Wnt3

Summary

Gene Symbol: Wnt3
Description: wingless-type MMTV integration site family, member 3
Alias: Int-4, Wnt-3, proto-oncogene Wnt-3, proto-oncogene Int-4, proto-oncogene protein Wnt-3, wingless-related MMTV integration site 3
Species: mouse

Top Publications

  1. ncbi A new nomenclature for int-1 and related genes: the Wnt gene family
    R Nusse
    Cell 64:231. 1991
  2. ncbi The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
    A P McMahon
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Cell 62:1073-85. 1990
  3. ncbi Requirement for Wnt3 in vertebrate axis formation
    P Liu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 22:361-5. 1999
  4. ncbi Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning
    Cindy C Lu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 273:149-59. 2004
  5. ncbi Disruption of early proximodistal patterning and AVE formation in Apc mutants
    Claire Chazaud
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Development 133:3379-87. 2006
  6. ncbi Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres
    P C Salinas
    Howard Hughes Medical Institute, Stanford Medical School, Stanford University, CA 94305
    Mech Dev 39:151-60. 1992
  7. ncbi Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube
    H Roelink
    Howard Hughes Medical Institute, Beckman Center, Stanford University, California 94305
    Genes Dev 5:381-8. 1991
  8. ncbi Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries
    A Bulfone
    Department of Psychiatry, University of California, San Francisco 94143 0984
    J Neurosci 13:3155-72. 1993
  9. ncbi Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cells
    P C Salinas
    Department of Developmental Biology, Stanford University, CA 94305 5428
    Development 120:1277-86. 1994
  10. ncbi Nodal signalling in the epiblast patterns the early mouse embryo
    J Brennan
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 411:965-9. 2001

Scientific Experts

Detail Information

Publications122 found, 100 shown here

  1. ncbi A new nomenclature for int-1 and related genes: the Wnt gene family
    R Nusse
    Cell 64:231. 1991
  2. ncbi The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
    A P McMahon
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Cell 62:1073-85. 1990
    ..Homozygotes are born, but die within 24 hr. Thus the normal role of Wnt-1 is in determination or subsequent development of a specific region of the central nervous system...
  3. ncbi Requirement for Wnt3 in vertebrate axis formation
    P Liu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 22:361-5. 1999
    ..Here we show that Wnt3 is expressed before gastrulation in the proximal epiblast of the egg cylinder, then is restricted to the posterior ..
  4. ncbi Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning
    Cindy C Lu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 273:149-59. 2004
    ....
  5. ncbi Disruption of early proximodistal patterning and AVE formation in Apc mutants
    Claire Chazaud
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Development 133:3379-87. 2006
    ..In addition, we found that nuclear beta-catenin and other molecular markers are asymmetrically expressed by 4.5 days...
  6. ncbi Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres
    P C Salinas
    Howard Hughes Medical Institute, Stanford Medical School, Stanford University, CA 94305
    Mech Dev 39:151-60. 1992
    ..The continued expression of these genes in the adult mouse brain suggests a distinct role in the mature CNS...
  7. ncbi Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube
    H Roelink
    Howard Hughes Medical Institute, Beckman Center, Stanford University, California 94305
    Genes Dev 5:381-8. 1991
    ..Characteristic expression patterns of these two closely related genes suggest that Wnt-3 and Wnt-3A play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube...
  8. ncbi Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries
    A Bulfone
    Department of Psychiatry, University of California, San Francisco 94143 0984
    J Neurosci 13:3155-72. 1993
    ..These findings are consistent with neuromeric theories of forebrain development, and based upon them we suggest a model for forebrain segmentation...
  9. ncbi Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cells
    P C Salinas
    Department of Developmental Biology, Stanford University, CA 94305 5428
    Development 120:1277-86. 1994
    ..Our results show that Wnt-3 expression in Purkinje cells is modulated by their presynaptic granule cells at the time of neuronal maturation...
  10. ncbi Nodal signalling in the epiblast patterns the early mouse embryo
    J Brennan
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 411:965-9. 2001
    ..Our experiments show that proximal-distal and subsequent anterior-posterior polarity of the pregastrulation embryo result from reciprocal cell-cell interactions between the epiblast and the two extra-embryonic tissues...
  11. ncbi Primitive streak formation in mice is preceded by localized activation of Brachyury and Wnt3
    Jaime A Rivera-Perez
    Department of Genetics, Campus Box 7264, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Dev Biol 288:363-71. 2005
    ..Here, we examine the proposed correlation between the expression of Brachyury and Wnt3, two genes reported as expressed radially in the proximal epiblast, with the movements of proximal anterior ..
  12. ncbi Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching
    Andrew S Rakeman
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Development 133:3075-83. 2006
    ..Thus, the Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo...
  13. doi Dkk1 and Wnt3 interact to control head morphogenesis in the mouse
    Samara L Lewis
    Children s Medical Research Institute, University of Sydney, Wentworthville, New South Wales, NSW 2145, Australia
    Development 135:1791-801. 2008
    ..The juxtaposition of the expression domains of Dkk1 and Wnt3 is suggestive of an antagonist-agonist interaction...
  14. pmc Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity
    Hirotaka Tao
    Division for Morphogenesis, National Institute for Basic Biology, Myodaiji, Okazaki, Aichi 444 8585, Japan
    Proc Natl Acad Sci U S A 106:14426-31. 2009
    ..Our results demonstrate a role for mpk1 in AB polarity formation rather than expected role as a PCP gene...
  15. doi Wnt-3a and Wnt-3 differently stimulate proliferation and neurogenesis of spinal neural precursors and promote neurite outgrowth by canonical signaling
    Monica D David
    Laboratori d Investigacio, Hospital Universitari Arnau de Vilanova, Departament de Ciencies Mediques Basiques, IRBLleida University of Lleida, Lleida, Spain
    J Neurosci Res 88:3011-23. 2010
    ..These findings may be of therapeutic interest for the treatment of neurodegenerative diseases and nerve injury...
  16. ncbi Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds
    B A Parr
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Nutley, NJ 07110
    Development 119:247-61. 1993
    ..We discuss the significance of these patterns of restricted and partially overlapping domains of expression with respect to the putative function of Wnt signalling in early CNS and limb development...
  17. ncbi Genetic mapping of the gene for androgen-binding protein/sex hormone-binding globulin to mouse chromosome 11
    D R Joseph
    Department of Pediatrics, University of North Carolina, Chapel Hill
    Cytogenet Cell Genet 56:122-4. 1991
    ..The recent finding that ABP-SHBG is found throughout the rat brain raises the possibility that one of these mutations may be due to a defect in Shbg...
  18. pmc Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain
    H Roelink
    Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam
    Proc Natl Acad Sci U S A 87:4519-23. 1990
    ..The transcriptional unit of the Wnt-3 gene spans approximately 55 kb, with a first intron of 36 kb. The deduced amino acid sequence of the Wnt-3 protein is 47% identical to the int-1/Wnt-1 gene product...
  19. ncbi Chromosome engineering in mice
    R Ramirez-Solis
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 378:720-4. 1995
    ..The availability of mice with defined regions of segmental haploidy will allow their use in genetic screens and enable accurate models of human 'chromosomal' diseases to be generated...
  20. pmc Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10
    R S Yeung
    Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111
    Proc Natl Acad Sci U S A 90:8038-42. 1993
    ..Our result suggested that the human homolog of the RC gene may reside on human chromosome 16, not known to be altered commonly in human RC...
  21. ncbi The gene for C10, a member of the beta-chemokine family, is located on mouse chromosome 11 and contains a novel second exon not found in other chemokines
    M S Berger
    Hematology Oncology Division, Hospital of the University of Pennsylvania, Philadelphia 19104
    DNA Cell Biol 12:839-47. 1993
    ....
  22. ncbi Distribution of the mammalian Stat gene family in mouse chromosomes
    N G Copeland
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Genomics 29:225-8. 1995
    ..The data suggest that the family has arisen via a tandem duplication of the ancestral locus, followed by dispersion of the linked loci to different mouse chromosomes...
  23. ncbi Molecular cloning and chromosomal mapping of the mouse gene encoding cyclin-dependent kinase 5 regulatory subunit p35
    T Ohshima
    Developmental and Metabolic Neurology Branch, National Institutes of Health, Bethesda, Maryland, 20892 4326, USA
    Genomics 35:372-5. 1996
    ..The mouse Cdk5r transcript was detected only in the brain by Northern blot analysis. Mouse Cdk5r was mapped to a position on mouse chromosome 11...
  24. ncbi Visceral endoderm mediates forebrain development by suppressing posteriorizing signals
    C Kimura
    Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2 2 1, Kumamoto, 860 0811, Japan
    Dev Biol 225:304-21. 2000
    ..These results suggest that distal visceral endoderm cells move to the future anterior side to generate a prospective forebrain territory indirectly, by preventing posteriorizing signals...
  25. ncbi Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway
    Eric Hay
    Proskelia Pharmaceuticals, 102 route de Noisy, 93230 Romainville, France
    J Biol Chem 280:13616-23. 2005
    ..As a consequence, beta-catenin is no longer bound to Axin or phosphorylated by glycogen synthase kinase-3, resulting in TCF-1 activation...
  26. ncbi The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4
    Nadav Ben-Haim
    Ecole Polytechnique Fédérale de Lausanne EPFL ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Dev Cell 11:313-23. 2006
    ..In return, Bmp4 induces Wnt3, which amplifies Nodal expression in the epiblast and mediates induction of mesoderm...
  27. ncbi Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid
    R Verani
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 100:242-50. 2007
    ..These data suggest that induction of Dkk-1 and the ensuing inhibition of the canonical Wnt pathway is required for neural differentiation of ES cells...
  28. pmc An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling
    Peyman Björklund
    Department of Surgical Sciences, Uppsala University, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
    PLoS Med 4:e328. 2007
    ..Mechanisms that may account for this activation have not been identified, except for a few cases of beta-catenin (CTNNB1) stabilizing mutation in pHPT tumors...
  29. pmc Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation
    Joaquim Egea
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    Genes Dev 22:3349-62. 2008
    ..We propose that this novel function cooperates with the signaling activities of the AVE to restrict EMT and mesoderm induction to the posterior epiblast...
  30. pmc Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis
    Richard Daneman
    Stanford University School of Medicine, Department of Developmental Biology, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:641-6. 2009
    ..progenitor cells in distinct locations throughout the CNS, including Wnt7a and Wnt7b in ventral regions and Wnt1, Wnt3, Wnt3a, and Wnt4 in dorsal regions...
  31. doi Craniofacial malformation in R-spondin2 knockout mice
    Wakako Yamada
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 381:453-8. 2009
    ..These findings indicate that Rspo2 regulates midfacial, limb, and lung morphogenesis during development through the Wnt/beta-catenin signaling...
  32. pmc Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program
    Shinichi Miyagawa
    Institute of Molecular Embryology and Genetics, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto 860 0811, Japan
    Development 136:3969-78. 2009
    ..Our results provide new insights into the integration of growth factor signaling in the appendicular developmental programs that regulate external genitalia development...
  33. pmc Differential activity of Wnt/beta-catenin signaling in the embryonic mouse thalamus
    Krista K Bluske
    Department of Neuroscience, and Graduate Program in Neuroscience, Minneapolis, Minnesota 55455, USA
    Dev Dyn 238:3297-309. 2009
    ..Analysis of mice with enhanced or reduced Shh signal showed that Axin2 expression is similar to controls. These results suggest that differential Wnt signaling may play a role in patterning the thalamus independent of Shh signaling...
  34. pmc Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo
    Michael Buchert
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia
    PLoS Genet 6:e1000816. 2010
    ..Together, the present genotype-phenotype analysis suggests tissue-specific response levels for the Wnt/beta-catenin pathway that regulate both physiological and pathophysiological conditions...
  35. pmc Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo
    Shigeto Miura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Dev Biol 341:246-54. 2010
    ..5 restores expression patterns of Dkk1 and Cer1. These data indicate that BMP signaling in the epiblast induces Wnt3 and Wnt3a expression to maintain WNT signaling in the VE, resulting in downregulation of Dkk1 to establish the ..
  36. doi The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells
    Luis C Fernandez-Diaz
    IFOM, FIRC Institute of Molecular Oncology Foundation, IFOM IEO Campus, Via Adamello 16, Milan, Italy
    Development 137:3393-403. 2010
    ..Despite this early lethal phenotype, Prep1 is not essential for ES cell establishment. A differential embryonic expression pattern underscores the unique function of Prep1 within the Meis-Prep family...
  37. doi Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis
    Masahiro Okamoto
    Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology, Central 4, 1 1 4 Higashi, Tsukuba, 305 8562, Japan
    FASEB J 25:3570-82. 2011
    ..Adult hippocampal neurogenesis is unique in that astrocytes secreting Wnt3 promote NSC differentiation in a paracrine manner...
  38. doi Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells
    Henner F Farin
    Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Centre Utrecht, Utrecht, The Netherlands
    Gastroenterology 143:1518-1529.e7. 2012
    ..Paneth cells support stem cells by secreting Wnt, but little is known about the exact sources and primary functions of individual Wnt family members...
  39. doi Porcn-dependent Wnt signaling is not required prior to mouse gastrulation
    Steffen Biechele
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, ON M5G 1X8, Canada
    Development 140:2961-71. 2013
    ..Our studies highlight the importance of Wnt3 and Wnt7b for embryonic and placental development but suggest that endogenous Porcn-dependent Wnt secretion does ..
  40. doi A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants
    Shinya Aramaki
    Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Dev Cell 27:516-29. 2013
    ..germ cells (PGCs), the precursors for spermatozoa and oocytes, are induced in pluripotent epiblast by BMP4 and WNT3, yet the underlying mechanism remains unclear...
  41. doi Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural stem cell specification into oligodendrocytes and glutamatergic neurons
    Kasum Azim
    Brain Research Institute, University of Zürich ETHZ, Zurich, Switzerland
    Stem Cells 32:1301-12. 2014
    ..These results demonstrate a role for Wnt/β-catenin signaling within the dorsal microdomain of the postnatal SVZ, in regulating the genesis of glutamatergic neurons and OLs...
  42. pmc Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast
    Marcela Guzman-Ayala
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, 35 Medical Center Way, University of California, San Francisco, CA 94143, USA Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, 35 Medical Center Way, University of California, San Francisco, CA 94143, USA
    Development 142:118-27. 2015
    ..Thus, the RNA output by both Pol I and II is reduced in Chd1(-/-) cells. Our data indicate that Chd1 promotes a globally elevated transcriptional output required to sustain the distinctly rapid growth of the mouse epiblast. ..
  43. pmc Extra-embryonic Wnt3 regulates the establishment of the primitive streak in mice
    Yeonsoo Yoon
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Dev Biol 403:80-8. 2015
    ..Here we show that absence of Wnt3 in the posterior visceral endoderm leads to delayed formation of the primitive streak and that interplay between ..
  44. pmc Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia
    Bon Kyoung Koo
    Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 112:7548-50. 2015
    ..growing adenomas containing LGR5(+) (leucine-rich repeat-containing G-protein coupled receptor 5) stem cells and Wnt3-producing Paneth cells. We now show that removal of Paneth cells by Math1 mutation inhibits RZ(-/-) tumor formation...
  45. doi Visualization of a short-range Wnt gradient in the intestinal stem-cell niche
    Henner F Farin
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences KNAW and University Medical Center Utrecht, 3584CT Utrecht, The Netherlands
    Nature 530:340-3. 2016
    ..b>Wnt3 is produced specifically by Paneth cells. Here we have generated an epitope-tagged, functional Wnt3 knock-in allele...
  46. ncbi Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice
    T F Lane
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 9:2712-22. 1995
    ..In addition, increased transcription of mammary Brca1 during pregnancy might contribute, in part, to the reduced cancer risk associated with exposure to pregnancy and lactation...
  47. ncbi The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium
    Joel Weidenfeld
    Department of Medicine, Molecular Cardiology Research Center, and the Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:21061-70. 2002
    ..Together, these results suggest that WNT7b gene expression in the lung epithelium is regulated in a combinatorial fashion by TTF-1, GATA6, and Foxa2...
  48. pmc Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex
    Mélanie Béland
    Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec, Canada H2W 1R7
    Mol Cell Biol 24:5028-38. 2004
    ..Further data suggest that Cdx-high-mobility group box interactions might be involved in a number of additional pathways...
  49. doi Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo
    Nikolas Uez
    Helmholtz Center Munich, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, Munich, Neuherberg, Germany
    Genesis 46:463-77. 2008
    ..This observation was supported through genetic interaction with beta-catenin mutants, since compound heterozygous mutants recapitulated the defects of Wnt3a mutants in posterior development...
  50. doi Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos
    Steffen Biechele
    Department of Molecular Genetics, University of Toronto, ON, Canada
    Dev Biol 355:275-85. 2011
    ..cells with wildtype embryos fail to complete gastrulation in vivo, but remain in an epiblast-like state, similar to Wnt3 and Gpr177/Wls mutants...
  51. ncbi Mapping of the mouse 86-kDa heat-shock protein expressed gene (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4, 9, and 11
    S K Moore
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 10:1019-29. 1991
    ..An HSP86-related locus specific to NFS/N and C58/J mice, designated Hsp86-ps3, was mapped on Chromosome 9. Also, an HSP86-related locus that was unique to NFS/N mice, designated Hsp86-ps4, was mapped to Chromosome 4...
  52. pmc A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human
    A M Buchberg
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genetics 122:153-61. 1989
    ....
  53. ncbi Sequence and localization of a novel FK506-binding protein to mouse chromosome 11
    S L Simek
    Biological Carcinogenesis and Development Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland
    Genomics 18:407-9. 1993
    ..We have localized the FKBPRP gene to mouse Chromosome 11, and crosses of different murine strains provided the gene order centromere--FKBPRP-Int-4-Pkca-Es-3...
  54. ncbi Localization of three genes expressed in retina on mouse chromosome 11
    C A Kozak
    National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    Mamm Genome 6:142-4. 1995
  55. ncbi Chromosomal assignment of the heparin-binding cytokine genes MDK and PTN in mouse and man
    B O'HARA
    Molecular Biology Research Section, American Cyanamid Company, Pearl River, NY
    Cytogenet Cell Genet 69:40-3. 1995
    ..A pseudogene of Mdk was mapped to mouse Chromosome 11. The closely related human gene PTN was mapped to a separate location on human chromosome region 7q22-->qter...
  56. ncbi Gene structure and chromosomal localization of the mouse NMDA receptor channel subunits
    M Nagasawa
    Department of Neuropharmacology, Niigata University, Japan
    Brain Res Mol Brain Res 36:1-11. 1996
    ..Each of these genes mapped to a single chromosome location. The mapping results assigned the five loci to five different mouse autosomes, indicating that they have become well dispersed among mouse chromosomes...
  57. ncbi Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21
    I Bergstein
    Strang Cornell Cancer Research Laboratory, Cornell University Medical College, New York, New York 10021, USA
    Genomics 46:450-8. 1997
    ..We show that human WNT14 maps to chromosome 1 and that WNT15 maps distal to BRCA1 on chromosome 17q21, where it lies within 125 kb of another WNT family member, WNT3.
  58. pmc Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11
    P Liu
    Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 150:1155-68. 1998
    ..A duplication corresponding to one of these two deficiencies was able to rescue its haplolethality...
  59. ncbi Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord
    A Mansouri
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, 37077, Gottingen, Germany
    Mech Dev 78:171-8. 1998
    ..Our findings reveal two distinct regulatory pathways for spinal cord neurogenesis, only one of which is dependent on Pax3/7 and 6...
  60. ncbi WNT signaling in the control of hair growth and structure
    S E Millar
    Howard Hughes Medical Institute, Stanford University, Stanford, California, 94305 5428, USA
    Dev Biol 207:133-49. 1999
    ..We demonstrate that the proto-oncogene Wnt3, which encodes a secreted paracrine signaling molecule, is expressed in developing and mature hair follicles and ..
  61. ncbi Engineering a mouse balancer chromosome
    B Zheng
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 22:375-8. 1999
    ..The chromosome features a 24-centiMorgan (cM) inversion between Trp53 (also known as p53) and Wnt3 on mouse chromosome 11 that is recessive lethal and dominantly marked with a K14-Agouti transgene...
  62. ncbi Extracellular modulation of the Hedgehog, Wnt and TGF-beta signalling pathways during embryonic development
    J Capdevila
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Opin Genet Dev 9:427-33. 1999
    ....
  63. ncbi The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family
    K Tanaka
    Graduate Program for Regulation of Biological Signals, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    Eur J Biochem 267:4300-11. 2000
    ..These results demonstrate that the porc gene family encodes the multitransmembrane ER proteins, which are evolutionarily well conserved and involved in processing the Wnt family...
  64. ncbi Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity
    S J Kinder
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Int J Dev Biol 45:347-55. 2001
    ..of the expression pattern of genes associated with the posterior germ layer tissues and the primitive streak (T, Wnt3 and Fgf8) and anterior endoderm (Cer1 and Sox17) revealed that the A-P axis of mutant embryos remains aligned with ..
  65. ncbi The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo
    Dominic P Norris
    Department of Molecular and Cellular Biology, Harvard University, The Biological Laboratories, Cambridge, MA 02138, USA
    Development 129:3455-68. 2002
    ..The feedback loop is thus essential for maintenance of Nodal signals that selectively regulate target gene expression in a temporally and spatially controlled fashion in the mouse embryo...
  66. ncbi Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation
    Mahua Mukhopadhyay
    Department of Anatomy, University of Wisconsin Madison Medical School, Madison, WI 53706, USA
    Development 130:495-505. 2003
    ..The expression of several Wnt inhibitors is curtailed in the mutant, suggesting that Wnt pathways may be involved in axial patterning regulated by Ldb1...
  67. ncbi Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity
    Jen Chih Hsieh
    Department of Biochemistry and Cell Biology, Center for Developmental Genetics, State University of New York, Stony Brook, Stony Brook, NY 11794, USA
    Cell 112:355-67. 2003
    ..However, phenotypic differences between mesd-deficient and wnt3(-)(/)(-) embryos suggest that MESD may function on related members of the low-density lipoprotein receptor (LDLR) ..
  68. pmc Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb
    Natalia Soshnikova
    Max Delbrück Centrum for Molecular Medicine, Robert Rossle Strasse 10, 13125Berlin, Germany
    Genes Dev 17:1963-8. 2003
    ..Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/beta-catenin and BMP receptor signaling...
  69. ncbi Over- and ectopic expression of Wnt3 causes progressive loss of ameloblasts in postnatal mouse incisor teeth
    S E Millar
    Department of Dermatology and Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Connect Tissue Res 44:124-9. 2003
    ..WNT intercellular signaling molecules have been implicated in the regulation of tooth development, and the Wnt3 gene shows specific expression in the enamel knot at the cap stage...
  70. pmc Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling
    Elizabeth J Robertson
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Philos Trans R Soc Lond B Biol Sci 358:1351-7; discussion 1357. 2003
    ....
  71. ncbi A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo
    Q Tian Wang
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 6:133-44. 2004
    ..Overall, these data provide a detailed temporal profile of gene expression that reveals the richness of signaling processes in early mammalian development...
  72. ncbi Expression and estradiol regulation of Wnt genes in the mouse blastocyst identify a candidate pathway for embryo-maternal signaling at implantation
    Othman A Mohamed
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada H3A 1A1
    Biol Reprod 71:417-24. 2004
    ....
  73. ncbi A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British ColumbiaV6T 1Z3, Canada
    Birth Defects Res A Clin Mol Teratol 70:509-18. 2004
    ..Our previous studies mapped two loci: clf1 on Chr11 and clf2 on Chr13--with a strong genetic maternal effect on the level of risk. Here we test the hypothesis that CL(P) is digenic and identify candidate genes for clf1 and clf2...
  74. pmc A gene(s) for all-trans-retinoic acid-induced forelimb defects mapped and confirmed to murine chromosome 11
    Grace S Lee
    Molecular Toxicology Interdepartmental Program, UCLA School of Public Health, Los Angeles, California 90095, USA
    Genetics 170:345-53. 2005
    ..The human syntenic region of this locus has been previously linked to Meckel syndrome; the phenotype includes postaxial polydactyly, an ectopic digital defect hypothesized to be induced by a common molecular pathway with ectrodactyly...
  75. ncbi Activation of canonical Wnt pathway promotes proliferation of retinal stem cells derived from adult mouse ciliary margin
    Toshihiro Inoue
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto City, Japan
    Stem Cells 24:95-104. 2006
    ..A combination of Wnt and FGF signaling may provide a therapeutic strategy for in vitro expansion or in vivo activation of adult retinal stem cells...
  76. ncbi BMP signalling inhibits premature neural differentiation in the mouse embryo
    Aida Di-Gregorio
    Molecular Embryology Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK
    Development 134:3359-69. 2007
    ..Together, our results demonstrate that inhibition of BMP signalling has a central role during neural induction in mammals and suggest that FGFs do not act as neural inducers in the post-implantation mouse embryo...
  77. ncbi The derivatives of the Wnt3a lineage in the central nervous system
    Angeliki Louvi
    Department of Neurosurgery, Program on Neurogenetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 504:550-69. 2007
    ....
  78. pmc Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb
    Ju Suk Nam
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    Dev Biol 311:124-35. 2007
    ..Our findings strongly suggest that Rspo2 expression in the AER is required for AER maintenance likely by regulating Wnt/beta-catenin signaling...
  79. ncbi Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development
    Olov Andersson
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Dev Biol 311:500-11. 2007
    ....
  80. ncbi Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis
    Jeffery R Barrow
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 312:312-20. 2007
    ..We demonstrate that embryos lacking the signaling factor Wnt3 exhibit defects in this axial realignment...
  81. doi Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo
    Giovanna L Liguori
    IBB Institute for Biotechnology and Bioengineering, Centro de Biomedicina Molecular e Estrutural, Universidade do Algarve, Campus de Gambelas, 8005 135 Faro, Portugal
    Dev Biol 315:280-9. 2008
    ..This signaling activity drives A-P axis positioning. Our results provide evidence for the existence of Cripto-independent signaling mechanisms, by which Nodal controls axis specification in the early mouse embryo...
  82. pmc Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli
    Silvia A Purro
    Research Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 28:8644-54. 2008
    ..Consistently, short hairpin RNA knockdown of APC mimics Wnt3a function. Together, our findings define APC as a key Wnt signaling target in the regulation of microtubule growth direction...
  83. doi Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis
    Jungmook Lyu
    Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033
    Dev Cell 15:773-80. 2008
    ..is cleaved, permitting the intracellular C-terminal fragment of Ryk to translocate to the nucleus in response to Wnt3 stimulation...
  84. pmc Motor neurons with axial muscle projections specified by Wnt4/5 signaling
    Dritan Agalliu
    Howard Hughes Medical Institute, Kavli Institute for Brain Science, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 61:708-20. 2009
    ..Thus, two dorsoventral signaling pathways, mediated by Shh and Wnt4/5, are required to establish an early binary divergence in motor neuron columnar identity...
  85. pmc Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction
    Yuhang Zhang
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Cell 17:49-61. 2009
    ..These data reveal a complex interplay and interdependence of Wnt/beta-catenin and EDA/EDAR/NF-kappaB signaling pathways in initiation and maintenance of primary hair follicle placodes...
  86. doi Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells
    Marika Suomalainen
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Dyn 239:364-72. 2010
    ..We conclude that epithelial stem cells in the mouse incisors are not regulated directly by Wnt/beta-catenin signaling...
  87. pmc Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation
    Jiang Fu
    Department of Biomedical Genetics, Center for Oral Biology, James P Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:18598-603. 2009
    ..deficient Gpr177 exhibit defects in establishment of the body axis, a phenotype highly reminiscent to the loss of Wnt3. Although many different mammalian Wnt proteins are required for a wide range of developmental processes, the Wnt3 ..
  88. pmc Salmonella regulation of intestinal stem cells through the Wnt/beta-catenin pathway
    Xingyin Liu
    Department of Medicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    FEBS Lett 584:911-6. 2010
    ..The numbers of stem cells and proliferative cells increased in the intestine infected with Salmonella expressing AvrA. Our study provides insights into bacterial infection and stem cell maintenance...
  89. doi Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo
    Leonardo Morsut
    Department of Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy
    Development 137:2571-8. 2010
    ..This study unveils that intracellular negative control of Smad function by ectodermin/Tif1gamma is a crucial element in the cellular response to TGFbeta signals in mammalian tissues...
  90. pmc Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube
    Alisa S W Shum
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Dev Dyn 239:3192-203. 2010
    ..Taken together, these results support that the lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube...
  91. pmc Ectodermal Wnt/β-catenin signaling shapes the mouse face
    Bethany S Reid
    Department of Craniofacial Biology and Cell and Developmental Biology, University of Colorado Denver, 12801 East 17th Avenue, PO Box 6511, Aurora, CO 80045, USA
    Dev Biol 349:261-9. 2011
    ....
  92. pmc The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction
    Yong Ri Jin
    Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA
    Dev Biol 352:1-13. 2011
    ..Thus, our study identifies Rspo2 as a mesenchyme-derived factor that plays critical roles in regulating BA1 patterning and morphogenesis through ectodermal-mesenchymal interaction and a novel genetic factor for cleft palate...
  93. doi Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells
    Masato Tamura
    Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University, North 13, West 7, Sapporo 060 8586, Japan
    Int J Biochem Cell Biol 43:760-7. 2011
    ..These results show that canonical Wnt signaling regulates CXCL12 gene expression at the transcriptional level, and this is the first study linking chemokine expression to canonical Wnt signaling...
  94. pmc The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatus
    Congxing Lin
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 356:40-50. 2011
    ..We provide genetic evidence that disruption of either signaling pathway results in severe microglossia. Altogether, we demonstrate a dynamic role for Wnt-β-Catenin signaling in the development of the oral apparatus...
  95. pmc The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities
    Daniel Mesnard
    Ecole Polytechnique Fédérale de Lausanne EPFL SV ISREC, CH 1015 Lausanne, Switzerland
    Genes Dev 25:1871-80. 2011
    ..Adding cell-cell communication to the pleiotropic portfolio of these proteases provides a new framework to study proprotein processing also in other relevant contexts...
  96. pmc Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryo
    Shigeto Miura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Dev Dyn 240:2474-81. 2011
    ..These results suggest that HGS is critical to localize TAK1 to early endosome for transducing BMP signaling for proper development. Our data revealed a new mechanism to modify BMP signaling by Hgs during early mouse development...
  97. ncbi Isolation and characterization of MRF-1, a brain-derived DNA-binding protein with a capacity to regulate expression of myelin basic protein gene
    N S Haque
    Jefferson Institute of Molecular Medicine, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    J Biol Chem 269:31149-56. 1994
    ..8, 2.5, and 3.0 kilobases which are expressed in all tissues analyzed. The gene encoding MRF-1 is located on the distal half of mouse chromosome 11 in a region where the human homolog would be predicted to reside on human chromosome 17...
  98. ncbi Mapping of the Prkar1a gene to mouse chromosome 11
    J J Moskow
    Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philidelphia, Pennsylvania 19107, USA
    Mamm Genome 7:464-5. 1996
  99. ncbi Roles of Pax-6 in murine diencephalic development
    N Warren
    Department of Physiology, University Medical School, Edinburgh, UK
    Development 124:1573-82. 1997
    ..Pax-6 may also control some aspects of diencephalic differentiation, but its mutation in Small-eye mice does not preclude the development of a degree of diencephalic regionalization resembling that in normal mice...
  100. ncbi The Wnts
    J J Loureiro
    Department of Biology, University of North Carolina at Chapel Hill, 27599 3280, USA
    Curr Biol 9:R4. 1999
  101. ncbi Molecular genetic studies of Wnt signaling in the mouse
    M Uusitalo
    Faculties of Science and Medicine, University of Oulu, Oulu, 90570, Finland
    Exp Cell Res 253:336-48. 1999

Research Grants5

  1. WNT signals in developing and postnatal teeth
    Sarah Millar; Fiscal Year: 2008
    ..These experiments will help to place WNT signals in the network of regulatory factors that control tooth development, and will test the potential use of WNT activation in strategies for tooth or enamel regeneration. ..
  2. WNT SIGNALS IN SKIN AND HAIR DEVELOPMENT AND HAIR GROWTH
    Sarah E Millar; Fiscal Year: 2010
    ..abstract_text> ..
  3. Development of Choroid Plexus and the Blood-CSF Barrier
    Angeliki Louvi; Fiscal Year: 2006
    ....
  4. The role of cell polarity in vertebrate limb outgrowth
    Jeffery Barrow; Fiscal Year: 2007
    ..Furthermore he will examine the epistatic relationship between Fgf and Wnt/PCP signaling in regulating cell polarity. [unreadable] [unreadable] [unreadable]..
  5. Is non-canonical Wnt signaling required in cardiac neural crest cells?
    Ethan David Cohen; Fiscal Year: 2008
    ..This.information may lead to new detection or treatment strategies. [unreadable] [unreadable] [unreadable]..