Genomes and Genes
Gene Symbol: Ttr
Alias: AA408768, AI787086, D17860, prealbumin, transthyretin
Publications113 found, 100 shown here
- Identification of Evi-3, a novel common site of retroviral integration in mouse AKXD B-cell lymphomasM J Justice
Division of Biology, Kansas State University, Manhattan 66506
J Virol 68:1293-300. 1994..Transcripts from Evi-3 are expressed in a developmentally regulated manner in B cells. Taken together, these data suggest that Evi-3 represents a novel proto-oncogene involved in mouse B-cell lymphomas...
- The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient miceE A Grove
Department of Pharmacological and Physiological Sciences, University of Chicago, Chicago, IL, USA
Development 125:2315-25. 1998..In addition, although the cortical hem does not show features of differentiated CPe, such as expression of transthyretin mRNA, the CPe and cortical hem are linked by shared expression of members of the Bmp and Msx gene families...
- Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathwayE S Monuki
Division of Neurogenetics, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Neuron 32:591-604. 2001..These findings provide evidence for the roof plate as an organizing center of the developing cortex and for a roof plate-Lhx2 pathway in cortical patterning...
- Neuropeptide Y expression and function during osteoblast differentiation--insights from transthyretin knockout miceAna F Nunes
Nerve Regeneration, IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal
FEBS J 277:263-75. 2010..Using transthyretin (TTR) KO mice as a model of augmented NPY levels, we showed that this strain has increased NPY content in the ..
- Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective?Xinyi Li
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 31:12483-90. 2011b>Transthyretin (TTR), a systemic amyloid precursor in the human TTR amyloidoses, interacts with β-amyloid (Aβ) in vitro, inhibits Aβ fibril formation, and suppresses the Alzheimer's disease (AD) phenotype in APP23 mice bearing a human ..
- A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18M J Justice
Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
Genomics 13:1281-8. 1992..It also provides molecular access to many regions of mouse chromosome 18 for the first time...
- Location of the 9257 and ataxia mutations on mouse chromosome 18A J Griffith
Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor 48109 0618, USA
Mamm Genome 7:417-9. 1996..Two polymorphic microsatellite markers for proximal Chr 18 are described, D18Umi1 and D18Umi2. The Lama3 locus encoding the alpha 3 subunit of nicein was mapped distal to ataxia and did not recombine with Tg9257...
- Linkage map of seven polymorphic markers on rat chromosome 18E F Remmers
Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892
Mamm Genome 4:265-70. 1993..the markers described were defined by simple sequence length polymorphisms (SSLPs) associated with five genes: transthyretin (TTR), trypsin inhibitor-like protein (TILP), beta 2 adrenergic receptor (ADRB2), olfactory neuron-specific G ..
- An essential role in liver development for transcription factor XBP-1A M Reimold
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115 USA
Genes Dev 14:152-7. 2000..Therefore, XBP-1 is a transcription factor essential for hepatocyte growth...
- Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: a possible model for senile systemic amyloidosisM H Teng
Research Service, New York Department of Veterans Affairs Medical Center, New York, USA
Lab Invest 81:385-96. 2001The human serum protein transthyretin (TTR) is highly fibrillogenic in vitro and is the fibril precursor in both autosomal dominant (familial amyloidotic polyneuropathy [FAP] and familial amyloidotic cardiomyopathy [FAC]) and sporadic (..
- Retinal anatomy and function of the transthyretin null mouseB V Bui
Department of Optometry and Vision Sciences, The University of Melbourne, Carlton 3053, Victoria, Australia
Exp Eye Res 73:651-9. 2001..The purpose of this project was to characterize the retinal anatomy and function of the transthyretin (TTR) null mouse. Mice lacking TTR have been constructed by homologous recombination...
- BMP ligands act redundantly to pattern the dorsal telencephalic midlineJean M Hebert
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Genesis 35:214-9. 2003....
- nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal developmentSeiki Haraguchi
Department of Microbiology, Shiga University of Medical Science, Seta, Otsu, 520 2192 Shiga, Japan
Mech Dev 120:721-31. 2003..The nanos1 -deficient mice develop to term without any detectable abnormality and they are fertile. No significant neural defect is observed in terms of their behavior to date...
- Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreasRoque Bort
Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Aveue, Philadelphia, PA 19111, USA
Development 131:797-806. 2004..Other endodermal transcription factors may also function morphogenetically rather than by directly regulating tissue-specific programs...
- Microarray analysis of the effects of a gamma-protein kinase C null mutation on gene expression in striatum: a role for transthyretin in mutant phenotypesAmy M Smith
Institute for Behavioral Genetics, University of Colorado, 447, UCB, Boulder, CO 80309, USA
Behav Genet 36:869-81. 2006..Confirmation studies using qRT-PCR indicated that the expression of transthyretin was increased about 8-fold in striatum of naïve mutants compared to wild types...
- Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephalyXi Huang
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4114 MRB III, Nashville, TN 37232, USA
Hum Mol Genet 16:1454-68. 2007..We propose that elevated ectopic Shh signaling can impair dorsal telencephalic midline morphogenesis, and lead to non-cleavage of midline structures mimicking human HPE with dorsal midline defects...
- GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretionSherry Wanderling
Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
Mol Biol Cell 18:3764-75. 2007..The data identify insulin-like growth factor II as one developmentally important protein whose production depends on the activity of GRP94...
- Transthyretin enhances nerve regenerationCarolina E Fleming
Instituto de Biologia Molecular e Celular IBMC, Molecular Neurobiology Group, Porto, Portugal
J Neurochem 103:831-9. 2007Mutations in transthyretin (TTR) are associated with familial amyloid polyneuropathy, a neurodegenerative disorder characterized by TTR deposition in the PNS...
- 17beta-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathwayT Quintela
Health Sciences Research Centre, CICS, University of Beira Interior, Av Infante D Henrique, Covilha, Portugal
Cell Mol Neurobiol 29:475-83. 2009Oestrogen protects against AD by multiple mechanisms, including the enhancement of Abeta clearance. Transthyretin (TTR) is a homotetrameric protein mainly synthesized by the liver and choroid plexus (CP) of the brain that sequesters the ..
- Transthyretin mouse transgenes direct RFP expression or Cre-mediated recombination throughout the visceral endodermGloria S Kwon
Sloan Kettering Institute, New York, New York 10065, USA
Genesis 47:447-55. 2009b>Transthyretin (Ttr) is a thyroid hormone transport protein secreted by cells of the visceral yolk sac and fetal liver in developing embryos, and by hepatocytes and the choroid plexus epithelium of the brain in adult mice...
- Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalizationYusuke Sakurai
Laboratory for Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
Dev Biol 347:392-403. 2010..In contrast, the medial pallium requires Otx1 and Otx2 for its development later than E9.5, and the Otx2 expression in diencepalon and mesencephalon later than E9.5 is also directed by an enhancer other than FM1 and FM2 enhancers...
- CSF transthyretin neuroprotection in a mouse model of brain ischemiaSofia Duque Santos
Molecular Neurobiology Unit, Institute for Molecular and Cell Biology IBMC, Porto, Portugal
J Neurochem 115:1434-44. 2010..Using this model, we studied the influence of transthyretin in ischemic stroke...
- Transthyretin binds to glucose-regulated proteins and is subjected to endocytosis by the pancreatic β-cellNancy Dekki
The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Cell Mol Life Sci 69:1733-43. 2012b>Transthyretin (TTR) is a functional protein in the pancreatic β-cell. It promotes insulin release and protects against β-cell death...
- Liver retinol transporter and receptor for serum retinol-binding protein (RBP4)Philomena Alapatt
Molecular Medicine Program and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Utah, Salt Lake City, Utah 84112, USA
J Biol Chem 288:1250-65. 2013..In addition, expression of RBPR2 in liver and fat suggests a possible role in mediating established metabolic actions of RBP4 in those tissues...
- Lhx2 regulates the development of the forebrain hem systemAchira Roy
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India
Cereb Cortex 24:1361-72. 2014..Since all components of the forebrain hem system have been identified across several vertebrate species, the mechanisms that regulate them may have played a fundamental role in driving key aspects of forebrain evolution. ..
- Hepatic production of transthyretin L12P leads to intracellular lysosomal aggregates in a new somatic transgenic mouse modelAna Rita Batista
Molecular Neurobiology, IBMC Instituto de Biologia Molecular e Celular, Porto, Portugal
Biochim Biophys Acta 1832:1183-93. 2013b>Transthyretin (TTR) is a plasma and cerebrospinal fluid (CSF)-circulating homotetrameric protein. More than 100 point mutations have been identified in the TTR gene and several are related with amyloid diseases...
- Fibroblasts endocytose and degrade transthyretin aggregates in transthyretin-related amyloidosisYohei Misumi
Molecular Neurobiology, IBMC Instituto de Biologia Molecular e Celular, Porto, Portugal
Lab Invest 93:911-20. 2013b>Transthyretin (TTR)-related amyloidosis is a fatal disorder characterized by systemic extracellular deposition of TTR amyloid fibrils...
- The inflammatory response to sciatic nerve injury in a familial amyloidotic polyneuropathy mouse modelNádia Pereira Gonçalves
Molecular Neurobiology, Instituto de Biologia Molecular e Celular IBMC, Porto 4150 180, Portugal Instituto de Ciências Biomédicas de Abel Salazar ICBAS, Universidade do Porto, Porto 4050 313, Portugal
Exp Neurol 257:76-87. 2014..FAP is associated with extracellular deposition of mutant transthyretin (TTR), leading to degeneration of cells and tissues, particularly in the peripheral nervous system (PNS)...
- The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model miceXin Wang
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, and
J Neurosci 34:7253-65. 2014Increased neuronal synthesis of transthyretin (TTR) may favorably impact on Alzheimer's disease (AD) because TTR has been shown to inhibit Aβ aggregation and detoxify cell-damaging conformers...
- Patterns of gene expression associated with Pten deficiency in the developing inner earHyung Jin Kim
Division of Intractable Diseases, Center for Biomedical Sciences, National Institute of Health, Chungcheongbuk Do, South Korea
PLoS ONE 9:e97544. 2014..From this study, we suggest two key regulatory signaling networks mediated by Spp1 and Rgs4, which may play potential roles in neuronal differentiation of developing auditory neurons. ..
- Transthyretin Induces Insulin-like Growth Factor I Nuclear Translocation Regulating Its Levels in the HippocampusMarta Vieira
Molecular Neurobiology Unit, IBMC Instituto de Biologia Molecular e Celular, Rua do Campo Alegre 823, 4150 180, Porto, Portugal
Mol Neurobiol 51:1468-79. 2015b>Transthyretin (TTR) is the carrier protein of thyroxine (T4) and binds to retinol-binding protein (RBP)-retinol complex. It is mainly synthesized by both liver and choroid plexuses of the brain...
- CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein lociYanshuang Mu
Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan College of Life Sciences, Northeast Agriculture University, Harbin, China
FEBS Lett 589:849-56. 2015Familial amyloidotic polyneuropathy is one type of protein misfolding disease. Transthyretin (TTR) tetramer dissociation is the limiting step for amyloid fibril formation...
- Expression and functional analysis of the Wnt/beta-catenin induced mir-135a-2 locus in embryonic forebrain developmentGiuliana Caronia-Brown
Department of Neurology and Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, 7 113 Lurie Bldg, 303 E Superior Street, Chicago, IL, 60611, USA
Neural Dev 11:9. 2016..Here, we investigated the role of miR-135a, derived from the mir-135a-2 locus, in embryonic forebrain development...
- TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissuesMaho Shibata
Department of Molecular Biology and Genetics, Cornell University, 526 Campus Road, Ithaca, NY 14853, USA
Development 138:5333-43. 2011....
- The mutation in Chd7 causes misexpression of Bmp4 and developmental defects in telencephalic midlineXuan Jiang
Key Laboratory of Model Animal for Disease Study of Ministry of Education, Model Animal Research Center, Nanjing University, Nanjing, China
Am J Pathol 181:626-41. 2012..These studies provide novel insight into pathogenesis of CNS anomalies in CHARGE syndrome...
- Dietary curcumin counteracts extracellular transthyretin deposition: insights on the mechanism of amyloid inhibitionNelson Ferreira
IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
Biochim Biophys Acta 1832:39-45. 2013The transthyretin amyloidoses (ATTR) are devastating diseases characterized by progressive neuropathy and/or cardiomyopathy for which novel therapeutic strategies are needed...
- Six3 is required for ependymal cell maturationAlfonso Lavado
Department of Genetics, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
Development 138:5291-300. 2011..In its absence, ependymal cells fail to suppress radial glia characteristics, resulting in a defective lateral wall, abnormal neuroblast migration and differentiation, and hydrocephaly...
- Transthyretin blocks retinol uptake and cell signaling by the holo-retinol-binding protein receptor STRA6Daniel C Berry
Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Mol Cell Biol 32:3851-9. 2012..In turn, holo-RBP associates in plasma with transthyretin (TTR) to form a ternary RBP-retinol-TTR complex...
- Novel function of transthyretin in pancreatic alpha cellsYu Su
Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University Hospital, Kumamoto, Japan
FEBS Lett 586:4215-22. 2012Although transthyretin (TTR) is expressed in pancreatic alpha (glucagon) cells in the islets of Langerhans, the function of TTR in pancreatic alpha cells remains unknown...
- mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortexAllissa A Dillman
Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
Nat Neurosci 16:499-506. 2013..We provide this data set and analysis as a resource for understanding gene expression in the embryonic and adult cerebral cortex...
- Transthyretin regulates hippocampal 14-3-3ζ protein levelsMarta Vieira
Molecular Neurobiology Unit, IBMC Instituto de Biologia Molecular e Celular, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
FEBS Lett 587:1482-8. 2013b>Transthyretin is the carrier protein of thyroxine and retinol in plasma and cerebrospinal fluid and has been described also as a neuroprotective molecule...
- Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental rolesS Cereghini
Unité de Génétique de la Différenciation, UA 1149 du CNRS, Institut Pasteur, Paris, France
Development 116:783-97. 1992..of vHNF1 mRNA are present in the visceral extraembryonic endoderm, which co-localize with transcripts of the transthyretin gene...
- Chromosomal localization of the mouse prealbumin gene (Ttr) by in situ hybridizationH Qiu
Department of Medical Genetics, Chinese Academy of Medical Sciences, Beijing
Cytogenet Cell Genet 61:186-8. 1992b>Prealbumin is a serum protein which plays an important role in plasma transport of retinol and thyroxine. The accumulation of a variant prealbumin is associated with a hereditary disorder, familial amyloidotic polyneuropathy (FAP)...
- Structure and expression of the mouse prealbumin geneS Wakasugi
J Biochem 100:49-58. 1986We cloned a genomic DNA fragment which covers the entire sequence of the mouse prealbumin gene and then studied the structure...
- Prealbumin gene expression during mouse development studied by in situ hybridizationT Murakami
Department of Biochemistry, Kumamoto University Medical School, Japan
Cell Differ 22:1-9. 1987Localization of prealbumin mRNA in tissues from mice at various stages of gestation was investigated using in situ hybridization procedures. Prealbumin mRNA was detected as early as the 10th day of gestation...
- Mouse chromosomal location of three EGF receptor ligands: amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF (Hegfl)B G Pathak
Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
Genomics 28:116-8. 1995..These results confirm and extend known relationships between mouse and human chromosomes, and they also provide new information regarding the evolution of this important gene family...
- Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombinationS Wei
Institute of Human Nutrition, Columbia University, New York, New York 10032
J Biol Chem 270:866-70. 1995..plasma transport protein, retinol-binding protein (RBP), which circulates as a 1-to-1 protein complex with transthyretin (TTR)...
- Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18R S Buxton
Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London, United Kingdom
Genomics 21:510-6. 1994..We further show that the human DSC3 gene, previously reported to be located on chromosome 9, also maps to human chromosome 18...
- Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormoneV Episkopou
Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032
Proc Natl Acad Sci U S A 90:2375-9. 1993b>Transthyretin (TTR) is thought to play a major role in vitamin A metabolism and thyroid hormone transport in mammals...
- A replacement vector used to introduce subtle mutations into mouse genesK Horie
Department of Medical Genetics, Osaka University, Japan
Gene 166:197-204. 1995..for introducing subtle mutations into various mouse genes has been developed using, a model system, the mouse transthyretin-encoding gene (ttr) and mouse embryonal carcinoma F9 cells...
- The gene for transcription factor GATA-6 resides on mouse chromosome 18 and is expressed in myocardium and vascular smooth muscleN Narita
Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, 63110, USA
Genomics 36:345-8. 1996..Using backcross analysis, the Gata6 gene was localized to mouse chromosome 18, linked to the gene encoding transthyretin. RNase protection analysis showed that Gata6 is abundantly expressed in the heart, stomach, intestine, and ..
- Chromosomal localisation of genes coding for human and mouse liver cytosolic cysteine dioxygenaseS Jeremiah
Galton Laboratory, University College London, UK
Ann Hum Genet 60:29-33. 1996..Interspecific backcross mapping in the mouse indicated that Cdo, the mouse homologue of CDO, is situated in the central region of mouse chromosome 18 which shares a region of homology with human chromosome 5...
- Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryosS A Duncan
Laboratory of Molecular Cell Biology, The Rockefeller University, New York, New York 10021, USA
Development 124:279-87. 1997..in the VE, required for normal expression of secreted factors including alphafetoprotein, apolipoproteins, transthyretin, retinol binding protein, and transferrin...
- The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoformJ H Miner
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Cell Biol 137:685-701. 1997..Together, these results reveal remarkable diversity in BL composition and complexity in BL development...
- Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sacS M Farrington
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Mech Dev 62:197-211. 1997..Our results suggest that similar mechanisms may be utilized to mediate inductive interactions in both extraembryonic and embryonic tissues...
- The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreasF Rausa
Department of Biochemistry and Molecular Biology, University of Illinois at Chicago 60612 7334, USA
Dev Biol 192:228-46. 1997..HNF-6 activates expression of a reporter gene driven by the HNF-6 binding site from either the HNF-3 beta or transthyretin (TTR) promoter regions...
- In situ hybridization with 33P-labeled RNA probes for determination of cellular expression patterns of liver transcription factors in mouse embryosF M Rausa
Department of Biochemistry and Molecular Biology, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, 60612 7334, USA
Methods 16:29-41. 1998..We discuss these expression patterns with respect to specification of hepatocytes and differentiation of the endocrine and exocrine pancreas...
- Chromosomal localization reveals three kinesin heavy chain genes in mouseCh Xia
Division of Cellular and Molecular Medicine, Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0683, USA
Genomics 52:209-13. 1998..Kif5a, Kif5b, and Kif5c map to mouse chromosomes 10, 18, and 2; Kif5a and Kif5c appear to be expressed only in neuronal tissues by Northern blot analysis while Kif5b appears to be ubiquitous in its expression...
- Genetic mapping of mouse heat shock protein genes Hsc4a to chromosome 11 and Hsc74 to chromosome 18 and two Hsc74 pseudogenes to chromosomes X and 8C R Hunt
Washington University School of Medicine, St Louis, Missouri 63108
Genomics 56:358-60. 1999
- Retinol and retinol-binding protein: gut integrity and circulating immunoglobulinsL Quadro
Institute of Cancer Researc, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Infect Dis 182:S97-S102. 2000..No differences were observed in B and T cell populations present in spleen, thymus, and bone marrow...
- Biochemical basis for depressed serum retinol levels in transthyretin-deficient mice- van Bennekum AM
Institute of Human Nutrition, The Department of Medicine, and the Institute of Cancer Research of the College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 276:1107-13. 2001b>Transthyretin (TTR) acts physiologically in the transport of retinol in the circulation. We previously reported the generation and partial characterization of TTR-deficient (TTR(-)) mice...
- Thyroid hormone distribution in the mouse brain: the role of transthyretinJ A Palha
Unidade de Amiloide, Instituto de Biologia Molecular e Celular, Rua do Campo Alegre, 823, 4150 180 Porto, Portugal
Neuroscience 113:837-47. 2002b>Transthyretin is the major thyroxine-binding protein in the plasma of rodents, and the main thyroxine-binding protein in the cerebrospinal fluid of both rodents and humans...
- BMP signaling is required locally to pattern the dorsal telencephalic midlineJean M Hebert
Department of Biological Sciences, Stanford University, 385 Serra Mall, CA 94305, USA
Neuron 35:1029-41. 2002..Our data fail to support a more global, concentration-dependent role in specifying telencephalic cell fates...
- Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55ProMónica Mendes Sousa
Amyloid Unit, Instituto de Biologia Molecular e Celular, Porto, Portugal
Am J Pathol 161:1935-48. 2002..FAP) is a lethal autosomal dominant disorder characterized by systemic extracellular deposition of transthyretin (TTR) amyloid fibrils...
- The isthmic neuroepithelium is essential for cerebellar midline fusionAngeliki Louvi
Régionalisation Nerveuse CNRS ENS UMR 8542, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
Development 130:5319-30. 2003....
- Transthyretin is involved in depression-like behaviour and exploratory activityJoão Carlos Sousa
Institute for Molecular and Cell Biology, Porto, Portugal
J Neurochem 88:1052-8. 2004b>Transthyretin (TTR), the major transporter of thyroid hormones and vitamin A in cerebrospinal fluid (CSF), binds the Alzheimer beta-peptide and thus might confer protection against neurodegeneration...
- An enhancer element at the Igf2/H19 locus drives gene expression in both imprinted and non-imprinted tissuesMarika Charalambous
Developmental Biology Program, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
Dev Biol 271:488-97. 2004..The presence of an enhancer for imprinted tissues in the intergenic region argues for the existence of imprinting controls distinct from the DMD, which may be provided by differential methylation at sites proximal to Igf2...
- Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesisThor D Stein
Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
J Neurosci 24:7707-17. 2004..Antibody interference and small interfering RNA knock-down demonstrate that the sAPPalpha-driven expression of transthyretin and insulin-like growth factor 2 is necessary for protection against Abeta-induced neuronal death...
- FoxA proteins regulate H19 endoderm enhancer E1 and exhibit developmental changes in enhancer binding in vivoLingyun Long
Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose St, Lexington, KY 40536 0298, USA
Mol Cell Biol 24:9601-9. 2004..These data also indicate that the presence of FoxA proteins is not sufficient for binding but that additional mechanisms must govern the accessibility of FoxA proteins to their cognate binding sites within the H19 E1 enhancer...
- Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial palliumLuca Muzio
Department of Biological and Technological Research, San Raffaele Scientific Institute, 20132 Milan, Italy
J Neurosci 25:4435-41. 2005..Remarkably, in the absence of Foxg1, additional inactivation of the medial fates promoter Emx2, although not suppressing cortical specification, conversely rescues overproduction of Reelin(on) neurons...
- Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with developmentAdam Swetloff
Developmental Biology Unit, Institute of Child Health, UCL, London, UK
Int J Dev Biol 49:859-65. 2005....
- Transthyretin knockouts are a new mouse model for increased neuropeptide YAna Filipa Nunes
Molecular Neurobiology, Instituto de Biologia Molecular e Celular IBMC, Porto, Portugal
FASEB J 20:166-8. 2006b>Transthyretin (TTR) has access to the brain and nerve through the blood and cerebrospinal fluid...
- Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice modelI Cardoso
Molecular Neurobiology, IBMC, Porto University, Porto, Portugal
FASEB J 20:234-9. 2006..polyneuropathy is an autosomal dominant disorder mainly characterized by the extracellular deposition of transthyretin, with special involvement of the peripheral nerve...
- Transthyretin and Alzheimer's disease: where in the brain?João Carlos Sousa
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
Neurobiol Aging 28:713-8. 2007b>Transthyretin (TTR), a carrier protein for thyroxine and retinol in plasma and cerebrospinal fluid (CSF), has been shown to bind the amyloid beta peptide...
- Transthyretin: a key gene involved in the maintenance of memory capacities during agingJonathan Brouillette
Department of Neurology and Neurosurgery, Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada H4H 1R3
Neurobiol Aging 29:1721-32. 2008..We found that alterations in hippocampal gene expression of transthyretin (TTR), calcineurin, and NAD(P)H dehydrogenase quinone 2 (NQO2) were associated with memory deficits in aged ..
- Cell division and apoptosis in the adult neural stem cell niche are differentially affected in transthyretin null miceSamantha J Richardson
UMR CNRS 5166, Evolution des Regulations Endocriniennes, Museum national d histoire naturelle, 7 rue Cuvier, 75231 Paris, France
Neurosci Lett 421:234-8. 2007..b>Transthyretin (TTR) is a TH distributor protein in the blood and cerebrospinal fluid...
- The absence of transthyretin does not impair regulation of lipid and glucose metabolismF Marques
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
Horm Metab Res 39:529-33. 2007Increased levels of neuropeptide Y have been reported in transthyretin-null mice...
- ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicityMárcia Almeida Liz
Molecular Neurobiology Group, Instituto de Biologia Molecular e Celular IBMC, Porto, Portugal
J Lipid Res 48:2385-95. 2007A fraction of plasma transthyretin (TTR) circulates in HDL through binding to apolipoprotein A-I (apoA-I). Moreover, TTR is able to cleave the C terminus of lipid-free apoA-I...
- Impairment of the ubiquitin-proteasome system associated with extracellular transthyretin aggregates in familial amyloidotic polyneuropathyS D Santos
Molecular Neurobiology Unit, Institute of Molecular and Cell Biology, University of Porto, Portugal
J Pathol 213:200-9. 2007..amyloidotic polyneuropathy (FAP), a neurodegenerative disorder caused by extracellular deposition of mutant transthyretin (TTR)...
- Molecularly and temporally separable lineages form the hindbrain roof plate and contribute differentially to the choroid plexusNina L Hunter
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Development 134:3449-60. 2007....
- Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicityJoel N Buxbaum
Division of Rheumatology Research, W M Keck Autoimmune Disease Center, and Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 105:2681-6. 2008..interactions that could constitute native mechanisms of neuroprotection in vivo, overexpression of a WT human transthyretin (TTR) transgene was ameliorative in the APP23 transgenic murine model of human AD...
- Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob miceNimesh Mody
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Am J Physiol Endocrinol Metab 294:E785-93. 2008..RBP4 normally binds to the larger transthyretin (TTR) homotetramer, forming a protein complex that reduces renal clearance of RBP4...
- The transthyretin gene is expressed in human and rodent dorsal root gangliaTatsufumi Murakami
Division of Neurology, Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701 0192, Japan
Neurosci Lett 436:335-9. 2008The transthyretin (TTR) gene is mainly expressed in the liver and choroid plexus of the brain...
- Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosineMinoru Tomizawa
Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba City, Chiba, 260 8670, Japan
Cell Tissue Res 333:17-27. 2008..These cells were positive for indocyanine green uptake and for mRNAs of albumin, transthyretin, and alpha-feto protein, but negative for mRNAs of tyrosine aminotransferase, alpha1-antitrypsin, glucose-6-..
- 5Alpha-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathwayT Quintela
Health Sciences Research Centre CICS, University of Beira Interior, Av Infante D Henrique, 6200 506 Covilha, Portugal
Brain Res 1229:18-26. 2008b>Transthyretin (TTR) is a 55 kDa plasma homotetrameric protein mainly synthesized in the liver and choroid plexuses (CPs) of the brain that, functions as a carrier for thyroxin and retinol binding protein...
- Global gene expression analysis of cranial neural tubes in embryos of diabetic miceBoran Jiang
Molecular Neurobiology Laboratory, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
J Neurosci Res 86:3481-93. 2008..perturbed the development of choroid plexus and ventricular systems and reduced the production of proteins such as Ttr and Igf2 in the developing brain, indicating that these changes could impair the survival and proliferation of ..
- Transthyretin is not expressed by dorsal root ganglia cellsMónica Mendes Sousa
Nerve Regeneration Group, Instituto de Biologia Molecular e Celular IBMC, Portugal
Exp Neurol 214:362-5. 2008Several mutations in transthyretin (TTR) are related to familial amyloidotic polyneuropathy (FAP), a neurodegenerative disorder caused by extracellular deposition of TTR fibrils, particularly in the peripheral nervous system (PNS)...
- Substrate specificity of transthyretin: identification of natural substrates in the nervous systemMárcia A Liz
Nerve Regeneration Group, Instituto de Biologia Molecular e Celular IBMC, Rua do Campo Alegre, 823, 4150 180 Porto, Portugal
Biochem J 419:467-74. 2009Besides functioning as the plasma transporter of retinol and thyroxine, TTR (transthyretin) is a protease, cleaving apoA-I (apolipoprotein A-I) after a phenylalanine residue...
- Asymmetric expression patterns of brain transthyretin in normal mice and a transgenic mouse model of Alzheimer's diseaseK J Tsai
Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan
Neuroscience 159:638-46. 2009Brain asymmetry is linked with several neurological diseases, and transthyretin (TTR) is a protein sequestering beta-amyloid (Abeta) and helping to prevent the Alzheimer's disease (AD)...
- Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activityCarolina E Fleming
Instituto de Biologia Molecular e Celular IBMC, Nerve Regeneration Group and Molecular Neurobiology Group, 4150 180 Porto, Portugal
J Neurosci 29:3220-32. 2009Mutated transthyretin (TTR) causes familial amyloid polyneuropathy, a neurodegenerative disorder characterized by TTR deposition in the peripheral nervous system (PNS). The origin/reason for TTR deposition in the nerve is unknown...
- FGF signaling is strictly required to maintain early telencephalic precursor cell survivalHunki Paek
Departments of Neuroscience and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Development 136:2457-65. 2009....
- FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformationKimberly A Aldinger
Committee on Neurobiology, University of Chicago, Chicago, Illinois, USA
Nat Genet 41:1037-42. 2009..Our results highlight a previously unrecognized role for mesenchyme-neuroepithelium interactions in the mid-hindbrain during early embryogenesis...
- Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexusCorinne M Nielsen
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Dev Biol 340:430-7. 2010....
- Progesterone receptor-mediated up-regulation of transthyretin in preimplantation mouse uterusHonglu Diao
Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA
Fertil Steril 93:2750-3. 2010b>Transthyretin (TTR), a carrier for thyroxine and retinol, has its messenger RNA (mRNA) expressed in the glandular endometrial epithelium and its protein detected in the glandular endometrial epithelium and the uterine lumen...
- Enhanced expression of human cDNA by phosphoglycerate kinase promoter-puromycin cassette in the mouse transthyretin locusZhenghua Li
Division of Developmental Genetics, Center for Animal Resources and Development, Institute of Resource Development and Analysis, Kumamoto University, 2 2 1 Honjo, Kumamoto, 860 0811, Japan
Transgenic Res 20:191-200. 2011..the PGK-neo cassette, flanked by lox71 and loxP, was inserted into the first exon of the mouse endogenous transthyretin (Ttr) gene in ES cells...
- Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APPHongmei Li
Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 107:17362-7. 2010..Using transcriptional profiling, we now identify transthyretin (TTR) and Klotho as APP/APLP2-dependent genes whose expression is decreased in loss-of-function states but ..
- The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesisMaho Shibata
Department of Molecular Biology and Genetics, Cornell University, 259 Biotechnology Building, Ithaca, NY 14853, USA
Dev Biol 349:331-41. 2011..Our results support previously undescribed roles of the extraembryonic mesoderm in yolk sac morphogenesis and in the closure of the ectoplacental cavity and identify a novel role of ZFP568 in the development of extraembryonic tissues...
- Changes in the expression of transthyretin and protein kinase Cγ genes in the prefrontal cortex in response to naltrexoneJaehak Yu
Department of Neuropsychiatry, Konkuk University School of Medicine, Seoul, Republic of Korea
Neurosci Lett 488:288-93. 2011..using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) revealed that the expression of transthyretin (TTR) and protein kinase C (PKC)γ were increased in the PFC but not in the hippocampus of naltrexone-treated ..
- The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytesJames Harper
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
Proc Natl Acad Sci U S A 108:10585-90. 2011..In contrast, those required for processing maternal milk were markedly reduced. Thus, we conclude Blimp1 governs the developmental switch responsible for postnatal intestinal maturation...
- Capacity to form choroid plexus-like cells in vitro is restricted to specific regions of the mouse neural ectodermT Thomas
Centre for Early Human Development, Monash Medical Centre, Clayton, Victoria, Australia
Development 117:253-62. 1993..These results suggest that the division of neural ectoderm into segments which contain discrete stem cell populations may be a general feature of the early phase of development of the central nervous system...
- Seven genes from human chromosome 18 map to chromosome 24 in the bovineN J Larsen
Department of Animal Sciences, University of Wisconsin, Madison 53706, USA
Cytogenet Cell Genet 73:184-6. 1996..and melanocortin-2 receptor (MC2R) from the short arm of human chromosome (HSA) 18 and N-cadherin (CDH2), transthyretin (TTR), gastrin-releasing peptide (GRP), and plasminogen activator inhibitor 2 (PAI2) from the long arm of HSA ..
- TRANSTHYRETIN DEPOSITION IN AGING TRANSGENIC MICEJoel Buxbaum; Fiscal Year: 2004..Islet Amyloid Polypeptide), Alzheimer's Disease (AbetaPP), Aortic Amyloid (ApoA1) and Senile Cardiac Amyloid (Transthyretin), occur with increasing frequency with increasing age...
- 6th International Symposium on FAP Disorders and 5th...Joel Buxbaum; Fiscal Year: 2006..Sixth International Workshop on The Familial Amyloidotic Polyneuropathies and Cardiomyopathies and Other Transthyretin Related Disorders and the Fifth International Workshop of Liver Transplantation in Familial Amyloid ..
- FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATIONKLAUS KAESTNER; Fiscal Year: 2003....
- Expression profiling of human isletsKLAUS KAESTNER; Fiscal Year: 2006....
- Development of C57BL/6 ES cell technology for high thoughput use.KLAUS KAESTNER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- FUNCTIONAL GENOMICS OF THE BETA-CELLKLAUS KAESTNER; Fiscal Year: 2007..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
- Liver Biology, Development and DiseaseKLAUS KAESTNER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..