Genomes and Genes
Gene Symbol: Rb1
Description: RB transcriptional corepressor 1
Alias: Rb-1, pRb, retinoblastoma-associated protein, pp105, retinoblastoma 1
Publications177 found, 100 shown here
- Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycleB G Novitch
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Cell Biol 135:441-56. 1996Viral oncoproteins that inactivate the retinoblastoma tumor suppressor protein (pRb) family both block skeletal muscle differentiation and promote cell cycle progression...
- Genetic determinants of malignancy in a mouse model for oligodendrogliomaWilliam A Weiss
Department of Neurology, University of California, San Francisco, California 94143 0663, USA
Cancer Res 63:1589-95. 2003..These models hold promise for studying tumor lineage, identifying contributing genetic alterations and evaluating preclinical therapies in this important neoplasm...
- shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during developmentChristopher A Fasano
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
Cell Stem Cell 1:87-99. 2007..Understanding stage-related mechanisms underlying NSC self-renewal has important implications for development of stem cell-based therapies...
- Rb regulates fate choice and lineage commitment in vivoEliezer Calo
David H Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nature 466:1110-4. 2010..Numerous functions have been ascribed to the product of the human RB1 gene, the retinoblastoma protein (pRb)...
- Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressiveCourtney H Coschi
London Regional Cancer Program, University of Western Ontario, London, Ontario, Canada
Genes Dev 24:1351-63. 2010..In this report, we demonstrate that the retinoblastoma protein (pRB), a well-known regulator of progression through the G1 phase of the cell cycle, plays a critical role in mitotic ..
- Defining the regulatory networks for muscle developmentJ D Molkentin
Hamon Center for Basic Research in Cancer, University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, 75235 9148, USA
Curr Opin Genet Dev 6:445-53. 1996..Elucidation of these aspects of the myogenic program is leading to a detailed understanding of the regulatory circuits controlling muscle development...
- Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditionsJ H Dannenberg
The Netherlands Cancer Institute, Division of Molecular Biology, 1066 CX Amsterdam, The Netherlands
Genes Dev 14:3051-64. 2000The retinoblastoma suppressor pRB belongs to the family of so-called pocket proteins, which also includes p107 and p130. These proteins may functionally overlap in cell cycle control and tumor suppression...
- MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cellsShipeng Feng
Lab for RNA Chemical Biology at Guangzhou Institutes of Biomedicine and Health, Chinese Academic of Science, Guangzhou 510530, China
Nucleic Acids Res 39:6669-78. 2011..Further studies showed that retinoblastoma 1 (RB1) is a direct target of miR-192...
- Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exitAlexandre Blais
Department of Biochemistry, Microbiology, and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa K1H 8M5, Canada
J Cell Biol 179:1399-412. 2007The retinoblastoma tumor suppressor protein (pRb) is involved in mitotic exit, promoting the arrest of myoblasts, and myogenic differentiation. However, it is unclear how permanent cell cycle exit is maintained in differentiated muscle...
- RB status governs differential sensitivity to cytotoxic and molecularly-targeted therapeutic agentsKristy R Stengel
Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Cell Cycle 7:1095-103. 2008..These results indicate that RB status differentially impacts therapeutic response and should be considered when evaluating the efficacy of molecularly targeted therapeutics...
- Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene familyPatrick Viatour
Department of Pediatrics, Stanford Medical School, Stanford, CA 94305, USA
Cell Stem Cell 3:416-28. 2008..The presence of a single p107 allele is sufficient to largely rescue these defects. Thus, Rb family members collectively maintain HSC quiescence and the balance between lymphoid and myeloid cell fates in the hematopoietic system...
- Retinoblastoma loss modulates DNA damage response favoring tumor progressionMarcos Seoane
Molecular Oncology Lab, Departamento de Fisioloxia, Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
PLoS ONE 3:e3632. 2008..In this scenario, the absence of pRb confers a proliferative advantage and activates DDR to a greater extent in a DNA lesion-independent fashion than ..
- G1 arrest and differentiation can occur independently of Rb family functionStacey E Wirt
Department of Pediatrics, Stanford Medical School, Stanford, CA 94305, USA
J Cell Biol 191:809-25. 2010....
- A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude miceRebecca Kinkade
Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Cancer Res 68:3810-8. 2008..Thus, selective targeting of Rb/Raf-1 interaction seems to be a promising approach for developing novel chemotherapeutic agents...
- E2f3a and E2f3b contribute to the control of cell proliferation and mouse developmentJean Leon Chong
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
Mol Cell Biol 29:414-24. 2009..Together, we conclude that the contributions of E2F3a and E2F3b in cell proliferation and development are context dependent...
- E2f1-3 switch from activators in progenitor cells to repressors in differentiating cellsJean Leon Chong
Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Nature 462:930-4. 2009..This work contextualizes the activator versus repressor functions of E2f1-3 in vivo, revealing distinct roles in dividing versus differentiating cells and in normal versus cancer-like cell cycles...
- Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 statusZhe Jiang
Division of Cell and Molecular Biology, Toronto General Research Institute University Health Network, Toronto, Ontario, Canada
J Clin Invest 120:3296-309. 2010..The tumor suppressor gene retinoblastoma 1 (RB1) is frequently lost in both luminal-B and triple-negative tumor (TNT; i.e...
- Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6Marcos Malumbres
Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas CNIO, E 28029 Madrid, Spain
Cell 118:493-504. 2004..These results indicate that D-type cyclin-dependent kinases are not essential for cell cycle entry and suggest the existence of alternative mechanisms to initiate cell proliferation upon mitogenic stimulation...
- Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesisZahra Kadri
CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay aux Roses, France
PLoS Biol 7:e1000123. 2009..that GATA-1, the master transcription factor of erythropoiesis, forms a tricomplex with the retinoblastoma protein (pRb) and E2F-2...
- Retinoblastoma 1 protein modulates XY germ cell entry into G1/G0 arrest during fetal development in miceCassy M Spiller
Division of Molecular Genetics and Development, and Australian Research Council Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
Biol Reprod 82:433-43. 2010..5 days postcoitum (dpc). Retinoblastoma 1 (RB1), a potent cell cycle regulator, was investigated in XY germ cell arrest by studying germ cell ..
- pRb is necessary for inhibition of N-myc expression by TGF-beta 1 in embryonic lung organ culturesR Serra
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
Development 121:3057-66. 1995..Indirect evidence has indicated that the product of the retinoblastoma gene (pRb) may also be involved in this pathway...
- Chromosomal assignment of retinoblastoma 1 gene (RB1) to mouse 14D3 and rat 15q12 by fluorescence in situ hybridizationT Ono
Chromosome Research Unit, Faculty of Science, Hokkaido University, Sapporo, Japan
Jpn J Genet 68:617-21. 1993The retinoblastoma 1 gene was assigned to mouse chromosome 14 at band D3 and rat chromosome 15 at band q12, respectively, by fluorescence in situ hybridization (FISH)...
- The proliferative and apoptotic activities of E2F1 in the mouse retinaS C Lin
Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio, Texas, TX 78245 3207, USA
Oncogene 20:7073-84. 2001..Our findings support the concept that cross-talk occurs between different retinal cell types and that multiple genetic pathways must become dysregulated for the full oncogenic transformation of neuronal retinal cells...
- Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivoJoshua L Dunaief
FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Curr Eye Res 24:392-6. 2002To identify and characterize retinoblastoma protein (pRb) binding proteins that may influence retinoblast proliferation and retinal pigment epithelial cell survival.
- Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatinSusana Gonzalo
Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre CNIO, Madrid E 28029, Spain
Nat Cell Biol 7:420-8. 2005..Mouse embryonic fibroblasts that are triply deficient for RB1 (retinoblastoma 1), RBL1 (retinoblastoma-like 1) and RBL2 (retinoblastoma-like 2) - known as TKO cells - show a marked genomic ..
- A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland developmentSarah M Francis
London Regional Cancer Program, University of Western Ontario, London, Ontario N6A4L6, Canada
Mol Cell Biol 29:4455-66. 2009..been shown to inhibit cyclin-dependent kinase (CDK) activity, which leads to the accumulation of hypophosphorylated pRB. However, unlike other components of TGF-beta cytostatic signaling, pRB is thought to be dispensable for mammary ..
- Rb and N-ras function together to control differentiation in the mouseChiaki Takahashi
Department of Medical Oncology and Medicine, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Mol Cell Biol 23:5256-68. 2003..Previous cell culture-based experiments have suggested that the retinoblastoma protein (pRb) and Ras operate in a common pathway to control cellular differentiation...
- The retinoblastoma gene family in differentiation and developmentM M Lipinski
Department of Biology, Massachusetts Institute of Technology, Center for Cancer Research, Cambridge 02139, USA
Oncogene 18:7873-82. 1999..They also play a critical role in assuring the orderly progression through all these stages of differentiation...
- Regulation of RB transcription in vivo by RB family membersDeborah L Burkhart
Department of Pediatrics, Stanford Medical School, 269 Campus Drive, CCSR1215, Stanford, CA 94305, USA
Mol Cell Biol 30:1729-45. 2010..These experiments identify novel regulatory feedback mechanisms within the RB pathway in mammalian cells...
- Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancerZongxiang Zhou
Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853 6401, USA
Cancer Res 66:7889-98. 2006..The new genetically defined model should be particularly valuable for providing new molecular insights into the pathogenesis of human prostate cancer...
- A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescenceSrikanth Talluri
Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
Mol Cell Biol 30:948-60. 2010..Here we show that the retinoblastoma protein (pRB) uses a mechanism to block DNA replication in senescence that is distinct from its role in permanent cell cycle ..
- A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradationBrett R Johnson
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 101:9677-82. 2004The retinoblastoma protein (pRB) is a critical regulator of cell proliferation and differentiation and an important tumor suppressor...
- The Rb tumor suppressor is required for stress erythropoiesisBenjamin T Spike
The Ben May Institute for Cancer Research, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
EMBO J 23:4319-29. 2004..Early studies using gene targeting in mice suggested a critical role for pRb in erythropoiesis, while more recent experiments have suggested that many of the abnormal embryonic phenotypes in ..
- Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructsH te Riele
Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
Proc Natl Acad Sci U S A 89:5128-32. 1992..This result indicates that, also in mammalian cells, homologous recombination rather than random integration can be the predominant event...
- Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPsP L Chen
Institute of Biotechnology, The University of Texas Health Science Center at San Antonio 78245, USA
Genes Dev 10:2794-804. 1996..Such a role contrasts with the function of Rb in arresting cell cycle progression in G1 by negative regulation of other transcription factors like E2F-1...
- pRb and E2f-1 in mouse development and tumorigenesisK Macleod
Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK
Curr Opin Genet Dev 9:31-9. 1999..E2F-1 can induce both apoptosis and S-phase transition and whether E2F-1 acts as an oncogene or a tumor-suppressor gene may depend on the extent to which E2F-1 induces apoptosis as opposed to G1/S transition...
- Retinoblastoma gene promoter directs transgene expression exclusively to the nervous systemZ Jiang
Department of Medicine, University of Toronto and Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada M5G 2MI
J Biol Chem 276:593-600. 2001....
- Cutting edge: differential signaling requirements for activation of assembled cyclin D3-cdk4 complexes in B-1 and B-2 lymphocyte subsetsD A Tanguay
Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
J Immunol 166:4273-7. 2001..Although cyclin D2-cyclin-dependent kinase 4 (cdk4) complexes mediate early retinoblastoma gene product (pRb) phosphorylation in B-1 cells, the transient nature of their accumulation cannot account for the continued increase ..
- Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ductsZongxiang Zhou
Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853 6401, USA
Cancer Res 67:5683-90. 2007..These findings indicate that p53 and Rb are critically important for the regulation of the prostatic stem cell compartment, the transformation in which may lead to particularly aggressive cancers in the context of microenvironment...
- Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineageSeth D Berman
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 105:11851-6. 2008..Finally, we show that loss of Rb and p53 in Sca-1-positive mesenchymal stem/progenitor cells is sufficient to yield transformed cells that can initiate osteosarcoma formation in vivo...
- AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and glucose deprivation by down-regulating phospho-retinoblastoma protein and cyclin DYi Zang
National Center for Drug Screening and Neurological Pharmacology Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
J Biol Chem 284:6175-84. 2009..AMPK, but not JAK/STAT3, activation is key for this inhibitory effect and may play an important role in the responses of NSCs to metabolic stresses such as glucose deprivation...
- Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscleKostandin V Pajcini
Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell Stem Cell 7:198-213. 2010..These results show that differentiation of mammalian cells is reversed by inactivation of Arf and Rb and support the hypothesis that Arf evolved at the expense of regeneration...
- Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetranceN Hu
Center for Molecular Medicine Institute of Biotechnology, University of Texas, San Antonio 78284
Oncogene 9:1021-7. 1994..The Rb knock out mouse strain provides a unique model for addressing tissue-specific tumor predisposition by inactivation of a ubiquitously expressed tumor suppressor gene...
- pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesisE Zacksenhaus
Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
Genes Dev 10:3051-64. 1996..We have generated transgenic mice (RBlox) that express low levels of pRb, driven by an RB1 minigene...
- p107 is a suppressor of retinoblastoma development in pRb-deficient miceE Robanus-Maandag
Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Genes Dev 12:1599-609. 1998..In the mouse, however, Rb hemizygosity leaves the retina normal, whereas in Rb-/- chimeras pRb-deficient retinoblasts undergo apoptosis...
- The retinoblastoma gene family: cousins with overlapping interestsG Mulligan
Center for Cancer Research, Howard Hughes Medical Institute, Cambridge, MA, USA
Trends Genet 14:223-9. 1998The retinoblastoma tumor suppressor gene (RB1) and its relatives, p107 and p130, encode a family of proteins that share several properties, including the capacity to regulate E2F-dependent transcription and inhibit cell-cycle progression...
- Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellumS Marino
Division of Molecular Genetics and Centre of Biomedical Genetics, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands
Genes Dev 14:994-1004. 2000..Our results demonstrate that loss of function of RB is essential for medulloblastoma development in the mouse and strongly support the hypothesis that medulloblastomas arise from multipotent precursor cells located in the EGL...
- Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteinsA Lasorella
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Nature 407:592-8. 2000..Thus, a dual connection links Id2 and Rb: during normal cell-cycle, Rb prohibits the action of Id2 on its natural targets, but oncogenic activation of the Myc-Id2 transcriptional pathway overrides the tumour-suppressor function of Rb...
- E2F1 and p53 are dispensable, whereas p21(Waf1/Cip1) cooperates with Rb to restrict endoreduplication and apoptosis during skeletal myogenesisZ Jiang
Department of Medicine, Toronto General Hospital Research Institute, University Health Network, University of Toronto, 67 College Street, Toronto, Ontario, Canada
Dev Biol 227:8-41. 2000..Thus, combined inactivation of Rb and p21(Waf1/Cip1) augments endoreduplication and apoptosis, whereas E2F1 and p53 are dispensable during aberrant myogenesis in Rb-deficient fetuses...
- TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1S I Hsu
Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
EMBO J 20:2273-85. 2001....
- Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinomaZhe Jiang
Department of Medicine, University of Toronto, Ontario, Canada M5G 2M1
J Cell Biol 156:185-98. 2002....
- Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo memberShyng Shiou F Yuan
Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, ROC
Biochem Biophys Res Commun 296:1019-25. 2002..In summary, the ubiquitous tumor suppressor RB and the neuron-enriched transcription factor Pax-2 may play a role in the regulation of Rig-1 expression during embryogenesis...
- Extra-embryonic function of Rb is essential for embryonic development and viabilityLizhao Wu
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
Nature 421:942-7. 2003....
- Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growthHong Xin
Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Building No 1, Mail Code 114B, Maywood, IL 60153, USA
Oncogene 22:4775-85. 2003..Together, our observations support the idea that the transcriptional activation of Ifi202 gene by Rb/JunD may be important for the regulation of cell growth and survival...
- Rb regulates proliferation and rod photoreceptor development in the mouse retinaJiakun Zhang
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Nat Genet 36:351-60. 2004..a cell-autonomous manner, we used a replication-incompetent retrovirus encoding Cre recombinase to inactivate the Rb1(lox) allele in individual retinal progenitor cells in vivo...
- Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermisSergio Ruiz
Department of Cell and Molecular Biology and Gene Therapy, CIEMAT, Madrid E28040, Spain
Development 131:2737-48. 2004The retinoblastoma gene product, pRb, plays a crucial role in cell cycle regulation, differentiation and inhibition of oncogenic transformation...
- Cell type-specific effects of Rb deletion in the murine retinaDavid MacPherson
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Genes Dev 18:1681-94. 2004..Conditional Rb mutation in the retina did not result in retinoblastoma formation even in a p53-mutant background. However, on a p107- or p130-deficient background, Rb mutation in the retina caused retinal dysplasia or retinoblastoma...
- A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cellsGrazia Camarda
Depatment of Environment and Primary Prevention, Higher Institute of Health, 00161 Roma, Italy
J Cell Biol 167:417-23. 2004In skeletal muscle differentiation, the retinoblastoma protein (pRb) is absolutely necessary to establish definitive mitotic arrest...
- Developmental defects in Rb-deficient retinaeStacy L Donovan
Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
Vision Res 44:3323-33. 2004..Therefore, the retinae from Chx10-Cre;RbLox/- mice represent a unique model to study the role of rod photoreceptor inputs in horizontal cell differentiation and synapse formation...
- Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesisOriol Casanovas
Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California San Francisco, 94143, USA
Oncogene 24:6597-604. 2005....
- Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alphaAnthony Scime
Molecular Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
Cell Metab 2:283-95. 2005..mice contained markedly elevated numbers of adipogenic precursors that displayed downregulated expression of pRb. Consistent with the hypothesis that pRb is required for adult adipocyte differentiation, Cre-mediated deletion of ..
- Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune functionM P Markey
Department of Cell and Cancer Biology, University of Cincinnati, Cincinnati, OH 45267 0521, USA
Oncogene 26:6307-18. 2007....
- Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- miceGabriel M Gutierrez
Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 105:18402-7. 2008..We now show that pRb also plays a role early in osteogenesis, and that in primary RB1(-/-) calvarial cells there is an increased osteoprogenitor pool...
- Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defectsSeth D Berman
David H Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 106:14932-6. 2009The retinoblastoma tumor-suppressor protein, pRb, is a member of the pocket protein family that includes p107 and p130...
- Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cellsRoopa L Nalam
Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Mol Endocrinol 23:1900-13. 2009..Our results demonstrate that RB is essential for proper terminal differentiation of Sertoli cells...
- E2F-1 has dual roles depending on the cell cycleFikret Sahin
Department of Microbiology and Immunology, Finch University of Health Sciences Chicago Medical School now Rosalind Franklin University, 3333 Green Bay Road, North Chicago, Illinois 60064 3095, USA
Int J Biol Sci 6:116-28. 2010..E2F-1 is the major cellular target of pRB and is regulated by pRB during cell proliferation...
- E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomasUlrike Ziebold
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Mol Cell Biol 23:6542-52. 2003The E2F transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor...
- Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesisE Y Lee
Center for Molecular Medicine, University of Texas Health Science Center, San Antonio 78284
Nature 359:288-94. 1992..All spinal ganglion cells die, but the neural retina is unaffected. Transfer of the human retinoblastoma (RB) mini-transgene into the mutant mice corrects the developmental defects. Thus, Rb is essential for normal mouse development...
- Requirement for a functional Rb-1 gene in murine developmentA R Clarke
Department of Pathology, University of Edinburgh, UK
Nature 359:328-30. 1992..However, homozygous mutant embryos fail to reach term and show a number of abnormalities in neural and haematopoietic development. Broadly similar results are reported by the other groups...
- Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosisA Almasan
Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 92:5436-40. 1995....
- Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric miceE C Maandag
Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
EMBO J 13:4260-8. 1994..Moreover, the formation of lens fibre cells was severely disturbed. No retinoblastomas developed in any of these mice. Instead, nearly all animals died of pituitary gland tumours which were exclusively derived from Rb-1- cells...
- Cooperative tumorigenic effects of germline mutations in Rb and p53B O Williams
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
Nat Genet 7:480-4. 1994..These data indicate that mutations in Rb and p53 can cooperate in the transformation of certain cell types in the mouse...
- p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lensS D Morgenbesser
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461
Nature 371:72-4. 1994..This developmental system provides a framework for understanding the consequences of the frequent mutation of both RB and p53 in human cancer...
- Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblastsP Savatier
Laboratoire de Biologie Moleculaire et Cellulaire, CNRS UM R49, INRA, Ecole Normale Superieure de Lyon, France
Oncogene 9:809-18. 1994..Absence of hypophosphorylated RB and cell cycle-dependent change in total RB protein level may be relevant to the high proliferation rate and to the tumorigenic nature of mouse embryonic stem cells...
- Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cellsJ W Schneider
Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, MA 02115
Science 264:1467-71. 1994..Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb-/- myotubes...
- Targeted disruption of p107: functional overlap between p107 and RbM H Lee
Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
Genes Dev 10:1621-32. 1996..These results provide the first in vivo evidence that p107 and Rb have overlapping functions in some tissues of the developing and adult mouse...
- Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous systemK F Macleod
Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
EMBO J 15:6178-88. 1996..Although loss of p53 gene function prevents cell death in the CNS of Rb-mutant embryos, it does not restore normal proliferative control...
- The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosisS Herwig
Max Planck Gesellschaft, Humboldt Universitat, Max Delbrück Centrum for Molecular Medicine, Berlin Buch, Germany
Eur J Biochem 246:581-601. 1997The retinoblastoma susceptibility gene is a tumour suppressor and its product retinoblastoma protein (pRb) has been known for 10 years as a repressor of progression towards S phase...
- Retinoblastoma protein represses transcription by recruiting a histone deacetylaseL Magnaghi-Jaulin
Laboratoire Oncogenese, Differenciation et Transduction du Signal, CNRS UPR 9079, Villejuif, France
Nature 391:601-5. 1998..Our results strongly suggest that the Rb/HDAC1 complex is a key element in the control of cell proliferation and differentiation and that it is a likely target for transforming viruses...
- A critical temporal requirement for the retinoblastoma protein family during neuronal determinationR S Slack
Center for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Canada H3A 2B4
J Cell Biol 140:1497-509. 1998..To determine whether pRb is required for neuronal determination in vivo, we crossed the Rb-/- mice with transgenic mice expressing beta-..
- pRB is required for interferon-gamma-induction of the MHC class II abeta geneX Zhu
Eye Research Institute for Canada, 399 Bathurst Street, Toronto, Ontario, Canada, M5T 2S8
Oncogene 18:4940-7. 1999b>pRB is required for IFN-gamma-induction of MHC class II in human tumor cell lines, providing a potential link between tumor suppressors and the immune system...
- The Rb-CDK4/6 signaling pathway is critical in neural precursor cell cycle regulationK L Ferguson
Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
J Biol Chem 275:33593-600. 2000..Furthermore, our data underscore the importance of the Rb regulatory pathway in neuronal development and cell cycle regulation, independent of CKI sequestration...
- Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalizationJ Sage
Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Genes Dev 14:3037-50. 2000The retinoblastoma protein, pRB, and the closely related proteins p107 and p130 are important regulators of the mammalian cell cycle...
- E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryosU Ziebold
Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Genes Dev 15:386-91. 2001The E2F transcription factors are thought to be key downstream targets of the retinoblastoma protein (pRB) tumor suppressor...
- The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiationD M Thomas
Department of Pathology and, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Mol Cell 8:303-16. 2001..To understand why the retinoblastoma protein (pRb) is specifically targeted in osteosarcoma, we studied its function in osteogenesis...
- Functional mammary gland development and oncogene-induced tumor formation are not affected by the absence of the retinoblastoma geneG W Robinson
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
Oncogene 20:7115-9. 2001..We investigated the consequences of the absence of pRb in mammary epithelial cells during normal development and in mice that express an oncogene in the mammary ..
- Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of RbHarold I Saavedra
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics and Department of Molecular Genetics, The Ohio State University, Columbus 43210, USA
Cell Growth Differ 13:215-25. 2002..These results provide clear evidence for functional specificity among E2Fs in the control of Rb-dependent proliferation and apoptosis in a tissue-specific manner...
- Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cellsMarc Vooijs
Division of Molecular Genetics, The Netherlands Cancer Institute Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Oncogene 21:4635-45. 2002..Our results highlight the important differences that exist in tumor susceptibility between mice and man (e.g pineal gland) and question the photoreceptor cell origin of human retinoblastoma...
- Loss of Rb overrides the requirement for ERK activity for cell proliferationGiovanna M D'Abaco
Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
J Cell Sci 115:4607-16. 2002..Analysis of Rb-deficient tumour cell lines also revealed a reduced requirement for ERK signalling in asynchronous growth. We discuss the molecular mechanism that may underlie this escape from MAP kinase signalling...
- E2F4 loss suppresses tumorigenesis in Rb mutant miceEunice Y Lee
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cancer Cell 2:463-72. 2002..the activation or repression of key cell cycle regulatory genes under the control of the retinoblastoma protein (pRB) tumor suppressor and its relatives, p107 and p130...
- Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient miceAlain de Bruin
Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus 43210, USA
Proc Natl Acad Sci U S A 100:6546-51. 2003....
- Distinct gene expression phenotypes of cells lacking Rb and Rb family membersEsther P Black
Department of Molecular Genetics and Microbiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
Cancer Res 63:3716-23. 2003..We suggest that this is an approach to the eventual understanding of gene regulatory pathways that define a phenotypic state, including those events that lead to tumor development...
- Differential regulation of apoptotic genes by Rb in human versus mouse cellsArthur P Young
Department of Medicine, Washington University School of Medicine, 4940 Parkview Place, St Louis, MO 63110, USA
Oncogene 23:2587-99. 2004....
- Geminin is targeted for repression by the retinoblastoma tumor suppressor pathway through intragenic E2F sitesMichael Markey
Department of Cell Biology, University of Cincinnati, Vontz Center for Molecular Studies, Cincinnati, Ohio 45267 0521, USA
J Biol Chem 279:29255-62. 2004..Together, these data link the expression of geminin to the RB/E2F pathway and represent the first promoter analysis of this important regulator of DNA replication...
- Cell-intrinsic requirement for pRb in erythropoiesisAllison J Clark
Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria 8006, Australia
Blood 104:1324-6. 2004..In particular, accumulated data have suggested that the Rb gene product pRb is an important controller of erythroid differentiation...
- Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastomaDanian Chen
Toronto Western Research Institute, University Health Network, Vision Science Research Program, Department of Ophthalmology and Visual Sciences, University of Toronto, 399 Bathurst Street, Toronto, Ontario, Canada, M5T 2S8
Cancer Cell 5:539-51. 2004..We suggest that additional lesions common in retinoblastoma overcome growth arrest, not apoptosis...
- Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiationMichael S Huh
Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada, K1H 8L6
J Cell Biol 166:865-76. 2004To investigate the requirement for pRb in myogenic differentiation, a floxed Rb allele was deleted either in proliferating myoblasts or after differentiation...
- Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophagesAntonio Iavarone
Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Nature 432:1040-5. 2004..1, a master regulator of macrophage differentiation. Thus, Rb has a cell autonomous function in fetal liver macrophages, and restrains Id2 in these cells in order to implement definitive erythropoiesis...
- Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of RbW R MacLellan
Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, 675 C E Young Dr, MRL 3 645, Los Angeles, CA 90095 1760, USA
Mol Cell Biol 25:2486-97. 2005..Thus, Rb and p130 have overlapping functional roles in vivo to suppress cell cycle activators, including Myc, and maintain quiescence in postnatal cardiac muscle...
- Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant miceAnna Lasorella
Institute for Cancer Genetics, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
Mol Cell Biol 25:3563-74. 2005..In human neuroblastoma, the N-Myc-driven expression of Id2 is sufficient and necessary for expression of VEGF. These results establish that aberrant Id2 activity directs initiation and progression of embryonal cancer...
- The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner earJohanna Mantela
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Development 132:2377-88. 2005..We show here that the retinoblastoma gene Rb and the encoded protein pRb are expressed in differentiating and mature hair cells...
- Molecular Mechanisms Regulating Stem Cell PlasticityMichael Rudnicki; Fiscal Year: 2004..To investigate the mechanism by which Pax7 enforces lineage commitment, FACS/Hoechst enriched adult stem cells from Pax7-/- mice will be transplanted either intravenously or intramuscularly. ..
- Parathyroid Hormone Related Protein in the Human IsletRupangi Vasavada; Fiscal Year: 2005..Studies of this nature would be a critical first step towards reducing the number of islets required for successful transplantation. ..
- Analysis of transcription in lens using tiled microarrays (ChIP on chip)Ales Cvekl; Fiscal Year: 2007..5 key transcription factors regulating lens lineage formation, Pax6 and Sox2, and differentiation (c-Maf, Proxl and pRb) with nearly 100 genes/loci encoding proteins essential for lens development and homeostasis; and (2) Identify ..
- C/EBP alpha in Aging LiverNikolai Timchenko; Fiscal Year: 2009..Based on data obtained in this project, we are planning to start developing a strategy to correct liver proliferation in elderly. ..
- ID2 IN CELL CYCLE REGULATION AND CANCERAntonio Iavarone; Fiscal Year: 2010..The proposed work will define the mechanisms underlying regulation of Id2 and enhance our understanding of the involvement of uncontrolled Id2 activity in human cancer. ..
- Requirements for Normal Rb Function In VivoDavid W Goodrich; Fiscal Year: 2010..Rb1 protein (pRb) is a negative regulator of the cell cycle, and this cell cycle regulatory activity contributes to tumor ..
- The Role of Thoc1 in Normal Development and CancerDavid W Goodrich; Fiscal Year: 2011..The experiments proposed will determine whether pThod is a promising target for the development of new therapies and prognostic tests. ..
- GENETIC ANALYSIS OF CARDIAC TERMINAL DIFFERENTIATIONW MacLellan; Fiscal Year: 2003..This first RO1 proposes to further define the role of PRI-1 in cardiac myocyte differentiation and elucidate its biochemical properties. ..
- GENETICS OF A TRANSGENIC MOUSE MODEL FOR NEUROBLASTOMAWilliam Weiss; Fiscal Year: 2004..Given the poor outcome associated with childhood neuroblastoma, this work has the potential to increase our understanding of the pathogenesis of neuroblastoma, and may result in improved therapies for children with this disorder. ..
- Imaging Kinase Activity In VivoWilliam Weiss; Fiscal Year: 2006..unreadable] [unreadable]..
- Lactogens and Pancreatic Beta Cell SurvivalRupangi Vasavada; Fiscal Year: 2009..abstract_text> ..