Ptch1

Summary

Gene Symbol: Ptch1
Description: patched 1
Alias: A230106A15Rik, Ptc, Ptc1, Ptch, mes, protein patched homolog 1, Ptch1 protein +12b, mesenchymal dysplasia, patched homolog 1
Species: mouse

Top Publications

  1. ncbi Sonic hedgehog regulates growth and morphogenesis of the tooth
    H R Dassule
    Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
    Development 127:4775-85. 2000
  2. ncbi Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
    R J Wechsler-Reya
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA
    Neuron 22:103-14. 1999
  3. ncbi Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Cell 118:517-28. 2004
  4. pmc THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
    Pamela V Tran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 40:403-10. 2008
  5. pmc Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    B St-Jacques
    Harvard University, Department of Molecular and Cellular Biology, Cambridge, Massachusetts 02138 USA
    Genes Dev 13:2072-86. 1999
  6. ncbi The graded response to Sonic Hedgehog depends on cilia architecture
    Tamara Caspary
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 12:767-78. 2007
  7. ncbi Intraflagellar transport is essential for endochondral bone formation
    Courtney J Haycraft
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Development 134:307-16. 2007
  8. doi The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development
    Setsu Endoh-Yamagami
    Department of Molecular Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Curr Biol 19:1320-6. 2009
  9. ncbi Altered neural cell fates and medulloblastoma in mouse patched mutants
    L V Goodrich
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5427, USA
    Science 277:1109-13. 1997
  10. ncbi Ftm is a novel basal body protein of cilia involved in Shh signalling
    Jeanette Vierkotten
    Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Development 134:2569-77. 2007

Research Grants

  1. TG737 SIGNALING PATHWAY AND POLYCYSTIC KIDNEY
    Bradley Yoder; Fiscal Year: 2003
  2. Cilial dysfunction and pathogenesis of obesity
    Bradley K Yoder; Fiscal Year: 2010
  3. Conserved Mechanisms of Ciliogenesis
    Bradley Yoder; Fiscal Year: 2007
  4. GENETICS OF A TRANSGENIC MOUSE MODEL FOR NEUROBLASTOMA
    William Weiss; Fiscal Year: 2004
  5. Hedgehog Pathway in Urogenital Sinus Development
    David Berman; Fiscal Year: 2005
  6. Imaging Kinase Activity In Vivo
    William Weiss; Fiscal Year: 2006
  7. Eda/Edar Regulation of Embryonic SMG Development
    Tina Jaskoll; Fiscal Year: 2007
  8. Small RNAs in skeletogenesis
    Tatsuya Kobayashi; Fiscal Year: 2008
  9. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2008
  10. Hedgehog signaling links bladder injury and cancer
    DAVID MONTY BERMAN; Fiscal Year: 2010

Detail Information

Publications218 found, 100 shown here

  1. ncbi Sonic hedgehog regulates growth and morphogenesis of the tooth
    H R Dassule
    Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
    Development 127:4775-85. 2000
    ..These studies demonstrate that Shh regulates growth and determines the shape of the tooth. However, Shh signaling is not essential for differentiation of ameloblasts or odontoblasts...
  2. ncbi Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
    R J Wechsler-Reya
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA
    Neuron 22:103-14. 1999
    ..Blocking Shh function in vivo dramatically reduces GCP proliferation. These findings provide insight into the mechanisms of normal growth and tumorigenesis in the cerebellum...
  3. ncbi Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Cell 118:517-28. 2004
    ..Genetic studies of the effects of limiting accessibility of Shh within the limb support this model, in which the effect of the Shh morphogen is dictated by a temporal as well as a spatial gradient...
  4. pmc THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
    Pamela V Tran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 40:403-10. 2008
    ..Specifically, the aln mutation uncouples the roles of anterograde and retrograde transport in SHH signaling, suggesting that anterograde IFT is required for GLI activation and that retrograde IFT modulates this event...
  5. pmc Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    B St-Jacques
    Harvard University, Department of Molecular and Cellular Biology, Cambridge, Massachusetts 02138 USA
    Genes Dev 13:2072-86. 1999
    ..Together, the results suggest a model in which Ihh coordinates diverse aspects of skeletal morphogenesis through PTHrP-dependent and independent processes...
  6. ncbi The graded response to Sonic Hedgehog depends on cilia architecture
    Tamara Caspary
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 12:767-78. 2007
    ..Thus, normal structure of the ciliary axoneme is required for the cell to translate different levels of Shh ligand into differential regulation of the Gli transcription factors that implement Hedgehog signals...
  7. ncbi Intraflagellar transport is essential for endochondral bone formation
    Courtney J Haycraft
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Development 134:307-16. 2007
    ..Overall these data provide evidence that IFT is essential for normal formation of the appendicular skeleton through disruption of multiple signaling pathways...
  8. doi The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development
    Setsu Endoh-Yamagami
    Department of Molecular Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Curr Biol 19:1320-6. 2009
    ..These results suggest a role for Kif7 in coordinating Hh signal transduction at the tip of cilia and preventing Gli3 cleavage into a repressor form in the presence of Hh...
  9. ncbi Altered neural cell fates and medulloblastoma in mouse patched mutants
    L V Goodrich
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5427, USA
    Science 277:1109-13. 1997
    The PATCHED (PTC) gene encodes a Sonic hedgehog (Shh) receptor and a tumor suppressor protein that is defective in basal cell nevus syndrome (BCNS). Functions of PTC were investigated by inactivating the mouse gene...
  10. ncbi Ftm is a novel basal body protein of cilia involved in Shh signalling
    Jeanette Vierkotten
    Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Development 134:2569-77. 2007
    ..Furthermore, the absence of Ftm in arthropods underlines the divergence between vertebrate and Drosophila Hh pathways...
  11. ncbi Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    M P Matise
    Developmental Genetics Program and Howard Hughes Medical Institute, and Department of Cell Biology and Physiology and Neuroscience, NYU Medical Center, New York, NY 10016, USA
    Development 125:2759-70. 1998
    ....
  12. ncbi Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
    P M Lewis
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Cell 105:599-612. 2001
    ..Thus, cholesterol modification is essential for the normal range of signaling. It also appears to be necessary for appropriate modulation of signaling by the Shh receptor, Ptc1.
  13. pmc Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth
    Yu Lan
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 136:1387-96. 2009
    ....
  14. ncbi Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
    Q Ding
    Program in Developmental Biology and Division of Endocrinology, Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 125:2533-43. 1998
    ..We report that the expression of known Shh-responsive genes such as Ptc and Gli1 is downregulated in mutant mice lacking Gli2 function...
  15. ncbi Hedgehog signals regulate multiple aspects of gastrointestinal development
    M Ramalho-Santos
    Department of Molecular and Cellular Biology, and Howard Hughes Medical Institute, Harvard University, Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Development 127:2763-72. 2000
    ..These results show that Hedgehog signals are essential for organogenesis of the mammalian gastrointestinal tract and suggest that mutations in members of this signaling pathway may be involved in human gastrointestinal malformations...
  16. ncbi Hedgehog signaling is required for pituitary gland development
    M Treier
    Howard Hughes Medical Institute, School and Department of Medicine, UCSD, CMMW, Room 345, La Jolla, CA 92093 0648, USA
    Development 128:377-86. 2001
    ..Thus, SHH appears to exert effects on both proliferation and cell-type determination in pituitary gland development...
  17. ncbi Medulloblastoma growth inhibition by hedgehog pathway blockade
    David M Berman
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 297:1559-61. 2002
    ....
  18. doi Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation
    Nicholas Warr
    Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 17:2986-96. 2008
    ..The analysis provides genetic evidence that Zic2 functions during organizer formation and that the PCP develops via a multi-step process...
  19. pmc GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells
    Jason E Cain
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Towers, Toronto, Ontario, Canada
    PLoS ONE 4:e7313. 2009
    ..During renal morphogenesis, HH signaling activity, assayed by expression of Ptc1-lacZ, is localized to ureteric cells of the medulla, but is undetectable in the cortex...
  20. pmc Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome
    Cheng Cui
    University of Pittsburgh, Department of Developmental Biology, 8111 Rangos Research Center, 530 45th Street, Pittsburgh, PA 15201, USA
    Dis Model Mech 4:43-56. 2011
    ..On the basis of these results, we hypothesize a role for the B9 domain in mother centriole targeting, a possibility that warrants further future investigations...
  21. doi Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling
    Kelly Lenton
    Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Stanford University, Stanford, California 94028, USA
    Genesis 49:784-96. 2011
    ..In conjunction with the newly recognized roles of Hedgehog deregulation in craniosynostosis, our study defines Ihh as an important positive regulator of cranial bone ossification...
  22. pmc The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatus
    Congxing Lin
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 356:40-50. 2011
    ..We provide genetic evidence that disruption of either signaling pathway results in severe microglossia. Altogether, we demonstrate a dynamic role for Wnt-β-Catenin signaling in the development of the oral apparatus...
  23. pmc Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation
    Nicolas F Berbari
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Dev Biol 360:66-76. 2011
    ....
  24. pmc Cilia and Hedgehog responsiveness in the mouse
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:11325-30. 2005
    ....
  25. pmc Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart
    Matthew M Goddeeris
    Department of Cell Biology, Duke University Medical Center, Durham, NC, USA
    Development 135:1887-95. 2008
    ..Failure of this addition results in severe AVSD. These studies demonstrate that AVSD can result from a primary defect in dorsal mesocardium, providing a new paradigm for the understanding of human AVSD...
  26. pmc Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency
    Pierre Olivier Frappart
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:1880-5. 2009
    ..showed recurring chromosome 13 alterations via chromosomal loss or translocations involving regions containing Ptch1. Sequence analysis of the remaining Ptch1 allele showed a variety of inactivating mutations in all tumors analyzed,..
  27. ncbi The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    D M Stone
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 384:129-34. 1996
    ..We show that Ptc can form a physical complex with a newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), ..
  28. pmc Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4
    Salvatore Cortellino
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Dev Biol 325:225-37. 2009
    ..We conclude that complex A and complex B factors play similar but distinct roles in ciliogenesis and Shh/Gli3 signaling...
  29. ncbi Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia
    Ricardo C Moraes
    Baylor Breast Center and Department of Molecular and Cellular Biology, Room N1210 MS BCM600, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 134:1231-42. 2007
    ..We demonstrated previously that heterozygous disruption of the gene encoding the patched-1 (PTCH1) hedgehog receptor, a negative regulator of smoothened (Smo) in the absence of ligand, led to mammary ductal ..
  30. ncbi beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13092, Berlin, Germany
    Cell 105:533-45. 2001
    ..Further analysis demonstrates that beta-catenin is essential for fate decisions of skin stem cells: in the absence of beta-catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate...
  31. ncbi Loss of the Tg737 protein results in skeletal patterning defects
    Qihong Zhang
    The University of Alabama at Birmingham, Department of Cell Biology, Birmingham, Alabama 35294, USA
    Dev Dyn 227:78-90. 2003
    ..Collectively, the data argue for a dosage effect of Tg737 on the limb phenotypes and that the polydactyly is independent of Shh misexpression...
  32. ncbi Combined activities of hedgehog signaling inhibitors regulate pancreas development
    Hiroshi Kawahira
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 130:4871-9. 2003
    ..We have analyzed the function of two hedgehog inhibitors, Hhip and patched 1 (Ptch), during pancreas formation...
  33. ncbi Loss of suppressor-of-fused function promotes tumorigenesis
    Y Lee
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38405, USA
    Oncogene 26:6442-7. 2007
    ..resulted in early embryonic lethality in the mouse similar to inactivation of another SHH regulator, Patched1 (Ptch1). In contrast to Ptch1+/- mice, Sufu+/- mice were not tumor prone...
  34. ncbi Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    H Hahn
    Centre for Molecular and Cell Biology, University of Queensland, St Lucia, Australia
    Cell 85:841-51. 1996
    ..A human sequence (PTC) with strong homology to the Drosophila segment polarity gene, patched, was isolated from a YAC and cosmid contig ..
  35. ncbi Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo
    M A Dyer
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 128:1717-30. 2001
    ..To our knowledge, these are the earliest functions for a hedgehog protein in post-implantation development in the mouse embryo...
  36. ncbi Sonic hedgehog is required for cardiac outflow tract and neural crest cell development
    I Washington Smoak
    North Carolina State University, Raleigh, 27695, USA
    Dev Biol 283:357-72. 2005
    ..Our data suggest that SHH signaling does not act directly on NCCs as a survival factor, but rather acts to restrict the domains that NCCs can populate during early stages (e8.5-10.5) of cardiovascular and craniofacial development...
  37. doi Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice
    Ines Ecke
    Institute of Human Genetics, University of Goettingen, Gottingen, Germany
    Cancer Res 69:887-95. 2009
    Patched (Ptch) heterozygous mice develop medulloblastoma (MB) and rhabdomyosarcoma (RMS) resembling the corresponding human tumors...
  38. pmc N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma
    Jessica D Kessler
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 23:157-70. 2009
    ..We identified a preneoplastic stage in the patched (ptc) mutant mouse, a model for the brain tumor medulloblastoma...
  39. doi Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity
    Yannis E Mavromatakis
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Mech Dev 128:90-103. 2011
    ..Altogether, these data indicate that Foxa1 and Foxa2 contribute to the specification of ventral midbrain progenitor identity by regulating Shh signalling in a positive and negative manner...
  40. ncbi Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
    S Bellusci
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 124:53-63. 1997
    ..Here, we report that transcripts of mouse patched (Ptc), the homologue of a Drosophila gene encoding a putative transmembrane protein required for hedgehog signaling, are ..
  41. pmc Patched1 interacts with cyclin B1 to regulate cell cycle progression
    E A Barnes
    Department of Chemistry and Biochemistry, Center for Molecular Genetics, University of California San Diego, La Jolla, CA 92093 0367, USA
    EMBO J 20:2214-23. 2001
    ..a bait protein to mimic phosphorylated cyclin B1, we identified a novel interaction between cyclin B1 and patched1 (ptc1), a tumor suppressor associated with basal cell carcinoma (BCC)...
  42. ncbi Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation
    Lydia Koziel
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    Development 132:5249-60. 2005
    ..Furthermore the expression of the Ihh target genes patched (Ptch) and PTHrP is reactivated in Ihh-/-;Gli3-/- mutants...
  43. ncbi Identification of a unique transgenic mouse line that develops megabladder, obstructive uropathy, and renal dysfunction
    Sunita Singh
    Columbus Children s Research Institute, 700 Children s Drive, Suite WA 2014, Columbus, OH 43205, USA
    J Am Soc Nephrol 18:461-71. 2007
    ..The mgb mouse represents an excellent model for the study of normal and pathogenic bladder development, including the postnatal progression of chronic renal failure that results from the development of in utero obstructive uropathy...
  44. ncbi Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development
    Matthew M Goddeeris
    Departments of Cell Biology and Pediatrics, Neonatal Perinatal Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Development 134:1593-604. 2007
    ..Disruption of any of these steps can result in a single OFT phenotype...
  45. pmc A primary cilia-dependent etiology for midline facial disorders
    Samantha A Brugmann
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305, USA
    Hum Mol Genet 19:1577-92. 2010
    ..excessive Hedgehog responsiveness in facial mesenchyme, which is accompanied by broader expression domains of Gli1, Ptc and Shh, and reduced expression domains of Gli3...
  46. pmc Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis
    Eunice Y Lee
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford, CA, USA
    Proc Natl Acad Sci U S A 107:9736-41. 2010
    ..The results indicate that transformation of normal GNPs into deadly tumor cells is accompanied by a distinct set of Gli-regulated genes and may provide candidates for targeted therapies...
  47. pmc Pleiotropic role for MYCN in medulloblastoma
    Fredrik J Swartling
    University of California at San Francisco, San Francisco, California 94158, USA
    Genes Dev 24:1059-72. 2010
    ..Targeted expression of MYCN thus contributes to initiation, progression, and maintenance of MB, suggesting a central role for MYCN in pathogenesis...
  48. pmc Role of epidermal primary cilia in the homeostasis of skin and hair follicles
    Mandy J Croyle
    Department of Cell Biology, University of Alabama at Birmingham Medical School, Birmingham, AL 35294, USA
    Development 138:1675-85. 2011
    ..Collectively, these data indicate that epidermal primary cilia may function in stress responses and epidermal homeostasis involving pathways other than those typically associated with primary cilia...
  49. doi Hydroxysteroid (17beta) dehydrogenase 7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos
    Heli Jokela
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Endocrinology 151:1884-92. 2010
    ..The septum of the atrium was also defected in the knockout mice...
  50. pmc Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice
    Ryan B Corcoran
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Cancer Res 68:8788-95. 2008
    ..Mutations in the Shh receptor gene patched1 (ptc1+/-) lead to increased MB incidence in humans and mice...
  51. doi Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis
    Kazushi Aoto
    Molecular Neuropathology Group, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Dev Biol 327:106-20. 2009
    ..These findings provide new insight into the mechanism underlying HPE pathoetiology during dynamic brain and craniofacial morphogenesis...
  52. pmc Sonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome
    Martyn T Cobourne
    Department of Craniofacial Development and Orthodontics, Dental Institute, King s College London, Floor 27, Guy s Hospital, London SE1 9RT, UK
    Dev Biol 331:38-49. 2009
    ..Causative mutations for NBCCS occur in the PTCH1 gene on chromosome 9q22.3-q31, which encodes the principle receptor for the Hedgehog signalling pathway...
  53. ncbi Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
    H Hahn
    Section on Genetics, National Institute of Mental Health, Bethesda, MD 20892, USA
    Nat Med 4:619-22. 1998
    ..The syndrome results from germline mutations of the human homolog of the drosophila segment polarity gene patched (ptc)...
  54. pmc Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis
    Humphrey Hung Chang Yao
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 16:1433-40. 2002
    ..Based on the sex-specific expression patterns of Desert Hedgehog (Dhh) and its receptor Patched 1 (Ptch1) in XY gonads, we investigated the potential role of DHH/PTCH1 signaling in the origin and specification of fetal ..
  55. ncbi Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice
    Yuichi Wakabayashi
    Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, California 94143, USA
    Nature 445:761-5. 2007
    ..Here we show that susceptibility to SCC is under the control of a carboxy-terminal polymorphism in the mouse Ptch gene...
  56. doi Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma
    Ryan J Ward
    Developmental and Stem Cell Biology, Hospital for Sick Children, ON, Canada M5G 1X8
    Cancer Res 69:4682-90. 2009
    ....
  57. pmc The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization
    Kyu Sang Joeng
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 136:4177-85. 2009
    ..These results therefore provide direct genetic evidence that Gli2 and Gli3 collectively mediate all major aspects of Ihh function during endochondral skeletal development...
  58. ncbi Patched haploinsufficient mouse rhabdomyosarcoma overexpress secreted phosphoprotein 1 and matrix metalloproteinases
    Massimiliano De Bortoli
    Texas Children s Cancer Center, Department of Pediatrics, Baylor College of Medicine, 6621 Fannin Street, MC 3 3320 Houston, TX 77030, USA
    Eur J Cancer 43:1308-17. 2007
    ..Patched haploinsufficient (Ptch+/-) mice spontaneously develop soft tissue sarcomas that resemble human rhabdomyosarcomas...
  59. pmc Reduced white fat mass in adult mice bearing a truncated Patched 1
    Zili Li
    Birth Defects Center, Department of Molecular, Cellular, Craniofacial Biology, University of Louisville Health Sciences Center, Louisville, KY 40202, USA
    Int J Biol Sci 4:29-36. 2008
    ..total white fat mass and epididymal adipocyte cell size were observed in naturally occurring spontaneous mesenchymal dysplasia (mes) adult mice (Ptc1(mes/mes)), which carry a deletion of Ptc1 at the carboxyl-terminal cytoplasmic ..
  60. doi A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning
    Jean Denis Bénazet
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Science 323:1050-3. 2009
    ..This self-regulatory signaling network results in robust regulation of distal limb development that is able to compensate for variations by interconnectivity among the three signaling pathways...
  61. pmc Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation
    Ricardo C Moraes
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 136:1423-32. 2009
    ..Using phenotypic and transplantation analyses of mice carrying the mesenchymal dysplasia (mes) allele of patched 1 (Ptch1(mes)), we found that Ptch1(mes) homozygosity led to either complete ..
  62. doi Expression of Patched-1 and Smoothened in testicular meiotic and post-meiotic cells
    Carlos R Morales
    Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
    Microsc Res Tech 72:809-15. 2009
    ..Little is known about the involvement in spermatogenesis of the prototypic member of the family, Ptc1, which acts to suppress hedgehog signaling through Smoothened (Smo)...
  63. pmc Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis
    Takehiko Matsushita
    Department of Orthopaedics, Case Western Reserve University, 2109 Adelbert Road, BRB 329, Cleveland, OH 44106, USA
    Mol Cell Biol 29:5843-57. 2009
    ..Thus, our results indicate that ERK1 and ERK2 not only play essential roles in the lineage specification of osteo-chondroprogenitor cells but also support osteoclast formation in vivo...
  64. doi Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb
    Natalie C Butterfield
    The University of Queensland, Institute for Molecular Bioscience, Queensland, Australia
    Development 136:3515-24. 2009
    The vertebrate hedgehog receptor patched 1 (Ptc1) is crucial for negative regulation of the sonic hedgehog (Shh) pathway during anterior-posterior patterning of the limb...
  65. ncbi A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve
    V A Wallace
    Medical Research Council Developmental Neurobiology Programme, MRC Laboratory for Molecular Cell Biology and the Biology Department, University College London, London WC1E 6BT, UK
    Development 126:2901-9. 1999
    ..2) Astrocytes and their precursors in the developing optic nerve express the Hedgehog (Hh) receptor gene Patched (Ptc), suggesting that they are being signalled by an Hh protein...
  66. ncbi Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification
    Lydia Koziel
    Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Dev Cell 6:801-13. 2004
    ..Finally, we propose that the development of exostoses in the human Hereditary Multiple Exostoses syndrome can be attributed to activation of Ihh signaling...
  67. pmc Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification
    Masaki Inada
    Center for Immunology and Inflammatory Diseases, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Building 149, 13th Street, Room 8301, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 101:17192-7. 2004
    ..Cartilaginous growth plate abnormalities persisted in adult mice and phenocopied defects observed in human hereditary chondrodysplasias. Our findings demonstrate a unique role of Mmp13 in skeletal development...
  68. ncbi Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
    Wei Zhang
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Cell 10:657-65. 2006
    ..Specific Cdo domains required for its promyogenic effect are dispensable for its Shh signaling role, suggesting that Cdo has multiple, independent functions...
  69. ncbi Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina
    A M Jensen
    MRC Developmental Neurobiology Programme, University College London, UK
    Development 124:363-71. 1997
    ..These findings suggest that hedgehog and patched are part of a conserved signalling pathway in retinal development in mammals and insects...
  70. ncbi Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
    D Buscher
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Germany
    Mech Dev 62:175-82. 1997
    ..The transcript of Ptc, the putative receptor for Shh protein, can be detected anteriorly as well...
  71. ncbi Evidence for the involvement of the Gli gene family in embryonic mouse lung development
    J C Grindley
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee, 37232 2175, USA
    Dev Biol 188:337-48. 1997
    ..stage, coincident with a decline in the expression of sonic hedgehog (Shh) and the hedgehog receptor gene, patched (Ptc). Overexpression of Shh in the lung results in increased levels of Ptc mRNA...
  72. ncbi Sonic hedgehog is not required for polarising activity in the Doublefoot mutant mouse limb bud
    C Hayes
    Department of Human Anatomy, University of Oxford, UK
    Development 125:351-7. 1998
    ..is sufficient to fulfil the signalling properties of Shh including upregulation of the direct Shh target genes Ptc and Gli, and induction of the downstream target genes Bmp2, Fgf4 and Hoxd13...
  73. ncbi Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling
    Y Yang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, MA 02138, USA
    Development 125:3123-32. 1998
    ..In addition, specific components in the Hedgehog pathway are either ectopically activated (Ptc, Ptc-2, Gli1) or repressed (Gli2)...
  74. ncbi Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
    J Motoyama
    Programs in Developmental Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Nat Genet 20:54-7. 1998
    ..These results indicate that Gli2 and Gli3 possess specific and overlapping functions in Shh signalling during foregut development, and suggest that mutations in GLI genes may be involved in human foregut malformations...
  75. ncbi Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
    P T Chuang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 397:617-21. 1999
    ..Signalling is activated by binding of Hedgehog protein to the multipass membrane protein Patched (Ptc)...
  76. ncbi Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells
    D H Rowitch
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 19:8954-65. 1999
    ..Thus, Hedgehog signaling may contribute to CNS tumorigenesis by directly enhancing proliferation and preventing neural differentiation in selected precursor cells...
  77. ncbi Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1
    M T Lewis
    Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA
    Development 126:5181-93. 1999
    ..We have investigated the role of the Patched-1 (Ptc1) hedgehog receptor gene in mammary development and neoplasia...
  78. ncbi Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function
    C Chiang
    Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Dev Biol 236:421-35. 2001
    ..According to this model, the limb bud signaling centers, including the zone of polarizing activity (ZPA) acting through Shh, are required to elaborate upon the axial information provided by the native limb field prepattern...
  79. ncbi The transcription factors L-Sox5 and Sox6 are essential for cartilage formation
    P Smits
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Cell 1:277-90. 2001
    ..L-Sox5 and Sox6 are thus redundant, potent enhancers of chondroblast functions, thereby essential for endochondral skeleton formation...
  80. pmc Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18
    Zhonghao Liu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 16:859-69. 2002
    ..These data demonstrate that FGF18 signals through another FGFR to regulate osteoblast growth. Signaling to multiple FGFRs positions FGF18 to coordinate chondrogenesis in the growth plate with osteogenesis in cortical and trabecular bone...
  81. ncbi Sonic hedgehog and the molecular regulation of mouse neural tube closure
    Patricia Ybot-Gonzalez
    Neural Development Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Development 129:2507-17. 2002
    ..Attachment of surface ectoderm cells to the neural plate is required for dorsolateral bending, which ensures neural tube closure in the absence of sonic hedgehog signaling...
  82. ncbi Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells
    Ya Ping Wang
    Molecular Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Nat Neurosci 5:831-2. 2002
    ..Here we show that Sonic hedgehog signaling from RGCs is required for the normal laminar organization in the vertebrate retina...
  83. ncbi Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 129:4753-61. 2002
    ..to the defects seen when the Shh pathway is inappropriately activated and Gli1 transcription is induced, Gli1;Ptc double mutants were generated...
  84. ncbi Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development
    Gabriel D Dakubo
    Molecular Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
    Development 130:2967-80. 2003
    ..Together, these data provide a novel insight into the source of Hh that promotes neuroepithelial cell development in the mammalian optic disc and stalk...
  85. ncbi Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification
    Jun Motoyama
    Molecular Neuropathology Group, Brain Research Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Dev Biol 259:150-61. 2003
    ..Mutants lacking Patched1 (Ptc1), the putative receptor of Shh, were used to analyze Gli functions...
  86. ncbi Abnormalities of the vitreoretinal interface caused by dysregulated Hedgehog signaling during retinal development
    Graeme C M Black
    Academic Unit of Medical Genetics and Regional Genetic Service, St Mary s Hospital, Manchester, UK
    Hum Mol Genet 12:3269-76. 2003
    Mutations in Patched (PTCH), encoding the Hedgehog (Hh) receptor, underlie Basal Cell Naevus syndrome (BCNS) and, in addition to tumor predisposition, are associated with a wide range of 'patterning' defects...
  87. ncbi Persistent progenitors at the retinal margin of ptc+/- mice
    Ala Moshiri
    Neurobiology and Behavior Program, Department of Biological Structure, University of Washington, School of Medicine, Seattle, Washington 98195, USA
    J Neurosci 24:229-37. 2004
    ..retinal progenitor proliferation, we analyzed mice with a single functional allele of the Shh receptor patched (ptc)...
  88. pmc Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 113:188-99. 2004
    ..These findings indicate that the insoluble VEGF(188) isoform is insufficient for establishing epiphyseal vascularization and regulating cartilage development during endochondral bone formation...
  89. ncbi FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues
    Oleg V Bulgakov
    The Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Development 131:2149-59. 2004
    ..Although it is expressed broadly, FKBP8 is required to antagonize SHH signaling primarily in neural tissues, suggesting that hedgehog signal transduction is subject to cell-type specific modulation during mammalian development...
  90. pmc Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia
    Juhee Jeong
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Genes Dev 18:937-51. 2004
    ..Further, our analysis of Shh-Fox gene regulatory interactions leads us to propose that Fox genes mediate the action of Shh in facial development...
  91. ncbi Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
    Aimin Liu
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Mailstop 8322, Box 6511, Aurora, CO 80045, USA
    Development 132:3103-11. 2005
    ..Sonic hedgehog (Shh) expression is normal, yet Ptch1 and Gli1, two known targets of Hh signaling, are greatly reduced, consistent with loss of Shh signaling...
  92. ncbi Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning
    Steven A Vokes
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 134:1977-89. 2007
    ..Together, these approaches provide significant new insights into both tissue-specific and general transcriptional targets in a crucial Shh-mediated patterning process...
  93. pmc Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
    Maisa Seppala
    Department of Craniofacial Development, Dental Institute, King s College London, London, United Kingdom
    J Clin Invest 117:1575-84. 2007
    ..As human GAS1 maps to chromosome 9q21.3-q22, a region previously associated with nonsyndromic cleft palate and congenital deafness, our results establish GAS1 as a potential locus for several human craniofacial malformations...
  94. ncbi Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
    D J Epstein
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 122:2885-94. 1996
    ..Two mammalian target genes that are strongly expressed in ectopic dorsal locations in response to dnPKA are Ptc and Gli...
  95. ncbi Hedgehog and patched gene expression in adult ocular tissues
    T Takabatake
    Radioisotope Research Center, Nagoya University, Japan
    FEBS Lett 410:485-9. 1997
    ..We also found that two types of ptc genes, potential hh targets and receptors, were expressed in these tissues, suggesting the presence of active hh ..
  96. ncbi Sonic hedgehog signaling is essential for hair development
    B St-Jacques
    Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1058-68. 1998
    ..To address the role of Shh in the hair follicle, we have examined Shh null mutant mice...
  97. ncbi Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    C V Pepicelli
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1083-6. 1998
    ..In addition, the transcription of several mesenchymally expressed downstream targets of Shh is abolished. These results highlight the importance of epithelially derived Shh in regulating branching morphogenesis of the lung...
  98. ncbi Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum
    V A Wallace
    Ottawa General Hospital Research Institute, University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Curr Biol 9:445-8. 1999
    ..express the gene encoding the morphogen Sonic hedgehog (Shh) and that dividing cells in the EGL express Patched (Ptc) and Gli1, two target genes of which expression is upregulated in response to Hedgehog signalling (see [5] and ..
  99. ncbi Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
    M Aszterbaum
    Department of Dermatology, University of California San Francisco, Building 100, Room 269, 1001 Potrero Ave, San Francisco, California 94110, USA
    Nat Med 5:1285-91. 1999
    ..the commonest human skin cancers, consistently have abnormalities of the hedgehog signaling pathway and often have PTCH gene mutations...
  100. ncbi Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
    I Satokata
    Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 24:391-5. 2000
    ..Our results provide a developmental basis for PFM and demonstrate that Msx2 is essential at multiple sites during organogenesis...
  101. ncbi Some distal limb structures develop in mice lacking Sonic hedgehog signaling
    P Kraus
    Ronald O Perelman Department of Dermatology, New York University School of Medicine, NY, New York, USA
    Mech Dev 100:45-58. 2001
    ..Finally, we show that Shh is also required for outgrowth of the limb ectoderm and thus for the formation of a distinct limb compartment...

Research Grants12

  1. TG737 SIGNALING PATHWAY AND POLYCYSTIC KIDNEY
    Bradley Yoder; Fiscal Year: 2003
    ..Overall, results generated from this proposal will give important insight into the biological function of Tg737 and how disruption of the Tg737/polycystin-1 signaling pathway results in the formation of renal cyst. ..
  2. Cilial dysfunction and pathogenesis of obesity
    Bradley K Yoder; Fiscal Year: 2010
    ....
  3. Conserved Mechanisms of Ciliogenesis
    Bradley Yoder; Fiscal Year: 2007
    ..abstract_text> ..
  4. GENETICS OF A TRANSGENIC MOUSE MODEL FOR NEUROBLASTOMA
    William Weiss; Fiscal Year: 2004
    ..Given the poor outcome associated with childhood neuroblastoma, this work has the potential to increase our understanding of the pathogenesis of neuroblastoma, and may result in improved therapies for children with this disorder. ..
  5. Hedgehog Pathway in Urogenital Sinus Development
    David Berman; Fiscal Year: 2005
    ..The aim of the mentored training period is to acquire the necessary intellectual and technical skills to transition into independent investigation of urogenital development and its relationships to urologic disease. ..
  6. Imaging Kinase Activity In Vivo
    William Weiss; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  7. Eda/Edar Regulation of Embryonic SMG Development
    Tina Jaskoll; Fiscal Year: 2007
    ....
  8. Small RNAs in skeletogenesis
    Tatsuya Kobayashi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2008
    ..Also, expression of Shh, Ptc, Fgfl0 and Bmp4 are all increased in Wnt5a(-/-) lungs...
  10. Hedgehog signaling links bladder injury and cancer
    DAVID MONTY BERMAN; Fiscal Year: 2010
    ..4) To test whether continuously enforced Hh signaling is sufficient to induce urothelial carcinogenesis. ..
  11. Roles for HIC1 in neural development and tumor suppression
    DAVID NEIL WATKINS; Fiscal Year: 2010
    ..These findings are of direct relevance to many cancers, since deregulation of pathways known to be important in embryonic development can help us understand the basis of human malignancy. ..