Tpbpa

Summary

Gene Symbol: Tpbpa
Description: trophoblast specific protein alpha
Alias: AV033951, Tb-1, Tb1, Tpbp, b2b1247Clo, trophoblast-specific protein alpha, Mutant line 1247, clone 4311
Species: mouse

Top Publications

  1. ncbi Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development
    R Szabo
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 26:1546-56. 2007
  2. ncbi Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes
    T Teesalu
    Dipartimento di Ricerca Biologica e Tecnologica DIBIT, Istituto Scientifico S Raffaele, Milano, Italy
    Mech Dev 56:103-16. 1996
  3. ncbi Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice
    Verena Muthig
    Institute of Experimental and Clinical Pharmacology, University of Freiburg, Albertstrasse 25, 79104 Freiburg, Germany
    Circ Res 101:682-91. 2007
  4. ncbi Isolation and characterization of a novel trophoblast-specific cDNA in the mouse
    K R Lescisin
    Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada
    Genes Dev 2:1639-46. 1988
  5. ncbi Essential role of Mash-2 in extraembryonic development
    F Guillemot
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 371:333-6. 1994
  6. ncbi Targeted disruption of the Wnt2 gene results in placentation defects
    S J Monkley
    Centre for Molecular and Cellular Biology, University of Queensland, Australia
    Development 122:3343-53. 1996
  7. ncbi The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis
    P Riley
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nat Genet 18:271-5. 1998
  8. pmc Requirement of the mouse I-mfa gene for placental development and skeletal patterning
    N Kraut
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, A3 025, PO Box 19024, Seattle, WA 98109 1024, USA
    EMBO J 17:6276-88. 1998
  9. ncbi Esx1 is an X-chromosome-imprinted regulator of placental development and fetal growth
    Y Li
    Department of Molecular Genetics, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 20:309-11. 1998
  10. pmc Placental failure in mice lacking the homeobox gene Dlx3
    M I Morasso
    Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:162-7. 1999

Scientific Experts

Detail Information

Publications104 found, 100 shown here

  1. ncbi Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development
    R Szabo
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 26:1546-56. 2007
    ..Furthermore, matriptase/HAI-1 double-deficient mice were phenotypically indistinguishable from matriptase single-deficient littermates...
  2. ncbi Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes
    T Teesalu
    Dipartimento di Ricerca Biologica e Tecnologica DIBIT, Istituto Scientifico S Raffaele, Milano, Italy
    Mech Dev 56:103-16. 1996
    ..5 and 8.5 days. Our studies outline the expression of a set of functionally related genes that is well coordinated between fetal and maternal tissues. This coordination may model other physiological and pathological invasive processes...
  3. ncbi Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice
    Verena Muthig
    Institute of Experimental and Clinical Pharmacology, University of Freiburg, Albertstrasse 25, 79104 Freiburg, Germany
    Circ Res 101:682-91. 2007
    ....
  4. ncbi Isolation and characterization of a novel trophoblast-specific cDNA in the mouse
    K R Lescisin
    Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada
    Genes Dev 2:1639-46. 1988
    ..The role of the gene is not currently known, but the presence of a signal peptide suggests that it may be a secreted protein...
  5. ncbi Essential role of Mash-2 in extraembryonic development
    F Guillemot
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 371:333-6. 1994
    ..Mash-2 is the first transcription factor shown to play a critical part in the development of the mammalian trophoblast lineage...
  6. ncbi Targeted disruption of the Wnt2 gene results in placentation defects
    S J Monkley
    Centre for Molecular and Cellular Biology, University of Queensland, Australia
    Development 122:3343-53. 1996
    ..These results suggest that Wnt2 is required for the proper vascularisation of the mouse placenta and the placental defects in Wnt2-deficient mice result in a reduction in birthweight and perinatal lethality...
  7. ncbi The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis
    P Riley
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nat Genet 18:271-5. 1998
    ..Their heart tubes showed abnormal looping and ventricular myocardial differentiation. Therefore, Hand1 is essential for differentiation of both trophoblast and cardiomyocytes, which are embryologically distinct cell lineages...
  8. pmc Requirement of the mouse I-mfa gene for placental development and skeletal patterning
    N Kraut
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, A3 025, PO Box 19024, Seattle, WA 98109 1024, USA
    EMBO J 17:6276-88. 1998
    ..Our results indicate that I-mfa plays an important role in trophoblast and chondrogenic differentiation by negatively regulating a subset of lineage-restricted bHLH proteins...
  9. ncbi Esx1 is an X-chromosome-imprinted regulator of placental development and fetal growth
    Y Li
    Department of Molecular Genetics, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 20:309-11. 1998
    ..These results identify Esx1 as the first essential X-chromosome-imprinted regulator of placental development that influences fetal growth, and may aid our understanding human placental insufficiency syndromes...
  10. pmc Placental failure in mice lacking the homeobox gene Dlx3
    M I Morasso
    Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:162-7. 1999
    ....
  11. pmc JunB is essential for mammalian placentation
    M Schorpp-Kistner
    Deutsches Krebsforschungszentrum Heidelberg, Abteilung für Signaltransduktion und Wachstumskontrolle, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    EMBO J 18:934-48. 1999
    ..Therefore, JunB appears to be involved in multiple signaling pathways regulating genes involved in the establishment of a proper feto-maternal circulatory system...
  12. ncbi Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
    S Giroux
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, Pavillon L Hotel Dieu de Quebec, 9, a rue McMahon, Quebec, Canada, G1R 2J6
    Curr Biol 9:369-72. 1999
    ..They also suggest that mek1 function is required for normal response to angiogenic signals that might promote vascularization of the labyrinthine region of the placenta...
  13. ncbi A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting
    D Frank
    Institute for Cancer Genetics and Department of Pathology, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, New York 10032, USA
    Mamm Genome 10:1150-9. 1999
    ..The data also define a new subfamily of PH domain genes...
  14. pmc Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis
    J S Mudgett
    Merck Research Laboratories, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 97:10454-9. 2000
    ..Thus, our results indicate a requirement for p38alpha MAPK in diploid trophoblast development and placental vascularization and suggest a more general role for p38 MAPK signaling in embryonic angiogenesis...
  15. ncbi Placental vascularisation requires the AP-1 component fra1
    M Schreiber
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Development 127:4937-48. 2000
    ..In contrast, the spongiotrophoblast layer was unaffected and expressed the marker genes 4311 (Tpbp) and Flt1...
  16. ncbi Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta
    S Lee Adamson
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Obstetrics and Gynecology, University of Toronto, Ontario, Canada
    Dev Biol 250:358-73. 2002
    ..5. These cells did not express Plf, but rather expressed the spongiotrophoblast-specific gene Tpbp. Dilation of the spiral arteries was obvious between E10.5 and E14...
  17. pmc Carcinoembryonic antigen-related cell adhesion molecule 10 expressed specifically early in pregnancy in the decidua is dispensable for normal murine development
    Daniela Finkenzeller
    Institute of Molecular Medicine and Cell Research, University of Freiburg, Germany
    Mol Cell Biol 23:272-9. 2003
    ..Taken together, both Ceacam10 and Ceacam9, alone or in combination, are not essential for either murine placental and embryonic development or for adult life...
  18. pmc Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
    Hsiuchen Chen
    Division of Biology, Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA
    J Cell Biol 160:189-200. 2003
    ..Therefore, mitochondrial fusion is essential for embryonic development, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population...
  19. pmc Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta
    Hiroyuki Tanaka
    Second Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Mol Cell Biol 25:5687-98. 2005
    ..Our results indicate that mouse HAI-1 is essential for branching morphogenesis in the chorioallantoic placenta and lack of HAI-1 function may result in placental failure...
  20. ncbi Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality
    Ryuichi Ono
    Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Nat Genet 38:101-6. 2006
    ..This indicates that Peg10 is critical for mouse parthenogenetic development and provides the first direct evidence of an essential role of an evolutionarily conserved retrotransposon-derived gene in mammalian development...
  21. ncbi Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta
    S L Withington
    Developmental Biology Program, Victor Chang Cardiac Research Institute, Sydney, Australia
    Dev Biol 294:67-82. 2006
    ..We conclude that Cited2 is required for normal placental development and vascularisation, and hence for embryo viability...
  22. pmc HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification
    Carley A E Shaut
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Genet 4:e1000073. 2008
    ....
  23. pmc The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development
    Vicky Katsanou
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, 16672 Vari, Greece
    Mol Cell Biol 29:2762-76. 2009
    ..Collectively, our data demonstrate the dominant role of HuR in organizing gene expression programs guiding placental labyrinth morphogenesis, skeletal specification patterns, and splenic ontogeny...
  24. pmc The imprinted Phlda2 gene regulates extraembryonic energy stores
    S J Tunster
    Genetics Division, Cardiff School of Biosciences, Cardiff University, Cardiff, Wales CF10 3AX, United Kingdom
    Mol Cell Biol 30:295-306. 2010
    ..In addition, glycogen cells do not migrate into the maternal decidua in a timely fashion, but instead, Tpbpa-positive cells progressively mislocalize into the labyrinth...
  25. pmc A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast
    Anne Dupressoir
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8122, and Unité de Génomique Fonctionnelle, Institut Gustave Roussy, 94805 Villejuif, France
    Proc Natl Acad Sci U S A 108:E1164-73. 2011
    ..Although some are absolutely required for completion of pregnancy, others are still amenable to "epigenetic" compensations, thus illustrating the complexity of the molecular machinery that developed during placental evolution...
  26. pmc The Notch target genes Hey1 and Hey2 are required for embryonic vascular development
    Andreas Fischer
    Theodor Boveri Institut für Biowissenschaften Biozentrum, Physiologische Chemie I, Universitat Wurzburg, 97074 Wurzburg, Germany
    Genes Dev 18:901-11. 2004
    ..This indicates that Hey1/Hey2 are essential transducers of Notch signals in cardiovascular development that may mediate arterial cell fate decision...
  27. ncbi The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice
    Johan van Nes
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht
    Development 133:419-28. 2006
    ..Cdx genes thus operate in a redundant way during placentogenesis, as they do during embryonic axial elongation and patterning, and independently from the previously reported early Cdx2-specific role in the trophectoderm at implantation...
  28. ncbi Murine Gcm1 gene is expressed in a subset of placental trophoblast cells
    E Basyuk
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Dyn 214:303-11. 1999
    ..5 within a subset of labyrinthine trophoblast cells. Comparison with other transcription factors revealed that Gcm1 expression defines a unique subset of trophoblast cells...
  29. ncbi An X-chromosome linked locus contributes to abnormal placental development in mouse interspecific hybrid
    U Zechner
    Abteilung Medizinische Genetik der Universität Ulm, Germany
    Nat Genet 12:398-403. 1996
    ..Hypotrophy of the placenta frequently leads to growth impairment or death of the fetus. One of the major genetic determinants of placental growth maps to the proximal part of the mouse X chromosome...
  30. ncbi Expression and function of the urokinase type plasminogen activator during mouse hemochorial placental development
    T Teesalu
    Dipartimento di Ricerca Biologica e Tecnologica DIBIT, Istituto Scientifico S Raffaele, and Università di Milano, Italy
    Dev Dyn 213:27-38. 1998
    ..The function of uPA in trophoblast invasion appears not to be indispensable, and its absence can be overcome by redundant or compensatory mechanisms...
  31. ncbi Mice lacking HSP90beta fail to develop a placental labyrinth
    A K Voss
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Goettingen, Germany
    Development 127:1-11. 2000
    ..The allantois mesoderm is thought to induce trophoblast differentiation. Our results show that Hsp90beta is a necessary component of this induction process...
  32. ncbi Transgenic major histocompatibility complex class I antigen expressed in mouse trophoblast affects maternal immature B cells
    D Ait-Azzouzene
    Laboratory of Immune Regulations and Development, J Monod Institute, UMR 7592, CNRS and Universities Paris 6 and 7, 75251 Paris Cedex 05, France
    Biol Reprod 65:337-44. 2001
    ..5, compared to 22% in the (3.83 Tg female x Fvb) control group. This deletion might contribute to the process of maternal tolerance of the conceptus...
  33. pmc Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development
    Ryosuke Tsunematsu
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mol Cell Biol 26:6157-69. 2006
    ..These results suggest that the Cul7-based SCF-like E3 complex has both Fbxw8-dependent and Fbxw8-independent functions...
  34. ncbi Placenta defects and embryonic lethality resulting from disruption of mouse hydroxysteroid (17-beta) dehydrogenase 2 gene
    Pia Rantakari
    Department of Physiology, Institute of Biomedicine, University of Turku, FIN 20520 Turku, Finland
    Mol Endocrinol 22:665-75. 2008
    ..Our results provide evidence for a role for HSD17B2 enzyme in the cellular organization of the mouse placenta...
  35. doi Cathepsin proteases have distinct roles in trophoblast function and vascular remodelling
    Mark Screen
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    Development 135:3311-20. 2008
    ..Our findings provide evidence for the highly specialized functions of closely related cysteine cathepsin proteases in extra-embryonic development, and reinforce their importance for a successful outcome of pregnancy...
  36. pmc Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome
    Rosemary Oh-McGinnis
    Department of Medical Genetics, Molecular Epigenetics Group, Life Sciences Institute, University of British Columbia, Vancouver, Canada
    BMC Dev Biol 10:50. 2010
    ..When the IC2KO mutation is paternally inherited, epigenetic silencing is lost in the region and the DelTel7 lethality is rescued in compound heterozygotes, leading to viable DelTel7/IC2KO mice...
  37. pmc NOA1 is an essential GTPase required for mitochondrial protein synthesis
    Mateusz Kolanczyk
    Development and Disease Group, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
    Mol Biol Cell 22:1-11. 2011
    ..Thus, NOA1 is required for such basal mitochondrial functions as adenosine triphosphate (ATP) synthesis and apoptosis...
  38. doi Ablation of Tpbpa-positive trophoblast precursors leads to defects in maternal spiral artery remodeling in the mouse placenta
    Dong Hu
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
    Dev Biol 358:231-9. 2011
    ..The Tpbpa gene is expressed in ectoplacental cone cells starting between embryonic days (E) 7.5 and 8...
  39. doi Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta
    D J Pennisi
    Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Australia
    Placenta 33:175-82. 2012
    ..Our findings show that Crim1 is required for placental development, and is necessary for the proper differentiation of sinusoidal-trophoblast giant cells and glycogen trophoblast cells...
  40. pmc The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r
    Andrew Keniry
    Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK
    Nat Cell Biol 14:659-65. 2012
    ..The controlled release of miR-675 from H19 may also allow rapid inhibition of cell proliferation in response to cellular stress or oncogenic signals...
  41. doi Ly6e expression is restricted to syncytiotrophoblast cells of the mouse placenta
    M Hughes
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada
    Placenta 34:831-5. 2013
    ..Our findings suggest that LY6E is expressed in differentiated syncytiotrophoblast and may also be useful as an early marker, expressed in progenitors of this cell-type...
  42. pmc Peri-implantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth
    Monica A Mainigi
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania
    Biol Reprod 90:26. 2014
    ....
  43. pmc Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis
    Xingrong Du
    State Key Laboratory of Genetic Engineering and National Center for International Research of Development and Disease, Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 9:e90701. 2014
    ..Thus, our studies have defined novel roles of Mst1/2 in mouse placental development. ..
  44. pmc Connexin31.1 (Gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development
    Mark Kibschull
    1 Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada
    Stem Cells Dev 23:2649-60. 2014
    ..terminal differentiation of trophoblast cells during placentation resulting in a delayed induction of marker genes Tpbpa, Prl3b1/Pl-2, and Ctsq in Cx31.1-deficient placentas. Derivation and analysis of Cx31...
  45. pmc Slc20a2 deficiency results in fetal growth restriction and placental calcification associated with thickened basement membranes and novel CD13 and lamininα1 expressing cells
    Mary C Wallingford
    University of Washington, Department of Bioengineering, 3720 15th Ave NE, Seattle, WA 98195, USA Electronic address
    Reprod Biol 16:13-26. 2016
    ....
  46. doi The developmental expression of the CDK inhibitor p57(kip2) (Cdkn1c) in the early mouse placenta
    Ann Catherine Eugenia Saunders
    Department of Pediatrics, Brown University, Women and Infants Hospital of Rhode Island, Providence, Rhode Island
    Mol Reprod Dev 83:405-12. 2016
    ..5. The early and intense expression in trophoblast giant cells is consistent with a role for p57(kip2) in the invasive phenotype of these cells. Mol. Reprod. Dev. 83: 405-412, 2016. © 2016 Wiley Periodicals, Inc. ..
  47. doi Relationships between homeoprotein EGAM1C and the expression of the placental prolactin gene family in mouse placentae and trophoblast stem cells
    Koichi Saito
    Departments of Biotechnology Biological Production, Faculty of Bioresource Sciences, Akita Prefectural University, Akita 010 0195, Japan
    Reproduction 141:259-68. 2011
    ..These results indicated that EGAM1C may play a role in the expression of members of the placental PRL gene family, such as Prl3b1 and Prl5a1...
  48. pmc NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy
    Craig B Park
    Division of Experimental Medicine, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    Biol Reprod 86:194. 2012
    ....
  49. pmc Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation
    Joshua W Mugford
    The University of North Carolina at Chapel Hill, Department of Genetics, Carolina Center for Genome Sciences, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7264, USA
    Development 139:2130-8. 2012
    ..Conversely, unlike the epiblast, in which XCI is not required for progenitor cell maintenance, we demonstrate that dosage compensation is indispensable for the maintenance of trophoblast progenitors...
  50. pmc Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network
    Tali Shalom-Barak
    Magee Womens Research Institute, Department of OBGYN and Reproductive Sciences, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    Dev Biol 372:143-55. 2012
    ..These findings offer insights not only into the placental functions of PPARγ, but also into unique, previously unsuspected biosynthetic functions of trophoblasts...
  51. pmc Conditional deletions refine the embryonic requirement for Dlk1
    Oliver K Appelbe
    Department of Biological Sciences, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA
    Mech Dev 130:143-59. 2013
    ..Dlk1(flox) mice will continue to provide an important tool for further research into the function of Dlk1...
  52. pmc The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice
    Judith Reichmann
    MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Universityof Edinburgh, Crewe Road, Edinburgh, UK
    Hum Mol Genet 22:1791-806. 2013
    ....
  53. ncbi A novel regulatory region is required for trophoblast-specific transcription in transgenic mice
    T Calzonetti
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dev Biol 171:615-26. 1995
    ..Delineation of a diploid trophoblast-specific regulatory region will facilitate the identification of factors that may regulate the development of this lineage...
  54. pmc Paternal transmission of X-linked placental dysplasia in mouse interspecific hybrids
    U Zechner
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Genetics 146:1399-405. 1997
    ..This finding supports the view that it is expression of the M. macedonicus Ihpd locus in the spongiotrophoblast that leads to hyperplasia due to an abnormal interaction with M. musculus autosomal loci...
  55. ncbi Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway
    H Nakayama
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dev Genet 21:21-30. 1997
    ..These data suggest that Notch signaling through activation of HES transcriptional repressors may play a role in murine placental development...
  56. ncbi Defects of the chorioallantoic placenta in mouse RXRalpha null fetuses
    V Sapin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, C U de Strasbourg, Illkirch Cedex, 67404, France
    Dev Biol 191:29-41. 1997
    ..Thus, placental defects could represent an extraembryonic cause of lethality for RXRalpha null mutant fetuses, in addition to the previously described embryonic cardiac defects...
  57. ncbi Disruption of primary imprinting during oocyte growth leads to the modified expression of imprinted genes during embryogenesis
    Y Obata
    NODAI Research Institute, Tokyo University of Agriculture, Tokyo, Japan
    Development 125:1553-60. 1998
    ..Thus, our results show that primary imprinting during oocyte growth exhibits a crucial effect on both the expression and repression of maternal alleles during embryogenesis...
  58. ncbi Normal reproductive and macrophage function in Pem homeobox gene-deficient mice
    J L Pitman
    Cancer Center, Graduate Program in Biomedical Sciences, Department of Reproductive Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0684, USA
    Dev Biol 202:196-214. 1998
    ..Together, these data show that Pem is dispensable for embryonic and postnatal development, gonadal function, and Kupffer cell activation, perhaps due to compensatory expression of a similar homeobox gene...
  59. ncbi Expression pattern of the epithelial v-like antigen (Eva) transcript suggests a possible role in placental morphogenesis
    T Teesalu
    Department of Biological and Technological Research DIBIT, San Raffaele HSR Scientific Institute, Milan, Italy
    Dev Genet 23:317-23. 1998
    ..The expression pattern of Eva transcripts suggests that during mouse placenta formation, its protein product may play a role in the processes of trophoblast invasion, decidual response, and trophoblast-decidual interaction...
  60. ncbi Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development
    P J Hunter
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Departments of Obstetrics and Gynaecology, and Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1X5, Canada
    Development 126:1247-58. 1999
    ..The specificity of the developmental defect in Mrj mutants suggests that each of these genes may have unique tissue and cellular activities...
  61. ncbi Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation
    M Tanaka
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Mech Dev 87:129-42. 1999
    ..Our results suggest the possibility that a mechanism other than DNA methylation, such as allele-specific chromatin conformation, may be involved in maintenance of parental origin-specific expression of Mash2...
  62. ncbi Expression of the imprinted genes MEST/Mest in human and murine placenta suggests a role in angiogenesis
    W Mayer
    Max Planck Institut fur Molekulare Genetik, Berlin Dahlem, Germany
    Dev Dyn 217:1-10. 2000
    ..dev dyn 2000;217:1-10...
  63. ncbi Pregnancy specific glycoprotein 18 induces IL-10 expression in murine macrophages
    J Wessells
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda 20814, USA
    Eur J Immunol 30:1830-40. 2000
    ..Taken together, these results suggest that PSG18 selectively up-regulates IL-10 production by macrophages, providing a possible mechanism by which this protein helps promote successful pregnancy...
  64. ncbi Genetic analysis of the organic cation transporter genes Orct2/Slc22a2 and Orct3/Slc22a3 reduces the critical region for the t haplotype mutant t(w73) to 200 kb
    R Zwart
    Netherlands Cancer Institute, Dept of Molecular Genetics H5, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Mamm Genome 12:734-40. 2001
    ..The results eliminate both Orct2 and Orct3 as candidates and further reduce the critical region containing the t(w73) mutant from 500 kb to 200 kb...
  65. ncbi Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality
    Shao Qing Kuang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:45356-60. 2002
    ..These results also indicate that the biological function of AIB3 is not redundant with other classes of nuclear receptor coactivators such as PBP and members of the steroid receptor coactivator family...
  66. pmc Cited1 is required in trophoblasts for placental development and for embryo growth and survival
    Tristan A Rodriguez
    Mammalian Development Division, National Institute for Medical Research, London, United Kingdom
    Mol Cell Biol 24:228-44. 2004
    ..We conclude that Cited1 is required in trophoblasts for normal placental development and subsequently for embryo viability...
  67. pmc Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice
    Markus Moser
    Max Planck Institute for Biochemistry, D 82152 Martinsried, Germany
    Mol Cell Biol 24:1667-79. 2004
    ..Additionally, impairment of vasculogenesis in the yolk sacs and embryos of null mutant conceptuses suggested that NTE is also required for normal blood vessel development...
  68. ncbi Foxd3 is required in the trophoblast progenitor cell lineage of the mouse embryo
    Dennie M Tompers
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104 6058, USA
    Dev Biol 285:126-37. 2005
    ..Moreover, this provides support for the hypothesis that there are conserved molecular mechanisms for maintaining the self-renewing properties of diverse progenitor cell types...
  69. ncbi Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1
    Umashankar Singh
    Department of Development and Genetics, Evolutionary Biology Center, Uppsala University, Sweden
    Dev Dyn 234:1034-45. 2005
    ..This strongly suggested that altered expression of Car2 and Ncam1 is a downstream event in placental hyperplasia...
  70. pmc Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation
    Karen D Cowden Dahl
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium
    Mol Cell Biol 25:10479-91. 2005
    ..This novel genetic approach provides new insights into the role of O2 tension in the development of life-threatening pregnancy-related diseases such as preeclampsia...
  71. pmc Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta
    Karim Nadra
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 26:3266-81. 2006
    ..Altogether, this important role of PPARbeta/delta in placenta development and giant cell differentiation should be considered when contemplating the potency of PPARbeta/delta agonist as therapeutic agents of broad application...
  72. pmc Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency
    Fabrice G Petit
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA corrected
    Proc Natl Acad Sci U S A 104:6293-8. 2007
    ..The endometrial COUP-TFII might modulate the signaling between the uterus and the extraembryonic tissue for the proper formation of the placenta...
  73. pmc Transcriptional repressor erf determines extraembryonic ectoderm differentiation
    Chara Papadaki
    Medical School, University of Crete, Voutes, Heraklion, Crete 710 03, Greece
    Mol Cell Biol 27:5201-13. 2007
    ..Our data suggest that attenuation of FGF/Erk signaling and consecutive Erf nuclear localization and function is required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment...
  74. ncbi HOP/NECC1, a novel regulator of mouse trophoblast differentiation
    Kazuo Asanoma
    Division of Molecular and Cell Therapeutics, Kyushu University, Japan
    J Biol Chem 282:24065-74. 2007
    ....
  75. pmc Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta
    Geng Tian
    Department of Animal Genetics and Development, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Dev Dyn 237:1517-25. 2008
    ..However, absence of both LIM-3 genes did not interfere with placental transport nor consistently with expression of target genes such as Gnrhr. Thus, LHX3 and LHX4 appear to be dispensable for placental development and function...
  76. doi Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia
    Keizo Kanasaki
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 453:1117-21. 2008
    ....
  77. pmc Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5
    Ray Kit Ng
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, UK
    Nat Cell Biol 10:1280-90. 2008
    ..This epigenetic restriction of cell lineage fate provides a molecular mechanism for Waddington's concept of canalization of developmental pathways...
  78. pmc Ott1 (Rbm15) is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleen
    Glen D Raffel
    Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 29:333-41. 2009
    ..Thus, Ott1-dependent pathways, in addition to being implicated in leukemogenesis, may also be important for the pathogenesis of placental insufficiency and cardiac malformations...
  79. pmc SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages
    Shang Yi Chiu
    Department of Biomedical Genetics, Center for Oral Biology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    PLoS Biol 6:e310. 2008
    ..Our data reveal a key genetic pathway, SENP2-Mdm2-p53, underlying trophoblast lineage development, suggesting its pivotal role in cell cycle progression of mitosis and endoreduplication...
  80. pmc LAT-1 expression in pre- and post-implantation embryos and placenta
    M K Chrostowski
    Division of Biology and Medicine, Graduate Program in Pathobiology, Brown University, Providence, Rhode Island, Brown University, 101 Dudley St, Providence, RI 02905, USA
    Placenta 30:270-6. 2009
    ..Our objectives were to analyze qualitatively and quantitatively LAT-1 expression in pre-implantation stages of mouse embryo development and to identify cell types expressing LAT-1 in post-implantation stages...
  81. pmc E2F4 cooperates with pRB in the development of extra-embryonic tissues
    Eunice Y Lee
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Biol 332:104-15. 2009
    ..Taken together, our data show that pRB and E2F4 cooperate in placental development, but play largely non-overlapping roles in the development of many embryonic tissues...
  82. doi Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate
    David R C Natale
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, The University of Calgary, Calgary, AB, Canada T2N 4N1
    Dev Biol 335:120-31. 2009
    ..These results suggest that Activin rather than TGF-beta (or Nodal) acts directly on TS cells influencing both TS cell maintenance and cell fate, depending on whether the cells are also exposed to FGF4...
  83. pmc Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
    Takao Iwawaki
    Iwawaki Initiative Research Unit, Advanced Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama, Japan
    Proc Natl Acad Sci U S A 106:16657-62. 2009
    ..These findings reveal that IRE1alpha plays an essential function in extraembryonic tissues and highlight the relationship of physiological ER stress and angiogenesis in the placenta during pregnancy in mammals...
  84. doi Maternally-inherited Grb10 reduces placental size and efficiency
    Marika Charalambous
    Department of Biology and Biochemistry, University of Bath, Building 4 South, Bath BA27AY, UK
    Dev Biol 337:1-8. 2010
    ..This grandparental effect suggests Grb10 can influence reproductive strategy through the allocation of maternal resources such that offspring number is offset against size...
  85. doi A Cdh1HA knock-in allele rescues the Cdh1-/- phenotype but shows essential Cdh1 function during placentation
    Marc P Stemmler
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Dyn 239:2330-44. 2010
    ..Placentas without Cdh1 expression are impaired and incapable of establishing a proper connection between the embryonic and the maternal blood vessels for efficient nutrient and oxygen transport...
  86. pmc Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction
    Rosemary Oh-McGinnis
    Department of Medical Genetics, Molecular Epigenetics Group, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada
    Dev Biol 351:277-86. 2011
    ....
  87. doi Translocon-associated protein subunit Trap-γ/Ssr3 is required for vascular network formation in the mouse placenta
    Yasuka L Yamaguchi
    Department of Kidney Development, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University, Kumamoto, Japan
    Dev Dyn 240:394-403. 2011
    ..Thus, Trap-γ appears to be required for vascular network formation in murine placental development...
  88. pmc Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues
    Cornelia Kröger
    Division of Cell Biochemistry, Institute of Biochemistry and Molecular Biology, University of Bonn, Bonn, Germany
    Am J Pathol 178:1578-90. 2011
    ..Our findings suggest that keratin mutations might mediate conditions leading to early pregnancy loss due to hyperoxia in the decidua...
  89. pmc Altered gene expression and spongiotrophoblast differentiation in placenta from a mouse model of diabetes in pregnancy
    J M Salbaum
    Laboratory of Regulation of Gene Expression, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Diabetologia 54:1909-20. 2011
    ..g. metabolic syndrome and hypertension. We hypothesised that adverse outcomes from diabetic pregnancies may be linked to compromised placental function, and sought to identify cellular and molecular abnormalities in diabetic placenta...
  90. pmc Retinoid X receptors are essential for early mouse development and placentogenesis
    O Wendling
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Centre National de la Recherche Scientifique, Pasteur Collège de France
    Proc Natl Acad Sci U S A 96:547-51. 1999
    ..Interestingly, as a RXR ligand appears dispensable, placentogenesis must be controlled by a yet unknown hormonal ligand(s) activating the heterodimerization partner(s) of RXRs...
  91. ncbi Expression of matrix metalloproteinases during murine chorioallantoic placenta maturation
    T Teesalu
    Dipartimento di Ricerca Biologica e Tecnologica DIBIT, Istituto Scientifico S Raffaele, Milano, Italia
    Dev Dyn 214:248-58. 1999
    ..Our findings document the participation of MMPs and their inhibitors in the process of late murine placenta maturation, and warrant the characterization of other members of the MMP family, like membrane type-MMPs, in this process...
  92. ncbi Nodal regulates trophoblast differentiation and placental development
    G T Ma
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois, USA 60208
    Dev Biol 236:124-35. 2001
    ....
  93. ncbi Wnt7b regulates placental development in mice
    B A Parr
    MCD Biology, University of Colorado, 347 UCB, Boulder, Colorado 80309 0347, USA
    Dev Biol 237:324-32. 2001
    ..Wnt7b also is required for normal organization of cells in the chorionic plate. Thus, Wnt7b signaling is central to the early stages of placental development in mammals...
  94. ncbi Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13
    Jan Deussing
    Institut für Molekulare Medizin und Zellforschung, Albert Ludwigs Universitat Freiburg, Hugstetter Strasse 55, Freiburg, 79106, FRG
    Genomics 79:225-40. 2002
    ..The specific expression pattern and high expression level suggest an essential role of cathepsin J-like peptidases and related genes in formation and development of the murine placenta...
  95. ncbi The mouse PcG gene eed is required for Hox gene repression and extraembryonic development
    Jianbo Wang
    Department of Genetics, CB 7264, The University of North Carolina, Chapel Hill 27599 7264, USA
    Mamm Genome 13:493-503. 2002
    ..However, genetic crosses with a Mash2 null allele suggested that Eed was not required to maintain Mash2 imprinting, but could be required in a lineage specific fashion to suppress Mash2 expression...
  96. ncbi Expression of a novel homeobox gene Ehox in trophoblast stem cells and pharyngeal pouch endoderm
    Melany Jackson
    John Hughes Bennett Laboratory, University of Edinburgh, Scotland, United Kingdom
    Dev Dyn 228:740-4. 2003
    ....
  97. ncbi Fetal loss in homozygous mutant Norrie disease mice: a new role of Norrin in reproduction
    Ulrich F O Luhmann
    Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University of Zurich, Schwerzenbach, Switzerland
    Genesis 42:253-62. 2005
    ..Taken together, these data provide strong evidence for Norrin playing an important role in female reproductive tissues...
  98. doi Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation
    Valerie Nadeau
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Quebec, QC, G1R 2J6, Canada
    Development 136:1363-74. 2009
    ..Thus, even though Map2k1 plays a predominant role, these results enlighten the function of Map2k2 in placenta development...
  99. pmc Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene
    Anne Dupressoir
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de Recherche Scientifique, Institut Gustave Roussy, 94805 Villejuif, and Université Paris Sud, 91405 Orsay, France
    Proc Natl Acad Sci U S A 106:12127-32. 2009
    ....
  100. ncbi Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta
    J Luo
    Molecular Oncology Group, Royal Victoria Hospital, Montreal, Quebec, Canada
    Nature 388:778-82. 1997
    ..Our results indicate that ERR-beta has an important role in early placentation, and suggest that an inductive signal originating from or modified by the chorion is required for normal trophoblast proliferation and differentiation...