Tlr7

Summary

Gene Symbol: Tlr7
Description: toll-like receptor 7
Alias: toll-like receptor 7, Toll like receptor 7
Species: mouse

Top Publications

  1. pmc Recognition of single-stranded RNA viruses by Toll-like receptor 7
    Jennifer M Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:5598-603. 2004
  2. pmc Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
    Cevayir Coban
    Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Agency JST, Osaka, Japan
    J Exp Med 201:19-25. 2005
  3. ncbi TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway
    J Moisan
    Department of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 290:L987-95. 2006
  4. pmc Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
    Jonathan A Deane
    Laboratory of Immunogenetics, NIAID NIH, Rockville, MD 20852, USA
    Immunity 27:801-10. 2007
  5. ncbi Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    Hiroaki Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 3:196-200. 2002
  6. ncbi Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 303:1529-31. 2004
  7. pmc Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    Franck J Barrat
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    J Exp Med 202:1131-9. 2005
  8. ncbi TLR3-, TLR7-, and TLR9-mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells
    Hironori Matsushima
    Department of Dermatology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Tamaho, Nakakoma, Yamanashi 409 3898, Japan
    J Immunol 173:531-41. 2004
  9. pmc The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
    Melanie M Brinkmann
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142
    J Cell Biol 177:265-75. 2007
  10. doi Emerging roles of TLR7 and TLR9 in murine SLE
    Marie Laure Santiago-Raber
    Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, 1211 Geneva 4, Switzerland
    J Autoimmun 33:231-8. 2009

Research Grants

Scientific Experts

Detail Information

Publications134 found, 100 shown here

  1. pmc Recognition of single-stranded RNA viruses by Toll-like receptor 7
    Jennifer M Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:5598-603. 2004
    ..These genomic nucleic acids serve as molecular signatures associated with viral infections. Here we show that TLR7 recognizes the single-stranded RNA viruses, vesicular stomatitis virus and influenza virus...
  2. pmc Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
    Cevayir Coban
    Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Agency JST, Osaka, Japan
    J Exp Med 201:19-25. 2005
    ..were severely impaired in TLR9-/- and myeloid differentiation factor 88 (MyD88)-/-, but not in TLR2, TLR4, TLR7, or Toll/interleukin 1 receptor domain-containing adaptor-inducing interferon beta-/- mice...
  3. ncbi TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway
    J Moisan
    Department of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 290:L987-95. 2006
    ..of mice sensitized and challenged with ovalbumin, we show that treatment with a synthetic Toll-like receptor 7 (TLR7) ligand (S-28463, a member of the imidazoquinoline family) prevents development of the asthmatic phenotype...
  4. pmc Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
    Jonathan A Deane
    Laboratory of Immunogenetics, NIAID NIH, Rockville, MD 20852, USA
    Immunity 27:801-10. 2007
    Nucleic acid-binding innate immune receptors such as Toll-like receptor 7 (TLR7) and TLR9 have been implicated in the development of some autoimmune pathologies...
  5. ncbi Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    Hiroaki Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 3:196-200. 2002
    ..Here we show that the imidazoquinolines activate immune cells via the Toll-like receptor 7 (TLR7)-MyD88-dependent signaling pathway...
  6. ncbi Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 303:1529-31. 2004
    ..that this requires endosomal recognition of influenza genomic RNA and signaling by means of Toll-like receptor 7 (TLR7) and MyD88...
  7. pmc Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    Franck J Barrat
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    J Exp Med 202:1131-9. 2005
    ..These ODNs include inhibitors of TLR9, inhibitors of TLR7 but not TLR9, and sequences that inhibit both TLR7 and TLR9...
  8. ncbi TLR3-, TLR7-, and TLR9-mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells
    Hironori Matsushima
    Department of Dermatology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Tamaho, Nakakoma, Yamanashi 409 3898, Japan
    J Immunol 173:531-41. 2004
    ..Although TLR2 and TLR4 mRNA were detected in both cells at comparable levels, TLR3, TLR7, and TLR9 mRNA were expressed by FSMC at higher levels than by BMMC, suggesting distinct TLR expression profiles ..
  9. pmc The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
    Melanie M Brinkmann
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142
    J Cell Biol 177:265-75. 2007
    ..Further, by expressing chimeric TLRs, we show that TLR3 and 9 bind to UNC93B via their transmembrane domains. We propose that a physical association between UNC93B and TLRs in the ER is essential for proper TLR signaling...
  10. doi Emerging roles of TLR7 and TLR9 in murine SLE
    Marie Laure Santiago-Raber
    Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, 1211 Geneva 4, Switzerland
    J Autoimmun 33:231-8. 2009
    ..Moreover, recent studies revealed that the innate receptors TLR7 and TLR9 are critically involved in the activation of dendritic cells and autoreactive B cells through the ..
  11. ncbi Cell type-specific involvement of RIG-I in antiviral response
    Hiroki Kato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Immunity 23:19-28. 2005
    ..In contrast, plasmacytoid DCs, which produce large amounts of IFN-alpha, use the TLR system rather than RIG-I for viral detection. Taken together, RIG-I and the TLR system exert antiviral responses in a cell type-specific manner...
  12. ncbi Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 177:7114-21. 2006
    b>TLR7 senses RNA in endosomal compartments. TLR7 expression and signaling have been demonstrated in plasmacytoid and myeloid dendritic cells, B cells, and T cells...
  13. ncbi Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon
    Luisa Cervantes-Barragan
    Research Department, Kantonal Hospital St Gallen, Switzerland, and Abeteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany
    Blood 109:1131-7. 2007
    ..Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following encounter with this cytopathic RNA virus...
  14. ncbi Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK
    Eur J Immunol 36:3256-67. 2006
    Toll-like receptor 7 (TLR7) mediates innate responses by responding to viral RNA in endocytic compartments. However, the molecular pattern recognised by TLR7 and whether it differs between RNA of viral and self origin remains unclear...
  15. pmc Toll-like receptor-mediated activation of neutrophils by influenza A virus
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Blood 112:2028-34. 2008
    ..using single-cell analysis of intracellular cytokine accumulation in neutrophils from knockout mice, we prove that TLR7 is essential for influenza viral recognition and inflammatory cytokine production by murine neutrophils...
  16. pmc Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases
    Bruce Beutler
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 227:248-63. 2009
    ..We have also developed some insight into critical points at which feedback loops can be interrupted...
  17. ncbi Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo
    Tobias Warger
    Institute for Immunology, Johannes Gutenberg University, Mainz, Germany
    Blood 108:544-50. 2006
    ..We observed that indeed the combined activation of MyD88-dependent and -independent signaling induced by TLR7 and TLR3 ligands provoked a more rapid and more sustained bone marrow-derived DC (BMDC) activation with regard to ..
  18. doi Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology
    Stefan Baenziger
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland
    Blood 113:377-88. 2009
    ..Thus, we hypothesized that sustained TLR7 triggering induces chronic immune activation and thereby contributes to progressive immunodeficiency...
  19. doi Influenza A infection enhances cross-priming of CD8+ T cells to cell-associated antigens in a TLR7- and type I IFN-dependent fashion
    Joe Wei
    Ludwig Institute for Cancer Research, Austin Health, Heidelberg, Melbourne, Victoria, Australia
    J Immunol 185:6013-22. 2010
    ..This enhanced cross-priming in part involves TLR7- but not TLR3-mediated sensing of IAV and is entirely dependent on MyD88 and IFN signaling pathways...
  20. pmc TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610, USA
    J Exp Med 205:2995-3006. 2008
    ..In vitro studies revealed that TMPD augments the effect of TLR7 ligands but does not directly activate TLR7 itself...
  21. pmc Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop
    Nathaniel M Green
    Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 183:1569-76. 2009
    ..In comparison to wild-type B cells, TLR7-stimulated IFNAR(-/-) B cells proliferated significantly less well and did not up-regulate costimulatory molecules...
  22. doi Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses
    Juliana Bessa
    Cytos Biotechnology AG, Zurich Schlieren, Switzerland
    J Immunol 183:3788-99. 2009
    ..Using virus-like particles loaded with single-stranded RNA as a ligand for TLR7, we found that systemic vs mucosal IgA responses in mice were differently regulated...
  23. ncbi Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice
    Robert Berland
    Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Immunity 25:429-40. 2006
    ..This autoantibody production was largely dependent on Toll-like receptor 7 (TLR7). We further show that production of these autoantibodies was sufficient to cause kidney pathology in these mice...
  24. ncbi Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production
    Kei Yasuda
    Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 178:6876-85. 2007
    ..This activation is only seen in sera with reactivity against ribonucleoproteins and is completely dependent on TLR7 and the presence of RNA...
  25. doi Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9
    Stefan Bauer
    Institut fur Immunology, Philipps Universitat Marburg, BMFZ, Hans Meerweinstr 2, 35043 Marburg, Germany
    Immunobiology 213:315-28. 2008
    ..b>TLR7-9 recognize single-stranded RNA, nucleoside analogs and single-stranded CpG-DNA, respectively, and their activation ..
  26. pmc Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7
    Tomoko Hayashi
    Rebecca and John Moores Cancer Center, University of California, San Diego, La Jolla, California, CA, USA
    Am J Physiol Regul Integr Comp Physiol 295:R123-32. 2008
    ..However, the physiological consequences of TLR7 activation have not been thoroughly studied...
  27. ncbi Analysis of the neuroinflammatory response to TLR7 stimulation in the brain: comparison of multiple TLR7 and/or TLR8 agonists
    Niranjan B Butchi
    Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
    J Immunol 180:7604-12. 2008
    ..b>TLR7 and TLR8 were identified as eliciting antiviral effects when stimulated by viral ssRNA...
  28. doi Pathogen recognition in the innate immune response
    Himanshu Kumar
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem J 420:1-16. 2009
    ..In the present review, we will discuss the recent progress in the study of pathogen recognition by TLRs, RLRs and NLRs and their signalling pathways...
  29. ncbi Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
    Marion Jurk
    Nat Immunol 3:499. 2002
  30. ncbi High-throughput engineering of the mouse genome coupled with high-resolution expression analysis
    David M Valenzuela
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill Road, Tarrytown, New York 10591, USA
    Nat Biotechnol 21:652-9. 2003
    ..5-1.0% of the entire genome. We also provide dozens of informative expression patterns involving cells in the nervous system, immune system, vasculature, skeleton, fat and other tissues...
  31. pmc RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
    Christina M Lau
    Department of Microbiology, Boston University School of Medicine, MA 02118, USA
    J Exp Med 202:1171-7. 2005
    ..We demonstrate that this two-receptor paradigm can be extended to the BCR/TLR7 activation of autoreactive B cells by RNA and RNA-associated autoantigens...
  32. pmc Activation of anti-hepatitis C virus responses via Toll-like receptor 7
    Jongdae Lee
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0663, USA
    Proc Natl Acad Sci U S A 103:1828-33. 2006
    ..Here we present evidence showing that a ligand of Toll-like receptor 7 (TLR7) can induce anti-HCV immunity not only by IFN induction, but also through an IFN-independent mechanism...
  33. ncbi TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses
    Alex K Heer
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    J Immunol 178:2182-91. 2007
    ..Surprisingly, TLR7 and MyD88 also played negligible roles in T cell activation and effector function upon infection with influenza ..
  34. ncbi Natural and synthetic TLR7 ligands inhibit CpG-A- and CpG-C-oligodeoxynucleotide-induced IFN-alpha production
    Beate Berghöfer
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Langhanstrasse 7, Giessen, Germany
    J Immunol 178:4072-9. 2007
    ..cells (pDCs) are unique with respect to their capacity to produce unsurpassed amounts of IFN-alpha and coexpress TLR7 and TLR9, mediating IFN-alpha production...
  35. pmc Murine cerebral malaria development is independent of toll-like receptor signaling
    Dieudonnée Togbe
    Molecular Immunology and Embryology, Centre National de la Recherche Scientifique, and University of Orleans, Transgenose Institute, Orleans, France
    Am J Pathol 170:1640-8. 2007
    ..However, TLR-dependent activation of innate immunity is unlikely to contribute significantly to the proinflammatory response to PbA infection and the development of fatal CM...
  36. pmc Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
    Mark E Kleinman
    Department of Ophthalmology, University of Kentucky, Lexington, Kentucky 40506, USA
    Nature 452:591-7. 2008
    ....
  37. pmc The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
    Sarah E Ewald
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, 405 Life Sciences Addition, Berkeley, California 94720 3200, USA
    Nature 456:658-62. 2008
    ..The localization of TLR9 and TLR7 to intracellular compartments seems to have a role in facilitating responses to viral nucleic acids while ..
  38. pmc Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7
    Tomoko Hayashi
    Moores Cancer Center, and Department Medicine, University California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:2764-9. 2009
    ..Here, we used a synthetic TLR7 agonist, 9-benzyl-8-hydroxy-2-(2-methoxyethoxy) adenine (SM360320, 1V136) to study TLR7 induced attenuation of ..
  39. pmc Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78
    Melanie L Conrad
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, 35043 Marburg, Germany
    J Exp Med 206:2869-77. 2009
    ..lwoffii F78-exposed mothers. These data establish a direct relationship between maternal bacterial exposures, functional maternal TLR signaling, and asthma protection in the progeny...
  40. doi Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells
    Katsuaki Hoshino
    Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Graduate School of Nanobioscience, Yokohama City University, Yokohama, Japan
    J Immunol 184:3341-5. 2010
    A plasmacytoid dendritic cell (DC) can produce large amounts of type I IFNs after sensing nucleic acids through TLR7 and TLR9...
  41. doi A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity
    Kosuke Fujimoto
    Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565 0871, Japan
    J Immunol 186:6287-95. 2011
    ..CD103(+)CD8α(+) LPDCs expressed TLR3, TLR7, and TLR9 and produced IL-6 and IL-12p40, but not TNF-α, IL-10, or IL-23, following TLR ligand stimulation...
  42. pmc A West Nile virus NS4B-P38G mutant strain induces adaptive immunity via TLR7-MyD88-dependent and independent signaling pathways
    Guorui Xie
    Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Vaccine 31:4143-51. 2013
    ..mutant infection in myeloid differentiation factor 88-deficient (MyD88(-/-)) and Toll-like receptor 7-deficient (TLR7(-/-)) mice and found they had enhanced susceptibility compared to wild-type mice...
  43. ncbi Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    Florian Heil
    Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
    Science 303:1526-9. 2004
    ..By using Toll-like receptor (TLR)-deficient mice and genetic complementation, we show that murine TLR7 and human TLR8 mediate species-specific recognition of GU-rich ssRNA...
  44. pmc Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565 0871, Japan
    J Exp Med 201:915-23. 2005
    ..Among TLR family members, TLR7, TLR8, and TLR9 induce interferon (IFN)-alpha in plasmacytoid dendritic cells (pDCs)...
  45. ncbi TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements
    Tadashi Nishiya
    Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    J Biol Chem 280:37107-17. 2005
    Toll-like receptor (TLR) 3 and TLR7 are indispensable for host defense against viral infection by recognizing virus-derived RNAs and are localized to intracellular membranes via an unknown mechanism...
  46. ncbi U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7
    Emina Savarese
    Department of Internal Medicine, Technical University Munich, Germany
    Blood 107:3229-34. 2006
    ..by U1snRNPs in murine bone marrow-derived PDCs required the presence of intact U1RNA and was largely dependent on Tlr7 but independent of Tlr3...
  47. ncbi IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9
    Katsuaki Hoshino
    Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Suehiro cho 1 7 22, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Nature 440:949-53. 2006
    ..b>TLR7/9-mediated dendritic cell activation is critical for antiviral immunity but also contributes to the pathogenesis of ..
  48. ncbi Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication
    Prapaporn Pisitkun
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases NIAID, NIH, Rockville, MD 20852, USA
    Science 312:1669-72. 2006
    ..accelerator (Yaa) locus are intrinsically biased toward nucleolar antigens because of increased expression of TLR7, a single-stranded RNA-binding innate immune receptor...
  49. ncbi Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    Sean R Christensen
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Immunity 25:417-28. 2006
    ..We report that lupus-prone mice deficient in TLR7, a receptor for ssRNA, failed to generate Abs to RNA-containing antigens (Ags) such as Smith (Sm) Ag...
  50. ncbi Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA
    Thirumala Devi Kanneganti
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:36560-8. 2006
    ..These results identify a mechanism mediated by cryopyrin and ASC that links dsRNA and viral infection to caspase-1 activation resulting in IL-1beta and IL-18 production...
  51. ncbi Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA
    Jennifer P Wang
    Department of Medicine, University of Massachusetts, 364 Plantation, Worcester, MA 01605, USA
    J Immunol 178:3363-7. 2007
    b>TLR7 recognizes the genome of ssRNA viruses such as Coxsackievirus B. Because TLR7 is expressed in intracellular compartments, viral RNA must be internalized before its recognition by TLR7...
  52. ncbi Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination
    Shohei Koyama
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka, Japan
    J Immunol 179:4711-20. 2007
    ..Moreover, vaccination of TLR7- and MyD88-deficient mice with inactivated virus failed to confer protection against a lethal live virus challenge...
  53. ncbi TLR3 and TLR7 are involved in expression of IL-23 subunits while TLR3 but not TLR7 is involved in expression of IFN-beta by Theiler's virus-infected RAW264.7 cells
    Fahd Al-Salleeh
    Department of Oral Biology, University of Nebraska Medical Center, 40th and Holdrege Streets, Lincoln, NE 68583 0740, USA
    Microbes Infect 9:1384-92. 2007
    ..Because TMEV may induce macrophages' cytokines through TLR3 and TLR7 (toll-like receptors), their role in TMEV-induced IL-23 and IFN-beta expression by the RAW264...
  54. ncbi Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids
    Christophe Paget
    Institut National de la Recherche Médicale, U547, 59019 Lille, France
    Immunity 27:597-609. 2007
    ..Together with the lipopolysaccharide-detecting receptor TLR4, activation of the nucleic acid sensors TLR7 and TLR9 in DCs were particularly potent in stimulating iNKT cells to produce IFN-gamma, but not IL-4...
  55. doi UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
    You Me Kim
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 452:234-8. 2008
    ..UNC93B1, essential for signalling of TLR3, TLR7 and TLR9 in both humans and mice, physically interacts with these TLRs in the endoplasmic reticulum (ER)...
  56. ncbi Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses
    Alexandra Forsbach
    Coley Pharmaceutical GmbH, Dusseldorf, Germany
    J Immunol 180:3729-38. 2008
    ..U-rich RNA sequences were recently discovered that stimulate human TLR7/8-mediated or murine TLR7-mediated immune effects...
  57. ncbi Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection
    Nicolas Zucchini
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Parc Scientifique de Luminy, Marseille Cedex 09, France
    J Immunol 180:5799-803. 2008
    ..In this study we show that TLR7 and TLR9 exert redundant functions for IFN-alpha/beta, IL-12p40, and TNF-alpha production by pDCs in vivo during ..
  58. pmc Yaa autoimmune phenotypes are conferred by overexpression of TLR7
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eur J Immunol 38:1971-8. 2008
    ..as many as 16 genes, the major candidate gene for causation of the Yaa-associated autoimmune phenotypes has been TLR7. To confirm the role of TLR7 in Yaa-mediated autoimmune phenotypes, we introgressed a targeted disruption of TLR7 (..
  59. doi Toll-like receptor 7 is not necessary for retroviral neuropathogenesis but does contribute to virus-induced neuroinflammation
    Stephanie D Lewis
    Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA
    J Neurovirol 14:492-502. 2008
    Toll-like receptor 7 (TLR7) recognizes guanidine-rich single-stranded (ss) viral RNA and is an important mediator of peripheral immune responses to several ssRNA viruses...
  60. pmc Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing
    Terrence Town
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 30:242-53. 2009
    ..We investigated Toll-like receptor 7-deficient (Tlr7(-/-)) and myeloid differentiation factor 88-deficient (Myd88(-/-)) mice, which both have defective recognition of ..
  61. doi Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells
    Giuseppe Mancuso
    The Elie Metchnikoff Department, University of Messina, Messina, Italy
    Nat Immunol 10:587-94. 2009
    ..Thus, this cell type-specific recognition pathway links lysosomal recognition of bacterial RNA with a robust, host-protective interferon response...
  62. pmc Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing
    Ryutaro Fukui
    Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Tokyo 108 8639, Japan
    J Exp Med 206:1339-50. 2009
    ..b>TLR7/9 in dendritic cells (DCs) also respond to self-derived RNA/DNA, respectively, and drive autoantibody production...
  63. doi Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice
    Marie Laure Santiago-Raber
    Department of Pathology and Immunology, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Autoimmun 34:339-48. 2010
    Accumulating evidence supports the idea that TLR7 and TLR9 play pathogenic and protective roles, respectively, in the development of murine systemic lupus erythematosus (SLE)...
  64. pmc Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists
    Deepa Rajagopal
    King s College London, Peter Gorer Department of Immunobiology, Guy s Hospital, London, United Kingdom
    Blood 115:1949-57. 2010
    ..The successful application of the TLR7 agonist R837 for treatment of basal cell carcinoma shows the potential for exploiting this pathway in tumor ..
  65. pmc TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus
    Kevin M Nickerson
    Department of Laboratory Medicine, Yale University, New Haven, CT 06519, USA
    J Immunol 184:1840-8. 2010
    ..We previously found that Tlr7 was required for anti-Sm and Tlr9 for anti-chromatin autoantibodies...
  66. doi Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner
    Juliana Bessa
    Cytos Biotechnology, Wagistrasse 25, Schlieren 8952, Switzerland
    J Immunol 184:4615-9. 2010
    ..Interestingly, the presence of TLR7 ligand within virus-like particles largely restored defective GC reaction and Ab responses in global as well as in ..
  67. pmc Influenza virus activates inflammasomes via its intracellular M2 ion channel
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Immunol 11:404-10. 2010
    ..Our results show a mechanism by which influenza virus infection activates inflammasomes and identify the sensing of disturbances in intracellular ionic concentrations as a previously unknown pathogen-recognition pathway...
  68. pmc Respiratory virus-induced TLR7 activation controls IL-17-associated increased mucus via IL-23 regulation
    Nicholas W Lukacs
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 185:2231-9. 2010
    ..In the current study, the role of TLR7 that recognizes ssRNA was examined...
  69. pmc TLR8 deficiency leads to autoimmunity in mice
    Olivier Demaria
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    J Clin Invest 120:3651-62. 2010
    ..We found that Tlr8(-/-) DCs overexpressed TLR7, were hyperresponsive to various TLR7 ligands, and showed stronger and faster NF-κB activation upon stimulation ..
  70. pmc Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice
    Michael Waisberg
    Laboratories of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 108:1122-7. 2011
    ....
  71. pmc Innate immune sensing of retroviral infection via Toll-like receptor 7 occurs upon viral entry
    Melissa Kane
    Department of Microbiology, University of Chicago, 920 E 58th Street, Chicago, IL 60637, USA
    Immunity 35:135-45. 2011
    ..Thus, efficient adaptive immunity to retroviruses is induced in vivo by innate sensing of the early stages of retroviral infection...
  72. pmc TLR7 and TLR9 trigger distinct neuroinflammatory responses in the CNS
    Niranjan B Butchi
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, Hamilton, Montana 59840, USA
    Am J Pathol 179:783-94. 2011
    ..b>TLR7 and TLR9 are similar regarding localization and signal transduction mechanisms...
  73. pmc Poly-thymidine oligonucleotides mediate activation of murine glial cells primarily through TLR7, not TLR8
    Min Du
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, United States of America
    PLoS ONE 6:e22454. 2011
    ..Murine TLR8 does not appear to respond to human TLR7/8 agonists, due to a five amino acid deletion in the ectodomain...
  74. pmc Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice
    Victoria Jeisy-Scott
    Influenza Division, National Center for Immunization and Respiratory, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e25242. 2011
    ..and adaptive immune response against influenza A virus (IAV) infection; however, the role of Toll-like receptor 7 (TLR7) during the innate immune response to IAV infection and the cell types affected by the absence of TLR7 are not ..
  75. doi Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS
    Angela Dann
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Nat Neurosci 15:98-106. 2011
    ....
  76. doi An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
    Sabrina M Lehmann
    Department of Neurology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Nat Neurosci 15:827-35. 2012
    ..let-7 activates the RNA-sensing Toll-like receptor (TLR) 7 and induces neurodegeneration through neuronal TLR7. Cerebrospinal fluid (CSF) from individuals with Alzheimer’s disease contains increased amounts of let-7b, and ..
  77. doi Toll-like receptor 7 protects from atherosclerosis by constraining "inflammatory" macrophage activation
    Maria Salagianni
    Center for Immunology and Transplantation, Biomedical Research Foundation, Academy of Athens, Soranou Efesiou 4, Athens 11527, Greece
    Circulation 126:952-62. 2012
    ..However, evidence for most TLRs beyond TLR2 and TLR4 is lacking...
  78. doi TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification
    Marina Oldenburg
    Institute of Medical Microbiology, University of Duisburg Essen, Essen, Germany
    Science 337:1111-5. 2012
    ..Thus, our results reveal both a natural TLR13 ligand and specific mechanisms of antibiotic resistance as potent bacterial immune evasion strategy, avoiding recognition via TLR13...
  79. doi Cutting edge: TLR13 is a receptor for bacterial RNA
    Asa Hidmark
    Department of Infectious Diseases, Medical Microbiology and Hygiene, University of Heidelberg, 69120 Heidelberg, Germany
    J Immunol 189:2717-21. 2012
    ..analysis of murine DCs showed that bRNA induced gene regulation similar to that induced by stimulation of TLR7 with R848...
  80. pmc Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity
    Elizabeth R Walsh
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 109:16276-81. 2012
    Toll-like receptor 7 (Tlr7) has been linked to systemic lupus disease incidence in humans and mice, but how TLR7 potentiates autoimmunity is unclear...
  81. pmc The Yaa locus and IFN-α fine-tune germinal center B cell selection in murine systemic lupus erythematosus
    Ioana Moisini
    Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY 11030
    J Immunol 189:4305-12. 2012
    Male NZW/BXSB.Yaa (W/B) mice express two copies of TLR7 and develop pathogenic autoantibodies, whereas females with only one copy of TLR7 have attenuated disease...
  82. doi Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors
    Philipp Yu
    Institut fur Immunologie, Philipps Universitat Marburg, Marburg, Germany
    Immunity 37:867-79. 2012
    ..Here we report that nucleic acid-recognizing Toll-like receptors 3, 7, and 9 (TLR 3, TLR7, and TLR9) are essential for the control of ERVs...
  83. pmc Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice
    Xizhang Sun
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 190:2536-43. 2013
    b>TLR7 activation is implicated in the pathogenesis of systemic lupus erythematosus. Mice that overexpress TLR7 develop a lupus-like disease with autoantibodies and glomerulonephritis and early death...
  84. pmc Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells
    Natalia V Giltiay
    Department of Immunology and 2 Division of Rheumatology, School of Medicine, University of Washington, Seattle, WA 98195
    J Exp Med 210:2773-89. 2013
    ..It is still unclear, however, where and how TLR7-mediated interactions affect the development of autoreactive B cells...
  85. pmc Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation
    Shaun W Jackson
    Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195
    J Immunol 192:4525-32. 2014
    ..The endosomal TLRs TLR7 and TLR9 are critical for generation of Abs targeting RNA- or DNA-associated Ags, respectively...
  86. ncbi Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
    Veit Hornung
    Department of Internal Medicine, Division of Clinical Pharmacology, Ludwig Maximilians University of Munich, Ziemssenstr 1, 80336 Munchen, Germany
    Nat Med 11:263-70. 2005
    ..Immunostimulation by siRNA was absent in TLR7-deficient mice...
  87. ncbi The functional effects of physical interactions among Toll-like receptors 7, 8, and 9
    Jianyong Wang
    Department of Pharmacology, 3M Pharmaceutical Division, St Paul, Minnesota 55144, USA
    J Biol Chem 281:37427-34. 2006
    ..The other TLRs that are evolutionarily closely related and highly homologous are TLR7, TLR8, and TLR9...
  88. doi Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis
    Emina Savarese
    Department of Internal Medicine II, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Arthritis Rheum 58:1107-15. 2008
    ....
  89. doi Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells
    Nicholas A Forward
    Department of Microbiology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Leukoc Biol 87:117-25. 2010
    Although signaling through certain TLRs is known to modulate the function of T lymphocytes, the effect of TLR7 stimulation on CD4(+)CD25(+) T(reg) cell activity has not yet been elucidated...
  90. ncbi Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland
    Nat Med 11:138-45. 2005
    ..These data identify the 'inflammatory status' of the target organ as a separate and limiting factor determining the development of autoimmune disease...
  91. ncbi Expression of IL-27 p28 by Theiler's virus-infected macrophages depends on TLR3 and TLR7 activation of JNK-MAP-kinases
    Lara Hause
    Department of Oral Biology and the Nebraska Center for Virology, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    Antiviral Res 76:159-67. 2007
    ..demyelinating disease (DD) due to infection of macrophages, stimulation of macrophage Toll-like receptor (TLR)3 and TLR7 pathways, activation of Mitogen-activated protein kinases (MAPK)s, and production of macrophages cytokines...
  92. ncbi Intra-colonic administration of the TLR7 agonist R-848 induces an acute local and systemic inflammation in mice
    Agneta Karlsson
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, Sweden
    Biochem Biophys Res Commun 367:242-8. 2008
    ..such as resiquimod (R-848), are well known topically active immune modifiers that bind to toll-like receptor 7 (TLR7)...
  93. doi Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice
    Toshihiko Kobayashi
    Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Int Immunol 20:881-91. 2008
    ..Recent reports have indicated that TLR7 and TLR9 have an important role in activating autoreactive B cells...
  94. ncbi Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7
    Alessandra Vultaggio
    Center for Research, Transfer and High Education DENOthe, Department of Internal Medicine, University of Florence, Florence, Italy
    J Immunol 182:880-9. 2009
    ..In conclusion, critical substitutions in the adenine backbone creates a novel synthetic TLR7 ligand that shows the ability to ameliorate Th2-mediated airway inflammation by a complex mechanism, involving Th1 ..
  95. doi Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production
    Yumiko Tsukamoto
    Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Mol Immunol 46:1278-88. 2009
    ..The role of TLR7 and MyD88 in 8-SGuo-induced AID expression and mu to gamma1 CSR was documented, as 8-SGuo did not act on CD38-..
  96. doi Involvement of interleukin-1 receptor-associated kinase (IRAK)-M in toll-like receptor (TLR) 7-mediated tolerance in RAW 264.7 macrophage-like cells
    Ferdaus Hassan
    Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Yazako, Nagakute, Japan
    Cell Immunol 256:99-103. 2009
    ..receptor (TLR) 7 ligand pretreatment on the production of tumor necrosis factor (TNF)-alpha in response to TLR7 or TLR2 ligand was examined in order to establish a new TLR-mediated tolerance. RAW 264...
  97. doi Allergic sensitization is enhanced in early life through toll-like receptor 7 activation
    S Phipps
    Centre for Asthma and Respiratory Diseases CARD and Hunter Medical Research Institute HMRI, School of Biomedical Sciences, University of Newcastle, Newcastle, NSW, Australia
    Clin Exp Allergy 39:1920-8. 2009
    ..Prospective cohort studies suggest that children hospitalized in early life with severe infections are significantly more likely to develop recurrent wheezing and asthma...
  98. doi Release of IL-12 by dendritic cells activated by TLR ligation is dependent on MyD88 signaling, whereas TRIF signaling is indispensable for TLR synergy
    Mathias Krummen
    Department of Dermatology, University of Mainz, Mainz, Germany
    J Leukoc Biol 88:189-99. 2010
    ..Finally, we show that synergy is partially dependent on IFNAR signaling but does not require the release of IFNs to the enviroment, suggesting an autocrine action of type I IFNs...
  99. pmc The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling
    Hua Tang
    Emory Vaccine Center, Atlanta, Georgia, USA
    Nat Immunol 11:608-17. 2010
    ..Thus, the T(H)2 response to cysteine proteases requires DC-basophil cooperation via ROS-mediated signaling...
  100. pmc MyD88-dependent signaling contributes to host defense against ehrlichial infection
    Young Sang Koh
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS ONE 5:e11758. 2010
    ....
  101. pmc Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons
    Josh Gregorio
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 207:2921-30. 2010
    ..pDCs were found to rapidly infiltrate both murine and human skin wounds and to transiently produce type I IFNs via TLR7- and TLR9-dependent recognition of nucleic acids...

Research Grants5

  1. Macrophage defense againt M. tuberculosis
    Jennifer Wang; Fiscal Year: 2008
    ..abstract_text> ..
  2. Genes that Mediate Tolerance to the Placental Allograft
    Bruce Beutler; Fiscal Year: 2006
    ..Fourth, circumvention of the toleragenic mechanism might be used to prevent normal gestation, leading to termination of pregnancy within a few days following implantation of the blastocyst. ..
  3. Forward Genetic Analysis of the Innate Immune Contribution to MCMV Resistance
    Bruce Beutler; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  4. Mutagenic analysis of LPS responses
    Bruce Beutler; Fiscal Year: 2006
    ..In the case of mutations that abolish LPS tolerance, we will attempt to determine the net impact on host resistance to infection. ..
  5. TLR4 as an LPS sendor and susceptibility locus
    Bruce Beutler; Fiscal Year: 2007
    ..The new mutations that are found--and those that have already been found in preliminary efforts--will be isolated by positional cloning. ..