Genomes and Genes
Gene Symbol: T
Alias: Bra, D17Mit170, Low, Tl2, Tl3, cou, me75, brachyury protein, brachyury-like 2, brachyury-like 3, low ratio, protein T
Publications168 found, 100 shown here
- Cloning of the T gene required in mesoderm formation in the mouseB G Herrmann
Laboratory of Molecular Embryology, National Institute for Medical Research, London, UK
Nature 343:617-22. 1990The murine developmental mutation T identifies an essential gene in mesoderm formation. Embryos lacking normal gene activity fail to form the notochord, the entire posterior region and the allantois, and die at about 10 days of gestation...
- The T genes in embryogenesisB G Herrmann
Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Germany
Trends Genet 10:280-6. 1994Since its identification in 1927, the mouse T (Brachyury) locus has been implicated in mesoderm formation and notochord differentiation...
- The T protein encoded by Brachyury is a tissue-specific transcription factorA Kispert
Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Germany
EMBO J 14:4763-72. 1995The mouse Brachyury (T) gene is required for differentiation of the notochord and formation of mesoderm during posterior development. Homozygous embryos lacking T activity do not develop a trunk and tail and die in utero...
- Murine FGFR-1 is required for early postimplantation growth and axial organizationC X Deng
Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
Genes Dev 8:3045-57. 1994..Such abnormalities are unlikely to be caused by intrinsic blocks in mesodermal differentiation, as FGFR-1-deficient ES cell lines form teratomas consisting of many mesodermal cell types...
- Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryoAdam H Hart
The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, VIC 3050, Australia
Development 129:3597-608. 2002..Mixl1 is therefore required for the morphogenesis of axial mesoderm, the heart and the gut during embryogenesis...
- Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarityJen Chih Hsieh
Department of Biochemistry and Cell Biology, Center for Developmental Genetics, State University of New York, Stony Brook, Stony Brook, NY 11794, USA
Cell 112:355-67. 2003..between mesd-deficient and wnt3(-)(/)(-) embryos suggest that MESD may function on related members of the low-density lipoprotein receptor (LDLR) family, whose members mediate diverse cellular processes ranging from cargo ..
- T-box genes in early embryogenesisChris Showell
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Dev Dyn 229:201-18. 2004The T-box gene family, encoding related DNA-binding transcriptional regulators, plays an essential role in controlling many aspects of embryogenesis in a wide variety of organisms...
- Brachyury proteins regulate target genes through modular binding sites in a cooperative fashionThomas Kusch
Institut fur Genetik, Universitat zu Koln, 50931 Koln, Germany
Genes Dev 16:518-29. 2002Brachyury proteins, a conserved subgroup of the T domain transcription factors, specify gut and posterior mesoderm derivatives throughout the animal kingdom...
- Expression pattern of the mouse T gene and its role in mesoderm formationD G Wilkinson
Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, UK
Nature 343:657-9. 1990..Genetic evidence indicates that in the mouse the T gene (Brachyury) has a role in the formation and organization of mesoderm...
- Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulationD Acampora
International Institute of Genetics and Biophysics CNR, Naples, Italy
Development 121:3279-90. 1995....
- Alterations in gene expression during mesoderm formation and axial patterning in Brachyury (T) embryosP Rashbass
National Institute for Medical Research, London, United Kingdom
Int J Dev Biol 38:35-44. 1994The mouse T (Brachyury) deletion causes defective mesoderm formation and notochord morphogenesis, and abnormalities in the caudal neural tube and somites...
- Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryosW S Chen
Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021
Genes Dev 8:2466-77. 1994..Development of embryonic structures is severely impaired. These results demonstrate that the expression of HNF-4 in the visceral endoderm is essential for embryonic ectoderm survival and normal gastrulation...
- Mutation watch: mouse brachyury (T), the T-box gene family, and human diseaseM H Meisler
Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
Mamm Genome 8:799-800. 1997
- The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structuresS Abu-Abed
Cancer Research Labs, Queen s University, Kingston, Ontario, K7L 3N6, Canada
Genes Dev 15:226-40. 2001....
- Induction of the mammalian node requires Arkadia function in the extraembryonic lineagesV Episkopou
Mammalian Neurogenesis, MRC Clinical Science Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Nature 410:825-30. 2001..Furthermore, our experiments show that Arkadia interacts genetically with the transforming growth factor (TGF)beta-like factor Nodal, implying that Nodal mediates the function of Arkadia in node induction...
- α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in miceAmparo Girós
Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Burjassot, Spain
PLoS ONE 6:e22002. 2011..Thus, α5β1-mediated adhesion to FN in the PSM regulates the dynamics of membrane protrusions and cell-to-cell communication essential for elongation and segmentation of the body axis...
- Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: implications for evolution of the vertebrate discBradley J Bruggeman
Department of Molecular Genetics and Microbiology, Genetics Institute, University of Florida, College of Medicine, Gainesville, Florida, USA
Dev Dyn 241:675-83. 2012..A histological analysis of mammalian and nonmammalian organisms suggests that nuclei pulposi are only present in mammals...
- Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulationD Acampora
International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
Development 125:5091-104. 1998..Moreover, our data lead us to hypothesize that the differential post-transcriptional control existing between VE and epiblast cells may potentially contribute to fundamental regulatory mechanisms required for head specification...
- Genetic dissection of nodal function in patterning the mouse embryoL A Lowe
Experimental Immunology Branch, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Development 128:1831-43. 2001..We find that nodal signaling is required for correct positioning of the anteroposterior axis, normal anterior and midline patterning, and the left-right asymmetric development of the heart, vasculature, lungs and stomach...
- Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantoisL A Naiche
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 W 168th Street, New York, NY 10032, USA
Development 130:2681-93. 2003Tbx4 is a member of the T-box family of transcription factor genes, which have been shown to play important roles in development. We have ablated Tbx4 function using targeted mutagenesis in the mouse...
- The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in miceOlivia G Kelly
Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3200, USA
Development 131:2803-15. 2004..The effect of reducing, but not eliminating, Wnt signaling in Lrp5(+/-);Lrp6(-/-) mutant embryos provides important insight into the interplay between Wnt, Fgf and Nodal signals in patterning the early mouse embryo...
- Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survivalAtsushi Sawada
Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
Mol Cell Biol 28:3177-89. 2008..These results suggest that Tead1 and Tead2 are functionally redundant, use YAP as a major coactivator, and support notochord maintenance as well as cell proliferation and survival in mouse development...
- The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryoD C Weinstein
Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021
Cell 78:575-88. 1994..Endodermal cells are present but fail to form a gut tube in mutant embryos. These studies indicate that HNF-3 beta has an essential role in the development of axial mesoderm in mouse embryos...
- Brachyury--a gene affecting mouse gastrulation and early organogenesisR S Beddington
Centre for Genome Research, Edinburgh, UK
Dev Suppl . 1992Mouse embryos that are homozygous for the Brachyury (T) deletion die at mid-gestation. They have prominent defects in the notochord, the allantois and the primitive streak...
- The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulationV Wilson
Laboratory of Mammalian Development, National Institute for Medical Research, London, UK
Development 121:877-86. 1995The T (Brachyury) deletion in mouse is responsible for defective primitive streak and notochord morphogenesis, leading to a failure of the axis to elongate properly posterior to the forelimb bud...
- Wnt-3a regulates somite and tailbud formation in the mouse embryoS Takada
Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
Genes Dev 8:174-89. 1994..We suggest that dysmorphology is secondary to the mesodermal and axial defects and that dorsal patterning of the CNS may be regulated by inductive signals arising from surface ectoderm...
- Expression of T protein in the primitive streak is necessary and sufficient for posterior mesoderm movement and somite differentiationV Wilson
Human Genetics Unit, MMC, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom
Dev Biol 192:45-58. 1997A characteristic abnormality of chimeras composed of wildtype and T/T (Brachyury) mutant embryonic stem cells is the aggregation and accumulation of mutant cells in the primitive streak and its descendant, the tail bud (V. Wilson, L...
- The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryoDominic P Norris
Department of Molecular and Cellular Biology, Harvard University, The Biological Laboratories, Cambridge, MA 02138, USA
Development 129:3455-68. 2002..The feedback loop is thus essential for maintenance of Nodal signals that selectively regulate target gene expression in a temporally and spatially controlled fashion in the mouse embryo...
- Inheritance of T-associated sex reversal in miceL L Washburn
Jackson Laboratory, Bar Harbor, Maine 04609
Genet Res 56:185-91. 1990..This newly identified gene may be one of the previously defined loci, tda-1 or tda-2...
- A role for Pax-1 as a mediator of notochordal signals during the dorsoventral specification of vertebraeH Koseki
Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
Development 119:649-60. 1993..abnormalities in Sd coincide closely, both in time and space, with notochordal changes, as determined by whole-mount T antibody staining...
- Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesisY Mishina
Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
Genes Dev 9:3027-37. 1995....
- Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryoE Hermesz
Laboratory of Mammalian Genes and Development, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
Development 122:41-52. 1996....
- Distinct regulatory control of the Brachyury gene in axial and non-axial mesoderm suggests separation of mesoderm lineages early in mouse gastrulationD Clements
Department of Biological Sciences, University of Warwick, Coventry, UK
Mech Dev 56:139-49. 1996..Additionally, the data suggest the possibility that axial and non-axial mesoderm are distinct from the earliest stages of Brachyury expression...
- Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene functionC Chiang
Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
Nature 383:407-13. 1996..Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centres...
- Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesisJ D Molkentin
Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
Genes Dev 11:1061-72. 1997..We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP...
- Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryosK L Goh
Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Development 124:4309-19. 1997..Mesodermal markers mox-1, Notch-1, Brachyury (T) and Sonic hedgehog (Shh) were expressed in the mutant embryos in a regionally appropriate fashion...
- Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursorsP Q Thomas
MRC National Institute for Medical Research, London, UK
Development 125:85-94. 1998..Comparison with flk-1 (T. P. Yamaguchi et al...
- Murine cerberus homologue mCer-1: a candidate anterior patterning moleculeC Biben
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
Dev Biol 194:135-51. 1998..The data suggest that mCer-1 shares structural, functional, and expression characteristics with Xcer and may participate in patterning the anterior of the embryo and nascent somite region, in part, through a BMP-inhibitory mechanism...
- Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryoW R Waldrip
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Cell 92:797-808. 1998..Chimera experiments demonstrate these essential activities are contributed by the extraembryonic tissues. Thus, the extraembryonic tissues play critical roles in establishing the body plan during early mouse development...
- Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defectsN D Greene
Neural Development Unit, Institute of Child Health, University College, 30 Guilford Street, London, WC1N 1EH, UK
Mech Dev 73:59-72. 1998..Comparison with other mouse mutants suggests that the enlarged floor plate may be responsible for the failure of neural tube closure in Lp/Lp embryos...
- Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2M Weinstein
Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, 10 9N105, 10 Center Drive, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 95:9378-83. 1998..Molecular analysis showed that smad2 mutant embryos did not undergo gastrulation or make mesoderm. The results demonstrate that smad2 is required for egg cylinder elongation, gastrulation, and mesoderm induction...
- Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activityS J Kinder
Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
Int J Dev Biol 45:347-55. 2001..of the expression pattern of genes associated with the posterior germ layer tissues and the primitive streak (T, Wnt3 and Fgf8) and anterior endoderm (Cer1 and Sox17) revealed that the A-P axis of mutant embryos remains aligned ..
- FoxH1 (Fast) functions to specify the anterior primitive streak in the mouseP A Hoodless
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
Genes Dev 15:1257-71. 2001..These results show that FoxH1 functions in an activin/nodal-Smad signaling pathway that acts upstream of Foxa2 and is required specifically for patterning the APS and node in the mouse...
- Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expressionJ Galceran
Gene Center and Institute of Biochemistry, University of Munich, Feodor Lynenstrasse 25, 81377 Munich, Germany
Proc Natl Acad Sci U S A 98:8668-73. 2001..Together, these data provide genetic evidence that Lef1 mediates the Wnt3a signal and regulates the stable maintenance of Brachyury expression during gastrulation...
- Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repressionGerda Lagger
Institute of Medical Biochemistry, Division of Molecular Biology, University of Vienna, Vienna Biocenter, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
EMBO J 21:2672-81. 2002..Our study provides the first evidence that a histone deacetylase is essential for unrestricted cell proliferation by repressing the expression of selective cell cycle inhibitors...
- Extraembryonic proteases regulate Nodal signalling during gastrulationSéverine Beck
Developmental Biology Group, Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Nat Cell Biol 4:981-5. 2002..A lack of Spc1 and Spc4 affects both pathways because these proteases also stimulate induction of Bmp4...
- TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytesRamireddy Bommireddy
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
J Immunol 170:3645-52. 2003..TGFbeta1 functions to inhibit aberrant T cell expansion by maintaining intracellular calcium concentration levels low enough to prevent a mitogenic response by Ca(2+)-independent stimulatory pathways alone...
- Primitive streak formation in mice is preceded by localized activation of Brachyury and Wnt3Jaime A Rivera-Perez
Department of Genetics, Campus Box 7264, University of North Carolina, Chapel Hill, NC 27599 7264, USA
Dev Biol 288:363-71. 2005....
- Localization of Brachyury (T) in embryonic and extraembryonic tissues during mouse gastrulationKimberly E Inman
Department of Anatomy, University of Wisconsin Madison School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA
Gene Expr Patterns 6:783-93. 2006b>T-box gene family members have important roles during murine embryogenesis, gastrulation, and organogenesis...
- The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathwayHui Jye Chen
Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Genes Dev 20:1933-45. 2006..Reduction of MACF1 in Wnt-1-expressing P19 cells resulted in decreased T (Brachyury) gene expression, a DNA-binding transcription factor that is a direct target of Wnt/beta-catenin ..
- Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branchingAndrew S Rakeman
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Development 133:3075-83. 2006..Thus, the Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo...
- Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentationWilliam C Dunty
Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick, NIH, Frederick, MD 21702, USA
Development 135:85-94. 2008..and Ripply2 in the PSM through the activation of the Notch ligand Dll1 and the mesodermal transcription factors T and Tbx6...
- Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarityHirotaka Tao
Division for Morphogenesis, National Institute for Basic Biology, Myodaiji, Okazaki, Aichi 444 8585, Japan
Proc Natl Acad Sci U S A 106:14426-31. 2009..Our results demonstrate a role for mpk1 in AB polarity formation rather than expected role as a PCP gene...
- Expression pattern of the Brachyury gene in whole-mount TWis/TWis mutant embryosB G Herrmann
Max Planck Institut fur Entwicklungsbiologie, Abt Biochemie, Tubingen, Germany
Development 113:913-7. 1991The murine Brachyury (T) gene is required in mesoderm formation. Mutants carrying different T alleles show a graded severity of defects correlated with gene dosage along the body axis...
- A cell autonomous function of Brachyury in T/T embryonic stem cell chimaerasP Rashbass
AFRC Centre for Genome Research, Edinburgh, UK
Nature 353:348-51. 1991Developmental genetics has shown that the Brachyury (T) gene has a key role in mesoderm formation during gastrulation in the mouse...
- The mouse Brachyury gene and mesoderm formationK Willison
Institute of Cancer Research, Chester Beatty Laboratories, London, UK
Trends Genet 6:104-5. 1990
- Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locusA Shedlovsky
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
Proc Natl Acad Sci U S A 85:180-4. 1988..Although the study of natural variation, including t haplotypes, has yielded some information about the function of these genes, spontaneous variants often exhibit ..
- Genetic analysis of a mouse t complex locus that is homologous to a kidney cDNA cloneE A Mann
Genetics 114:993-1006. 1986..A study of several t haplotypes resulted in the identification of t-specific alleles of D17Rp17 that map to the proximal half of the t ..
- Sex reversal in XY mice caused by dominant mutation on chromosome 17L L Washburn
Nature 303:338-40. 1983..We present here a third autosomal sex-determining locus. This dominantly inherited trait, tentatively named T-associated sex reversal (gene symbol Tas), is closely linked to or a part of the T/t complex on chromosome 17 of the ..
- Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouseG Winnier
Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, Tennessee 37232 2175, USA
Genes Dev 9:2105-16. 1995..Most Bmp-4tm1blh embryos do not proceed beyond the egg cylinder stage, do not express the mesodermal marker T(Brachyury), and show little or no mesodermal differentiation...
- Requirement for Lim1 in head-organizer functionW Shawlot
Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Nature 374:425-30. 1995..A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer...
- A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouseF L Conlon
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138
Development 120:1919-28. 1994..Data presented in this report demonstrate the involvement of a TGF beta-related molecule in axis formation in mammals...
- The Brachyury gene encodes a novel DNA binding proteinA Kispert
Max Planck Institut fur Entwicklungsbiologie, Abt Biochemie, Tubingen, Germany
EMBO J 12:3211-20. 1993Brachyury (T) mutant embryos are deficient in mesoderm formation and do not complete axial development. The notochord is most strongly affected...
- Rescue of the tail defect of Brachyury miceD Stott
Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
Genes Dev 7:197-203. 1993The mouse Brachyury (T) gene is required for normal development of axial structures. Embryos homozygous for the T mutation show severe deficiencies in mesoderm formation...
- A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brainS L Ang
Institute de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, C U de Strasbourg, France
Development 122:243-52. 1996....
- Lack of beta-catenin affects mouse development at gastrulationH Haegel
Max Planck Institut fur Immunbiologie, Freiburg, Germany
Development 121:3529-37. 1995..Our results demonstrate that, although beta-catenin is expressed rather ubiquitously, it is specifically required in the ectodermal cell layer...
- Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryoP Thomas
Laboratory of Mammalian Development, National Institute for Medical Research, Mill Hill, London, UK
Curr Biol 6:1487-96. 1996....
- Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulationD L Chapman
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, New York, 10032, USA
Dev Biol 180:534-42. 1996The T-box genes constitute an evolutionarily conserved family of putative transcription factors which are expressed in discrete domains during embryogenesis, suggesting that they may play roles in inductive interactions...
- Genetic patterning of the developing mouse tail at the time of posterior neuropore closureF Gofflot
Department of Human Anatomy, University of Oxford, United Kingdom
Dev Dyn 210:431-45. 1997..These results provide a foundation for understanding the mechanisms facilitating transition from primary to secondary body axis formation, as well as the factors involved in defective spinal neurulation...
- The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryoC Sirard
Amgen Institute, Toronto, Ontario M5G 2C1, Canada
Genes Dev 12:107-19. 1998..Rescued embryos show severe anterior truncations, indicating a second important role for Smad4 in anterior patterning during embryogenesis...
- The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouseZ Gu
Cardiovascular Research Center, Massachusetts General Hospital East, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Genes Dev 12:844-57. 1998..These results provide genetic evidence that ActRIB functions in both epiblast and extraembryonic cells to mediate signals that are required for egg cylinder organization and gastrulation...
- The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in miceX Yang
Laboratory of Biochemistry and Metabolism, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 95:3667-72. 1998..Altogether, these data demonstrate that SMAD4-mediated signals are required for epiblast proliferation, egg cylinder formation, and mesoderm induction...
- Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryoJ Ding
Center for Advanced Biotechnology and Medicine and Dept of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Nature 395:702-7. 1998..Our results indicate that Cripto signalling is essential for the conversion of a proximal-distal asymmetry into an orthogonal anterior-posterior axis...
- The role of the brachyury gene in heart development and left-right specification in the mouseT King
Department of Anatomy and Developmental Biology, St George s Hospital Medical School, London, UK
Mech Dev 79:29-37. 1998..The mouse brachyury (T) gene encodes a transcription factor which is expressed in the developing notochord and is required for its ..
- Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryoX Sun
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, California 94143 0452 USA
Genes Dev 13:1834-46. 1999..This study identifies Fgf8 as a gene essential for gastrulation and shows that signaling via FGF8 and/or FGF4 is required for cell migration away from the primitive streak...
- Requirement for Wnt3 in vertebrate axis formationP Liu
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nat Genet 22:361-5. 1999..These studies provide genetic proof for the requirement of Wnt3 in primary axis formation in the mouse...
- The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in miceJ Song
Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Dev Biol 213:157-69. 1999..These results provide genetic evidence that type II activin receptors are required for egg cylinder growth, primitive streak formation, and rostral head development in mice...
- Requirement for beta-catenin in anterior-posterior axis formation in miceJ Huelsken
Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
J Cell Biol 148:567-78. 2000..Our data demonstrate that beta-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm...
- Eomesodermin is required for mouse trophoblast development and mesoderm formationA P Russ
Wellcome CRC Institute for Cancer and Developmental Biology, and Department of Physiology, University of Cambridge, UK
Nature 404:95-9. 2000..Here we show that the T-box gene Eomesodermin performs essential functions in both trophoblast development and gastrulation...
- Molecular and embryological characterization of a new transgene-induced null allele of mouse Brachyury locusK Abe
Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
Mamm Genome 11:238-40. 2000
- Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK)Y Xue
New York University Medical Center, Skirball Institute of Biomolecular Medicine, Department of Pharmacology, NY, NY10016, USA
Development 128:1559-72. 2001....
- The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouseM Yamamoto
Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, Japan
Genes Dev 15:1242-56. 2001..These results indicate that a Nodal-FoxH1 signaling pathway plays a central role in A-P patterning and node formation in the mouse...
- Nodal signalling in the epiblast patterns the early mouse embryoJ Brennan
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Nature 411:965-9. 2001..Our experiments show that proximal-distal and subsequent anterior-posterior polarity of the pregastrulation embryo result from reciprocal cell-cell interactions between the epiblast and the two extra-embryonic tissues...
- C57BL/6J-T-associated sex reversal in mice is caused by reduced expression of a Mus domesticus Sry alleleL L Washburn
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Genetics 158:1675-81. 2001C57BL/6J-T-associated sex reversal (B6-TAS) in XY mice results in ovarian development and involves (1) hemizygosity for Tas, a gene located in the region of Chromosome 17 deleted in T(hp) and T(Orl), (2) homozygosity for one or more B6-..
- FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streakB Ciruna
Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
Dev Cell 1:37-49. 2001..We propose that modulation of cytoplasmic beta-catenin levels, associated with FGF-induced downregulation of E-cadherin, provides a molecular link between FGF and Wnt signaling pathways at the streak...
- Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endodermHeiko Lickert
Department of Molecular Embryology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
Dev Cell 3:171-81. 2002..We provide evidence that ablation of beta-catenin in embryonic endoderm changes cell fate from endoderm to precardiac mesoderm, consistent with the existence of bipotential mesendodermal progenitors in mouse embryos...
- Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaksAitana Perea-Gomez
IGBMC CNRS INSERM, Universite Louis Pasteur, 67404 Illkirch Cedex, CU de, Strasbourg, France
Dev Cell 3:745-56. 2002..Both antagonists are also required for proper patterning of the primitive streak...
- Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryosDeanna Mohn
Department of Medicine, Mount Sinai School of Medicine, New York, New York 10128, USA
Dev Dyn 226:446-59. 2003..Intriguingly, mMix mRNA is detected in a population (T+Flk1+) of cells which may contain hemangioblasts, before the onset of hematopoiesis and activation of hematopoietic ..
- Wnt3a plays a major role in the segmentation clock controlling somitogenesisAlexander Aulehla
Abteilung Entwicklungsbiologie, Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108, Freiburg, Germany
Dev Cell 4:395-406. 2003..We propose that the segmentation clock is established by Wnt/beta-catenin signaling via a negative-feedback mechanism and that Wnt3a controls the segmentation process in vertebrates...
- The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin networkFriedhelm Bladt
Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
Mol Cell Biol 23:4586-97. 2003..These data suggest that the Nck SH2/SH3 adaptors have important functions in the development of mesodermal structures during embryogenesis, potentially linked to a role in cell movement and cytoskeletal organization...
- Cell fate decisions within the mouse organizer are governed by graded Nodal signalsStephane D Vincent
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genes Dev 17:1646-62. 2003..These findings conclusively demonstrate that graded Nodal/Smad2 signals govern allocation of the axial mesendoderm precursors that selectively give rise to the ADE and PCP mesoderm...
- Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryoN Ray Dunn
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Development 131:1717-28. 2004..Collectively, these results demonstrate that dose-dependent Smad2 and Smad3 signals cooperatively mediate cell fate decisions in the early mouse embryo...
- Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fatesAmer Ahmed Rana
Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 131:4999-5007. 2004....
- Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endodermChiharu Kimura-Yoshida
Vertebrate Body Plan Group, RIKEN Center for Developmental Biology CDB, 2 2 3 Minatojima minami cho, Chuou ku Kobe, Hyogo 650 0047, Japan
Dev Cell 9:639-50. 2005..We propose that Wnt/beta-catenin signaling mediates A-P axis polarization by guiding cell migration toward the prospective anterior in the pregastrula mouse embryo...
- Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulationJianbo Wang
Department of Pediatrics and Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0627, La Jolla, CA 92093 0627, USA
Development 133:1767-78. 2006..These results are discussed in light of recent models on PCP and convergent extension...
- Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cellsAtsushi Suzuki
Gene Expression Laboratory, Stem Cell Research Center, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 103:10294-9. 2006..Here, we show that Nanog expression is up-regulated in mouse ES cells by the binding of T (Brachyury) and STAT3 to an enhancer element in the mouse Nanog gene...
- Disruption of early proximodistal patterning and AVE formation in Apc mutantsClaire Chazaud
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
Development 133:3379-87. 2006..In addition, we found that nuclear beta-catenin and other molecular markers are asymmetrically expressed by 4.5 days...
- The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4Nadav Ben-Haim
Ecole Polytechnique Fédérale de Lausanne EPFL ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Dev Cell 11:313-23. 2006..Based on mathematical modeling, we discuss how these sequential loops control cell fate...
- Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryoTakashi Inoue
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
Dev Biol 306:669-84. 2007....
- Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6Lars Wittler
Department of Developmental Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
EMBO Rep 8:784-9. 2007..factor, which is essential for psm maturation, is regulated by synergism between WNT signalling and the T-box 6 transcription factor, involving a feed-forward control mechanism...
- Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic developmentOlov Andersson
Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
Dev Biol 311:500-11. 2007....
- ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATIONVIRGINIA PAPAIOANNOU; Fiscal Year: 2003..Specific Aim 4. To isolate and characterize additional members of the Tbx6 subfamily in the mouse with special emphasis on isolating the orthologs of genes known in other species to play a role in mesoderm development. ..
- Islet growth in NOD mice tolerant to autoimmune diabetesVIRGINIA PAPAIOANNOU; Fiscal Year: 2005..By combining the expertise of the two Pl's to address the problems of islet autoimmunity and beta cell deficiency our proposal will test a combination strategy that may be useful in patients. ..
- Multistep Lymphomagenesis/Tumorigenesis in Transgenic Mice: Protein Kinase Ck2David C Seldin; Fiscal Year: 2010..Since CK2 is upregulated in all human tumors that have been studied, CK2 may be a suitable target for cancer treatment. Understanding basic CK2 biology and signaling is a necessary prelude to developing novel therapeutics against it. ..
- Role of T-box Genes in Mouse DevelopmentVIRGINIA PAPAIOANNOU; Fiscal Year: 2006The long-term objectives of this project are to understand the evolution of the T-box family of transcription factor genes, to determine their role in embryonic development...
- 2008 Basement Membranes Gordon Research ConferenceJEFFREY MINER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- 2006 Gordon Research Conference on Basement MembranesJEFFREY MINER; Fiscal Year: 2006..Studies on the genetic analyses of basement membrane functions and the generation of animal models of human basement membrane disorders will be presented. [unreadable] [unreadable] [unreadable] [unreadable]..
- ISOLATION OF NOVEL MUTATIONS AFFECTING THE MOUSE EMBRYOKathryn Anderson; Fiscal Year: 2007..The signaling pathways that act in early development also have critical roles in tumor development, so it is likely that these genes identified in this study will define new steps in tumor development and progression. ..
- Laminin Alpha5 and Polycystic Kidney DiseaseJEFFREY MINER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- The role of cell polarity in vertebrate limb outgrowthJeffery Barrow; Fiscal Year: 2007..Furthermore he will examine the epistatic relationship between Fgf and Wnt/PCP signaling in regulating cell polarity. [unreadable] [unreadable] [unreadable]..
- Mechanisms of Cell/Matrix Interactions in the KidneyJEFFREY MINER; Fiscal Year: 2006..Together, the results of these studies will lead to a more complete understanding of cell-matrix interactions in the kidney and could reveal new avenues for diagnosis and treatment of human kidney disease. ..
- Epithelial Cell Structure in Vertebrate DevelopmentJeffrey D Hildebrand; Fiscal Year: 2010..We will continue to use in vivo studies in mice and in vitro studies in cell culture to understand the molecular mechanisms underlying human birth defects. ..
- T-box gene effects on left-right body axis determinationVirginia E Papaioannou; Fiscal Year: 2010..We will investigate the roles of two T-box transcription factor genes, Brachyury (T) and Tbx6...
- ASSEMBLY AND FUNCTION OF BASEMENT MEMBRANE PROTEINSJEFFREY MINER; Fiscal Year: 2008..The results of these studies will lead to new information regarding the assembly and function of laminins in the in vivo setting. ..
- COLLAGEN IV CHAINS IN KIDNEY DEVELOPMENT AND FUNCTIONJEFFREY MINER; Fiscal Year: 2002..The results obtained under the auspices of this proposal will have important implication for the pathogenesis of Alport syndrome in man and for approaches current under development that will use gene therapy to treat the human disease. ..
- Recessive Mutations that Disrupt Develop of Mouse EmbryoKathryn Anderson; Fiscal Year: 2006..All new polymorphic mapping markers and new methods will be made available to the community as electronic resources. ..
- Zic3 and the Control of Body Pattern FormationSTEPHANIE WARE; Fiscal Year: 2005..Through a combination of supervised research, scientific interchange, and selected coursework within this environment, the candidate will obtain the training necessary to transition to an independent investigator. ..
- 58TH SOCIETY FOR DEVELOPMENTAL BIOLOGY ANNUAL MEETINGKathryn Anderson; Fiscal Year: 2003..The afternoons will be devoted to poster sessions and workshops. A special education symposium will address issues for teachers and for those interested in presenting science to the broader community. ..
- VASCULOGENESIS IN THE MURINE ALLANTOISKAREN DOWNS; Fiscal Year: 2002..Further, results of our experiments will shed light on the mechanism of formation of the endothelial cell lineage. ..