Apoc2

Summary

Gene Symbol: Apoc2
Description: apolipoprotein C-II
Alias: RGD1560725, apolipoprotein C2
Species: rat

Top Publications

  1. ncbi Serum apolipoproteins in heterozygous familial hypercholesterolemia
    K Kajinami
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Clin Chim Acta 211:93-9. 1992
  2. ncbi The usefulness of measuring body fat deposition for detecting obesity and atherogenesity in Japanese school children
    H Takahashi
    Department of Pediatrics, Niigata University School of Medicine, Japan
    Acta Paediatr Jpn 38:634-9. 1996
  3. ncbi Developmental and pharmacological regulation of apolipoprotein C-II gene expression. Comparison with apo C-I and apo C-III gene regulation
    Y Andersson
    U325 INSERM, Departement d Atherosclerose, Institut Pasteur de Lille et Faculté de Pharmacie, Universite de Lille II, Lille, France
    Arterioscler Thromb Vasc Biol 19:115-21. 1999
  4. ncbi Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, MGC Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 19:472-84. 1999
  5. ncbi Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis
    H Zouali
    Centre d Etude du Polymorphisme Humain, Paris, France
    Mult Scler 5:134-6. 1999
  6. ncbi Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta
    Puiying A Mak
    Department of Biological Chemistry and Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 277:31900-8. 2002
  7. ncbi Cross-linking and amyloid formation by N- and C-terminal cysteine derivatives of human apolipoprotein C-II
    Chi L L Pham
    Russell Grimwade School of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Biochemistry 41:14313-22. 2002
  8. pmc Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids
    Dimitris Kardassis
    Department of Basic Sciences, School of Health Sciences, Faculty of Medicine, University of Crete, PO Box 1393, 71500 Heraklion, Greece
    Biochem J 372:291-304. 2003
  9. ncbi [The abnormal changes of apolipoprotein(s) in patients with type 2 diabetes mellitus]
    Y Ren
    Division of Endocrinology, Department of Internal Medicine, First Affiliated Hospital, WCUMS, Chengdu 610041, China
    Hua Xi Yi Ke Da Xue Xue Bao 32:48-51, 69. 2001
  10. ncbi Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia
    C R Pullinger
    Department of Medicine, University of California, San Francisco 94143 0130
    Hum Mol Genet 2:69-74. 1993

Scientific Experts

  • D Kardassis
  • Ching Wan Lam
  • M C Jong
  • Chi L L Pham
  • Puiying A Mak
  • Y Ren
  • Y Andersson
  • H Zouali
  • Bryan A Laffitte
  • Danny M Hatters
  • Peter Tontonoz
  • Peter A Edwards
  • Linda K Curtiss
  • Sean B Joseph
  • H Takahashi
  • Catherine Desrumaux
  • Geoffrey J Howlett
  • David J Mangelsdorf
  • Lynne J Lawrence
  • B Liu
  • X Zhang
  • H Tian
  • Y Xu
  • J Yao
  • J Liang
  • B R Zysow
  • C R Pullinger
  • V Kosykh
  • Z Majd
  • B Staels
  • J C Fruchart
  • J Najib
  • G Lucotte
  • G Martin
  • L Faure-Delanef
  • A M Lefebvre
  • A V Sechkin
  • T A Hughes
  • J P Kane
  • L K Hennessy
  • M Uchiyama
  • T Kikuchi
  • J Joven
  • T Kawasaki
  • N Hashimoto
  • M Ghassemzadeh
  • K Kajinami
  • R P Winsett
  • A O Gaber
  • H S Amiri
  • S M Hughes
  • D S Elmer
  • D K Hathaway
  • X Wang
  • M Ghawji
  • R V Farese
  • E Vilella
  • M J Malloy
  • C Villabona
  • P H Frost
  • H Mabuchi
  • E Windler
  • J F Lontie
  • R Takeda
  • J Koizumi
  • R A Hegele
  • G Baggio
  • G Konemori
  • A Nakamoto
  • F Verlato
  • P W Connelly
  • J A Little
  • D L Sprecher
  • C L Malmendier
  • A J Evans
  • C Dachet
  • E Manzato
  • M W Huff
  • G Kajiyama
  • D Y Dubois
  • B M Wolfe
  • D Mathe
  • M R Baiocchi
  • J Ferezou
  • R J Havel
  • M Hiraoka
  • G B Enzi
  • M Kawanishi
  • S Martini
  • R Fellin

Detail Information

Publications21

  1. ncbi Serum apolipoproteins in heterozygous familial hypercholesterolemia
    K Kajinami
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Clin Chim Acta 211:93-9. 1992
    ..34 +/- 0.07) was significantly lower than that in normal subjects (0.39 +/- 0.05). This difference might possibly be produced by an abnormal HDL metabolism of FH patients, a topic which remains to be elucidated by further investigation...
  2. ncbi The usefulness of measuring body fat deposition for detecting obesity and atherogenesity in Japanese school children
    H Takahashi
    Department of Pediatrics, Niigata University School of Medicine, Japan
    Acta Paediatr Jpn 38:634-9. 1996
    ..low-density lipoprotein cholesterol (LDL-C), atherogenic index (AI), RLP-cholesterol (RLP-C), apoA1, apoA2, apoB, apoC2, apoC3, apoE and the ratio of apoB to apoA1 than non-overweight boys...
  3. ncbi Developmental and pharmacological regulation of apolipoprotein C-II gene expression. Comparison with apo C-I and apo C-III gene regulation
    Y Andersson
    U325 INSERM, Departement d Atherosclerose, Institut Pasteur de Lille et Faculté de Pharmacie, Universite de Lille II, Lille, France
    Arterioscler Thromb Vasc Biol 19:115-21. 1999
    ....
  4. ncbi Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, MGC Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 19:472-84. 1999
  5. ncbi Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis
    H Zouali
    Centre d Etude du Polymorphisme Humain, Paris, France
    Mult Scler 5:134-6. 1999
    ..04) with MS due to the increased frequency of the allele 6 and a decrease frequency (P < 0.03) of allele I. Our study confirms that the apolipoprotein C-II region may influence susceptibility to MS...
  6. ncbi Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta
    Puiying A Mak
    Department of Biological Chemistry and Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 277:31900-8. 2002
    ..These results suggest an alternative mechanism by which lipids are removed from macrophage foam cells...
  7. ncbi Cross-linking and amyloid formation by N- and C-terminal cysteine derivatives of human apolipoprotein C-II
    Chi L L Pham
    Russell Grimwade School of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Biochemistry 41:14313-22. 2002
    ..These data suggest that the N- and C-termini of apoC-II are close together in the amyloid fibril such that covalent cross-linking of either the N or C end of apoC-II promotes nucleation and the "seeding" of fibril growth...
  8. pmc Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids
    Dimitris Kardassis
    Department of Basic Sciences, School of Health Sciences, Faculty of Medicine, University of Crete, PO Box 1393, 71500 Heraklion, Greece
    Biochem J 372:291-304. 2003
    ....
  9. ncbi [The abnormal changes of apolipoprotein(s) in patients with type 2 diabetes mellitus]
    Y Ren
    Division of Endocrinology, Department of Internal Medicine, First Affiliated Hospital, WCUMS, Chengdu 610041, China
    Hua Xi Yi Ke Da Xue Xue Bao 32:48-51, 69. 2001
    ..To investigate the changes of the apolipoproteins(apoA I, A II, B100, C II, C III, E) in patients with type 2 diabetes mellitus...
  10. ncbi Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia
    C R Pullinger
    Department of Medicine, University of California, San Francisco 94143 0130
    Hum Mol Genet 2:69-74. 1993
    ..The presence of other factors acting together with the variant may predispose to elevated lipid levels...
  11. ncbi Pattern of hyperlipoproteinemia in human nephrotic syndrome: influence of renal failure and diabetes mellitus
    J Joven
    Centre de Recerca Biomedica, Hospital de Sant Joan de Reus, Spain
    Nephron 64:565-9. 1993
    ....
  12. ncbi Lipoprotein composition in insulin-dependent diabetes mellitus with chronic renal failure: effect of kidney and pancreas transplantation
    T A Hughes
    Department of Medicine, University of Tennessee, Memphis 38163
    Metabolism 43:333-47. 1994
    ..The addition of a pancreas to a kidney transplant had no obvious impact on the lipoproteins.(ABSTRACT TRUNCATED AT 400 WORDS)..
  13. ncbi An apolipoprotein CII mutation, CIILys19----Thr' identified in patients with hyperlipidemia
    R A Hegele
    Department of Medicine, University of Toronto, Canada
    Dis Markers 9:73-80. 1991
    ....
  14. ncbi Plasma lipids, lipoproteins and apolipoproteins in two kindreds of hypobetalipoproteinemia
    J F Lontie
    Foundation de Recherche sur l Athérosclérose, Brussels, Belgium
    Atherosclerosis 83:187-96. 1990
    ..Due to the net reduction of apolipoprotein B-containing particles (VLDL and LDL) as acceptors of lipids in HBL, there is an accumulation of large particles rich in cholesteryl esters...
  15. ncbi [Application of the box plot to evaluate serum lipid levels and apolipoprotein levels in patients with cerebral infarction and diabetes mellitus]
    G Konemori
    Department of Medicine, Futami Central Hospital, Hiroshima
    Nihon Ronen Igakkai Zasshi 27:22-7. 1990
    ..d. Compared to the control group, the ratio of LDL-C. to Apo B was lower (p less than 0.05) in the cerebral infarction group with diabetes mellitus and tended to be lower even in the diabetes mellitus-only group...
  16. pmc Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients
    G Baggio
    J Clin Invest 77:520-7. 1986
    ..A possible therapeutic role for replacement therapy of apo C-II by synthetic or recombinant apo C-II in those patients with severe hypertriglyceridemia and recurrent pancreatitis may be possible in the future...
  17. ncbi Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver
    E Windler
    J Lipid Res 26:556-65. 1985
    ..Preferential loss of apolipoprotein C-II during remnant formation may regulate the termination of triglyceride hydrolysis prior to complete removal of triglycerides from chylomicrons and VLDL...
  18. ncbi The apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred
    B R Zysow
    Department of Medicine, University of California, San Francisco 94143 0130
    Clin Genet 45:292-7. 1994
    ..The single nucleotide substitution-that causes the apoC-IILys19-->Thr variant introduces a previously unrecognized restriction site (for Mae III), that provides for easy screening...
  19. ncbi Missense mutation Leu72Pro located on the carboxyl terminal amphipathic helix of apolipoprotein C-II causes familial chylomicronemia syndrome
    Ching Wan Lam
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Clin Chim Acta 364:256-9. 2006
    ..Chylomicronemia syndrome can be caused by 2 autosomal recessive disorders - lipoprotein lipase (LPL) deficiency and apolipoprotein C-II (apo C-II) deficiency...