8. 2000
    ....
  33. ncbi Participation of phospholipase D and alpha/beta-protein kinase C in growth factor-induced signalling in C3H10T1/2 fibroblasts
    Vidar A T Thorsen
    Department of Biochemistry and Molecular Biology, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Biochim Biophys Acta 1632:62-71. 2003
    ..These findings place PLD as an important component in PDGF-BB- and PMA-stimulated intracellular signalling leading to gene activation in Cl8 cells, while EGF does not require PLD...
  34. ncbi Dkk3-Cre BAC transgenic mouse line: a tool for highly efficient gene deletion in retinal progenitor cells
    Shigeru Sato
    Department of Developmental Biology, Osaka Bioscience Institute, Suita, Osaka, Japan
    Genesis 45:502-7. 2007
    ..Thus, the BAC-Dkk3-Cre transgenic mouse line provides a powerful tool for generating conditional knockout mouse lines for studying loss of gene functions in the developing retina...
  35. doi PKCbeta modulates ischemia-reperfusion injury in the heart
    Linghua Kong
    Dept of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Am J Physiol Heart Circ Physiol 294:H1862-70. 2008
    ..These data implicate PKCbeta in I/R-mediated myocardial injury, at least in part via phosphorylation of JNK, and suggest that blockade of PKCbeta may represent a potent strategy to protect the vulnerable myocardium...
  36. pmc Reduction of PKCbetaII activity in smooth muscle cells attenuates acute arterial injury
    Chun Huang
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA
    Atherosclerosis 212:123-30. 2010
    ....
  37. doi Protein kinase C βII and δ/θ play critical roles in bone morphogenic protein-4-stimulated osteoblastic differentiation of MC3T3-E1 cells
    Ki Ho Park
    Department of Orthodontics Kyung Hee University School of Dentistry, Seoul 130 701, Republic of Korea
    Biochem Biophys Res Commun 403:7-12. 2010
    ..Taken together, our findings suggest that PKC βII and PKC δ/θ mediate BMP-4-induced osteoblastic differentiation...
  38. pmc Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction
    Sang Ki Lee
    Infection Signaling Network Research Center, Research Institute of Medical Sciences, Department of Physiology, School of Medicine, Chungnam National University, 6 Munhwa dong, Jung Gu, Daejeon, Korea
    Cardiovasc Res 91:502-9. 2011
    ....
  39. pmc Protein kinase Cβ is required for lupus development in Sle mice
    David Oleksyn
    University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Rheum 65:1022-31. 2013
    ..To evaluate the requirement for protein kinase Cβ (PKCβ) in the development of lupus in mice, and to explore the potential of targeting PKCβ as a therapeutic strategy in lupus...
  40. pmc Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation
    C E Teh
    Ramaciotti Immunization Genomics Laboratory, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Genes Immun 14:223-33. 2013
    ..These results, coupled with evidence of numerous mis-sense PRKCB mutations in the human genome, identify Prkcb as a genetically sensitive step likely to contribute substantially ..
  41. pmc A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts
    Mathieu Ferron
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Genes Dev 27:955-69. 2013
    ..Altogether, these results uncover a RANKL-dependent signaling pathway taking place in differentiated osteoclasts and culminating in the activation of TFEB to enhance lysosomal biogenesis-a necessary step for proper bone resorption...
  42. pmc Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence
    Joseph A Brzezinski
    Department of Ophthalmology University of Colorado School of Medicine, Aurora, CO 80045, USA Electronic address
    Dev Biol 384:194-204. 2013
    ..Blimp1 likely forms a cross-repressive network with pro-bipolar factors such that the winner of this interaction stabilizes the photoreceptor or bipolar state, respectively. ..
  43. pmc Exercise protects against diet-induced insulin resistance through downregulation of protein kinase Cβ in mice
    Xiaoquan Rao
    College of Public Health, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 8:e81364. 2013
    ..These results suggest that downregulation of PKCβ contributes to exercise-induced improvement of insulin resistance in HFD-fed mice. ..
  44. doi Selective inhibition of protein kinase C β2 attenuates the adaptor P66 Shc-mediated intestinal ischemia-reperfusion injury
    Z Chen
    Department of General Surgery, Second Affiliated Hospital, Dalian Medical University, 116023 Dalian, China
    Cell Death Dis 5:e1164. 2014
    ..This may represent a novel therapeutic approach for the prevention of intestinal I/R injury. ..
  45. ncbi Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a
    H Wada
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Biochem Biophys Res Commun 165:533-8. 1989
    ..Human lymphoid cell lines express large amounts of PKC beta mRNAs in addition to PKC alpha. Further, nPKC epsilon mRNA is expressed in some of these cell lines...
  46. ncbi Developmental expression of MARCKS and protein kinase C in mice in relation to the exencephaly resulting from MARCKS deficiency
    P J Blackshear
    Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Dev Brain Res 96:62-75. 1996
    ....
  47. pmc Mobilization of protein kinase C in macrophages induced by Listeria monocytogenes affects its internalization and escape from the phagosome
    Sandra J Wadsworth
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6076, USA
    Infect Immun 70:4650-60. 2002
    ..for translocation of protein kinase C delta (PKC delta) to the periphery of J774 cells and for translocation of PKC beta II to early endosomes beginning within the first minute after addition of bacteria to the culture medium...
  48. ncbi Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells
    Shangwu Chen
    Immunology Group, Institute of Cell and Molecular Sciences, St Barts and The Royal London School of Medicine, Queen Mary University of London, London EC1A 7BE, UK
    Int Immunol 15:403-9. 2003
    ..These results suggest that CIS regulates PKC activation, and that this may be important for the activation of both the AP-1 and NF-kappaB pathways in TCR signaling...
  49. ncbi Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia
    Takehiko Ueyama
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan
    J Immunol 173:4582-9. 2004
    ..This study also suggests that DGKbeta plays a prominent role in regulation of O(2)(-) production during FcgammaR-mediated phagocytosis...
  50. ncbi Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase
    Dan Chen
    Department of Pharmacology, Molecular Pathology Graduate Program, University of California at San Diego, La Jolla, California 92093 0721, USA
    J Biol Chem 282:33776-87. 2007
    ..Our data reveal a novel mechanism that provides amplitude control in PKC signaling through ubiquitination catalyzed by RINCK, an E3 ligase that specifically recognizes the C1 domain of PKC isoforms...
  51. ncbi Inhibition of protein kinase C β ameliorates impaired angiogenesis in type I diabetic mice complicating myocardial infarction
    Akihiko Ikeda
    Department of Cardiovascular Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Circ J 76:943-9. 2012
    ..In recent studies, the inhibition of protein kinase C (PKC) β has been shown to improve diabetic vascular complications. However, the effect on angiogenesis in myocardial ischemia with diabetes mellitus (DM) is still unknown...
  52. pmc Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes
    Hilde Abrahamsen
    Department of Pharmacology, Graduate Program, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 287:13262-78. 2012
    ....
  53. doi PKC signaling inhibits osteogenic differentiation through the regulation of Msx2 function
    Hyung Min Jeong
    Chonnam National University, Gwangju, Republic of Korea
    Biochim Biophys Acta 1823:1225-32. 2012
    ..In addition, PKC prolonged the half-life of Msx2 protein. These results suggest that PKC signaling modulates osteoblast differentiation, at least in part, through the regulation of Msx2...
  54. pmc A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity
    Carrie N Arnold
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 109:12286-93. 2012
    ..All of the mutations identified to date directly affect lymphocyte development or function; none have an exclusive effect on cells of the innate immune system...
  55. pmc Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo
    Gloria Lutzny
    Department of Hematology, Oncology, Technical University, 81675 Munich, Germany
    Cancer Cell 23:77-92. 2013
    ..Upregulated stromal PKC-βII in biopsies from patients with CLL, acute lymphoblastic leukemia, and mantle cell lymphoma suggests that this pathway may commonly be activated in a variety of hematological malignancies...
  56. pmc Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: differences between oligopeptide and polypeptide phosphorylation
    S A Oehrlein
    Institute of Physiological Chemistry, Johannes Gutenberg University, Mainz, Germany
    Biochem J 317:219-24. 1996
    ..Here we describe the phosphorylation by and the site specificity of different PKC isotypes. The conventional PKC beta 1 and the novel PKCs delta and epsilon effectively phosphorylated recombinant GAP-43 in vitro; atypical PKC zeta ..
  57. pmc Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens
    Maria Almeida
    University of Arkansas for Medical Sciences, Division of Endocrinology and Metabolism, Little Rock, Arkansas 72205 7199, USA
    Mol Endocrinol 24:2030-7. 2010
    ....
  58. doi High-molecular weight hyaluronan reduced renal PKC activation in genetically diabetic mice
    Giuseppe M Campo
    Department of Biochemical, Physiological and Nutritional Sciences, section of Medical Chemistry, School of Medicine, University of Messina, Policlinico Universitario, Messina, Italy
    Biochim Biophys Acta 1802:1118-30. 2010
    ..These results suggest that the CD44 and PKC play an important role in diabetes and interaction of high-molecular weight HA with these proteins may reduce inflammation and secondary pathologies due to this disease...
  59. pmc DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex
    Dongman Chao
    The Third Medical College of Soochow University, Changzhou, Jiangsu 213003, PR China
    Exp Neurol 236:228-39. 2012
    ..We conclude that DOR activation inhibits anoxia-induced Na(+) influx through Na(+) channels via PKC (especially PKCβII and PKCθ isoforms) dependent mechanisms in the cortex...
  60. pmc PKCβ promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice
    Linghua Kong
    Diabetes Research Program, Division of Endocrinology, Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
    Arterioscler Thromb Vasc Biol 33:1779-87. 2013
    ..Because the metabolism of glucose results in production of activators of protein kinase C (PKC)β, it was logical to investigate the role of PKCβ in modulation of atherosclerosis in diabetes mellitus...
  61. pmc Isolation of cloned mouse protein kinase C beta-II cDNA and its sequence
    Y M Tang
    Department of Medicinal Chemistry and Pharmacognosy, Purdue University School of Pharmacy, West Lafayette, IA 47907
    Nucleic Acids Res 18:5310. 1990
  62. ncbi A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells
    K Akimoto
    Department of Molecular Biology, Yokohama City University School of Medicine, Japan
    J Biol Chem 269:12677-83. 1994
    ..These results, in conjunction with the results obtained in parallel experiments with PKC zeta and other PKC members, suggest a biochemical similarity between PKC lambda and zeta and their clear difference from other PKC members...
  63. ncbi Distribution of the extended family of protein kinase C isoenzymes in fetal organs of mice: an immunohistochemical study
    R Bareggi
    Dipartimento di Morfologia Umana Normale, Universita degli Studi di Trieste, Italy
    Cell Tissue Res 280:617-25. 1995
    ..One set of antisera was employed to investigate the distribution of the isoforms in selected organs from an earlier developmental age (15 days) and from adult animals.(ABSTRACT TRUNCATED AT 250 WORDS)..
  64. ncbi Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice
    B J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
    J Neurochem 64:2737-46. 1995
    ....
  65. ncbi The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis
    F Zappelli
    Institute of Histology and General Embryology, University of Rome La Sapienza, Italy
    Dev Biol 180:156-64. 1996
    ..They also suggest a specific role for protein kinase C theta in determining the fate of different myoblasts during muscle histogenesis...
  66. ncbi Two novel brain-specific splice variants of the murine Cbeta gene of cAMP-dependent protein kinase
    C R Guthrie
    Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 272:29560-5. 1997
    ..The discrete expression of Cbeta variants in the brain suggests specific functional roles in neuronal signaling...
  67. pmc Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates
    J C Bowman
    Department of Medicine, Albert Einstein College of Medicine, New York, NY 10461, USA
    J Clin Invest 100:2189-95. 1997
    ..Thus, the PKC signaling pathway in cardiocytes has different effects depending on the timing of expression and, in the adult, is sufficient to induce pathologic hypertrophy...
  68. ncbi Distinct functions of protein kinase Calpha and protein kinase Cbeta during retinoic acid-induced differentiation of F9 cells
    Y Cho
    Institute of Human Nutrition, Columbia University, New York, New York 10032, USA
    Cell Growth Differ 9:147-54. 1998
    ....
  69. pmc Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis
    N R Murray
    Sealy Center for Oncology and Hematology, University of Texas Medical Branch, Galveston, Texas 77555 1048, USA
    J Cell Biol 145:699-711. 1999
    ..These data demonstrate a direct role for PKC betaII in colonic epithelial cell proliferation and colon carcinogenesis, possibly through activation of the APC/beta-catenin signaling pathway...
  70. ncbi Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C
    Q Zhou
    Department of Medicine, UCSD Salk Program in Molecular Medicine, University of California at San Diego, School of Medicine, La Jolla, California 92093 0613, USA
    J Biol Chem 274:19807-13. 1999
    ..Together, our data suggest that Cypher1 may function as an adaptor in striated muscle to couple protein kinase C-mediated signaling, via its LIM domains, to the cytoskeleton (alpha-actinin-2) through its PDZ domain...
  71. pmc Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery
    R Tian
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:13536-41. 1999
    ..Furthermore, our results suggest that mechanisms other than reduced acidification and preservation of high-energy phosphate levels during ischemia contribute to the improved recovery...
  72. ncbi Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development
    G Balasubramanian
    Department of Veterinary Biomedical Sciences, University of Missouri Columbia, 65211, USA
    J Craniofac Genet Dev Biol 20:26-34. 2000
    ....
  73. ncbi Enhancement of L-type Ca(2+) current from neonatal mouse ventricular myocytes by constitutively active PKC-betaII
    Kris J Alden
    Department of Physiology and Biophysics, Department of Medicine, College of Medicine, University of Illinois at Chicago, 900 S Ashland Ave, Chicago, IL 60607, USA
    Am J Physiol Cell Physiol 282:C768-74. 2002
    ..Thus these data demonstrate that PKC-beta is a potent modulator of cardiac L-type calcium channels and that this specific isoform increases I(Ca) in neonatal ventricular myocytes...
  74. ncbi PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells
    Wei Li Wang
    Department of Biochemistry, National Yang Ming University, Taipei, 112, Taiwan
    J Biol Chem 278:37705-12. 2003
    ..These findings indicate a previously unidentified role for PICK1 in anchoring PKCalpha to mitochondria in a ligand-specific manner...
  75. ncbi High concentration of glucose inhibits glomerular endothelial eNOS through a PKC mechanism
    Shaoyou Chu
    Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Am J Physiol Renal Physiol 287:F384-92. 2004
    ..The consequence is a rapid decline in the generation of NO in the glomerular endothelial cells in the presence of a high concentration of glucose...
  76. pmc PKCbeta regulates ischemia/reperfusion injury in the lung
    Tomoyuki Fujita
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 113:1615-23. 2004
    ..These findings elucidate key roles for PKCbetaII activation in I/R by coordinated activation of MAPKs (ERK1/2, JNK) and Egr-1...
  77. ncbi Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40
    Niketa A Patel
    Department of Biochemistry, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 280:14302-9. 2005
    ..This model is upheld in Akt2-deficient mice with insulin resistance leading to diabetes mellitus...
  78. ncbi Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:4495-504. 2005
    ..Thus, binding of HC IgEs to Fc epsilon RI induces adhesion of mast cells to fibronectin by modulating cellular activation signals in a unique fashion...
  79. ncbi Critical role of protein kinase C betaII in activation of mast cells by monomeric IgE
    Ying Liu
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 280:38976-81. 2005
    ..Expression of PKCbetaII/T500V was found not to affect the antigen-induced responses. These results suggest that PKCbetaII plays a critical role in monomeric IgE responses, but not in antigen responses...
  80. ncbi Expression profile of protein kinase C isozymes in preimplantation mouse development
    Hesam Dehghani
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, N1G 2W1 Canada
    Reproduction 130:441-51. 2005
    ....
  81. ncbi Protein kinase C alpha, betaI, and betaII isozymes regulate cytokine production in mast cells through MEKK2/ERK5-dependent and -independent pathways
    Guiming Li
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Cell Immunol 238:10-8. 2005
    ..Since MAPK modules differentially regulate mast cell functions, including degranulation and cytokine production, it is suggested that specific functions could be targeted by inhibiting specific PKC isoforms...
  82. ncbi Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium
    Seigo Itoh
    Cardiovascular Research Institute, University of Rochester, Rochester, NY, USA
    Circulation 113:1787-98. 2006
    ....
  83. ncbi Selective regulation of IL-10 signaling and function by zymosan
    Zhimei Du
    Graduate Program in Immunology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    J Immunol 176:4785-92. 2006
    ..The fate of individual cells in an inflammatory microenvironment is thus specified by dynamic interactions among host cells, microbes, and cytokines that determine the balance between protection and pathology...
  84. ncbi Control of cardiac myofilament activation and PKC-betaII signaling through the actin capping protein, CapZ
    W Glen Pyle
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Mol Cell Cardiol 41:537-43. 2006
    ....
  85. ncbi PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144
    Hao Wang
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    J Mol Cell Cardiol 41:823-33. 2006
    ....
  86. ncbi Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn
    Benchang Guo
    Center for Oncology and Cell Biology, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 178:4726-30. 2007
    ..These results indicate that the rottlerin-sensitive, Lyn-dependent alternate pathway, and the classical pathway, for BCR signaling operate in parallel when BCR engagement follows IL-4 exposure...
  87. ncbi The PKC pathway and in particular its beta1 isoform is clearly involved in meiotic arrest maintenance but poorly in FSH-induced meiosis resumption of the mouse cumulus cell enclosed oocyte
    Anne Denys
    INSERM ERI 18, Universite Paris 13, Bobigny, France
    Mol Reprod Dev 74:1575-80. 2007
    ..The results show that whereas the PKC pathway is clearly involved in maintenance of the meiotic arrest through PKCbeta1, it is not involved in FSH-induced meiosis of CEOs...
  88. ncbi Protein kinase C deficiency increases fatty acid oxidation and reduces fat storage
    Rishipal R Bansode
    Departments of Molecular and Cellular Biochemistry and Medicine, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, 1645 Neil Avenue, Columbus, OH 43210, USA
    J Biol Chem 283:231-6. 2008
    ..The ability of PKCbeta deficiency to promote fat burning in adipocytes may suggest novel therapeutic strategies for obesity and obesity-related disorders...
  89. doi Role of protein kinase C in selective inhibition of mouse retinal neurites during contacts with chondroitin sulfates
    Joyce Shi Ying Lam
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Neurosci Lett 434:150-4. 2008
    ....
  90. doi mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice
    Jian Xin Liu
    Epilepsy Research Laboratory, National Neuroscience Institute, Singapore, Singapore
    Epilepsy Res 82:111-23. 2008
    ..It is possible that mGluR5 may play a negative role in initiation of status epilepticus by interacting with muscarinic acetylcholine receptor in mGluR5+/+ mice...
  91. pmc Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function
    Debra L Rigor
    Cardiovascular Division, Beth Israel Deaconess Medical Center, 3 Blackfan Circle, Rm 910, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 296:H566-72. 2009
    ....
  92. doi Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model
    Valeria C Grossoni
    Research Area, Institute of Oncology Angel H Roffo, University of Buenos Aires, Av San Martin 5481, C1417DTB, Buenos Aires, Argentina
    Breast Cancer Res Treat 118:469-80. 2009
    ..Our results suggest PKCbeta1 functions as an inhibitory protein for tumor growth and metastasis dissemination whereas PKCepsilon drives metastatic dissemination without affecting primary tumor growth...
  93. pmc Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression
    Nicole R Murray
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    Cancer Res 69:656-62. 2009
    ..Thus, PKCbetaII and PKCiota, whose expression is elevated in both rodent and human colon tumors, collaborate to drive colon tumor formation and progression, respectively...
  94. doi Steel factor enhances supraoptimal antigen-induced IL-6 production from mast cells via activation of protein kinase C-beta
    Kerstin Fehrenbach
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Albert Ludwigs University Freiburg, Freiburg, Germany
    J Immunol 182:7897-905. 2009
    ..Thus, PKC-beta joins PI3K and Btk as important players in this synergistic MC activation...
  95. pmc Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach
    Qinghang Liu
    Children s Hospital Medical Center, Division of Molecular Cardiovascular Biology, 3333 Burnet Ave, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    Circ Res 105:194-200. 2009
    ....
  96. pmc Developmentally spliced PKCbetaII provides a possible link between mTORC2 and Akt kinase to regulate 3T3-L1 adipocyte insulin-stimulated glucose transport
    E Kleiman
    Department of Molecular Medicine, College of Medicine, University of South Florida, The Research Service, James A Haley Veterans Hospital, Tampa, FL 33612, USA
    Biochem Biophys Res Commun 388:554-9. 2009
    ..PKCbetaII regulates GLUT4 translocation by regulating Akt phosphorylation and thus activity...
  97. pmc Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin
    Takashi Yamamoto
    Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Lipid Res 51:1859-70. 2010
    ..This new understanding of PKCbeta involvement in nutritional regulation of SREBP-1c activation provides a new aspect of PKCbeta inhibition as a potential therapeutic target for diabetic complications...
  98. doi Protein kinase C regulates rod photoreceptor differentiation through modulation of STAT3 signaling
    Carolina Pinzon-Guzman
    Department of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA 17033, USA
    Adv Exp Med Biol 664:21-8. 2010
    ..In addition, inhibition of PKC results in increase STAT3 phosphorylation. We suggest that cross talk of signals between STAT3 and PKC may determine the differentiation of rods from retinal progeitors...
  99. pmc Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability
    Pan Yue Deng
    Department of Pharmacology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58203, USA
    J Neurosci 30:5136-48. 2010
    ..CCK released endogenously from hippocampal interneurons facilitated glutamatergic transmission. Our results provide a cellular and molecular mechanism to explain the roles of CCK in the brain...
  100. pmc eEF1A phosphorylation in the nucleus of insulin-stimulated C2C12 myoblasts: Ser⁵³ is a novel substrate for protein kinase C βI
    Manuela Piazzi
    Cellular Signaling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Mol Cell Proteomics 9:2719-28. 2010
    ..In-depth analysis using site-directed mutagenesis revealed that PKCβI could phosphorylate Ser⁵³ of the eEF1A2 isoform and that the association between eEF1A2 and PKCβI was dependent on the phosphorylation status of eEF1A2...
  101. pmc Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting
    Nicole Joller
    Institute for Microbiology, Eidgenössiche Technische Hochschule Zurich, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 107:20441-6. 2010
    ..Based on these findings, we propose a mechanism whereby Abs and FcR engagement subverts the strategies by which intracellular bacterial pathogens evade lysosomal degradation...

Research Grants12

  1. Retinal imaging tests for microvascular functions
    George King; Fiscal Year: 2003
    ..These studies should provide us with information on whether retinal neural and vascular imaging function tests can be related to peripheral neural and microvascular dysfunctions and pathologies in diabetic patients. ..
  2. HYPERGLYCEMIA INHIBITION OF GLOMERULAR eNOS
    Shaoyou Chu; Fiscal Year: 2004
    ....
  3. ENDOTHELIN EFFECTS ON RETINAL CELLS AND BLOOD FLOW
    George King; Fiscal Year: 2001
    ....
  4. CELL BIOLOGY APPROACH TO DIABETIC RETINOPATHY
    George King; Fiscal Year: 2001
    ..effects through the activation of diacylglycerol-protein kinase C (DAG-PKC) pathway involving predominately PKC beta isoform which has been reported to increase extracellular matrix production, growth factor expression, and enzyme ..
  5. GLUCOSE UTILIZATION IN SENESCENT HEARTS
    Rong Tian; Fiscal Year: 2002
    ..Aim 4: To test the hypothesis that presence of high glucose and insulin increase glucose utilization and improves the tolerance toischemia in senescent hearts. ..
  6. Enhanced Program for Human Subject Protection
    George King; Fiscal Year: 2002
    ..III. To provide secure record storage facilities within existing research space by renovating currently unusable space. ..
  7. Monocyte VEGF & PKC, Markers for Diabetic Complications
    George King; Fiscal Year: 2003
    ..These data can provide definitive evidence to determine whether further studies are needed to establish these two parameters in the circulating monocyte as surrogate markers of diabetic microvascular diseases. ..
  8. ANIMAL RESOURCES FACILITY EQUIPMENT IMPROVED PROJECT
    George King; Fiscal Year: 2004
    ..Not only will the requested improvements impact animal welfare, but they will also benefit the efficiency of the research animal program. ..
  9. PROTEIN KINASE C ACTIVATION AND DIABETIC CARDIOMYOPATHY
    George King; Fiscal Year: 2004
    ..Isolated cardiornyocytes from PKCB transgenic mice contracted poorly which was corrected by specific inhibitor (LY333531) to PKCB isoforms...
  10. Early Growth Response-1 (Egr-1), PKC Beta and Restenosis
    Shi Fang Yan; Fiscal Year: 2007
    ..focused on the role of the immediate early gene, early growth response-1 (egr-1) and its key upstream regulator, PKCb, in the response to acute arterial injury...
  11. PKC Activation and Cardiovascular Disease in Diabetes
    George King; Fiscal Year: 2007
    ..2) to assess the role of PKC beta isoform activation in the development of atherosclerosis in apoE-KO mice by comparing the atherosclerotic lesions ..
  12. Egr-1, PKC Beta, Signalling and Atherosclerosis
    Shi Fang Yan; Fiscal Year: 2009
    ....