Rnf135

Summary

Gene Symbol: Rnf135
Description: ring finger protein 135
Alias: 0610037N03Rik, 2410006N06Rik, E3 ubiquitin-protein ligase RNF135, RING-type E3 ubiquitin transferase RNF135, Riplet
Species: mouse

Top Publications

  1. doi The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku Sapporo 060 8638, Japan
    Cell Host Microbe 8:496-509. 2010
  2. pmc Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein
    Ricardo Rajsbaum
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Pathog 8:e1003059. 2012
  3. pmc A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    PLoS Pathog 9:e1003533. 2013
  4. ncbi Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT)
    Seok Hong Min
    Interdisciplinary Concentration in Animal Molecular and Cell Biology, Genetics Institute, and Department of Animal Sciences, University of Florida, Gainesville, Florida 32611 0910, USA
    J Biol Chem 277:3647-57. 2002
  5. ncbi Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse
    Dieter E Jenne
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    Genes Chromosomes Cancer 37:111-20. 2003
  6. ncbi Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval
    M Venturin
    Department of Biology and Genetics, Medical Faculty University of Milan, Italy
    Ann Hum Genet 69:508-16. 2005

Scientific Experts

  • Hiroyuki Oshiumi
  • Ricardo Rajsbaum
  • M Venturin
  • Dieter E Jenne
  • Seok Hong Min
  • Michaela U Gack
  • Estanislao Nistal-Vill├ín
  • Gijs A Versteeg
  • Randy A Albrecht
  • Natalya P Maharaj
  • May K Wang
  • Adolfo Garcia-Sastre
  • P Riva
  • L Larizza
  • A Bentivegna
  • R Moroni
  • Horst Hameister
  • Karen Stephens
  • Michael O Dorschner
  • Hildegard Kehrer-Sawatzki
  • Sigrid Tinschert
  • Maria Halmekyto
  • Carl W Porter
  • Frank A Simmen
  • Rosalia C M Simmen
  • Leena Alhonen
  • Juhani Janne

Detail Information

Publications6

  1. doi The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku Sapporo 060 8638, Japan
    Cell Host Microbe 8:496-509. 2010
    ..RIG-I is regulated by Lys63-linked polyubiquitination, and three E3 ubiquitin ligases, RNF125, TRIM25, and Riplet, are reported to target RIG-I for ubiquitination...
  2. pmc Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein
    Ricardo Rajsbaum
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Pathog 8:e1003059. 2012
    ..Therefore, we tested if the ubiquitin E3 ligase Riplet, which has also been shown to ubiquitinate RIG-I, interacts with NS1...
  3. pmc A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    PLoS Pathog 9:e1003533. 2013
    ..RIG-I activation is regulated by the K63-linked polyubiquitin chain mediated by Riplet and TRIM25 ubiquitin ligases...
  4. ncbi Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT)
    Seok Hong Min
    Interdisciplinary Concentration in Animal Molecular and Cell Biology, Genetics Institute, and Department of Animal Sciences, University of Florida, Gainesville, Florida 32611 0910, USA
    J Biol Chem 277:3647-57. 2002
    ..The data suggest that SSAT and polyamines are important for the control of molecular pathways underlying reproductive tract tissue growth, phenotype, and function...
  5. ncbi Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse
    Dieter E Jenne
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    Genes Chromosomes Cancer 37:111-20. 2003
    ....
  6. ncbi Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval
    M Venturin
    Department of Biology and Genetics, Medical Faculty University of Milan, Italy
    Ann Hum Genet 69:508-16. 2005
    ....