Genomes and Genes
Gene Symbol: Wnt3
Description: wingless-type MMTV integration site family, member 3
Alias: Int-4, Wnt-3, proto-oncogene Wnt-3, proto-oncogene Int-4, proto-oncogene protein Wnt-3, wingless-related MMTV integration site 3
Publications122 found, 100 shown here
- A new nomenclature for int-1 and related genes: the Wnt gene familyR Nusse
Cell 64:231. 1991
- The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brainA P McMahon
Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
Cell 62:1073-85. 1990..Homozygotes are born, but die within 24 hr. Thus the normal role of Wnt-1 is in determination or subsequent development of a specific region of the central nervous system...
- Requirement for Wnt3 in vertebrate axis formationP Liu
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nat Genet 22:361-5. 1999..Here we show that Wnt3 is expressed before gastrulation in the proximal epiblast of the egg cylinder, then is restricted to the posterior ..
- Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterningCindy C Lu
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Dev Biol 273:149-59. 2004....
- Disruption of early proximodistal patterning and AVE formation in Apc mutantsClaire Chazaud
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
Development 133:3379-87. 2006..In addition, we found that nuclear beta-catenin and other molecular markers are asymmetrically expressed by 4.5 days...
- Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeresP C Salinas
Howard Hughes Medical Institute, Stanford Medical School, Stanford University, CA 94305
Mech Dev 39:151-60. 1992..The continued expression of these genes in the adult mouse brain suggests a distinct role in the mature CNS...
- Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tubeH Roelink
Howard Hughes Medical Institute, Beckman Center, Stanford University, California 94305
Genes Dev 5:381-8. 1991..Characteristic expression patterns of these two closely related genes suggest that Wnt-3 and Wnt-3A play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube...
- Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundariesA Bulfone
Department of Psychiatry, University of California, San Francisco 94143 0984
J Neurosci 13:3155-72. 1993..These findings are consistent with neuromeric theories of forebrain development, and based upon them we suggest a model for forebrain segmentation...
- Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cellsP C Salinas
Department of Developmental Biology, Stanford University, CA 94305 5428
Development 120:1277-86. 1994..Our results show that Wnt-3 expression in Purkinje cells is modulated by their presynaptic granule cells at the time of neuronal maturation...
- Nodal signalling in the epiblast patterns the early mouse embryoJ Brennan
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Nature 411:965-9. 2001..Our experiments show that proximal-distal and subsequent anterior-posterior polarity of the pregastrulation embryo result from reciprocal cell-cell interactions between the epiblast and the two extra-embryonic tissues...
- Primitive streak formation in mice is preceded by localized activation of Brachyury and Wnt3Jaime A Rivera-Perez
Department of Genetics, Campus Box 7264, University of North Carolina, Chapel Hill, NC 27599 7264, USA
Dev Biol 288:363-71. 2005..Here, we examine the proposed correlation between the expression of Brachyury and Wnt3, two genes reported as expressed radially in the proximal epiblast, with the movements of proximal anterior ..
- Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branchingAndrew S Rakeman
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Development 133:3075-83. 2006..Thus, the Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo...
- Dkk1 and Wnt3 interact to control head morphogenesis in the mouseSamara L Lewis
Children s Medical Research Institute, University of Sydney, Wentworthville, New South Wales, NSW 2145, Australia
Development 135:1791-801. 2008..The juxtaposition of the expression domains of Dkk1 and Wnt3 is suggestive of an antagonist-agonist interaction...
- Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarityHirotaka Tao
Division for Morphogenesis, National Institute for Basic Biology, Myodaiji, Okazaki, Aichi 444 8585, Japan
Proc Natl Acad Sci U S A 106:14426-31. 2009..Our results demonstrate a role for mpk1 in AB polarity formation rather than expected role as a PCP gene...
- Wnt-3a and Wnt-3 differently stimulate proliferation and neurogenesis of spinal neural precursors and promote neurite outgrowth by canonical signalingMonica D David
Laboratori d Investigacio, Hospital Universitari Arnau de Vilanova, Departament de Ciencies Mediques Basiques, IRBLleida University of Lleida, Lleida, Spain
J Neurosci Res 88:3011-23. 2010..These findings may be of therapeutic interest for the treatment of neurodegenerative diseases and nerve injury...
- Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb budsB A Parr
Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Nutley, NJ 07110
Development 119:247-61. 1993..We discuss the significance of these patterns of restricted and partially overlapping domains of expression with respect to the putative function of Wnt signalling in early CNS and limb development...
- Genetic mapping of the gene for androgen-binding protein/sex hormone-binding globulin to mouse chromosome 11D R Joseph
Department of Pediatrics, University of North Carolina, Chapel Hill
Cytogenet Cell Genet 56:122-4. 1991..The recent finding that ABP-SHBG is found throughout the rat brain raises the possibility that one of these mutations may be due to a defect in Shbg...
- Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brainH Roelink
Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam
Proc Natl Acad Sci U S A 87:4519-23. 1990..The transcriptional unit of the Wnt-3 gene spans approximately 55 kb, with a first intron of 36 kb. The deduced amino acid sequence of the Wnt-3 protein is 47% identical to the int-1/Wnt-1 gene product...
- Chromosome engineering in miceR Ramirez-Solis
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nature 378:720-4. 1995..The availability of mice with defined regions of segmental haploidy will allow their use in genetic screens and enable accurate models of human 'chromosomal' diseases to be generated...
- Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10R S Yeung
Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111
Proc Natl Acad Sci U S A 90:8038-42. 1993..Our result suggested that the human homolog of the RC gene may reside on human chromosome 16, not known to be altered commonly in human RC...
- The gene for C10, a member of the beta-chemokine family, is located on mouse chromosome 11 and contains a novel second exon not found in other chemokinesM S Berger
Hematology Oncology Division, Hospital of the University of Pennsylvania, Philadelphia 19104
DNA Cell Biol 12:839-47. 1993....
- Distribution of the mammalian Stat gene family in mouse chromosomesN G Copeland
Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
Genomics 29:225-8. 1995..The data suggest that the family has arisen via a tandem duplication of the ancestral locus, followed by dispersion of the linked loci to different mouse chromosomes...
- Molecular cloning and chromosomal mapping of the mouse gene encoding cyclin-dependent kinase 5 regulatory subunit p35T Ohshima
Developmental and Metabolic Neurology Branch, National Institutes of Health, Bethesda, Maryland, 20892 4326, USA
Genomics 35:372-5. 1996..The mouse Cdk5r transcript was detected only in the brain by Northern blot analysis. Mouse Cdk5r was mapped to a position on mouse chromosome 11...
- Visceral endoderm mediates forebrain development by suppressing posteriorizing signalsC Kimura
Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2 2 1, Kumamoto, 860 0811, Japan
Dev Biol 225:304-21. 2000..These results suggest that distal visceral endoderm cells move to the future anterior side to generate a prospective forebrain territory indirectly, by preventing posteriorizing signals...
- Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathwayEric Hay
Proskelia Pharmaceuticals, 102 route de Noisy, 93230 Romainville, France
J Biol Chem 280:13616-23. 2005..As a consequence, beta-catenin is no longer bound to Axin or phosphorylated by glycogen synthase kinase-3, resulting in TCF-1 activation...
- The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4Nadav Ben-Haim
Ecole Polytechnique Fédérale de Lausanne EPFL ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Dev Cell 11:313-23. 2006..In return, Bmp4 induces Wnt3, which amplifies Nodal expression in the epiblast and mediates induction of mesoderm...
- Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acidR Verani
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
J Neurochem 100:242-50. 2007..These data suggest that induction of Dkk-1 and the ensuing inhibition of the canonical Wnt pathway is required for neural differentiation of ES cells...
- An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signalingPeyman Björklund
Department of Surgical Sciences, Uppsala University, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
PLoS Med 4:e328. 2007..Mechanisms that may account for this activation have not been identified, except for a few cases of beta-catenin (CTNNB1) stabilizing mutation in pHPT tumors...
- Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiationJoaquim Egea
Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
Genes Dev 22:3349-62. 2008..We propose that this novel function cooperates with the signaling activities of the AVE to restrict EMT and mesoderm induction to the posterior epiblast...
- Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesisRichard Daneman
Stanford University School of Medicine, Department of Developmental Biology, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 106:641-6. 2009..progenitor cells in distinct locations throughout the CNS, including Wnt7a and Wnt7b in ventral regions and Wnt1, Wnt3, Wnt3a, and Wnt4 in dorsal regions...
- Craniofacial malformation in R-spondin2 knockout miceWakako Yamada
Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
Biochem Biophys Res Commun 381:453-8. 2009..These findings indicate that Rspo2 regulates midfacial, limb, and lung morphogenesis during development through the Wnt/beta-catenin signaling...
- Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular programShinichi Miyagawa
Institute of Molecular Embryology and Genetics, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto 860 0811, Japan
Development 136:3969-78. 2009..Our results provide new insights into the integration of growth factor signaling in the appendicular developmental programs that regulate external genitalia development...
- Differential activity of Wnt/beta-catenin signaling in the embryonic mouse thalamusKrista K Bluske
Department of Neuroscience, and Graduate Program in Neuroscience, Minneapolis, Minnesota 55455, USA
Dev Dyn 238:3297-309. 2009..Analysis of mice with enhanced or reduced Shh signal showed that Axin2 expression is similar to controls. These results suggest that differential Wnt signaling may play a role in patterning the thalamus independent of Shh signaling...
- Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivoMichael Buchert
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia
PLoS Genet 6:e1000816. 2010..Together, the present genotype-phenotype analysis suggests tissue-specific response levels for the Wnt/beta-catenin pathway that regulate both physiological and pathophysiological conditions...
- Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryoShigeto Miura
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Dev Biol 341:246-54. 2010..5 restores expression patterns of Dkk1 and Cer1. These data indicate that BMP signaling in the epiblast induces Wnt3 and Wnt3a expression to maintain WNT signaling in the VE, resulting in downregulation of Dkk1 to establish the ..
- The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cellsLuis C Fernandez-Diaz
IFOM, FIRC Institute of Molecular Oncology Foundation, IFOM IEO Campus, Via Adamello 16, Milan, Italy
Development 137:3393-403. 2010..Despite this early lethal phenotype, Prep1 is not essential for ES cell establishment. A differential embryonic expression pattern underscores the unique function of Prep1 within the Meis-Prep family...
- Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesisMasahiro Okamoto
Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology, Central 4, 1 1 4 Higashi, Tsukuba, 305 8562, Japan
FASEB J 25:3570-82. 2011..Adult hippocampal neurogenesis is unique in that astrocytes secreting Wnt3 promote NSC differentiation in a paracrine manner...
- Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cellsHenner F Farin
Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Centre Utrecht, Utrecht, The Netherlands
Gastroenterology 143:1518-1529.e7. 2012..Paneth cells support stem cells by secreting Wnt, but little is known about the exact sources and primary functions of individual Wnt family members...
- Porcn-dependent Wnt signaling is not required prior to mouse gastrulationSteffen Biechele
Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, ON M5G 1X8, Canada
Development 140:2961-71. 2013..Our studies highlight the importance of Wnt3 and Wnt7b for embryonic and placental development but suggest that endogenous Porcn-dependent Wnt secretion does ..
- A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinantsShinya Aramaki
Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
Dev Cell 27:516-29. 2013..germ cells (PGCs), the precursors for spermatozoa and oocytes, are induced in pluripotent epiblast by BMP4 and WNT3, yet the underlying mechanism remains unclear...
- Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural stem cell specification into oligodendrocytes and glutamatergic neuronsKasum Azim
Brain Research Institute, University of Zürich ETHZ, Zurich, Switzerland
Stem Cells 32:1301-12. 2014..These results demonstrate a role for Wnt/β-catenin signaling within the dorsal microdomain of the postnatal SVZ, in regulating the genesis of glutamatergic neurons and OLs...
- Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblastMarcela Guzman-Ayala
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, 35 Medical Center Way, University of California, San Francisco, CA 94143, USA Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, 35 Medical Center Way, University of California, San Francisco, CA 94143, USA
Development 142:118-27. 2015..Thus, the RNA output by both Pol I and II is reduced in Chd1(-/-) cells. Our data indicate that Chd1 promotes a globally elevated transcriptional output required to sustain the distinctly rapid growth of the mouse epiblast. ..
- Extra-embryonic Wnt3 regulates the establishment of the primitive streak in miceYeonsoo Yoon
Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Dev Biol 403:80-8. 2015..Here we show that absence of Wnt3 in the posterior visceral endoderm leads to delayed formation of the primitive streak and that interplay between ..
- Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasiaBon Kyoung Koo
Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
Proc Natl Acad Sci U S A 112:7548-50. 2015..growing adenomas containing LGR5(+) (leucine-rich repeat-containing G-protein coupled receptor 5) stem cells and Wnt3-producing Paneth cells. We now show that removal of Paneth cells by Math1 mutation inhibits RZ(-/-) tumor formation...
- Visualization of a short-range Wnt gradient in the intestinal stem-cell nicheHenner F Farin
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences KNAW and University Medical Center Utrecht, 3584CT Utrecht, The Netherlands
Nature 530:340-3. 2016..b>Wnt3 is produced specifically by Paneth cells. Here we have generated an epitope-tagged, functional Wnt3 knock-in allele...
- Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in miceT F Lane
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 9:2712-22. 1995..In addition, increased transcription of mammary Brca1 during pregnancy might contribute, in part, to the reduced cancer risk associated with exposure to pregnancy and lactation...
- The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epitheliumJoel Weidenfeld
Department of Medicine, Molecular Cardiology Research Center, and the Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 277:21061-70. 2002..Together, these results suggest that WNT7b gene expression in the lung epithelium is regulated in a combinatorial fashion by TTF-1, GATA6, and Foxa2...
- Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complexMélanie Béland
Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec, Canada H2W 1R7
Mol Cell Biol 24:5028-38. 2004..Further data suggest that Cdx-high-mobility group box interactions might be involved in a number of additional pathways...
- Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryoNikolas Uez
Helmholtz Center Munich, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, Munich, Neuherberg, Germany
Genesis 46:463-77. 2008..This observation was supported through genetic interaction with beta-catenin mutants, since compound heterozygous mutants recapitulated the defects of Wnt3a mutants in posterior development...
- Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryosSteffen Biechele
Department of Molecular Genetics, University of Toronto, ON, Canada
Dev Biol 355:275-85. 2011..cells with wildtype embryos fail to complete gastrulation in vivo, but remain in an epiblast-like state, similar to Wnt3 and Gpr177/Wls mutants...
- Mapping of the mouse 86-kDa heat-shock protein expressed gene (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4, 9, and 11S K Moore
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
Genomics 10:1019-29. 1991..An HSP86-related locus specific to NFS/N and C58/J mice, designated Hsp86-ps3, was mapped on Chromosome 9. Also, an HSP86-related locus that was unique to NFS/N mice, designated Hsp86-ps4, was mapped to Chromosome 4...
- A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and humanA M Buchberg
Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
Genetics 122:153-61. 1989....
- Sequence and localization of a novel FK506-binding protein to mouse chromosome 11S L Simek
Biological Carcinogenesis and Development Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland
Genomics 18:407-9. 1993..We have localized the FKBPRP gene to mouse Chromosome 11, and crosses of different murine strains provided the gene order centromere--FKBPRP-Int-4-Pkca-Es-3...
- Localization of three genes expressed in retina on mouse chromosome 11C A Kozak
National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
Mamm Genome 6:142-4. 1995
- Chromosomal assignment of the heparin-binding cytokine genes MDK and PTN in mouse and manB O'HARA
Molecular Biology Research Section, American Cyanamid Company, Pearl River, NY
Cytogenet Cell Genet 69:40-3. 1995..A pseudogene of Mdk was mapped to mouse Chromosome 11. The closely related human gene PTN was mapped to a separate location on human chromosome region 7q22-->qter...
- Gene structure and chromosomal localization of the mouse NMDA receptor channel subunitsM Nagasawa
Department of Neuropharmacology, Niigata University, Japan
Brain Res Mol Brain Res 36:1-11. 1996..Each of these genes mapped to a single chromosome location. The mapping results assigned the five loci to five different mouse autosomes, indicating that they have become well dispersed among mouse chromosomes...
- Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21I Bergstein
Strang Cornell Cancer Research Laboratory, Cornell University Medical College, New York, New York 10021, USA
Genomics 46:450-8. 1997..We show that human WNT14 maps to chromosome 1 and that WNT15 maps distal to BRCA1 on chromosome 17q21, where it lies within 125 kb of another WNT family member, WNT3.
- Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11P Liu
Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Genetics 150:1155-68. 1998..A duplication corresponding to one of these two deficiencies was able to rescue its haplolethality...
- Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cordA Mansouri
Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, 37077, Gottingen, Germany
Mech Dev 78:171-8. 1998..Our findings reveal two distinct regulatory pathways for spinal cord neurogenesis, only one of which is dependent on Pax3/7 and 6...
- WNT signaling in the control of hair growth and structureS E Millar
Howard Hughes Medical Institute, Stanford University, Stanford, California, 94305 5428, USA
Dev Biol 207:133-49. 1999..We demonstrate that the proto-oncogene Wnt3, which encodes a secreted paracrine signaling molecule, is expressed in developing and mature hair follicles and ..
- Engineering a mouse balancer chromosomeB Zheng
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nat Genet 22:375-8. 1999..The chromosome features a 24-centiMorgan (cM) inversion between Trp53 (also known as p53) and Wnt3 on mouse chromosome 11 that is recessive lethal and dominantly marked with a K14-Agouti transgene...
- Extracellular modulation of the Hedgehog, Wnt and TGF-beta signalling pathways during embryonic developmentJ Capdevila
The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Curr Opin Genet Dev 9:427-33. 1999....
- The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt familyK Tanaka
Graduate Program for Regulation of Biological Signals, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
Eur J Biochem 267:4300-11. 2000..These results demonstrate that the porc gene family encodes the multitransmembrane ER proteins, which are evolutionarily well conserved and involved in processing the Wnt family...
- Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activityS J Kinder
Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
Int J Dev Biol 45:347-55. 2001..of the expression pattern of genes associated with the posterior germ layer tissues and the primitive streak (T, Wnt3 and Fgf8) and anterior endoderm (Cer1 and Sox17) revealed that the A-P axis of mutant embryos remains aligned with ..
- The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryoDominic P Norris
Department of Molecular and Cellular Biology, Harvard University, The Biological Laboratories, Cambridge, MA 02138, USA
Development 129:3455-68. 2002..The feedback loop is thus essential for maintenance of Nodal signals that selectively regulate target gene expression in a temporally and spatially controlled fashion in the mouse embryo...
- Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulationMahua Mukhopadhyay
Department of Anatomy, University of Wisconsin Madison Medical School, Madison, WI 53706, USA
Development 130:495-505. 2003..The expression of several Wnt inhibitors is curtailed in the mutant, suggesting that Wnt pathways may be involved in axial patterning regulated by Ldb1...
- Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarityJen Chih Hsieh
Department of Biochemistry and Cell Biology, Center for Developmental Genetics, State University of New York, Stony Brook, Stony Brook, NY 11794, USA
Cell 112:355-67. 2003..However, phenotypic differences between mesd-deficient and wnt3(-)(/)(-) embryos suggest that MESD may function on related members of the low-density lipoprotein receptor (LDLR) ..
- Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limbNatalia Soshnikova
Max Delbrück Centrum for Molecular Medicine, Robert Rossle Strasse 10, 13125Berlin, Germany
Genes Dev 17:1963-8. 2003..Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/beta-catenin and BMP receptor signaling...
- Over- and ectopic expression of Wnt3 causes progressive loss of ameloblasts in postnatal mouse incisor teethS E Millar
Department of Dermatology and Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Connect Tissue Res 44:124-9. 2003..WNT intercellular signaling molecules have been implicated in the regulation of tooth development, and the Wnt3 gene shows specific expression in the enamel knot at the cap stage...
- Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signallingElizabeth J Robertson
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Philos Trans R Soc Lond B Biol Sci 358:1351-7; discussion 1357. 2003....
- A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryoQ Tian Wang
Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Dev Cell 6:133-44. 2004..Overall, these data provide a detailed temporal profile of gene expression that reveals the richness of signaling processes in early mammalian development...
- Expression and estradiol regulation of Wnt genes in the mouse blastocyst identify a candidate pathway for embryo-maternal signaling at implantationOthman A Mohamed
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada H3A 1A1
Biol Reprod 71:417-24. 2004....
- A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two lociDiana M Juriloff
Department of Medical Genetics, University of British Columbia, Vancouver, British ColumbiaV6T 1Z3, Canada
Birth Defects Res A Clin Mol Teratol 70:509-18. 2004..Our previous studies mapped two loci: clf1 on Chr11 and clf2 on Chr13--with a strong genetic maternal effect on the level of risk. Here we test the hypothesis that CL(P) is digenic and identify candidate genes for clf1 and clf2...
- A gene(s) for all-trans-retinoic acid-induced forelimb defects mapped and confirmed to murine chromosome 11Grace S Lee
Molecular Toxicology Interdepartmental Program, UCLA School of Public Health, Los Angeles, California 90095, USA
Genetics 170:345-53. 2005..The human syntenic region of this locus has been previously linked to Meckel syndrome; the phenotype includes postaxial polydactyly, an ectopic digital defect hypothesized to be induced by a common molecular pathway with ectrodactyly...
- Activation of canonical Wnt pathway promotes proliferation of retinal stem cells derived from adult mouse ciliary marginToshihiro Inoue
Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto City, Japan
Stem Cells 24:95-104. 2006..A combination of Wnt and FGF signaling may provide a therapeutic strategy for in vitro expansion or in vivo activation of adult retinal stem cells...
- BMP signalling inhibits premature neural differentiation in the mouse embryoAida Di-Gregorio
Molecular Embryology Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK
Development 134:3359-69. 2007..Together, our results demonstrate that inhibition of BMP signalling has a central role during neural induction in mammals and suggest that FGFs do not act as neural inducers in the post-implantation mouse embryo...
- The derivatives of the Wnt3a lineage in the central nervous systemAngeliki Louvi
Department of Neurosurgery, Program on Neurogenetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Comp Neurol 504:550-69. 2007....
- Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimbJu Suk Nam
Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
Dev Biol 311:124-35. 2007..Our findings strongly suggest that Rspo2 expression in the AER is required for AER maintenance likely by regulating Wnt/beta-catenin signaling...
- Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic developmentOlov Andersson
Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
Dev Biol 311:500-11. 2007....
- Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axisJeffery R Barrow
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Dev Biol 312:312-20. 2007..We demonstrate that embryos lacking the signaling factor Wnt3 exhibit defects in this axial realignment...
- Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryoGiovanna L Liguori
IBB Institute for Biotechnology and Bioengineering, Centro de Biomedicina Molecular e Estrutural, Universidade do Algarve, Campus de Gambelas, 8005 135 Faro, Portugal
Dev Biol 315:280-9. 2008..This signaling activity drives A-P axis positioning. Our results provide evidence for the existence of Cripto-independent signaling mechanisms, by which Nodal controls axis specification in the early mouse embryo...
- Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coliSilvia A Purro
Research Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 28:8644-54. 2008..Consistently, short hairpin RNA knockdown of APC mimics Wnt3a function. Together, our findings define APC as a key Wnt signaling target in the regulation of microtubule growth direction...
- Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesisJungmook Lyu
Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033
Dev Cell 15:773-80. 2008..is cleaved, permitting the intracellular C-terminal fragment of Ryk to translocate to the nucleus in response to Wnt3 stimulation...
- Motor neurons with axial muscle projections specified by Wnt4/5 signalingDritan Agalliu
Howard Hughes Medical Institute, Kavli Institute for Brain Science, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Neuron 61:708-20. 2009..Thus, two dorsoventral signaling pathways, mediated by Shh and Wnt4/5, are required to establish an early binary divergence in motor neuron columnar identity...
- Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle inductionYuhang Zhang
Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Dev Cell 17:49-61. 2009..These data reveal a complex interplay and interdependence of Wnt/beta-catenin and EDA/EDAR/NF-kappaB signaling pathways in initiation and maintenance of primary hair follicle placodes...
- Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cellsMarika Suomalainen
Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
Dev Dyn 239:364-72. 2010..We conclude that epithelial stem cells in the mouse incisors are not regulated directly by Wnt/beta-catenin signaling...
- Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formationJiang Fu
Department of Biomedical Genetics, Center for Oral Biology, James P Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 106:18598-603. 2009..deficient Gpr177 exhibit defects in establishment of the body axis, a phenotype highly reminiscent to the loss of Wnt3. Although many different mammalian Wnt proteins are required for a wide range of developmental processes, the Wnt3 ..
- Salmonella regulation of intestinal stem cells through the Wnt/beta-catenin pathwayXingyin Liu
Department of Medicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
FEBS Lett 584:911-6. 2010..The numbers of stem cells and proliferative cells increased in the intestine infected with Salmonella expressing AvrA. Our study provides insights into bacterial infection and stem cell maintenance...
- Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryoLeonardo Morsut
Department of Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy
Development 137:2571-8. 2010..This study unveils that intracellular negative control of Smad function by ectodermin/Tif1gamma is a crucial element in the cellular response to TGFbeta signals in mammalian tissues...
- Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tubeAlisa S W Shum
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
Dev Dyn 239:3192-203. 2010..Taken together, these results support that the lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube...
- Ectodermal Wnt/β-catenin signaling shapes the mouse faceBethany S Reid
Department of Craniofacial Biology and Cell and Developmental Biology, University of Colorado Denver, 12801 East 17th Avenue, PO Box 6511, Aurora, CO 80045, USA
Dev Biol 349:261-9. 2011....
- The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interactionYong Ri Jin
Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA
Dev Biol 352:1-13. 2011..Thus, our study identifies Rspo2 as a mesenchyme-derived factor that plays critical roles in regulating BA1 patterning and morphogenesis through ectodermal-mesenchymal interaction and a novel genetic factor for cleft palate...
- Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cellsMasato Tamura
Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University, North 13, West 7, Sapporo 060 8586, Japan
Int J Biochem Cell Biol 43:760-7. 2011..These results show that canonical Wnt signaling regulates CXCL12 gene expression at the transcriptional level, and this is the first study linking chemokine expression to canonical Wnt signaling...
- The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatusCongxing Lin
Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Dev Biol 356:40-50. 2011..We provide genetic evidence that disruption of either signaling pathway results in severe microglossia. Altogether, we demonstrate a dynamic role for Wnt-β-Catenin signaling in the development of the oral apparatus...
- The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activitiesDaniel Mesnard
Ecole Polytechnique Fédérale de Lausanne EPFL SV ISREC, CH 1015 Lausanne, Switzerland
Genes Dev 25:1871-80. 2011..Adding cell-cell communication to the pleiotropic portfolio of these proteases provides a new framework to study proprotein processing also in other relevant contexts...
- Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryoShigeto Miura
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Dev Dyn 240:2474-81. 2011..These results suggest that HGS is critical to localize TAK1 to early endosome for transducing BMP signaling for proper development. Our data revealed a new mechanism to modify BMP signaling by Hgs during early mouse development...
- Isolation and characterization of MRF-1, a brain-derived DNA-binding protein with a capacity to regulate expression of myelin basic protein geneN S Haque
Jefferson Institute of Molecular Medicine, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
J Biol Chem 269:31149-56. 1994..8, 2.5, and 3.0 kilobases which are expressed in all tissues analyzed. The gene encoding MRF-1 is located on the distal half of mouse chromosome 11 in a region where the human homolog would be predicted to reside on human chromosome 17...
- Mapping of the Prkar1a gene to mouse chromosome 11J J Moskow
Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philidelphia, Pennsylvania 19107, USA
Mamm Genome 7:464-5. 1996
- Roles of Pax-6 in murine diencephalic developmentN Warren
Department of Physiology, University Medical School, Edinburgh, UK
Development 124:1573-82. 1997..Pax-6 may also control some aspects of diencephalic differentiation, but its mutation in Small-eye mice does not preclude the development of a degree of diencephalic regionalization resembling that in normal mice...
- The WntsJ J Loureiro
Department of Biology, University of North Carolina at Chapel Hill, 27599 3280, USA
Curr Biol 9:R4. 1999
- Molecular genetic studies of Wnt signaling in the mouseM Uusitalo
Faculties of Science and Medicine, University of Oulu, Oulu, 90570, Finland
Exp Cell Res 253:336-48. 1999
- WNT signals in developing and postnatal teethSarah Millar; Fiscal Year: 2008..These experiments will help to place WNT signals in the network of regulatory factors that control tooth development, and will test the potential use of WNT activation in strategies for tooth or enamel regeneration. ..
- WNT SIGNALS IN SKIN AND HAIR DEVELOPMENT AND HAIR GROWTHSarah E Millar; Fiscal Year: 2010..abstract_text> ..
- Development of Choroid Plexus and the Blood-CSF BarrierAngeliki Louvi; Fiscal Year: 2006....
- The role of cell polarity in vertebrate limb outgrowthJeffery Barrow; Fiscal Year: 2007..Furthermore he will examine the epistatic relationship between Fgf and Wnt/PCP signaling in regulating cell polarity. [unreadable] [unreadable] [unreadable]..
- Is non-canonical Wnt signaling required in cardiac neural crest cells?Ethan David Cohen; Fiscal Year: 2008..This.information may lead to new detection or treatment strategies. [unreadable] [unreadable] [unreadable]..