HN

Summary

Gene Symbol: HN
Description: hemagglutinin-neuraminidase
Species: Newcastle disease virus B1

Top Publications

  1. pmc A Y526Q mutation in the Newcastle disease virus HN protein reduces its functional activities and attenuates virus replication and pathogenicity
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 83:7779-82. 2009
  2. doi HN protein of Newcastle disease virus sensitizes HeLa cells to TNF-α-induced apoptosis by downregulating NF-κB expression
    R S Rajmani
    Molecular Biology Lab, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, India
    Arch Virol 161:2395-405. 2016
  3. doi HN Protein of Newcastle Disease Virus Induces Apoptosis Through SAPK/JNK Pathway
    R S Rajmani
    Molecular Biology Laboratory, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, 243122, India
    Appl Biochem Biotechnol 177:940-56. 2015
  4. doi Roles of the highly conserved amino acids in the globular head and stalk region of the Newcastle disease virus HN protein in the membrane fusion process
    Chengxi Sun
    Department of Virology, School of Public Health, Shandong University
    Biosci Trends 9:56-64. 2015
  5. pmc Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells
    Sayantan Bose
    Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA
    J Virol 88:3925-41. 2014
  6. pmc Role of C596 in the C-terminal extension of the haemagglutinin-neuraminidase protein in replication and pathogenicity of a highly virulent Indonesian strain of Newcastle disease virus
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, USA
    J Gen Virol 95:331-6. 2014
  7. pmc Measles virus fusion machinery activated by sialic acid binding globular domain
    Aparna Talekar
    Departments of Pediatrics
    J Virol 87:13619-27. 2013
  8. doi Effects of the HN gene C-terminal extensions on the Newcastle disease virus virulence
    Wei Zhao
    Southeast Poultry Research Laboratory, Agricultural Research Services, United States Department of Agriculture, 934 College Station Road, Athens, GA, 30605, USA
    Virus Genes 47:498-504. 2013
  9. doi HN gene C-terminal extension of Newcastle disease virus is not the determinant of the enteric tropism
    Wei Zhao
    College of Veterinary Medicine, Northwest A and F University, Yangling 712100, Shaanxi, China
    Virus Genes 47:27-33. 2013
  10. pmc The second receptor binding site of the globular head of the Newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion
    Matteo Porotto
    Departments of Pediatrics and of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA
    J Virol 86:5730-41. 2012

Scientific Experts

  • Zhuo ming Qin
  • R S Rajmani
  • Wei Zhao
  • Ashok K Tiwari
  • Uttara Chaturvedi
  • Qingzhong Yu
  • Aparna Talekar
  • Matteo Porotto
  • Anne M Mirza
  • Ravi Kumar Gandham
  • Shishir Kumar Gupta
  • A P Sahoo
  • Prafull Kumar Singh
  • Chengxi Sun
  • Sayantan Bose
  • Bin Lin
  • Zhiyu Wang
  • Shin Hee Kim
  • Ingrid Cornax
  • Laszlo Zsak
  • Fu Lu Chu
  • Anne Moscona
  • Ronald M Iorio
  • Siba K Samal
  • Peter L Collins
  • Min Gu
  • Paul J Mahon
  • Ryota Tsunekuni
  • Hong Sui
  • Mostafa Jarahian
  • Sunil K Khattar
  • P V Ravindra
  • Yong Wang
  • Jason P Laliberte
  • L W McGinnes
  • Ying chun Sun
  • Shikha Saxena
  • Rajiv Kumar
  • Yuzhen Chen
  • Yanyan Song
  • Fulu Chu
  • Guijie Ren
  • Hongling Wen
  • Albert S Song
  • Theodore S Jardetzky
  • Sa Xiao
  • Robert A Lamb
  • Anandan Paldurai
  • Carlos Estevez
  • Yan Zhang
  • Cary A Rue
  • Claudio L Afonso
  • Hong Ling Wen
  • Zhenyu Zhang
  • Zengqi Yang
  • Haixia Hu
  • Patti J Miller
  • Gui Jie Ren
  • Cheng Xi Sun
  • Diego G Diel
  • Yan Yan Song
  • Wen qiang Zhang
  • Ilaria Devito
  • Zuhair Salah
  • Samantha G Palmer
  • Ian A Wilson
  • Rui Xu
  • Shunlin Hu
  • Lijun Xu
  • Wujie Liu
  • Xiufan Liu
  • Chunfeng Yao
  • Yongzhong Cao
  • Yuxian Bai
  • Chun Song
  • Yongxin Zhang
  • Hiroshi Ito
  • Lejing Li
  • Toshihiro Ito
  • Fang Fu
  • Xi Li
  • Kaibing Wang
  • Koichi Otsuki
  • Hiroshi Kida
  • Adelheid Cerwenka
  • Aruna Panda
  • Yongqi Yan
  • Dominik Djandji
  • Annette Paschen
  • Philippe Fournier

Detail Information

Publications26

  1. pmc A Y526Q mutation in the Newcastle disease virus HN protein reduces its functional activities and attenuates virus replication and pathogenicity
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 83:7779-82. 2009
    The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is a multifunctional protein that plays a crucial role in virus infectivity...
  2. doi HN protein of Newcastle disease virus sensitizes HeLa cells to TNF-α-induced apoptosis by downregulating NF-κB expression
    R S Rajmani
    Molecular Biology Lab, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, India
    Arch Virol 161:2395-405. 2016
    Hemagglutinin neuraminidase (HN) is a membrane protein of Newcastle disease virus (NDV) with the ability to induce apoptosis in many transformed cell lines...
  3. doi HN Protein of Newcastle Disease Virus Induces Apoptosis Through SAPK/JNK Pathway
    R S Rajmani
    Molecular Biology Laboratory, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, 243122, India
    Appl Biochem Biotechnol 177:940-56. 2015
    ..Hemagglutinin neuraminidase (HN), a multifunctional protein of Newcastle disease virus (NDV), is one of such proteins...
  4. doi Roles of the highly conserved amino acids in the globular head and stalk region of the Newcastle disease virus HN protein in the membrane fusion process
    Chengxi Sun
    Department of Virology, School of Public Health, Shandong University
    Biosci Trends 9:56-64. 2015
    ..The hemagglutinin-neuraminidase (HN) protein of NDV has multiple functions including mediating hemadsorption (HAD), neuraminidase (NA), and fusion ..
  5. pmc Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells
    Sayantan Bose
    Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA
    J Virol 88:3925-41. 2014
    ..Two viral integral membrane glycoproteins (fusion [F] and attachment [HN, H, or G]) mediate a concerted process of host receptor recognition, followed by the fusion of viral and cellular ..
  6. pmc Role of C596 in the C-terminal extension of the haemagglutinin-neuraminidase protein in replication and pathogenicity of a highly virulent Indonesian strain of Newcastle disease virus
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, USA
    J Gen Virol 95:331-6. 2014
    We modified the haemagglutinin-neuraminidase (HN) glycoprotein of the virulent Newcastle disease virus (NDV) strain Banjarmasin/010/10 (Ban/010) by adding C-terminal extensions similar to those found in certain avirulent NDV strains...
  7. pmc Measles virus fusion machinery activated by sialic acid binding globular domain
    Aparna Talekar
    Departments of Pediatrics
    J Virol 87:13619-27. 2013
    ..to proteinaceous receptors on host cells, while the receptor binding protein of NDV (hemagglutinin-neuraminidase [HN]) interacts with sialic acid-containing receptors...
  8. doi Effects of the HN gene C-terminal extensions on the Newcastle disease virus virulence
    Wei Zhao
    Southeast Poultry Research Laboratory, Agricultural Research Services, United States Department of Agriculture, 934 College Station Road, Athens, GA, 30605, USA
    Virus Genes 47:498-504. 2013
    The hemagglutinin-neuraminidase (HN) of Newcastle disease virus (NDV) is a multifunctional protein that has receptor recognition, neuraminidase, and fusion promotion activities...
  9. doi HN gene C-terminal extension of Newcastle disease virus is not the determinant of the enteric tropism
    Wei Zhao
    College of Veterinary Medicine, Northwest A and F University, Yangling 712100, Shaanxi, China
    Virus Genes 47:27-33. 2013
    The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) plays an important role in virus pathogenicity and tissue tropism...
  10. pmc The second receptor binding site of the globular head of the Newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion
    Matteo Porotto
    Departments of Pediatrics and of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA
    J Virol 86:5730-41. 2012
    The hemagglutinin-neuraminidase (HN) protein of paramyxoviruses carries out three distinct activities contributing to the ability of HN to promote viral fusion and entry: receptor binding, receptor cleavage (neuraminidase), and activation ..
  11. pmc A mutation in the stalk of the newcastle disease virus hemagglutinin-neuraminidase (HN) protein prevents triggering of the F protein despite allowing efficient HN-F complex formation
    Anne M Mirza
    Department of Microbiology and Physiological Systems, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 87:8813-5. 2013
    ..disease virus (NDV)-induced membrane fusion requires formation of a complex between the hemagglutinin-neuraminidase (HN) and fusion (F) proteins...
  12. pmc Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range
    Ingrid Cornax
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, GA 30605, USA
    J Gen Virol 94:1189-94. 2013
    The fusion (F) and haemagglutinin-neuraminidase (HN) proteins of Newcastle disease virus (NDV) are multifunctional proteins that play critical roles during infection...
  13. doi 'a'-Position-mutated and G4-mutated hemagglutinin-neuraminidase proteins of Newcastle disease virus impair fusion and hemagglutinin-neuraminidase-fusion interaction by different mechanisms
    Fu Lu Chu
    Department of Virology, School of Public Health, Shandong University, Jinan 250012, China
    Intervirology 56:27-36. 2013
    To determine the effects of heptad repeat regions (HRs) and N-linked carbohydrate sites of the Newcastle disease virus hemagglutinin-neuraminidase (HN) protein on fusion of HN and fusion (F) proteins and HN-F interaction.
  14. ncbi [Induction of apoptosis in human hepatoma cell line SMMC7721 by Newcastle disease virus HN gene]
    Ying chun Sun
    Genetic Engineering Labotory of PLA, Academy of Military Medical Sciences, Changchun 130062, China
    Zhonghua Zhong Liu Za Zhi 27:279-82. 2005
    To investigate the mechanisms of apoptosis induced in human hepatoma cell line SMMC7721 by plasmid pVHN constructed with Newcastle disease virus (NDV) HN gene.
  15. pmc Role of the two sialic acid binding sites on the newcastle disease virus HN protein in triggering the interaction with the F protein required for the promotion of fusion
    Paul J Mahon
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0002, USA
    J Virol 85:12079-82. 2011
    ..Newcastle disease virus (NDV)-induced membrane fusion requires an interaction between the hemagglutinin-neuraminidase (HN) attachment and the fusion (F) proteins, triggered by HN's binding to receptors...
  16. pmc Positive selection in the hemagglutinin-neuraminidase gene of Newcastle disease virus and its effect on vaccine efficacy
    Min Gu
    Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, Yangzhou 225009, PR China
    Virol J 8:150. 2011
    ..the relationship between the selective pressure and the sequence variation of the hemagglutinin-neuraminidase (HN) protein, we performed the positive selection analysis by estimating the ratio of non-synonymous to synonymous ..
  17. doi The anti-tumor effect of Newcastle disease virus HN protein is influenced by differential subcellular targeting
    Hong Sui
    Medical Department, The Tumor Hospital Affiliated Harbin Medical University, Harbin, Heilongjiang, China
    Cancer Immunol Immunother 59:989-99. 2010
    ..A DNA vaccine expressing the major immunogenic hemagglutinin-neuraminidase (HN) protein of this virus has shown promising results as an immunotherapeutic agent.
  18. doi Genetic comparisons between lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants
    Ryota Tsunekuni
    Avian Influenza Research Centre, Kyoto Sangyo University, Kamigamo Motoyama, Kyoto 603 8555, Japan
    Virus Genes 40:252-5. 2010
    ..Seven amino acid substitutions were detected in the M, F, and HN proteins...
  19. pmc Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase
    Mostafa Jarahian
    German Cancer Research Center, Heidelberg, Germany
    J Virol 83:8108-21. 2009
    ..Hemagglutinin-neuraminidase (HN) of the virus serves as a ligand structure for NKp44 and NKp46, as indicated by the blockade of binding to NDV-..
  20. ncbi [Evaluation of Newcastle disease virus with derivated hemagglutinin-neuraminidase gene of mesogenic strain]
    Yong Wang
    National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China
    Wei Sheng Wu Xue Bao 48:638-43. 2008
    The hemagglutinin-neuraminidase (HN) and fusion protein of Newcastle disease virus (NDV) plays a crucial role in the process of budding and infection...
  21. ncbi [Correlation of the neutralization index in chicken embryo with the homologies of F and HN gene of different Newcastle-disease isolates]
    Zhuoming Qin
    Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan 250100, China
    Wei Sheng Wu Xue Bao 48:226-33. 2008
    ..7%-84.1%. In addition, these NDV isolates all shared 95.2%-100% nt homology with the hemagglutinin-neuraminidase (HN) gene, whereas only 79.1%-84.3% compared these viruses with La Sota...
  22. doi HN protein of Newcastle disease virus causes apoptosis in chicken embryo fibroblast cells
    P V Ravindra
    Division of Animal Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243122, India
    Arch Virol 153:749-54. 2008
    ..In the present investigation, the ability of haemagglutinin-neuraminidase (HN) protein of NDV to cause apoptosis in CEF cells was examined...
  23. pmc Incorporation of functional HN-F glycoprotein-containing complexes into newcastle disease virus is dependent on cholesterol and membrane lipid raft integrity
    Jason P Laliberte
    Department of Molecular Genetics and Microbiology, Room S5 250, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 81:10636-48. 2007
    ..reduced fusion capacity of particles released from cholesterol-extracted cells correlated with significant loss of HN-F glycoprotein-containing complexes detected in the virion envelopes of these particles and with detection of cell-..
  24. ncbi [Newcastle disease virus heredity mutation and correlation of HN and F gene]
    Zhuo ming Qin
    College of Animal Science and Technology, Shandong Agriculture University, Tai an 271018, China
    Wei Sheng Wu Xue Bao 46:227-32. 2006
    ..The fusion protein (F) gene and hemagglutinin-neuraminidase (HN) gene of these isolated viruses were cloned and sequenced...
  25. pmc Inhibition of receptor binding stabilizes Newcastle disease virus HN and F protein-containing complexes
    L W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts 01655, USA
    J Virol 80:2894-903. 2006
    ..To explore the relationships between Newcastle disease virus (NDV) HN and F protein interactions and HN protein attachment to sialic acid receptors, HN and F protein-containing complexes ..