weaver

Summary

Gene Symbol: weaver
Description: potassium inwardly-rectifying channel, subfamily J, member 6
Alias: BIR1, GIRK2, KATP2, KCNJ7, Kir3.2, weaver, G protein-activated inward rectifier potassium channel 2, G-protein-coupled inward rectifier K+ channel 2-1, G-protein-coupled inward rectifier K+ channel 2-A, G-protein-coupled inward rectifier K+ channel 2-B, G-protein-coupled inward rectifier K+ channel 2-C, GIRK-2, inward rectifier K(+) channel Kir3.2, potassium channel, inwardly rectifying subfamily J member 6, potassium inwardly-rectifying channel J6
Species: mouse

Top Publications

  1. ncbi Topographic distribution of dopamine uptake, choline uptake, choline acetyltransferase, and GABA uptake in the striata of weaver mutant mice
    J R Simon
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202
    Neurochem Res 17:431-6. 1992
  2. ncbi Dopamine deficiency in the weaver mutant mouse: an animal model of olivopontocerebellar atrophy
    H Chou
    Department of Neurochemistry, Okayama University Medical School, Japan
    Res Commun Chem Pathol Pharmacol 74:117-20. 1991
  3. ncbi Degeneration of Sertoli and spermatogenic cells in homozygous and heterozygous weaver mice
    T Verina
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Neurogenet 9:251-65. 1995
  4. ncbi Ataxia-ameliorating effects of YM-14673, a potent analog of thyrotropin releasing hormone, in ataxic mutant mice
    K Matsui
    National Institute of Neuroscience, NCNP, Tokyo, Japan
    Eur J Pharmacol 254:295-7. 1994
  5. ncbi Molecular cloning of a mouse G-protein-activated K+ channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain
    T Kobayashi
    Department of Neuropathology, Niigata University, Japan
    Biochem Biophys Res Commun 208:1166-73. 1995
  6. ncbi Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cells
    P C Salinas
    Department of Developmental Biology, Stanford University, CA 94305 5428
    Development 120:1277-86. 1994
  7. ncbi Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth
    E Ehler
    Developmental Biology Research Centre, Randall Institute, King s College London, United Kingdom
    Mol Cell Neurosci 9:1-12. 1997
  8. ncbi Complex-1 activity and 18F-DOPA uptake in genetically engineered mouse model of Parkinson's disease and the neuroprotective role of coenzyme Q10
    Sushil K Sharma
    Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, United States
    Brain Res Bull 70:22-32. 2006
  9. ncbi Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels
    F Lesage
    Institut de Pharmacologie Moleculaire et Cellulaire, Sophia Antipolis, Valbonne, France
    J Biol Chem 270:28660-7. 1995
  10. ncbi Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain
    F Lesage
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Valbonne, France
    FEBS Lett 353:37-42. 1994

Research Grants

Scientific Experts

Detail Information

Publications132 found, 100 shown here

  1. ncbi Topographic distribution of dopamine uptake, choline uptake, choline acetyltransferase, and GABA uptake in the striata of weaver mutant mice
    J R Simon
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202
    Neurochem Res 17:431-6. 1992
    ..DA) uptake, choline uptake, choline acetyltransferase (ChAT) activity and GABA uptake within the striata of weaver mutant mice and control mice was determined...
  2. ncbi Dopamine deficiency in the weaver mutant mouse: an animal model of olivopontocerebellar atrophy
    H Chou
    Department of Neurochemistry, Okayama University Medical School, Japan
    Res Commun Chem Pathol Pharmacol 74:117-20. 1991
    The dopamine system in weaver mutant mice, a model of cerebellar atrophy, was studied...
  3. ncbi Degeneration of Sertoli and spermatogenic cells in homozygous and heterozygous weaver mice
    T Verina
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Neurogenet 9:251-65. 1995
    In the neurological mutant mouse weaver (wv/wv), the majority of males are infertile due to hypospermatogenesis. Heterozygous weaver mice (wv/+) cease mating successfully when males reach an average age of 3.5 months...
  4. ncbi Ataxia-ameliorating effects of YM-14673, a potent analog of thyrotropin releasing hormone, in ataxic mutant mice
    K Matsui
    National Institute of Neuroscience, NCNP, Tokyo, Japan
    Eur J Pharmacol 254:295-7. 1994
    ..releasing hormone (TRH), on the behavior of ataxic mutant mice (staggerer, realer, Purkinje cell degeneration and weaver mice) were investigated in comparison with those of TRH in an open-field apparatus...
  5. ncbi Molecular cloning of a mouse G-protein-activated K+ channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain
    T Kobayashi
    Department of Neuropathology, Niigata University, Japan
    Biochem Biophys Res Commun 208:1166-73. 1995
    ....
  6. ncbi Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cells
    P C Salinas
    Department of Developmental Biology, Stanford University, CA 94305 5428
    Development 120:1277-86. 1994
    ..In the weaver mutant, in which granule cells fail to migrate and subsequently die in the external granular layer, Wnt-3 ..
  7. ncbi Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth
    E Ehler
    Developmental Biology Research Centre, Randall Institute, King s College London, United Kingdom
    Mol Cell Neurosci 9:1-12. 1997
    ..function of Tiam-1 in neuronal migration and neurite extension, we examined the pattern of Tiam-1 expression in weaver mice, in which cerebellar granule cells fail to migrate to their final position and subsequently die...
  8. ncbi Complex-1 activity and 18F-DOPA uptake in genetically engineered mouse model of Parkinson's disease and the neuroprotective role of coenzyme Q10
    Sushil K Sharma
    Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, United States
    Brain Res Bull 70:22-32. 2006
    ..in the brains of control-(C57BL/6), metallothionein knock out-, metallothionein transgenic-, and homozygous weaver mutant mice; and human dopaminergic (SK-N-SH) cells with a primary objective to determine the neuroprotective ..
  9. ncbi Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels
    F Lesage
    Institut de Pharmacologie Moleculaire et Cellulaire, Sophia Antipolis, Valbonne, France
    J Biol Chem 270:28660-7. 1995
    ..Krapivinsky, L., and Clapham, D. E. (1995) Nature 374, 135-141). We report the cloning of a mouse GIRK2 splice variant, noted mGIRK2A...
  10. ncbi Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain
    F Lesage
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Valbonne, France
    FEBS Lett 353:37-42. 1994
    ..These results provide the first evidence that the GIRK family, as the IRK family, is composed of multiple genes with members specifically expressed in the nervous system...
  11. pmc Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis
    A Inanobe
    Department of Pharmacology II, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Physiol 521:19-30. 1999
    1. One of the features of weaver mutant mice is male infertility, which suggests that Kir3.2, a G-protein-gated inwardly rectifying K+ channel subunit, may be involved in spermatogenesis. Therefore, we have characterized the Kir3...
  12. ncbi Potassium channels as targets for ethanol: studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas at Austin, Texas 78712 1095, USA
    J Pharmacol Exp Ther 298:521-30. 2001
    ..Selective enhancement of GIRK2 function by intoxicating concentrations of ethanol was recently shown for recombinant homomeric and heteromeric ..
  13. ncbi G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons
    Maria Torrecilla
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 22:4328-34. 2002
    ..We conclude that the acute opioid inhibition of LC neurons is mediated primarily by the activation of G-protein-gated potassium channels and that the cAMP-dependent cation conductance does not contribute significantly to this effect...
  14. pmc A pervasive mechanism for analgesia: activation of GIRK2 channels
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas, Austin 78712, USA
    Proc Natl Acad Sci U S A 100:277-82. 2003
    ..By using GIRK2-null mutant mice, we found marked reduction or complete elimination of the antinociceptive (hot plate test) ..
  15. pmc Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences
    Igor Mitrovic
    Department of Physiology, University of California, San Francisco, 94143, USA
    Proc Natl Acad Sci U S A 100:271-6. 2003
    ..Here, we used mice lacking the GIRK2 channel subunit to assess the relative contribution of these two effector systems to nociceptive processing in ..
  16. ncbi Spinal G-protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia
    Cheryl L Marker
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 24:2806-12. 2004
    ..We detected GIRK1 (G-protein-gated inwardly rectifying K+ channel subunit 1) and GIRK2 subunits, but not GIRK3, in the superficial layers of the dorsal horn...
  17. ncbi Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification
    Scott Pegan
    Structural Biology, The Salk Institute, La Jolla, California 92037, USA
    Nat Neurosci 8:279-87. 2005
    ..1(L) that is important for modulating inward rectification. Taken together, these results suggest the cytoplasmic domains of Kir channels undergo structural changes to modulate gating and inward rectification...
  18. ncbi G-protein-gated potassium (GIRK) channels containing the GIRK2 subunit are control hubs for pharmacologically induced hypothermic responses
    Alberto C S Costa
    Eleanor Roosevelt Institute, University of Denver, Denver, Colorado 80206, USA
    J Neurosci 25:7801-4. 2005
    ..G-protein-gated potassium (GIRK) channels, we investigated the hypothermic response to several of these agents on Girk2 null mutant mice...
  19. doi Behavioral characterization of mice lacking GIRK/Kir3 channel subunits
    M Pravetoni
    Department of Pharmacology, University of Minnesota, Minneapolis, MN, USA
    Genes Brain Behav 7:523-31. 2008
    ..GIRK1(-/-) mice and GIRK2(-/-) mice, however, showed elevated motor activity and delayed habituation to an open field...
  20. pmc Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits
    Shai Berlin
    Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 286:33223-35. 2011
    ..Our findings support the notion that Gα(i/o) actively regulates GIRK. Although regulation of I(basal) is a function of Gα(i)(GDP), our new findings indicate that regulation of kinetics of I(evoked) is mediated by Gα(i)(GTP)...
  21. pmc Conformational changes underlying pore dilation in the cytoplasmic domain of mammalian inward rectifier K+ channels
    Atsushi Inanobe
    Department of Pharmacology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan Center for Advanced Medical Engineering and Informatics, Osaka University, Suita, Osaka, Japan
    PLoS ONE 8:e79844. 2013
    ..These results suggest that the G protein association triggers pore dilation at the cytoplasmic domain in functional channels, and the pore-constituting structural elements contribute differently to these conformational changes. ..
  22. ncbi Comparison of alterations in tyrosine hydroxylase, dopamine levels, and dopamine uptake in the striatum of the weaver mutant mouse
    J A Richter
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202
    Neurochem Res 17:437-41. 1992
    ..DA) system measured in the striatum, dopamine uptake seems to be more severely affected than the others in the weaver mutant mouse...
  23. pmc Cerebellar alterations in the weaver mouse
    A Hirano
    J Cell Biol 56:478-86. 1973
    The fine structure of the cerebellum of weaver mouse was examined and the paucity of granule cells and their axons, the parallel fibers, was confirmed...
  24. ncbi Tune into the weaver channel
    D Goldowitz
    Nat Genet 11:107-9. 1995
  25. ncbi Amelioration of the behavioral phenotype in weaver mutant mice through bilateral intrastriatal grafting of fetal dopamine cells
    L C Triarhou
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Exp Brain Res 104:191-8. 1995
    b>Weaver mutant mice lose more than two-thirds of their nigral dopamine neurons. Behaviorally, weaver homozygotes display tremor, gait instability, and toppling over to the sides after a few steps...
  26. ncbi Alterations in dopamine and serotonin uptake systems in the striatum of the weaver mutant mouse
    E H Stotz
    Department of Psychiatry Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis
    J Neural Transm Gen Sect 97:51-64. 1994
    In the striatum of the homozygous weaver mutant mouse (wv/wv), dopamine content, uptake and tyrosine hydroxylase activity are decreased compared to wild-type (+/+) mice...
  27. ncbi Neurological dysfunction expressed in the grooming behavior of developing weaver mutant mice
    E M Coscia
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada
    Behav Genet 23:533-41. 1993
    The present study provides the first quantitative developmental analysis of movement in the weaver (wv/wv) mutant mouse...
  28. ncbi High-resolution mapping of D16led-1, Gart, Gas-4, Cbr, Pcp-4, and Erg on distal mouse chromosome 16
    A E Mjaatvedt
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Genomics 17:382-6. 1993
    ..these represented genes that mapped within the Sod-1 to Ets-2 interval, which was shown previously to contain the weaver (wv) gene...
  29. ncbi Separation of activation and pattern in grooming development of weaver mice
    V J Bolivar
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada
    Behav Brain Res 75:49-58. 1996
    The effects of environmental conditions and age on grooming behavior were examined in weaver mutant mice and control littermates...
  30. ncbi Expression pattern of integrin beta 1 subunit in Purkinje cells of rat and cerebellar mutant mice
    S Murase
    Department of Anatomy, School of Medicine, Keio University, Tokyo, Japan
    J Comp Neurol 375:225-37. 1996
    ..In both reeler and weaver mice, the INT beta 1-positive parasagittal bands were observed, however, the Purkinje cells in the staggerer mice ..
  31. ncbi Failed cell migration and death of purkinje cells and deep nuclear neurons in the weaver cerebellum
    S M Maricich
    Alzheimer Research Laboratory, Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 17:3675-83. 1997
    The mouse neurological mutant weaver has an atrophic cerebellar cortex with deficits in both Purkinje and granule cell number...
  32. pmc Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice
    P A Slesinger
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143 0724, USA
    Proc Natl Acad Sci U S A 94:12210-7. 1997
    ..in a Girk2 null mutant mouse lacking GIRK2 channels but showing normal cerebellar development as well as in the weaver mouse, which has mutated GIRK2 channels and shows abnormal development...
  33. ncbi Cell death during development of testis and cerebellum in the mutant mouse weaver
    S M Harrison
    Department of Anatomy and Cell Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Dev Biol 195:174-86. 1998
    The murine mutation weaver confers early death during development on cells in testes, cerebellum, and midbrain...
  34. ncbi Ion channel mutations in mouse models of inherited neurological disease
    M H Meisler
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
    Ann Med 29:569-74. 1997
    ..identified by positional cloning of the spontaneous mouse mutants motor endplate disease, tottering, lethargic and weaver. The phenotypes of four allelic mutations identified in the sodium channel gene Scn8a range from ataxia and muscle ..
  35. ncbi Regionalization defects in the weaver mouse cerebellum
    L M Eisenman
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 6799, USA
    J Comp Neurol 394:431-44. 1998
    ..Zebrin II expression has been examined in the weaver (wv) mouse cerebellum...
  36. pmc Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons
    B Liss
    Institute for Neural Signal Transduction, Centre for Molecular Neurobiology, Martinistrasse 52, 20246 Hamburg, Germany
    EMBO J 18:833-46. 1999
    ..In contrast to wild-type, surviving dopaminergic SN neurons of homozygous weaver mouse exclusively expressed SUR1 + Kir6.2 during the active period of dopaminergic neurodegeneration...
  37. pmc A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum
    A Migheli
    Department of Neuroscience, Laboratory of Neuropathology, University of Turin, Italy
    Am J Pathol 155:365-73. 1999
    ..external germinal layer (EGL) of the cerebellum and a nonapoptotic death of midbrain dopaminergic neurons in the weaver (wv) mouse...
  38. ncbi The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels
    B Liss
    Medical Research Council, Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University and Institute for Neural Signaltransduction, Center for Molecular Neurobiology 20246, Hamburg, Germany
    J Neurosci 19:8839-48. 1999
    The phenotype of substantia nigra (SN) neurons in homozygous weaver (wv/wv) mice was studied by combining patch-clamp and single-cell RT-multiplex PCR techniques in midbrain slices of 14-d-old mice...
  39. ncbi The weaver gene has no effect on the generation patterns of mesencephalic dopaminergic neurons
    J Marti
    Department of Biology, Indiana Purdue University, Indianapolis, IN 46202, USA
    Brain Res Dev Brain Res 122:165-72. 2000
    To determine if the weaver gene has action on late-generated neurons in midbrain areas on postnatal day (P) 8 [(3)H] thymidine autoradiography and tyrosine hydroxylase immunohistochemistry were combined in the same tissue section in ..
  40. ncbi Regional differences in the Purkinje cells settled pattern: a comparative autoradiographic study in control and homozygous weaver mice
    Joaquin Marti
    Departament de Biologia Cellular, de Fisiologia i d Immunologia, Universitat Autonoma de Barcelona, Bellaterra, 08193, Spain
    Exp Neurol 175:168-81. 2002
    To determine whether Purkinje cells located in the vermis and the lateral hemispheres of weaver mice homozygotes are distributed according to precise neurogenetic gradients, [3H]thymidine autoradiography was applied on sections of ..
  41. ncbi Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra
    Diane E Smith
    Department of Cell Biology and Anatomy, LSU Medical School New Orleans, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    J Neurocytol 32:293-303. 2003
    GABA-like immunoreactivity (GABA-LI) in the substantia nigra pars compacta (SNc) of mutant weaver mice was investigated at the electron microscope level...
  42. ncbi Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death
    Timothy A Bolger
    Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 25:9544-53. 2005
    ..Finally, an increase of nuclear HDAC4 in granule neurons is also observed in weaver mice, which harbor a mutation that promotes CGN apoptosis...
  43. ncbi RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area
    Gwenael Labouèbe
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, 1, Michel Servet, CH 1211 Geneva, Switzerland
    Nat Neurosci 10:1559-68. 2007
    ..we show that, in DA neurons of mice, the low coupling efficiency reflects the selective expression of heteromeric GIRK2/3 channels and is dynamically modulated by a member of the regulator of G protein signaling (RGS) protein family...
  44. pmc Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling
    Keqiang Xie
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
    Nat Neurosci 13:661-3. 2010
    ..Our findings identify a compartmentalization mechanism that is critical for ensuring high temporal resolution of neuronal G protein signaling...
  45. doi GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area
    Stefanie Reyes
    Neuroscience Research Australia and the School of Medical Sciences, University of New South Wales, Randwick, Sydney, 2031 New South Wales, Australia
    J Comp Neurol 520:2591-607. 2012
    G-protein-regulated inward-rectifier potassium channel 2 (GIRK2) is reported to be expressed only within certain dopamine neurons of the substantia nigra (SN), although very limited data are available in humans...
  46. doi Conductance properties of the inwardly rectifying channel, Kir3.2: molecular and Brownian dynamics study
    Tamsyn A Hilder
    Computational Biophysics Group, Research School of Biology, Australian National University, Canberra, ACT 0200, Australia
    Biochim Biophys Acta 1828:471-8. 2013
    ..The depth of the potential of mean force encountered by tertiapin is -16.1kT, thus indicating that the channel will be half-blocked by 0.4μM of the toxin...
  47. pmc Suprachiasmatic nucleus function and circadian entrainment are modulated by G protein-coupled inwardly rectifying (GIRK) channels
    L M Hablitz
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA
    J Physiol 592:5079-92. 2014
    ..We show that GIRK current and GIRK2 protein expression are greater during the day...
  48. ncbi The tyrosine kinase inhibitor genistein increases endogenous dopamine release from normal and weaver mutant mouse striatal slices
    D J Bare
    Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
    J Neurochem 65:2096-104. 1995
    ..We have previously described alterations in basal and evoked DA release from the striatum of the weaver (wv/wv) mutant mouse, and genotypic differences in fractional release were also observed with genistein ..
  49. ncbi Assessment of a mutation in the H5 domain of Girk2 as a candidate for the weaver mutation
    A E Mjaatvedt
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genome Res 5:453-63. 1995
    ..We demonstrate tight linkage of the Girk2 mutation to the wv phenotype and refine the localization of the weaver (wv) gene on recombinational and physical maps...
  50. ncbi TRAIL-related death receptors in normal, Lurcher and weaver mutant mouse brain
    Jörg Bäurle
    Department of Physiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Arnimallee 22, D 14195 Berlin, Germany
    Neurosci Lett 372:46-51. 2004
    ..Mouse mutants, in particular weaver and Lurcher with their well defined spatio-temporal patterns of neurodegeneration in the cerebellum, the inferior ..
  51. pmc Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease
    Manuchair Ebadi
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Brain Res Mol Brain Res 134:67-75. 2005
    ..alpha-synuclein knock out (alpha-syn(ko)), alpha-synuclein-metallothionein triple knock out (alpha-syn-MTtko), weaver mutant (wv/wv) mice, and Ames dwarf mice to examine the role of peroxynitrite in the etiopathogenesis of Parkinson'..
  52. ncbi Multiple innervation of Purkinje cells by climbing fibers in the cerebellum of the Weaver Mutant Mouse
    F Crepel
    J Neurobiol 7:579-82. 1976
  53. ncbi Anatomical, physiological and biochemical studies on the cerebellum from mutant mice. III. Protein differences associated with the weaver, staggerer and nervous mutations
    J Mallet
    Brain Res 103:291-312. 1976
    The protein composition of subcellular fractions of the cerebella of normal and weaver, staggerer and nervous mutant mice and of X-irradiated rats are studied by polyacrylamide gel electrophoresis in sodium dodecyl sulphate...
  54. ncbi Plasticity of GABAergic terminals in Deiters' nucleus of weaver mutant and normal mice: a quantitative light microscopic study
    J Bäurle
    Department of Physiology, Freie Universitat Berlin, FRG
    Brain Res 591:305-18. 1992
    ..b>Weaver mutants, PCD mutants and the corresponding wild types were used to test for size alterations and differences in ..
  55. ncbi Glutamate dehydrogenase in cerebellar mutant mice: gene localization and enzyme activity in different tissues
    O Miret-Duvaux
    Laboratoire de Neurophysiologie Ontogénétique, Universite Pierre et Marie Curie, Paris, France
    J Neurochem 54:23-9. 1990
    ..system atrophies (MSAs), and murine cerebellar mutations like Purkinje cell degeneration, nervous, staggerer, weaver, and reeler...
  56. ncbi Development and death of external granular layer cells in the weaver mouse cerebellum: a quantitative study
    R J Smeyne
    Department of Anatomy, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    J Neurosci 9:1608-20. 1989
    Previous studies have identified the cerebellar granule cell as a primary site of gene action in the weaver mutant mouse. The temporal expression of the weaver mutant granule cell phenotype has not been fully investigated...
  57. ncbi Expression of the death-associated gene RP-8 in granule cell neurons undergoing postnatal cell death in the cerebellum of weaver mice
    G P Owens
    Department of Neurology, University of Colorado School of Medicine, Denver 80262, USA
    Brain Res Dev Brain Res 86:35-47. 1995
    ..We used in situ hybridization to look for RP-8 mRNA in the cerebella of weaver mice...
  58. ncbi Analysis of region-specific library constructed by sequence-independent amplification of microdissected fragments surrounding weaver (wv) gene on mouse chromosome 16
    J Wei
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202 5251
    Somat Cell Mol Genet 20:401-8. 1994
    ..Thirty-three clones were sequenced. None of them was found in GenBank. Our results demonstrate that this relatively simple method of microdissection and cloning can produce a library of good quality...
  59. ncbi Age-dependent alterations in dopamine content, tyrosine hydroxylase activity, and dopamine uptake in the striatum of the weaver mutant mouse
    J R Simon
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4887
    J Neurochem 62:543-8. 1994
    Mice of different ages and homozygous or heterozygous for the weaver gene (wv) were used to study the time course for the effect of the weaver gene on several striatal dopaminergic parameters...
  60. ncbi Cellular distribution of the RNA transcripts of a newly discovered gene in the brain of normal, weaver, Purkinje cell degeneration and reeler mutant mice as evidenced by in situ hybridization histochemistry
    M Kambouris
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis
    Brain Res Mol Brain Res 18:321-8. 1993
    After we identified several novel cDNAs by screening a neonatal (P1) heterozygous weaver (wv/+) cerebellar cDNA expression library with a rabbit anti-mouse granule cell antiserum, we characterized and sequenced one cDNA, GCAP-8 (standing ..
  61. ncbi Cerebellar and striatal dopamine receptors: effects of reeler and weaver murine mutations
    N T Panagopoulos
    Department of Biology, University of Patras, Greece
    J Neurosci Res 35:499-506. 1993
    The presence and the binding characteristics of D1 and D2 receptors were investigated in normal-reeler and normal-weaver mutant mice utilizing [3H]spiperone (D2 antagonist), [3H]SKF 38393 (D1 agonist), and [3H]DA as ligands...
  62. ncbi A high-density molecular genetic map around the weaver locus
    J H Millonig
    Rockefeller University, Laboratory of Developmental Neurobiology, New York, New York 10021, USA
    Mamm Genome 7:616-8. 1996
  63. pmc Weaver granule neurons are rescued by calcium channel antagonists and antibodies against a neurite outgrowth domain of the B2 chain of laminin
    P Liesi
    Laboratory of Molecular and Cellular Neurobiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA
    J Cell Biol 134:477-86. 1996
    The weaver mutation impairs migration of the cerebellar granular neurons and induces neuronal death during the first two weeks of postnatal life...
  64. ncbi Cell death in the midbrain of the murine mutation weaver
    S Roffler-Tarlov
    Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Neurosci 16:1819-26. 1996
    The midbrain of the adult homozygous weaver (wv/wv) mouse is notable for a reduction in the numbers of dopamine-containing cells in the substantia nigra (A9) and the retrorubral nucleus (A8)...
  65. ncbi Weaver mutant mouse cerebellar granule cells respond normally to chronic depolarization
    A Bjerregaard
    Laboratory of Neuropsychiatry Department of Pharmacology, University of Copenhagen, Rigshospitalet, Denmark
    Int J Dev Neurosci 15:155-62. 1997
    ..membrane depolarization and treatment with N-methyl-D-aspartate (NMDA) on cerebellar granule cells (CGCs) from weaver mutant mice and non-weaver litter-mates...
  66. ncbi Developmental expression of the GIRK family of inward rectifying potassium channels: implications for abnormalities in the weaver mutant mouse
    S C Chen
    Neurogenetics Program, Department of CNS Research, Hoffmann LaRoche, Nutley, NJ 07110, USA
    Brain Res 778:251-64. 1997
    ..gene, one of the GIRK family members, is the cause of the neurological and reproductive defects observed in the weaver (wv) mutant mouse...
  67. ncbi The weaver mutation causes a loss of inward rectifier current regulation in premigratory granule cells of the mouse cerebellum
    P Rossi
    Istituto di Fisiologia Generale, I 27100, Pavia, Italy
    J Neurosci 18:3537-47. 1998
    Considerable interest has recently focused on the weaver mutation, which causes inward rectifier channel alterations leading to profound impairment of neuronal differentiation and to severe motor dysfunction in mice (Hess, 1996)...
  68. ncbi Partial restoration of striatal GABAA receptor balance by functional mesencephalic dopaminergic grafts in mice with hereditary parkinsonism
    K Stasi
    Faculty of Medicine, University of Patras, Patras, 26500, Greece
    Exp Neurol 157:259-67. 1999
    Levels of inhibitory amino acid receptors were studied in the weaver (wv/wv) mouse model of dopamine (DA) deficiency after unilateral intrastriatal transplantation of fetal mesencephalic cell suspensions...
  69. ncbi G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase
    Natalie Lavine
    Centre for Addiction and Mental Health, Department of Pharmacology, Institute of Medical Science, University of Toronto, Ontario M5T 1R8, Canada
    J Biol Chem 277:46010-9. 2002
    ..The observation that several G protein-coupled receptors form stable complexes with their effectors suggests that this arrangement might be a general feature of G protein-coupled signal transduction...
  70. ncbi Expression of amino acid receptors and neural peptides in the weaver mouse brain
    Kleopatra Fragioudaki
    Department of Physiology, Faculty of Medicine, University of Patras, 26504 Patras, Greece
    Brain Res 1140:132-52. 2007
    ..of kainate and GABA(A) receptor subunits and the pre-proenkephalin and prodynorphin peptides in the brain of weaver mouse (a genetic model of dopamine deficiency) and (ii) immunocytochemistry in order to study the somatostatin-..
  71. ncbi Generation and survival of midbrain dopaminergic neurons in weaver mice
    Joaquin Marti
    Unidad de Citología e Histología, Facultad de Ciencias, Universidad Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Int J Dev Neurosci 25:299-307. 2007
    ..The wild-type (+/+) and homozygous weaver (wv/wv) mice used here were the offspring of pregnant dams injected with the radioactive precursor when the ..
  72. ncbi Weaver mutant mice exhibit long-term learning deficits under several measures of instrumental behavior
    Adam Derenne
    University of North Dakota, United States
    Physiol Behav 92:1002-9. 2007
    Homozygous weaver mutant mice (wv/wv) exhibit symptoms that parallel Parkinson's disease, including motor deficits and the destruction of dopaminergic neurons as well as degeneration in the cerebellum and hippocampus...
  73. pmc Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice
    Hans G Cruz
    Department of Basic Neurosciences, University of Geneva, CH 1211 Geneva, Switzerland
    J Neurosci 28:4069-77. 2008
    ..withdrawal syndrome was strongly attenuated, whereas morphine analgesia was mostly preserved in mice lacking both GIRK2 and GIRK3 (GIRK2/3(-/-) mice)...
  74. ncbi Alpha hydroxylation of lignoceric acid to cerebronic acid during brain development. Diminished hydroxylase activity in myelin-deficient mouse mutants
    S Murad
    J Biol Chem 250:5841-6. 1975
    ..The preparations of brains from wabbler-lethal, ducky, and weaver mice showed normal activity...
  75. ncbi Effect of the weaver mutation on the expression of dopamine membrane transporter, tyrosine hydroxylase and vesicular monoamine transporter in dopaminergic neurons of the substantia nigra and the ventral tegmental area
    C Adelbrecht
    INSERM U289, Bâtiment Nouvelle Pharmacie, Hôpital de la Satpêtrière, Paris, France
    Brain Res Mol Brain Res 43:291-300. 1996
    The adult homozygous weaver mutant mouse (wv/wv) is characterized by a loss of dopamine (DA) neurons in the nigrostriatal pathway...
  76. doi Differential maturation of GIRK2-expressing neurons in the mouse cerebellum
    Carolina Aguado
    Instituto de Investigación en Discapacidades Neurológicas, Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla La Mancha, Campus Biosanitario, Albacete, Spain
    J Chem Neuroanat 47:79-89. 2013
    ..To characterize this onset of expression, we examined the GIRK2 protein expression in mouse cerebellum by western blot, light microscopy immunohistochemistry and ..
  77. doi Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages
    Simon R W Stott
    Developmental Neurobiology, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Neurosci 33:8022-34. 2013
    ..These results extend previous findings and demonstrate a later role for Foxa genes in regulating the maintenance of dopaminergic phenotype in mDA neurons...
  78. ncbi Degeneration of mesencephalic dopamine neurons in weaver mutant mice
    B Ghetti
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202 5120
    Neurochem Int 20:305S-307S. 1992
  79. ncbi Pro-thyrotropin-releasing hormone concentrations in the brain of ataxic mice
    T Mitsuma
    Fourth Department of Internal Medicine, Aichi Medical University, Japan
    J Neurol Sci 98:163-7. 1990
    Concentrations of pro-thyrotropin-releasing hormone (pro-TRH) were studied in the brain of the Weaver ataxic mouse, the Purkinje cell degenerative mouse (pcd-ataxic mouse), the Staggerer ataxic mouse and the C3H mouse...
  80. ncbi Cerebellar synaptogenesis: what we can learn from mutant mice
    C Sotelo
    Laboratoire de Neuromorphologie, INSERM U 106, Hopital de la Salpetriere, Paris, France
    J Exp Biol 153:225-49. 1990
    ..In weaver and in the central ectopia of reeler, Purkinje cells form innumerable dendritic spines, despite the absence of ..
  81. ncbi Developmental expression and intracellular location of P400 protein characteristic of Purkinje cells in the mouse cerebellum
    N Maeda
    Division of Regulation of Macromolecular Function, Osaka University, Japan
    Dev Biol 133:67-76. 1989
    ..Immunohistochemistry of the cerebella of neurological mutant mice indicated that the Purkinje cells of reeler, weaver, and pcd mutant mice retain the ability to produce a large amount of P400 protein...
  82. ncbi [Elevated immunoreactive-somatostatin levels in the brain of ataxic mutant mice]
    K Matsui
    National Institute of Neuroscience, N C N P, Tokyo, Japan
    Jikken Dobutsu 37:263-8. 1988
    ..IR-SRIF) levels were investigated in the brain of 4 types of ataxic mice (Rolling Mouse Nagoya, Weaver, PCD, Staggerer) with different cerebellar pathologies...
  83. ncbi Sequence of developmental abnormalities leading to granule cell deficit in cerebellar cortex of weaver mutant mice
    P Rakic
    J Comp Neurol 152:103-32. 1973
  84. ncbi Neuronal differentiation in cultures of weaver (wv) mutant mouse cerebellum
    M Willinger
    J Supramol Struct Cell Biochem 17:79-86. 1981
    In the present study we report for the first time a weaver (wv) gene dose effect on neuron survival and neurite formation in vitro...
  85. ncbi New mouse dw allele: genetic location and effects on lifespan and growth hormone levels
    E M Eicher
    J Hered 71:187-90. 1980
    ..Linkage experiments designed to assign the dw gene, together with another gene weaver (wv), were successful in that both were found to be on chromosome 16...
  86. ncbi Endogenous serotonin release from the dopamine-deficient striatum of the weaver mutant mouse
    E H Stotz-Potter
    Department of Psychiatry Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Neurochem Res 20:821-6. 1995
    In addition to an altered dopaminergic input, the striatum of the weaver mutant mouse (wv/wv) has increased serotonin tissue content and uptake compared to the wild-type mouse (+/+)...
  87. ncbi Systematic differences in time of dopaminergic neuron origin between normal mice and homozygous weaver mutants
    S A Bayer
    Department of Biology, Indiana Purdue University, Indianapolis 46202, USA
    Exp Brain Res 105:200-8. 1995
    ..hydroxylase and [3H]thymidine autoradiography were combined in wild-type mice and in mice homozygous for the weaver mutant gene (wv) to see whether the neurogenetic patterns of midbrain dopaminergic neurons was normal in the ..
  88. ncbi A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation
    N Patil
    Department of Genetics, Stanford University Medical School, California 94305 5120, USA
    Nat Genet 11:126-9. 1995
    ..b>Weaver mice harbour a mutation that blocks neuronal differentiation just after cessation of cell division, prior to cell ..
  89. pmc Selective vulnerability of late-generated dopaminergic neurons of the substantia nigra in weaver mutant mice
    S A Bayer
    Department of Biology, Indiana Purdue University, Indianapolis 46202 5132, USA
    Proc Natl Acad Sci U S A 92:9137-40. 1995
    In homozygous weaver (wv/wv) mutant mice, nearly 50% of the dopaminergic substantia nigra neurons degenerate by postnatal day 20...
  90. ncbi Ventral mesencephalic grafts in the neostriatum of the weaver mutant mouse: structural molecule and receptor studies
    L C Triarhou
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Cell Transplant 4:39-48. 1995
    ..were prepared from E12 wild-type (+/+) mouse embryos and stereotaxically implanted into the dorsal neostriatum of weaver mutant mice (wv/wv), which have a genetic mesostriatal dopamine (DA) deficiency...
  91. ncbi cDNA approaches to isolation of the mouse mutant weaver gene
    M E Hodes
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202
    Neurochem Res 19:1359-62. 1994
    The mouse autosomal recessive mutant gene weaver (wv) results in abnormalities in cerebellum, substantia nigra and testis...
  92. ncbi Dopamine-depleting effects of MPTP and reserpine in weaver mutant mice
    J A Richter
    Department of Pharmacology, Indiana University School of Medicine, Indianapolis
    Mol Chem Neuropathol 20:219-28. 1993
    The number of nigral dopamine neurons and striatal dopamine levels are reduced by 70% in the adult weaver mutant mouse (wv/wv), whereas these parameters are essentially unchanged in the heterozygote (wv/+)...
  93. ncbi Calbindin D-28k in the lateral vestibular nucleus of mutant mice as a tool to reveal Purkinje cell plasticity
    J Bäurle
    Department of Physiology, Freie Universitat Berlin, Germany
    Neurosci Lett 167:85-8. 1994
    ..In PCD an almost complete loss of CaBP+ fibres and terminals in the dLVN compared to the wildtype and the Weaver mutant was present...
  94. ncbi Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice
    Y Ryo
    Department of Molecular Neurobiology, University of Tokyo, Japan
    J Neurosci Res 36:19-32. 1993
    ..Both receptors are expressed to a fair degree in weaver mutant cerebellum despite granule cell degeneration...
  95. ncbi Regional distribution of amyloid beta-protein precursor, growth-associated phosphoprotein-43 and microtubule-associated protein 2 messenger RNAs in the nigrostriatal system of normal and Weaver mutant mice and effects of ventral mesencephalic grafts
    C Sola
    Preclinical Research, Sandoz Pharma AG, Basel, Switzerland
    Eur J Neurosci 5:1442-54. 1993
    ..GAP-43) and microtubule-associated protein 2 (MAP2) in the mesostriatal system of normal (+/+) and weaver (wv/wv) mutant mice, which lose mesencephalic dopamine neurons...
  96. ncbi Regional distribution of the alternatively spliced isoforms of beta APP RNA transcript in the brain of normal, heterozygous and homozygous weaver mutant mice as revealed by in situ hybridization histochemistry
    C Sola
    Preclinical Research, Sandoz Pharma AG, Basel, Switzerland
    Brain Res Mol Brain Res 17:340-6. 1993
    ..APP) RNA transcripts was studied by in situ hybridization histochemistry in normal, heterozygous and homozygous weaver (wv) mutant mice, which lose midbrain dopamine (DA) neurons, cerebellar granule cells, and Purkinje cells...
  97. ncbi Morphological abnormalities in the hippocampus of the weaver mutant mouse
    M Sekiguchi
    Department of Morphology, Tokai University School of Medicine, Kanagawa, Japan
    Brain Res 696:262-7. 1995
    The lamination of the hippocampus in the homozygous B6CBA weaver mouse (wv/wv) was compared with that in normal B6CBA littermates (+/+) and C57BL/6J mice using Nissl and Timm's staining...
  98. ncbi Early postnatal changes of the dopaminergic mesencephalic neurons in the weaver mutant mouse
    C Verney
    INSERM U 106, Hopital Salpetriere, Paris, France
    Brain Res Dev Brain Res 89:115-9. 1995
    In adult weaver (wv) mutant mice up to 70% of the mesostriatal dopaminergic neurons are lost and major alterations of the dopaminergic dendrites of the substantia nigra have been described...
  99. ncbi Identification of the weaver mouse mutation: the end of the beginning
    E J Hess
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, 17033, USA
    Neuron 16:1073-6. 1996
  100. ncbi Phenotypic effects of the weaver gene are evident in the embryonic cerebellum but not in the ventral midbrain
    S A Bayer
    Department of Biology, Indiana Purdue University, Indianapolis 46202, USA
    Brain Res Dev Brain Res 96:130-7. 1996
    ..the cerebellum and the dopaminergic neurons in the ventral midbrain, is a well characterized action of the weaver gene...
  101. ncbi Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain
    Y J Liao
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143 0724, USA
    J Neurosci 16:7137-50. 1996
    The weaver (wv) gene (GIRK2) is a member of the G-protein-gated inwardly rectifying potassium (GIRK) channel family, known effectors in the signal transduction pathway of neurotransmitters such as acetylcholine, dopamine, opioid peptides, ..

Research Grants3

  1. UBIQUINONE AND MITOCHONDRIAL OXIDATIVE DISORDERS OF AGIN
    Manuchair Ebadi; Fiscal Year: 2003
    ..The completion of these studies will undoubtedly provide additional items of information on reactive oxygen species-induced damage of mitochondrial DNA and the protective effects of coenzyme Q10(ubiquinol) to minimize it. ..
  2. PINEAL OPIOID RECEPTORS & ANALGESIC ACTION OF MELATONIN
    Manuchair Ebadi; Fiscal Year: 2002
    ..Therefore, future research must synthesize highly efficacious melatonin analogues capable of providing maximum analgesia and hopefully being devoid of addiction liability now associated with currently available narcotics. ..