Gene Symbol: FOXO1
Description: forkhead box O1
Alias: FOXO1A, forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, forkhead box O1A (rhabdomyosarcoma), forkhead/winged helix transcription factor FOXO1a
- Cunningham M, Zhu Q, Hammond J. FoxO1a can alter cell cycle progression by regulating the nuclear localization of p27kip in granulosa cells. Mol Endocrinol. 2004;18:1756-67 pubmed..cells, which go through an exponential growth phase during development of the ovarian follicle, we find that FoxO1a is a key regulator of the G1/S transition in these cells...
- Andreucci M, Michael A, Kramers C, Park K, Chen A, Matthaeus T, et al. Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney Int. 2003;64:1189-98 pubmed..We conclude that PI 3-kinase and Akt are activated after renal ischemia/reperfusion and that Akt phosphorylation leads to phosphorylation of FKHR and FKHRL1, which may affect epithelial cell fate in acute renal failure. ..
- Dong P, Mai Y, Zhang Z, Mi L, Wu G, Chu G, et al. MiR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1. Acta Biochim Biophys Sin (Shanghai). 2014;46:565-71 pubmed publisher..Target genes of miR-15a/b were predicted and examined, which revealed that Forkhead box protein O1 (FoxO1) is the target gene of miR-15a/b...
- Cao R, Wu W, Zhou X, Liu K, Li B, Huang X, et al. Let-7g induces granulosa cell apoptosis by targeting MAP3K1 in the porcine ovary. Int J Biochem Cell Biol. 2015;68:148-57 pubmed publisher..In further studies, we found that overexpression of let-7g induced the expression of FoxO1 in GCs and led to nuclear accumulation of dephosphorylated FoxO1...