F

Summary

Gene Symbol: F
Description: fusion protein
Species: Newcastle disease virus B1

Top Publications

  1. pmc Mutations in the cytoplasmic domain of the Newcastle disease virus fusion protein confer hyperfusogenic phenotypes modulating viral replication and pathogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 87:10083-93. 2013
  2. pmc Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range
    Ingrid Cornax
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, GA 30605, USA
    J Gen Virol 94:1189-94. 2013
  3. pmc Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 86:2501-11. 2012
  4. pmc Species based synonymous codon usage in fusion protein gene of Newcastle disease virus
    Chandra Shekhar Kumar
    Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati, Assam, India
    PLoS ONE 9:e114754. 2014
  5. pmc Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells
    Sayantan Bose
    Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA
    J Virol 88:3925-41. 2014
  6. pmc Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 8:e74022. 2013
  7. pmc A mutation in the stalk of the newcastle disease virus hemagglutinin-neuraminidase (HN) protein prevents triggering of the F protein despite allowing efficient HN-F complex formation
    Anne M Mirza
    Department of Microbiology and Physiological Systems, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 87:8813-5. 2013
  8. pmc The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein
    Kathryn A Gravel
    Department of Microbiology and Physiological Systems Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Virol 85:3486-97. 2011
  9. pmc Role of the two sialic acid binding sites on the newcastle disease virus HN protein in triggering the interaction with the F protein required for the promotion of fusion
    Paul J Mahon
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0002, USA
    J Virol 85:12079-82. 2011
  10. pmc Inhibition of receptor binding stabilizes Newcastle disease virus HN and F protein-containing complexes
    L W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts 01655, USA
    J Virol 80:2894-903. 2006

Scientific Experts

  • Zhuo ming Qin
  • Sweety Samal
  • Trudy G Morrison
  • Lori W McGinnes
  • Surbhi Jain
  • Peter L Collins
  • Siba K Samal
  • Anne M Mirza
  • Sayantan Bose
  • Chandra Shekhar Kumar
  • Ingrid Cornax
  • Anandan Paldurai
  • Sachin Kumar
  • Shin Hee Kim
  • Sunil K Khattar
  • Theodore S Jardetzky
  • Ronald M Iorio
  • Robert A Lamb
  • Paul J Mahon
  • Kathryn A Gravel
  • Kurt Swanson
  • Juan Ayllon
  • Ryota Tsunekuni
  • Jason P Laliberte
  • L W McGinnes
  • Albert S Song
  • Qingzhong Yu
  • Xiaoping Zhu
  • Sa Xiao
  • Senthilkumar Palaniyandi
  • Nanchaya Wanasen
  • Carlos Estevez
  • Claudio L Afonso
  • Diego G Diel
  • Patti J Miller
  • Cary A Rue
  • Julie Reitter
  • Xiaolin Wen
  • Hiroshi Kida
  • George P Leser
  • Koichi Otsuki
  • Hiroshi Ito
  • Isabel Muñoz-Barroso
  • Enrique Villar
  • Reay G Paterson
  • Toshihiro Ito
  • T G Morrison

Detail Information

Publications18

  1. pmc Mutations in the cytoplasmic domain of the Newcastle disease virus fusion protein confer hyperfusogenic phenotypes modulating viral replication and pathogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 87:10083-93. 2013
    The Newcastle disease virus (NDV) fusion protein (F) mediates fusion of viral and host cell membranes and is a major determinant of NDV pathogenicity...
  2. pmc Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range
    Ingrid Cornax
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, GA 30605, USA
    J Gen Virol 94:1189-94. 2013
    The fusion (F) and haemagglutinin-neuraminidase (HN) proteins of Newcastle disease virus (NDV) are multifunctional proteins that play critical roles during infection...
  3. pmc Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 86:2501-11. 2012
    The role of N-linked glycosylation of the Newcastle disease virus (NDV) fusion (F) protein in viral replication and pathogenesis was examined by eliminating potential acceptor sites using a reverse genetics system for the moderately ..
  4. pmc Species based synonymous codon usage in fusion protein gene of Newcastle disease virus
    Chandra Shekhar Kumar
    Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati, Assam, India
    PLoS ONE 9:e114754. 2014
    ..The NDV fusion protein (F) is a major determinant of its pathogenicity and virulence...
  5. pmc Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells
    Sayantan Bose
    Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA
    J Virol 88:3925-41. 2014
    ..Two viral integral membrane glycoproteins (fusion [F] and attachment [HN, H, or G]) mediate a concerted process of host receptor recognition, followed by the fusion of ..
  6. pmc Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 8:e74022. 2013
    ..vaccines, a full-genome reverse genetics system has been used to generate a recombinant virus in which the F protein cleavage site has been changed to that of avirulent vaccine virus...
  7. pmc A mutation in the stalk of the newcastle disease virus hemagglutinin-neuraminidase (HN) protein prevents triggering of the F protein despite allowing efficient HN-F complex formation
    Anne M Mirza
    Department of Microbiology and Physiological Systems, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 87:8813-5. 2013
    ..membrane fusion requires formation of a complex between the hemagglutinin-neuraminidase (HN) and fusion (F) proteins...
  8. pmc The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein
    Kathryn A Gravel
    Department of Microbiology and Physiological Systems Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Virol 85:3486-97. 2011
    The role of specific sequences in the transmembrane (TM) domain of Newcastle disease virus (NDV) fusion (F) protein in the structure and function of this protein was assessed by replacing this domain with the F protein TM domains from ..
  9. pmc Role of the two sialic acid binding sites on the newcastle disease virus HN protein in triggering the interaction with the F protein required for the promotion of fusion
    Paul J Mahon
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0002, USA
    J Virol 85:12079-82. 2011
    ..membrane fusion requires an interaction between the hemagglutinin-neuraminidase (HN) attachment and the fusion (F) proteins, triggered by HN's binding to receptors...
  10. pmc Inhibition of receptor binding stabilizes Newcastle disease virus HN and F protein-containing complexes
    L W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts 01655, USA
    J Virol 80:2894-903. 2006
    Receptor binding of paramyxovirus attachment proteins and the interactions between attachment and fusion (F) proteins are thought to be central to activation of the F protein activity; however, mechanisms involved are unclear...
  11. pmc Structure of the Newcastle disease virus F protein in the post-fusion conformation
    Kurt Swanson
    Howard Hughes Medical Institute, USA
    Virology 402:372-9. 2010
    The paramyxovirus F protein is a class I viral membrane fusion protein which undergoes a significant refolding transition during virus entry...
  12. doi Genetic comparisons between lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants
    Ryota Tsunekuni
    Avian Influenza Research Centre, Kyoto Sangyo University, Kamigamo Motoyama, Kyoto 603 8555, Japan
    Virus Genes 40:252-5. 2010
    ..Seven amino acid substitutions were detected in the M, F, and HN proteins...
  13. pmc Mutations in the ectodomain of newcastle disease virus fusion protein confer a hemagglutinin-neuraminidase-independent phenotype
    Juan Ayllon
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Edificio Departamental Lab 112, Plaza Doctores de la Reina s n, 37007 Salamanca, Spain
    J Virol 84:1066-75. 2010
    ..viruses into host cells is preceded by membrane fusion, which in paramyxoviruses is triggered by the fusion (F) protein...
  14. pmc Overexpression of thiol/disulfide isomerases enhances membrane fusion directed by the Newcastle disease virus fusion protein
    Surbhi Jain
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 82:12039-48. 2008
    Newcastle disease virus (NDV) fusion (F) protein directs membrane fusion, which is required for virus entry and cell-cell fusion...
  15. ncbi [Correlation of the neutralization index in chicken embryo with the homologies of F and HN gene of different Newcastle-disease isolates]
    Zhuoming Qin
    Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan 250100, China
    Wei Sheng Wu Xue Bao 48:226-33. 2008
    ..Sequence analysis based on the variable region (nucleotide 47-420) of the F gene indicated that of the 13 NDV isolates 2 belonged to genotype II, 2 to genotype IX and 9 to genotype VII...
  16. pmc Incorporation of functional HN-F glycoprotein-containing complexes into newcastle disease virus is dependent on cholesterol and membrane lipid raft integrity
    Jason P Laliberte
    Department of Molecular Genetics and Microbiology, Room S5 250, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 81:10636-48. 2007
    ..fusion capacity of particles released from cholesterol-extracted cells correlated with significant loss of HN-F glycoprotein-containing complexes detected in the virion envelopes of these particles and with detection of cell-..
  17. pmc Thiol/disulfide exchange is required for membrane fusion directed by the Newcastle disease virus fusion protein
    Surbhi Jain
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 81:2328-39. 2007
    ..sialic acid-containing receptors, followed by fusion of viral and cell membranes, which is mediated by the fusion (F) protein...
  18. ncbi [Newcastle disease virus heredity mutation and correlation of HN and F gene]
    Zhuo ming Qin
    College of Animal Science and Technology, Shandong Agriculture University, Tai an 271018, China
    Wei Sheng Wu Xue Bao 46:227-32. 2006
    ..These isolates were purified by CEF plaque assay and replicated in SPF embryos. The fusion protein (F) gene and hemagglutinin-neuraminidase (HN) gene of these isolated viruses were cloned and sequenced...