Tjp1

Summary

Gene Symbol: Tjp1
Description: tight junction protein 1
Alias: ZO1, tight junction protein ZO-1, zona occludens protein 1, zonula occludens protein 1
Species: mouse

Top Publications

  1. doi ZO-1 and the spatial organization of gap junctions and glutamate receptors in the outer plexiform layer of the mammalian retina
    Christian Puller
    Department of Neuroanatomy, Max Planck Institute for Brain Research, D 60528 Frankfurt, Germany
    J Neurosci 29:6266-75. 2009
  2. pmc Cell-autonomous requirements for Dlg-1 for lens epithelial cell structure and fiber cell morphogenesis
    Charlene Rivera
    Department of Anatomy, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Dev Dyn 238:2292-308. 2009
  3. pmc Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex
    Ronald S Bultje
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Neuron 63:189-202. 2009
  4. ncbi Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
  5. ncbi Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase
    Svetlana M Stamatovic
    Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Cell Sci 116:4615-28. 2003
  6. doi Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen
    Jerome Gilleron
    INSERM U 895, Team 5 Physiopathologic control of germ cell proliferation genomic and non genomic mechanisms, Universite Paris Descartes, 45 rue des Saint Peres, 75006, Paris, France
    J Cell Sci 121:4069-78. 2008
  7. pmc Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells
    Yanfang Guan
    Dept of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
    Am J Physiol Cell Physiol 300:C1404-14. 2011
  8. pmc Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1
    Anne Christine Hick
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    BMC Dev Biol 9:66. 2009
  9. ncbi Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis
    Lisa S Poritz
    Department of Surgery and Department of Pathology, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Surg Res 140:12-9. 2007
  10. doi Roles of ZO-1 and ZO-2 in establishment of the belt-like adherens and tight junctions with paracellular permselective barrier function
    Sachiko Tsukita
    Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Ann N Y Acad Sci 1165:44-52. 2009

Research Grants

Scientific Experts

Detail Information

Publications149 found, 100 shown here

  1. doi ZO-1 and the spatial organization of gap junctions and glutamate receptors in the outer plexiform layer of the mammalian retina
    Christian Puller
    Department of Neuroanatomy, Max Planck Institute for Brain Research, D 60528 Frankfurt, Germany
    J Neurosci 29:6266-75. 2009
    ..Based on this distinct spatial organization of gap junctions and GluRs, it is tempting to speculate that glutamate released from the photoreceptors may play a role in modulating the conductance of electrical synapses in the OPL...
  2. pmc Cell-autonomous requirements for Dlg-1 for lens epithelial cell structure and fiber cell morphogenesis
    Charlene Rivera
    Department of Anatomy, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Dev Dyn 238:2292-308. 2009
    ..These fiber cell defects were recapitulated when Dlg-1 was disrupted only in fiber cells. These results suggest that Dlg-1 acts in a cell autonomous manner to regulate epithelial cell structure and fiber cell differentiation...
  3. pmc Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex
    Ronald S Bultje
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Neuron 63:189-202. 2009
    ..These results reveal a critical molecular pathway underlying asymmetric cell division of radial glial progenitors in the mammalian neocortex...
  4. ncbi Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
    ..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs...
  5. ncbi Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase
    Svetlana M Stamatovic
    Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Cell Sci 116:4615-28. 2003
    ..These data are the first to strongly suggest that MCP-1, via CCR2 present on brain endothelial cells, contributes to increased brain endothelial permeability...
  6. doi Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen
    Jerome Gilleron
    INSERM U 895, Team 5 Physiopathologic control of germ cell proliferation genomic and non genomic mechanisms, Universite Paris Descartes, 45 rue des Saint Peres, 75006, Paris, France
    J Cell Sci 121:4069-78. 2008
    ....
  7. pmc Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells
    Yanfang Guan
    Dept of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
    Am J Physiol Cell Physiol 300:C1404-14. 2011
    ....
  8. pmc Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1
    Anne Christine Hick
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    BMC Dev Biol 9:66. 2009
    ..The morphogenic mechanisms by which the ductal network is established as well as the signaling pathways involved in this process are poorly understood...
  9. ncbi Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis
    Lisa S Poritz
    Department of Surgery and Department of Pathology, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Surg Res 140:12-9. 2007
    ..This study looked at the expression of the TJ protein ZO-1 and the corresponding permeability changes in dextran sulfate sodium (DSS) induced colitis in a mouse model...
  10. doi Roles of ZO-1 and ZO-2 in establishment of the belt-like adherens and tight junctions with paracellular permselective barrier function
    Sachiko Tsukita
    Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Ann N Y Acad Sci 1165:44-52. 2009
    ....
  11. pmc Connexin45-containing neuronal gap junctions in rodent retina also contain connexin36 in both apposing hemiplaques, forming bihomotypic gap junctions, with scaffolding contributed by zonula occludens-1
    Xinbo Li
    Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Neurosci 28:9769-89. 2008
    ..These data document that in Cx45-expressing neurons of IPL, Cx45 is almost always accompanied by Cx36, forming "bihomotypic" gap junctions, with Cx45 structurally coupling to Cx45 and Cx36 coupling to Cx36...
  12. pmc Association of connexin36 and zonula occludens-1 with zonula occludens-2 and the transcription factor zonula occludens-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retina
    C Ciolofan
    Department of Physiology, Faculty of Medicine, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada R3E 3J7
    Neuroscience 140:433-51. 2006
    ....
  13. ncbi Spatial relationships of connexin36, connexin57 and zonula occludens-1 in the outer plexiform layer of mouse retina
    C Ciolofan
    Department of Physiology, Faculty of Medicine, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada R3E 3J7
    Neuroscience 148:473-88. 2007
    ....
  14. pmc In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1
    Daniel Silberschmidt
    Stazione Zoologica Anton Dohrn, Villa Comunale, 80121, Napoli, Italy
    BMC Dev Biol 11:9. 2011
    ..We have generated mouse mutant strains to assess the roles of the two activation domains and of phosphorylation in mouse development and differentiation...
  15. pmc CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity
    Kentaro Nagaoka
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Commun 3:675. 2012
    ..Our data demonstrate that CPEB-mediated zonal occludens-1 mRNA localization is essential for tight-junction assembly and mammary epithelial cell polarity...
  16. ncbi Kidney development in cadherin-6 mutants: delayed mesenchyme-to-epithelial conversion and loss of nephrons
    S P Mah
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, 92037, USA
    Dev Biol 223:38-53. 2000
    ..These studies support the idea that cadherins play an essential role in the formation of epithelial structures and underscore the importance of timing in orchestrating the morphogenesis of complex epithelial tissues...
  17. ncbi Evidence for a functional interaction between cingulin and ZO-1 in cultured cells
    Fabio D'Atri
    Department of Molecular Biology, University of Geneva, 1211 Geneva 4, Switzerland
    J Biol Chem 277:27757-64. 2002
    ....
  18. doi Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis
    Yujuan Zheng
    Department of Oncology and Pathology, Cancer Centrum Karolinska, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Circ Res 105:260-70. 2009
    ..Angiomotin-like protein 1 (AmotL1) potentially compensates for the absence of Amot as it is 62% homologous to Amot and exhibits similar expression pattern in endothelial cells...
  19. ncbi Expression of the tight junction protein ZO-1 in the olfactory system: presence of ZO-1 on olfactory sensory neurons and glial cells
    F Miragall
    Institut fur Anatomie, Universitat Regensburg, Germany
    J Comp Neurol 341:433-48. 1994
    ..Our results provide further evidence that ZO-1 serves functions unrelated to the tight junction complex and indicate molecular heterogeneity of these cell-cell contacts...
  20. ncbi Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 alpha+ isoform
    B Sheth
    Division of Cell Sciences, School of Biological Sciences, University of Southampton, UK
    Development 124:2027-37. 1997
    ....
  21. ncbi Zonula occludens-1 and E-cadherin are coordinately expressed in the mouse uterus with the initiation of implantation and decidualization
    B C Paria
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas, 66160 7338, USA
    Dev Biol 208:488-501. 1999
    ....
  22. ncbi Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells
    P J Kausalya
    Institute of Molecular and Cell Biology, Epithelial Cell Biology Laboratory, Singapore
    FEBS Lett 505:92-6. 2001
    b>Zonula occludens protein 1 (ZO-1) is a cytosolic tight junction protein that tethers transmembrane proteins such as occludin, claudin and junctional adhesion molecule to the actin cytoskeleton...
  23. pmc Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice
    G Kostka
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    Mol Cell Biol 21:7025-34. 2001
    ..The data indicate a strong but restricted abnormality in some endothelial compartments which, together with some kidney and lung defects, may be responsible for early death...
  24. ncbi Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule
    Yoko Hamazaki
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 277:455-61. 2002
    ....
  25. ncbi Use of surface plasmon resonance for real-time analysis of the interaction of ZO-1 and occludin
    A Schmidt
    Institute of Molecular Pharmacology, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Biochem Biophys Res Commun 288:1194-9. 2001
    ..We demonstrate the use of SPR spectroscopy as an effective approach for characterisation of the interactions of junction proteins...
  26. pmc Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain
    X Li
    Department of Physiology, Faculty of Medicine, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada R3E 3J7
    Neuroscience 126:611-30. 2004
    ..Further, our findings suggest a scaffolding and/or regulatory role of ZO-1 at the oligodendrocyte side of astrocyte-to-oligodendrocyte gap junctions...
  27. ncbi Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development
    Maiko Inagaki
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Development 132:1525-37. 2005
    ....
  28. ncbi HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK 1/2 activation
    Hong Pu
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Surgery, University of Kentucky Medical Center, Kentucky 40536, USA
    J Cereb Blood Flow Metab 25:1325-35. 2005
    ..These results indicate that Tat-induced oxidative stress can play an important role in affecting the integrity of the BBB through the ERK 1/2 pathway...
  29. ncbi ZO-1 alters the plasma membrane localization and function of Cx43 in osteoblastic cells
    James G Laing
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 118:2167-76. 2005
    ..They suggest that ZO-1-mediated delivery of Cx43 from a lipid raft domain to gap junctional plaques may be an important regulatory step in gap junction formation...
  30. pmc Requirement of ZO-1 for the formation of belt-like adherens junctions during epithelial cell polarization
    Junichi Ikenouchi
    Department of Cell Biology, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 176:779-86. 2007
    ..The requirement for ZO-1 differs between belt-like AJ and TJ formation. We propose that ZO-1 is directly involved in the establishment of two distinct junctional domains, belt-like AJs and TJs, during epithelial polarization...
  31. ncbi Proteomic identification of ZO-1/2 as a novel scaffold for Src/Csk regulatory circuit
    Kazunobu Saito
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 366:969-75. 2008
    ..These results suggest novel roles for ZO proteins as Src/Csk scaffolds potentially involved in the regulation of Src transformation...
  32. pmc Regulation of cellular calcium in vestibular supporting cells by otopetrin 1
    Euysoo Kim
    Washington University School of Medicine, Department of Developmental Biology, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Neurophysiol 104:3439-50. 2010
    ..These data support a model in which OTOP1 acts as a sensor of the extracellular calcium concentration near supporting cells and responds to ATP in the endolymph to increase intracellular calcium levels during otoconia mineralization...
  33. pmc PLEKHA7 is an adherens junction protein with a tissue distribution and subcellular localization distinct from ZO-1 and E-cadherin
    Pamela Pulimeno
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    PLoS ONE 5:e12207. 2010
    ....
  34. pmc mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors
    C Meyer
    Zentrum für Biochemie und Molekulare Zellbiologie, Dept Biochemie II, Universitat Gottingen, Heinrich Düker Weg 12, D 37073 Gottingen, Germany
    EMBO J 19:2193-203. 2000
    ..MPR46 fails to recycle back from the endosome to the TGN, indicating that AP-1 is required for retrograde endosome to TGN transport of the receptor...
  35. pmc Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions
    M Furuse
    Department of Information Physiology, National Institute for Physiological Sciences, Okazaki, Aichi, Japan
    J Cell Biol 127:1617-26. 1994
    ..The coincidence of the sequence necessary for the ZO-1 association with that for the TJ localization suggests that the association with underlying cytoskeletons through ZO-1 is required for occludin to be localized at TJ...
  36. ncbi Expression and distribution of ZO-3, a tight junction MAGUK protein, in mouse tissues
    Akihito Inoko
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 8:837-45. 2003
    ..However, in contrast to ZO-1/ZO-2, our knowledge of the expression and distribution of ZO-3 is still fragmentary, partly due to a lack of antibodies that specifically distinguish ZO-3 from ZO-1 and ZO-2...
  37. pmc Early glomerular filtration defect and severe renal disease in podocin-deficient mice
    Séverine Roselli
    Inserm U574, Hopital Necker Enfants Malades, Universite Rene Descartes, Tour Lavoisier 6ème étage, 75743 Paris, France
    Mol Cell Biol 24:550-60. 2004
    ..was modified in Nphs2-/- kidneys: the expression of the nephrin gene was downregulated, whereas that of the ZO1 and CD2AP genes appeared to be upregulated...
  38. ncbi Establishment and characterization of cultured epithelial cells lacking expression of ZO-1
    Kazuaki Umeda
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 279:44785-94. 2004
    ..Finally, we discussed advantageous aspects of the gene knock-out system with cultured epithelial cells in epithelial cell biology...
  39. ncbi Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland
    Atsushi Hashizume
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan
    Dev Dyn 231:425-31. 2004
    ..These results will provide a valuable resource for further investigation of tubulogenesis and physiological regulation of claudin-based tight junctions...
  40. pmc Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells
    Tatsuya Katsuno
    Laboratory of Biological Science, Graduate School of Frontier Biosciences, and Graduate School of Medicine, Osaka University, Japan
    Mol Biol Cell 19:2465-75. 2008
    ..To investigate the role of ZO-1 (encoded by Tjp1) in vivo, ZO-1 knockout (Tjp1(-/-)) mice were generated by gene targeting...
  41. pmc MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex
    Karpagam Srinivasan
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Development 135:1781-90. 2008
    ..Our results suggest that MALS-3 plays a role in maintaining apicobasal polarity and is required for normal neurogenesis in the developing cortex...
  42. pmc Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse
    Hehai Wang
    Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, 1125 MRB IV, 2215 B Garland Avenue, Nashville, TN 37232 0656, USA
    Dev Biol 318:112-25. 2008
    ..These results provide the first evidence that ZO-1 is involved in blastocyst formation from the morula by regulating accumulation of fluid and differentiation of nonpolar blastomeres to polar trophoblast cells...
  43. pmc ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula adherens
    Yuji Yamazaki
    Laboratory of Biological Science, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Mol Biol Cell 19:3801-11. 2008
    ..Here, we immunofluorescently showed that myosin-2 failed to be integrated into the ZA in cultured epithelial-type ZO1(ko)/2(kd) Eph4 cells lacking ZO-1 and -2 (zonula occludens-1 and -2) by knockout and knockdown, respectively...
  44. doi Tight junction protein ZO-2 expression and relative function of ZO-1 and ZO-2 during mouse blastocyst formation
    Bhavwanti Sheth
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO167PX, UK
    Exp Cell Res 314:3356-68. 2008
    ..In contrast, ZO-1 knockdown, or combined ZO-1 and ZO-2 knockdown, generated a more severe inhibition of blastocoel formation indicating distinct roles for ZO proteins in blastocyst morphogenesis...
  45. ncbi ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate and synaptic cell junctions
    D F Woods
    Developmental Biology Center, University of California, Irvine 92717 2275
    Mech Dev 44:85-9. 1993
  46. pmc The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy
    M Itoh
    Department of Information Physiology, National Institute for Physiological Sciences, Aichi, Japan
    J Cell Biol 121:491-502. 1993
    ..Possible functions of the 220-kD protein (ZO-1) are discussed with special reference to the molecular mechanism for adherens and tight junction formation...
  47. ncbi Tight junction proteins
    S Citi
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    Biochim Biophys Acta 1448:1-11. 1998
  48. ncbi Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin
    M Itoh
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Biol Chem 274:5981-6. 1999
    ..These findings indicated that ZO-2 forms a complex with ZO-1/occludin or ZO-1/alpha catenin to establish TJ or AJ domains, respectively...
  49. pmc Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis
    W Ikeda
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Osaka 565 0871, Japan
    J Cell Biol 146:1117-32. 1999
    ....
  50. ncbi Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
    Dan Strumpf
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Ontario, Canada
    Development 132:2093-102. 2005
    ..Thus, Cdx2 is essential for segregation of the ICM and TE lineages at the blastocyst stage by ensuring repression of Oct4 and Nanog in the TE...
  51. ncbi Ca2+ dynamics in salivary acinar cells: distinct morphology of the acinar lumen underlies near-synchronous global Ca2+ responses
    Olga Larina
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    J Cell Sci 118:4131-9. 2005
    ..We suggest that this may be a structural adaptation in submandibular cells to support the copious amounts of fluid secreted...
  52. pmc Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells
    Elizabeth McNeil
    Center for Cell Signaling, Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908 0577
    Mol Biol Cell 17:1922-32. 2006
    ..These data reveal an unexpected function for the SH3 domain of ZO-1 in regulating tight junction assembly in epithelial cells and show that cingulin, occludin, or ZO-2 are not limiting for junction assembly in MDCK monolayers...
  53. ncbi PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains
    Tomonori Hirose
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, Yokohama 236 0004, Japan
    Development 133:1389-98. 2006
    ..By contrast, ZO1 and alpha4/beta1 integrins normally localize to cell-cell junctions and basal domains, respectively...
  54. ncbi ZO-1 expression and phosphorylation in diabetic nephropathy
    Hernan Rincon-Choles
    South Texas Veterans Health Care System, San Antonio, TX, USA
    Diabetes 55:894-900. 2006
    ..These findings suggest that alterations in the content and localization of ZO-1 may be relevant to the pathogenesis of proteinuria in diabetes...
  55. ncbi ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation
    Kazuaki Umeda
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Kyoto 606 8501, Japan
    Cell 126:741-54. 2006
    ..When NZO-1 was forcibly recruited to lateral membranes and dimerized, claudins were dramatically polymerized. These findings indicate that ZO-1 and ZO-2 can independently determine whether and where claudins are polymerized...
  56. pmc Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein
    Makoto Adachi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 26:9003-15. 2006
    ..These findings indicate that ZO-3 is dispensable in vivo in terms of individual viability, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment...
  57. ncbi Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm
    Natalia G Kan
    Max Planck Institut fur Immunbiologie, Abteilung für Molekulare Embryologie, Stubeweg 51, D 79108 Freiburg, Germany
    Development 134:31-41. 2007
    ..Thus, N-cadherin can maintain epithelia in differentiating ES cells, but not during the formation of the trophectoderm. Our results point to a specific and unique function for E-cadherin during mouse preimplantation development...
  58. ncbi Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties
    Yuko Sugihara-Mizuno
    Department of Cell Biology, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 12:473-86. 2007
    ....
  59. ncbi Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization
    Helen M Phillips
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    Circ Res 101:137-45. 2007
    ..We propose that heterozygosity for mutations in different genes in the planar cell polarity pathway may be an important mechanism for congenital heart defects and cardiomyopathy in humans...
  60. ncbi Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis
    Daijiro Konno
    Laboratory for Cell Asymmetry, Center for Developmental Biology, RIKEN, and CREST, Japan Science and Technology Corporation, RIKEN, 2 2 3 Minatojima minamimachi, Chuou ku, Kobe 650 0047, Japan
    Nat Cell Biol 10:93-101. 2008
    ..Our results suggest that planar mitosis ensures the self-renewal of neuroepithelial progenitors by one daughter inheriting both apical and basal compartments during neurogenesis...
  61. pmc Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development
    Jianliang Xu
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Republic of Singapore
    Mol Cell Biol 28:1669-78. 2008
    ..Thus, ZO-2 is required for mouse embryonic development, but ZO-3 is dispensable. This is to our knowledge the first report showing that an individual ZO protein plays a nonredundant and critical role in mammalian development...
  62. doi Differential requirement for beta-catenin in epithelial and fiber cells during lens development
    Sarah Cain
    Ocular Development Laboratory, Anatomy and Cell Biology Department, University of Melbourne, Victoria 3010, Australia
    Dev Biol 321:420-33. 2008
    ..cells displayed altered apical-basal polarity as evidenced by altered distribution of the tight junction protein, ZO1, disruption of apical actin filaments and abnormal deposition of extracellular matrix, resulting in a deficient ..
  63. pmc Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures
    Janice L Walker
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Dev Dyn 237:3128-41. 2008
    ....
  64. pmc Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2
    Alysia L VandenBerg
    Universite Pierre et Marie Curie Paris VI, 75634 Paris Cedex 13, France
    Development 136:1559-70. 2009
    ..These studies demonstrate that the establishment and maintenance of cell polarity through non-canonical Wnt signaling are required for FRT development...
  65. pmc Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression
    Peter Westenskow
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Development 136:2505-10. 2009
    ....
  66. pmc MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function
    Dan Yu
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:8237-41. 2010
    ..These data demonstrate a critical role for the ZO-1 ABR in barrier function and suggest that MLCK-dependent ZO-1 exchange is essential to this mechanism of barrier regulation...
  67. doi Extracellular domain of V-set and immunoglobulin domain containing 1 (VSIG1) interacts with sertoli cell membrane protein, while its PDZ-binding motif forms a complex with ZO-1
    Ekyune Kim
    National Primate Research Center, Korea Research Institute of Biotechnology, Ochang, 363 883, Korea
    Mol Cells 30:443-8. 2010
    ..Our findings suggest that mouse VSIG1 interacts with Sertoli cells by heterophilic adhesion via its first Ig-like domain. In addition, its cytoplasmic domain is critical for binding to ZO-1...
  68. doi CD44 regulates tight-junction assembly and barrier function
    Nina Kirschner
    Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Invest Dermatol 131:932-43. 2011
    ..Taken together, the results reveal an important function for CD44 in the assembly and function of TJs, suggesting their involvement in the skin barrier phenotype of CD44 KO mice...
  69. pmc Localization of AQP5 during development of the mouse submandibular salivary gland
    Helga S Larsen
    Department of Oral Biology, Faculty of Dentistry, University of Oslo, Sognsvannsveien 10, Rikshospitalet, Blindern, Post Box 1052, 0316 Oslo, Norway
    J Mol Histol 42:71-81. 2011
    ..These results demonstrate an evolving distribution of AQP5 during pre- and postnatal development in the mouse SMGs...
  70. pmc The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice
    Anastasios Georgiadis
    Department of Genetics, UCL Institute of Ophthalmology, University College London, London, United Kingdom
    PLoS ONE 5:e15730. 2010
    ....
  71. doi ZO-1 regulates Erk, Smad1/5/8, Smad2, and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells
    Jianliang Xu
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, Singapore
    Stem Cells 30:1885-900. 2012
    ZO-1/Tjp1 is a cytosolic adaptor that links tight junction (TJ) transmembrane proteins to the actin cytoskeleton and has also been implicated in regulating cell proliferation and differentiation by interacting with transcriptional ..
  72. ncbi The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1
    Sebastian L Müller
    Forschungsinstitut fur Molekulare Pharmakologie, 13125 Berlin, Charite Campus Mitte, 10117 Berlin, Germany, and Charité Campus Benjamin Franklin, 12203 Berlin, Germany
    J Biol Chem 280:3747-56. 2005
    ....
  73. ncbi Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins
    Vincent C Chen
    Department of Chemistry, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada
    J Proteome Res 5:2123-34. 2006
    ....
  74. ncbi Mouse embryonic submandibular gland epithelium loses its tissue integrity during early branching morphogenesis
    Y Hieda
    Department of Biology, Graduate School of Science, Osaka University, Japan
    Dev Dyn 207:395-403. 1996
    ....
  75. ncbi Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain
    Mihai C Penes
    Department of Physiology, Faculty of Medicine, University of Manitoba, 730 William Ave, Winnipeg, Manitoba R3E 3J7, Canada
    Eur J Neurosci 22:404-18. 2005
    ..Given previous observations that ZONAB and ZO-1 in combination regulate gene expression, our results suggest roles of glial gap junction-mediated anchoring of signalling molecules in a wide variety of glial homeostatic processes...
  76. ncbi HIF activation and VEGF overexpression are coupled with ZO-1 up-phosphorylation in the brain of dystrophic mdx mouse
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Brain Pathol 17:399-406. 2007
    ....
  77. doi NHS-A isoform of the NHS gene is a novel interactor of ZO-1
    Shiwani Sharma
    Department of Ophthalmology, Flinders University, Bedford Park, SA 5042, Australia
    Exp Cell Res 315:2358-72. 2009
    ..In conclusion, the NHS-A isoform of NHS is a novel interactor of ZO-1 and may have a role at tight junctions. This isoform is important in mammalian development especially of the organs in the head...
  78. ncbi Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development
    A B Zhadanov
    McLaughlin Research Institute, 1520 23rd Street South, Great Falls, Montana 59405 4900, USA
    Curr Biol 9:880-8. 1999
    ..As cell-cell junctions are important in morphogenesis, we generated a null mutation in the murine Af6 locus to test the hypothesis that lack of AF-6 function would cause epithelial abnormalities...
  79. pmc Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
    M Itoh
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 147:1351-63. 1999
    ..In good agreement, PDZ1 and PDZ2 domains of ZO-1/ZO-2/ZO-3 were also recruited to claudin-based TJs, when introduced into cultured epithelial cells. The possible molecular architecture of TJ plaque structures is discussed...
  80. pmc Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin
    M Cordenonsi
    Department of Biology, University of Padova, 35121 Padova, Italy
    J Cell Biol 147:1569-82. 1999
    ..We propose that cingulin is a functionally important component of TJ, linking the submembrane plaque domain of TJ to the actomyosin cytoskeleton...
  81. ncbi Nectin-dependent localization of ZO-1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus
    Maiko Inagaki
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    J Comp Neurol 460:514-24. 2003
    ..These results indicate that ZO-1 colocalizes with nectin and afadin at the PAs and that the nectin-afadin system is involved in the localization of ZO-1...
  82. ncbi Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney
    Eman Naim
    Department of Anatomy and Cell Biology, Monash University, Clayton, Victoria, Australia
    Kidney Int 68:955-65. 2005
    ..The aim of this study was to investigate the role of the epithelial polarity gene, discs large 1 (dlg1), during development of the mouse kidney...
  83. doi Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged
    Isabelle Plante
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Biol Reprod 82:837-47. 2010
    ....
  84. pmc Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation
    Li Chin Yao
    Department of Anatomy, Cardiovascular Research Institute, and the Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Am J Pathol 180:2561-75. 2012
    ..These findings demonstrate the plasticity of intercellular junctions in lymphatics during development and inflammation and show that button formation can be promoted by glucocorticoid receptor signaling in lymphatic endothelial cells...
  85. doi Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, CH 1211 Geneva, Switzerland
    J Cell Sci 125:5005-14. 2012
    ....
  86. pmc Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ε-mediated zona occludens-1 phosphorylation at threonine 770/772
    Rima Chattopadhyay
    From the Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163
    J Biol Chem 289:3148-63. 2014
    ....
  87. doi Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates
    Jun Hatakeyama
    Department of Brain Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Chuo Ku, Kumamoto 860 0811, Japan
    Development 141:1671-82. 2014
    ..Our results identified the apical endfoot as the central site of active Notch signaling to securely prohibit inappropriate differentiation of neural progenitors. ..
  88. pmc A dual role for planar cell polarity genes in ciliated cells
    Camille Boutin
    Institute of Neuroscience, Developmental Neurobiology, Universite Catholique de Louvain, B1200 Brussels, Belgium
    Proc Natl Acad Sci U S A 111:E3129-38. 2014
    ..Loss of either of these signals is associated with specific defects in the cytoskeleton. Our data reveal unreported functions of PCP and provide an integrated view of planar polarization of the brain ciliated cells. ..
  89. pmc Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response
    Christoph Schell
    Renal Division, University Medical Center Freiburg, Freiburg, Germany Spemann Graduate School of Biology and Medicine SGBM, Albert Ludwigs University Freiburg, Freiburg, Germany Faculty of Biology, Albert Ludwigs University Freiburg, Freiburg, Germany
    PLoS ONE 10:e0129424. 2015
    ..Thus these data indicate that in contrast to lower vertebrate models, mammalian podocytes have acquired molecular programs to compensate for the loss of Cxadr. ..
  90. pmc Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo
    Kristina Preuße
    Institut für Molekularbiologie OE5250, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS Genet 11:e1005328. 2015
    ..These differential cis-inhibitory properties are likely to contribute to the functional divergence of DLL1 and DLL4. ..
  91. pmc The endocytic recycling regulatory protein EHD1 Is required for ocular lens development
    Priyanka Arya
    Department of Genetics, Cell Biology and Anatomy, College of Medicine, University of Nebraska Medical Center, 985805 Nebraska Medical Center Omaha, NE 68198 5805, USA Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, NE 68198 5950, USA Electronic address
    Dev Biol 408:41-55. 2015
    ....
  92. pmc Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development
    Bertha C Elias
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Sci 128:4293-305. 2015
    ..Thus, we conclude that the principal role of Cdc42 in ureteric bud and metanephric mesenchyme development is to regulate epithelial cell polarity and the actin cytoskeleton...
  93. pmc Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo
    Lucie E Charrier
    Departement de Biologie Moleculaire, Biochimie Médicale et Pathologie Centre de Recherche sur le Cancer, Universite Laval, Quebec, Canada
    Sci Rep 5:17699. 2015
    ....
  94. ncbi The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse
    H R MacDonald
    Department of Medical Genetics, University of Alberta, Edmonton, Canada
    Hum Mol Genet 6:1873-8. 1997
    ..NDN is expressed exclusively from the paternally inherited allele in human fibroblasts. Loss of necdin gene expression may contribute to the disorder of brain development in individuals with PWS...
  95. ncbi The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye
    S H Kidson
    Department of Anatomy and Cell Biology, University of Cape Town, Observatory, 7925, South Africa
    Dev Biol 211:306-22. 1999
    ..layer, as judged by electron microscopy and by absence of labeling with monoclonal antibody to zonula occludens protein 1, a normal component of occluding junctions in wild-type endothelial cells...
  96. ncbi The murine gene, Traube, is essential for the growth of preimplantation embryos
    T Thomas
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, Goettingen, 37077, Germany
    Dev Biol 227:324-42. 2000
    ..This paucity of ribosomes together with the localization of TRB to the nucleoli, the site of ribosome synthesis, suggests that TRB is involved in the synthesis of ribosomes...
  97. ncbi Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization
    Amel Gritli-Linde
    Department of Oral Biochemistry, Sahlgrenska Academy at Goteborg University, Sweden
    Development 129:5323-37. 2002
    ..Furthermore, we provide evidence that Shh signaling between ameloblasts and the overlying stratum intermedium may involve subcellular localization of Patched 2 and Gli1 mRNAs, both of which are targets of Shh signaling in these cells...
  98. ncbi Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, 85724, USA
    Dev Biol 251:206-20. 2002
    ..These results provide evidence of a critical role for endothelial gap junction-mediated communication in the development and/or functional maintenance of segments of the mouse vasculature...
  99. ncbi Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development
    Vladimir V Kalinichenko
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois, Chicago, IL 60607 7170, USA
    Am J Physiol Lung Cell Mol Physiol 286:L521-30. 2004
    ..Foxf1 haploinsufficiency disrupted pulmonary expression of genes in the Notch-2-signaling pathway and resulted in abnormal development of lung microvasculature...
  100. ncbi Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo
    Noriko Okabe
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka, Japan
    Dev Dyn 230:174-86. 2004
    ..These results suggest that nectins and afadin are involved in dynamic epithelial remodeling during mouse development...

Research Grants4

  1. GAP JUNCTIONAL COMMUNICATION IN LENS FUNCTION
    Nalin Kumar; Fiscal Year: 2001
    ..The generation of these knockout mice will also provide a unique opportunity to identify small biologically relevant molecules that may be transmitted via gap junctional communication to influence the process of cataract formation. ..
  2. THE ROLE OF SRF IN CARDIAC FUNCTION AND DEVELOPMENT
    RAVINDRA MISRA; Fiscal Year: 2005
    ..These studies will both elucidate the mechanisms by which SRF functions in heart and will establish powerful new methodologies for studying heart formation and function. ..
  3. The Role of ZO-1 in the Function of Lens Gap Junctions
    Nalin Kumar; Fiscal Year: 2006
    ..These studies will enhance our knowledge of the processes and mechanisms that are required for regulation of gap junctions channels in the normal physiology of the lens and during cataractogenesis. ..
  4. Transcriptional Control of Early Coronary Vascular Development
    RAVINDRA P MISRA; Fiscal Year: 2010
    ....