Wnt10a

Summary

Gene Symbol: Wnt10a
Description: wingless-type MMTV integration site family, member 10A
Alias: protein Wnt-10a, wingless related MMTV integration site 10a
Species: mouse

Top Publications

  1. pmc Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development
    Jian Sima
    Laboratory of Genetics and Genomics, NIA NIH IRP, 251 Bayview Blvd, room 10B014, Baltimore, MD 21224, USA
    Development 143:4723-4735. 2016
  2. ncbi Wnt/β-Catenin Signaling Exacerbates Keloid Cell Proliferation by Regulating Telomerase
    Dongmei Yu
    Plastic and Cosmetic Center, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Cell Physiol Biochem 39:2001-2013. 2016
  3. pmc Profibrotic role of WNT10A via TGF-β signaling in idiopathic pulmonary fibrosis
    Keishi Oda
    Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1 1, Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka, 807 8555, Japan
    Respir Res 17:39. 2016
  4. pmc Ectodysplasin/NF-κB Promotes Mammary Cell Fate via Wnt/β-catenin Pathway
    Maria Voutilainen
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    PLoS Genet 11:e1005676. 2015
  5. pmc Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors
    Wendy M Knosp
    Matrix and Morphogenesis Section, NIDCR, NIH, Bethesda, MD 20892, USA
    Dev Cell 32:667-77. 2015
  6. pmc WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma
    Apple Long
    Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA, Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA and Cancer Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Carcinogenesis 36:598-606. 2015
  7. doi Down-regulation of Wnt10a by RNA interference inhibits proliferation and promotes apoptosis in mouse embryonic palatal mesenchymal cells through Wnt/β-catenin signaling pathway
    Cuijuan Feng
    Department of Orthodontics, School of Stomatology, China Medical University, 117 North Nanjing Street, Shenyang, 110001, People s Republic of China
    J Physiol Biochem 69:855-63. 2013
  8. pmc Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism
    William P Cawthorn
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Bone 50:477-89. 2012
  9. pmc Roles of heparan sulfate sulfation in dentinogenesis
    Satoru Hayano
    Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama 700 8525, Japan
    J Biol Chem 287:12217-29. 2012
  10. pmc Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis
    LiFeng Wang
    Adipocyte Biology and Gene Regulation Section, Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 32:45-59. 2013

Scientific Experts

  • Jian Sima
  • Martyn J James
  • K Luukko
  • J Pispa
  • C Hayes
  • Irma Thesleff
  • Takashi Yamashiro
  • Keishi Oda
  • Dongmei Yu
  • Maria Voutilainen
  • Apple Long
  • Wendy M Knosp
  • Sarah E Millar
  • LiFeng Wang
  • Hiroto Izumi
  • Cuijuan Feng
  • Yang Liu
  • Satoru Hayano
  • Marja L Mikkola
  • Hong Xiang Liu
  • William P Cawthorn
  • Ruth Schmidt-Ullrich
  • Congxing Lin
  • Yoshihiro Yasuniwa
  • Marika Suomalainen
  • Masahiro Saito
  • Yuhang Zhang
  • Xiuping Yu
  • Dennis R Warner
  • Thomas Andl
  • Steven Hoseong Yang
  • Julie Bayle
  • Stefano Piccolo
  • Ambra A Zaghetto
  • Kersti Lilleväli
  • Edward E Morrisey
  • Tomohiro Narita
  • Othman A Mohamed
  • Daniel Dufort
  • Hiroshi Ishimoto
  • Hong Liu
  • Lijun Hao
  • Kazuhiro Yatera
  • Tetsuya Hanaka
  • Takaaki Ogoshi
  • Shingo Noguchi
  • Sohsuke Yamada
  • Sai Luo
  • Jian Yuan
  • Yong Shang
  • Hiroshi Mukae
  • Shuang Ding
  • Hiroyuki Nakao
  • Anil K Rustgi
  • Véronique Giroux
  • Sarah M Knox
  • Elisa Rysti
  • Koji Tanaka
  • Ju Seog Lee
  • Vera Shirokova
  • Kelly A Whelan
  • Matthew P Hoffman
  • Päivi H Lindfors
  • Ewelina Trela
  • Isabelle M A Lombaert
  • Marie Pier Tetreault
  • Darielle Lönnblad
  • Kathryn E Hamilton
  • Vaishali N Patel
  • Teresa Elo
  • Andres J Klein-Szanto
  • Hiroshi Nakagawa
  • Candace L Haddox
  • Pascal Schneider
  • Klaus Kratochwil
  • Rudolf Grosschedl
  • Johanna Laurikkala
  • Tuija Mustonen
  • Juan Galceran
  • Joel Weidenfeld
  • Ji Eun Lee
  • Weiqun Peng
  • Kai Ge
  • Sean Grullon
  • Qiang Liu
  • Anne Baldridge
  • Shiliyang Xu
  • Dong Han
  • Zhongfei Xu
  • Dan Zhang

Detail Information

Publications42

  1. pmc Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development
    Jian Sima
    Laboratory of Genetics and Genomics, NIA NIH IRP, 251 Bayview Blvd, room 10B014, Baltimore, MD 21224, USA
    Development 143:4723-4735. 2016
    ..Thus, the dynamic state of Dkk4 itself and its interaction with Lrp6 modulates Wnt function during MG development, with a novel limitation of Dkk4 action by proteolytic cleavage...
  2. ncbi Wnt/β-Catenin Signaling Exacerbates Keloid Cell Proliferation by Regulating Telomerase
    Dongmei Yu
    Plastic and Cosmetic Center, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Cell Physiol Biochem 39:2001-2013. 2016
    ..Our goal was to investigate the relationship between keloid and telomerase as well as clarifying the influence of Wnt/β-catenin signaling on keloid cell proliferation...
  3. pmc Profibrotic role of WNT10A via TGF-β signaling in idiopathic pulmonary fibrosis
    Keishi Oda
    Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1 1, Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka, 807 8555, Japan
    Respir Res 17:39. 2016
    WNT/β-catenin signaling plays an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF); however, the role of WNT10A via transforming growth factor (TGF)-β signaling remains unclear.
  4. pmc Ectodysplasin/NF-κB Promotes Mammary Cell Fate via Wnt/β-catenin Pathway
    Maria Voutilainen
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    PLoS Genet 11:e1005676. 2015
    ..Using an ex vivo culture system, we show that suppression of canonical Wnt signalling leads to a dose-dependent inhibition of supernumerary placodes in K14-Eda tissue explants. ..
  5. pmc Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors
    Wendy M Knosp
    Matrix and Morphogenesis Section, NIDCR, NIH, Bethesda, MD 20892, USA
    Dev Cell 32:667-77. 2015
    ..Thus, K5+ progenitors produce Wnt signals to establish the PSG-epithelial communication required for organ innervation and progenitor cell maintenance...
  6. pmc WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma
    Apple Long
    Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA, Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA and Cancer Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Carcinogenesis 36:598-606. 2015
    ..b>WNT10A was found to be >4-fold upregulated in the invasive front...
  7. doi Down-regulation of Wnt10a by RNA interference inhibits proliferation and promotes apoptosis in mouse embryonic palatal mesenchymal cells through Wnt/β-catenin signaling pathway
    Cuijuan Feng
    Department of Orthodontics, School of Stomatology, China Medical University, 117 North Nanjing Street, Shenyang, 110001, People s Republic of China
    J Physiol Biochem 69:855-63. 2013
    ..Both environmental and genetic factors are involved in this disorder. Here, we investigated the function of Wnt10a in proliferation and apoptosis of mouse embryonic palatal mesenchymal (MEPM) cells...
  8. pmc Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism
    William P Cawthorn
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Bone 50:477-89. 2012
    ..In this study, we identify Wnt6 and Wnt10a as additional Wnt family members that, like Wnt10b, are downregulated during development of white adipocytes in ..
  9. pmc Roles of heparan sulfate sulfation in dentinogenesis
    Satoru Hayano
    Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama 700 8525, Japan
    J Biol Chem 287:12217-29. 2012
    ..We also show that Wnt10a protein binds to cell surface HSPGs in odontoblasts, and interference with HS sulfation decreases the binding ..
  10. pmc Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis
    LiFeng Wang
    Adipocyte Biology and Gene Regulation Section, Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 32:45-59. 2013
    ..Interestingly, G9a represses PPARγ expression in an HMT activity-dependent manner but facilitates Wnt10a expression independent of its enzymatic activity...
  11. pmc Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling
    Steven Hoseong Yang
    Department of Dermatology and Comprehensive Cancer Center, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:1130-5. 2008
    ....
  12. pmc Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development
    Hong Xiang Liu
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Dev Biol 361:39-56. 2012
    ....
  13. doi Down-regulation of Wnt10a affects odontogenesis and proliferation in mesenchymal cells
    Yang Liu
    Department of Prosthodontics, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, PR China
    Biochem Biophys Res Commun 434:717-21. 2013
    The WNT10a mutation has been found in patients with abnormal odontogenesis. In mice, Wnt10a expression is found in the tooth germ, but its role has not yet been elucidated. We aimed to investigate the role of Wnt10a in odontogenesis...
  14. ncbi Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth
    H R Dassule
    The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Biol 202:215-27. 1998
    ..In this paper we have investigated the role of four epithelial signaling molecules, Bmp2, Shh, Wnt10a, and Wnt10b, in the early inductive cascades that govern tooth development...
  15. pmc The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatus
    Congxing Lin
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 356:40-50. 2011
    ..We provide genetic evidence that disruption of either signaling pathway results in severe microglossia. Altogether, we demonstrate a dynamic role for Wnt-β-Catenin signaling in the development of the oral apparatus...
  16. pmc Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway
    Yoshihiro Yasuniwa
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    PLoS ONE 5:e15330. 2010
    ..DNA microarray analysis showed enhanced expression of WNT10A, and our subsequent study revealed that WNT10A stimulates the growth of both microvascular endothelial cells and ..
  17. doi Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells
    Marika Suomalainen
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Dyn 239:364-72. 2010
    ..We conclude that epithelial stem cells in the mouse incisors are not regulated directly by Wnt/beta-catenin signaling...
  18. pmc Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction
    Yuhang Zhang
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Cell 17:49-61. 2009
    ..We show that maintenance of localized expression of Wnt10b and Wnt10a requires NF-kappaB signaling, providing a molecular explanation for the latter observation, and identify Wnt10b as ..
  19. pmc Expression of Wnts in the developing murine secondary palate
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, Kentucky 40292, USA
    Int J Dev Biol 53:1105-12. 2009
    ..The expression of 5 Wnt family members was found to be temporally regulated. Moreover, these Wnts had unique spatio-temporal patterns of expression which suggested possible roles in palatal ontogeny...
  20. pmc Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration
    Xiuping Yu
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Prostate 69:249-62. 2009
    ..Although stabilizing mutations in APC and beta-Catenin are rare in primary prostate tumors, recent studies suggest that cytoplasmic/nuclear beta-Catenin is associated with advanced, metastatic, hormone-refractory prostate carcinoma...
  21. pmc FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice
    Klaus Kratochwil
    Institute of Molecular Biology, Austrian Academy of Sciences, 5020 Salzburg, Austria
    Genes Dev 16:3173-85. 2002
    ..epithelium of the developmentally arrested Lef1(-/-) tooth rudiments fails to express Fgf4, Shh, and Bmp4, but not Wnt10a. We identify the Fgf4 gene as a direct transcriptional target for LEF1 and show that beads soaked with recombinant ..
  22. ncbi Murine Wnt10a and Wnt10b: cloning and expression in developing limbs, face and skin of embryos and in adults
    J Wang
    Division of Hematology Oncology, Childrens Hospital Los Angeles Research Institute, California 90027, USA
    Oncogene 13:1537-44. 1996
    ..We report the isolation of cDNAs for a novel murine Wnt gene, Wnt10a, and for two alternatively spliced transcripts of Wnt10b, as well as analyses of the expression patterns of these ..
  23. ncbi The Wnts
    J J Loureiro
    Department of Biology, University of North Carolina at Chapel Hill, 27599 3280, USA
    Curr Biol 9:R4. 1999
  24. ncbi Molecular genetic studies of Wnt signaling in the mouse
    M Uusitalo
    Faculties of Science and Medicine, University of Oulu, Oulu, 90570, Finland
    Exp Cell Res 253:336-48. 1999
  25. ncbi Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF
    J Pispa
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Biol 216:521-34. 1999
    ..Instead FGF-10 partially restored morphogenesis and stimulated the development of additional tooth cusps in cultured Tabby molars...
  26. ncbi Expression patterns of Wnt genes in mouse gut development
    H Lickert
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108, Freiburg, Germany
    Mech Dev 105:181-4. 2001
    ..5. Wnt11 is highly expressed at the gastro-esophageal junctions, while Wnt4 is found in the epithelium lining the pyloric region of the stomach but not in the epithelium of the prospective gland region...
  27. ncbi Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis
    S Reddy
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mech Dev 107:69-82. 2001
    ..These results identify candidates for several key follicular signals and suggest that WNT and SHH signaling pathways interact to regulate hair follicle morphogenesis...
  28. ncbi A high-resolution genetic, physical, and comparative gene map of the doublefoot (Dbf) region of mouse chromosome 1 and the region of conserved synteny on human chromosome 2q35
    C Hayes
    Medical Research Council, Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, Didcot, Oxon, OX11 0RD, UK
    Genomics 78:197-205. 2001
    ..These genes include those encoding known developmental signaling molecules such as WNT proteins and IHH, and we provide evidence that these genes are candidates for the Dbf mutation...
  29. ncbi The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium
    Joel Weidenfeld
    Department of Medicine, Molecular Cardiology Research Center, and the Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:21061-70. 2002
    ..Together, these results suggest that WNT7b gene expression in the lung epithelium is regulated in a combinatorial fashion by TTF-1, GATA6, and Foxa2...
  30. ncbi Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar
    Johanna Laurikkala
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Development 129:2541-53. 2002
    ..In conclusion, we suggest that Eda and Edar are associated with the onset of ectodermal patterning and that ectodysplasin/edar signaling also regulates the morphogenesis of hair follicles...
  31. ncbi Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth
    Tuija Mustonen
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki FIN 00014, Finland
    Dev Biol 248:281-93. 2002
    ..We conclude that Lunatic fringe may play a role in boundary formation of the enamel knot and that Notch-signaling in the dental epithelium is regulated by mesenchymal FGFs and BMP...
  32. ncbi Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth
    Keijo Luukko
    Department of Anatomy and Cell Biology, University of Bergen, Arstadveien 19, N 5009, Bergen, Norway
    Mech Dev 120:270-6. 2003
    ..Moreover, our results suggest that Slit1 signaling may be involved in the regulation of molar tooth shape by regulating epithelial cell proliferation and formation of EFA of the crown...
  33. ncbi Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina
    Hong Liu
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Dev Dyn 227:323-34. 2003
    ....
  34. ncbi Expression and estradiol regulation of Wnt genes in the mouse blastocyst identify a candidate pathway for embryo-maternal signaling at implantation
    Othman A Mohamed
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada H3A 1A1
    Biol Reprod 71:417-24. 2004
    ....
  35. ncbi Wnt10a is involved in AER formation during chick limb development
    Tomohiro Narita
    Department of Molecular Biology, Kawasaki Medical School, Matsushima, Kurashiki, Japan
    Dev Dyn 233:282-7. 2005
    ..We report identification and involvement of Wnt10a in AER formation during chick limb development...
  36. ncbi Gata3 is required for early morphogenesis and Fgf10 expression during otic development
    Kersti Lilleväli
    Institute of Biotechnology, University of Helsinki, Viikinkaari 9, 00710 Helsinki, Finland
    Mech Dev 123:415-29. 2006
    ..Inactivation of Gata3 leads also to a loss of Fgf10 expression in otic epithelium and auditory ganglion demonstrating that Gata3 is an important regulator of Fgf-signalling during otic development...
  37. ncbi Different roles of Runx2 during early neural crest-derived bone and tooth development
    Martyn J James
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    J Bone Miner Res 21:1034-44. 2006
    ..In vitro experiments determined that Runx2 is a part of the FGF and BMP signaling pathways in tooth and bone development, respectively...
  38. ncbi Wnt10a regulates dentin sialophosphoprotein mRNA expression and possibly links odontoblast differentiation and tooth morphogenesis
    Takashi Yamashiro
    Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Differentiation 75:452-62. 2007
    We have explored the role of Wnt signaling in dentinogenesis of mouse molar teeth. We found that Wnt10a was specifically associated with the differentiation of odontoblasts and that it showed striking colocalization with dentin ..
  39. ncbi Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis
    Julie Bayle
    Department of Medicine, Rheumatology Section, Boston University School of Medicine, Arthritis Center, Boston, Massachusetts 02118, USA
    J Invest Dermatol 128:871-81. 2008
    ..Lesional skin from SSc patients also showed large increases in SFRP4 mRNA and protein levels in the deep dermis compared to healthy skin, suggesting that the Wnt pathway might regulate skin fibrosis in SSc...
  40. pmc Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections
    Ambra A Zaghetto
    Dulbecco Telethon Institute Consiglio Nazionale delle Ricerche Institute for Biomedical Technologies Milano, 20090 Segrate, Italy
    J Neurosci 27:9757-68. 2007
    ..These data reveal a novel function for Wnt signaling in the establishment of periphery-CNS olfactory connections and highlight a complex interplay between cells of different embryonic origin for ORN axon connectivity...