Wnt11

Summary

Gene Symbol: Wnt11
Description: wingless-type MMTV integration site family, member 11
Alias: protein Wnt-11, wingless-related MMTV integration site 11
Species: mouse

Top Publications

  1. ncbi Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis
    S Reddy
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mech Dev 107:69-82. 2001
  2. ncbi The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium
    Joel Weidenfeld
    Department of Medicine, Molecular Cardiology Research Center, and the Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:21061-70. 2002
  3. pmc Downregulation of Spry-1, an inhibitor of GDNF/Ret, causes angiotensin II-induced ureteric bud branching
    Ihor V Yosypiv
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Kidney Int 74:1287-93. 2008
  4. ncbi Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips
    A Kispert
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 122:3627-37. 1996
  5. ncbi Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung
    M Lako
    Department of Human Genetics, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Gene 219:101-10. 1998
  6. pmc Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter
    Y Miyazaki
    Department of Pediatrics, Department of Pathology, Department of Cell Biology, and Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 105:863-73. 2000
  7. ncbi Characterization of Pax-2 regulatory sequences that direct transgene expression in the Wolffian duct and its derivatives
    S Kuschert
    Abt für Molekulare Embryologie, Max Planck Institut fur Immunbiologie, Stubeweg 51, Freiburg, 79108, Germany
    Dev Biol 229:128-40. 2001
  8. pmc Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis
    E de Graaff
    Division of Developmental Neurobiology, Medical Research Council MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Genes Dev 15:2433-44. 2001
  9. ncbi Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
    Arindam Majumdar
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 130:3175-85. 2003
  10. ncbi Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development
    Lijun Chi
    Biocenter Oulu and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, PO Box 3000, FIN 90014 Oulu, Finland
    Development 131:3345-56. 2004

Research Grants

  1. Towards renal regeneration
    Melissa Little; Fiscal Year: 2004

Scientific Experts

  • Charlotte Dean
  • Ming Chen
  • Stephane D Vincent
  • Stanley Nattel
  • Ethan David Cohen
  • Carrie Fathke
  • Nina Perälä
  • Raivo Raid
  • Kanako Hayashi
  • Kristopher R Schwab
  • R Spörle
  • M H Little
  • Ihor V Yosypiv
  • Alain Dabdoub
  • Cathy Mendelsohn
  • M Albert Basson
  • P D Burbelo
  • Darren Bridgewater
  • Andrew P McMahon
  • Odysse Michos
  • Thomas J Carroll
  • Frank Costantini
  • Jason E Cain
  • Norman D Rosenblum
  • Satu Kuure
  • Lizhu Lin
  • Chen Leng Cai
  • Lijun Chi
  • Abdul Soofi
  • Wenlai Zhou
  • Seppo J Vainio
  • Irina I Nagy
  • Gregory R Dressler
  • Alexandre Gonçalves
  • Jing Yu
  • Arindam Majumdar
  • Wei Liu
  • Walter Birchmeier
  • Sylvia Evans
  • Brice Bellessort
  • Tanvi Sinha
  • John Snowball
  • Robert A H van de Ven
  • Felix J Boivin
  • Joseph A Bisson
  • Xiaoxue Zhang
  • Akio Kobayashi
  • David Grote
  • Michael G Rosenfeld
  • Sarah E Millar
  • Guangping Tai
  • Emma R Andersson
  • Ju Chen
  • Zhifeng Zhang
  • Minoti Hiremath
  • Thantrira Porntaveetus
  • Keiko Ainoya
  • Hong Xiang Liu
  • Susan M Kiefer
  • Seppo Vainio
  • Daniel Dufort
  • Peng Zhang
  • Shi Zuo
  • Dong Hua Yang
  • Yasuaki Mohri
  • Anthony Wynshaw-Boris
  • Xuguang Nie
  • Antoine Reginensi
  • Xin Ye
  • Noriyuki Sugiyama
  • Joachim Herz
  • Vidya K Nagalakshmi
  • Regina Willecke
  • Xingyin Liu
  • Roxana Ola
  • Antti Railo
  • Fiona Haxho
  • Epshita Islam
  • Ludmilla Lokmane
  • Cristina Cebrian
  • Yukako Uchiyama
  • Courtney M Karner
  • Qun Ren
  • Deborah Hyink
  • Marika Suomalainen
  • Jun Wang
  • VIVETTE D'AGATI
  • Kirsi Sainio
  • Fen Wang
  • Jue Zhang

Detail Information

Publications119 found, 100 shown here

  1. ncbi Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis
    S Reddy
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mech Dev 107:69-82. 2001
    ..These results identify candidates for several key follicular signals and suggest that WNT and SHH signaling pathways interact to regulate hair follicle morphogenesis...
  2. ncbi The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium
    Joel Weidenfeld
    Department of Medicine, Molecular Cardiology Research Center, and the Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:21061-70. 2002
    ..Together, these results suggest that WNT7b gene expression in the lung epithelium is regulated in a combinatorial fashion by TTF-1, GATA6, and Foxa2...
  3. pmc Downregulation of Spry-1, an inhibitor of GDNF/Ret, causes angiotensin II-induced ureteric bud branching
    Ihor V Yosypiv
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Kidney Int 74:1287-93. 2008
    ..kidney development is the c-Ret receptor tyrosine kinase whose ligand is GDNF and whose downstream target is Wnt11. We determined whether angiotensin II, an inducer of ureteric bud branching in vitro, influences the GDNF/c-Ret/..
  4. ncbi Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips
    A Kispert
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 122:3627-37. 1996
    ..We suggest that Wnt-11 acts as an autocrine factor within the ureter epithelium and that its expression is regulated at least in part by proteoglycans...
  5. ncbi Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung
    M Lako
    Department of Human Genetics, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Gene 219:101-10. 1998
    ..We have recently isolated the full-length cDNA sequence of a new human WNT gene, WNT11, investigated its genomic organisation and performed detailed expression studies in early human embryos...
  6. pmc Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter
    Y Miyazaki
    Department of Pediatrics, Department of Pathology, Department of Cell Biology, and Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 105:863-73. 2000
    ..The other is to promote the elongation of the branching ureter within the metanephros, thereby promoting kidney morphogenesis...
  7. ncbi Characterization of Pax-2 regulatory sequences that direct transgene expression in the Wolffian duct and its derivatives
    S Kuschert
    Abt für Molekulare Embryologie, Max Planck Institut fur Immunbiologie, Stubeweg 51, Freiburg, 79108, Germany
    Dev Biol 229:128-40. 2001
    ....
  8. pmc Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis
    E de Graaff
    Division of Developmental Neurobiology, Medical Research Council MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Genes Dev 15:2433-44. 2001
    ..Our findings show that RET9 and RET51 have different signaling properties in vivo and define specific temporal and spatial requirements of c-Ret function during renal development and histogenesis of the enteric nervous system...
  9. ncbi Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
    Arindam Majumdar
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 130:3175-85. 2003
    ..b>Wnt11, a member of the Wnt superfamily of secreted glycoproteins, which have important regulatory functions during ..
  10. ncbi Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development
    Lijun Chi
    Biocenter Oulu and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, PO Box 3000, FIN 90014 Oulu, Finland
    Development 131:3345-56. 2004
    ..The experimentally induced dysmorphology associated with deregulated expression of Wnt11, Gdnf and Fgf7 genes in the early stages of organogenesis indicated a crucial role for sprouty function in ..
  11. ncbi Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction
    M Albert Basson
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, USA
    Dev Cell 8:229-39. 2005
    ..These results demonstrate the importance of negative feedback regulation of RTK signaling during kidney induction and suggest that failures in feedback control may underlie some human congenital kidney malformations...
  12. ncbi Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos
    Qinghua Tao
    Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Cell 120:857-71. 2005
    ..First, we identify Wnt11 as the initiating signal. Second, we show that activation requires the glycosyl transferase X.EXT1...
  13. ncbi Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
    Akio Kobayashi
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:2809-23. 2005
    ..We also demonstrate that the nephric duct is essential for the elongation and maintenance of the adjacent Mullerian duct, the anlage of the female reproductive tract...
  14. ncbi Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system
    Thomas J Carroll
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Dev Cell 9:283-92. 2005
    ..Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system...
  15. pmc Wnt3a links left-right determination with segmentation and anteroposterior axis elongation
    Masa aki Nakaya
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick, NIH Frederick, MD 21702, USA
    Development 132:5425-36. 2005
    ..Thus, Wnt3a links the segmentation clock and AP axis elongation with key left-determining events, suggesting that Wnt3a is an integral component of the trunk organizer...
  16. pmc Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney
    Michelle Self
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    EMBO J 25:5214-28. 2006
    ..We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud...
  17. ncbi Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis
    Odysse Michos
    Developmental Genetics, DKBW Centre for Biomedicine, University of Basel Medical Faculty, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Development 134:2397-405. 2007
    ..All epithelial buds express Wnt11, and Gdnf is significantly upregulated in the surrounding mesenchyme, indicating that epithelial-mesenchymal (e-m) ..
  18. ncbi Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2
    Wenlai Zhou
    Howard Hughes Medical Institute and Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Nat Genet 39:1225-34. 2007
    ..Here, we define a transcriptional pathway important in noncanonical Wnt signaling. We have found that Wnt11 is a direct target of a canonical beta-catenin pathway in developing heart and that Wnt11 mutants show cardiac ..
  19. doi Canonical WNT/beta-catenin signaling is required for ureteric branching
    Darren Bridgewater
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Dev Biol 317:83-94. 2008
    ..Together, these data demonstrate that beta-catenin performs essential functions during renal branching morphogenesis via control of a hierarchy of genes that control ureteric branching...
  20. doi Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease
    Sakura Saburi
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto M5G 1X5, Canada
    Nat Genet 40:1010-5. 2008
    ..In addition, Fat4 represses Fjx1 expression, indicating that Fat signaling is conserved. Together, these data suggest that Fat4 regulates vertebrate PCP and that loss of PCP signaling may underlie some cystic diseases in humans...
  21. pmc GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells
    Jason E Cain
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Towers, Toronto, Ontario, Canada
    PLoS ONE 4:e7313. 2009
    ..Ureteric tip cells are remarkable for abnormal morphology and impaired expression of Ret and Wnt11, markers of tip cell differentiation...
  22. pmc Kidney development in the absence of Gdnf and Spry1 requires Fgf10
    Odysse Michos
    Department of Genetics and Development, Columbia University, New York, New York, USA
    PLoS Genet 6:e1000809. 2010
    ..In contrast to GDNF or FGF10, Etv4 and Etv5 represent a critical node in the RTK signaling network that cannot by bypassed by reducing the negative regulation of upstream signals...
  23. pmc Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome
    Courtney M Karner
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e10418. 2010
    ..Multiple signaling pathways must be integrated to ensure proper timing and location of the ureteric bud formation...
  24. pmc Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney
    Vidya K Nagalakshmi
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Kidney Int 79:317-30. 2011
    ..Dicer removal also disrupted branching morphogenesis with the phenotype correlating with downregulation of Wnt11 and c-Ret expression at ureteric tips...
  25. doi Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney
    Nina Perälä
    Institute of Biomedicine Medical Biochemistry and Developmental Biology, Biomedicum Helsinki, PO Box 63, FI 00014 University of Helsinki, Finland
    Differentiation 81:81-91. 2011
    ....
  26. pmc Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis
    Satu Kuure
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS Genet 6:e1001176. 2010
    ..The results indicate that ADF activity, provided by either cofilin1 or destrin, is essential in UB epithelial cells for normal growth and branching...
  27. pmc The GDNF target Vsnl1 marks the ureteric tip
    Roxana Ola
    Biochemistry and Developmental Biology, Institute of Biomedicine, P O Box 63, Haartmaninkatu 8, University of Helsinki, FIN 00014, Finland
    J Am Soc Nephrol 22:274-84. 2011
    ..In summary, Vsnl1 marks ureteric bud tips in embryonic kidneys, and its mosaic pattern demonstrates a heterogeneity of cell types that may be critical for normal ureteric branching...
  28. pmc GLI3 repressor controls functional development of the mouse ureter
    Jason E Cain
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Invest 121:1199-206. 2011
    ..Together, these data demonstrate that Hh signaling controls Kit and Hcn3 expression and ureter peristalsis...
  29. pmc Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos
    Alexandre Gonçalves
    Developmental Genetics, Department of Biomedicine, University of Basel Medical Faculty, Basel, Switzerland
    PLoS ONE 6:e19370. 2011
    ..Therefore, we investigated whether BMP7 in turn also participates in inhibiting ureteric bud outgrowth during the initiation of metanephric kidney development...
  30. pmc Renal collecting system growth and function depend upon embryonic γ1 laminin expression
    Dong Hua Yang
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Development 138:4535-44. 2011
    ..mRNA levels for fibroblast growth factor 2 (FGF2) and mediators of the GDNF/RET and WNT11 signaling pathway were also decreased...
  31. doi The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney
    Regina Willecke
    Max Delbrueck Center for Molecular Medicine MDC, Robert Roessle Strasse 10, 13125 Berlin, Germany
    Dev Biol 360:310-7. 2011
    ..Apparently, Shp2 mediates not only GDNF/Ret but also signaling by other receptor tyrosine kinases in branching morphogenesis of the embryonic kidney...
  32. pmc Conditional expression of Wnt9b in Six2-positive cells disrupts stomach and kidney function
    Susan M Kiefer
    Department of Internal Medicine, Saint Louis University, St Louis, Missouri, United States of America
    PLoS ONE 7:e43098. 2012
    ..These results demonstrate that expression of Wnt9b in Six2-positive cells disrupts cell fate decisions in the kidney and the gastrointestinal tract...
  33. ncbi Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney
    L T Patterson
    Division of Nephrology and Hypertension, The Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 128:2153-61. 2001
    ....
  34. ncbi Expression patterns of Wnt genes in mouse gut development
    H Lickert
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108, Freiburg, Germany
    Mech Dev 105:181-4. 2001
    ..b>Wnt11 is expressed in the epithelium of esophagus and colon, but also in mesenchymal cells of the stomach...
  35. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
    ..To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2...
  36. pmc WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development
    Kanako Hayashi
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
    Biol Reprod 84:308-19. 2011
    ..to diethylstilbestrol (DES) on Wnt and Fzd gene expression in the mouse uterus as well as the biological role of Wnt11 in postnatal mouse uterine development and function...
  37. pmc Wnt signaling in the murine diastema
    Thantrira Porntaveetus
    Department of Craniofacial Development, Dental Institute, King s College London, Guy s Hospital, London, UK
    Eur J Orthod 34:518-24. 2012
    ..The expression of Wnt6 and Wnt11 was found in both tissues...
  38. pmc FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique
    Guangping Tai
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK
    Biol Open 2:416-23. 2013
    ..We demonstrate the utility of the screen by using it to identify the FAK-Src-pathway signalling as being important for collecting duct development, specifically for the cell proliferation on which this development depends...
  39. doi Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo
    Stephane D Vincent
    Department of Developmental and Stem Cell Biology, Institut Pasteur, CNRS URA 2578, Paris, France
    Hum Mol Genet 23:5087-101. 2014
    ..Our results identify PRDM1 as a potential modifier of phenotypic severity in TBX1 haploinsufficient DiGeorge syndrome patients. ..
  40. doi Enrichment of cardiac differentiation by a large starting number of embryonic stem cells in embryoid bodies is mediated by the Wnt11-JNK pathway
    Ming Chen
    Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China
    Biotechnol Lett 37:475-81. 2015
    ..that groups of EBs with different starting numbers of ESCs had differential gene expression patterns for Wnt5a and Wnt11. Wnt11 significantly increased the percentage of beating EBs by up-regulating the expression of the cardiac-..
  41. pmc Mapping the dynamic expression of Wnt11 and the lineage contribution of Wnt11-expressing cells during early mouse development
    Tanvi Sinha
    Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, United States
    Dev Biol 398:177-92. 2015
    ..In Xenopus and zebrafish, PCP signaling is activated by non-canonical Wnts such as Wnt11, and detailed understanding of Wnt11 expression has provided important clues on when, where and how PCP may be ..
  42. doi Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT
    Joseph A Bisson
    Division of Endocrinology and Metabolism, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Dev Biol 398:80-96. 2015
    ..We recently reported that two non-canonical Wnt ligands, Wnt5a and Wnt11, act cooperatively to attenuate canonical Wnt signaling that would otherwise disrupt the SHF...
  43. pmc Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression
    Robert A H van de Ven
    Department of Pathology, UMC Utrecht, 3584 CX Utrecht, The Netherlands
    Dis Model Mech 8:373-84. 2015
    ..mouse ILC cells, and identified 29 candidate target genes, including the established Kaiso target Wnt11. Our data indicate that anchorage-independent upregulation of Wnt11 in ILC cells is controlled by nuclear p120 ..
  44. pmc Stromally expressed β-catenin modulates Wnt9b signaling in the ureteric epithelium
    Felix J Boivin
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    PLoS ONE 10:e0120347. 2015
    ..We propose that β-catenin in the renal stroma modulates a genetic program in ureteric epithelium that is required for the induction of nephron progenitors. ..
  45. pmc Endodermal Wnt signaling is required for tracheal cartilage formation
    John Snowball
    The Perinatal Institute Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Medical Center Research Foundation, USA
    Dev Biol 405:56-70. 2015
    ..In conclusion, Wnt ligands produced by the tracheal epithelium pattern the tracheal mesenchyme via modulation of gene expression and cell proliferation required for proper tracheal cartilage and smooth muscle differentiation. ..
  46. doi Dlx5 and Dlx6 control uterine adenogenesis during post-natal maturation: possible consequences for endometriosis
    Brice Bellessort
    Evolution des Regulations Endocriniennes, CNRS UMR 7221, Muséum Nationale d Histoire Naturelle, Paris 75005, France
    Hum Mol Genet 25:97-108. 2016
    ..Given their importance for female reproduction, DLX5 and DLX6 must be regarded as interesting targets for future clinical research. ..
  47. doi The canonical Wnt signaling pathway is not involved in renal cyst development in the kidneys of inv mutant mice
    Noriyuki Sugiyama
    Department of Anatomy and Developmental Biology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Kidney Int 79:957-65. 2011
    ..Thus, our results do not support the hypothesis that canonical Wnt signaling causes renal cyst development in these mice...
  48. pmc A secreted BMP antagonist, Cer1, fine tunes the spatial organization of the ureteric bud tree during mouse kidney development
    Lijun Chi
    Laboratory of Developmental Biology, Department of Medical Biochemistry and Molecular Biology, Center for Cell Matrix Research, Institute of Biomedicine Oulu, Biocenter Oulu, University of Oulu, Oulu, Finland
    PLoS ONE 6:e27676. 2011
    ..Cer1 gain of function is associated with moderately elevated expression of Gdnf and Wnt11, which is also induced in the case of Cer1 deficiency, where Bmp4 expression is reduced, indicating the dependence ..
  49. pmc Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells
    Emma R Andersson
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Center of Developmental Biology for Regenerative Medicine, and Department of Cell and Molecular Biology, Karolinska Institute, Stockholm 171 77, Sweden
    Proc Natl Acad Sci U S A 110:E602-10. 2013
    ....
  50. pmc Paracrine effect of Wnt11-overexpressing mesenchymal stem cells on ischemic injury
    Shi Zuo
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    Stem Cells Dev 21:598-608. 2012
    Our previous studies have suggested that transduction of Wnt11 directly increases bone marrow-derived mesenchymal stem cells (MSCs) differentiation into cardiac phenotypes...
  51. pmc Activation of Wnt11 by transforming growth factor-β drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells
    Peng Zhang
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 287:21290-302. 2012
    ..a screen for genes directly activated by TGF-β, we found that components of the Wnt signaling pathway, especially Wnt11, were targets of activation by TGF-β and Smad3 in primary renal epithelial cells...
  52. pmc Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling
    Steven Hoseong Yang
    Department of Dermatology and Comprehensive Cancer Center, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:1130-5. 2008
    ....
  53. pmc Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development
    Hong Xiang Liu
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Dev Biol 361:39-56. 2012
    ....
  54. doi Efficient cardiomyogenic differentiation of bone marrow mesenchymal stromal cells by combination of Wnt11 and bone morphogenetic protein 2
    Zhifeng Zhang
    Department of Biology, Xuzhou Medical College, Xuzhou 221002, Jiangsu, China
    Exp Biol Med (Maywood) 237:768-76. 2012
    b>Wnt11 and bone morphogenetic protein 2 (BMP-2) are key signaling factors for stem cell differentiation into functional cardiomyocytes (CMs)...
  55. pmc UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice
    Keiko Ainoya
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mol Cell Biol 32:2312-22. 2012
    ....
  56. pmc Wingless homolog Wnt11 suppresses bacterial invasion and inflammation in intestinal epithelial cells
    Xingyin Liu
    Gastroenterology and Hepatology Division, Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Am J Physiol Gastrointest Liver Physiol 301:G992-G1003. 2011
    b>Wnt11 plays an essential role in gastrointestinal epithelial proliferation, and previous investigations have focused on development and immune responses...
  57. pmc Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys
    Abdul Soofi
    Dept of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 365:241-50. 2012
    ..These experiments provide new insight into the role of Pax2 protein levels in determining correct renal architecture and cell fate. These new Pax2 alleles are valuable genetic reagents for in vivo studies of urogenital development...
  58. pmc Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme
    Minoti Hiremath
    Department of Biological Sciences, Boise State University, Boise, ID 83725, USA
    Development 139:4239-49. 2012
    ..Therefore, we conclude that a mesenchymal, canonical Wnt pathway mediates the PTHrP-dependent specification of the mammary mesenchyme...
  59. ncbi Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a
    M C Adamson
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    Genomics 24:9-13. 1994
    ..Using a PCR-based approach, we have isolated two novel members of the murine Wnt gene family, Wnt11 and Wnt12...
  60. ncbi The molecular basis of embryonic kidney development
    M S Lechner
    Howard Hughes Medical Institute and Department of Pathology, University of Michigan, Ann Arbor 48109 0650, USA
    Mech Dev 62:105-20. 1997
    ..Although the factors involved are far from completely known a rough framework of a molecular cascade which governs embryonic kidney development is beginning to emerge...
  61. pmc Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase
    S L Bullock
    Laboratory of Mammalian Development, Medical Research Council MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Genes Dev 12:1894-906. 1998
    ..These data provide the first genetic evidence that the regulated synthesis of differentially glycosylated proteoglycans can affect morphogenesis during vertebrate development...
  62. ncbi The Wnts
    J J Loureiro
    Department of Biology, University of North Carolina at Chapel Hill, 27599 3280, USA
    Curr Biol 9:R4. 1999
  63. ncbi Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes
    P D Burbelo
    Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Gene 232:209-15. 1999
    ..The high level of PAK-1 and PAK-3 kinase expression in the mouse brain and spinal cord suggests a potentially important role for these kinases in the control of the cellular architecture and/or signaling in the central nervous system...
  64. ncbi Molecular genetic studies of Wnt signaling in the mouse
    M Uusitalo
    Faculties of Science and Medicine, University of Oulu, Oulu, 90570, Finland
    Exp Cell Res 253:336-48. 1999
  65. ncbi Characterization of an amphioxus wnt gene, AmphiWnt11, with possible roles in myogenesis and tail outgrowth
    M Schubert
    Genesis 27:1-5. 2000
    ..A phylogenetic analysis of all known full-length Wnt11 sequences indicates that a gene duplication occurred at the base of the vertebrate Wnt11 clade...
  66. ncbi Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis
    S Grisaru
    Division of Nephrology, Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Dev Biol 231:31-46. 2001
    ..We propose that GPC3 modulates the actions of stimulatory and inhibitory growth factors during branching morphogenesis...
  67. ncbi Epaxial-adaxial-hypaxial regionalisation of the vertebrate somite: evidence for a somitic organiser and a mirror-image duplication
    R Spörle
    Institute of Mammalian Genetics, GSF Research Center for Environment and Health, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Dev Genes Evol 211:198-217. 2001
    ....
  68. ncbi Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney
    Catherine A Schnabel
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5342, USA
    Dev Biol 254:262-76. 2003
    ..Taken together, these data establish a role for Pbx1 in mesenchymal-epithelial signaling and demonstrate that Pbx1 is an essential regulator of mesenchymal function during renal morphogenesis...
  69. ncbi Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea
    Alain Dabdoub
    Section on Developmental Neuroscience, NIDCD, National Institutes of Health, Rockville, MD 20850, USA
    Development 130:2375-84. 2003
    ..We propose that Wnt signaling across the region of developing outer hair cells gives rise to planar polarity in the mammalian cochlea...
  70. ncbi Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    Chen Leng Cai
    Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Dev Cell 5:877-89. 2003
    ..Our results have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells...
  71. ncbi Expression and estradiol regulation of Wnt genes in the mouse blastocyst identify a candidate pathway for embryo-maternal signaling at implantation
    Othman A Mohamed
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada H3A 1A1
    Biol Reprod 71:417-24. 2004
    ..Additional Wnt genes are newly expressed following development to blastocyst. Unexpectedly, Wnt5a and Wnt11 are expressed in embryos that undergo the morula-to-blastocyst transition in vivo, but only weakly or not at all ..
  72. ncbi Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin
    Si Wan Kim
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, The University of Texas Graduate School of Biomedical Science, Houston, Texas 77030, USA
    Nat Cell Biol 6:1212-20. 2004
    ..xWnt11, which contributes to the xKaiso knockdown phenotype as it is significantly rescued by dominant-negative Wnt11. We further demonstrate that xWnt11 is a direct gene target of xKaiso and that p120-catenin association relieves ..
  73. ncbi T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Development 132:2475-87. 2005
    ....
  74. ncbi Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney
    David Grote
    McGill Cancer Centre and Biochemistry Department, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    Development 133:53-61. 2006
    ..Together, these results define Gata3 as a key regulator of nephric duct morphogenesis and guidance in the pro/mesonephric kidney...
  75. pmc Wnt signaling induces epithelial differentiation during cutaneous wound healing
    Carrie Fathke
    Department of Surgery, University of Washington School of Medicine, Seattle, WA 98195, USA
    BMC Cell Biol 7:4. 2006
    ....
  76. ncbi Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production
    Mattias Ormestad
    Department of Cell and Molecular Biology, Goteborg University, Goteborg, Sweden
    Development 133:833-43. 2006
    ..Thus, Foxf proteins are mesenchymal factors that control epithelial proliferation and survival, and link hedgehog to Bmp and Wnt signaling...
  77. ncbi Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract
    Seungwoon Seo
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 332 PRB, 2220 Pierce Ave, Nashville, TN 37232 6300, USA
    Dev Biol 296:421-36. 2006
    ..Taken together, our results demonstrate that Foxc1 and Foxc2 play pivotal roles in the early processes of heart development, especially acting upstream of the Tbx1-FGF cascade during the morphogenesis of the OFT...
  78. ncbi The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression
    Tohru Kimura
    Department of Pathology, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Dev Biol 300:545-53. 2006
    ..Our results show that the suppression of Wnt/beta-catenin signaling is a prerequisite for the normal development of PGCs...
  79. ncbi Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney
    Melina Narlis
    McGill Cancer Centre and Biochemistry Department, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    J Am Soc Nephrol 18:1121-9. 2007
    ..At the ureter tips, the expression of Wnt11, a target of glial cell-derived neurotrophic factor-Ret signaling, is significantly reduced, whereas the ..
  80. pmc Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
    Lizhu Lin
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:9313-8. 2007
    ..of genes required for pharyngeal arch, outflow tract, and/or atrial septal morphogenesis, including Tbx2, Tbx3, Wnt11, Shh, and Pitx2...
  81. doi Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development
    Jong Min Lee
    Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Yonsei University, Seoul, Republic of Korea
    Dev Biol 314:341-50. 2008
    ..We examined the expression patterns of Wnt11 and Fgfr1b - which are believed to be key factors in convergent extension - in mouse palate development...
  82. doi Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex
    Shinji Yamamoto
    Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Dev Cell 15:23-36. 2008
    ..These results suggest that Cthrc1 is a Wnt cofactor protein that selectively activates the Wnt/PCP pathway by stabilizing ligand-receptor interaction...
  83. pmc Tbx3 is required for outflow tract development
    Karim Mesbah
    Developmental Biology Institute of Marseilles Luminy, France
    Circ Res 103:743-50. 2008
    ....
  84. doi Lack of Gata3 results in conotruncal heart anomalies in mouse
    Raivo Raid
    Department of Developmental Biology, University of Tartu, Tartu, Estonia
    Mech Dev 126:80-9. 2009
    ..The short outflow tract and insufficient rotation of truncus arteriosus during looping stages might be the main reasons underlying these malformations...
  85. pmc Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration
    Xiuping Yu
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Prostate 69:249-62. 2009
    ..Although stabilizing mutations in APC and beta-Catenin are rare in primary prostate tumors, recent studies suggest that cytoplasmic/nuclear beta-Catenin is associated with advanced, metastatic, hormone-refractory prostate carcinoma...
  86. pmc Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2
    Michael S Friedman
    Thermogenesis Corporation, Rancho Cordova, California 95742, USA
    J Biol Chem 284:14117-25. 2009
    b>Wnt11 signals through both canonical (beta-catenin) and non-canonical pathways and is up-regulated during osteoblast differentiation and fracture healing. In these studies, we evaluated the role of Wnt11 during osteoblastogenesis...
  87. pmc Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction
    Yuhang Zhang
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Cell 17:49-61. 2009
    ..These data reveal a complex interplay and interdependence of Wnt/beta-catenin and EDA/EDAR/NF-kappaB signaling pathways in initiation and maintenance of primary hair follicle placodes...
  88. doi Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression
    Irina I Nagy
    Department of Medical Biochemistry and Molecular Biology, University of Oulu, 90014 Oulu, Finland
    Cardiovasc Res 85:100-9. 2010
    ..We have addressed the potential role of Wnt-11 in the control of early ventricular myocardium assembly...
  89. doi The murine Fgfrl1 receptor is essential for the development of the metanephric kidney
    Simon D Gerber
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    Dev Biol 335:106-19. 2009
    ..We also observed a loss of Pax2 positive nephron precursor cells and an increase of apoptosis in the cortical zone of the remnant kidney. Fgfrl1 is therefore essential for mesenchymal differentiation in the early steps of nephrogenesis...
  90. pmc Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia
    Sunder Sims-Lucas
    Rangos Research Center, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15201, USA
    Am J Physiol Renal Physiol 297:F1208-19. 2009
    ..However, Ret and Wnt11 (molecules critical for ureteric branching morphogenesis) mRNA levels were lower in mutants vs. controls...
  91. pmc Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11
    Yu Shik Hwang
    Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:16978-83. 2009
    ..In contrast, the increased expression of WNT11 enhanced cardiogenesis...
  92. doi vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis
    Ludmilla Lokmane
    UMR7622 CNRS Université Pierre et Marie Curie, 9 quai St Bernard Bat C, 75005 Paris, France
    Development 137:347-57. 2010
    ....
  93. pmc Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme
    Yukako Uchiyama
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 107:9240-5. 2010
    ..Thus, Kif26b is essential for kidney development because it regulates the adhesion of mesenchymal cells in contact with ureteric buds...
  94. pmc Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate
    Wei Liu
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Invest 120:3568-77. 2010
    ....
  95. pmc Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism
    Jun Wang
    Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, 77030, USA
    Dev Cell 19:903-12. 2010
    ..Our findings indicate that Bmp signaling directly regulates a miRNA-mediated effector mechanism that downregulates cardiac progenitor genes and enhances myocardial differentiation...
  96. pmc SOX9 controls epithelial branching by activating RET effector genes during kidney development
    Antoine Reginensi
    Inserm U636, F 06108 Nice, France
    Hum Mol Genet 20:1143-53. 2011
    ..Our results also explain the aetiology of kidney hypoplasia found in a proportion of CD patients...
  97. pmc Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis
    Xuguang Nie
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of NYU, New York, NY 10029, USA
    Dev Biol 352:141-51. 2011
    ..This study uncovers an essential function for Six1 in the MM as an upstream regulator of Grem1 in initiating branching morphogenesis...
  98. pmc Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney
    Xin Ye
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Development 138:1161-72. 2011
    ..lead to reduced ureteric bud growth and a reduction in kidney size, a phenotype previously reported for loss of Wnt11. In cell culture, Fz4 and Fz8 can mediate noncanonical signaling stimulated by Wnt11, but only Fz4 mediates Wnt11-..
  99. doi Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3
    Yasuaki Mohri
    Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Dev Dyn 240:1626-34. 2011
    ..We demonstrate here that Lgr4 has a novel function for maintaining the UB in an undifferentiated state...
  100. ncbi Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development
    J H Christiansen
    Centre for Molecular and Cellular Biology, University of Queensland, St Lucia, Australia
    Mech Dev 51:341-50. 1995
    ..Wnt-11 transcripts are also detected in limb bud mesenchyme from the time the bud is first visible. Wnt-12 is detected in the apical ectodermal ridge from 10.5 dpc. The implications of these expression patterns are discussed...
  101. ncbi Epithelial sodium channel genes Scnn1b and Scnn1g are closely linked on distal mouse chromosome 7
    D R Brooker
    Department of Medicine, University of Pennsylvania, Philadelphia 19104 6144, USA
    Genomics 29:784-6. 1995
    ..Scnn1b and Scnn1g were determined to be closely linked on distal mouse chromosome 7, showing no recombination with Zp2, whereas the gene for the alpha-subunit, Scnn1a, was confirmed to map to distal mouse chromosome 6...

Research Grants1

  1. Towards renal regeneration
    Melissa Little; Fiscal Year: 2004
    ..Human ES cell work will be performed using ES01, 02, 03, 04, 05 & 06 listed on the NIH ES cell line registry. ..