Genomes and Genes
Gene Symbol: Tubb3
Description: tubulin, beta 3 class III
Alias: 3200002H15Rik, M(beta)3, M(beta)6, tubulin beta-3 chain, betaIII-tubulin
- Gil Sanz C, Landeira B, Ramos C, Costa M, M ller U. Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon. J Neurosci. 2014;34:10475-87 pubmed publisher..Our findings suggest that defects in adherens junctions components in mice massively affects progenitor cell proliferation and leads to a double cortex-like phenotype...
- Rogers S, Gahring L. Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy. PLoS ONE. 2012;7:e36467 pubmed publisher..These results demonstrate distinct and varied spatiotemporal expression of alpha7 during tooth development, and they suggest that dysfunction of this receptor would have diverse impacts upon the adult organ. ..
- Cappello S, Böhringer C, Bergami M, Conzelmann K, Ghanem A, Tomassy G, et al. A radial glia-specific role of RhoA in double cortex formation. Neuron. 2012;73:911-24 pubmed publisher..These data not only demonstrate that RhoA is largely dispensable for migration in neurons but also showed that defects in radial glial cells, rather than neurons, can be sufficient to produce SBH. ..
- Jeong S, Luo R, Li S, Strokes N, Piao X. Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex. J Comp Neurol. 2012;520:2930-40 pubmed publisher..However, the correlation between GPR56 expression in neurons at E10.5-E11.5 and the anatomic distribution of the cortical malformation in both humans and mice suggests that its function in preplate neurons is indispensible. ..
- Fujiwara H, Ferreira M, Donati G, MARCIANO D, Linton J, Sato Y, et al. The basement membrane of hair follicle stem cells is a muscle cell niche. Cell. 2011;144:577-89 pubmed publisher..Thus, bulge stem cells, via nephronectin expression, create a smooth muscle cell niche and act as tendon cells for the APM. Our results reveal a functional role for basement membrane heterogeneity in tissue patterning. PAPERCLIP: ..
- Dominguez Frutos E, López Hernández I, Vendrell V, Neves J, Gallozzi M, Gutsche K, et al. N-myc controls proliferation, morphogenesis, and patterning of the inner ear. J Neurosci. 2011;31:7178-89 pubmed publisher..Collectively, our data suggest that N-myc regulates growth, morphogenesis, and pattern formation during the development of the inner ear. ..
- Luo R, Jeong S, Jin Z, Strokes N, Li S, Piao X. G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. Proc Natl Acad Sci U S A. 2011;108:12925-30 pubmed publisher..Thus, collagen III regulates the proper lamination of the cerebral cortex by acting as the major ligand of GPR56 in the developing brain. ..
- Ferron S, Charalambous M, Radford E, McEwen K, Wildner H, Hind E, et al. Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis. Nature. 2011;475:381-5 pubmed publisher....
- Kim M, Roesener A, Mendonca P, Mastick G. Robo1 and Robo2 have distinct roles in pioneer longitudinal axon guidance. Dev Biol. 2011;358:181-8 pubmed publisher..Therefore, while Robo1 and 2 have some genetic overlap to cooperate in guiding longitudinal axons, each isoform has distinct functions in specific longitudinal axon populations. ..
- Ogata Iwao M, Inatani M, Iwao K, Takihara Y, Nakaishi Fukuchi Y, Irie F, et al. Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cells. Invest Ophthalmol Vis Sci. 2011;52:6671-9 pubmed publisher....
- Gatz S, Ju L, Gruber R, Hoffmann E, Carr A, Wang Z, et al. Requirement for DNA ligase IV during embryonic neuronal development. J Neurosci. 2011;31:10088-100 pubmed publisher..The VZ/SVZ, in contrast, is highly sensitive to acute radiation-induced DSB formation. ..
- De Gendt K, Denolet E, Willems A, Daniëls V, Clinckemalie L, Denayer S, et al. Expression of Tubb3, a beta-tubulin isotype, is regulated by androgens in mouse and rat Sertoli cells. Biol Reprod. 2011;85:934-45 pubmed publisher..Here, we found that one of these components, the beta-tubulin isotype Tubb3, is differentially regulated in testes from SCARKO mice (relative to littermate controls) from Postnatal Day 10 to ..
- Higginbotham H, Guo J, Yokota Y, Umberger N, Su C, Li J, et al. Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation. Nat Neurosci. 2013;16:1000-7 pubmed publisher....
- Patel A, Krimm R. Neurotrophin-4 regulates the survival of gustatory neurons earlier in development using a different mechanism than brain-derived neurotrophic factor. Dev Biol. 2012;365:50-60 pubmed publisher..Therefore, compared to BDNF, NT-4 plays distinct roles in gustatory development; differences include timing, source of neurotrophin, and mechanism of action. ..
- Postiglione M, Jüschke C, Xie Y, Haas G, Charalambous C, Knoblich J. Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortex. Neuron. 2011;72:269-84 pubmed publisher..Our results indicate that the orientation of progenitor cell divisions is important for correct lineage specification in the developing mammalian brain. ..
- Wei H, Lang M, Jiang X. Calretinin is expressed in the intermediate cells during olfactory receptor neuron development. Neurosci Lett. 2013;542:42-6 pubmed publisher..Therefore, calretinin can serve as a marker of the intermediate ORNs. With this discovery, future studies can use calretinin as a tool to define these intermediate ORNs during olfactory neurogenesis. ..
- Cariboni A, Davidson K, Dozio E, Memi F, Schwarz Q, Stossi F, et al. VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development. 2011;138:3723-33 pubmed publisher..Thus, the loss of both neuropilin ligands leads to an almost complete failure to establish the GnRH neuron system. ..
- Ngan E, Garcia Barcelo M, Yip B, Poon H, Lau S, Kwok C, et al. Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans. J Clin Invest. 2011;121:3467-78 pubmed publisher..Collectively, we defined PTCH1 and DLL3 as HSCR susceptibility genes and suggest that Hedgehog/Notch-induced premature gliogenesis may represent a new disease mechanism for HSCR. ..
- Broders Bondon F, Paul Gilloteaux P, Carlier C, Radice G, Dufour S. N-cadherin and β1-integrins cooperate during the development of the enteric nervous system. Dev Biol. 2012;364:178-91 pubmed publisher..In conclusion, our data reveal that N-cadherin is not essential for ENS development but it does modulate the modes of ENCC migration and acts in concert with β1-integrin to control the proper development of the ENS. ..
- Erickson C, Zaitoun I, Haberman K, Gosain A, Druckenbrod N, Epstein M. Sacral neural crest-derived cells enter the aganglionic colon of Ednrb-/- mice along extrinsic nerve fibers. J Comp Neurol. 2012;520:620-32 pubmed publisher..Extrinsic nerve fibers serve as a route of entry for both rodent and avian sacral crest into the hindgut. ..
- Lee M, Yutzey K. Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves. PLoS ONE. 2011;6:e29758 pubmed publisher....
- Huang T, Krimm R. BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol. 2014;386:308-20 pubmed publisher..Spatial and temporal differences in BDNF and NT4 expression can regulate differential gene expression in vivo and determine their specific roles during development. ..
- Appler J, Lu C, Druckenbrod N, Yu W, Koundakjian E, Goodrich L. Gata3 is a critical regulator of cochlear wiring. J Neurosci. 2013;33:3679-91 pubmed publisher..As the first auditory-specific regulator of SGN development, Gata3 provides a useful molecular entry point for efforts to engineer SGNs for the restoration of hearing. ..
- George L, Chaverra M, Wolfe L, Thorne J, Close Davis M, Eibs A, et al. Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons. Proc Natl Acad Sci U S A. 2013;110:18698-703 pubmed publisher..In summary, these data suggest that FD does not result from a failure in trunk neural crest migration, but rather from a critical function for Ikbkap in TrkA progenitors and TrkA(+) neurons. ..
- Fei D, Krimm R. Taste neurons consist of both a large TrkB-receptor-dependent and a small TrkB-receptor-independent subpopulation. PLoS ONE. 2013;8:e83460 pubmed publisher..In addition, these remaining neurons do not express the TrkB receptor, which indicates that either BDNF or NT-4 must act via additional receptors to influence tongue innervation and/or targeting. ..
- Gil Sanz C, Franco S, Martinez Garay I, Espinosa A, Harkins Perry S, Muller U. Cajal-Retzius cells instruct neuronal migration by coincidence signaling between secreted and contact-dependent guidance cues. Neuron. 2013;79:461-77 pubmed publisher..Our findings identify nectins and afadin as components of the reelin signaling pathway and demonstrate that coincidence signaling between CR cell-derived secreted and short-range guidance cues direct neuronal migration. ..
- Das G, Choi Y, Sicinski P, Levine E. Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells. Neural Dev. 2009;4:15 pubmed publisher....
- Lawoko Kerali G, Rivolta M, Lawlor P, Cacciabue Rivolta D, Langton Hewer C, van Doorninck J, et al. GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear. Mech Dev. 2004;121:287-99 pubmed..In auditory neuroblasts, NeuroD appears to be dependent on the expression of GATA3. ..
- Bharti K, Liu W, Csermely T, Bertuzzi S, Arnheiter H. Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development. 2008;135:1169-78 pubmed publisher....
- Heng J, Nguyen L, Castro D, Zimmer C, Wildner H, Armant O, et al. Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature. 2008;455:114-8 pubmed publisher..Thus, a proneural protein controls the complex cellular behaviour of cell migration through a remarkably direct pathway involving the transcriptional activation of a small GTP-binding protein. ..
- Nakatani T, Mizuhara E, Minaki Y, Sakamoto Y, Ono Y. Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system. J Biol Chem. 2004;279:16356-67 pubmed..These results suggest that Helt acts as a transcriptional repressor to regulate neuronal differentiation and/or identity. ..
- Morcillo J, Martinez Morales J, Trousse F, Fermin Y, Sowden J, Bovolenta P. Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH. Development. 2006;133:3179-90 pubmed..Collectively, these data indicate that BMP7 is required for retinal fissure formation and that its activity is needed, before SHH signalling, for the generation of PAX2-positive cells at the optic disc. ..
- Tsarovina K, Pattyn A, Stubbusch J, Muller F, van der Wees J, Schneider C, et al. Essential role of Gata transcription factors in sympathetic neuron development. Development. 2004;131:4775-86 pubmed..The present data establish Gata2 and Gata3 in the chick and mouse, respectively, as essential members of the transcription factor network controlling sympathetic neuron development. ..
- Mao J, Kim B, Rajurkar M, Shivdasani R, McMahon A. Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development. 2010;137:1721-9 pubmed publisher..Together, these studies provide new insights into tissue interactions underlying mammalian gastrointestinal organogenesis and disease. ..
- Lee Y, Chong M, McKinnon P. Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status. J Neurosci. 2001;21:6687-93 pubmed..Furthermore, these data demonstrate that the differentiation status of neural cells is a critical determinant in the activation of certain apoptotic pathways. ..
- Kele J, Simplicio N, Ferri A, Mira H, Guillemot F, Arenas E, et al. Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons. Development. 2006;133:495-505 pubmed..These results demonstrate that Ngn2 is uniquely required for the development of midbrain dopaminergic neurons. ..
- Fukuda T, Tokunaga A, Sakamoto R, Yoshida N. Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. Mol Cell Neurosci. 2011;46:614-24 pubmed publisher..5 brain. Our findings suggest that the Fbxl10 gene makes important contributions to embryonic neural development by regulating cell proliferation and cell death in mice. ..
- Ferron S, Pozo N, Laguna A, Aranda S, Porlan E, Moreno M, et al. Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling. Cell Stem Cell. 2010;7:367-79 pubmed publisher..Finally, Dyrk1a heterozygous NSCs exhibit defects in self-renewal, EGF-dependent cell-fate decisions, and long-term persistence in vivo, suggesting that symmetrical divisions play a role in the maintenance of the SEZ reservoir. ..
- Hevner R, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, et al. Tbr1 regulates differentiation of the preplate and layer 6. Neuron. 2001;29:353-66 pubmed..These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development. ..
- Stoykova A, Gotz M, Gruss P, Price J. Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain. Development. 1997;124:3765-77 pubmed..These data suggest a link between the transcription factor, Pax6, R-cadherin expression, cellular adhesion and boundary formation between developing forebrain regions. ..
- Montelius A, Marmigere F, Baudet C, Aquino J, Enerback S, Ernfors P. Emergence of the sensory nervous system as defined by Foxs1 expression. Differentiation. 2007;75:404-17 pubmed..These data define a sequential emergence of neuronal precursors of the sensory nervous system with different molecular characteristics, starting during migration and continuing well after DRG condensation. ..
- Farkas L, Haffner C, Giger T, Khaitovich P, Nowick K, Birchmeier C, et al. Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex. Neuron. 2008;60:40-55 pubmed publisher..Our data imply that Insm1 is involved in the generation and expansion of basal progenitors, a hallmark of neocortex evolution. ..
- Baas D, Bumsted K, Martinez J, Vaccarino F, Wikler K, Barnstable C. The subcellular localization of Otx2 is cell-type specific and developmentally regulated in the mouse retina. Brain Res Mol Brain Res. 2000;78:26-37 pubmed....
- Hendershot T, Liu H, Clouthier D, Shepherd I, Coppola E, Studer M, et al. Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons. Dev Biol. 2008;319:179-91 pubmed publisher..Hand2 has a pivotal function in a non-linear cross-regulatory network of DNA binding proteins that affect cell autonomous control of differentiation and cell type-specific gene expression. ..
- Agarwala S, Ragsdale C. A role for midbrain arcs in nucleogenesis. Development. 2002;129:5779-88 pubmed..Taken together, these findings suggest that arcs represent a patterning mechanism by which midbrain progenitor cells are allocated to specific nuclear fates. ..
- Julian E, Dave R, Robson J, Hallahan A, Wainwright B. Canonical Notch signaling is not required for the growth of Hedgehog pathway-induced medulloblastoma. Oncogene. 2010;29:3465-76 pubmed publisher..Hedgehog-dependent medulloblastoma were not blocked by loss of RBP-J, indicating that canonical Notch signaling is not required for tumor initiation and growth in this model. ..
- Schwarting G, Henion T, Nugent J, Caplan B, Tobet S. Stromal cell-derived factor-1 (chemokine C-X-C motif ligand 12) and chemokine C-X-C motif receptor 4 are required for migration of gonadotropin-releasing hormone neurons to the forebrain. J Neurosci. 2006;26:6834-40 pubmed..The MM is smaller in CXCR4-/- mice, suggesting that some MM cells also require SDF-1/CXCR4 function for migration and survival. ..
- Politis P, Rohrer H, Matsas R. Expression pattern of BM88 in the developing nervous system of the chick and mouse embryo. Gene Expr Patterns. 2007;7:165-77 pubmed..BM88 is also widely expressed in the mouse embryonic CNS and PNS, in both nestin-positive neuroepithelial cells and post-mitotic betaIII-tubulin positive neurons. ..
- Tischfield M, Baris H, Wu C, Rudolph G, Van Maldergem L, He W, et al. Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell. 2010;140:74-87 pubmed publisherWe report that eight heterozygous missense mutations in TUBB3, encoding the neuron-specific beta-tubulin isotype III, result in a spectrum of human nervous system disorders that we now call the TUBB3 syndromes...
- Prince J, Cho J, Dumontier E, Andrews W, Cutforth T, Tessier Lavigne M, et al. Robo-2 controls the segregation of a portion of basal vomeronasal sensory neuron axons to the posterior region of the accessory olfactory bulb. J Neurosci. 2009;29:14211-22 pubmed publisher..Together, these results identify Robo-2 as a receptor that controls the targeting of basal VSN axons to the posterior AOB. ..
- Murga M, Bunting S, Montaña M, Soria R, Mulero F, Canamero M, et al. A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet. 2009;41:891-8 pubmed publisher....
- Woodhoo A, Alonso M, Droggiti A, Turmaine M, D Antonio M, Parkinson D, et al. Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci. 2009;12:839-47 pubmed publisher..These findings are relevant for understanding the molecular mechanisms that control Schwann cell plasticity and underlie nerve pathology, including demyelinating neuropathies and tumorigenesis. ..
- Meng H, Lee V. Differential expression of sphingosine-1-phosphate receptors 1-5 in the developing nervous system. Dev Dyn. 2009;238:487-500 pubmed publisher..On the contrary, S1pr3 was predominantly detected in non-neuronal cells within and surrounding neural structures. We also described novel expression sites for S1P receptors in the developing nervous system. ..
- Kwiatkowski A, Rubinson D, Dent E, Edward van Veen J, Leslie J, Zhang J, et al. Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron. 2007;56:441-55 pubmed..These findings provide insight into the regulation of neurite formation and the role of the actin cytoskeleton during cortical development. ..
- Lien W, Klezovitch O, Fernandez T, Delrow J, Vasioukhin V. alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science. 2006;311:1609-12 pubmed..We propose that alphaE-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and that this connection may provide a negative feedback loop controlling the size of developing cerebral cortex. ..
- Matsumoto S, Banine F, Struve J, Xing R, Adams C, Liu Y, et al. Brg1 is required for murine neural stem cell maintenance and gliogenesis. Dev Biol. 2006;289:372-83 pubmed....
- Gambello M, Darling D, Yingling J, Tanaka T, Gleeson J, Wynshaw Boris A. Multiple dose-dependent effects of Lis1 on cerebral cortical development. J Neurosci. 2003;23:1719-29 pubmed..These studies reveal the importance of LIS1 levels in orderly cerebral cortical morphogenesis and suggest new insights into the pathogenesis of type I lissencephaly. ..
- Britsch S, Goerich D, Riethmacher D, Peirano R, Rossner M, Nave K, et al. The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev. 2001;15:66-78 pubmed..Haploinsufficiency of Sox10 can thus cause pigmentation and megacolon defects, which are also observed in Sox10(Dom)/+ mice and in patients with Waardenburg-Hirschsprung disease caused by heterozygous SOX10 mutations. ..
- Gleeson J, Lin P, Flanagan L, Walsh C. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron. 1999;23:257-71 pubmed..Therefore, DCX likely directs neuronal migration by regulating the organization and stability of microtubules. ..
- Jacob J, Storm R, Castro D, Milton C, Pla P, Guillemot F, et al. Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development. 2009;136:2477-85 pubmed publisher..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations. ..
- Nural H, Todd Farmer W, Mastick G. The Slit receptor Robo1 is predominantly expressed via the Dutt1 alternative promoter in pioneer neurons in the embryonic mouse brain and spinal cord. Gene Expr Patterns. 2007;7:837-45 pubmed..For both probes, the main hybridization signal was limited to two spots in the nuclei of individual cells. This study shows distinct expression patterns for the Dutt1 and Robo1 alternative promoters in the embryonic nervous system. ..
- Talamillo A, Quinn J, Collinson J, Caric D, Price D, West J, et al. Pax6 regulates regional development and neuronal migration in the cerebral cortex. Dev Biol. 2003;255:151-63 pubmed....