Vsx2

Summary

Gene Symbol: Vsx2
Description: visual system homeobox 2
Alias: Chx10, Hox-10, Hox10, visual system homeobox 2, C. elegans ceh-10 homeo domain containing homolog, ceh-10 homeodomain-containing homolog, homeobox protein CHX10, ocular retardation
Species: mouse

Top Publications

  1. ncbi The development of corticocollicular projections in anophthalmic mice
    M Y Khachab
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178 0405, USA
    Brain Res Dev Brain Res 114:179-92. 1999
  2. ncbi Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart
    K Sakamaki
    Graduate School of Biostudies and Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Cell Death Differ 9:1196-206. 2002
  3. ncbi A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool
    Marta G del Barrio
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 134:3427-36. 2007
  4. pmc Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina
    Crystal L Sigulinsky
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Dev Biol 317:560-75. 2008
  5. doi Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium
    Naoko Fujimura
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Dev Biol 334:31-45. 2009
  6. ncbi Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity
    D Jonathan Horsford
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 132:177-87. 2005
  7. pmc Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development
    Zhigang Cai
    Department of Medical and Molecular Genetics, Stark Neuroscience Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci 30:4110-9. 2010
  8. pmc Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina
    Liang Feng
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Development 133:4815-25. 2006
  9. pmc Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice
    Sarah E Ross
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 65:886-98. 2010
  10. ncbi Genetic rescue of cell number in a mouse model of microphthalmia: interactions between Chx10 and G1-phase cell cycle regulators
    Eric S Green
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Development 130:539-52. 2003

Research Grants

Scientific Experts

Detail Information

Publications124 found, 100 shown here

  1. ncbi The development of corticocollicular projections in anophthalmic mice
    M Y Khachab
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178 0405, USA
    Brain Res Dev Brain Res 114:179-92. 1999
    ..Furthermore, cortical axons can terminate in the superior colliculus with a coarse topography when retinal axons are absent, but they cannot form a topographically refined projection...
  2. ncbi Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart
    K Sakamaki
    Graduate School of Biostudies and Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Cell Death Differ 9:1196-206. 2002
    ..5-E11.5, suggesting that these defects are most likely secondary to a lack of physiological caspase-8 activity. Taken together, these results suggest that caspase-8 is indispensable for embryonic development...
  3. ncbi A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool
    Marta G del Barrio
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 134:3427-36. 2007
    ....
  4. pmc Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina
    Crystal L Sigulinsky
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Dev Biol 317:560-75. 2008
    ..To do this, we examined Shh expression and Hh signaling activity in the homozygous ocular retardation J (orJ) mouse, which harbors a recessive null allele in the Vsx2 gene...
  5. doi Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium
    Naoko Fujimura
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Dev Biol 334:31-45. 2009
    ..documented by downregulation of RPE-specific markers Mitf and Otx2 and ectopic expression of NR-specific markers Chx10 and Rx, respectively...
  6. ncbi Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity
    D Jonathan Horsford
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 132:177-87. 2005
    ..the cells of the optic vesicle (OV) become either neuroretinal progenitors expressing the transcription factor Chx10, or retinal pigment epithelium (RPE) progenitors expressing the transcription factor Mitf...
  7. pmc Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development
    Zhigang Cai
    Department of Medical and Molecular Genetics, Stark Neuroscience Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci 30:4110-9. 2010
    ..Together, these results demonstrate that Shp2 mediates FGF-Ras signaling to control retinal progenitor cell fate...
  8. pmc Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina
    Liang Feng
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Development 133:4815-25. 2006
    ..Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes...
  9. pmc Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice
    Sarah E Ross
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 65:886-98. 2010
    ..Our findings suggest that Bhlhb5 is required for the survival of a specific population of inhibitory interneurons that regulate pruritus, and provide evidence that the loss of inhibitory synaptic input results in abnormal itch...
  10. ncbi Genetic rescue of cell number in a mouse model of microphthalmia: interactions between Chx10 and G1-phase cell cycle regulators
    Eric S Green
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Development 130:539-52. 2003
    Insufficient cell number is a primary cause of failed retinal development in the Chx10 mutant mouse. To determine if Chx10 regulates cell number by antagonizing p27(Kip1) activity, we generated Chx10, p27(Kip1) double null mice...
  11. pmc Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina
    Izzy Livne-Bar
    Toronto Western Research Institute, University Health Network
    Proc Natl Acad Sci U S A 103:4988-93. 2006
    In the Chx10-null ocular retardation (or(J)) mouse, retinal progenitor cell (RPC) proliferation is impaired, and bipolar neurons, a late born cell type, fail to differentiate...
  12. ncbi Roles of homeobox and bHLH genes in specification of a retinal cell type
    J Hatakeyama
    Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Development 128:1313-22. 2001
    Previous analysis of mutant mice has revealed that the bHLH genes Mash1 and Math3, and the homeobox gene Chx10 are essential for generation of bipolar cells, the interneurons present in the inner nuclear layer of the retina...
  13. ncbi Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter
    Sheldon Rowan
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 271:388-402. 2004
    b>Chx10 is a homeobox-containing transcription factor critical for progenitor cell proliferation and bipolar cell determination in the developing retina...
  14. ncbi Notch 1 inhibits photoreceptor production in the developing mammalian retina
    Ashutosh P Jadhav
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 133:913-23. 2006
    ..These cone enriched mutant mice should prove to be a valuable resource for the study of this relatively rare mammalian photoreceptor cell type...
  15. doi Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome
    Chantal F Medina
    Regenerative Medicine, Ottawa Health Research Institute, Ottawa, Ontario, Canada K1H 8L6
    Hum Mol Genet 18:966-77. 2009
    ..These results implicate a role for Atrx in interneuron survival and differentiation...
  16. ncbi Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer
    I S Liu
    Department of Genetics, Hospital for Sick Children, Toronto, Ontario, Canada
    Neuron 13:377-93. 1994
    ..We describe a 39 kDa murine polypeptide (Chx10) with a homeodomain 82% identical to that of the nematode protein ceh-10...
  17. ncbi Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation
    M Burmeister
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720, USA
    Nat Genet 12:376-84. 1996
    b>Ocular retardation (or) is a murine eye mutation causing microphthalmia, a thin hypocellular retina and optic nerve aplasia...
  18. ncbi Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
    J Ericson
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 90:169-80. 1997
    ..2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain...
  19. ncbi PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development
    J D Burrill
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Development 124:4493-503. 1997
    ..These results demonstrate that the early activity of patterning genes in the ventricular zone determines interneuron identity in the spinal cord...
  20. ncbi Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    M P Matise
    Developmental Genetics Program and Howard Hughes Medical Institute, and Department of Cell Biology and Physiology and Neuroscience, NYU Medical Center, New York, NY 10016, USA
    Development 125:2759-70. 1998
    ....
  21. pmc A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice
    C Ma
    Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:9938-43. 1998
    ..We also tested whether expression of a bcl-2 transgene could prevent the death and found that it could not...
  22. ncbi Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
    S Arber
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Neuron 23:659-74. 1999
    ..These findings show that HB9 has an essential function in consolidating the identity of postmitotic MNs...
  23. ncbi Partial rescue of the ocular retardation phenotype by genetic modifiers
    C Bone-Larson
    Department of Anatomy and Neurobiology, Medical College of Ohio, 3035 Arlington Avenue, Toledo, Ohio 43614 5804, USA
    J Neurobiol 42:232-47. 2000
    The or(J) allele of the murine ocular retardation mutation is caused by a premature stop codon in the homeodomain of the Chx10 gene...
  24. ncbi Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF
    M Nguyen
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Development 127:3581-91. 2000
    ..results in the maintenance of MITF in the distal optic epithelium, lack of expression of the neuroretinal-specific CHX10 transcription factor, and conversion of this epithelium into a pigmented monolayer...
  25. pmc Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    R Ashery-Padan
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Goettingen D 37077, Germany
    Genes Dev 14:2701-11. 2000
    ....
  26. ncbi Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord
    R Scardigli
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, B P 163, 67404 Illkirch Cedex, C U, de Strasbourg, France
    Neuron 31:203-17. 2001
    ..Thus, neuronal differentiation involves crossregulatory interactions between a bHLH-driven program of neurogenesis and genetic pathways specifying progenitor and neuronal identity in the spinal cord...
  27. ncbi The cyclin-dependent kinase inhibitors p19(Ink4d) and p27(Kip1) are coexpressed in select retinal cells and act cooperatively to control cell cycle exit
    Justine J Cunningham
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Mol Cell Neurosci 19:359-74. 2002
    ..These data indicate that select retinal cells express both p19(Ink4d) and p27(Kip1) and that they act cooperatively to ensure cell cycle exit...
  28. ncbi Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    Q Richard Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 109:75-86. 2002
    ..Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons...
  29. ncbi Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord
    Michael K Gross
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 34:535-49. 2002
    ..Lbx1, therefore, plays a critical role in the development of sensory pathways in the spinal cord that relay pain and touch...
  30. ncbi Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina
    Jimmy de Melo
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9, Canada
    J Comp Neurol 461:187-204. 2003
    ..1999] J. Comp. Neurol. 217-237). At E13.5, the expression of four homeodomain proteins, DLX2, BRN3b, PAX6, and CHX10, define distinct yet overlapping domains in the retinal neuroepithelium...
  31. ncbi Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6
    Nicole Baumer
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Development 130:2903-15. 2003
    ..Together, these results demonstrate that the redundant activities of Pax2 and Pax6 direct the determination of RPE, potentially by directly controlling the expression of RPE determinants...
  32. ncbi Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton
    Deneen M Wellik
    Howard Hughes Medical Institute and University of Utah, Salt Lake City, UT 84112, USA
    Science 301:363-7. 2003
    Mice in which all members of the Hox10 or Hox11 paralogous group are disrupted provide evidence that these Hox genes are involved in global patterning of the axial and appendicular skeleton...
  33. ncbi Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development
    Akihiro Nishida
    Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Nat Neurosci 6:1255-63. 2003
    ..Thus, Otx2 is a key regulatory gene for the cell fate determination of retinal photoreceptor cells. Our results reveal the key molecular steps required for photoreceptor cell-fate determination and pinealocyte development...
  34. ncbi All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004
    ..Therefore, in the spinal cord all Hh signaling is Gli dependent. Furthermore, a combination of Gli2 and Gli3 is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors...
  35. ncbi Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors
    Shengguo Li
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854 USA
    Neuron 43:795-807. 2004
    ..Our data suggest a model in which Foxn4 cooperates with other key retinogenic factors to mediate the multipotent differentiation of retinal progenitors...
  36. ncbi A POU factor binding site upstream of the Chx10 homeobox gene is required for Chx10 expression in subsets of retinal progenitor cells and bipolar cells
    Sheldon Rowan
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Dev Biol 281:240-55. 2005
    ..An analysis of the regulatory region of the retinal homeodomain transcription factor, Chx10, was carried out using in ovo electroporations in chick and transgenic mice...
  37. ncbi CHX10 targets a subset of photoreceptor genes
    Kimberley M Dorval
    Toronto Western Research Institute, University Health Network, Ontario, Canada
    J Biol Chem 281:744-51. 2006
    The homeobox gene CHX10 is required for retinal progenitor cell proliferation early in retinogenesis and subsequently for bipolar neuron differentiation...
  38. pmc Absence of chx10 causes neural progenitors to persist in the adult retina
    Nathalie S Dhomen
    Developmental Biology Unit, Institute of Child Health, London, UK
    Invest Ophthalmol Vis Sci 47:386-96. 2006
    ..This study used Chx10-/- (ocular retardation) mice to investigate how lack of Chx10 affects progenitor/stem cell behavior in the retina and ciliary ..
  39. ncbi Math5 is required for both early retinal neuron differentiation and cell cycle progression
    Tien T Le
    Division of Developmental Biology, Children s Hospital Research Foundation, Departments of Pediatrics and Ophthalmology University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 7007, USA
    Dev Biol 295:764-78. 2006
    ..Thus, Math5 orchestrates neurogenesis in multiple ways, regulating both intrinsic and extrinsic processes...
  40. ncbi Mapping of genetic modifiers affecting the eye phenotype of ocular retardation (Chx10or-J) mice
    Gilbert Wong
    Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Mamm Genome 17:518-25. 2006
    b>Ocular retardation is a recessive murine mutation whose phenotypic expression is greatly affected by genetic background effects...
  41. ncbi Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH
    Julian Morcillo
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 133:3179-90. 2006
    ..Furthermore, SHH addition re-establishes Pax2 expression in late optic cups derived from ocular retardation (or) embryos, where optic disc development is impaired owing to the near absence of SHH-producing RGC...
  42. pmc Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development
    Xueyao Fu
    Department of Biochemistry and Molecular Biology, Unit 1000, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Dev Biol 299:424-37. 2006
    ..The results further imply that retinal lamination and retinal cell differentiation are genetically separable processes...
  43. ncbi Selective expression of Bhlhb5 in subsets of early-born interneurons and late-born association neurons in the spinal cord
    Ben Liu
    The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Dev Dyn 236:829-35. 2007
    ..At late stages of development, Bhlhb5 expression is detected in a subset of late-born dorsal association interneurons that migrate into the uppermost layer of the dorsal horn...
  44. pmc Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina
    Anna M Clark
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA
    Brain Res 1192:99-113. 2008
    b>Chx10/Vsx2 and Vsx1 are the only Paired-like CVC (Prd-L:CVC) homeobox genes in the mouse genome. Both are expressed in the retina and have important but distinct roles in retinal development...
  45. ncbi Lim1 is essential for the correct laminar positioning of retinal horizontal cells
    Ross A Poche
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:14099-107. 2007
    ..This study is the first to describe a cell type-specific genetic program that is essential for targeting a discrete retinal neuron population to the proper lamina...
  46. pmc N-myc coordinates retinal growth with eye size during mouse development
    Rodrigo A P Martins
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Genes Dev 22:179-93. 2008
    ..We propose that N-myc lies upstream of the cell cycle machinery in the developing mouse retina and thus coordinates the growth of both the retina and eye through extrinsic cues...
  47. pmc Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF
    Kapil Bharti
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:1169-78. 2008
    ..Moreover, in mutants of the retinal Mitf regulator Chx10 (Vsx2), reduced cell proliferation and abnormal pigmentation of the retina are associated with a preferential ..
  48. pmc Investigation of Frizzled-5 during embryonic neural development in mouse
    Carole J Burns
    Department of Neurobiology and Anatomy, John A Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA
    Dev Dyn 237:1614-26. 2008
    ..Thus, the function of Fzd5 during eye development appears to be species-dependent...
  49. pmc Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance
    Martine Manuel
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 8:59. 2008
    ..Here, we examined the consequences of over-expression for the eye and its axonal connections...
  50. pmc LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons
    Kaumudi Joshi
    Department of Molecular Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 61:839-51. 2009
    ..Thus, LMO4 plays essential roles in directing a balanced generation of inhibitory and excitatory neurons in the ventral spinal cord...
  51. pmc BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons
    Qian Ding
    University of Rochester Eye Institute, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 29:3992-4003. 2009
    ..Thus, BARHL2 appears to have numerous roles in retinal development, including regulating neuronal subtype specification, differentiation, and survival...
  52. pmc Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells
    Gaurav Das
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Neural Dev 4:15. 2009
    ..How cyclin D1 influences RPC behavior, especially during the embryonic period, is unclear...
  53. pmc Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression
    Peter Westenskow
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Development 136:2505-10. 2009
    ....
  54. pmc Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis
    April N Smith
    Division of Pediatric Ophthalmology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 136:2977-85. 2009
    ..These data support a model in which the mode of Pax6-Sox2 inter-regulation is stage-dependent and suggest an underlying mechanism in which DNA binding site availability is regulated...
  55. pmc Subtype specification of GABAergic amacrine cells by the orphan nuclear receptor Nr4a2/Nurr1
    Haisong Jiang
    Center for Advanced Biotechnology and Medicine, Department of Pediatrics, and Graduate Program in Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Neurosci 29:10449-59. 2009
    ....
  56. pmc The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina
    Sacha Reichman
    Department of Genetics, Institut de la Vision, INSERM Université Pierre et Marie Curie Paris 6, UMR S 968, Paris, France
    Hum Mol Genet 19:250-61. 2010
    ..transcription factors, chosen based upon their expression pattern, we identified the homeodomain proteins CHX10/VSX2, VSX1 and PAX4, as well as the zinc finger protein SP3, as factors that can stimulate both the mouse and ..
  57. pmc COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis
    Ke Tang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Development 137:725-34. 2010
    ..Taken together, our findings reveal novel and distinct cell-intrinsic mechanisms mediated by COUP-TF genes to direct the specification and differentiation of progenitor cells, and that COUP-TFs are crucial for dorsalization of the eye...
  58. pmc Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors
    Kangxin Jin
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 30:11902-16. 2010
    ....
  59. pmc The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance
    Andreas Holz
    Cell and Molecular Biology, University of Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany
    Development 137:4249-60. 2010
    ..As both factors affect floor plate development, control of commissural axon trajectories might be the underlying mechanism...
  60. pmc Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6
    Danielle Matsushima
    UNC Neuroscience Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Development 138:443-54. 2011
    ..Collectively, these results demonstrate that precise regulation of the ratio of SOX2 to PAX6 is necessary to ensure accurate progenitor cell specification, and place SOX2 as a decisive factor of neural competence in the retina...
  61. pmc A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development
    Kapil Bharti
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002757. 2012
    ..by inhibiting canonical WNT signaling and stimulating the expression of retinogenic genes, including Six6 and Vsx2. Our results demonstrate that in conjunction with Mitf/Tfec Pax6 acts as an anti-retinogenic factor, whereas in ..
  62. pmc Foxg1 is required to limit the formation of ciliary margin tissue and Wnt/β-catenin signalling in the developing nasal retina of the mouse
    Vassiliki Fotaki
    University of Edinburgh, Centre for Integrative Physiology, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Dev Biol 380:299-313. 2013
    ..Our results reveal a new role of Foxg1 in limiting CM development in the nasal peripheral retina and add a new molecular player in the developmental network involved in CM specification...
  63. pmc A trans-acting protein effect causes severe eye malformation in the Mp mouse
    Joe Rainger
    The MRC Human Genetics Unit, MRC Institute of Genetic and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    PLoS Genet 9:e1003998. 2013
    ..The prediction of similar trans-acting protein effects will be an important challenge in the medical interpretation of human mutations from whole exome sequencing...
  64. pmc PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF
    Shaul Raviv
    Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS Genet 10:e1004360. 2014
    ..This study exemplifies how one kernel gene pivotal in organ formation accomplishes a lineage-specific role during terminal differentiation of a single lineage...
  65. ncbi Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1
    A Pierani
    Howard Hughes Medical Institute, Department of Biochemistry and, Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 29:367-84. 2001
    ..Thus, a single progenitor homeodomain transcription factor coordinates many of the differentiated properties of one class of interneurons generated in the ventral spinal cord...
  66. ncbi Evx1 is a postmitotic determinant of v0 interneuron identity in the spinal cord
    L Moran-Rivard
    Biology Graduate Program University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093, USA
    Neuron 29:385-99. 2001
    ..Our findings demonstrate that Evx1 is a postmitotic determinant of V0 interneuron identity and reveal a critical postmitotic phase for neuronal determination in the developing spinal cord...
  67. ncbi Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retina
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology and Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 15:525-30. 2005
    ..Intrinsic rather than extrinsic factors are likely to play the critical roles in determining retinal cell fate...
  68. ncbi Distinct patterns of expression of the RB gene family in mouse and human retina
    Clarellen Spencer
    The Division of Cancer Informatics, Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Canada
    Gene Expr Patterns 5:687-94. 2005
    ..The RB gene family is dynamically and variably expressed through retinal development in specific retinal cells...
  69. pmc Multiple requirements for Hes 1 during early eye formation
    Hae Young Lee
    Department of Pediatrics, Northwestern University Medical School at Children s Memorial Institute for Education and Research, Chicago, IL 60614, USA
    Dev Biol 284:464-78. 2005
    ..Together, these studies demonstrate that Hes1, like Pax6, simultaneously regulates multiple developmental processes during optic development...
  70. pmc Compensation by tumor suppressor genes during retinal development in mice and humans
    Stacy L Donovan
    Department of Developmental Neurobiology, St, Jude Children s Research Hospital, Memphis, TN 38105, USA
    BMC Biol 4:14. 2006
    ..In this manuscript, we explore the different roles of the Rb family in human and mouse retinal development in order to better understand the species-specific difference in retinoblastoma susceptibility...
  71. pmc Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina
    Yasser Elshatory
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    J Comp Neurol 503:182-97. 2007
    ..As bipolar cell development proceeds from P5-10 the colocalization of Isl1 and the pan-bipolar cell marker Chx10 reveals the organization of ON-center bipolar cell nuclei to the upper portion of the inner nuclear layer...
  72. pmc Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis
    Angelo Iulianella
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA
    Development 135:729-41. 2008
    ..Thus our work defines novel roles for Cux2 as a transcription factor that integrates cell-cycle progression with neural progenitor development during spinal cord neurogenesis...
  73. doi Characterization of Foxp2-expressing cells in the developing spinal cord
    Y Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1, Kimiidera, Wakayama 641 8509, Japan
    Neuroscience 162:1150-62. 2009
    ..with some homeodomain transcription factors revealed that Foxp2-expressing neurons were Pax2(+), En1(+), Evx1(-), Chx10(-), Gata3(-), and Lhx3(-) V1 interneurons in the intermediate zone throughout the ventral spinal cord, indicating ..
  74. pmc Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity
    Mi Ryoung Song
    Bioimaging Research Center and Cell Dynamics Research Center, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
    Development 136:2923-32. 2009
    ....
  75. pmc Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina
    Lin Ma
    IMCH, HBI, University of Calgary, T2N 4N1, Canada
    Neural Dev 2:11. 2007
    ..Here we report a similar role for two tumor suppressor genes, the Zac1 zinc finger transcription factor and that encoding the cytokine TGFbetaII, in the developing retina...
  76. pmc Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6
    Erin N Star
    Department of Biology, University of Victoria, Victoria, BC V8W 3N5, Canada
    Development 139:4644-55. 2012
    ..This work provides insight into the generation of neuronal subtypes by revealing a mechanism in which opposing, yet interdependent, transcription factors regulate subtype identity...
  77. ncbi Localization of gene encoding the thyroid stimulating hormone receptor (Tshr) on mouse chromosome 12
    B A Taylor
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Mamm Genome 7:626-8. 1996
  78. ncbi Coexpression of SCL and GATA3 in the V2 interneurons of the developing mouse spinal cord
    Emma Smith
    Institute for Molecular Bioscience, incorporating the Special Research Centre for Functional and Applied Genomics, The University of Queensland, Brisbane, Australia
    Dev Dyn 224:231-7. 2002
    ..These experiments revealed that SCL is expressed in a medially restricted subpopulation of GATA-3 producing cells, suggesting a possible role for this factor in the differentiation of the GATA population of V2 interneurons...
  79. ncbi Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain
    Alexandre Pattyn
    Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Development 130:4149-59. 2003
    ..Thus, both visceral and somatic motoneuron differentiation appear to rely on the combined activity of cell intrinsic determinants, rather than on a single key determinant of neuronal cell fate...
  80. ncbi Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord
    Qiubo Lei
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Development 131:3593-604. 2004
    ..Thus, multiple ventral neuronal types can develop in the absence of Gli function, but require balanced Gli protein activities for their correct patterning and differentiation...
  81. ncbi Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina
    Jimmy de Melo
    Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, R3E 3J7, Canada
    Development 132:311-22. 2005
    ..Herein, we propose a model whereby early-born RGCs are Dlx1 and Dlx2 independent, but Dlx function is necessary for terminal differentiation of late-born RGC progenitors...
  82. ncbi Homeodomain transcription factors in the development of subsets of hindbrain reticulospinal neurons
    Ana C Cepeda-Nieto
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro 76230, Mexico
    Mol Cell Neurosci 28:30-41. 2005
    ..in chick and mouse embryos combined with immunostaining for the homeodomain factors Lhx1/Lhx5, Lhx3/Lhx4, and Chx10 have defined transcriptional codes that label subsets of neurons with different axon projection patterns...
  83. ncbi Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning
    Katrin Götz
    Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, Dusseldorf, Germany
    Dev Dyn 233:623-30. 2005
    ....
  84. pmc Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord
    Shengguo Li
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 102:10688-93. 2005
    ..However, coexpression of both Foxn4 and Mash1 promotes the V2b fate while inhibiting the V2a fate, indicating that Foxn4 cooperates with Mash1 to specify the identity of V2b neurons from bipotential p2 progenitors...
  85. ncbi Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development
    Tomas Alanentalo
    Umeå Centre for Molecular Medicine, UCMM, Umea University, S 901 87 Umea, Sweden
    Gene Expr Patterns 6:162-70. 2006
    ..2 both in the CNS and in the gut. Transient Nkx6.2 expression was also detected in the developing pancreas. However, analysis of Nkx6.2(-/-) mice did not display any obvious aberrations of pancreatic or stomach development...
  86. ncbi V1 spinal neurons regulate the speed of vertebrate locomotor outputs
    Simon Gosgnach
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 440:215-9. 2006
    ....
  87. doi Heparan sulfate deficiency in periocular mesenchyme causes microphthalmia and ciliary body dysgenesis
    Keiichiro Iwao
    Department of Ophthalmology and Visual Science, Kumamoto University, Graduate School of Medical Sciences, 1 1 1, Honjo, 860 8556 Kumamoto City, Japan
    Exp Eye Res 90:81-8. 2010
    ..These findings demonstrate that HS in the periocular mesenchyme plays a critical role in normal ocular morphogenesis, indicating reciprocal interactions between the periocular mesenchyme and the neural ectoderm...
  88. pmc AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis
    Erin A Bassett
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Hum Mol Genet 19:1791-804. 2010
    ..In view of recent data showing that mutations in human TFAP2A result in similar eye defects, the current findings demonstrate that AP-2alpha KO mice provide a valuable model for human ocular disease...
  89. pmc Dicer is required for the transition from early to late progenitor state in the developing mouse retina
    Sean A Georgi
    Neurobiology and Behavior Program, Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 30:4048-61. 2010
    ..We conclude that Dicer is necessary for the developmental change in competence of the retinal progenitor cells...
  90. doi Sox1 is required for the specification of a novel p2-derived interneuron subtype in the mouse ventral spinal cord
    Helen Panayi
    The Cyprus Institute of Neurology and Genetics, 2370 Nicosia
    J Neurosci 30:12274-80. 2010
    ..Our data demonstrate that interneuron diversification in the p2 domain is more complex than previously thought and directly implicate Sox1 in this process...
  91. pmc Loss of LMO4 in the retina leads to reduction of GABAergic amacrine cells and functional deficits
    Philippe M Duquette
    Centre for Stroke Recovery, Neuroscience, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    PLoS ONE 5:e13232. 2010
    ..However, the significance of LMO4 in mammalian eye development and function remained unknown since LMO4 null mice die prior to birth...
  92. pmc Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina
    Nissa J Mollema
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e17494. 2011
    ..Taken together, these studies reveal a novel role for Nr1d1, in conjunction with its cofactor Nr2e3, in regulating transcriptional networks critical for photoreceptor development and function...
  93. pmc Isl1 is required for multiple aspects of motor neuron development
    Xingqun Liang
    Key Laboratory of Arrhythmia, Ministry of Education, East Hospital, Tongji University School of Medicine, Shanghai 200120, China
    Mol Cell Neurosci 47:215-22. 2011
    ..In addition, Isl1 is required for survival of cranial ganglia neurons...
  94. pmc Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS
    Hui Wang
    Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Development 138:3711-21. 2011
    ..Together, our data reveal a Shh-Gli-independent transcriptional input that is required to shape the precise spatial and temporal response to extracellular morphogen signaling information during lineage segregation in the CNS...
  95. ncbi Ocular retardation (or) in the mouse
    R M Robb
    Invest Ophthalmol Vis Sci 17:468-73. 1978
    The ocular retardation (or) mutation in mice has been studied morphologically in serial 1 mu sections...
  96. ncbi [Influence of mutant genes on crystallin synthesis in the forming mouse lens. II. Fidget and ocular retardation genes]
    M I Iakovlev
    Ontogenez 8:115-20. 1977
    ..The synthesis of gamma-crystallins appears to begin at the final stages of lens fiber differentiation...
  97. ncbi Interaction of the pRB-family proteins with factors containing paired-like homeodomains
    O Wiggan
    Department of Pathology, University of Toronto, Ontario, Canada
    Oncogene 16:227-36. 1998
    ..the pRB-family members interact with transcription factors which contain paired-like homeodomains such as MHox, Chx10 and Pax-3...
  98. ncbi CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis
    G Kolle
    Centre for Molecular and Cellular Biology, The University of Queensland, Brisbane, Australia
    Mech Dev 90:181-93. 2000
    ..Our results suggest a role for CRIM1/Crim1 in CNS development possibly via growth factor binding...
  99. pmc Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity
    Madelen Persson
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, S 171 77 Stockholm, Sweden
    Genes Dev 16:2865-78. 2002
    ..Together these data raise the possibility that Gli proteins act as common mediators integrating Shh signals, and other sources of positional information, to control patterning throughout the ventral neural tube...
  100. ncbi Retinal remodeling triggered by photoreceptor degenerations
    Bryan W Jones
    John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132
    J Comp Neurol 464:1-16. 2003
    ..Although remodeling may constrain therapeutic intervals for molecular, cellular, or bionic rescue, it suggests that the neural retina may be more plastic than previously believed...

Research Grants2

  1. Molecular Mechanisms of Aging: 33rd Ann. Mtg. of AGE
    Norman Wolf; Fiscal Year: 2004
    ..Dr. Bickford has investigated hotel accommodations there and has found that both the Radisson and the Hilton offer excellent accommodations for the meeting. She is negotiating with both. ..
  2. DIETARY & GENETIC CONTROL OF ROS DAMAGE TO THE LENS
    Norman S Wolf; Fiscal Year: 2010
    ..These will aid in the search for initiating events and the mechanisms leading up to the cataract formation. ..