Prox1

Summary

Gene Symbol: Prox1
Description: prospero homeobox 1
Alias: A230003G05Rik, prospero homeobox protein 1, PROX-1, homeobox prospero-like protein PROX1, prospero-related homeobox 1
Species: mouse

Top Publications

  1. pmc Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity
    Nicole C Johnson
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 22:3282-91. 2008
  2. ncbi Prox1 function is required for the development of the murine lymphatic system
    J T Wigle
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell 98:769-78. 1999
  3. pmc Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves
    R Sathish Srinivasan
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 25:2187-97. 2011
  4. doi Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation
    Amélie Sabine
    Division of Experimental Oncology, Multidisciplinary Oncology Center, University Hospital of Lausanne, Switzerland
    Dev Cell 22:430-45. 2012
  5. pmc Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades
    Koichi Mishima
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Mol Biol Cell 18:1421-9. 2007
  6. doi Neurogenin 2 has an essential role in development of the dentate gyrus
    Christophe Galichet
    Division of Molecular Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, UK
    Development 135:2031-41. 2008
  7. pmc Six3 activation of Pax6 expression is essential for mammalian lens induction and specification
    Wei Liu
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 25:5383-95. 2006
  8. ncbi The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration
    Sabrina Margagliotti
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Dev Biol 311:579-89. 2007
  9. doi Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels
    Emma J Gordon
    Division of Haematology, The Hanson Institute, Adelaide, South Australia, Australia
    Dev Dyn 237:1901-9. 2008
  10. pmc Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    R Ashery-Padan
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Goettingen D 37077, Germany
    Genes Dev 14:2701-11. 2000

Research Grants

  1. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
  2. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
  3. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
  4. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
  5. Afferent Innervation of the Postnatal Cochlea
    CLIFFORD HUME; Fiscal Year: 2008
  6. DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.
    Bernd Fritzsch; Fiscal Year: 2010
  7. FGF in sensory system development
    OLIVIA MARY BERMINGHAM MCDONOGH; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications138 found, 100 shown here

  1. pmc Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity
    Nicole C Johnson
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 22:3282-91. 2008
    The activity of the homeobox gene Prox1 is necessary and sufficient for venous blood endothelial cells (BECs) to acquire a lymphatic endothelial cell (LEC) fate...
  2. ncbi Prox1 function is required for the development of the murine lymphatic system
    J T Wigle
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell 98:769-78. 1999
    ..Here we report that the homeobox gene Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic ..
  3. pmc Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves
    R Sathish Srinivasan
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 25:2187-97. 2011
    ..We found that unlike LEC progenitors, which move out from the veins and differentiate into mature LECs, these Prox1-expressing ECs remain in the veins and do not acquire LEC features...
  4. doi Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation
    Amélie Sabine
    Division of Experimental Oncology, Multidisciplinary Oncology Center, University Hospital of Lausanne, Switzerland
    Dev Cell 22:430-45. 2012
    ..We found that the transcription factors PROX1 and FOXC2, highly expressed from the onset of valve formation, mediate segregation of lymphatic-valve-forming ..
  5. pmc Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades
    Koichi Mishima
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Mol Biol Cell 18:1421-9. 2007
    During embryonic lymphatic development, a homeobox transcription factor Prox1 plays important roles in sprouting and migration of a subpopulation of blood vessel endothelial cells (BECs) toward VEGF-C-expressing cells...
  6. doi Neurogenin 2 has an essential role in development of the dentate gyrus
    Christophe Galichet
    Division of Molecular Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, UK
    Development 135:2031-41. 2008
    ..These data establish a unique role of Ngn2 in DG neurogenesis during development and raise the possibility that Ngn2 has a similar function in adult neurogenesis...
  7. pmc Six3 activation of Pax6 expression is essential for mammalian lens induction and specification
    Wei Liu
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 25:5383-95. 2006
    ..We conclude that Six3 directly activates Pax6 and probably also Sox2 in the PLE and regulates cell autonomously the earliest stages of mammalian lens induction...
  8. ncbi The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration
    Sabrina Margagliotti
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Dev Biol 311:579-89. 2007
    ..This network operating at the onset of liver development contains candidate genes for investigation of liver carcinogenesis...
  9. doi Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels
    Emma J Gordon
    Division of Haematology, The Hanson Institute, Adelaide, South Australia, Australia
    Dev Dyn 237:1901-9. 2008
    ..Our data are also the first demonstration, to our knowledge, that the mouse yolk sac is devoid of lymphatic vessels...
  10. pmc Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    R Ashery-Padan
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Goettingen D 37077, Germany
    Genes Dev 14:2701-11. 2000
    ....
  11. pmc Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina
    Liang Feng
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Development 133:4815-25. 2006
    ..Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes...
  12. doi Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea
    Takayuki Okano
    Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland 20892, USA
    J Neurosci 31:18104-18. 2011
    ..The results also provide new insights regarding the pathological processes that underlie auditory defects in the absence of IGF signaling in both humans and mice...
  13. ncbi The chemokine SDF1 regulates migration of dentate granule cells
    Anil Bagri
    Neurodevelopmental Disorders Laboratory, Department of Neurology, Program in Neuroscience, University of California, San Francisco, CA 94143 0435, USA
    Development 129:4249-60. 2002
    ..Our study shows that a chemokine is necessary for the normal development of the dentate gyrus, a forebrain structure crucial for learning and memory...
  14. ncbi Prox 1, a prospero-related homeobox gene expressed during mouse development
    G Oliver
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Mech Dev 44:3-16. 1993
    b>Prox 1, a likely mouse homologue of the Drosophila homeobox gene prospero has been cloned and its expression pattern analyzed during development...
  15. pmc Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice
    Haotian Zhao
    Center for Human and Molecular Genetics, Columbus Children s Research Institute, Columbus, OH, USA
    Mol Vis 12:15-25. 2006
    ..These experiments were conducted to determine if Fgfr1 plays an independent, essential role in lens development...
  16. pmc Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation
    Amaya Miquelajauregui
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Proc Natl Acad Sci U S A 104:12919-24. 2007
    ..Sip1 is therefore essential to the development of the hippocampus and dentate gyrus, and is able to modulate Wnt signaling in these regions...
  17. pmc The role of hypoxia and neurogenic genes (Mash-1 and Prox-1) in the developmental programming and maturation of pulmonary neuroendocrine cells in fetal mouse lung
    Suzanne McGovern
    Division of Pathology, Department of Paediatric Laboratory Medicine, CIHR Group on Lung Development, The Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G1X8
    Lab Invest 90:180-95. 2010
    ..Thus, disturbances in intrauterine pO(2) homeostasis could alter the functional maturation of the PNEC system and hence be involved in the pathogenesis of various perinatal pulmonary disorders...
  18. pmc The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens
    Luke A Wiley
    Departments of Ophthalmology and Visual Sciences, Washington University, St Louis, MO, USA
    Invest Ophthalmol Vis Sci 51:3611-8. 2010
    ..to express epithelial cell markers, such as FoxE3 and E-cadherin, despite expressing the fiber cell marker Prox1. Many fiber cells lost their elongated morphology...
  19. ncbi Prox1 is differentially localized during lens development
    Melinda K Duncan
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Mech Dev 112:195-8. 2002
    b>Prox1, the vertebrate cognate of Drosophila Prospero, is a homeodomain protein essential for the development of the lens, liver and lymphatic system...
  20. pmc An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
    Jeffrey T Wigle
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 21:1505-13. 2002
    ..The homeobox gene Prox1 is expressed in a subpopulation of endothelial cells that, after budding from veins, gives rise to the mammalian ..
  21. ncbi Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina
    Michael A Dyer
    Department of Developmental Neurobiology, St Jude Children s Research Hospital Memphis, Tennessee 38105, USA
    Nat Genet 34:53-8. 2003
    ..We found that the homeodomain protein Prox1 regulates the exit of progenitor cells from the cell cycle in the embryonic mouse retina...
  22. ncbi Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities
    Cheng Ji Zhou
    Department of Neurology, Programs in Neuroscience and Developmental Biology, University of California, San Francisco, California 94143 0435, USA
    J Neurosci 24:121-6. 2004
    ....
  23. ncbi Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
    Tatiana V Petrova
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
    Nat Med 10:974-81. 2004
    ..Our results indicate that an abnormal interaction between the lymphatic endothelial cells and pericytes, as well as valve defects, underlie the pathogenesis of LD...
  24. ncbi Mesenchymal cells with leukocyte and lymphendothelial characteristics in murine embryos
    Kerstin Buttler
    Children s Hospital, Pediatrics I, University of Goettingen, Goettingen, Germany
    Dev Dyn 235:1554-62. 2006
    ..antibodies against the leukocyte marker CD45, the pan-endothelial marker CD31, and the lymphendothelial markers Prox1 and Lyve-1...
  25. ncbi Ptf1a determines horizontal and amacrine cell fates during mouse retinal development
    Yoshio Fujitani
    Vanderbilt University Program in Developmental Biology and Department of Cell and Developmental Biology, Vanderbilt University Medical School, Nashville, TN 37232 8240, USA
    Development 133:4439-50. 2006
    ..These data, together with the previous findings on Foxn4, provide a model in which the Foxn4-Ptf1a pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine cell fates...
  26. doi Prox1 regulates a transitory state for interneuron neurogenesis in the spinal cord
    Kamana Misra
    Robert Wood Johnson Medical School, UMDNJ, Piscataway, New Jersey 08854, USA
    Dev Dyn 237:393-402. 2008
    ..Here, we show that the Prox1 transcription factor, which is expressed transiently and specifically in spinal interneurons, plays an important ..
  27. pmc A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors
    Feng Qiu
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 28:3392-403. 2008
    ..Our data suggest that Brn3b specifies the RGC fate from multipotential precursors not only by promoting RGC differentiation but also by suppressing non-RGC differentiation programs as a safeguard mechanism...
  28. doi Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome
    Chantal F Medina
    Regenerative Medicine, Ottawa Health Research Institute, Ottawa, Ontario, Canada K1H 8L6
    Hum Mol Genet 18:966-77. 2009
    ..These results implicate a role for Atrx in interneuron survival and differentiation...
  29. ncbi Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system
    M a Torii
    Division of Neurobiology, The University of Tokyo Graduate School of Medicine, Bunkyo ku, Tokyo, 113 0033 Japan
    Development 126:443-56. 1999
    ..Thus, we propose that induction of Mash-1 and Prox-1 is one of the critical molecular events that control early development of the CNS...
  30. ncbi Prox1 function is crucial for mouse lens-fibre elongation
    J T Wigle
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Genet 21:318-22. 1999
    ..The expression pattern of the Prox1 homeobox gene suggests it has a role in a variety of embryonic tissues, including lens...
  31. ncbi Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1
    J Galceran
    Howard Hughes Medical Institute, Department of Microbiology, University of California, San Francisco, CA 94143, USA
    Development 127:469-82. 2000
    ..Thus, LEF1 regulates the generation of dentate gyrus granule cells, and together with other LEF1/TCF proteins, the development of the hippocampus...
  32. pmc Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy
    M Liu
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:865-70. 2000
    ..Furthermore, failure to express BETA2/NeuroD leads to a stereotyped pattern of pathological excitability of the adult central nervous system...
  33. ncbi Hepatocyte migration during liver development requires Prox1
    B Sosa-Pineda
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 25:254-5. 2000
    ..Here we report that Prox1 is required for hepatocyte migration...
  34. ncbi Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm
    Zoe Burke
    Department of Genetics, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Mech Dev 118:147-55. 2002
    ..We have also previously shown that the activity of the homeobox gene Prox1 controls hepatocyte migration during liver morphogenesis...
  35. pmc Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk
    Farhad Abtahian
    Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 299:247-51. 2003
    ..These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals...
  36. pmc T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema
    Vivien Schacht
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    EMBO J 22:3546-56. 2003
    ..lymphatic endothelium, and recent studies have shown that it is regulated by the lymphatic-specific homeobox gene Prox1. In this study, we examined the role of T1alpha/podoplanin in vascular development and the effects of gene ..
  37. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
    ..Our results indicate that VEGF-C is the paracrine factor essential for lymphangiogenesis, and show that both Vegfc alleles are required for normal lymphatic development...
  38. ncbi Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors
    Shengguo Li
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854 USA
    Neuron 43:795-807. 2004
    ..of amacrine and horizontal cells by activating the expression of the retinogenic factors Math3, NeuroD1, and Prox1. Our data suggest a model in which Foxn4 cooperates with other key retinogenic factors to mediate the multipotent ..
  39. ncbi Prox1 activity controls pancreas morphogenesis and participates in the production of "secondary transition" pancreatic endocrine cells
    Junfeng Wang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Dev Biol 286:182-94. 2005
    ..Here we show that the divergent homeodomain transcription factor Prox1 is a novel, crucial regulator of mouse pancreas organogenesis...
  40. ncbi Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
    Natasha L Harvey
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Nat Genet 37:1072-81. 2005
    ..We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels...
  41. pmc Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice
    Olga Medina-Martinez
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Biol 25:8854-63. 2005
    ..with changes in the expression of growth and differentiation factor genes, including DNase II-like acid DNase, Prox1, p57, and PDGFalpha receptor...
  42. pmc Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis
    Jay W Shin
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mol Biol Cell 17:576-84. 2006
    ..The homeodomain transcription factor Prox1 is essential for development of the lymphatic system by specifying lymphatic endothelial cell (LEC) fate...
  43. ncbi Characterization of a novel prospero-related homeobox gene, Prox2
    Ichiko Nishijima
    Center of Molecular and Human Genetics, Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
    Mol Genet Genomics 275:471-8. 2006
    ..Mouse Prox1 is essential for embryogenesis and is required to differentiate horizontal cells in the retina...
  44. pmc Expression of Prox1 during mouse cochlear development
    Olivia Bermingham-McDonogh
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Comp Neurol 496:172-86. 2006
    We carried out an analysis of the expression of Prox1, a homeo-domain transcription factor, during mouse inner ear development with particular emphasis on the auditory system...
  45. ncbi Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti
    Toshinori Hayashi
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology HNS, University of Washington, Seattle, Washington 98195, USA
    Dev Dyn 236:525-33. 2007
    ..Thus, in addition to controlling the fate decision between pillar cells and Deiters' cells, we find that Fgfr3 also regulates the width of the sensory epithelium...
  46. ncbi Prox1 expression patterns in the developing and adult murine brain
    Alfonso Lavado
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Dev Dyn 236:518-24. 2007
    b>Prox1, a homeobox gene related to the Drosophila gene prospero, is necessary for retina, lens, liver, pancreas, and lymphatics development. However, not much is yet known about Prox1 expression during central nervous system development...
  47. ncbi A prospero-related homeobox gene Prox-1 is expressed during postnatal brain development as well as in the adult rodent brain
    A Galeeva
    Department of Developmental Biology, Tampere University Medical School, Tampere, Finland
    Neuroscience 146:604-16. 2007
    ..The prominent but limited distribution of Prox-1 in the brain suggests its potentially important role during postnatal brain development and in adult CNS, which remains to be ascertained in future studies...
  48. ncbi A Gata2 intronic enhancer confers its pan-endothelia-specific regulation
    Melin Khandekar
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Development 134:1703-12. 2007
    ..Thus, GATA-2 is expressed early in lymphatic, cardiac and blood vascular endothelial cells, and the pan-endothelium-specific expression of Gata2 is controlled by a discrete intronic enhancer...
  49. pmc Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina
    Yasser Elshatory
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    J Comp Neurol 503:182-97. 2007
    ..Taken together, Isl1 is expressed during the maturation of and is later maintained in retinal ganglion cells and subtypes of amacrine and bipolar cells where it may function in the maintenance of these cells into adulthood...
  50. pmc Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature
    R Sathish Srinivasan
    Department of Genetics and Tumor Cell Biology, St Jude Children s Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 21:2422-32. 2007
    ..lineage-tracing studies using mouse strains expressing Cre recombinase under the control of the Tie2, Runx1, or Prox1 promoter elements...
  51. ncbi Lim1 is essential for the correct laminar positioning of retinal horizontal cells
    Ross A Poche
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:14099-107. 2007
    ..This study is the first to describe a cell type-specific genetic program that is essential for targeting a discrete retinal neuron population to the proper lamina...
  52. pmc Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea
    Toshinori Hayashi
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology HNS, Box 357923, USA
    Dev Biol 316:87-99. 2008
    ..This treatment also reduces Hesr1 and Hesr2 expression by as much as 80%. These results support the hypothesis that Hesr1 and Hesr2 are the downstream mediators of the prosensory function of Notch in early cochlear development...
  53. doi Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype
    Tatiana V Petrova
    Molecular and Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
    Cancer Cell 13:407-19. 2008
    ..factor Prospero functions as a tumor suppressor, and it has been suggested that the human counterpart of Prospero, PROX1, acts similarly in human cancers...
  54. pmc Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation
    Haotian Zhao
    Graduate Program in Molecular, Cellular and Developmental Biology, College of Biological Sciences, The Ohio State University, Columbus, OH 43210, USA
    Dev Biol 318:276-88. 2008
    ..of the cell cycle inhibitors p27(kip1) and p57(kip2), increased apoptosis and aberrant or reduced expression of Prox1, Pax6, c-Maf, E-cadherin and alpha-, beta- and gamma-crystallins...
  55. doi Expression of the basal cell markers of taste buds in the anterior tongue and soft palate of the mouse embryo
    Ayumi Nakayama
    Oral Physiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8544, Japan
    J Comp Neurol 509:211-24. 2008
    ..To examine the embryonic development of the basal cells, the expression of Shh, Prox1, and Mash1 was determined in the anterior tongue and soft palate in mouse embryos by in situ hybridization...
  56. doi Differential 24 h responsiveness of Prox1-expressing precursor cells in adult hippocampal neurogenesis to physical activity, environmental enrichment, and kainic acid-induced seizures
    B Steiner
    Max Delbrück Center for Molecular Medicine Berlin Buch, Research Group Neuronal Stem Cells, Robert Rossle Str 10, Berlin, Germany
    Neuroscience 154:521-9. 2008
    ..we here used the first expression of granule cell-specific transcription factor prospero-related homeobox 1 (Prox1) to identify lineage-determined progenitor cells in a nestin-green fluorescent protein (GFP) reporter gene mouse ..
  57. pmc Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice
    Michael Dellinger
    Department of Molecular and Cellular Biology, The University of Arizona, Tucson, AZ, USA
    Dev Biol 319:309-20. 2008
    ..Taken together, this work pinpoints a specific lymphatic defect of Ang2(-/-) mice and further defines the sequential steps in lymphatic vessel remodeling...
  58. doi Prox-1 promotes invasion of kaposiform hemangioendotheliomas
    Soheil S Dadras
    Department of Dermatology, Cutaneous Biology Research Center, Boston, Massachusetts, USA
    J Invest Dermatol 128:2798-806. 2008
    ..and vascular endothelial growth factor receptor-3, which is mediated by upregulation of the transcription factor Prox1. However, the potential effects of Prox1 expression on the biology of KS and, in particular, on the aggressive and ..
  59. doi Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia
    Anna Kirjavainen
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 322:33-45. 2008
    ..Here, we studied the role of the homeodomain transcription factor Prox1 in the inner ear sensory epithelia...
  60. pmc Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate
    Sunju Lee
    Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Blood 113:1856-9. 2009
    ..Homeodomain transcription factor Prox1 functions to reprogram venous ECs to lymphatic endothelial cells (LECs)...
  61. pmc Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice
    Jianxin Fu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Clin Invest 118:3725-37. 2008
    ..Our studies therefore demonstrate that EC O-glycans control the separation of blood and lymphatic vessels during embryonic and postnatal development, in part by regulating podoplanin expression...
  62. doi Sox18 induces development of the lymphatic vasculature in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 456:643-7. 2008
    ..from endothelial precursor cells budding from the cardinal vein under the influence of the lymphatic hallmark gene Prox1 (prospero homeobox 1; ref. 4)...
  63. pmc Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea
    Alain Dabdoub
    Section on Developmental Neuroscience, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:18396-401. 2008
    ..Sox2 expression is promoted by Notch signaling and Prox1, a homeobox transcription factor, is a downstream target of Sox2...
  64. doi Specific glial populations regulate hippocampal morphogenesis
    Guy Barry
    The University of Queensland, Queensland Brain Institute, and School of Biomedical Sciences, Brisbane, 4067, Australia
    J Neurosci 28:12328-40. 2008
    ..These data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis...
  65. pmc Prox1 maintains muscle structure and growth in the developing heart
    Catherine A Risebro
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Development 136:495-505. 2009
    ..We show that cardiac-specific inactivation of the murine homeobox transcription factor Prox1 results in the disruption of expression and localisation of sarcomeric proteins, gross myofibril disarray and ..
  66. pmc Pitx3 controls multiple aspects of lens development
    Olga Medina-Martinez
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Dyn 238:2193-201. 2009
    ..In general, our study shows that the abnormal phenotype of the ak lenses is not due to just one molecular pathway, rather in the absence of Pitx3 expression multiple aspects of lens development are disrupted...
  67. pmc Pax6 is essential for lens fiber cell differentiation
    Ohad Shaham
    Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Development 136:2567-78. 2009
    ..This study reveals that Pax6 is pivotal for initiation of the lens fiber differentiation program in the mammalian eye...
  68. doi Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation
    Pavel Uhrin
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Blood 115:3997-4005. 2010
    ..Therefore, interaction of endothelial podoplanin of the developing lymph sac with circulating platelets from the cardinal vein is critical for separating the lymphatic from the blood vascular system...
  69. pmc The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functions
    Alexis Charest-Marcotte
    Goodman Cancer Centre, McGill University, Montreal, Quebec, Canada
    Genes Dev 24:537-42. 2010
    ..Here we identified the homeobox protein prospero-related homeobox 1 (Prox1) as one such factor...
  70. doi Regulation of developmental lymphangiogenesis by Syk(+) leukocytes
    Ruben Böhmer
    Department of Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D 48149 Munster, Germany
    Dev Cell 18:437-49. 2010
    ..This mechanism does not involve circulating endothelial progenitor cells and demonstrates the potential of hematopoietic cells to control developmental lymphangiogenesis...
  71. pmc Netrin-4 induces lymphangiogenesis in vivo
    Frederic Larrieu-Lahargue
    Program in Molecular Medicine, Department of Medicine, University of Utah, Salt Lake City, UT, USA
    Blood 115:5418-26. 2010
    ..Together, these data provide evidence that Netrin-4 is a lymphangiogenic factor contributing to tumor dissemination and represents a potential target to inhibit metastasis formation...
  72. pmc Neurod1 regulates survival and formation of connections in mouse ear and brain
    Israt Jahan
    Department of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA 52242, USA
    Cell Tissue Res 341:95-110. 2010
    ....
  73. pmc Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature
    Harold Kim
    Sunnybrook Research Institute University of Toronto 2075 Bayview Avenue Toronto, Ontario M4N 3M5, Canada
    BMC Dev Biol 10:72. 2010
    In vivo studies demonstrate that the Prox1 transcription factor plays a critical role in the development of the early lymphatic system...
  74. pmc Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis
    Alfonso Lavado
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Biol 8:. 2010
    ..The homeobox gene Prox1 is expressed in the dentate gyrus during embryonic development and adult neurogenesis...
  75. pmc Prox1 regulates the notch1-mediated inhibition of neurogenesis
    Valeria Kaltezioti
    Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    PLoS Biol 8:e1000565. 2010
    ..Here, we provide evidence that Prox1, a transcription repressor and downstream target of proneural genes, counteracts Notch1 signaling via direct ..
  76. doi Sox1 maintains the undifferentiated state of cortical neural progenitor cells via the suppression of Prox1-mediated cell cycle exit and neurogenesis
    Maximilianos Elkouris
    Stem Cell Biology Laboratory, Institute of Molecular Biology and Genetics, Vari Attica, Greece
    Stem Cells 29:89-98. 2011
    ..In proliferating NP cells, Sox1 acts via a prospero-related homeobox 1 (Prox1)-mediated pathway to block cell cycle exit that leads to neuronal differentiation in vivo and in vitro...
  77. doi Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development
    Tomoko Tateya
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Dev Biol 352:329-40. 2011
    ....
  78. doi Rbpj regulates development of prosensory cells in the mammalian inner ear
    Norio Yamamoto
    Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, NIDCD, NIH, Bethesda, MD 20892, USA
    Dev Biol 353:367-79. 2011
    ..These results suggest important roles for Rbpj and notch signaling in multiple aspects of inner ear development including prosensory cell maturation, cellular differentiation and survival...
  79. pmc Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis
    Ozlem Karalay
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 108:5807-12. 2011
    ..Here we identified the prospero-related homeodomain transcription factor Prox1 as a target of β-catenin-TCF/LEF signaling in vitro and in vivo...
  80. pmc Mutations in the RNA granule component TDRD7 cause cataract and glaucoma
    Salil A Lachke
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 331:1571-6. 2011
    ..These findings demonstrate a role for RGs in vertebrate organogenesis...
  81. doi CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo
    Frank L Bos
    Hubrecht Institute KNAW, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Circ Res 109:486-91. 2011
    ..Insight into the molecular role of CCBE1 is completely lacking, and mouse models for the disease do not exist...
  82. pmc Mechanoinduction of lymph vessel expansion
    Lara Planas-Paz
    Institute of Metabolic Physiology, Heinrich Heine University, Dusseldorf, Germany
    EMBO J 31:788-804. 2012
    ..Thus, we propose a new and physiologically relevant mode of VEGFR3 activation, which is based on mechanotransduction and is essential for normal development and fluid homeostasis in a mammalian embryo...
  83. doi Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Dev Biol 364:89-98. 2012
    ..First, we define territories or "pre-lymphatic clusters" of Prox1-positive lymphatic endothelial progenitor cells along the antero-posterior axis of the cardinal veins...
  84. pmc Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal
    Sung Ho Huh
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 10:e1001231. 2012
    ..The viability and hearing loss in Fgf20 knockout mice suggest that FGF20 may also be a deafness-associated gene in humans...
  85. pmc Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression
    Zhiyong Liu
    Departments of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Neurosci 32:6600-10. 2012
    ..Therefore, combined expression of Atoh1 with additional factors holds therapeutic promise to convert PCs and DCs into functional HCs in vivo for regenerative purposes...
  86. doi Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3
    Catherine A Risebro
    Institute of Child Health, University College London, UK
    Circ Res 111:e19-31. 2012
    ..5 in the mouse phenocopies human conduction disease pathology yet the phenotypes, described in both mouse and man, are highly pleiotropic, implicit of unknown modifiers and/or factors acting in epistasis with Nkx2.5/NKX2.5...
  87. doi Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus
    Tomohiko Iwano
    Laboratory for Cell Asymmetry, at RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuou ku, Kobe 650 0047, Japan
    Development 139:3051-62. 2012
    ..Here, we demonstrate in mice that Prox1, a transcription factor constitutively expressed in the granule cell lineage, postmitotically functions to specify ..
  88. pmc Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos
    Ying Yang
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 120:2340-8. 2012
    ..process leading to the formation of the mammalian lymphatic vasculature starts by the expression of the gene Prox1 in a subpopulation of blood endothelial cells (BECs) on the cardinal vein (CV) at approximately E9.5...
  89. pmc The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis
    Zhiying Zou
    Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 121:3228-36. 2013
    ..Our findings reveal that CCBE1 plays an essential role in regulating the fetal liver erythropoietic environment and suggest that EBI formation is regulated differently in the fetal liver and bone marrow...
  90. ncbi Regulation of mouse lens fiber cell development and differentiation by the Maf gene
    B Z Ring
    Department of Pediatrics, Howard Hughes Medical Institute, Stanford, California 94305 5428, USA
    Development 127:307-17. 2000
    ..This phenotype partially overlaps with those reported for gene targeting of Prox1 and Sox1; however, expression of these genes is grossly normal, as is expression of Eya1, Eya2, Pax6, and Sox2...
  91. ncbi Sox gene expression during neuronal development
    M Rex
    Department of Craniofacial Development, UMDS, Guy s Hospital, London, UK
    Biochem Soc Trans 22:252S. 1994
  92. ncbi Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development
    Yi Pan
    Department of Medical and Molecular Genetics, Indiana University of Medicine, Indianapolis, IN 46202, USA
    Development 133:4933-44. 2006
    ..Taken together, these results establish an important role of Ndst1 function in FGF signaling during lens development...
  93. ncbi GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: correlation with Dlx2 and Dlx5
    Andrea Kwakowsky
    Department of Gene Technology and Developmental Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Dev Dyn 236:3532-44. 2007
    ..GABA and GAD are most abundant at the tips of elongating fibers and are absent from organelle-free cells, suggesting their involvement is primarily in shaping of the cytoskeleton during fiber elongation stages...
  94. pmc Adrenomedullin signaling is necessary for murine lymphatic vascular development
    Kimberly L Fritz-Six
    Department of Cell and Molecular Physiology, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 118:40-50. 2008
    ..endothelial cells, likely due to induction of CALCRL gene expression by the lymphatic transcriptional regulator Prox1. Collectively, our studies identify a class of genes involved in lymphangiogenesis that represent a ..
  95. pmc Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development
    Yan Li
    Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Dyn 238:2388-400. 2009
    ..5 and E14.5 but decreased as the lens degenerated. Our data indicated an indispensible role for Dicer and miRNAs in lens and corneal development...
  96. pmc Lens induction requires attenuation of ERK signaling by Nf1
    Christian Carbe
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Mol Genet 20:1315-23. 2011
    ..As a member of NCFC family genes, Nf1 represents the first example that attenuation of Ras-MAPK kinase signaling pathway is essential for normal lens development...
  97. ncbi Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections
    H J Cheng
    Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143 0452, USA
    Neuron 32:249-63. 2001
    ..Analysis of plexin-A3 knockout mice shows that plexin-A3 contributes to Sema3F and Sema3A signaling and that plexin-A3 regulates the development of hippocampal axonal projections in vivo...
  98. pmc Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype
    Guy Goudreau
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 99:8719-24. 2002
    ..Our findings thus provide a mechanism implicating gene regulatory interactions between Pax6 and Six3 in the tissue-specific defects found in Pax6 heterozygous mice...
  99. ncbi [Expression of regulatory genes Oct-4, Pax-6, Prox-1, Ptx-2 at the initial stages of differentiation of embryonic stem cells in vitro]
    O F Gordeeva
    Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, ul Vavilova 26, Moscow, 119991 Russia
    Ontogenez 34:174-82. 2003
    ..A probable role of these genes in differentiation of the murine embryonic stem cells is discussed...
  100. ncbi Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a
    Hideyuki Yoshitomi
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Development 131:807-17. 2004
    ..Additionally, we find that endothelial cells are necessary for the induction of both the insulin and glucagon genes...
  101. ncbi Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
    Roque Bort
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Aveue, Philadelphia, PA 19111, USA
    Development 131:797-806. 2004
    ..Other endodermal transcription factors may also function morphogenetically rather than by directly regulating tissue-specific programs...

Research Grants8

  1. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  2. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  3. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  4. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  5. Afferent Innervation of the Postnatal Cochlea
    CLIFFORD HUME; Fiscal Year: 2008
    ..Finally, I will use molecular techniques to begin to dissect the signals that regulate axon guidance in the developing auditory system. ..
  6. DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.
    Bernd Fritzsch; Fiscal Year: 2010
    ..Such information is crucial to govern the use of neurotrophins for regeneration, plasticity and maintenance of adult innervation. ..
  7. FGF in sensory system development
    OLIVIA MARY BERMINGHAM MCDONOGH; Fiscal Year: 2010
    ..Aim 2. Determine whether Hesr1 and Hesr2 are the downstream effectors of Jagged1/Notch. Aim 3. Determine whether Prox1 directly regulates expression of Fgfr3 in support cells of the developing organ of Corti? We will use a ..