Prkg1

Summary

Gene Symbol: Prkg1
Description: protein kinase, cGMP-dependent, type I
Alias: AW125416, CGKI, Gm19690, Prkg1b, Prkgr1b, cGMP-dependent protein kinase 1, cGK 1, cGK1, cGMP-dependent protein kinase I
Species: mouse

Top Publications

  1. pmc Regulate axon branching by the cyclic GMP pathway via inhibition of glycogen synthase kinase 3 in dorsal root ganglion sensory neurons
    Zhen Zhao
    Zilkha Neurogenetic Institute, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 29:1350-60. 2009
  2. pmc Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration
    You Yang Zhao
    Department of Pharmacology and 2Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois, USA
    J Clin Invest 119:2009-18. 2009
  3. ncbi Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase
    Christian Keicher
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Biochem Biophys Res Commun 324:308-16. 2004
  4. ncbi Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II
    A Pfeifer
    Institut f ur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Strasse 29, D 80802 M unchen, Germany
    Science 274:2082-6. 1996
  5. pmc Defective smooth muscle regulation in cGMP kinase I-deficient mice
    A Pfeifer
    Institut fur Pharmakologie und Toxikologie, Munchen, Biedersteiner, Str 29, 80802 Müchen, Germany
    EMBO J 17:3045-51. 1998
  6. ncbi Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha
    K Yuasa
    Discovery Research Laboratory, Tanabe Seiyaku Co Ltd, 2 50 Kawagishi 2 chome, Toda, Saitama 335 8505, Japan
    J Biol Chem 275:4897-905. 2000
  7. ncbi cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium
    Jörg W Wegener
    Pharmakologisches Institut, Universitat Mainz, Germany
    Circ Res 90:18-20. 2002
  8. pmc cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons
    Hannes Schmidt
    Developmental Neurobiology Group, Medical Research Council, Max Delbruck Centrum fur Molekulare Medizin, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    J Cell Biol 159:489-98. 2002
  9. ncbi A stimulatory role for cGMP-dependent protein kinase in platelet activation
    Zhenyu Li
    Department of Pharmacology, College of Medicine, University of Illinois, 835 South Wolcott Avenue, Chicago, IL 60612, USA
    Cell 112:77-86. 2003
  10. pmc Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration
    Kenichi Yamahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 100:3404-9. 2003

Research Grants

  1. REACTIVE OXYGEN SPECIES AND VASCULAR O2 SENSING
    Michael S Wolin; Fiscal Year: 2010
  2. PULMONARY VASODILATION AND GUANYLATE CYCLASE REGULATION
    Michael S Wolin; Fiscal Year: 2010

Scientific Experts

  • Shuxia Wang
  • C A Cobine
  • Michael Wolin
  • Ceng Luo
  • Keizo Yuasa
  • Robert Lukowski
  • Pascal Weinmeister
  • Eiki Takimoto
  • Charlotte Wagner
  • Achim Schmidtko
  • Ramaswamy Ramchandran
  • You Yang Zhao
  • A Pfeifer
  • T Kleppisch
  • Małgorzata Chalimoniuk
  • Irmgard Tegeder
  • Franz Hofmann
  • Robert Feil
  • Susanne Feil
  • Jens Schlossmann
  • Jörg W Wegener
  • Michael Klaiber
  • Veronika Leiss
  • Lutz Birnbaumer
  • Hannes Schmidt
  • Zhen Zhao
  • Katrin Domes
  • Olena Rudyk
  • Stefan Frantz
  • David A Kass
  • René Wörner
  • Katharina Völker
  • Michaela Kuhn
  • Marc Freichel
  • Bodo Haas
  • Jesse D Roberts
  • Michael E Mendelsohn
  • Andrea Gerling
  • Nadejda Valtcheva
  • Zhenyu Li
  • Fritz G Rathjen
  • Naoki Sawada
  • Wiebke Wolfsgruber
  • Yasutoshi Ando
  • Stefanie Wolfertstetter
  • Kinya Seo
  • Wenpeng Cui
  • Gohar Ter-Avetisyan
  • F Hofmann
  • Florian Loga
  • Lin Zhang
  • Michaela M Mitschke
  • Shin Kato
  • Robert M Blanton
  • Sabine Klein
  • Philip Eaton
  • Elisabeth Schinner
  • Peter Ruth
  • Oleksandra Prysyazhna
  • Kenichi Yamahara
  • Jiqian Huang
  • Heike Oberwinkler
  • Joseph Robert Burgoyne
  • Paul Markus Müller
  • Hideo A Baba
  • Matthias Werner
  • Alexander Dietrich
  • Stefan Z Lutz
  • Peter Mayer
  • Daniela Scholz
  • Dejan M Nikolic
  • Janica C Wong
  • Claudia Ertl
  • Mark Aronovitz
  • Richard H Karas
  • Olaf Pongs
  • Martin Kruse
  • R Scott Stephens
  • Norimichi Koitabashi
  • Hiroki Toyoda
  • Christian K Nickl
  • Cindy Paul
  • Anne Marie Duchemin
  • Matthias Desch
  • Patricia R Bachiller
  • Steffen Massberg
  • Martin Thunemann
  • R Fassler
  • Andrea Tedeschi
  • Sonja Langmesser

Detail Information

Publications102 found, 100 shown here

  1. pmc Regulate axon branching by the cyclic GMP pathway via inhibition of glycogen synthase kinase 3 in dorsal root ganglion sensory neurons
    Zhen Zhao
    Zilkha Neurogenetic Institute, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 29:1350-60. 2009
    ..At the molecular level, the cGMP-dependent protein kinase 1 (PrkG1) mediates this activity, as DRG neurons isolated from the kinase-deficient mouse fail to respond to cGMP ..
  2. pmc Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration
    You Yang Zhao
    Department of Pharmacology and 2Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois, USA
    J Clin Invest 119:2009-18. 2009
    ..Thus, targeting of PKG nitration represents a potential novel therapeutic strategy for the treatment of PH...
  3. ncbi Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase
    Christian Keicher
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Biochem Biophys Res Commun 324:308-16. 2004
    ..Immunoblotting of LASP-1 in various mouse and human tissues detected a similar prominent expression in non-muscle tissue. Altogether, our data suggest so far no functional differences between human and mouse LASP-1...
  4. ncbi Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II
    A Pfeifer
    Institut f ur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Strasse 29, D 80802 M unchen, Germany
    Science 274:2082-6. 1996
    ..The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes...
  5. pmc Defective smooth muscle regulation in cGMP kinase I-deficient mice
    A Pfeifer
    Institut fur Pharmakologie und Toxikologie, Munchen, Biedersteiner, Str 29, 80802 Müchen, Germany
    EMBO J 17:3045-51. 1998
    ..cGMP-dependent protein kinase I (cGKI) has been suggested as a major mediator of the relaxant effects of both nucleotides...
  6. ncbi Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha
    K Yuasa
    Discovery Research Laboratory, Tanabe Seiyaku Co Ltd, 2 50 Kawagishi 2 chome, Toda, Saitama 335 8505, Japan
    J Biol Chem 275:4897-905. 2000
    ..These findings suggest that GKAP42 functions as an anchoring protein for cGK-Ialpha and that cGK-Ialpha may participate in germ cell development through phosphorylation of Golgi-associated proteins such as GKAP42...
  7. ncbi cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium
    Jörg W Wegener
    Pharmakologisches Institut, Universitat Mainz, Germany
    Circ Res 90:18-20. 2002
    To study the role of cGMP-dependent protein kinase I (cGKI) for cardiac contractility, force of contraction (F(c)) was studied in electrically driven heart muscle from wild-type (WT) mice and from conventional and conditional cGKI ..
  8. pmc cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons
    Hannes Schmidt
    Developmental Neurobiology Group, Medical Research Council, Max Delbruck Centrum fur Molekulare Medizin, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    J Cell Biol 159:489-98. 2002
    ..cGMP is a second messenger with several distinct targets including cGMP-dependent protein kinase I (cGKI)...
  9. ncbi A stimulatory role for cGMP-dependent protein kinase in platelet activation
    Zhenyu Li
    Department of Pharmacology, College of Medicine, University of Illinois, 835 South Wolcott Avenue, Chicago, IL 60612, USA
    Cell 112:77-86. 2003
    ..The cGMP-stimulated platelet responses are biphasic, consisting of an initial transient stimulatory response that promotes platelet aggregation and a subsequent inhibitory response that limits the size of thrombi...
  10. pmc Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration
    Kenichi Yamahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 100:3404-9. 2003
    ....
  11. pmc A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells
    Wiebke Wolfsgruber
    Institut fur Pharmakologie und Toxikologie, Technische Universitat, Biedersteiner Strasse 29, 80802 Munich, Germany
    Proc Natl Acad Sci U S A 100:13519-24. 2003
    ..The cGMP-dependent protein kinase I (cGKI) is a potential mediator of NO signaling in vascular smooth muscle cells (SMCs)...
  12. pmc Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Proc Natl Acad Sci U S A 101:3253-7. 2004
    ..The paucity of substance P in laminae I-III may contribute to the reduction of nociception in PKG-I(-/-) mice and suggests a role of PKG-I in substance P synthesis...
  13. ncbi Compartmentalization of cardiac beta-adrenergic inotropy modulation by phosphodiesterase type 5
    Eiki Takimoto
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Circulation 115:2159-67. 2007
    ..The potential role of differential cGMP and protein kinase G stimulation by these 2 modulators was also studied...
  14. ncbi Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme
    Silke Weber
    Institut für Pharmakologie und Toxikologie der Technischen Universität, Biedersteiner Str 29, D 80802 München, Germany
    Circ Res 101:1096-103. 2007
    ..Inactivation of the murine cGKI gene prkg1 leads to multiple phenotypes and premature death at approximately 6 weeks...
  15. pmc The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord
    Hannes Schmidt
    Max Delbruck Centrum fur Molekulare Medizin, Berlin D 13092, Germany
    J Cell Biol 179:331-40. 2007
    ..inactive receptor guanylyl cyclase Npr2 or deficient for cyclic guanosine monophosphate-dependent protein kinase I (cGKI) lack the bifurcation of sensory axons at the DREZ, i.e., the ingrowing axon either turns rostrally or caudally...
  16. pmc Anemia and splenomegaly in cGKI-deficient mice
    Michael Foller
    Department of Physiology, Interfakultäres Institut für Biochemie, University of Tubingen, D72076 Tübingen, Germany
    Proc Natl Acad Sci U S A 105:6771-6. 2008
    To explore the functional significance of cGMP-dependent protein kinase type I (cGKI) in the regulation of erythrocyte survival, gene-targeted mice lacking cGKI were compared with their control littermates...
  17. pmc High blood pressure arising from a defect in vascular function
    Simon K Michael
    Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 105:6702-7. 2008
    ....
  18. doi The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells
    Nadejda Valtcheva
    Interfakultäres Institut für Biochemie, Universitat Tubingen, 72076 Tubingen, Germany
    J Biol Chem 284:556-62. 2009
    ..The cGMP-dependent protein kinase type I (cGKI) is presumably a major mediator of cGMP effects, and the cGMP analogue Rp-8-Br-PET-cGMPS (Rp-PET) (chemical name: ..
  19. pmc Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice
    Eiki Takimoto
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Invest 119:408-20. 2009
    ..Thus, RGS2 is required for early myocardial compensation to pressure overload and mediates the initial antihypertrophic and cardioprotective effects of PDE5 inhibitors...
  20. pmc cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness
    Sonja Langmesser
    Division of Biochemistry, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    PLoS ONE 4:e4238. 2009
    ..and circadian rhythms, we analyzed these two processes in mice deficient for cGMP-dependent protein kinase type I (PRKG1) in the brain...
  21. pmc Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro- and antifibrotic signals in blood vessels
    Naoki Sawada
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Mol Cell Biol 29:6018-32. 2009
    ....
  22. doi Protein kinase G controls brown fat cell differentiation and mitochondrial biogenesis
    Bodo Haas
    Institute for Pharmacology and Toxicology, Biomedical Center, University of Bonn, Bonn, Germany
    Sci Signal 2:ra78. 2009
    ..Thus, PKGI links NO and cGMP signaling with the RhoA-ROCK and the insulin pathways, thereby controlling induction of adipogenic and thermogenic programs during brown fat cell differentiation...
  23. pmc Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes
    Robert Lukowski
    Forschergruppe 923 and Institut für Pharmakologie und Toxikologie, Technische Universitat Munchen, D 80802 Munich, Germany
    Proc Natl Acad Sci U S A 107:5646-51. 2010
    It has been suggested that cGMP kinase I (cGKI) dampens cardiac hypertrophy...
  24. pmc Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2
    Michael Klaiber
    Institute of Physiology, University of Wurzburg, Physiologisches Institut der Universität Würzburg, Germany
    Basic Res Cardiol 105:583-95. 2010
    ..Furthermore, they strengthen published observations in neonatal cardiomyocytes showing that TRPC3/TRPC6 channels are essential for Ang II, but not for beta-adrenergic Ca(2+) (i)-stimulation in adult myocytes...
  25. pmc Cyclic GMP kinase I modulates glucagon release from pancreatic α-cells
    Veronika Leiss
    Technische Universitat Munchen, Germany
    Diabetes 60:148-56. 2011
    ..We hypothesized that cGMP-dependent protein kinase type I (cGKI) is directly involved in the secretion of islet hormones and glucose homeostasis.
  26. pmc Increased adhesion and aggregation of platelets lacking cyclic guanosine 3',5'-monophosphate kinase I
    S Massberg
    Institut für Chirurgische Forschung der Ludwig Maximilians Universität München, 81377 Munchen, Germany
    J Exp Med 189:1255-64. 1999
    ..A major downstream target of NO is cyclic guanosine 3', 5'-monophosphate kinase I (cGKI)...
  27. ncbi Distribution of cGMP-dependent protein kinase type I and its isoforms in the mouse brain and retina
    S Feil
    Institut fur Pharmakologie und Toxikologie der Technischen Universitat Munchen, Biedersteiner Strasse 29, 80802 Munchen, Germany
    Neuroscience 135:863-8. 2005
    ..messenger cyclic guanosine-3',5'-monophosphate (cGMP) and activation of the cGMP-dependent protein kinase type I (cGKI)...
  28. ncbi Distribution of IRAG and cGKI-isoforms in murine tissues
    A Geiselhöringer
    Institut für Pharmakologie und Toxikologie der TU München, Biedersteiner Strasse 29, 80802 Munchen, Germany
    FEBS Lett 575:19-22. 2004
    cGMP kinase I (cGKI) signaling modulates multiple physiological processes including smooth muscle relaxation...
  29. pmc (D)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ialpha
    Christian K Nickl
    Department of Pharmacology, University of Vermont, College of Medicine, HSRF 330, 149 Beaumont Avenue, Burlington, VT 05405, USA
    Biochim Biophys Acta 1804:524-32. 2010
    ....
  30. pmc Sodium depletion enhances renal expression of (pro)renin receptor via cyclic GMP-protein kinase G signaling pathway
    Jiqian Huang
    Division of Endocrinology and Metabolism, University of Virginia Health System, Charlottesville, VA 22908 1409, USA
    Hypertension 59:317-23. 2012
    ..We conclude that sodium depletion upregulates renal PRR expression via the cGMP-PKG signaling pathway by enhancing binding of cAMP response element binding protein 1, nuclear factor-κB p65, and c-Jun to PRR promotor...
  31. pmc Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity
    Ceng Luo
    Pharmacology Institute, University of Heidelberg, Heidelberg, Germany
    PLoS Biol 10:e1001283. 2012
    ....
  32. doi cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells
    Keizo Yuasa
    Department of Biological Science and Technology, The University of Tokushima Graduate School, Tokushima 770 8506, Japan
    Biochem Biophys Res Commun 421:239-44. 2012
    ..Our findings suggest that cGK-Iα interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation...
  33. doi H₂O₂ lowers the cytosolic Ca²⁺ concentration via activation of cGMP-dependent protein kinase Iα
    Paul Markus Müller
    Interfakultäres Institut für Biochemie, University of Tubingen, 72076 Tubingen, Germany
    Free Radic Biol Med 53:1574-83. 2012
    The cGMP-dependent protein kinase I (cGKI) is a key mediator of cGMP signaling, but the specific functions of its two isoforms, cGKIα and cGKIβ, are poorly understood...
  34. doi Increased cGMP promotes healthy expansion and browning of white adipose tissue
    Michaela M Mitschke
    Institute of Pharmacology and Toxicology, University of Bonn, Bonn, Germany
    FASEB J 27:1621-30. 2013
    ..Taken together, PKGI is a key regulator of cell size, adipokine secretion and browning of white fat depots and thus could be a valuable target in developing novel treatments for obesity...
  35. doi Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity
    Sabine Klein
    Department of Internal Medicine 2, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen 81675, Germany
    Nat Commun 4:1630. 2013
    ..The results of our study show at the genetic level that these disorders are not only due to loss of slow-wave activity but also due to disturbed neurotransmission...
  36. pmc Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease
    Robert M Blanton
    Tufts Medical Center, Molecular Cardiology Research Institute, 800 Washington Street, Box 80, Boston, MA 02111
    J Gerontol A Biol Sci Med Sci 68:1351-5. 2013
    ..These findings reveal a role of PKGIα in normally attenuating hypertensive LVH. Therefore, mutation of the PKGIα LZ domain produces a clinically relevant model for hypertensive heart disease of aging. ..
  37. doi Thrombocytosis as a response to high interleukin-6 levels in cGMP-dependent protein kinase I mutant mice
    Lin Zhang
    Medizinische Klinik und Poliklinik I, Klinikum der Universitat, Ludwig Maximilians Universitat, Munich, Germany
    Arterioscler Thromb Vasc Biol 33:1820-8. 2013
    The purpose of this study was to investigate the influence of cGMP-dependent kinase I (cGKI) on platelet production.
  38. pmc The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone
    Florian Loga
    FOR 923, Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Str 29, 80802 Munich, Germany
    Cardiovasc Res 100:280-7. 2013
    Signalling via cGMP-dependent protein kinase I (cGKI) is the major pathway in vascular smooth muscle (SM), by which endothelial NO regulates vascular tone...
  39. doi Bifurcation of axons from cranial sensory neurons is disabled in the absence of Npr2-induced cGMP signaling
    Gohar Ter-Avetisyan
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    J Neurosci 34:737-47. 2014
    ..CNP), its receptor, the guanylyl cyclase natriuretic peptide receptor 2 (Npr2), and the cGMP-dependent kinase Iα (cGKIα) that regulates axon bifurcation of dorsal root ganglion (DRG) neurons in the spinal cord...
  40. pmc Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation
    Kinya Seo
    From the Division of Cardiology, Department of Medicine K S, P P R, D i L, S H, D B, O H C, D A K and Department of Biomedical Engineering D A K, The Johns Hopkins Medical Institutions, Baltimore, MD Division of Cardiology, Medical University of Graz, Graz, Austria P P R and National Institute of Environmental Health Science, Research Triangle Park, NC L B
    Circ Res 114:823-32. 2014
    ..The relevant mechanotransducers and therapies to target them remain unclear...
  41. pmc Increasing cGMP-dependent protein kinase activity attenuates unilateral ureteral obstruction-induced renal fibrosis
    Wenpeng Cui
    Graduate Center for Nutritional Sciences, Univ of Kentucky, Wethington Bldg, Rm 583, 900 S Limestone St, Lexington, KY 40536
    Am J Physiol Renal Physiol 306:F996-1007. 2014
    ..Taken together, these data suggest that increasing PKG activity ameliorates renal fibrosis in part through regulation of macrophage and tubular cell function, leading to reduced TGF-β-induced fibrosis...
  42. doi Expression of cGMP-dependent protein kinase type I in mature white adipocytes
    Veronika Leiss
    Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Tuebingen, Tuebingen, Germany FOR 923, Institute of Pharmacology and Toxicology, Technical University Munich, Muenchen, Germany
    Biochem Biophys Res Commun 452:151-6. 2014
    The presence of cGMP-dependent protein kinase I (cGKI) in murine adipocytes has been questioned, although cGKI was implicated in the thermogenic program of fat cells (FCs) and to exert anti-hypertrophic/-inflammatory effects in white ..
  43. pmc Nitrergic neuromuscular transmission in the mouse internal anal sphincter is accomplished by multiple pathways and postjunctional effector cells
    C A Cobine
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada
    Am J Physiol Gastrointest Liver Physiol 307:G1057-72. 2014
    ..Protein expression of guanylate cyclase (GCα, GCβ) and cyclic GMP-dependent protein kinase I (cGKI) were examined in cryostat sections with dual-labeling immunohistochemical techniques in PDGFRα(+) cells, ..
  44. pmc Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes
    Yasutoshi Ando
    From the Departments of Animal Sciences and Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    J Biol Chem 290:5881-92. 2015
    ..The present study describes analysis of the novel TNF-α-induced pathway, cGK-Iα-GKAP42, which regulates insulin-dependent signals and GLUT4 translocation. ..
  45. pmc Interaction of cCMP with the cGK, cAK and MAPK Kinases in Murine Tissues
    Stefanie Wolfertstetter
    Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Regensburg, Regensburg, Germany
    PLoS ONE 10:e0126057. 2015
    ..of cCMP on purified cyclic nucleotide-dependent protein kinases and lung and jejunum tissues of wild type (WT), cGKI-knockout (cGKI KO) and cGKII-knockout (cGKII KO) mice...
  46. ncbi IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
    Melanie Antl
    Institut fur Pharmakologie und Toxikologie der Technischen Universitat Munchen, Germany
    Blood 109:552-9. 2007
    ..activation/aggregation is nitric oxide (NO)/cyclic GMP (cGMP) signaling by cGMP-dependent protein kinase I (cGKI). However, the regulatory cascade downstream of cGKI mediating platelet inhibition is still unclear...
  47. doi Cyclic cytidine 3',5'-monophosphate (cCMP) signals via cGMP kinase I
    Matthias Desch
    Pharmacology and Toxicology, University Regensburg, Regensburg, Germany
    FEBS Lett 584:3979-84. 2010
    ..cCMP-induced relaxation was abolished in cGKI-knockout tissue...
  48. doi Kinetics of relaxation by cGMP/cGKI signaling in fundus smooth muscle
    Claudia Ertl
    FOR923, Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Germany
    Eur J Pharmacol 670:266-71. 2011
    cGMP-dependent kinase I (cGKI) is a major mediator of smooth muscle relaxation and exists in two isoforms, α and β. Both isoforms are supposed to mediate their effects via different intracellular signaling pathways...
  49. pmc A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide
    Michael Klaiber
    Institute of Physiology, Universitat Wurzburg, 97070 Wurzburg, Germany
    Proc Natl Acad Sci U S A 108:18500-5. 2011
    ..The concomitant rise in [Ca(2+)](i) might increase the propensity to cardiac hypertrophy and arrhythmias...
  50. pmc Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I
    Stefan Frantz
    Department of Internal Medicine I, University Hospital Wurzburg, Wurzburg, Germany
    Eur Heart J 34:1233-44. 2013
    ..It was suggested that cGMP-dependent protein kinase I (cGKI) mediates this protective effect, although the role in vivo is under debate...
  51. doi cGMP-dependent activation of protein kinase G precludes disulfide activation: implications for blood pressure control
    Joseph Robert Burgoyne
    Cardiovascular Division, King s College London, Rayne Institute, St Thomas Hospital, London SE1 7EH, United Kingdom
    Hypertension 60:1301-8. 2012
    ..Consequently, cGMP depletion sensitizes PKG to oxidation; this happens to a lesser extent in aortas than in mesenteries, because the conduit vessels generate more NO and express more peroxiredoxin...
  52. pmc Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport
    Shin Kato
    Cardiovascular Research Center of the General Medical Services, Massachusetts General Hospital, Boston, MA, USA
    Am J Physiol Lung Cell Mol Physiol 305:L130-40. 2013
    ..These data indicate for the first time that PCs have a role in regulating PKGI proteolysis and the nuclear localization of its active cleavage product, which are important for cGMP-mediated SMC phenotype. ..
  53. pmc Protein kinase G oxidation is a major cause of injury during sepsis
    Olena Rudyk
    Cardiovascular Division, King s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas Hospital, London SE1 7EH, United Kingdom
    Proc Natl Acad Sci U S A 110:9909-13. 2013
    ..We conclude that oxidative activation of PKG Iα is a key mediator of hypotension and consequential organ injury during sepsis...
  54. pmc Role of cGMP-kinase II in the control of renin secretion and renin expression
    C Wagner
    Institut fur Physiologie I, Universitat Regensburg, D 93040 Regensburg, Germany
    J Clin Invest 102:1576-82. 1998
    ..the cGMP-dependent protein kinases (cGKs) in the control of the renin system, we studied the regulation of renin in cGKI- or cGKII-deficient mice in vivo and in vitro...
  55. ncbi Cyclic GMP-dependent protein kinases: understanding in vivo functions by gene targeting
    P Ruth
    Institut für Pharmakologie und Toxikologie der Technischen Universität, Munchen, Germany
    Pharmacol Ther 82:355-72. 1999
    ..Mice deficient in cGMP kinases exhibit severe defects and, therefore, may serve as animal models for several human diseases, including hypertension, thrombosis, gastrointestinal dysmotility, and dwarfism...
  56. pmc Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice
    P Hedlund
    Department of Clinical Pharmacology, University of Lund, S 221 85 Lund, Sweden
    Proc Natl Acad Sci U S A 97:2349-54. 2000
    ..Herein, we report that mice lacking cGMP-dependent kinase I (cGKI) have a very low ability to reproduce and that their corpora cavernosa fail to relax on activation of the NO/cGMP ..
  57. ncbi The cGMP synthesis and PKG1 expression in murine lymphoid organs
    Ewa Kurowska
    Laboratory of Signaling Proteins, L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw
    Arch Immunol Ther Exp (Warsz) 50:289-94. 2002
    ..In spleen cells, however, cyclase GC-B appears to be the more active enzyme. Elevated cGMP concentration may in turn activate PKG1beta in thymus, lymph node, and spleen cells and also PKG1alpha in spleen cells...
  58. ncbi Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory
    Thomas Kleppisch
    Institut fur Pharmakologie und Toxikologie, 80802 Munchen, Germany, Max Planck Institut fur Psychiatrie, 80804 München, Germany
    J Neurosci 23:6005-12. 2003
    cGMP-dependent protein kinase I (cGKI) is expressed in the hippocampus, but its role in hippocampal long-term potentiation (LTP) is controversial. In addition, whether cGKI is involved in spatial learning has not been investigated...
  59. pmc Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I
    Robert Feil
    Institut fur Pharmakologie und Toxikologie, Technische Universitat, Biedersteiner Str 29, D 80802 München, Germany
    J Cell Biol 163:295-302. 2003
    ..Cerebellar Purkinje cells (PCs) contain a high concentration of cGMP-dependent protein kinase type I (cGKI)...
  60. ncbi Modulation of Ca2+ sensitivity by cyclic nucleotides in smooth muscle from protein kinase G-deficient mice
    Johan Bonnevier
    Department of Physiological Sciences, Martinsried, Munich 82152, Germany
    J Biol Chem 279:5146-51. 2004
    ..We have explored cGMP- and cAMP-dependent relaxation of smooth muscle using PKG-deficient mice (cGKI-/-)...
  61. ncbi Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6
    Bryan T MacDonald
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Development 131:2543-52. 2004
    ..These compensatory interactions between Dkk1 and Lrp6 demonstrate the importance of correctly balancing positive and negative regulation of Wnt signaling during mammalian development...
  62. ncbi A platelet secretion pathway mediated by cGMP-dependent protein kinase
    Zhenyu Li
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 279:42469-75. 2004
    ..These data unveil a novel PKG-dependent platelet secretion pathway and a mechanism by which PKG promotes platelet activation...
  63. pmc IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase
    Angela Geiselhöringer
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Strasse 29, 80802 Munchen, Germany
    EMBO J 23:4222-31. 2004
    Signalling by cGMP-dependent protein kinase type I (cGKI) relaxes various smooth muscles modulating thereby vascular tone and gastrointestinal motility...
  64. ncbi cGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo
    Michael Koeppen
    Physiologisches Institut, Universitat Lubeck, Germany
    Hypertension 44:952-5. 2004
    cGMP and cGMP-dependent protein kinase type I (cGKI) mediate the dilation of large vessels in response to NO and acetylcholine (ACh)...
  65. pmc FoxO1a-cyclic GMP-dependent kinase I interactions orchestrate myoblast fusion
    Philippe R J Bois
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell Biol 25:7645-56. 2005
    ..autoregulatory loop in which FoxO1a directly activates transcription of the cyclic GMP-dependent protein kinase I (cGKI) gene and where the ensuing cGKI activity phosphorylates FoxO1a and abolishes its DNA binding activity...
  66. ncbi Nitric oxide regulates prolidase activity by serine/threonine phosphorylation
    Arkadiusz Surazynski
    Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Cell Biochem 96:1086-94. 2005
    ....
  67. ncbi A sensitive method for determining the phosphorylation status of natriuretic peptide receptors: cGK-Ialpha does not regulate NPR-A
    Paula M Bryan
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota 55455, USA
    Biochemistry 45:1295-303. 2006
    ..Furthermore, we find that Pro-Q Diamond staining is a sensitive method for measuring the phosphate levels of natriuretic peptide receptors, but protein levels are best detected by Western blot analysis, not SYPRO Ruby staining...
  68. ncbi The cGMP/protein kinase G pathway contributes to dihydropyridine-sensitive calcium response and cytokine production in TH2 lymphocytes
    Bruno Gomes
    INSERM, 1U563, Centre de Physiopathologie de Toulouse Purpan, F 31024 Toulouse Cedex 3, France
    J Biol Chem 281:12421-7. 2006
    ..Altogether, our data indicate that, in Th2 cells, cGMP is produced upon TCR engagement and activates PKG, which controls DHP-sensitive calcium inflow and Th2 cytokine production...
  69. ncbi Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway
    Li Ma
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, School of Medicine, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 281:30990-1001. 2006
    ..Protein kinase G is shown to be a critical downstream effector of the noncanonical Wnt-Frizzled-2/cGMP/Ca2+ pathway...
  70. ncbi cGMP signals mainly through cAMP kinase in permeabilized murine aorta
    René Wörner
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Str 29, 80802 Munchen, Germany
    Am J Physiol Heart Circ Physiol 292:H237-44. 2007
    ..Ca(2+) desensitization is mediated probably by both cGMP- and cAMP-dependent protein kinases (cGKI and PKA). We investigate to which extent Ca(2+) desensitization is initiated by cGKI and PKA...
  71. doi Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain
    Achim Schmidtko
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, 60590 Frankfurt am Main, Germany
    J Neurosci 28:1320-30. 2008
    The cGMP/cGMP-dependent protein kinase I (cGKI) signaling pathway plays an important role in spinal nociceptive processing. However, downstream targets of cGKI in this context have not been identified to date...
  72. pmc Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis
    Robert Lukowski
    Institut für Pharmakologie und Toxikologie der TUM, Biedersteiner Str 29, D 80802 München, Germany
    Arterioscler Thromb Vasc Biol 28:1244-50. 2008
    ..Although cGMP-dependent protein kinase type I (cGKI) is a principal effector of NO, the molecular pathway of vascular NO signaling in restenosis is unclear...
  73. pmc Proteolytic processing of cGMP-dependent protein kinase I mediates nuclear cGMP signaling in vascular smooth muscle cells
    Takahiro Sugiura
    Cardiovascular Research Center, Departments of Anesthesia, Massachusetts General Hospital, Boston and Harvard Medical School, USA
    Circ Res 103:53-60. 2008
    ..These observations suggest that posttranslational modification of PKGI critically influences the nuclear translocation of PKGI and activities of cGMP in SMCs...
  74. pmc Cyclic guanosine monophosphate-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells
    Pascal Weinmeister
    Institut fur Pharmakologie und Toxikologie, Technischen Universiät München, D 80802 München, Germany
    Mol Biol Cell 19:4434-41. 2008
    The cyclic guanosine monophosphate (cGMP)/cGMP-dependent protein kinase type I (cGKI) pathway regulates many cellular functions...
  75. pmc Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta
    Anindita Das
    Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 283:29572-85. 2008
    ..Moreover, our results demonstrate that sildenafil activates a PKG-dependent novel signaling cascade that involves activation of ERK and inhibition of glycogen synthase kinase 3beta leading to cytoprotection...
  76. pmc Cyclic GMP specifically suppresses Type-Ialpha cGMP-dependent protein kinase expression by ubiquitination
    Nupur B Dey
    The Department of Physiology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Cell Signal 21:859-66. 2009
    ..The results suggest that chronic elevation of cGMP, as seen in inflammatory conditions, triggers ubiquitination and degradation of PKG-Ialpha in smooth muscle...
  77. pmc cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis
    Alexandra Aicher
    Department of Internal Medicine III, JW Goethe University, Frankfurt, Germany
    PLoS ONE 4:e4879. 2009
    ..Since several important effects of nitric oxide are mediated by cGMP-dependent pathways, we investigated the role of the cGMP downstream effector cGMP-dependent protein kinase I (cGKI) on postnatal neovascularization.
  78. doi Involvement of multiple protein kinases in cPLA2 phosphorylation, arachidonic acid release, and cell death in in vivo and in vitro models of 1-methyl-4-phenylpyridinium-induced parkinsonism--the possible key role of PKG
    Malgorzata Chalimoniuk
    Department of Cellular Signaling, Mossakowski Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
    J Neurochem 110:307-17. 2009
    ....
  79. doi Calcium-dependent and calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle
    Eva Frei
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 297:G834-9. 2009
    cGMP-dependent protein kinase I (cGKI) induces relaxation of smooth muscle via several pathways that include inhibition of intracellular Ca(2+) signaling and/or involve activation of myosin phosphatase...
  80. pmc Regulation of axonal development by natriuretic peptide hormones
    Zhen Zhao
    Zilkha Neurogenetic Institute, Department of Cell and Neurobiology, Keck School of Medicine, Neuroscience Graduate Program, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 106:18016-21. 2009
    ..Because their receptors are present in many regions of the embryonic and adult brain, we propose that these hormones have wide influence on the development and function of the nervous system...
  81. pmc Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition
    Norimichi Koitabashi
    Division of Cardiology, Ross 858, Department of Medicine, Johns Hopkins University Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Mol Cell Cardiol 48:713-24. 2010
    ..Thus PDE5-inhibition blocks TRPC6 channel activation and associated Cn/NFAT activation signaling by PKG-dependent channel phosphorylation...
  82. pmc Transforming growth factor-beta modulates the expression of nitric oxide signaling enzymes in the injured developing lung and in vascular smooth muscle cells
    Patricia R Bachiller
    Cardiovascular Research Center, Massachusetts General Hospital East, 149 13th St, Charlestown, MA 02129, USA
    Am J Physiol Lung Cell Mol Physiol 298:L324-34. 2010
    ..Moreover, they suggest that TGF-beta-neutralizing molecules might counteract the effects of injury on NO signaling in the newborn lung...
  83. pmc Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-{beta} activity in vascular smooth muscle cells
    Shuxia Wang
    Univ of Kentucky, Lexington, 40536, USA
    Am J Physiol Cell Physiol 298:C1188-97. 2010
    ..Together, these data establish that glucose-mediated downregulation of PKG levels stimulates TSP1 expression and enhances TGF-beta activity and matrix protein expression, which can contribute to vascular remodeling in diabetes...
  84. doi cGMP-dependent protein kinase type I promotes CREB/CRE-mediated gene expression in neurons of the lateral amygdala
    Cindy Paul
    Institut fur Pharmakologie und Toxikologie der Technischen Universitat Munchen, Biedersteiner Strasse 29, 80802 Munchen, Germany
    Neurosci Lett 473:82-6. 2010
    ..We have shown recently that the cGMP-dependent protein kinase Type I (cGKI) plays an important role for the consolidation of amygdala-dependent fear memory and long-term potentiation (LTP) ..
  85. pmc cGMP increases antioxidant function and attenuates oxidant cell death in mouse lung microvascular endothelial cells by a protein kinase G-dependent mechanism
    R Scott Stephens
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 299:L323-33. 2010
    ..We conclude that cGMP, through PKG(I), attenuated H(2)O(2)-induced cytotoxicity in MLMVEC by increasing catalase and Gpx-1 expression through an unknown posttranscriptional effect...
  86. doi Aromatic L-amino acid decarboxylase phosphorylation and activation by PKGIalpha in vitro
    Anne Marie Duchemin
    Division of Molecular Neuropsychopharmacology, Department of Psychiatry, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    J Neurochem 114:542-52. 2010
    ..Neuronal AAAD is best known for its role in the biosynthesis of catecholamines, indoleamines and trace amines in the nervous system, and the biological importance of PKGIalpha phosphorylation in these processes remains to be determined...
  87. doi Overexpression of constitutively active PKG-I protects female, but not male mice from diet-induced obesity
    Dejan M Nikolic
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA
    Obesity (Silver Spring) 19:784-91. 2011
    ..Together, these data demonstrate sex differences in effects of PKG-I activation on the regulation of adipose tissue function and its contribution to diet induced obesity...
  88. doi Essential roles of the nitric oxide (no)/cGMP/protein kinase G type-Iα (PKG-Iα) signaling pathway and the atrial natriuretic peptide (ANP)/cGMP/PKG-Iα autocrine loop in promoting proliferation and cell survival of OP9 bone marrow stromal cells
    Janica C Wong
    Cancer Molecular Biology Section, Nevada Cancer Institute, Las Vegas, Nevada 89135, USA
    J Cell Biochem 112:829-39. 2011
    ..The data suggest that basal NO/cGMP/PKG-Iα activity and autocrine ANP/cGMP/PKG-Iα are necessary for preserving OP9 cell survival and promoting cell proliferation and migration...
  89. pmc Genetic ablation of cGMP-dependent protein kinase type I causes liver inflammation and fasting hyperglycemia
    Stefan Z Lutz
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 60:1566-76. 2011
    The nitric oxide/cGMP/cGMP-dependent protein kinase type I (cGKI) signaling pathway regulates cell functions that play a pivotal role in the pathogenesis of type 2 diabetes...
  90. ncbi Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain
    M D Uhler
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0197
    J Biol Chem 268:13586-91. 1993
    ..The first class (CGKI) of amplification products contained approximately 1...
  91. ncbi Long-term potentiation in the hippocampal CA1 region of mice lacking cGMP-dependent kinases is normal and susceptible to inhibition of nitric oxide synthase
    T Kleppisch
    Institut fur Pharmakologie und Toxikologie, 80802 Munchen, Germany
    J Neurosci 19:48-55. 1999
    ..Two genes code for the isozymes cGKI and cGKII in vertebrates...
  92. ncbi Cyclic AMP- and cyclic GMP-dependent protein kinases differ in their regulation of cyclic AMP response element-dependent gene transcription
    S P Collins
    Department of Biological Chemistry and the Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 274:8391-404. 1999
    ....
  93. ncbi Functional characteristics of urinary tract smooth muscles in mice lacking cGMP protein kinase type I
    K Persson
    Department of Clinical Pharmacology, University of Lund, S 221 85 Lund, Sweden
    Am J Physiol Regul Integr Comp Physiol 279:R1112-20. 2000
    ..NO)-mediated smooth muscle relaxation is mediated by cGMP through activation of cGMP-dependent protein kinase I (cGKI)...
  94. ncbi Neutrophil dysfunction in guanosine 3',5'-cyclic monophosphate-dependent protein kinase I-deficient mice
    Claudia G Werner
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Munchen, Germany
    J Immunol 175:1919-29. 2005
    The regulation of neutrophil functions by Type I cGMP-dependent protein kinase (cGKI) was investigated in wild-type (WT) and cGKI-deficient (cGKI-/-) mice. We demonstrate that murine neutrophils expressed cGKIalpha...
  95. ncbi Inhibition of cGMP-dependent protein kinase reduces the response to sonic hedgehog in neuralized embryoid bodies
    Christin Christensen
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
    Stem Cells Dev 15:647-54. 2006
    ....
  96. ncbi A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase
    Tong Zhang
    Department of Medicine and Cancer Center, University of California, San Diego, California 92093 0652, USA
    J Biol Chem 282:33367-80. 2007
    ..Thus, CRP4 mediates cGMP/PKG stimulation of SM-specific gene expression, and PKG plays an important role in regulating the phenotype of VSMCs...
  97. ncbi Atrial natriuretic peptide inhibits transforming growth factor beta-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts
    Peng Li
    Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
    Circ Res 102:185-92. 2008
    ..We postulate that this process contributes to the antifibrogenic effects of the natriuretic peptide in heart...
  98. pmc The tumor suppressor p53 transcriptionally regulates cGKI expression during neuronal maturation and is required for cGMP-dependent growth cone collapse
    Andrea Tedeschi
    Center for Neurology, Laboratory for NeuroRegeneration and Repair, University of Tuebingen, D 72076 Tuebingen, Germany
    J Neurosci 29:15155-60. 2009
    The cGMP-dependent protein kinase type I (cGKI) has multiple functions including a role in axonal growth and pathfinding of sensory neurons, and counteracts Semaphorin 3A (Sema3A)-induced growth cone collapse...
  99. doi Protein kinase G dynamically modulates TASK1-mediated leak K+ currents in cholinergic neurons of the basal forebrain
    Hiroki Toyoda
    Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
    J Neurosci 30:5677-89. 2010
    ....
  100. pmc Impaired relaxation of stomach smooth muscle in mice lacking cyclic GMP-dependent protein kinase I
    L Ny
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    Br J Pharmacol 129:395-401. 2000
    1. Guanosine 3', 5'-cyclic monophosphate (cyclic GMP)-dependent kinase I (cGKI) is a major receptor for cyclic GMP in a variety of cells. Mice lacking cGKI exhibit multiple phenotypes, including severe defects in smooth muscle function...

Research Grants2

  1. REACTIVE OXYGEN SPECIES AND VASCULAR O2 SENSING
    Michael S Wolin; Fiscal Year: 2010
    ..These studies should help define the origins of differences in physiological responses of pulmonary and coronary arteries to changes in O2 tension. ..
  2. PULMONARY VASODILATION AND GUANYLATE CYCLASE REGULATION
    Michael S Wolin; Fiscal Year: 2010
    ....