Wnt2

Summary

Gene Symbol: Wnt2
Description: wingless-type MMTV integration site family, member 2
Alias: 2610510E18Rik, Int1l1, Irp, Mirp, Wnt-2, Wnt2a, protein Wnt-2, INT-1-related protein, wingless-related MMTV integration site 2
Species: mouse

Top Publications

  1. ncbi Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies
    Hong Wang
    Carolina Cardiovascular Biology Center and Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 282:782-91. 2007
  2. ncbi Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis
    Julie Bayle
    Department of Medicine, Rheumatology Section, Boston University School of Medicine, Arthritis Center, Boston, Massachusetts 02118, USA
    J Invest Dermatol 128:871-81. 2008
  3. pmc beta-Catenin promotes respiratory progenitor identity in mouse foregut
    Kelley S Harris-Johnson
    Laboratory of Genetics and Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:16287-92. 2009
  4. ncbi Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis
    T Ishikawa
    Banyu Tsukuba Research Institute Merck, Tsukuba, Japan
    Development 128:25-33. 2001
  5. ncbi The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium
    Joel Weidenfeld
    Department of Medicine, Molecular Cardiology Research Center, and the Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:21061-70. 2002
  6. ncbi Fgf10 is essential for limb and lung formation
    K Sekine
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Nat Genet 21:138-41. 1999
  7. ncbi Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    C V Pepicelli
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1083-6. 1998
  8. doi Altered expression of Autism-associated genes in the brain of Fragile X mouse model
    Aiying Zhang
    Department of Genetics, Peking University Health Science Center, Beijing 100083, China
    Biochem Biophys Res Commun 379:920-3. 2009
  9. pmc Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut
    Ashley M Goss
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 17:290-8. 2009
  10. ncbi Targeted disruption of the Wnt2 gene results in placentation defects
    S J Monkley
    Centre for Molecular and Cellular Biology, University of Queensland, Australia
    Development 122:3343-53. 1996

Research Grants

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
  2. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
  3. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
  4. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
  5. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008

Scientific Experts

  • A Wodarz
  • Hong Fu
  • Alain Dabdoub
  • Tadashi Okubo
  • KLAUS KAESTNER
  • Edward E Morrisey
  • Yongjun Yin
  • Ashley M Goss
  • Ying Tian
  • Ethan David Cohen
  • Min Min Lu
  • David M Ornitz
  • Diane Zhou
  • Jifu Yang
  • Katsumi Fumoto
  • Ke K Zhang
  • John Snowball
  • Arianna Caprioli
  • Jinhua Lu
  • Brian G Hiester
  • Tien Peng
  • David R Rawnsley
  • Arnon Dias Jurberg
  • Hongyao Yu
  • Takeshi Onizuka
  • X M Zhang
  • Min Yu
  • Ripla Arora
  • Mayumi F Miller
  • Ita Costello
  • Nikos Sgantzis
  • Fenglei He
  • Bi Sen Ding
  • Hajime Takayasu
  • Kyle M Sousa
  • Hong Xing Wang
  • Christina M Alfieri
  • A P McMahon
  • Ying Zhang
  • Xiuping Yu
  • John J Lepore
  • Dennis R Warner
  • Keith D Salazar
  • Kelley S Harris-Johnson
  • Aiying Zhang
  • Lan Yi
  • Eric T Domyan
  • Xin Sun
  • Steven Hoseong Yang
  • Julie Bayle
  • Yuzhen Zhang
  • Hong Wang
  • Ambra A Zaghetto
  • Hisham Bazzi
  • Hiroko Habuchi
  • R Verani
  • Alexander Alexandrovich
  • Stijn P De Langhe
  • Sarah E Millar
  • Yoshifumi Yamaguchi
  • Esther Merki
  • Othman A Mohamed
  • Hisako Takigawa-Imamura
  • Daniel Dufort
  • Tomoyuki Kaneiwa
  • Kenta Sumiyama
  • Akira Kikuchi
  • Xiaohua Zhang
  • Menglan Xiang
  • Nathan Curry
  • Linglin Xie
  • Pablo Garcia-Pavia
  • Damian Heine Suñer
  • Jielin Liu
  • S Bellusci
  • Lun Zhou
  • Qin Wang
  • Hong Liu
  • Stryder M Meadows
  • Thomas J Yan
  • Lyndsay A Wylie
  • Manoj Ambalavanan
  • Debora Sinner
  • Alethia Villasenor
  • Courtney M Karner
  • David Barry
  • Thomas J Carroll
  • Marrit Hoekstra
  • Ondine Cleaver
  • Stephen Fu

Detail Information

Publications82

  1. ncbi Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies
    Hong Wang
    Carolina Cardiovascular Biology Center and Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 282:782-91. 2007
    Our recent gene expression profiling analyses demonstrated that Wnt2 is highly expressed in Flk1(+) cells, which serve as common progenitors of endothelial cells, blood cells, and mural cells...
  2. ncbi Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis
    Julie Bayle
    Department of Medicine, Rheumatology Section, Boston University School of Medicine, Arthritis Center, Boston, Massachusetts 02118, USA
    J Invest Dermatol 128:871-81. 2008
    ..Tsk skin showed increased mRNA levels of several genes involved in Wnt signaling, including Wnt2, Wnt9a, Wnt10b and Wnt11; Dapper homolog antagonist of beta-catenin (DACT1) and DACT2; Wnt-induced secreted protein ..
  3. pmc beta-Catenin promotes respiratory progenitor identity in mouse foregut
    Kelley S Harris-Johnson
    Laboratory of Genetics and Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:16287-92. 2009
    ..Our findings reveal an early role for beta-Catenin in the establishment of respiratory progenitors in mouse foregut endoderm...
  4. ncbi Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis
    T Ishikawa
    Banyu Tsukuba Research Institute Merck, Tsukuba, Japan
    Development 128:25-33. 2001
    ..5 days post coitum. Fzd5 specifically synergized with Wnt2, Wnt5a and Wnt10b in ectopic axis induction assays in Xenopus embryos...
  5. ncbi The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium
    Joel Weidenfeld
    Department of Medicine, Molecular Cardiology Research Center, and the Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:21061-70. 2002
    ..Together, these results suggest that WNT7b gene expression in the lung epithelium is regulated in a combinatorial fashion by TTF-1, GATA6, and Foxa2...
  6. ncbi Fgf10 is essential for limb and lung formation
    K Sekine
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Nat Genet 21:138-41. 1999
    ..Thus, we show here that Fgf10 serves as an essential regulator of lung and limb formation...
  7. ncbi Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    C V Pepicelli
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1083-6. 1998
    ..In addition, the transcription of several mesenchymally expressed downstream targets of Shh is abolished. These results highlight the importance of epithelially derived Shh in regulating branching morphogenesis of the lung...
  8. doi Altered expression of Autism-associated genes in the brain of Fragile X mouse model
    Aiying Zhang
    Department of Genetics, Peking University Health Science Center, Beijing 100083, China
    Biochem Biophys Res Commun 379:920-3. 2009
    ..Genet. 142 (2006) 40-51]. We have used real-time PCR to investigate changes in expression levels of three genes: WNT2, MECP2, and FMR1 in different brain regions of Fagile X mice and litter mate controls...
  9. pmc Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut
    Ashley M Goss
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 17:290-8. 2009
    ..However, the molecular pathways specifying foregut endoderm progenitors are poorly understood. We show here that Wnt2/2b signaling is required to specify lung endoderm progenitors within the anterior foregut...
  10. ncbi Targeted disruption of the Wnt2 gene results in placentation defects
    S J Monkley
    Centre for Molecular and Cellular Biology, University of Queensland, Australia
    Development 122:3343-53. 1996
    ..Reported here for the first time is the expression of Wnt2 in the early heart field of 7.5-8...
  11. pmc Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development
    Ying Tian
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 18:275-87. 2010
    ..Here we show that Wnt2 is expressed specifically in the developing inflow tract mesoderm, which generates portions of the atria and atrio-..
  12. pmc Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression
    Ashley M Goss
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 356:541-52. 2011
    ..Here, we identify the Wnt2 ligand as a critical regulator of the earliest aspects of lung airway smooth muscle development...
  13. pmc Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation
    Brian G Hiester
    Department of Molecular, Cellular and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309, United States
    Mol Cell Neurosci 56:115-27. 2013
    ..Additionally, we show that BDNF regulates expression of Wnt2, and that Wnt2 is sufficient to promote cortical dendrite growth and dendritic spine formation...
  14. ncbi Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality
    Hiroko Habuchi
    Institute for Molecular Science of Medicine and Laboratory Animal Research Center, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
    J Biol Chem 282:15578-88. 2007
    ..mice revealed a marked reduction of GlcNAc(6SO(4)) and HexA-GlcNSO(3)(6SO(4)) levels and a reduced ability to bind Wnt2. Thus, despite the presence of three closely related 6-O-sulfotransferase genes in the mouse genome, HS6ST-1 is the ..
  15. pmc The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development
    David R Rawnsley
    Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 288:24429-40. 2013
    ..Whether ATOH8 modulates GATA-FOG function at other sites or in more subtle ways in mammals is not yet known. ..
  16. pmc Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor
    Tien Peng
    Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 500:589-92. 2013
    ..mesoderm progenitors (CPPs) within the posterior pole of the heart that are marked by the expression of Wnt2, Gli1 and Isl1. We show that CPPs arise from cardiac progenitors before lung development...
  17. pmc Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma
    Yongjun Yin
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 11:e1005242. 2015
    ..These studies identify an essential miRNA-FGF9 pathway for lung development and a non-cell autonomous signaling mechanism that contributes to the mesenchymal hyperplasia that is characteristic of Type I PPB. ..
  18. ncbi A new nomenclature for int-1 and related genes: the Wnt gene family
    R Nusse
    Cell 64:231. 1991
  19. pmc Endodermal Wnt signaling is required for tracheal cartilage formation
    John Snowball
    The Perinatal Institute Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Medical Center Research Foundation, USA
    Dev Biol 405:56-70. 2015
    ..In conclusion, Wnt ligands produced by the tracheal epithelium pattern the tracheal mesenchyme via modulation of gene expression and cell proliferation required for proper tracheal cartilage and smooth muscle differentiation. ..
  20. ncbi Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid
    R Verani
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 100:242-50. 2007
    ..These data suggest that induction of Dkk-1 and the ensuing inhibition of the canonical Wnt pathway is required for neural differentiation of ES cells...
  21. ncbi Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung
    Stijn P De Langhe
    Developmental Biology Program, Department of Surgery, USC Keck School of Medicine and the Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 277:316-31. 2005
    ..DKK1-induced morphogenetic defects can be mimicked by inhibition of FN and overcome by addition of exogenous FN, suggesting an involvement of FN in Wnt-regulated morphogenetic processes...
  22. doi Wnt4 is essential to normal mammalian lung development
    Arianna Caprioli
    Dept of Biology and Physical Sciences, Marymount Univ, 2807 N Glebe Rd, Arlington, VA 22207, USA
    Dev Biol 406:222-34. 2015
    ..In addition, we observe reduction of the important lung growth factors Fgf9, Fgf10, Sox9 and Wnt2 in the lung bud during early stages of organogenesis, as well as decreased tracheal expression of the progenitor ..
  23. pmc Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation
    Ke K Zhang
    Department of Pathology, School of Medicine and Health Sciences, ND INBRE Bioinformatics Core, University of North Dakota, Grand Forks, ND 58202, USA
    Hum Mol Genet 25:1140-51. 2016
    ..In summary, our study implicated a gene network involving Tbx5, Osr1 and Pcsk6 interaction in SHF for atrial septation, providing a molecular framework for understanding the role of Tbx5 in CHD ontogeny. ..
  24. doi Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition
    Katsumi Fumoto
    Departments of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita 565 0871, Japan
    Development 144:151-162. 2017
    ..These results suggest that Wnt signaling is required for bud formation by inducing apical constriction during the pseudoglandular stage, whereas loss of Wnt signaling is necessary for air sac formation in the canalicular-saccular stages...
  25. ncbi Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development
    B J Gavin
    Roche Institute of Molecular Biology, Hoffmann La Roche, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 4:2319-32. 1990
    ..All new Wnt family members are expressed in adult tissues, particularly in brain and lung. These data support the view that the Wnt-1/int-1 family constitutes a large family of signaling peptides with diverse roles in mouse development...
  26. ncbi Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts
    A Bafico
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Oncogene 16:2819-25. 1998
    ..These findings establish that both Wnt signaling and pattern of growth alterations differ from those of oncogenes which activate proliferative signaling pathways in NIH3T3 cells...
  27. ncbi Nucleotide sequence, chromosomal localization and developmental expression of the mouse int-1-related gene
    J A McMahon
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110
    Development 107:643-50. 1989
    cDNA clones encoding the murine int-1-related protein (m-irp) were isolated from an 8.5-day mouse embryo library...
  28. pmc Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless
    B J Wainwright
    Department of Biochemistry, St Mary s Hospital Medical School, London, UK
    EMBO J 7:1743-8. 1988
    ..This human int-1 related protein, int-1 and Dint-1 have diverse patterns of expression, but the inferred structural similarities suggest that some of the functional characteristics of these proteins may be shared...
  29. doi Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway
    Takeshi Onizuka
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    J Mol Cell Cardiol 52:650-9. 2012
    ..We found that Wnt2 was strongly up-regulated during cardiomyocyte differentiation from ES cells...
  30. pmc The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation
    Ita Costello
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Cell Biol 13:1084-91. 2011
    ..Collectively, our experiments demonstrate that Eomes governs discrete context-dependent transcriptional programmes that sequentially specify cardiac and definitive endoderm progenitors during gastrulation...
  31. pmc RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis
    Min Yu
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 487:510-3. 2012
    ..from an endogenous mouse pancreatic cancer model and subjected CTCs to single-molecule RNA sequencing, identifying Wnt2 as a candidate gene enriched in CTCs...
  32. pmc Deletion of STK40 protein in mice causes respiratory failure and death at birth
    Hongyao Yu
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai JiaoTong University School of Medicine, 225 South Chongqing Road, Shanghai 200025, China
    J Biol Chem 288:5342-52. 2013
    ..STK40 may associate with RCN2 to activate ERK/MAPK signaling and control the expression of multiple key regulators of lung development...
  33. pmc A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta
    Jinhua Lu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People s Republic of China
    PLoS Biol 11:e1001536. 2013
    ..These data indicate that Gcm1 and Fzd5 function in an evolutionary conserved positive feedback loop that regulates trophoblast differentiation and sites of chorionic branching morphogenesis...
  34. pmc Wnt ligands signal in a cooperative manner to promote foregut organogenesis
    Mayumi F Miller
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:15348-53. 2012
    ..We show that two Wnt ligands, Wnt2 and Wnt7b, cooperatively induce Wnt signaling without affecting the stabilization of the Wnt canonical effector β-..
  35. pmc Multiple roles and interactions of Tbx4 and Tbx5 in development of the respiratory system
    Ripla Arora
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS Genet 8:e1002866. 2012
    ..Concordant with this defect, the expression of mesenchymal markers Wnt2 and Fgf10, as well as Fgf10 target genes Bmp4 and Spry2, in the epithelium is downregulated...
  36. pmc Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling
    Steven Hoseong Yang
    Department of Dermatology and Comprehensive Cancer Center, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:1130-5. 2008
    ....
  37. doi Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos
    Arnon Dias Jurberg
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Dev Cell 25:451-62. 2013
    ..Our findings provide a perspective to understand the evolution of the vertebrate body plan...
  38. ncbi Molecular cloning and localization to chromosome 6 of mouse INT1L1 gene
    A M Chan
    Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Somat Cell Mol Genet 15:555-62. 1989
    The human INT1L1 gene, which exhibits homology to the protooncogene INT1 is very closely linked to the MET gene and cystic fibrosis locus on human chromosome 7...
  39. pmc Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts
    Keith D Salazar
    Department of Molecular Biomedical Sciences, North Carolina State University, 4700 Hillsborough St, Raleigh, NC 27606, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1002-11. 2009
    ..In addition, anti-Wnt1 and anti-Wnt2 antibodies attenuated MSC-CM-induced proliferation, and increased expression of Wnt7b was identified...
  40. ncbi Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis
    S Bellusci
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2175, USA
    Development 122:1693-702. 1996
    ..A model is proposed for the role of BMP4 and other signalling molecules in embryonic lung morphogenesis...
  41. pmc Wnt signaling in heart valve development and osteogenic gene induction
    Christina M Alfieri
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Medical Center, ML 7020, 240 Albert Sabin Way, Cincinnati, OH 45229, USA
    Dev Biol 338:127-35. 2010
    ..Multiple Wnt ligands and pathway genes are differentially expressed during heart valve development. At E12.5, Wnt2 is expressed in cushion mesenchyme, whereas Wnt4 and Wnt9b are predominant in overlying endothelial cells. At E17...
  42. pmc Wnt2 regulates progenitor proliferation in the developing ventral midbrain
    Kyle M Sousa
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vag 1, A1 2, 17177 Stockholm, Sweden
    J Biol Chem 285:7246-53. 2010
    ..In this study, we perform the first purification and signaling analysis of Wnt2 and define the function of Wnt2 in ventral midbrain precursor cultures, as well as in Wnt2-null mice in vivo...
  43. pmc WNT2 regulates DNA synthesis in mouse granulosa cells through beta-catenin
    Hong Xing Wang
    Departments of Physiology and Pharmacology, Obstetrics and Gynecology, and Pediatrics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    Biol Reprod 82:865-75. 2010
    ..Therefore, the objective of this study was to investigate the regulation and function of WNT2 signaling in mouse granulosa cells...
  44. ncbi An anchored molecular map of mouse chromosome 6 with an analysis of interference
    P O Davies
    Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France
    Mamm Genome 6:738-40. 1995
  45. doi Embryonic Wnt gene expression in the nitrofen-induced hypoplastic lung using 3-dimensional imaging
    Hajime Takayasu
    The Children s Research Centre, Our Lady s Children s Hospital, Dublin, Ireland
    J Pediatr Surg 45:2129-35. 2010
    ..We have previously reported that pulmonary gene expression of Wnt2 and Wnt7b is downregulated on day 15 of gestation in the nitrofen-induced congenital diaphragmatic hernia (CDH) ..
  46. pmc Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
    Bi Sen Ding
    Howard Hughes Medical Institute, Ansary Stem Cell Institute, and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Nature 468:310-5. 2010
    ..owing to diminished expression of LSEC-derived angiocrine factors, including hepatocyte growth factor (HGF) and Wnt2. Notably, in in vitro co-cultures, VEGFR2-Id1 activation in LSECs stimulates hepatocyte proliferation...
  47. pmc Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression
    Fenglei He
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Dev Biol 350:511-9. 2011
    ..Collectively, our results demonstrate an essential role for Wnt/β-catenin signaling in the epithelial component at the step of palate fusion during palate development by controlling the expression of Tgfβ3 in the MEE...
  48. doi HuR controls lung branching morphogenesis and mesenchymal FGF networks
    Nikos Sgantzis
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, 16672 Vari, Greece
    Dev Biol 354:267-79. 2011
    ..Our data reveals HuR as the first RBP identified to play a dominant role in lung development and as a key post-transcriptional regulator of networks guiding tissue remodeling during branching morphogenesis...
  49. ncbi Localization and quantification of Wnt-2 gene expression in mouse mammary development
    T A Bühler
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    Dev Biol 155:87-96. 1993
    ..Furthermore, they suggest that Wnt-2, as well as several other family members, may play a role in pattern formation during early mammary gland development...
  50. pmc Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development
    Yongjun Yin
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 138:3169-77. 2011
    ..During pseudoglandular stages of lung development, Wnt2a and Wnt7b are the canonical WNT ligands that activate mesenchymal WNT/β-catenin signaling, whereas FGF9 is the ..
  51. ncbi A genomic clone containing a telomere array maps near the centromere of mouse chromosome 6
    C H Yen
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, New York State Department of Health, Buffalo 14263, USA
    Mamm Genome 6:96-102. 1995
    ..A variety of sequence changes from the consensus hexamer suggests that this array has been removed for a long time from evolutionary pressures to retain the TTAGGG sequence...
  52. pmc Expression of Wnts in the developing murine secondary palate
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, Kentucky 40292, USA
    Int J Dev Biol 53:1105-12. 2009
    ..The expression of 5 Wnt family members was found to be temporally regulated. Moreover, these Wnts had unique spatio-temporal patterns of expression which suggested possible roles in palatal ontogeny...
  53. ncbi The little (lit) mutation cosegregates with the growth hormone releasing factor receptor on mouse chromosome 6
    S C Chua
    Laboratory of Human Behavior and Metabolism, Rockefeller University, New York, New York 10021
    Mamm Genome 4:555-9. 1993
    ..Low level of message could reflect a primary molecular defect or be due to secondary hypoplasia of somatotropes.(ABSTRACT TRUNCATED AT 250 WORDS)..
  54. ncbi Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds
    B A Parr
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Nutley, NJ 07110
    Development 119:247-61. 1993
    ..We discuss the significance of these patterns of restricted and partially overlapping domains of expression with respect to the putative function of Wnt signalling in early CNS and limb development...
  55. ncbi Wnt-3a regulates somite and tailbud formation in the mouse embryo
    S Takada
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 8:174-89. 1994
    ..We suggest that dysmorphology is secondary to the mesodermal and axial defects and that dorsal patterning of the CNS may be regulated by inductive signals arising from surface ectoderm...
  56. ncbi Wnt2 is a direct downstream target of GATA6 during early cardiogenesis
    Alexander Alexandrovich
    Cardiovascular Division, King s College London, London SE5 9PJ, UK
    Mech Dev 123:297-311. 2006
    ..We show that early cardiac expression of one of these genes, Wnt2, mirrors that of GATA6 in vitro and in vivo...
  57. pmc Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes
    R E Ellsworth
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:1172-7. 2000
    ..Furthermore, the generated sequence reveals the precise architecture of genes residing near CFTR/Cftr, including one known gene (WNT2/Wnt2) and two previously unknown genes that immediately flank CFTR/Cftr.
  58. ncbi Molecular genetic studies of Wnt signaling in the mouse
    M Uusitalo
    Faculties of Science and Medicine, University of Oulu, Oulu, 90570, Finland
    Exp Cell Res 253:336-48. 1999
  59. ncbi Expression patterns of Wnt genes in mouse gut development
    H Lickert
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108, Freiburg, Germany
    Mech Dev 105:181-4. 2001
    ..Here we describe the identification of Wnt genes, Wnt2a, 4, 5a, 5b, 6 and 11, expressed in mouse embryonic gut development...
  60. ncbi Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node
    X M Zhang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Cell 105:781-92. 2001
    ..Further, we demonstrate an absolute requirement for Hedgehog signaling in sclerotomal development and a role in cardiac morphogenesis.[Dedicated to Rosa Beddington, a pioneer in mammalian embryology]...
  61. ncbi Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node
    X M Zhang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Cell 106:781-92. 2001
    ..Further, we demonstrate an absolute requirement for Hedgehog signaling in sclerotomal development and a role in cardiac morphogenesis...
  62. ncbi Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis
    S Reddy
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mech Dev 107:69-82. 2001
    ..These results identify candidates for several key follicular signals and suggest that WNT and SHH signaling pathways interact to regulate hair follicle morphogenesis...
  63. ncbi Extracellular modulation of the Hedgehog, Wnt and TGF-beta signalling pathways during embryonic development
    J Capdevila
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Opin Genet Dev 9:427-33. 1999
    ....
  64. ncbi Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea
    Alain Dabdoub
    Section on Developmental Neuroscience, NIDCD, National Institutes of Health, Rockville, MD 20850, USA
    Development 130:2375-84. 2003
    ..We propose that Wnt signaling across the region of developing outer hair cells gives rise to planar polarity in the mammalian cochlea...
  65. ncbi Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina
    Hong Liu
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Dev Dyn 227:323-34. 2003
    ....
  66. ncbi Expression and estradiol regulation of Wnt genes in the mouse blastocyst identify a candidate pathway for embryo-maternal signaling at implantation
    Othman A Mohamed
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada H3A 1A1
    Biol Reprod 71:417-24. 2004
    ....
  67. pmc Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Biol 3:11. 2004
    ..The full range of effects of this pathway, which includes the transcription factor Lef1, has not been explored, however...
  68. ncbi Mechanisms of Wnt signaling in development
    A Wodarz
    Institut fur Genetik, Universitat Dusseldorf, Germany
    Annu Rev Cell Dev Biol 14:59-88. 1998
    ..Here we review recent data that have started to unravel the mechanisms of Wnt signaling...
  69. ncbi Gene trap screening as an effective approach for identification of Wnt-responsive genes in the mouse embryo
    Yoshifumi Yamaguchi
    Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Myodaiji, Okazaki, Aichi, Japan
    Dev Dyn 233:484-95. 2005
    ..These results indicate that the gene trap is an effective method for systematic identification of Wnt-responsive genes during embryogenesis...
  70. pmc Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation
    Esther Merki
    Institute of Molecular Medicine, University of California, San Diego, CA 92093, USA
    Proc Natl Acad Sci U S A 102:18455-60. 2005
    ....
  71. ncbi Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
    S Bellusci
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 124:53-63. 1997
    ..No difference could be observed between transgenic and control lungs in either the level or distribution of Bmp4, Wnt2 and Fgf7 RNA. By contrast, Ptc is clearly upregulated in the transgenic lung...
  72. ncbi The Wnts
    J J Loureiro
    Department of Biology, University of North Carolina at Chapel Hill, 27599 3280, USA
    Curr Biol 9:R4. 1999
  73. ncbi The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis
    Hisham Bazzi
    Department of Genetics and Development, Columbia University, New York, NY, USA
    Dev Biol 305:498-507. 2007
    ..We propose that Dkk4 acts in a negative feedback loop to attenuate canonical Wnt signaling, and may facilitate a switch to the non-canonical Wnt planar cell polarity (PCP) pathway that is involved in cell movements during morphogenesis...
  74. pmc An FGF-WNT gene regulatory network controls lung mesenchyme development
    Yongjun Yin
    Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 319:426-36. 2008
    ..Together, both FGF and WNT signaling pathways function to sustain mesenchymal growth and coordinate epithelial morphogenesis during the pseudoglandular stage of lung development...
  75. pmc A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration
    Yuzhen Zhang
    Department of Medicine, University of Pennsylvania, 956 BRB II III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 40:862-70. 2008
    ..Together, these data demonstrate that Gata6-regulated Wnt signaling controls the balance between progenitor expansion and epithelial differentiation required for both lung development and regeneration...
  76. pmc Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration
    Xiuping Yu
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Prostate 69:249-62. 2009
    ..Although stabilizing mutations in APC and beta-Catenin are rare in primary prostate tumors, recent studies suggest that cytoplasmic/nuclear beta-Catenin is associated with advanced, metastatic, hormone-refractory prostate carcinoma...
  77. pmc Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects
    Ying Zhang
    Department of Cell and Developmental Biology, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 325:82-93. 2009
    ..These results demonstrate an important role for PlexinD1 in embryonic and adult vasculature...
  78. ncbi The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation
    K H Kaestner
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104 6145, USA
    Genes Dev 11:1583-95. 1997
    ....
  79. ncbi Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart morphogenesis
    B Jaspard
    INSERM U441, Avenue du Haut Leveque, 33 600, Pessac, France
    Mech Dev 90:263-7. 2000
    ..Immunoprecipitation experiments demonstrates that FrzA binds to mWnt-8 in cell culture experiments...
  80. pmc Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung
    Lan Yi
    Laboratory of Genetics, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Dev Dyn 238:123-37. 2009
    ..This model also represents our findings on the genetic relationship between FGF9 and sonic hedgehog (SHH) in the establishment of airway SMC pattern...
  81. pmc Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections
    Ambra A Zaghetto
    Dulbecco Telethon Institute Consiglio Nazionale delle Ricerche Institute for Biomedical Technologies Milano, 20090 Segrate, Italy
    J Neurosci 27:9757-68. 2007
    ..These data reveal a novel function for Wnt signaling in the establishment of periphery-CNS olfactory connections and highlight a complex interplay between cells of different embryonic origin for ORN axon connectivity...

Research Grants5

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  2. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  3. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  4. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  5. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..