Th

Summary

Gene Symbol: Th
Description: tyrosine hydroxylase
Alias: tyrosine 3-monooxygenase, tyrosine 3-hydroxylase
Species: mouse

Top Publications

  1. ncbi A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
    M P Smidt
    Section of Molecular Neuroscience, Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Medical Faculty, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Nat Neurosci 3:337-41. 2000
  2. pmc Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting
    Sharon M Kolk
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 29:12542-57. 2009
  3. doi Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression
    Frank M J Jacobs
    Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:531-40. 2009
  4. ncbi Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
    A Abeliovich
    Department of Neurology, University of California, San Francisco 94143, USA
    Neuron 25:239-52. 2000
  5. ncbi Dopamine neuron agenesis in Nurr1-deficient mice
    R H Zetterström
    Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    Science 276:248-50. 1997
  6. pmc Math1 is essential for the development of hindbrain neurons critical for perinatal breathing
    Matthew F Rose
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 64:341-54. 2009
  7. doi Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse
    Agnès Espana
    Universite Catholique de Louvain, Institute of Neuroscience, Laboratory of Neural Differentiation, Brussels, B 1200, Belgium
    J Comp Neurol 520:1424-41. 2012
  8. pmc Pet-1 is required across different stages of life to regulate serotonergic function
    Chen Liu
    Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
    Nat Neurosci 13:1190-8. 2010
  9. ncbi Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain
    Anil Bagri
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:233-48. 2002
  10. pmc Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:2363-73. 2009

Research Grants

Detail Information

Publications179 found, 100 shown here

  1. ncbi A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
    M P Smidt
    Section of Molecular Neuroscience, Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Medical Faculty, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Nat Neurosci 3:337-41. 2000
    ..Although disruption of this cascade did not block induction of tyrosine hydroxylase (TH), a key enzyme in DA synthesis, or Nurr1, a nuclear hormone receptor, Lmx1b knockout mice failed to induce the mesDA-..
  2. pmc Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting
    Sharon M Kolk
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 29:12542-57. 2009
    ..mdDA pathway development using tissue culture approaches and analysis of sema3F(-/-), npn-2(-/-), and npn-2(-/-);TH-Cre mice...
  3. doi Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression
    Frank M J Jacobs
    Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:531-40. 2009
    ....
  4. ncbi Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
    A Abeliovich
    Department of Neurology, University of California, San Francisco 94143, USA
    Neuron 25:239-52. 2000
    ..These findings support the hypothesis that alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission...
  5. ncbi Dopamine neuron agenesis in Nurr1-deficient mice
    R H Zetterström
    Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    Science 276:248-50. 1997
    ..These results suggest that putative Nurr1 ligands may be useful for treatment of Parkinson's disease and other disorders of midbrain dopamine circuitry...
  6. pmc Math1 is essential for the development of hindbrain neurons critical for perinatal breathing
    Matthew F Rose
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 64:341-54. 2009
    ..This study identifies Math1-dependent neurons that are critical for perinatal breathing that may link proprioception and arousal with respiration...
  7. doi Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse
    Agnès Espana
    Universite Catholique de Louvain, Institute of Neuroscience, Laboratory of Neural Differentiation, Brussels, B 1200, Belgium
    J Comp Neurol 520:1424-41. 2012
    ..Hence, Onecut factors are markers of the A13 nucleus throughout embryonic development. They are dispensable for the first phase of A13 development but are required for the second phase of development and for maintenance of this nucleus...
  8. pmc Pet-1 is required across different stages of life to regulate serotonergic function
    Chen Liu
    Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
    Nat Neurosci 13:1190-8. 2010
    ..These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription...
  9. ncbi Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain
    Anil Bagri
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:233-48. 2002
    ....
  10. pmc Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:2363-73. 2009
    ....
  11. pmc Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals
    James P Dugan
    Department of Biology, University of Nevada, Reno, NV 89557, USA
    Mol Cell Neurosci 46:347-56. 2011
    ..test the potential roles of Slit/Robo guidance in ascending trajectories, we examined tyrosine hydroxylase-positive (TH+) projections from mdDA neurons in mutant mouse embryos...
  12. ncbi Sema3a maintains normal heart rhythm through sympathetic innervation patterning
    Masaki Ieda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Med 13:604-12. 2007
    ..We conclude that appropriate cardiac Sema3a expression is needed for sympathetic innervation patterning and is critical for heart rate control...
  13. ncbi Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem
    A Wallén A
    Ludwig Institute for Cancer Research, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Mol Cell Neurosci 18:649-63. 2001
    ..In conclusion, regulation of Ret by Nurr1 in midbrain DA neurons and in the DMN has implications for both embryonal development and adult physiology in which signaling by neurotrophic factors plays important roles...
  14. ncbi EphB1 null mice exhibit neuronal loss in substantia nigra pars reticulata and spontaneous locomotor hyperactivity
    A Brent Richards
    Department of Neuroscience, Georgetown University, Washington, DC 20007, USA
    Eur J Neurosci 25:2619-28. 2007
    ..In situ hybridization data and a direct comparison of SN neurons expressing tyrosine hydroxylase (TH) and/or the beta-gal marker for EphB1 revealed that EphB1 is not expressed in TH+ neurons of pars compacta (SNc), ..
  15. ncbi Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 134:2673-84. 2007
    ..The number of tyrosine hydroxylase-positive (TH+) neurons was significantly increased after RA treatment in the rostral mdDA region of Pitx3-/- embryos...
  16. pmc Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium
    Neeraja Sammeta
    Department of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
    Mol Cell Neurosci 45:398-407. 2010
    ..These data suggest that UNCX acts downstream of neural determination factors to broadly control transcriptional mechanisms used by neural progenitor cells to specify neural phenotypes...
  17. doi Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity
    Yannis E Mavromatakis
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Mech Dev 128:90-103. 2011
    ..Altogether, these data indicate that Foxa1 and Foxa2 contribute to the specification of ventral midbrain progenitor identity by regulating Shh signalling in a positive and negative manner...
  18. pmc Modular patterning of structure and function of the striatum by retinoid receptor signaling
    Wen Lin Liao
    Institute of Neuroscience, Center of Neuroscience, Department of Life Sciences, National Yang Ming University, Taipei, Taiwan 112, Republic of China
    Proc Natl Acad Sci U S A 105:6765-70. 2008
    ..RARbeta signaling thus plays a crucial role in setting up striatal compartments that may engage in neural circuits of psychomotor control...
  19. pmc Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools
    Milan Joksimovic
    Northwestern University Feinberg School of Medicine, Department of Neurology and Center for Genetic Medicine, 7 113 Lurie Building, 303 East Superior Street, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:19185-90. 2009
    ..This refined ontogenetic definition will expand understanding of dopamine neuron biology and selective susceptibility, and will impact stem cell-derived therapies and models for PD...
  20. pmc The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system
    S Britsch
    Department of Medical Genetics, Max Delbruck Center MDC for Molecular Medicine, 13122 Berlin, Germany
    Genes Dev 12:1825-36. 1998
    ..Together with previous observations, these findings establish the neuregulin signaling system as a key regulator in the development of neural crest cells...
  21. ncbi Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage
    Hendrik Wildner
    Max Delbrück Centrum for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Development 135:473-81. 2008
    ..of sympatho-adrenal precursors, as assessed by the expression of neuronal subtype-specific genes such as Th and Dbh, is delayed in a pronounced manner, which is accompanied by a reduced proliferation...
  22. ncbi The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
    A Pattyn
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS INSERM Université de la Méditterranée AP de Marseille, France
    Nature 399:366-70. 1999
    ....
  23. doi Shh dependent and independent maintenance of basal midbrain
    Ariadna Perez-Balaguer
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Mech Dev 126:301-13. 2009
    ..Based on our results and recently published data, we suggest the existence of a specific genetic pathway for the specification of the mesencephalic red nucleus. Foxa2 could be the candidate gene that might control this genetic pathway...
  24. pmc Wnt5a mediates nerve growth factor-dependent axonal branching and growth in developing sympathetic neurons
    Daniel Bodmer
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 29:7569-81. 2009
    ..Together, our findings define a novel regulatory pathway in which Wnt5a, expressed in sympathetic neurons in response to target-derived NGF, regulates innervation of peripheral targets...
  25. ncbi Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur J Neurosci 18:1731-8. 2003
    ..factors, is essential for establishing the dopaminergic phenotype, because expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine synthesis, requires Nurr1...
  26. ncbi Transforming growth factor beta is required for differentiation of mouse mesencephalic progenitors into dopaminergic neurons in vitro and in vivo: ectopic induction in dorsal mesencephalon
    Eleni Roussa
    Department for Neuroanatomy, Georg August University, DFG Research Center of Molecular Physiology of the Brain, University of Gottingen, Kreuzbergring 36, D 37075 Gottingen, Germany
    Stem Cells 24:2120-9. 2006
    ..with transforming growth factor beta (TGF-beta) increased the number of Nurr1- and tyrosine hydroxylase (TH)-immunoreactive cells, which can be further increased when the spheres are treated with TGF-beta in combination with ..
  27. pmc Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system
    Yuka Morikawa
    Department of Cell and Molecular Biology, Tulane University, 2000 Percival Stern Hall, New Orleans, LA 70118, USA
    Dev Biol 307:114-26. 2007
    ..noradrenergic differentiation, the levels of the norepinephrine biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) was examined...
  28. ncbi Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner
    Anna L M Ferri
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 134:2761-9. 2007
    ..Altogether, our results demonstrate that Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner...
  29. ncbi Expression of the neuronal calcium sensor protein NCS-1 in the developing mouse olfactory pathway
    Helen B Treloar
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Comp Neurol 482:201-16. 2005
    ..Together, these data suggest multiple and overlapping roles of NCS-1 in the developing and mature olfactory system...
  30. pmc Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain
    John Jacob
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 136:2477-85. 2009
    ..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations...
  31. doi Dynamic expression and heterogeneous intracellular location of En-1 during late mouse embryonic development
    Shan Chuan Zhong
    Department of Histology and Embryology, Third Military Medical University, Chongqing, Republic of China
    Cells Tissues Organs 191:289-300. 2010
    ..These findings provided additional evidence that En-1 may be involved in the development of neural crest cells...
  32. pmc Inactivation of Dicer1 in Steroidogenic factor 1-positive cells reveals tissue-specific requirement for Dicer1 in adrenal, testis, and ovary
    Chen Che J Huang
    Department of Veterinary Biosciences, University of Illinois, Urbana, IL, USA
    BMC Dev Biol 10:66. 2010
    ..Mouse embryos lacking Dicer1 die in early embryogenesis. In this study, we investigated whether Dicer1 is required for development of adrenal, testis, and ovary in mouse embryos...
  33. doi Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes-diencephalic basal plate
    Juan Antonio Moreno-Bravo
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Cientificas, and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Dev Dyn 239:2094-101. 2010
    ..The nuclei integrated in this domain would be the rostral interstitial nucleus, the interstitial nucleus of Cajal, and a mesencephalic equivalent to these nuclei...
  34. ncbi Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
    Marten P Smidt
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 131:1145-55. 2004
    ..5, a time when tyrosine hydroxylase (Th) gene expression is initiated...
  35. doi Delayed dopaminergic neuron differentiation in Lrp6 mutant mice
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Dev Dyn 239:211-21. 2010
    ..5. Our results, therefore, suggest a role for Lrp6 in the onset of DA neuron development in the VM as well as a role in midbrain morphogenesis...
  36. ncbi Intricate regulation of tyrosine hydroxylase activity and gene expression
    S C Kumer
    Department of Physiology and Pharmacology, The Bowman Gray School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157 1083, USA
    J Neurochem 67:443-62. 1996
    ....
  37. ncbi Evidence for intrinsic development of olfactory structures in Pax-6 mutant mice
    D Jimenez
    Instituto Cajal C S I C, E 28002 Madrid, Spain
    J Comp Neurol 428:511-26. 2000
    ..The intrinsic mechanisms and environmental cues in the telencephalon could be sufficient to promote axonogenesis in the projection neurons of the OB and guide their axons in a lateral prospective tract, in the absence of olfactory axons...
  38. ncbi Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo
    Daphne M Hasbani
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:9428-33. 2005
    ..These results suggest that DA does not contribute to acute MPTP toxicity in vivo...
  39. ncbi A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo
    Nilima Prakash
    GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, 85764 Munich Neuherberg, Germany
    Development 133:89-98. 2006
    ..They also suggest the Wnt1-controlled signaling pathway as a promising target for new therapeutic strategies in the treatment of Parkinson's disease...
  40. ncbi Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain
    Nina Rawal
    Laboratory of Molecular Neurobiology, Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vag 1, A1 2, 171 77 Stockholm, Sweden
    Exp Cell Res 312:1626-36. 2006
    ..in different cell types and examined neuronal-progenitor- or glial-enriched cultures and DA neurons isolated from TH-GFP reporter mice. We found that Fz8 is expressed at high levels in DA neurons at E11.5 and E13.5...
  41. ncbi Megane/Heslike is required for normal GABAergic differentiation in the mouse superior colliculus
    Jordi Guimera
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, 35 8006, Ingolstädter Landstrasse, 1, Neuherberg, Germany
    Development 133:3847-57. 2006
    ..Vertebrate h/E(spl)-related genes can no longer be regarded solely as a factors that confer generic neurogenic properties, but as key components for the subtype-neuronal identity in the mammalian CNS...
  42. pmc A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors
    Minoree Kohwi
    Department of Neurosurgery, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:6878-91. 2007
    ..We show that calretinin+, calbindin+, and dopaminergic (TH+) periglomerular OB interneurons correspond to distinct subtypes of GABAergic cells; all were produced in the ..
  43. pmc Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids
    Y Sadovsky
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 92:10939-43. 1995
    ..These results confirm that SF-1 is an important regulator of adrenal and gonadal development, but its regulation of steroid hydroxylase expression in vivo remains to be established...
  44. ncbi Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
    F Guillemot
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Cell 75:463-76. 1993
    ..These observations suggest that Mash-1, like its Drosophila homologs of the AS-C, controls a basic operation in development of neuronal progenitors in distinct neural lineages...
  45. ncbi Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
    L Sussel
    Center for Neurobiology and Psychiatry, Department of Psychiatry and University of California at San Francisco, CA 94143 0984, USA
    Development 126:3359-70. 1999
    ..We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage...
  46. ncbi Frizzled-3 is required for the development of major fiber tracts in the rostral CNS
    Yanshu Wang
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 22:8563-73. 2002
    ..In contrast, there is little cell death, as assayed by terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling, in the cortex. These data provide the first link between Frizzled signaling and axonal development...
  47. pmc Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression
    Masaki Ieda
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tookyo, Japan
    J Clin Invest 113:876-84. 2004
    ..These findings indicate that endothelin-1 regulates NGF expression in cardiomyocytes and plays a critical role in sympathetic innervation of the heart...
  48. ncbi Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons
    Lavinia Alberi
    Department of Neuroanatomy, Interdisciplinary Center of Neuroscience, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Development 131:3229-36. 2004
    ..This rapid induction of cell death in mDA neurons suggests that the engrailed genes participate directly in the regulation of apoptosis, a proposed mechanism for Parkinson's disease...
  49. pmc AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons
    Francesca M Theriault
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 101:10343-8. 2004
    ..Runx1 inactivation also leads to a loss of selected sensory neurons in trigeminal and vestibulocochlear ganglia. These findings uncover previously unrecognized roles for Runx1 in the regulation of mammalian neuronal subtype development...
  50. ncbi Lack of an adrenal cortex in Sf1 mutant mice is compatible with the generation and differentiation of chromaffin cells
    Philipp Gut
    Neuroanatomy and Interdisciplinary Center for Neurosciences IZN of Heidelberg, INF 307, D 69120 Heidelberg, Germany
    Development 132:4611-9. 2005
    ..5. However, already at E12.5 the 'adrenal' region in Sf1-/- mice is occupied by fewer PHOX2B+ and TH+ SA cells as well as SOX10+ neural crest cells...
  51. ncbi Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage
    Pierre Val
    Section of Gene Function and Regulation, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Development 134:2349-58. 2007
    ..These results highlight the importance of transcription factor dosage in organogenesis and the role of transcription co-factors such as Cited2 in determining the levels of these factors...
  52. ncbi Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons
    Matthias Bauer
    GSF National Research Center for Environment and Health, Institute of Human Genetics, Munich Neuherberg, Germany
    J Neurochem 104:1101-15. 2008
    ..5 (E11.5) followed by exclusive expression in tyrosine 3-monooxygenase (TH) positive neurons from E12.5 onwards...
  53. doi Tyrosine hydroxylase-positive GABAergic juxtaglomerular neurons are the main source of the interglomerular connections in the mouse main olfactory bulb
    Toshio Kosaka
    Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Neurosci Res 60:349-54. 2008
    ..Thus, the long interglomerular connections were mainly made by a particular type of dopaminergic-GABAergic juxtaglomerular neurons...
  54. pmc Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice
    Tshianda N M Alerte
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, United States
    Neurosci Lett 435:24-9. 2008
    Tyrosine hydroxylase (TH), the rate limiting enzyme in catecholamine synthesis, is frequently used as a marker of dopaminergic neuronal loss in animal models of Parkinson's disease (PD)...
  55. doi Development of satellite glia in mouse sympathetic ganglia: GDNF and GFR alpha 1 are not essential
    Thomas Callahan
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria 3010, Australia
    Glia 56:1428-37. 2008
    ..was examined by localizing the transcription factors, Sox10 and Phox2b, the neuronal marker, tyrosine hydroxylase (TH), and brain-derived fatty acid binding protein (B-FABP), which identifies glial precursors and mature glia. In E10...
  56. pmc Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo
    Emma R Andersson
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 3:e3517. 2008
    ..and flattened, a typical CE phenotype, and the domains occupied by Ngn2+ DA progenitors, NR4A2+ DA precursors and TH+ DA neurons were rostrocaudally reduced and laterally expanded...
  57. doi Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome
    Chantal F Medina
    Regenerative Medicine, Ottawa Health Research Institute, Ottawa, Ontario, Canada K1H 8L6
    Hum Mol Genet 18:966-77. 2009
    ..These results implicate a role for Atrx in interneuron survival and differentiation...
  58. doi Targeted disruption of Sonic Hedgehog in the mouse adrenal leads to adrenocortical hypoplasia
    Saunders Ching
    Department of Human Genetics, University of California, Los Angeles, California, USA
    Genesis 47:628-37. 2009
    ..Taken together, these results establish a direct role for Shh signaling in normal adrenal development...
  59. pmc Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog
    Chen Che Jeff Huang
    Department of Veterinary Biosciences, University of Illinois, 2001 South Lincoln Avenue, Urbana, Illinois 61802, USA
    Endocrinology 151:1119-28. 2010
    ..Our results not only provide the genetic evidence to support that the adrenal capsule contributes to the growth of adrenocortex in both fetal and adult life but also identify a novel role of Shh in this process...
  60. ncbi Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
    Q Y Zhou
    Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle 98195 7370, USA
    Cell 83:1197-209. 1995
    ..synthesize dopamine (DA) specifically in dopaminergic neurons were created by inactivating the tyrosine hydroxylase (TH) gene then by restoring TH function in noradrenergic cells...
  61. ncbi TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo
    A M Fagan
    Department of Molecular Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    J Neurosci 16:6208-18. 1996
    ..Moreover, these observations raise the possibility that at least some SCG neurons become neurotrophin-dependent before complete target innervation...
  62. ncbi Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain
    P Onyango
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genome Res 10:1697-710. 2000
    ..This study provides the first global view of the architecture of an entire imprinted domain and provides candidate sequence elements for subsequent functional analyses...
  63. ncbi Fate of midbrain dopaminergic neurons controlled by the engrailed genes
    H H Simon
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 21:3126-34. 2001
    ..However, the engrailed genes control the survival of midbrain dopaminergic neurons in a gene dose-dependent manner. Our findings also suggest a link between engrailed and Parkinson's disease...
  64. ncbi Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system
    Takahiko Kawasaki
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Development 129:671-80. 2002
    ....
  65. ncbi Developmental timing of hair follicle and dorsal skin innervation in mice
    Eva M J Peters
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Hamburg D 20246, Germany
    J Comp Neurol 448:28-52. 2002
    ..This sequence of developing innervation consistently correlates with hair follicle development, indicating a close interdependence of neuronal and epithelial morphogenesis...
  66. ncbi A role for midbrain arcs in nucleogenesis
    Seema Agarwala
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, IL 60637, USA
    Development 129:5779-88. 2002
    ..Taken together, these findings suggest that arcs represent a patterning mechanism by which midbrain progenitor cells are allocated to specific nuclear fates...
  67. ncbi Lack of Reelin causes malpositioning of nigral dopaminergic neurons: evidence from comparison of normal and Reln(rl) mutant mice
    Shigeyuki Nishikawa
    Laboratory of Neurobiology, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto 860 8556, 1 1 1 Honjo, Japan
    J Comp Neurol 461:166-73. 2003
    ..We hypothesize that Reelin plays a role in the positioning of nigral dopaminergic neurons and that it can act as an environmental cue at a remote site far from its birthplace via a transaxonal delivery system...
  68. ncbi Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer
    Claude Brodski
    Max Planck Institute of Psychiatry, 80804 Munich, Germany, and GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, 85758 Oberschleissheim, Germany
    J Neurosci 23:4199-207. 2003
    ..In addition, our data suggest that the position of the MHO during embryogenesis can modulate adult locomotor activity...
  69. ncbi Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1
    Hitoshi Kawano
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, 183 8526, Japan
    Exp Neurol 182:103-12. 2003
    ..1-deficient mice, the abnormal crossing of ascending DA axons observed may be attributed to the elimination of these chemorepulsive signals in the medial part of the mutant hypothalamus...
  70. ncbi Heterogeneous requirement of NGF for sympathetic target innervation in vivo
    Natalia O Glebova
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:743-51. 2004
    ..Remarkably, target organs vary widely in their individual NGF requirements for sympathetic innervation...
  71. ncbi Essential role of Gata transcription factors in sympathetic neuron development
    Konstantina Tsarovina
    Max Planck Institut für Hirnforschung, Abteilung Neurochemie, Deutschordenstr 46, 60528 Frankfurt Main, Germany
    Development 131:4775-86. 2004
    ..starts after Mash1, Phox2b, Hand2 and Phox2a expression, but before the onset of the noradrenergic marker genes Th and Dbh, and is maintained throughout development...
  72. ncbi Transgenic expression of Cre recombinase from the tyrosine hydroxylase locus
    Jonas Lindeberg
    Department of Neuroscience, Developmental Neuroscience Unit, Uppsala University, Biomedical Center, SE 751 23 Uppsala, Sweden
    Genesis 40:67-73. 2004
    Catecholaminergic neurons are affected in several neurological and psychiatric diseases. Tyrosine hydroxylase (TH) is the first, rate-limiting enzyme in catecholamine synthesis...
  73. ncbi Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons
    Julianna Kele
    Laboratory of Molecular Neurobiology, MBB, Karolinska Institutet, Retzius building A1, Stockholm, Sweden
    Development 133:495-505. 2006
    ..These results demonstrate that Ngn2 is uniquely required for the development of midbrain dopaminergic neurons...
  74. ncbi Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla
    Stephan Oberle
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 26:1823-32. 2006
    ..Thus, both somatic motoneurons and PSNs in the spinal cord depend on LIFRbeta signaling for their development and maintenance, although PSNs seem to be overall less affected than somatic motoneurons by LIFRbeta deprivation...
  75. ncbi Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cells
    David E G McNay
    Division of Developmental Neurobiology, Medical Research Council, The National Institute of Medical Research, Mill Hill, London NW7 1AA, UK
    Mol Endocrinol 20:1623-32. 2006
    ..and subsequent GHRH expression, positively regulates SF1 expression, and suppresses both tyrosine hydroxylase (TH) and neuropeptide Y (NPY) expression...
  76. ncbi Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
    Sandra Blaess
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 133:1799-809. 2006
    ..Thus, the precise spatial and temporal regulation of Gli2A and Gli3R by Shh is instrumental in coordinating mid/hindbrain development in three dimensions...
  77. pmc Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia
    Thomas S Hnasko
    Graduate Program in Neurobiology and Behavior, Department of Biochemistry, and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 103:8858-63. 2006
    ..These DD floxed stop (DDfs) mice have a nonfunctional Tyrosine hydroxylase (Th) gene because of insertion of a NeoR gene flanked by lox P sites targeted to the first intron of the Th gene...
  78. pmc Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina
    Liang Feng
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Development 133:4815-25. 2006
    ..Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes...
  79. pmc Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons
    Jiasheng Zhang
    Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Nat Neurosci 10:77-86. 2007
    ..These data underscore the importance of the TGFbeta-Smad-HIPK2 pathway in the survival of DA neurons and its potential as a therapeutic target for promoting DA neuron survival during neurodegeneration...
  80. ncbi Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells
    Yuichi Ono
    KAN Research Institute Inc, KobeMI R and D Center 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Development 134:3213-25. 2007
    ..Our data provide insights into the mechanisms of specification and generation of mesDA neurons, and illustrate a useful cell replacement approach for Parkinson's disease...
  81. pmc Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons
    Tyler J Hendershot
    Department of Neurosciences, Program in Neurosciences and Degenerative Disease, University of Toledo Health Sciences Center, Toledo, OH 43614, USA
    Dev Biol 319:179-91. 2008
    ..disruption of Hand2 results in a significant and progressive loss of neurons as well as a significant loss of TH expression...
  82. doi Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex
    Alex C Kim
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0678 USA
    Development 135:2593-602. 2008
    ..These results define crucial roles for beta-catenin--presumably as part of the Wnt canonical signaling pathway--in both embryonic development of the adrenal cortex and in maintenance of the adult organ...
  83. doi Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis
    Milan Joksimovic
    Northwestern University Feinberg Medical School, Department of Neurology and Center for Genetic Medicine, 7 113 Lurie Bldg, 303 E Superior Street, Chicago, Illinois 60611, USA
    Nat Neurosci 12:125-31. 2009
    ..These findings demonstrate how the dynamic interplay of canonical Wnt/beta-catenin signaling and Shh may orchestrate floor plate neurogenesis or a lack thereof...
  84. pmc Gene regulatory logic of dopamine neuron differentiation
    Nuria Flames
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Nature 458:885-9. 2009
    ..Our studies reveal a simple and apparently conserved regulatory logic of dopamine neuron terminal differentiation and may provide new entry points into the diagnosis or therapy of conditions in which dopamine neurons are defective...
  85. pmc Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons
    Mianzhi Tang
    VA Medical Center and Department of Pathology, University of California San Francisco, San Francisco, CA 94121, USA
    Development 136:2027-38. 2009
    ..By contrast, Th-IRES-Cre removes beta-catenin in a subset of neural progenitor cells without perturbing the cellular and structural ..
  86. doi Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development
    Wei Lin
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    Dev Biol 333:386-96. 2009
    ..Chromatin immunoprecipitation experiments indicate that Nkx2.2 and TH genes are likely direct targets of Foxa1 and Foxa2 in mesodiencephalic dopaminergic cells in vivo...
  87. pmc Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons
    Rachel Hammond
    Department of Pathology, Center for Neurobiology and Behavior and Taub Institute, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 4:e7007. 2009
    ..Furthermore, Shh signaling is involved in determining the structural diversity of these dopaminergic projections...
  88. doi Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon
    Tomoya Nakatani
    KAN Research Institute Inc, Kobe MI R and D Center, 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Dev Biol 339:101-13. 2010
    ....
  89. pmc Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system
    Michaela R Potzner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    Development 137:775-84. 2010
    ..As a consequence, sympathetic ganglia were rudimentary in the adult and sympathetic innervation of target tissues was impaired leading to severe dysautonomia...
  90. pmc Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents
    Colleen Manitt
    Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Canada
    PLoS ONE 5:e11463. 2010
    ..Together, our findings suggest that DCC:UNC5H ratios in DA neurons at critical periods may have important consequences for the organization and function of mesocorticolimbic DA systems...
  91. pmc Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem
    Ali G Fenstermaker
    University of California, San Diego, La Jolla, CA 92093, USA
    J Neurosci 30:16053-64. 2010
    ..Overall, our data suggest that Wnt/planar cell polarity signaling may be a global anterior-posterior guidance mechanism that controls axonal and cellular organization beyond the spinal cord...
  92. pmc Isoform-specific dephosphorylation of dynamin1 by calcineurin couples neurotrophin receptor endocytosis to axonal growth
    Daniel Bodmer
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuron 70:1085-99. 2011
    ..Thus, NGF-dependent phosphoregulation of dynamin1 is a critical event coordinating neurotrophin receptor endocytosis and axonal growth...
  93. pmc Molecular organization and timing of Wnt1 expression define cohorts of midbrain dopamine neuron progenitors in vivo
    Ashly Brown
    Department of Neuroscience, Brown University, Providence, Rhode Island 02903, USA
    J Comp Neurol 519:2978-3000. 2011
    ..5 and E11.5. Collectively, our findings delineate the temporal window of MbDA neuron generation and show that lineage and timing predicts the terminal distribution pattern of MbDA neurons...
  94. doi Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons
    Frank M J Jacobs
    Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, UMC Utrecht, Utrecht, The Netherlands
    Development 138:5213-22. 2011
    ..Whereas all mdDA neurons require Nurr1 for expression of Th and survival, dependence on Pitx3 is displayed only by the mdDA subpopulation that will form the substantia nigra (..
  95. doi Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons
    Elisa J Hoekstra
    Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Neurosci 37:23-32. 2013
    ..Taken together, microarray analysis of an LMX1A-overexpression cell system resulted in the identification of novel direct or indirect downstream targets of Lmx1a in mdDA neurons: Grb10, Rgs4 and Vmat2...
  96. pmc Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2
    Elisa J Hoekstra
    Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e74049. 2013
    ....
  97. doi An O2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia
    Aida Platero-Luengo
    Departamento de Fisiologia Medica y Biofisica, Instituto de Biomedicina de Sevilla IBiS, Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, 41013 Seville, Spain
    Cell 156:291-303. 2014
    ..Thus, glomus cells not only acutely activate the respiratory center but also induce NSC-dependent CB hypertrophy necessary for acclimatization to chronic hypoxemia. ..
  98. ncbi Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development
    Q Y Zhou
    Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
    Nature 374:640-3. 1995
    ..Without further treatment, however, they die before weaning. We conclude that catecholamines are essential for mouse fetal development and postnatal survival...
  99. pmc Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
    O Saucedo-Cardenas
    Department of Cell Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 95:4013-8. 1998
    ..Taken together, these data indicate that Nurr1 is essential for both survival and final differentiation of ventral mesencephalic late dopaminergic precursor neurons into a complete dopaminergic phenotype...
  100. ncbi Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice
    M S Szczypka
    Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle 98195, USA
    Neuron 22:167-78. 1999
    Dopamine-deficient mice (DA-/- ), lacking tyrosine hydroxylase (TH) in dopaminergic neurons, become hypoactive and aphagic and die by 4 weeks of age...
  101. ncbi Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinted region of mouse chromosome 7
    R Kato
    Department of Integrated Genetics, National Institute of Genetics and Graduate University for Advanced Studies, Mishima, Shizuoka, Japan
    DNA Res 6:401-5. 1999
    ....

Research Grants9

  1. The Role of Id2 in Adult Neurogenesis
    MATTHEW HAVRDA; Fiscal Year: 2008
    ..These experiments are immediately relevant to realization of the therapeutic potential of these unique cells. [unreadable] [unreadable]..
  2. MAPPING OF ALCOHOL PREFERENCE GENES IN RQI STRAINS
    Csaba Vadasz; Fiscal Year: 2002
    ..Identification of a <1 cM region will allow the identification of candidate genes and ESTs. We will map each identified and confirmed QTL. ..
  3. PIONEER AXON GUIDANCE IN THE EMBRYONIC FOREBRAIN
    GRANT MASTICK; Fiscal Year: 2004
    ..In addition, the mechanisms of axon growth during development may give insight into how regeneration of the nervous system may be stimulated following trauma or disease. ..
  4. Role of Pitx2 in the Mammalian Central Nervous System
    Donna Martin; Fiscal Year: 2005
    ..5-14.5) mouse diencephalon, 2) Develop and analyze mice with Pitx2 loss of function, and 3) Develop and analyze transgenic mice with CNS-specific Pitx2 gain of function. ..
  5. Pitx2 Function in Developing Mouse Brain Neurons
    Donna M Martin; Fiscal Year: 2010
    ..These results will help guide future experiments aimed at directing neural stem cell differentiation toward specific neuronal cell subtypes. ..
  6. Longitudinal axon guidance by long range cues in the embryonic brain
    GRANT STEPHEN MASTICK; Fiscal Year: 2011
    ....