Rb1

Summary

Gene Symbol: Rb1
Description: RB transcriptional corepressor 1
Alias: Rb-1, pRb, retinoblastoma-associated protein, pp105, retinoblastoma 1
Species: mouse

Top Publications

  1. pmc Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle
    B G Novitch
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 135:441-56. 1996
  2. ncbi Genetic determinants of malignancy in a mouse model for oligodendroglioma
    William A Weiss
    Department of Neurology, University of California, San Francisco, California 94143 0663, USA
    Cancer Res 63:1589-95. 2003
  3. doi shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development
    Christopher A Fasano
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Cell Stem Cell 1:87-99. 2007
  4. pmc Rb regulates fate choice and lineage commitment in vivo
    Eliezer Calo
    David H Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nature 466:1110-4. 2010
  5. pmc Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive
    Courtney H Coschi
    London Regional Cancer Program, University of Western Ontario, London, Ontario, Canada
    Genes Dev 24:1351-63. 2010
  6. ncbi Defining the regulatory networks for muscle development
    J D Molkentin
    Hamon Center for Basic Research in Cancer, University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, 75235 9148, USA
    Curr Opin Genet Dev 6:445-53. 1996
  7. pmc Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions
    J H Dannenberg
    The Netherlands Cancer Institute, Division of Molecular Biology, 1066 CX Amsterdam, The Netherlands
    Genes Dev 14:3051-64. 2000
  8. pmc MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells
    Shipeng Feng
    Lab for RNA Chemical Biology at Guangzhou Institutes of Biomedicine and Health, Chinese Academic of Science, Guangzhou 510530, China
    Nucleic Acids Res 39:6669-78. 2011
  9. pmc Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit
    Alexandre Blais
    Department of Biochemistry, Microbiology, and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa K1H 8M5, Canada
    J Cell Biol 179:1399-412. 2007
  10. ncbi RB status governs differential sensitivity to cytotoxic and molecularly-targeted therapeutic agents
    Kristy R Stengel
    Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Cell Cycle 7:1095-103. 2008

Research Grants

  1. Molecular Mechanisms Regulating Stem Cell Plasticity
    Michael Rudnicki; Fiscal Year: 2004
  2. Parathyroid Hormone Related Protein in the Human Islet
    Rupangi Vasavada; Fiscal Year: 2005
  3. Analysis of transcription in lens using tiled microarrays (ChIP on chip)
    Ales Cvekl; Fiscal Year: 2007
  4. C/EBP alpha in Aging Liver
    Nikolai Timchenko; Fiscal Year: 2009
  5. ID2 IN CELL CYCLE REGULATION AND CANCER
    Antonio Iavarone; Fiscal Year: 2010
  6. Requirements for Normal Rb Function In Vivo
    David W Goodrich; Fiscal Year: 2010
  7. The Role of Thoc1 in Normal Development and Cancer
    David W Goodrich; Fiscal Year: 2011
  8. GENETIC ANALYSIS OF CARDIAC TERMINAL DIFFERENTIATION
    W MacLellan; Fiscal Year: 2003
  9. GENETICS OF A TRANSGENIC MOUSE MODEL FOR NEUROBLASTOMA
    William Weiss; Fiscal Year: 2004
  10. Imaging Kinase Activity In Vivo
    William Weiss; Fiscal Year: 2006

Detail Information

Publications177 found, 100 shown here

  1. pmc Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle
    B G Novitch
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 135:441-56. 1996
    Viral oncoproteins that inactivate the retinoblastoma tumor suppressor protein (pRb) family both block skeletal muscle differentiation and promote cell cycle progression...
  2. ncbi Genetic determinants of malignancy in a mouse model for oligodendroglioma
    William A Weiss
    Department of Neurology, University of California, San Francisco, California 94143 0663, USA
    Cancer Res 63:1589-95. 2003
    ..These models hold promise for studying tumor lineage, identifying contributing genetic alterations and evaluating preclinical therapies in this important neoplasm...
  3. doi shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development
    Christopher A Fasano
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Cell Stem Cell 1:87-99. 2007
    ..Understanding stage-related mechanisms underlying NSC self-renewal has important implications for development of stem cell-based therapies...
  4. pmc Rb regulates fate choice and lineage commitment in vivo
    Eliezer Calo
    David H Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nature 466:1110-4. 2010
    ..Numerous functions have been ascribed to the product of the human RB1 gene, the retinoblastoma protein (pRb)...
  5. pmc Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive
    Courtney H Coschi
    London Regional Cancer Program, University of Western Ontario, London, Ontario, Canada
    Genes Dev 24:1351-63. 2010
    ..In this report, we demonstrate that the retinoblastoma protein (pRB), a well-known regulator of progression through the G1 phase of the cell cycle, plays a critical role in mitotic ..
  6. ncbi Defining the regulatory networks for muscle development
    J D Molkentin
    Hamon Center for Basic Research in Cancer, University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, 75235 9148, USA
    Curr Opin Genet Dev 6:445-53. 1996
    ..Elucidation of these aspects of the myogenic program is leading to a detailed understanding of the regulatory circuits controlling muscle development...
  7. pmc Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions
    J H Dannenberg
    The Netherlands Cancer Institute, Division of Molecular Biology, 1066 CX Amsterdam, The Netherlands
    Genes Dev 14:3051-64. 2000
    The retinoblastoma suppressor pRB belongs to the family of so-called pocket proteins, which also includes p107 and p130. These proteins may functionally overlap in cell cycle control and tumor suppression...
  8. pmc MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells
    Shipeng Feng
    Lab for RNA Chemical Biology at Guangzhou Institutes of Biomedicine and Health, Chinese Academic of Science, Guangzhou 510530, China
    Nucleic Acids Res 39:6669-78. 2011
    ..Further studies showed that retinoblastoma 1 (RB1) is a direct target of miR-192...
  9. pmc Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit
    Alexandre Blais
    Department of Biochemistry, Microbiology, and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa K1H 8M5, Canada
    J Cell Biol 179:1399-412. 2007
    The retinoblastoma tumor suppressor protein (pRb) is involved in mitotic exit, promoting the arrest of myoblasts, and myogenic differentiation. However, it is unclear how permanent cell cycle exit is maintained in differentiated muscle...
  10. ncbi RB status governs differential sensitivity to cytotoxic and molecularly-targeted therapeutic agents
    Kristy R Stengel
    Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Cell Cycle 7:1095-103. 2008
    ..These results indicate that RB status differentially impacts therapeutic response and should be considered when evaluating the efficacy of molecularly targeted therapeutics...
  11. pmc Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family
    Patrick Viatour
    Department of Pediatrics, Stanford Medical School, Stanford, CA 94305, USA
    Cell Stem Cell 3:416-28. 2008
    ..The presence of a single p107 allele is sufficient to largely rescue these defects. Thus, Rb family members collectively maintain HSC quiescence and the balance between lymphoid and myeloid cell fates in the hematopoietic system...
  12. pmc Retinoblastoma loss modulates DNA damage response favoring tumor progression
    Marcos Seoane
    Molecular Oncology Lab, Departamento de Fisioloxia, Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    PLoS ONE 3:e3632. 2008
    ..In this scenario, the absence of pRb confers a proliferative advantage and activates DDR to a greater extent in a DNA lesion-independent fashion than ..
  13. pmc G1 arrest and differentiation can occur independently of Rb family function
    Stacey E Wirt
    Department of Pediatrics, Stanford Medical School, Stanford, CA 94305, USA
    J Cell Biol 191:809-25. 2010
    ....
  14. pmc A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice
    Rebecca Kinkade
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Cancer Res 68:3810-8. 2008
    ..Thus, selective targeting of Rb/Raf-1 interaction seems to be a promising approach for developing novel chemotherapeutic agents...
  15. pmc E2f3a and E2f3b contribute to the control of cell proliferation and mouse development
    Jean Leon Chong
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cell Biol 29:414-24. 2009
    ..Together, we conclude that the contributions of E2F3a and E2F3b in cell proliferation and development are context dependent...
  16. pmc E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells
    Jean Leon Chong
    Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Nature 462:930-4. 2009
    ..This work contextualizes the activator versus repressor functions of E2f1-3 in vivo, revealing distinct roles in dividing versus differentiating cells and in normal versus cancer-like cell cycles...
  17. pmc Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status
    Zhe Jiang
    Division of Cell and Molecular Biology, Toronto General Research Institute University Health Network, Toronto, Ontario, Canada
    J Clin Invest 120:3296-309. 2010
    ..The tumor suppressor gene retinoblastoma 1 (RB1) is frequently lost in both luminal-B and triple-negative tumor (TNT; i.e...
  18. ncbi Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
    Marcos Malumbres
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas CNIO, E 28029 Madrid, Spain
    Cell 118:493-504. 2004
    ..These results indicate that D-type cyclin-dependent kinases are not essential for cell cycle entry and suggest the existence of alternative mechanisms to initiate cell proliferation upon mitogenic stimulation...
  19. pmc Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis
    Zahra Kadri
    CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay aux Roses, France
    PLoS Biol 7:e1000123. 2009
    ..that GATA-1, the master transcription factor of erythropoiesis, forms a tricomplex with the retinoblastoma protein (pRb) and E2F-2...
  20. doi Retinoblastoma 1 protein modulates XY germ cell entry into G1/G0 arrest during fetal development in mice
    Cassy M Spiller
    Division of Molecular Genetics and Development, and Australian Research Council Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Biol Reprod 82:433-43. 2010
    ..5 days postcoitum (dpc). Retinoblastoma 1 (RB1), a potent cell cycle regulator, was investigated in XY germ cell arrest by studying germ cell ..
  21. ncbi pRb is necessary for inhibition of N-myc expression by TGF-beta 1 in embryonic lung organ cultures
    R Serra
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    Development 121:3057-66. 1995
    ..Indirect evidence has indicated that the product of the retinoblastoma gene (pRb) may also be involved in this pathway...
  22. ncbi Chromosomal assignment of retinoblastoma 1 gene (RB1) to mouse 14D3 and rat 15q12 by fluorescence in situ hybridization
    T Ono
    Chromosome Research Unit, Faculty of Science, Hokkaido University, Sapporo, Japan
    Jpn J Genet 68:617-21. 1993
    The retinoblastoma 1 gene was assigned to mouse chromosome 14 at band D3 and rat chromosome 15 at band q12, respectively, by fluorescence in situ hybridization (FISH)...
  23. ncbi The proliferative and apoptotic activities of E2F1 in the mouse retina
    S C Lin
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio, Texas, TX 78245 3207, USA
    Oncogene 20:7073-84. 2001
    ..Our findings support the concept that cross-talk occurs between different retinal cell types and that multiple genetic pathways must become dysregulated for the full oncogenic transformation of neuronal retinal cells...
  24. ncbi Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo
    Joshua L Dunaief
    FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Eye Res 24:392-6. 2002
    To identify and characterize retinoblastoma protein (pRb) binding proteins that may influence retinoblast proliferation and retinal pigment epithelial cell survival.
  25. ncbi Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin
    Susana Gonzalo
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre CNIO, Madrid E 28029, Spain
    Nat Cell Biol 7:420-8. 2005
    ..Mouse embryonic fibroblasts that are triply deficient for RB1 (retinoblastoma 1), RBL1 (retinoblastoma-like 1) and RBL2 (retinoblastoma-like 2) - known as TKO cells - show a marked genomic ..
  26. pmc A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development
    Sarah M Francis
    London Regional Cancer Program, University of Western Ontario, London, Ontario N6A4L6, Canada
    Mol Cell Biol 29:4455-66. 2009
    ..been shown to inhibit cyclin-dependent kinase (CDK) activity, which leads to the accumulation of hypophosphorylated pRB. However, unlike other components of TGF-beta cytostatic signaling, pRB is thought to be dispensable for mammary ..
  27. pmc Rb and N-ras function together to control differentiation in the mouse
    Chiaki Takahashi
    Department of Medical Oncology and Medicine, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 23:5256-68. 2003
    ..Previous cell culture-based experiments have suggested that the retinoblastoma protein (pRb) and Ras operate in a common pathway to control cellular differentiation...
  28. ncbi The retinoblastoma gene family in differentiation and development
    M M Lipinski
    Department of Biology, Massachusetts Institute of Technology, Center for Cancer Research, Cambridge 02139, USA
    Oncogene 18:7873-82. 1999
    ..They also play a critical role in assuring the orderly progression through all these stages of differentiation...
  29. pmc Regulation of RB transcription in vivo by RB family members
    Deborah L Burkhart
    Department of Pediatrics, Stanford Medical School, 269 Campus Drive, CCSR1215, Stanford, CA 94305, USA
    Mol Cell Biol 30:1729-45. 2010
    ..These experiments identify novel regulatory feedback mechanisms within the RB pathway in mammalian cells...
  30. ncbi Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer
    Zongxiang Zhou
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853 6401, USA
    Cancer Res 66:7889-98. 2006
    ..The new genetically defined model should be particularly valuable for providing new molecular insights into the pathogenesis of human prostate cancer...
  31. pmc A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence
    Srikanth Talluri
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Mol Cell Biol 30:948-60. 2010
    ..Here we show that the retinoblastoma protein (pRB) uses a mechanism to block DNA replication in senescence that is distinct from its role in permanent cell cycle ..
  32. pmc A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation
    Brett R Johnson
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:9677-82. 2004
    The retinoblastoma protein (pRB) is a critical regulator of cell proliferation and differentiation and an important tumor suppressor...
  33. pmc The Rb tumor suppressor is required for stress erythropoiesis
    Benjamin T Spike
    The Ben May Institute for Cancer Research, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    EMBO J 23:4319-29. 2004
    ..Early studies using gene targeting in mice suggested a critical role for pRb in erythropoiesis, while more recent experiments have suggested that many of the abnormal embryonic phenotypes in ..
  34. pmc Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs
    H te Riele
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
    Proc Natl Acad Sci U S A 89:5128-32. 1992
    ..This result indicates that, also in mammalian cells, homologous recombination rather than random integration can be the predominant event...
  35. ncbi Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs
    P L Chen
    Institute of Biotechnology, The University of Texas Health Science Center at San Antonio 78245, USA
    Genes Dev 10:2794-804. 1996
    ..Such a role contrasts with the function of Rb in arresting cell cycle progression in G1 by negative regulation of other transcription factors like E2F-1...
  36. ncbi pRb and E2f-1 in mouse development and tumorigenesis
    K Macleod
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK
    Curr Opin Genet Dev 9:31-9. 1999
    ..E2F-1 can induce both apoptosis and S-phase transition and whether E2F-1 acts as an oncogene or a tumor-suppressor gene may depend on the extent to which E2F-1 induces apoptosis as opposed to G1/S transition...
  37. ncbi Retinoblastoma gene promoter directs transgene expression exclusively to the nervous system
    Z Jiang
    Department of Medicine, University of Toronto and Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada M5G 2MI
    J Biol Chem 276:593-600. 2001
    ....
  38. ncbi Cutting edge: differential signaling requirements for activation of assembled cyclin D3-cdk4 complexes in B-1 and B-2 lymphocyte subsets
    D A Tanguay
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    J Immunol 166:4273-7. 2001
    ..Although cyclin D2-cyclin-dependent kinase 4 (cdk4) complexes mediate early retinoblastoma gene product (pRb) phosphorylation in B-1 cells, the transient nature of their accumulation cannot account for the continued increase ..
  39. ncbi Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ducts
    Zongxiang Zhou
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853 6401, USA
    Cancer Res 67:5683-90. 2007
    ..These findings indicate that p53 and Rb are critically important for the regulation of the prostatic stem cell compartment, the transformation in which may lead to particularly aggressive cancers in the context of microenvironment...
  40. pmc Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage
    Seth D Berman
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:11851-6. 2008
    ..Finally, we show that loss of Rb and p53 in Sca-1-positive mesenchymal stem/progenitor cells is sufficient to yield transformed cells that can initiate osteosarcoma formation in vivo...
  41. doi AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and glucose deprivation by down-regulating phospho-retinoblastoma protein and cyclin D
    Yi Zang
    National Center for Drug Screening and Neurological Pharmacology Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    J Biol Chem 284:6175-84. 2009
    ..AMPK, but not JAK/STAT3, activation is key for this inhibitory effect and may play an important role in the responses of NSCs to metabolic stresses such as glucose deprivation...
  42. pmc Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle
    Kostandin V Pajcini
    Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stem Cell 7:198-213. 2010
    ..These results show that differentiation of mammalian cells is reversed by inactivation of Arf and Rb and support the hypothesis that Arf evolved at the expense of regeneration...
  43. ncbi Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance
    N Hu
    Center for Molecular Medicine Institute of Biotechnology, University of Texas, San Antonio 78284
    Oncogene 9:1021-7. 1994
    ..The Rb knock out mouse strain provides a unique model for addressing tissue-specific tumor predisposition by inactivation of a ubiquitously expressed tumor suppressor gene...
  44. ncbi pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis
    E Zacksenhaus
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Genes Dev 10:3051-64. 1996
    ..We have generated transgenic mice (RBlox) that express low levels of pRb, driven by an RB1 minigene...
  45. pmc p107 is a suppressor of retinoblastoma development in pRb-deficient mice
    E Robanus-Maandag
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Genes Dev 12:1599-609. 1998
    ..In the mouse, however, Rb hemizygosity leaves the retina normal, whereas in Rb-/- chimeras pRb-deficient retinoblasts undergo apoptosis...
  46. ncbi The retinoblastoma gene family: cousins with overlapping interests
    G Mulligan
    Center for Cancer Research, Howard Hughes Medical Institute, Cambridge, MA, USA
    Trends Genet 14:223-9. 1998
    The retinoblastoma tumor suppressor gene (RB1) and its relatives, p107 and p130, encode a family of proteins that share several properties, including the capacity to regulate E2F-dependent transcription and inhibit cell-cycle progression...
  47. pmc Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
    S Marino
    Division of Molecular Genetics and Centre of Biomedical Genetics, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands
    Genes Dev 14:994-1004. 2000
    ..Our results demonstrate that loss of function of RB is essential for medulloblastoma development in the mouse and strongly support the hypothesis that medulloblastomas arise from multipotent precursor cells located in the EGL...
  48. ncbi Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
    A Lasorella
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 407:592-8. 2000
    ..Thus, a dual connection links Id2 and Rb: during normal cell-cycle, Rb prohibits the action of Id2 on its natural targets, but oncogenic activation of the Myc-Id2 transcriptional pathway overrides the tumour-suppressor function of Rb...
  49. ncbi E2F1 and p53 are dispensable, whereas p21(Waf1/Cip1) cooperates with Rb to restrict endoreduplication and apoptosis during skeletal myogenesis
    Z Jiang
    Department of Medicine, Toronto General Hospital Research Institute, University Health Network, University of Toronto, 67 College Street, Toronto, Ontario, Canada
    Dev Biol 227:8-41. 2000
    ..Thus, combined inactivation of Rb and p21(Waf1/Cip1) augments endoreduplication and apoptosis, whereas E2F1 and p53 are dispensable during aberrant myogenesis in Rb-deficient fetuses...
  50. pmc TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1
    S I Hsu
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    EMBO J 20:2273-85. 2001
    ....
  51. pmc Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma
    Zhe Jiang
    Department of Medicine, University of Toronto, Ontario, Canada M5G 2M1
    J Cell Biol 156:185-98. 2002
    ....
  52. ncbi Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member
    Shyng Shiou F Yuan
    Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, ROC
    Biochem Biophys Res Commun 296:1019-25. 2002
    ..In summary, the ubiquitous tumor suppressor RB and the neuron-enriched transcription factor Pax-2 may play a role in the regulation of Rig-1 expression during embryogenesis...
  53. ncbi Extra-embryonic function of Rb is essential for embryonic development and viability
    Lizhao Wu
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Nature 421:942-7. 2003
    ....
  54. ncbi Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growth
    Hong Xin
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Building No 1, Mail Code 114B, Maywood, IL 60153, USA
    Oncogene 22:4775-85. 2003
    ..Together, our observations support the idea that the transcriptional activation of Ifi202 gene by Rb/JunD may be important for the regulation of cell growth and survival...
  55. ncbi Rb regulates proliferation and rod photoreceptor development in the mouse retina
    Jiakun Zhang
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Genet 36:351-60. 2004
    ..a cell-autonomous manner, we used a replication-incompetent retrovirus encoding Cre recombinase to inactivate the Rb1(lox) allele in individual retinal progenitor cells in vivo...
  56. ncbi Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis
    Sergio Ruiz
    Department of Cell and Molecular Biology and Gene Therapy, CIEMAT, Madrid E28040, Spain
    Development 131:2737-48. 2004
    The retinoblastoma gene product, pRb, plays a crucial role in cell cycle regulation, differentiation and inhibition of oncogenic transformation...
  57. pmc Cell type-specific effects of Rb deletion in the murine retina
    David MacPherson
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 18:1681-94. 2004
    ..Conditional Rb mutation in the retina did not result in retinoblastoma formation even in a p53-mutant background. However, on a p107- or p130-deficient background, Rb mutation in the retina caused retinal dysplasia or retinoblastoma...
  58. pmc A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cells
    Grazia Camarda
    Depatment of Environment and Primary Prevention, Higher Institute of Health, 00161 Roma, Italy
    J Cell Biol 167:417-23. 2004
    In skeletal muscle differentiation, the retinoblastoma protein (pRb) is absolutely necessary to establish definitive mitotic arrest...
  59. ncbi Developmental defects in Rb-deficient retinae
    Stacy L Donovan
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Vision Res 44:3323-33. 2004
    ..Therefore, the retinae from Chx10-Cre;RbLox/- mice represent a unique model to study the role of rod photoreceptor inputs in horizontal cell differentiation and synapse formation...
  60. ncbi Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis
    Oriol Casanovas
    Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California San Francisco, 94143, USA
    Oncogene 24:6597-604. 2005
    ....
  61. ncbi Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha
    Anthony Scime
    Molecular Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Cell Metab 2:283-95. 2005
    ..mice contained markedly elevated numbers of adipogenic precursors that displayed downregulated expression of pRb. Consistent with the hypothesis that pRb is required for adult adipocyte differentiation, Cre-mediated deletion of ..
  62. ncbi Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function
    M P Markey
    Department of Cell and Cancer Biology, University of Cincinnati, Cincinnati, OH 45267 0521, USA
    Oncogene 26:6307-18. 2007
    ....
  63. pmc Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice
    Gabriel M Gutierrez
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 105:18402-7. 2008
    ..We now show that pRb also plays a role early in osteogenesis, and that in primary RB1(-/-) calvarial cells there is an increased osteoprogenitor pool...
  64. pmc Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects
    Seth D Berman
    David H Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:14932-6. 2009
    The retinoblastoma tumor-suppressor protein, pRb, is a member of the pocket protein family that includes p107 and p130...
  65. pmc Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells
    Roopa L Nalam
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 23:1900-13. 2009
    ..Our results demonstrate that RB is essential for proper terminal differentiation of Sertoli cells...
  66. pmc E2F-1 has dual roles depending on the cell cycle
    Fikret Sahin
    Department of Microbiology and Immunology, Finch University of Health Sciences Chicago Medical School now Rosalind Franklin University, 3333 Green Bay Road, North Chicago, Illinois 60064 3095, USA
    Int J Biol Sci 6:116-28. 2010
    ..E2F-1 is the major cellular target of pRB and is regulated by pRB during cell proliferation...
  67. pmc E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas
    Ulrike Ziebold
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell Biol 23:6542-52. 2003
    The E2F transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor...
  68. ncbi Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
    E Y Lee
    Center for Molecular Medicine, University of Texas Health Science Center, San Antonio 78284
    Nature 359:288-94. 1992
    ..All spinal ganglion cells die, but the neural retina is unaffected. Transfer of the human retinoblastoma (RB) mini-transgene into the mutant mice corrects the developmental defects. Thus, Rb is essential for normal mouse development...
  69. ncbi Requirement for a functional Rb-1 gene in murine development
    A R Clarke
    Department of Pathology, University of Edinburgh, UK
    Nature 359:328-30. 1992
    ..However, homozygous mutant embryos fail to reach term and show a number of abnormalities in neural and haematopoietic development. Broadly similar results are reported by the other groups...
  70. pmc Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis
    A Almasan
    Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 92:5436-40. 1995
    ....
  71. pmc Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice
    E C Maandag
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
    EMBO J 13:4260-8. 1994
    ..Moreover, the formation of lens fibre cells was severely disturbed. No retinoblastomas developed in any of these mice. Instead, nearly all animals died of pituitary gland tumours which were exclusively derived from Rb-1- cells...
  72. ncbi Cooperative tumorigenic effects of germline mutations in Rb and p53
    B O Williams
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Nat Genet 7:480-4. 1994
    ..These data indicate that mutations in Rb and p53 can cooperate in the transformation of certain cell types in the mouse...
  73. ncbi p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    S D Morgenbesser
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461
    Nature 371:72-4. 1994
    ..This developmental system provides a framework for understanding the consequences of the frequent mutation of both RB and p53 in human cancer...
  74. ncbi Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts
    P Savatier
    Laboratoire de Biologie Moleculaire et Cellulaire, CNRS UM R49, INRA, Ecole Normale Superieure de Lyon, France
    Oncogene 9:809-18. 1994
    ..Absence of hypophosphorylated RB and cell cycle-dependent change in total RB protein level may be relevant to the high proliferation rate and to the tumorigenic nature of mouse embryonic stem cells...
  75. ncbi Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells
    J W Schneider
    Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, MA 02115
    Science 264:1467-71. 1994
    ..Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb-/- myotubes...
  76. ncbi Targeted disruption of p107: functional overlap between p107 and Rb
    M H Lee
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Genes Dev 10:1621-32. 1996
    ..These results provide the first in vivo evidence that p107 and Rb have overlapping functions in some tissues of the developing and adult mouse...
  77. pmc Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
    K F Macleod
    Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    EMBO J 15:6178-88. 1996
    ..Although loss of p53 gene function prevents cell death in the CNS of Rb-mutant embryos, it does not restore normal proliferative control...
  78. ncbi The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis
    S Herwig
    Max Planck Gesellschaft, Humboldt Universitat, Max Delbrück Centrum for Molecular Medicine, Berlin Buch, Germany
    Eur J Biochem 246:581-601. 1997
    The retinoblastoma susceptibility gene is a tumour suppressor and its product retinoblastoma protein (pRb) has been known for 10 years as a repressor of progression towards S phase...
  79. ncbi Retinoblastoma protein represses transcription by recruiting a histone deacetylase
    L Magnaghi-Jaulin
    Laboratoire Oncogenese, Differenciation et Transduction du Signal, CNRS UPR 9079, Villejuif, France
    Nature 391:601-5. 1998
    ..Our results strongly suggest that the Rb/HDAC1 complex is a key element in the control of cell proliferation and differentiation and that it is a likely target for transforming viruses...
  80. pmc A critical temporal requirement for the retinoblastoma protein family during neuronal determination
    R S Slack
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Canada H3A 2B4
    J Cell Biol 140:1497-509. 1998
    ..To determine whether pRb is required for neuronal determination in vivo, we crossed the Rb-/- mice with transgenic mice expressing beta-..
  81. ncbi pRB is required for interferon-gamma-induction of the MHC class II abeta gene
    X Zhu
    Eye Research Institute for Canada, 399 Bathurst Street, Toronto, Ontario, Canada, M5T 2S8
    Oncogene 18:4940-7. 1999
    b>pRB is required for IFN-gamma-induction of MHC class II in human tumor cell lines, providing a potential link between tumor suppressors and the immune system...
  82. ncbi The Rb-CDK4/6 signaling pathway is critical in neural precursor cell cycle regulation
    K L Ferguson
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 275:33593-600. 2000
    ..Furthermore, our data underscore the importance of the Rb regulatory pathway in neuronal development and cell cycle regulation, independent of CKI sequestration...
  83. pmc Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization
    J Sage
    Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 14:3037-50. 2000
    The retinoblastoma protein, pRB, and the closely related proteins p107 and p130 are important regulators of the mammalian cell cycle...
  84. pmc E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos
    U Ziebold
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 15:386-91. 2001
    The E2F transcription factors are thought to be key downstream targets of the retinoblastoma protein (pRB) tumor suppressor...
  85. ncbi The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation
    D M Thomas
    Department of Pathology and, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 8:303-16. 2001
    ..To understand why the retinoblastoma protein (pRb) is specifically targeted in osteosarcoma, we studied its function in osteogenesis...
  86. ncbi Functional mammary gland development and oncogene-induced tumor formation are not affected by the absence of the retinoblastoma gene
    G W Robinson
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
    Oncogene 20:7115-9. 2001
    ..We investigated the consequences of the absence of pRb in mammary epithelial cells during normal development and in mice that express an oncogene in the mammary ..
  87. ncbi Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb
    Harold I Saavedra
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics and Department of Molecular Genetics, The Ohio State University, Columbus 43210, USA
    Cell Growth Differ 13:215-25. 2002
    ..These results provide clear evidence for functional specificity among E2Fs in the control of Rb-dependent proliferation and apoptosis in a tissue-specific manner...
  88. ncbi Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells
    Marc Vooijs
    Division of Molecular Genetics, The Netherlands Cancer Institute Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Oncogene 21:4635-45. 2002
    ..Our results highlight the important differences that exist in tumor susceptibility between mice and man (e.g pineal gland) and question the photoreceptor cell origin of human retinoblastoma...
  89. ncbi Loss of Rb overrides the requirement for ERK activity for cell proliferation
    Giovanna M D'Abaco
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    J Cell Sci 115:4607-16. 2002
    ..Analysis of Rb-deficient tumour cell lines also revealed a reduced requirement for ERK signalling in asynchronous growth. We discuss the molecular mechanism that may underlie this escape from MAP kinase signalling...
  90. ncbi E2F4 loss suppresses tumorigenesis in Rb mutant mice
    Eunice Y Lee
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Cell 2:463-72. 2002
    ..the activation or repression of key cell cycle regulatory genes under the control of the retinoblastoma protein (pRB) tumor suppressor and its relatives, p107 and p130...
  91. pmc Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice
    Alain de Bruin
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus 43210, USA
    Proc Natl Acad Sci U S A 100:6546-51. 2003
    ....
  92. ncbi Distinct gene expression phenotypes of cells lacking Rb and Rb family members
    Esther P Black
    Department of Molecular Genetics and Microbiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 63:3716-23. 2003
    ..We suggest that this is an approach to the eventual understanding of gene regulatory pathways that define a phenotypic state, including those events that lead to tumor development...
  93. ncbi Differential regulation of apoptotic genes by Rb in human versus mouse cells
    Arthur P Young
    Department of Medicine, Washington University School of Medicine, 4940 Parkview Place, St Louis, MO 63110, USA
    Oncogene 23:2587-99. 2004
    ....
  94. ncbi Geminin is targeted for repression by the retinoblastoma tumor suppressor pathway through intragenic E2F sites
    Michael Markey
    Department of Cell Biology, University of Cincinnati, Vontz Center for Molecular Studies, Cincinnati, Ohio 45267 0521, USA
    J Biol Chem 279:29255-62. 2004
    ..Together, these data link the expression of geminin to the RB/E2F pathway and represent the first promoter analysis of this important regulator of DNA replication...
  95. ncbi Cell-intrinsic requirement for pRb in erythropoiesis
    Allison J Clark
    Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria 8006, Australia
    Blood 104:1324-6. 2004
    ..In particular, accumulated data have suggested that the Rb gene product pRb is an important controller of erythroid differentiation...
  96. ncbi Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma
    Danian Chen
    Toronto Western Research Institute, University Health Network, Vision Science Research Program, Department of Ophthalmology and Visual Sciences, University of Toronto, 399 Bathurst Street, Toronto, Ontario, Canada, M5T 2S8
    Cancer Cell 5:539-51. 2004
    ..We suggest that additional lesions common in retinoblastoma overcome growth arrest, not apoptosis...
  97. pmc Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation
    Michael S Huh
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada, K1H 8L6
    J Cell Biol 166:865-76. 2004
    To investigate the requirement for pRb in myogenic differentiation, a floxed Rb allele was deleted either in proliferating myoblasts or after differentiation...
  98. ncbi Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
    Antonio Iavarone
    Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nature 432:1040-5. 2004
    ..1, a master regulator of macrophage differentiation. Thus, Rb has a cell autonomous function in fetal liver macrophages, and restrains Id2 in these cells in order to implement definitive erythropoiesis...
  99. pmc Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb
    W R MacLellan
    Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, 675 C E Young Dr, MRL 3 645, Los Angeles, CA 90095 1760, USA
    Mol Cell Biol 25:2486-97. 2005
    ..Thus, Rb and p130 have overlapping functional roles in vivo to suppress cell cycle activators, including Myc, and maintain quiescence in postnatal cardiac muscle...
  100. pmc Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice
    Anna Lasorella
    Institute for Cancer Genetics, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Mol Cell Biol 25:3563-74. 2005
    ..In human neuroblastoma, the N-Myc-driven expression of Id2 is sufficient and necessary for expression of VEGF. These results establish that aberrant Id2 activity directs initiation and progression of embryonal cancer...
  101. pmc The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
    Johanna Mantela
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 132:2377-88. 2005
    ..We show here that the retinoblastoma gene Rb and the encoded protein pRb are expressed in differentiating and mature hair cells...

Research Grants11

  1. Molecular Mechanisms Regulating Stem Cell Plasticity
    Michael Rudnicki; Fiscal Year: 2004
    ..To investigate the mechanism by which Pax7 enforces lineage commitment, FACS/Hoechst enriched adult stem cells from Pax7-/- mice will be transplanted either intravenously or intramuscularly. ..
  2. Parathyroid Hormone Related Protein in the Human Islet
    Rupangi Vasavada; Fiscal Year: 2005
    ..Studies of this nature would be a critical first step towards reducing the number of islets required for successful transplantation. ..
  3. Analysis of transcription in lens using tiled microarrays (ChIP on chip)
    Ales Cvekl; Fiscal Year: 2007
    ..5 key transcription factors regulating lens lineage formation, Pax6 and Sox2, and differentiation (c-Maf, Proxl and pRb) with nearly 100 genes/loci encoding proteins essential for lens development and homeostasis; and (2) Identify ..
  4. C/EBP alpha in Aging Liver
    Nikolai Timchenko; Fiscal Year: 2009
    ..Based on data obtained in this project, we are planning to start developing a strategy to correct liver proliferation in elderly. ..
  5. ID2 IN CELL CYCLE REGULATION AND CANCER
    Antonio Iavarone; Fiscal Year: 2010
    ..The proposed work will define the mechanisms underlying regulation of Id2 and enhance our understanding of the involvement of uncontrolled Id2 activity in human cancer. ..
  6. Requirements for Normal Rb Function In Vivo
    David W Goodrich; Fiscal Year: 2010
    ..Rb1 protein (pRb) is a negative regulator of the cell cycle, and this cell cycle regulatory activity contributes to tumor ..
  7. The Role of Thoc1 in Normal Development and Cancer
    David W Goodrich; Fiscal Year: 2011
    ..The experiments proposed will determine whether pThod is a promising target for the development of new therapies and prognostic tests. ..
  8. GENETIC ANALYSIS OF CARDIAC TERMINAL DIFFERENTIATION
    W MacLellan; Fiscal Year: 2003
    ..This first RO1 proposes to further define the role of PRI-1 in cardiac myocyte differentiation and elucidate its biochemical properties. ..
  9. GENETICS OF A TRANSGENIC MOUSE MODEL FOR NEUROBLASTOMA
    William Weiss; Fiscal Year: 2004
    ..Given the poor outcome associated with childhood neuroblastoma, this work has the potential to increase our understanding of the pathogenesis of neuroblastoma, and may result in improved therapies for children with this disorder. ..
  10. Imaging Kinase Activity In Vivo
    William Weiss; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  11. Lactogens and Pancreatic Beta Cell Survival
    Rupangi Vasavada; Fiscal Year: 2009
    ..abstract_text> ..