IGFBP3

Summary

Gene Symbol: IGFBP3
Description: insulin like growth factor binding protein 3
Alias: IGFBP-3, insulin-like growth factor-binding protein 3, IBP-3, IGF-binding protein 3
Species: pig

Top Publications

  1. ncbi Follicle-stimulating hormone induction of ovarian insulin-like growth factor-binding protein-3 transcription requires a TATA box-binding protein and the protein kinase A and phosphatidylinositol-3 kinase pathways
    Elimelda Moige Ongeri
    Pennsylvania State University, College of Medicine, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Mol Endocrinol 19:1837-48. 2005
  2. pmc The TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells
    Elimelda Moige Ongeri
    Pennsylvania State University, College of Medicine, Hershey Medical Center, Hershey, PA 17033, United States
    Mol Cell Endocrinol 278:29-35. 2007
  3. doi Insulin-like growth factor-binding protein-3 mediates high glucose-induced apoptosis by increasing oxidative stress in proximal tubular epithelial cells
    Eun Gyong Yoo
    Department of Pediatrics, College of Medicine, CHA University, Sungnam 463 712, Korea
    Endocrinology 152:3135-42. 2011
  4. ncbi Structural characterization of a follicle-stimulating hormone action inhibitor in porcine ovarian follicular fluid. Its identification as the insulin-like growth factor-binding protein
    S Shimasaki
    Department of Molecular Endocrinology, Whittier Institute for Diabetes and Endocrinology, La Jolla, California 92037
    J Biol Chem 265:2198-202. 1990
  5. ncbi Identification and NH2-terminal amino acid sequence of three insulin-like growth factor-binding proteins in porcine serum
    M E Coleman
    Department of Dairy and Animal Science, Pennsylvania State University, University Park 16802
    Biochem Biophys Res Commun 181:1131-6. 1991
  6. ncbi A DraI RFLP at the porcine insulin-like growth factor binding protein 3 (IGFBP3) gene
    V H Nielsen
    Department of Breeding and Genetics, Danish Institute of Animal Science, Research Centre Foulum, Tjele, Denmark
    Anim Genet 28:152-3. 1997
  7. ncbi Effect of recombinant porcine IGF-binding protein-3 on proliferation of embryonic porcine myogenic cell cultures in the presence and absence of IGF-I
    M S Pampusch
    Animal Growth and Development Laboratory, Department of Animal Science, University of Minnesota, 348 ABLMS, 1354 Eckles Avenue, St Paul, Minnesota 55108, USA
    J Endocrinol 176:227-35. 2003
  8. ncbi Insulin-like growth factor-binding protein-3 in porcine ovarian granulosa cells: gene cloning, promoter mapping, and follicle-stimulating hormone regulation
    E Moige Ongeri
    Pennsylvania State University College of Medicine, Hershey Medical Center, 17033, USA
    Endocrinology 145:1776-85. 2004
  9. ncbi [Developmental expression changes of IGF2 and IGFBP3 genes in adipose tissue of two pig breeds]
    Yu Jiao Guo
    College of Animal Science and Technology, Sichuan Agricultural University, Ya an 625014, China
    Yi Chuan 30:602-6. 2008
  10. doi Genetic variation and association of insulin-like growth factor binding protein-3 with performance in Swine
    Wenjun Wang
    College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi, People s Republic of China
    Biochem Genet 47:315-21. 2009

Scientific Experts

  • Wenjun Wang
  • Yu Jiao Guo
  • Elimelda Moige Ongeri
  • M S Pampusch
  • Lijuan Wang
  • Eun Gyong Yoo
  • M E White
  • E Kamanga-Sollo
  • M R Hathaway
  • W R Dayton
  • Fei Lin
  • Se Eun Hyun
  • Ho Seong Kim
  • Baochun Jiang
  • Hyun Wook Chae
  • Honglin Liu
  • Guangmin Zhang
  • Duk Hee Kim
  • Jung Hyun Kim
  • Fulu Dong
  • Woo Jung Lee
  • Youngman Oh
  • V H Nielsen
  • N J Larsen
  • M E Coleman
  • S Shimasaki
  • S Inouye
  • T D Etherton
  • Y C Pan
  • N Ling
  • M Ui
  • M Shimonaka
  • F Shibata

Detail Information

Publications12

  1. ncbi Follicle-stimulating hormone induction of ovarian insulin-like growth factor-binding protein-3 transcription requires a TATA box-binding protein and the protein kinase A and phosphatidylinositol-3 kinase pathways
    Elimelda Moige Ongeri
    Pennsylvania State University, College of Medicine, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Mol Endocrinol 19:1837-48. 2005
    ..Band III was nonspecifically competed out. We conclude that FSH stimulation of IGFBP-3 transcription is mediated by cAMP via the PKA pathway and requires the P1-3 kinase and likely the MAPK pathways...
  2. pmc The TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells
    Elimelda Moige Ongeri
    Pennsylvania State University, College of Medicine, Hershey Medical Center, Hershey, PA 17033, United States
    Mol Cell Endocrinol 278:29-35. 2007
    ..This would suggest that the role of TAF4b in follicular development is regulated by FSH. TAF4b may thus be the TFIID component that binds to the TBP site on the IGFBP-3 promoter and is essential for FSH induction of IGFBP-3...
  3. doi Insulin-like growth factor-binding protein-3 mediates high glucose-induced apoptosis by increasing oxidative stress in proximal tubular epithelial cells
    Eun Gyong Yoo
    Department of Pediatrics, College of Medicine, CHA University, Sungnam 463 712, Korea
    Endocrinology 152:3135-42. 2011
    ..Increased oxidative stress from high glucose enhances IGFBP-3 expression, inducing apoptosis. Increased expression of IGFBP-3 by high glucose induces additional oxidative stress, which may result in amplification of hyperglycemic damage...
  4. ncbi Structural characterization of a follicle-stimulating hormone action inhibitor in porcine ovarian follicular fluid. Its identification as the insulin-like growth factor-binding protein
    S Shimasaki
    Department of Molecular Endocrinology, Whittier Institute for Diabetes and Endocrinology, La Jolla, California 92037
    J Biol Chem 265:2198-202. 1990
    ..A single mRNA species of 2.6 kilobases encoding the IGF-BP3 was detected in porcine gonadal, brain, and liver tissues by Northern analysis...
  5. ncbi Identification and NH2-terminal amino acid sequence of three insulin-like growth factor-binding proteins in porcine serum
    M E Coleman
    Department of Dairy and Animal Science, Pennsylvania State University, University Park 16802
    Biochem Biophys Res Commun 181:1131-6. 1991
    ..Furthermore, the presence of a truncated form(s) of the GH-dependent IGFBP-3 in porcine serum suggests that elucidating its origin and function may be important in understanding how IGFBPs affect the somatogenic actions of GH...
  6. ncbi A DraI RFLP at the porcine insulin-like growth factor binding protein 3 (IGFBP3) gene
    V H Nielsen
    Department of Breeding and Genetics, Danish Institute of Animal Science, Research Centre Foulum, Tjele, Denmark
    Anim Genet 28:152-3. 1997
  7. ncbi Effect of recombinant porcine IGF-binding protein-3 on proliferation of embryonic porcine myogenic cell cultures in the presence and absence of IGF-I
    M S Pampusch
    Animal Growth and Development Laboratory, Department of Animal Science, University of Minnesota, 348 ABLMS, 1354 Eckles Avenue, St Paul, Minnesota 55108, USA
    J Endocrinol 176:227-35. 2003
    ..These data have established that IGFBP-3 has the potential to affect proliferation of PEMCs during critical periods of muscle development that may impact ultimate muscle mass achievable postnatally...
  8. ncbi Insulin-like growth factor-binding protein-3 in porcine ovarian granulosa cells: gene cloning, promoter mapping, and follicle-stimulating hormone regulation
    E Moige Ongeri
    Pennsylvania State University College of Medicine, Hershey Medical Center, 17033, USA
    Endocrinology 145:1776-85. 2004
    ..Regulation of IGFBP-3 transcription by FSH suggests a role for IGFBP-3 in follicular development that may be independent of IGF-I...
  9. ncbi [Developmental expression changes of IGF2 and IGFBP3 genes in adipose tissue of two pig breeds]
    Yu Jiao Guo
    College of Animal Science and Technology, Sichuan Agricultural University, Ya an 625014, China
    Yi Chuan 30:602-6. 2008
    ..expression patterns of Insulin-like Growth Factor 2 (IGF2) and Insulin-like Growth Factor Binding protein 3 (IGFBP3) genes at the age of 30, 60, 90, 120 and 150 days in back subcutaneous fat tissue of Landrace and Taihu pigs, real-..
  10. doi Genetic variation and association of insulin-like growth factor binding protein-3 with performance in Swine
    Wenjun Wang
    College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi, People s Republic of China
    Biochem Genet 47:315-21. 2009
    ..The TAT/TAT pigs also scored higher in meat color than the GGC/GGC pigs. These results implied that IGFBP-3 may affect meat quality and carcass traits...
  11. doi Low-density lipoprotein-related receptor protein 1 (LRP-1) is not required for insulin-like growth factor binding protein 3 (IGFBP-3) to suppress L6 myogenic cell proliferation
    M S Pampusch
    Animal Growth and Development Laboratory, Department of Animal Science, University of Minnesota, 1354 Eckles Ave, St Paul, MN 55108, USA
    Domest Anim Endocrinol 40:197-204. 2011
    ..Our results strongly suggest that, in contrast to data obtained for nonmuscle cell lines, the LRP-1 receptor is not required for IGFBP-3 to suppress proliferation of L6 myogenic cells...
  12. doi Expression of the insulin-like growth factor system in skeletal muscle during embryonic and postnatal development in the first filial generation pigs from Erhualian and Yorkshire reciprocal crosses
    Lijuan Wang
    Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
    Gen Comp Endocrinol 173:56-62. 2011
    ..Our results may provide a valuable resource for the molecular breeding of pigs...